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Conserved domains on  [gi|71992851|ref|NP_510293|]
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START domain-containing protein [Caenorhabditis elegans]

Protein Classification

START domain-containing protein( domain architecture ID 11260985)

START (steroidogenic acute regulatory protein (StAR)-related lipid transfer) domain-containing protein may bind lipids

Gene Ontology:  GO:0008289
PubMed:  31927098|18922149

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
START smart00234
in StAR and phosphatidylcholine transfer protein; putative lipid-binding domain in StAR and ...
 33-219 7.60e-53

in StAR and phosphatidylcholine transfer protein; putative lipid-binding domain in StAR and phosphatidylcholine transfer protein


:

Pssm-ID: 214575  Cd Length: 205  Bit Score: 169.53  E-value: 7.60e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992851     33 WQLHSEKKTG----SIWSMRCnvMDNYIFRYEGRIPNrTCAEVSAMIHPQGLHRNKWDSQSAGTSLVEEISYDTsVILHK 108
Cdd:smart00234  20 WVLSSENENGdevrSIFSPGR--KPGEAFRLVGVVPM-VCADLVEELMDDLEYRPEWDKNVAKAETLEVIDNGT-VIYHY 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992851    109 TKGRMMGLISPRETLDLCRFAYDPvDGSRSVVMVSVDHEKSPRIAGVVRAQTYPTLLMLNPLGDGV-KITSIVQADLYLQ 187
Cdd:smart00234  96 VSKFAAGPVSPRDFVFVRYWREDE-DGSYAVVDVSVTHPTSPPESGYVRAENLPSGLLIEPLGNGPsKVTWVSHADLKGW 174

                          170       180       190
                   ....*....|....*....|....*....|..
gi 71992851    188 gVPQTIVDTLMPKGIASFFEDLQKYASKDCTK 219
Cdd:smart00234 175 -LPHWLVRSLIKSGLAEFAKTLVATLQKHCAK 205
 
Name Accession Description Interval E-value
START smart00234
in StAR and phosphatidylcholine transfer protein; putative lipid-binding domain in StAR and ...
 33-219 7.60e-53

in StAR and phosphatidylcholine transfer protein; putative lipid-binding domain in StAR and phosphatidylcholine transfer protein


Pssm-ID: 214575  Cd Length: 205  Bit Score: 169.53  E-value: 7.60e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992851     33 WQLHSEKKTG----SIWSMRCnvMDNYIFRYEGRIPNrTCAEVSAMIHPQGLHRNKWDSQSAGTSLVEEISYDTsVILHK 108
Cdd:smart00234  20 WVLSSENENGdevrSIFSPGR--KPGEAFRLVGVVPM-VCADLVEELMDDLEYRPEWDKNVAKAETLEVIDNGT-VIYHY 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992851    109 TKGRMMGLISPRETLDLCRFAYDPvDGSRSVVMVSVDHEKSPRIAGVVRAQTYPTLLMLNPLGDGV-KITSIVQADLYLQ 187
Cdd:smart00234  96 VSKFAAGPVSPRDFVFVRYWREDE-DGSYAVVDVSVTHPTSPPESGYVRAENLPSGLLIEPLGNGPsKVTWVSHADLKGW 174

                          170       180       190
                   ....*....|....*....|....*....|..
gi 71992851    188 gVPQTIVDTLMPKGIASFFEDLQKYASKDCTK 219
Cdd:smart00234 175 -LPHWLVRSLIKSGLAEFAKTLVATLQKHCAK 205
START cd00177
Lipid-binding START domain of mammalian STARD1-STARD15 and related proteins; This family ...
 32-212 5.37e-37

