NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17550672|ref|NP_510461|]
View 

Dipeptidyl peptidase family member 2 [Caenorhabditis elegans]

Protein Classification

S9 family peptidase( domain architecture ID 12012113)

S9 family peptidase, an oligopeptidase which may cleave the prolyl bond of short peptides, similar to Aspergillus oryzae dipeptidyl peptidase 4 which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline

CATH:  3.40.50.1820|2.140.10.30
EC:  3.4.-.-
Gene Ontology:  GO:0008236|GO:0006508
MEROPS:  S9
PubMed:  19508187|12369917|35631755
SCOP:  3000102

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 152-536 2.59e-95

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


:

Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 301.93  E-value: 2.59e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672   152 SSNMKYAYGSKKVNELWRHSAEYLYHIVKINNKTVsteqWHVGPEEnSLIQAFYWNPNasSNDFVYVHNYNLYYQKDPEK 231
Cdd:pfam00930   1 SPDGKYLLLATNYTKNWRHSYTADYYIYDLETNRV----EPLPPGE-GKIQDAKWSPD--GDRLAFVRDNNLYVRELATG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672   232 PdgAIQLTVGGSTFNRFGLANWLYEEEILEASSAVWWSPSGRYVSYLRFDDREVNRIFLPKYTDDDSYVEYFELPYPKAG 311
Cdd:pfam00930  74 K--EIQITSDGSDGIFNGVADWVYEEEVLGSNSAVWWSPDGSRLAFLRFDESEVPIITLPYYTDEGPGPEVREIKYPKAG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672   312 vQNNTLVTQYIWDSENHKIVETAPPNELSaaNGDYYVLTNKWitmprngsdLGEERLVTVWANRDQNHVYFSLC----NE 387
Cdd:pfam00930 152 -APNPTVELFVYDLASGKTVEVVPPDDLS--DADYYITRVKW---------VPDGKLLVQWLNRDQNRLKVVLCdaetGR 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672   388 QDCVMalsfqfsIDNRQLWVSPKDVRGVF-PTETGFLTVLPHkhdDGniYNHVAHVELDGTGTGKITKwigENFDVILVL 466
Cdd:pfam00930 220 TVVIL-------EETSDGWVELHQDPHFIkRDGSGFLWISER---DG--YNHLYLYDLDGKSPIQLTS---GNWEVTSIL 284

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672   467 GYSSKIDALTFSAYGDGVGEFSTYIVREamysNKKTTLQKVTDQFEDCKtlGSQSADPTGQRIVVQCEKP 536
Cdd:pfam00930 285 GVDETRDLVYFTATEDSPTERHLYSVSL----DSGGEPTCLTDDSGDHD--YSASFSPNGSYYVLTYSGP 348
Peptidase_S9 super family cl47529
Prolyl oligopeptidase family;
625-801 4.62e-45

Prolyl oligopeptidase family;


The actual alignment was detected with superfamily member pfam00326:

Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 161.24  E-value: 4.62e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672   625 IQIVSQYDIAYARIDVRGTGGRGWDVKEAVYRKLGDAEVVDTLDMIRAFINTfGFIDEDRIAVMGWSYGGFLTSKIAiKD 704
Cdd:pfam00326   7 AQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQ-GYTDPDRLAIWGGSYGGYLTGAAL-NQ 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672   705 QGELVKCAISIAPVTDFKYYDS----AYTERYL--GQPAENLQGYINTNVIPHARNVT-NVKYLLAHGERDDNVHYQNSA 777
Cdd:pfam00326  85 RPDLFKAAVAHVPVVDWLAYMSdtslPFTERYMewGNPWDNEEGYDYLSPYSPADNVKvYPPLLLIHGLLDDRVPPWQSL 164

                         170       180
                  ....*....|....*....|....
gi 17550672   778 RWSEALQQNGIHFTQLVYANEAHS 801
Cdd:pfam00326 165 KLVAALQRKGVPFLLLIFPDEGHG 188
 