Lipid-binding START domain of mammalian STARD1-STARD15 and related proteins; This family includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, and related domains, such as the START domain of the Arabidopsis homeobox protein GLABRA 2. The mammalian STARDs are grouped into 8 subfamilies. This family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. For some members of this family, specific lipids that bind in this pocket are known; these include cholesterol (STARD1/STARD3/ STARD4/STARD5), 25-hydroxycholesterol (STARD5), phosphatidylcholine (STARD2/ STARD7/STARD10), phosphatidylethanolamine (STARD10) and ceramides (STARD11). The START domain is found either alone or in association with other domains. Mammalian STARDs participate in the control of various cellular processes including lipid trafficking between intracellular compartments, lipid metabolism, and modulation of signaling events. Mutation or altered expression of STARDs is linked to diseases such as cancer, genetic disorders, and autoimmune disease. The Arabidopsis homeobox protein GLABRA 2 suppresses root hair formation in hairless epidermal root cells.


Pssm-ID: 176851 [Multi-domain]  Cd Length: 193  Bit Score: 128.61  E-value: 5.37e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992851  32 EWQLHSEKKTGSIWSMRCNVMDNYIFRYEGRIPNrTCAEVSAMIHPQGLhRNKWDSQSAGTSLVEEISYDTSVILHKTKG 111
Cdd:cd00177  16 GWKLVKEKDGVKIYTKPYEDSGLKLLKAEGVIPA-SPEQVFELLMDIDL-RKKWDKNFEEFEVIEEIDEHTDIIYYKTKP 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992851 112 RMMglISPRETLDLCRFAYDPvDGSRSVVMVSVDHEKSPRIAGVVRAQTYPTLLMLNPLGDG-VKITSIVQADLYLQgVP 190
Cdd:cd00177  94 PWP--VSPRDFVYLRRRRKLD-DGTYVIVSKSVDHDSHPKEKGYVRAEIKLSGWIIEPLDPGkTKVTYVLQVDPKGS-IP 169

                       170       180
                ....*....|....*....|..
gi 71992851 191 QTIVDTLMPKGIASFFEDLQKY 212
Cdd:cd00177 170 KSLVNSAAKKQLASFLKDLRKA 191
START pfam01852
START domain;
78-215 1.56e-12

START domain;


Pssm-ID: 426476  Cd Length: 205  Bit Score: 64.35  E-value: 1.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992851    78 QGLHRNKWDSQSAGTSLVEEISYDTSVILHKTKGRMMGLISPRETLDLcRFAYDPVDGSRSVVMVSVDHEKSPRIAGVVR 157
Cdd:pfam01852  65 DMEYRAQWDKDVRSAETLEVISSGGDLQYYVAALVAPSPLSPRDFVFL-RYWRRLGGGVYVIVDRSVTHPQFPPSSGYVR 143

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71992851   158 AQTYPTLLMLNPLGDGV-KITSIVQADLYLQGVPQTI---VDTLMPKGIASFFEDLQKYASK 215
Cdd:pfam01852 144 AERLPSGYLIQPCGNGPsKVTWVSHADLKGWLPSWLLrslYKSGMPEGAKTWVATLQRLCEK 205
PLN00188 PLN00188
enhanced disease resistance protein (EDR2); Provisional
 67-158 3.73e-04

enhanced disease resistance protein (EDR2); Provisional


Pssm-ID: 215094 [Multi-domain]  Cd Length: 719  Bit Score: 41.33  E-value: 3.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992851   67 TCAEVSAMIHPQGLHRNKWDSQSAGTSLVEEISYDTSVILHKTK-GRMMGLISPRetlDLCRFAY----DpvDGSRSVVM 141
Cdd:PLN00188 238 TCEEIFELVMSMDGTRFEWDCSFQYGSLVEEVDGHTAILYHRLQlDWFPMFVWPR---DLCYVRYwrrnD--DGSYVVLF 312

                         90
                 ....*....|....*..
gi 71992851  142 VSVDHEKSPRIAGVVRA 158
Cdd:PLN00188 313 RSREHENCGPQPGFVRA 329
 
Name Accession Description Interval E-value
START smart00234
in StAR and phosphatidylcholine transfer protein; putative lipid-binding domain in StAR and ...
 33-219 7.60e-53

in StAR and phosphatidylcholine transfer protein; putative lipid-binding domain in StAR and phosphatidylcholine transfer protein