Name Accession Description Interval E-value
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 152-536 2.59e-95

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 301.93  E-value: 2.59e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672   152 SSNMKYAYGSKKVNELWRHSAEYLYHIVKINNKTVsteqWHVGPEEnSLIQAFYWNPNasSNDFVYVHNYNLYYQKDPEK 231
Cdd:pfam00930   1 SPDGKYLLLATNYTKNWRHSYTADYYIYDLETNRV----EPLPPGE-GKIQDAKWSPD--GDRLAFVRDNNLYVRELATG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672   232 PdgAIQLTVGGSTFNRFGLANWLYEEEILEASSAVWWSPSGRYVSYLRFDDREVNRIFLPKYTDDDSYVEYFELPYPKAG 311
Cdd:pfam00930  74 K--EIQITSDGSDGIFNGVADWVYEEEVLGSNSAVWWSPDGSRLAFLRFDESEVPIITLPYYTDEGPGPEVREIKYPKAG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672   312 vQNNTLVTQYIWDSENHKIVETAPPNELSaaNGDYYVLTNKWitmprngsdLGEERLVTVWANRDQNHVYFSLC----NE 387
Cdd:pfam00930 152 -APNPTVELFVYDLASGKTVEVVPPDDLS--DADYYITRVKW---------VPDGKLLVQWLNRDQNRLKVVLCdaetGR 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672   388 QDCVMalsfqfsIDNRQLWVSPKDVRGVF-PTETGFLTVLPHkhdDGniYNHVAHVELDGTGTGKITKwigENFDVILVL 466
Cdd:pfam00930 220 TVVIL-------EETSDGWVELHQDPHFIkRDGSGFLWISER---DG--YNHLYLYDLDGKSPIQLTS---GNWEVTSIL 284

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672   467 GYSSKIDALTFSAYGDGVGEFSTYIVREamysNKKTTLQKVTDQFEDCKtlGSQSADPTGQRIVVQCEKP 536
Cdd:pfam00930 285 GVDETRDLVYFTATEDSPTERHLYSVSL----DSGGEPTCLTDDSGDHD--YSASFSPNGSYYVLTYSGP 348
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
625-801 4.62e-45

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 161.24  E-value: 4.62e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672   625 IQIVSQYDIAYARIDVRGTGGRGWDVKEAVYRKLGDAEVVDTLDMIRAFINTfGFIDEDRIAVMGWSYGGFLTSKIAiKD 704
Cdd:pfam00326   7 AQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQ-GYTDPDRLAIWGGSYGGYLTGAAL-NQ 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672   705 QGELVKCAISIAPVTDFKYYDS----AYTERYL--GQPAENLQGYINTNVIPHARNVT-NVKYLLAHGERDDNVHYQNSA 777
Cdd:pfam00326  85 RPDLFKAAVAHVPVVDWLAYMSdtslPFTERYMewGNPWDNEEGYDYLSPYSPADNVKvYPPLLLIHGLLDDRVPPWQSL 164

                         170       180
                  ....*....|....*....|....
gi 17550672   778 RWSEALQQNGIHFTQLVYANEAHS 801
Cdd:pfam00326 165 KLVAALQRKGVPFLLLIFPDEGHG 188
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
576-817 1.30e-41

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 152.09  E-value: 1.30e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672 576 LKLPSGIDGHYMMLTPAnllDGAKIPLLLDIYGGPDSKQVFqktpTAHAIQIVSQYDIAYARIDVRGTGGRGwdvkeavy 655
Cdd:COG1506   2 FKSADGTTLPGWLYLPA---DGKKYPVVVYVHGGPGSRDDS----FLPLAQALASRGYAVLAPDYRGYGESA-------- 66

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672 656 RKLGDAEVVDTLDMIRAFINTfGFIDEDRIAVMGWSYGGFLTSKIAIKDQgELVKCAISIAPVTDFKYYD---SAYTERY 732
Cdd:COG1506  67 GDWGGDEVDDVLAAIDYLAAR-PYVDPDRIGIYGHSYGGYMALLAAARHP-DRFKAAVALAGVSDLRSYYgttREYTERL 144

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672 733 LGQPAENLQGYINTNVIPHARNVTnVKYLLAHGERDDNVHYQNSARWSEALQQNGIHFTQLVYANEAHSLSHKLF-HLYG 811
Cdd:COG1506 145 MGGPWEDPEAYAARSPLAYADKLK-TPLLLIHGEADDRVPPEQAERLYEALKKAGKPVELLVYPGEGHGFSGAGApDYLE 223


                ....*.
gi 17550672 812 EVQRFL 817
Cdd:COG1506 224 RILDFL 229
PRK05371 PRK05371
x-prolyl-dipeptidyl aminopeptidase; Provisional
 751-820 1.87e-03

x-prolyl-dipeptidyl aminopeptidase; Provisional


Pssm-ID: 235435 [Multi-domain]  Cd Length: 767  Bit Score: 41.91  E-value: 1.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672  751 HARN----VTNVK--YLLAHGERDDNVHYQNSARWSEALQQNGI------HFTQLVYANEAHS----------LSHKLFH 808
Cdd:PRK05371 443 DDRNylkdADKIKasVLVVHGLNDWNVKPKQVYQWWDALPENGVpkklflHQGGHVYPNNWQSidfrdtmnawFTHKLLG 522

                         90
                 ....*....|..
gi 17550672  809 LYGEVQRFLMND 820
Cdd:PRK05371 523 IDNGVENELPAV 534
 
Name Accession Description Interval E-value
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 152-536 2.59e-95

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 301.93  E-value: 2.59e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672   152 SSNMKYAYGSKKVNELWRHSAEYLYHIVKINNKTVsteqWHVGPEEnSLIQAFYWNPNasSNDFVYVHNYNLYYQKDPEK 231
Cdd:pfam00930   1 SPDGKYLLLATNYTKNWRHSYTADYYIYDLETNRV----EPLPPGE-GKIQDAKWSPD--GDRLAFVRDNNLYVRELATG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672   232 PdgAIQLTVGGSTFNRFGLANWLYEEEILEASSAVWWSPSGRYVSYLRFDDREVNRIFLPKYTDDDSYVEYFELPYPKAG 311
Cdd:pfam00930  74 K--EIQITSDGSDGIFNGVADWVYEEEVLGSNSAVWWSPDGSRLAFLRFDESEVPIITLPYYTDEGPGPEVREIKYPKAG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672   312 vQNNTLVTQYIWDSENHKIVETAPPNELSaaNGDYYVLTNKWitmprngsdLGEERLVTVWANRDQNHVYFSLC----NE 387
Cdd:pfam00930 152 -APNPTVELFVYDLASGKTVEVVPPDDLS--DADYYITRVKW---------VPDGKLLVQWLNRDQNRLKVVLCdaetGR 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672   388 QDCVMalsfqfsIDNRQLWVSPKDVRGVF-PTETGFLTVLPHkhdDGniYNHVAHVELDGTGTGKITKwigENFDVILVL 466
Cdd:pfam00930 220 TVVIL-------EETSDGWVELHQDPHFIkRDGSGFLWISER---DG--YNHLYLYDLDGKSPIQLTS---GNWEVTSIL 284

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672   467 GYSSKIDALTFSAYGDGVGEFSTYIVREamysNKKTTLQKVTDQFEDCKtlGSQSADPTGQRIVVQCEKP 536
Cdd:pfam00930 285 GVDETRDLVYFTATEDSPTERHLYSVSL----DSGGEPTCLTDDSGDHD--YSASFSPNGSYYVLTYSGP 348
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
625-801 4.62e-45