Pssm-ID: 214575  Cd Length: 205  Bit Score: 169.53  E-value: 7.60e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992851     33 WQLHSEKKTG----SIWSMRCnvMDNYIFRYEGRIPNrTCAEVSAMIHPQGLHRNKWDSQSAGTSLVEEISYDTsVILHK 108
Cdd:smart00234  20 WVLSSENENGdevrSIFSPGR--KPGEAFRLVGVVPM-VCADLVEELMDDLEYRPEWDKNVAKAETLEVIDNGT-VIYHY 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992851    109 TKGRMMGLISPRETLDLCRFAYDPvDGSRSVVMVSVDHEKSPRIAGVVRAQTYPTLLMLNPLGDGV-KITSIVQADLYLQ 187
Cdd:smart00234  96 VSKFAAGPVSPRDFVFVRYWREDE-DGSYAVVDVSVTHPTSPPESGYVRAENLPSGLLIEPLGNGPsKVTWVSHADLKGW 174

                          170       180       190
                   ....*....|....*....|....*....|..
gi 71992851    188 gVPQTIVDTLMPKGIASFFEDLQKYASKDCTK 219
Cdd:smart00234 175 -LPHWLVRSLIKSGLAEFAKTLVATLQKHCAK 205
START cd00177
Lipid-binding START domain of mammalian STARD1-STARD15 and related proteins; This family ...
 32-212 5.37e-37

Lipid-binding START domain of mammalian STARD1-STARD15 and related proteins; This family includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, and related domains, such as the START domain of the Arabidopsis homeobox protein GLABRA 2. The mammalian STARDs are grouped into 8 subfamilies. This family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. For some members of this family, specific lipids that bind in this pocket are known; these include cholesterol (STARD1/STARD3/ STARD4/STARD5), 25-hydroxycholesterol (STARD5), phosphatidylcholine (STARD2/ STARD7/STARD10), phosphatidylethanolamine (STARD10) and ceramides (STARD11). The START domain is found either alone or in association with other domains. Mammalian STARDs participate in the control of various cellular processes including lipid trafficking between intracellular compartments, lipid metabolism, and modulation of signaling events. Mutation or altered expression of STARDs is linked to diseases such as cancer, genetic disorders, and autoimmune disease. The Arabidopsis homeobox protein GLABRA 2 suppresses root hair formation in hairless epidermal root cells.


Pssm-ID: 176851 [Multi-domain]  Cd Length: 193  Bit Score: 128.61  E-value: 5.37e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992851  32 EWQLHSEKKTGSIWSMRCNVMDNYIFRYEGRIPNrTCAEVSAMIHPQGLhRNKWDSQSAGTSLVEEISYDTSVILHKTKG 111
Cdd:cd00177  16 GWKLVKEKDGVKIYTKPYEDSGLKLLKAEGVIPA-SPEQVFELLMDIDL-RKKWDKNFEEFEVIEEIDEHTDIIYYKTKP 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992851 112 RMMglISPRETLDLCRFAYDPvDGSRSVVMVSVDHEKSPRIAGVVRAQTYPTLLMLNPLGDG-VKITSIVQADLYLQgVP 190
Cdd:cd00177  94 PWP--VSPRDFVYLRRRRKLD-DGTYVIVSKSVDHDSHPKEKGYVRAEIKLSGWIIEPLDPGkTKVTYVLQVDPKGS-IP 169

                       170       180
                ....*....|....*....|..
gi 71992851 191 QTIVDTLMPKGIASFFEDLQKY 212
Cdd:cd00177 170 KSLVNSAAKKQLASFLKDLRKA 191
START_STARD4_5_6-like cd08867
Lipid-binding START domain of mammalian STARD4, -5, -6, and related proteins; This subfamily ...
 32-211 1.02e-23