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 161.24  E-value: 4.62e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672   625 IQIVSQYDIAYARIDVRGTGGRGWDVKEAVYRKLGDAEVVDTLDMIRAFINTfGFIDEDRIAVMGWSYGGFLTSKIAiKD 704
Cdd:pfam00326   7 AQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQ-GYTDPDRLAIWGGSYGGYLTGAAL-NQ 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672   705 QGELVKCAISIAPVTDFKYYDS----AYTERYL--GQPAENLQGYINTNVIPHARNVT-NVKYLLAHGERDDNVHYQNSA 777
Cdd:pfam00326  85 RPDLFKAAVAHVPVVDWLAYMSdtslPFTERYMewGNPWDNEEGYDYLSPYSPADNVKvYPPLLLIHGLLDDRVPPWQSL 164

                         170       180
                  ....*....|....*....|....
gi 17550672   778 RWSEALQQNGIHFTQLVYANEAHS 801
Cdd:pfam00326 165 KLVAALQRKGVPFLLLIFPDEGHG 188
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
576-817 1.30e-41

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 152.09  E-value: 1.30e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672 576 LKLPSGIDGHYMMLTPAnllDGAKIPLLLDIYGGPDSKQVFqktpTAHAIQIVSQYDIAYARIDVRGTGGRGwdvkeavy 655
Cdd:COG1506   2 FKSADGTTLPGWLYLPA---DGKKYPVVVYVHGGPGSRDDS----FLPLAQALASRGYAVLAPDYRGYGESA-------- 66

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672 656 RKLGDAEVVDTLDMIRAFINTfGFIDEDRIAVMGWSYGGFLTSKIAIKDQgELVKCAISIAPVTDFKYYD---SAYTERY 732
Cdd:COG1506  67 GDWGGDEVDDVLAAIDYLAAR-PYVDPDRIGIYGHSYGGYMALLAAARHP-DRFKAAVALAGVSDLRSYYgttREYTERL 144

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672 733 LGQPAENLQGYINTNVIPHARNVTnVKYLLAHGERDDNVHYQNSARWSEALQQNGIHFTQLVYANEAHSLSHKLF-HLYG 811
Cdd:COG1506 145 MGGPWEDPEAYAARSPLAYADKLK-TPLLLIHGEADDRVPPEQAERLYEALKKAGKPVELLVYPGEGHGFSGAGApDYLE 223


                ....*.
gi 17550672 812 EVQRFL 817
Cdd:COG1506 224 RILDFL 229
COG4099 COG4099
Predicted peptidase [General function prediction only];
662-800 4.88e-10

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 60.75  E-value: 4.88e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672 662 EVVDTLDMIRAFINTFGfIDEDRIAVMGWSYGGFLTSKIAIKdQGELVKCAISIAPVTDFKYydsayterylgqpaenlq 741
Cdd:COG4099 105 ALDAVLALLDDLIAEYR-IDPDRIYLTGLSMGGYGTWDLAAR-YPDLFAAAVPICGGGDPAN------------------ 164

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17550672 742 gyintnviphARNVTNVKYLLAHGERDDNVHYQNSARWSEALQQNG--IHFTqlVYANEAH 800
Cdd:COG4099 165 ----------AANLKKVPVWIFHGAKDDVVPVEESRAMVEALKAAGadVKYT--EYPGVGH 213
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
655-800 2.70e-08

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 54.88  E-value: 2.70e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672 655 YRKLGDA-------EVVDTLDMIRAFINTFGfIDEDRIAVMGWSYGGFLTSKIAI--KDQGE-LVKCAISIAPVTDFKYy 724
Cdd:COG0657  52 YRLAPEHpfpaaleDAYAALRWLRANAAELG-IDPDRIAVAGDSAGGHLAAALALraRDRGGpRPAAQVLIYPVLDLTA- 129

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17550672 725 dSAYTERYLGQPaenlqgyintnviPHarnvtnvkyLLAHGERDDNVhyQNSARWSEALQQNGIHFTQLVYANEAH 800
Cdd:COG0657 130 -SPLRADLAGLP-------------PT---------LIVTGEADPLV--DESEALAAALRAAGVPVELHVYPGGGH 180
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
638-801 1.28e-07