Lipid-binding START domain of mammalian STARD4, -5, -6, and related proteins; This subfamily includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD4, -5, and -6. The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. STARD4 plays an important role in steroidogenesis, trafficking cholesterol into mitochondria. It specifically binds cholesterol, and demonstrates limited binding to another sterol, 7a-hydroxycholesterol. STARD4 and STARD5 are ubiquitously expressed, with highest levels in liver and kidney. STRAD5 functions in the kidney within the proximal tubule cells where it is associated with the Endoplasmic Reticulum (ER), and may participate in ER-associated cholesterol transport. It binds cholesterol and 25-hydroxycholesterol. Expression of the gene encoding STARD5 is increased by ER stress, and its mRNA and protein levels are elevated in a type I diabetic mouse model of human diabetic nephropathy. STARD6 is expressed in male germ cells of normal rats, and in the steroidogenic Leydig cells of perinatal hypothyroid testes. It may play a pivotal role in the steroidogenesis as well as in the spermatogenesis of normal rats. STARD6 has also been detected in the rat nervous system, and may participate in neurosteroid synthesis.


Pssm-ID: 176876  Cd Length: 206  Bit Score: 94.45  E-value: 1.02e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992851  32 EWQLHSEKKTGSIWSMRCNVMDNYIFRYEGRIPNrTCAEVSAMIHPQ-GLHRNKWDSQSAGTSLVEEISYDTSVILHKTK 110
Cdd:cd08867  23 GWKVLKTVKNITVSWKPSTEFTGHLYRAEGIVDA-LPEKVIDVIIPPcGGLRLKWDKSLKHYEVLEKISEDLCVGRTITP 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992851 111 GRMMGLISPRETLDL-CRFAYDpvDGSRSVVMVSVDHEKSPRIAGVVRAQTYPTLLMLNPLGDG---VKITSIVQADlyL 186
Cdd:cd08867 102 SAAMGLISPRDFVDLvYVKRYE--DNQWSSSGKSVDIPERPPTPGFVRGYNHPCGYFCSPLKGSpdkSFLVLYVQTD--L 177

                       170       180
                ....*....|....*....|....*.
gi 71992851 187 QG-VPQTIVDTLMPKGIASFFEDLQK 211
Cdd:cd08867 178 RGmIPQSLVESAMPSNLVNFYTDLVK 203
START_STARD5-like cd08903
Lipid-binding START domain of mammalian STARD5 and related proteins; This subgroup includes ...
 56-211 6.25e-17

Lipid-binding START domain of mammalian STARD5 and related proteins; This subgroup includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD5, and related domains. It belongs to the START domain family, and in turn to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. STARD5 is ubiquitously expressed, with highest levels in liver and kidney. STARD5 functions in the kidney within the proximal tubule cells where it is associated with the Endoplasmic Reticulum (ER), and may participate in ER-associated cholesterol transport. It binds cholesterol and 25-hydroxycholesterol. Expression of the gene encoding STARD5 is increased by ER stress, and its mRNA and protein levels are elevated in a type I diabetic mouse model of human diabetic nephropathy.


Pssm-ID: 176912  Cd Length: 208  Bit Score: 76.41  E-value: 6.25e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992851  56 IFRYEGRIPNrTCAEVSAMIHPQ--GLhRNKWDSQSAGTSLVEEISYDTSVILHKTKGRMMGLISPRETLDLCRFA-YDp 132
Cdd:cd08903  47 LYKGEGIVYA-TLEQVWDCLKPAagGL-RVKWDQNVKDFEVVEAISDDVSVCRTVTPSAAMKIISPRDFVDVVLVKrYE- 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992851 133 vDGSRSVVMVSVDHEKSPRIAGVVRAQTYPTLLMLNPL-GDGVK--ITSIVQADL--YLqgvPQTIVDTLMPKGIASFFE 207
Cdd:cd08903 124 -DGTISSNATNVEHPLCPPQAGFVRGFNHPCGCFCEPVpGEPDKtqLVSFFQTDLsgYL---PQTVVDSFFPASMAEFYN 199


                ....
gi 71992851 208 DLQK 211
Cdd:cd08903 200 NLTK 203
START_STARD4-like cd08902
Lipid-binding START domain of mammalian STARD4 and related proteins; This subgroup includes ...
 25-211 2.03e-13

Lipid-binding START domain of mammalian STARD4 and related proteins; This subgroup includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD4 and related domains. It belongs to the START domain family, and in turn to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. STARD4 plays an important role in steroidogenesis, trafficking cholesterol into mitochondria. It specifically binds cholesterol, and demonstrates limited binding to another sterol, 7alpha-hydroxycholesterol. STARD4 is ubiquitously expressed, with highest levels in liver and kidney.


Pssm-ID: 176911  Cd Length: 202  Bit Score: 66.52  E-value: 2.03e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992851  25 FHLLHSLEWQLHSEKKTGSIWSMRCNVMDNYIFRYEGRIPNRTcAEVSAMIHPqGLHRNKWDSQSAGTSLVEEISYDTSV 104
Cdd:cd08902  17 YHSILEEEWRVAKKSKDVTVWRKPSEEFGGYLYKAQGVVEDVY-NRIVDHIRP-GPYRLDWDSLMTSMDIIEEFEENCCV 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992851 105 ILHKTKGRMMGLISPRETLDlcrFAYDPV--DGSRSvVMVSVDHEKS-PRIagvVRAQTYPTLLMLNPLGDGVK---ITS 178
Cdd:cd08902  95 MRYTTAGQLLNIISPREFVD---FSYTTQyeDGLLS-CGVSIEYEEArPNF---VRGFNHPCGWFCVPLKDNPShslLTG 167

                       170       180       190
                ....*....|....*....|....*....|....
gi 71992851 179 IVQADlyLQG-VPQTIVDTLMPKGIASFFEDLQK 211
Cdd:cd08902 168 YIQTD--LRGmLPQSAVDTAMASTLVNFYSDLKK 199
START pfam01852
START domain;
78-215 1.56e-12

START domain;


Pssm-ID: 426476  Cd Length: 205  Bit Score: 64.35  E-value: 1.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992851    78 QGLHRNKWDSQSAGTSLVEEISYDTSVILHKTKGRMMGLISPRETLDLcRFAYDPVDGSRSVVMVSVDHEKSPRIAGVVR 157
Cdd:pfam01852  65 DMEYRAQWDKDVRSAETLEVISSGGDLQYYVAALVAPSPLSPRDFVFL-RYWRRLGGGVYVIVDRSVTHPQFPPSSGYVR 143

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71992851   158 AQTYPTLLMLNPLGDGV-KITSIVQADLYLQGVPQTI---VDTLMPKGIASFFEDLQKYASK 215
Cdd:pfam01852 144 AERLPSGYLIQPCGNGPsKVTWVSHADLKGWLPSWLLrslYKSGMPEGAKTWVATLQRLCEK 205
START_STARD6-like cd08904
Lipid-binding START domain of mammalian STARD6 and related proteins; This subgroup includes ...
 33-210 3.52e-11

Lipid-binding START domain of mammalian STARD6 and related proteins; This subgroup includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD6 and related domains. It belongs to the START domain family, and in turn to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. STARD6 is expressed in male germ cells of normal rats, and in the steroidogenic Leydig cells of perinatal hypothyroid testes. It may play a pivotal role in the steroidogenesis as well as in the spermatogenesis of normal rats. STARD6 has also been detected in the rat nervous system, and may participate in neurosteroid synthesis.