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 53.43  E-value: 1.28e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672 638 IDVRGTGGRGWDVKEA--VYRKLGDAEVVDTLDMIRAFINTFGFIDEDRIAVMGWSYGGFLTSKIAikDQGELVKCAISI 715
Cdd:COG0412  62 PDLYGRGGPGDDPDEAraLMGALDPELLAADLRAALDWLKAQPEVDAGRVGVVGFCFGGGLALLAA--ARGPDLAAAVSF 139

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672 716 APvtdfkyydsayterylgqpaenlqGYINTNVIPHARNVTnVKYLLAHGERDDNVHYQNSARWSEALQQNGIHFTQLVY 795
Cdd:COG0412 140 YG------------------------GLPADDLLDLAARIK-APVLLLYGEKDPLVPPEQVAALEAALAAAGVDVELHVY 194


                ....*.
gi 17550672 796 ANEAHS 801
Cdd:COG0412 195 PGAGHG 200
LpqC COG3509
Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and ...
 580-782 1.42e-05

Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and metabolism];


Pssm-ID: 442732 [Multi-domain]  Cd Length: 284  Bit Score: 47.69  E-value: 1.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672 580 SGIDGHYMMLTPANLLDGAKIPLLLDIYGGpdskqvfqkTPTAHAIQIVSQYDiAYARID---------VRGTGGRGWDV 650
Cdd:COG3509  33 GGGTRTYRLYVPAGYDGGAPLPLVVALHGC---------GGSAADFAAGTGLN-ALADREgfivvypegTGRAPGRCWNW 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672 651 KEAVYRKLGDAEVVDTLDMIRAFINTFGfIDEDRIAVMGWSYGGFLTSKIAikdqgelvkCAIS-----IAPVtdfkyyd 725
Cdd:COG3509 103 FDGRDQRRGRDDVAFIAALVDDLAARYG-IDPKRVYVTGLSAGGAMAYRLA---------CEYPdvfaaVAPV------- 165

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17550672 726 sayterylgqpAENLQGYINTNVIPHARNVTnvkYLLAHGERDDNVHYQNS----ARWSEA 782
Cdd:COG3509 166 -----------AGLPYGAASDAACAPGRPVP---VLVIHGTADPTVPYAGAeetlAQWAAL 212
YpfH COG0400
Predicted esterase [General function prediction only];
644-803 2.26e-05

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 46.05  E-value: 2.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672 644 GGRGWDVKEAVYRKLGDAEVVDTLDMIRAFINT----FGfIDEDRIAVMGWSYGGFLTSKIAIKdQGELVKCAISIApvt 719
Cdd:COG0400  47 GGRAWFDLSFLEGREDEEGLAAAAEALAAFIDElearYG-IDPERIVLAGFSQGAAMALSLALR-RPELLAGVVALS--- 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672 720 dfkyydsayterylgqpaenlqGYINTNVIPHARN--VTNVKYLLAHGERDDNVHYQNSARWSEALQQNGIHFTQLVYAN 797
Cdd:COG0400 122 ----------------------GYLPGEEALPAPEaaLAGTPVFLAHGTQDPVIPVERAREAAEALEAAGADVTYREYPG 179


                ....*.
gi 17550672 798 eAHSLS 803
Cdd:COG0400 180 -GHEIS 184
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 601-812 3.25e-05

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 46.34  E-value: 3.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672   601 PLLLDIYGGPDSKQVFQKTPTAHAiqiVSQYDIaYArIDVRGTGG--RGWDvkeavyrkLGDAEVVDTLDMIRAFINTFG 678
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALA---RDGFRV-IA-LDLRGFGKssRPKA--------QDDYRTDDLAEDLEYILEALG 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672   679 FideDRIAVMGWSYGGFLTSKIAIKDQgELVKCAISIAPVTDFKYYDSAyteryLGQPAENLQGYINTNVIPHARNVTNV 758
Cdd:pfam00561  68 L---EKVNLVGHSMGGLIALAYAAKYP-DRVKALVLLGALDPPHELDEA-----DRFILALFPGFFDGFVADFAPNPLGR 138