Pssm-ID: 176913  Cd Length: 204  Bit Score: 60.69  E-value: 3.52e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992851  33 WQLHSEKKTGSIWSMRCNVMDNYIFRYEGRIPNRTCAEVSAMIHPQglHRNKWDSQSAGTSLVEEISYDTSVILHKTKGR 112
Cdd:cd08904  24 WKVVKTSKKITVSWKPSRKYHGNLYRVEGIIPESPAKLIQFMYQPE--HRIKWDKSLQVYKMLQRIDSDTFICHTITQSF 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992851 113 MMGLISPRETLDLCRFAYdpVDGSRSVV-MVSVDHEKSPRIAGVVRAQTYPTLLMLNPLGDG---VKITSIVQADLYlQG 188
Cdd:cd08904 102 AMGSISPRDFVDLVHIKR--YEGNMNIVsSVSVEYPQCPPSSNYIRGYNHPCGYVCSPLPENpaySKLVMFVQPELR-GN 178

                       170       180
                ....*....|....*....|..
gi 71992851 189 VPQTIVDTLMPKGIASFFEDLQ 210
Cdd:cd08904 179 LSRSVIEKTMPTNLVNLILDAK 200
START_STARD1_3_like cd08868
Cholesterol-binding START domain of mammalian STARD1, -3 and related proteins; This subfamily ...
 19-214 1.36e-05

Cholesterol-binding START domain of mammalian STARD1, -3 and related proteins; This subfamily includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD1 (also known as StAR) and STARD3 (also known as metastatic lymph node 64/MLN64). The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. This STARD1-like subfamily has a high affinity for cholesterol. STARD1/StAR can reduce macrophage lipid content and inflammatory status. It plays an essential role in steroidogenic tissues: transferring the steroid precursor, cholesterol, from the outer to the inner mitochondrial membrane, across the aqueous space. Mutations in the gene encoding STARD1/StAR can cause lipid congenital adrenal hyperplasia (CAH), an autosomal recessive disorder characterized by a steroid synthesis deficiency and an accumulation of cholesterol in the adrenal glands and the gonads. STARD3 may function in trafficking endosomal cholesterol to a cytosolic acceptor or membrane. In addition to having a cytoplasmic START cholesterol-binding domain, STARD3 also contains an N-terminal MENTAL cholesterol-binding and protein-protein interaction domain. The MENTAL domain contains transmembrane helices and anchors MLN64 to endosome membranes. The gene encoding STARD3 is overexpressed in about 25% of breast cancers.


Pssm-ID: 176877  Cd Length: 208  Bit Score: 44.65  E-value: 1.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992851  19 NAENRVFHLLHSLEWQLHSEKKTG-SIWSMrcNVMD-NYIFRYEGRI---PNRTCAEVSAMIHPQGLhrnkWDSQSAGTS 93
Cdd:cd08868  12 EALARAWSILTDPGWKLEKNTTWGdVVYSR--NVPGvGKVFRLTGVLdcpAEFLYNELVLNVESLPS----WNPTVLECK 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992851  94 LVEEISYDTSVILHKTKGRMMGLISPRETLDLCRFAYDpvdGSRSVVM-VSVDHEKSPRIAGVVRAQTYPTLLMLNPLG- 171
Cdd:cd08868  86 IIQVIDDNTDISYQVAAEAGGGLVSPRDFVSLRHWGIR---ENCYLSSgVSVEHPAMPPTKNYVRGENGPGCWILRPLPn 162

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 71992851 172 --DGVKITSIVQADLYLqGVPQTIVDTLMPKGIASFFEDLQKYAS 214
Cdd:cd08868 163 npNKCNFTWLLNTDLKG-WLPQYLVDQALASVLLDFMKHLRKRIA 206
PLN00188 PLN00188
enhanced disease resistance protein (EDR2); Provisional
 67-158 3.73e-04

enhanced disease resistance protein (EDR2); Provisional


Pssm-ID: 215094 [Multi-domain]  Cd Length: 719  Bit Score: 41.33  E-value: 3.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992851   67 TCAEVSAMIHPQGLHRNKWDSQSAGTSLVEEISYDTSVILHKTK-GRMMGLISPRetlDLCRFAY----DpvDGSRSVVM 141
Cdd:PLN00188 238 TCEEIFELVMSMDGTRFEWDCSFQYGSLVEEVDGHTAILYHRLQlDWFPMFVWPR---DLCYVRYwrrnD--DGSYVVLF 312

                         90
                 ....*....|....*..
gi 71992851  142 VSVDHEKSPRIAGVVRA 158
Cdd:PLN00188 313 RSREHENCGPQPGFVRA 329
START_STARD1-like cd08905
Cholesterol-binding START domain of mammalian STARD1 and related proteins; This subgroup ...
 81-211 1.27e-03

Cholesterol-binding START domain of mammalian STARD1 and related proteins; This subgroup includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD1 (also known as StAR) and related proteins. It belongs to the START domain family, and in turn to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. STARD1 has a high affinity for cholesterol. It can reduce macrophage lipid content and inflammatory status. It plays an essential role in steroidogenic tissues: transferring the steroid precursor, cholesterol, from the outer to the inner mitochondrial membrane, across the aqueous space. Mutations in the gene encoding STARD1/StAR can cause lipid congenital adrenal hyperplasia (CAH), an autosomal recessive disorder characterized by a steroid synthesis deficiency and an accumulation of cholesterol in the adrenal glands and the gonads.


Pssm-ID: 176914  Cd Length: 209  Bit Score: 38.66  E-value: 1.27e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992851  81 HRNKWDSQSAGTSLVEEISYDTsVILHKTKGRMMG-LISPRetlDLCRFAYDPVDGSRSVVM-VSVDHEKSPRIAGVVRA 158
Cdd:cd08905  74 QMGEWNPNVKEVKILQRIGKDT-LITHEVAAETAGnVVGPR---DFVSVRCAKRRGSTCVLAgMATHFGLMPEQKGFIRA 149

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 71992851 159 QTYPTLLMLNPLGDGV---KITSIVQADlyLQG-VPQTIVDTLMPKGIASFFEDLQK 211
Cdd:cd08905 150 ENGPTCIVLRPLAGDPsktKLTWLLSID--LKGwLPKSIINQVLSQTQVDFANHLRQ 204
START_RhoGAP cd08869
C-terminal lipid-binding START domain of mammalian STARD8, -12, -13 and related proteins, ...
 82-184 9.68e-03

C-terminal lipid-binding START domain of mammalian STARD8, -12, -13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain; This subfamily includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD8 (also known as deleted in liver cancer 3/DLC3, and Arhgap38), STARD12 (also known as DLC-1, Arhgap7, and p122-RhoGAP), and STARD13 (also known as DLC-2, Arhgap37, and SDCCAG13). The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. Proteins belonging to this subfamily also have a RhoGAP domain. Some, including STARD12, -and -13, also have an N-terminal SAM (sterile alpha motif) domain; these have a SAM-RhoGAP-START domain organization. This subfamily is involved in cancer development. A large spectrum of cancers have dysregulated genes encoding these proteins. The precise function of the START domain in this subfamily is unclear.


Pssm-ID: 176878  Cd Length: 197  Bit Score: 36.13  E-value: 9.68e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992851  82 RNKWDSQSAGTSLVEEISYDTSVILHKTKGrmmglISPRETLDLC--RF-AYDPVDGSRSVVMVSVDHEKSPRIAGvVRA 158
Cdd:cd08869  67 RHLWDDDLLQWKVVETLDEDTEVYQYVTNS-----MAPHPTRDYVvlRTwRTDLPKGACVLVETSVEHTEPVPLGG-VRA 140

                        90       100
                ....*....|....*....|....*..
gi 71992851 159 QTYPTLLMLNPLGDG-VKITSIVQADL 184
Cdd:cd08869 141 VVLASRYLIEPCGSGkSRVTHICRVDL 167
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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