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17550672   759 KY--LLAHGERDDNVHY----QNSARWSE--ALQQNGIHFTQLVYANEAHSLSHKLFHLYGE 812
Cdd:pfam00561 139 LVakLLALLLLRLRLLKalplLNKRFPSGdyALAKSLVTGALLFIETWSTELRAKFLGRLDE 200
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 601-783 4.39e-05

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 45.38  E-value: 4.39e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672 601 PLLLdIYGGPDSKQVFQktPTAHAIQivSQYD-IAYariDVRGTGGRGWDVkeavyrklGDAEVVDTLDMIRAFINTFGF 679
Cdd:COG0596  25 PVVL-LHGLPGSSYEWR--PLIPALA--AGYRvIAP---DLRGHGRSDKPA--------GGYTLDDLADDLAALLDALGL 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672 680 ideDRIAVMGWSYGGFLTSKIAIKdQGELVKCAISIAPVTDFkYYDSAYTERYLGQP-AENLQGYINTNVIPHARNVTnV 758
Cdd:COG0596  89 ---ERVVLVGHSMGGMVALELAAR-HPERVAGLVLVDEVLAA-LAEPLRRPGLAPEAlAALLRALARTDLRERLARIT-V 162

                       170       180
                ....*....|....*....|....*
gi 17550672 759 KYLLAHGERDDNVHYQNSARWSEAL 783
Cdd:COG0596 163 PTLVIWGEKDPIVPPALARRLAELL 187
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 637-769 7.92e-05

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 45.29  E-value: 7.92e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672 637 RIDVRGTG---GRgwdvkeavYRKLGDAEVVDTLDMIRaFINTFGFIDEDRIAVMGWSYGGFLTSKIAIKDQGelVKCAI 713
Cdd:COG1073  69 AFDYRGYGeseGE--------PREEGSPERRDARAAVD-YLRTLPGVDPERIGLLGISLGGGYALNAAATDPR--VKAVI 137

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17550672 714 SIAPVTDF--------KYYDSAYTERYLGQPAENLQGYINTnvipHARNVTNVKY-----LLAHGERDD 769
Cdd:COG1073 138 LDSPFTSLedlaaqraKEARGAYLPGVPYLPNVRLASLLND----EFDPLAKIEKisrplLFIHGEKDE 202
COG2936 COG2936
Predicted acyl esterase [General function prediction only];
634-728 1.17e-04

Predicted acyl esterase [General function prediction only];


Pssm-ID: 442179 [Multi-domain]  Cd Length: 555  Bit Score: 45.69  E-value: 1.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672 634 AYARIDVRGTGGrgwdvKEAVYRKLGDAEVVDTLDMIrAFINTfgfIDE--DRIAVMGWSYGGFLTSKIAIkDQGELVKC 711
Cdd:COG2936  71 AVVVQDVRGTGG-----SEGEFDPYRVDEQTDGYDTI-DWLAK---QPWsnGKVGMIGISYGGFTQLAAAA-DRPPALKA 140

                        90
                ....*....|....*..
gi 17550672 712 AISIAPVTDFkYYDSAY 728
Cdd:COG2936 141 IVPQAPTSDR-YDDDHY 156
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
637-817 1.57e-04

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 43.84  E-value: 1.57e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672 637 RIDVRGTGGRGwdvkeavyRKLGDAEVVDT-LDMIRAFINTFGFIDEDRIAVMGWSYGGFLTSKIAIkDQGELVKCAISI 715
Cdd:COG2267  60 AFDLRGHGRSD--------GPRGHVDSFDDyVDDLRAALDALRARPGLPVVLLGHSMGGLIALLYAA-RYPDRVAGLVLL 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672 716 APvtdfkyydsAYTERYLGQPAENLqgYINTNVIPHARNVTnVKYLLAHGERDDNVHYQNSARWSEALQQNGihfTQLVY 795
Cdd:COG2267 131 AP---------AYRADPLLGPSARW--LRALRLAEALARID-VPVLVLHGGADRVVPPEAARRLAARLSPDV---ELVLL 195

                       170       180
                ....*....|....*....|....
gi 17550672 796 ANEAHSLSHKLFH--LYGEVQRFL 817
Cdd:COG2267 196 PGARHELLNEPAReeVLAAILAWL 219
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
567-801 4.88e-04

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 42.92  E-value: 4.88e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672 567 DVPNMKFGKLKLPS---GIDGHYMMLTPAN-LLDGAKIPL--LLDiyGGPDSKQVFQKTptAHAIQIVSQYdIAYARI-- 638
Cdd:COG2382  75 DVPHGTVETVTYPSkalGRTRRVWVYLPPGyDNPGKKYPVlyLLD--GGGGDEQDWFDQ--GRLPTILDNL-IAAGKIpp 149

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672 639 ------DVRGTGGRGWDvkEAVYRKLGDAEVVDTLDMIRAfinTFGFIDE-DRIAVMGWSYGGFLTSKIAIKDqGELVKC 711
Cdd:COG2382 150 mivvmpDGGDGGDRGTE--GPGNDAFERFLAEELIPFVEK---NYRVSADpEHRAIAGLSMGGLAALYAALRH-PDLFGY 223

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672 712 AISIAPvtdfkyydsayterYLGQPAENLQGYINTNVIPHARNVTNVKYLLAHGERDDNvhYQNSARWSEALQQNGIHFT 791
Cdd:COG2382 224 VGSFSG--------------SFWWPPGDADRGGWAELLAAGAPKKPLRFYLDVGTEDDL--LEANRALAAALKAKGYDVE 287

                       250
                ....*....|
gi 17550672 792 QLVYaNEAHS 801
Cdd:COG2382 288 YREF-PGGHD 296
PRK05371 PRK05371
x-prolyl-dipeptidyl aminopeptidase; Provisional
 751-820 1.87e-03

x-prolyl-dipeptidyl aminopeptidase; Provisional


Pssm-ID: 235435 [Multi-domain]  Cd Length: 767  Bit Score: 41.91  E-value: 1.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672  751 HARN----VTNVK--YLLAHGERDDNVHYQNSARWSEALQQNGI------HFTQLVYANEAHS----------LSHKLFH 808
Cdd:PRK05371 443 DDRNylkdADKIKasVLVVHGLNDWNVKPKQVYQWWDALPENGVpkklflHQGGHVYPNNWQSidfrdtmnawFTHKLLG 522

                         90
                 ....*....|..
gi 17550672  809 LYGEVQRFLMND 820
Cdd:PRK05371 523 IDNGVENELPAV 534
BD-FAE pfam20434
BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, ...
 680-783 8.20e-03

BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, previously known as bifunctional carbohydrate esterase (CE)), which is active on complex natural xylans and was identified as the basis of a monophyletic clade gathering all homologs identified in PULs (polysaccharide utilization loci) predicted to act on xylan. It adopts an alpha-beta-hydrolase fold with the catalytic triad Ser-Asp-His. This new family of proteins is a new candidate for biomass processing due to its capacity to remove ferulic acid and acetic acid from natural corn and birchwood xylan substrates.


Pssm-ID: 466583 [Multi-domain]  Cd Length: 215  Bit Score: 38.70  E-value: 8.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550672   680 IDEDRIAVMGWSYGGFLTSKIAIK--------DQGEL----------VKCAISIAPVTDFKYYDSAYTERYLGQPAENLQ 741
Cdd:pfam20434  86 IDTNKIALMGFSAGGHLALLAGLSnnnkefegNVGDYtpesskesfkVNAVVDFYGPTDLLDMDSCGTHNDAKSPETLLL 165

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 17550672   742 G---YINTNVIPHARNVTNVK-----YLLAHGERDDNVHYQNSARWSEAL 783
Cdd:pfam20434 166 GappLENPDLAKSASPITYVDkndppFLIIHGDKDPLVPYCQSVLLHEKL 215
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH