Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567707   141 LAASKYGCALFIQFLKQQTSENEVDFWLDCQKFRsSTAKISWKNKEVHRILDQFLSSSAPRKIDMETSILARCMEYVEHI 220
Cdd:pfam00615   5 LLEDQPGRRLFRQFLESEFSEENLEFWLACEEFK-KADPDEERLKKAKEIYNEFLAPGSPKEINLDSDLREEIRENLEKE 83

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 17567707   221 EgWKYTFDVAQAYVGLKFPKESHKKFLEDPLYLDL 255
Cdd:pfam00615  84 P-TRDLFDEAQAEVYELMEKDSYPRFLKSPLYLRL 117

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567707   141 LAASKYGCALFIQFLKQQTSENEVDFWLDCQKFRsSTAKISWKNKEVHRILDQFLSSSAPRKIDMETSILARCMEYVEHI 220
Cdd:pfam00615   5 LLEDQPGRRLFRQFLESEFSEENLEFWLACEEFK-KADPDEERLKKAKEIYNEFLAPGSPKEINLDSDLREEIRENLEKE 83

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 17567707   221 EgWKYTFDVAQAYVGLKFPKESHKKFLEDPLYLDL 255
Cdd:pfam00615  84 P-TRDLFDEAQAEVYELMEKDSYPRFLKSPLYLRL 117

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567707 143 ASKYGCALFIQFLKQQTSENEVDFWLDCQKFRSSTAKISWKNKEVHRILDQFLSSSAPRKIDMETSILARCMEYVEHIEG 222
Cdd:cd07440   2 RDPYGLEYFRQFLKSEHCEENLEFWLAVEKFKKTTSSDEELKSKAKEIYDKYISKDAPKEINIPESIREEIEENLEEPYP 81

                        90       100       110
                ....*....|....*....|....*....|..
gi 17567707 223 WKYTFDVAQAYVGLKFPKESHKKFLEDPLYLD 254
Cdd:cd07440  82 DPDCFDEAQEHILNLLEKDSYPRFLKSDLYLK 113

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567707   141 LAASKYGCALFIQFLKQQTSENEVDFWLDCQKFRsSTAKISWKNKEVHRILDQFLSSSAPRKIDMETSILARCMEYVEHI 220
Cdd:pfam00615   5 LLEDQPGRRLFRQFLESEFSEENLEFWLACEEFK-KADPDEERLKKAKEIYNEFLAPGSPKEINLDSDLREEIRENLEKE 83

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 17567707   221 EgWKYTFDVAQAYVGLKFPKESHKKFLEDPLYLDL 255
Cdd:pfam00615  84 P-TRDLFDEAQAEVYELMEKDSYPRFLKSPLYLRL 117

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567707 143 ASKYGCALFIQFLKQQTSENEVDFWLDCQKFRSSTAKISWKNKEVHRILDQFLSSSAPRKIDMETSILARCMEYVEHIEG 222
Cdd:cd07440   2 RDPYGLEYFRQFLKSEHCEENLEFWLAVEKFKKTTSSDEELKSKAKEIYDKYISKDAPKEINIPESIREEIEENLEEPYP 81

                        90       100       110
                ....*....|....*....|....*....|..
gi 17567707 223 WKYTFDVAQAYVGLKFPKESHKKFLEDPLYLD 254
Cdd:cd07440  82 DPDCFDEAQEHILNLLEKDSYPRFLKSDLYLK 113

Regulator of G protein signaling (RGS) domain found in the RGS8 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS8 protein. RGS8 is a member of R4/RGS subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS8 is involved in G-protein-gated potassium channels regulation and predominantly expressed in the brain. RGS8 also is selectively expressed in the hematopoietic system (NK cells).

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567707 127 SFQEIENWKKSPGLLAASKYGCALFIQFLKQQTSENEVDFWLDCQKFRS--STAKISWKnkeVHRILDQFLSSSAPRK-- 202
Cdd:cd08711   1 STEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKtrSTAKLVSK---AHRIFEEFVDVQAPREvn 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 17567707 203 IDMETSILARcmeyVEHIEGWKYTFDVAQAYVGLKFPKESHKKFLEDPLYLD 254
Cdd:cd08711  78 IDFQTREATR----KNLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLD 125

Regulator of G protein signaling (RGS) domain found in the RGS3 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS3 protein. RGS3 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. RGS3 induces apoptosis when overexpressed and is involved in cell migration through interaction with the Ephrin receptor. RGS3 exits as several splice isoforms and interacts with neuroligin, estrogen receptor-alpha, and 14-3-3 outside of the GPCR pathways.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567707 140 LLAASKYGCALFIQFLKQQTSENEVDFWLDCQKFRS--STAKISWKNKevhRILDQFLSSSAPRKIDMETSILARCMEYV 217
Cdd:cd08713   3 KLLLHKYGLAVFRAFLQTEFSEENLEFWLACEEYKKikSQSKMASRAK---KIFAEYIAIQSCKEVNLDSYTREHTKENL 79

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 17567707 218 EHIEgwKYTFDVAQAYVGLKFPKESHKKFLEDPLYLD 254
Cdd:cd08713  80 QNPT--RGCFDLAQKRIYGLMEKDSYPRFLRSDLYQD 114

Regulator of G protein signaling (RGS) domain found in the RGS18 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS18 protein. RGS18 is a member of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS18 is a member of the R4/RGS subfamily and is expressed predominantly in osteoclasts where it acts as a negative regulator of the acidosis-induced osteoclastogenic OGR1/NFAT signaling pathway. RANKL (receptor activator of nuclear factor B ligand) stimulates osteoclastogenesis by inhibiting expression of RGS18.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567707 141 LAASKYGCALFIQFLKQQTSENEVDFWLDCQKFRSS--TAKISWKNKEVHrilDQFLSSSAPRKIDMETSILARCMEYVE 218
Cdd:cd08712   4 LLSHKDGLEAFTRFLKTEFSEENIEFWIACEDYKKSktPQQIHLKAKAIY---EKFIQTDAPKEVNLDFHTKEVTTNSIE 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 17567707 219 HIEgwKYTFDVAQAYVGLKFPKESHKKFLEDPLYLD 254
Cdd:cd08712  81 QPT--LTSFDAAQSRVYQLMEQDSYPRFLKSDIYLD 114

Regulator of G protein signaling (RGS) domain found in the RGS5 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS5 protein. RGS5 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Two splice isoforms of RGS5 has been found: RGS5L (long) which is expressed in smooth muscle cells (pericytes) and heart and RGS5S (short) which is highly expressed in the ciliary body of the eye, kidney, brain, spleen, skeletal muscle, and small intestine. Outside of the GPCR pathway, RGS5 interacts with the 14-3-3 protein.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567707 141 LAASKYGCALFIQFLKQQTSENEVDFWLDCQKFR--SSTAKISWKNKevhRILDQFLSSSAPRKIDMETSILARCMEYVe 218
Cdd:cd08717   4 LLQNSYGLASFKSFLKSEFSEENIEFWEACEDYKktKSPLKMATKAK---KIYEEFIQTEAPKEVNIDHFTKDVTMKNL- 79

                        90       100       110
                ....*....|....*....|....*....|....
gi 17567707 219 hIEGWKYTFDVAQAYVGLKFPKESHKKFLEDPLY 252
Cdd:cd08717  80 -VEPSSSSFDLAQKRIFALMEKDSLPRFVRSEFY 112

Regulator of G protein signaling (RGS) domain found in the RGS1 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS1 protein. RGS1 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS 1 is expressed predominantly in hematopoietic compartments, including T and B lymphocytes, and may play a major role in chemokine-mediated homing of lymphocytes to secondary lymphoid organs. In addition, RGS1 interacts with calmodulin and 14-3-3 protein outside of the GPCR pathway.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567707 141 LAASKYGCALFIQFLKQQTSENEVDFWLDCQKFRSSTAKISWKNKEvhRILDQFLSSSAPRKIDMETSILARCMEYVEhi 220
Cdd:cd08715   4 LLASQTGQNVFRSFLKSEFSEENIEFWLACEDYKKTESDLLPCKAE--EIYKEFVQSDAAKQINIDFRTRESTAKKIK-- 79

                        90       100       110
                ....*....|....*....|....*....|....*
gi 17567707 221 EGWKYTFDVAQAYVGLKFPKESHKKFLEDPLYLDL 255
Cdd:cd08715  80 APTPTCFDEAQKVIYILMERDSYPRFLKSDIYLNL 114

Regulator of G protein signaling (RGS) domain found in the RGS4 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS4 protein. RGS4 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. RGS4 is expressed widely in brain including prefrontal cortex, striatum, locus coeruleus (LC), and hippocampus and has been implicated in regulation of opioid, cholinergic, and serotonergic signaling. Dysfunctions in RGS4 proteins are involved in etiology of Parkinson's disease, addiction, and schizophrenia. RGS4 also is up-regulated in the failing human heart. RGS4 interacts with many binding partners outside of GPCR pathways, including calmodulin, COP, Kir3, PIP, calcium/CaM, PA, ErbB3, and 14-3-3.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567707 147 GCALFIQFLKQQTSENEVDFWLDCQKFRS--STAKISWKNKevhRILDQFLSSSAPRKIDMETSILARCMEYVEhiEGWK 224
Cdd:cd08714  10 GLAAFKAFLKSEYSEENIDFWVSCEDYKKtkSPSKLSPKAR---KIYEEFISVQATKEVNLDSCTREETSRNML--EPTI 84

                        90       100       110
                ....*....|....*....|....*....|
gi 17567707 225 YTFDVAQAYVGLKFPKESHKKFLEDPLYLD 254
Cdd:cd08714  85 SCFDEAQKKIFTLMEKDSYRRFLKSRFYLD 114

Regulator of G protein signaling (RGS) domain found in the RGS19 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS19 protein (also known as GAIP), a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by RGS domains, which accelerate GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, resulting in a reassociation of the alpha-subunit with the beta-gamma-dimer and an inhibition of downstream activity. As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins includes RGS17, RGS20, and its splice variant Ret-RGS. RGS19 participates in regulation of dopamine receptor D2R and D3R, as well as beta-adrenergic receptors .

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567707 134 WKKSPGLLAASKYGCALFIQFLKQQTSENEVDFWLDCQKFRSSTAKISWKNKeVHRILDQFLSSSAPRKIDMETSI---L 210
Cdd:cd08745   1 WAQSFDKLMKSPAGRNVFREFLRTEYSEENMLFWLACEELKAEANKHVIDEK-ARLIYEDYISILSPKEVSLDSRVregI 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 17567707 211 ARCMEyvehiEGWKYTFDVAQAYVGLKFPKESHKKFLEDPLY 252
Cdd:cd08745  80 NRKMQ-----EPSSHTFDDAQLQIYTLMHRDSYPRFLNSPIY 116

Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS13 protein. RGS13 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS13 is predominantly expressed in T and B lymphocytes and in mast cells, and plays a role in adaptive immune responses. RGS13 also found in Rgs13, which is also expressed in dendritic cells and in neuroendocrine cells of the thymus, gastrointestinal, and respiratory tracts. Outside of the GPCR pathway, RGS5 interacts with the PIP3 protein.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567707 141 LAASKYGCALFIQFLKQQTSENEVDFWLDCQKFRSSTAKisWKNKEVHRIL-DQFLSSSAPRKIDMETSILARCMEYVEh 219
Cdd:cd08716   4 LMATKYGPIIYATYLKTEHSDENIEFWLACETYKKIASQ--RKRISMARKLfASYIQPQAPREINIDSPTRKAIIRNIQ- 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 17567707 220 iEGWKYTFDVAQAYVGLKFPKESHKKFLEDPLY 252
Cdd:cd08716  81 -EPTQSCFDEAQRIVYMHMERDSYPRFLESKFY 112

Regulator of G protein signaling (RGS) domain found in the RGS10 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS10 protein. RGS10 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS10 belong to the R12 RGS subfamily, which includes RGS12 and RGS14, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS10 exists in 2 splice isoforms. RGS10A is specifically expressed in osteoclasts and is a key component in the RANKL signaling mechanism for osteoclast differentiation, whereas RGS10B expressed in brain and in immune tissues and has been implicated in diverse processes including: promoting of dopaminergic neuron survival via regulation of the microglial inflammatory response, modulation of presynaptic and postsynaptic G-protein signalling, as well as a possible role in regulation of gene expression.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567707 147 GCALFIQFLKQQTSENEVDFWLDCQKFRSSTAKISWKNKeVHRILDQFLSSSAPRKIDME 206
Cdd:cd08741  10 GVKRFREFLKKEFSEENVLFWLACEDFKKMQDKTQMQEK-AKEIYMTFLSSKASSQVNVE 68

Regulator of G protein signaling (RGS) domain found in the RGS7 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS7 protein, a member of R7 subfamily of the RGS protein family. RGS is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Other members of the R7 subfamily (Neuronal RGS) include: RGS6, RGS9, and RGS11, all of which are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes such as vision and motor control. Additionally they have been implicated in many neurological conditions such as anxiety, schizophrenia, and drug dependence. R7 RGS proteins are key modulators of the pharmacological effects of drugs involved in the development of tolerance and addiction. In addition, RGS7 was found to bind a component of the synaptic fusion complex, snapin, and some other proteins outside of G protein signaling pathways.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567707 151 FIQFLKQQTSENEVDFWLDCQKFRSStaKISWKNKEVHRILDQFLSSSAPRKIDMETSILARCMEYVEhiEGWKYTFDVA 230
Cdd:cd08738  22 FLKFLESEFSSENLRFWLAVEDLKKR--PIREVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVK--DPGRYTFEDA 97

                        90       100
                ....*....|....*....|..
gi 17567707 231 QAYVGLKFPKESHKKFLEDPLY 252
Cdd:cd08738  98 QEHIYKLMKSDSYPRFIRSSAY 119

Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567707 148 CALFIQFLKQQTS--ENEVDFWLDCQKFRS---STAKISWKNKEVHRILDQFLSSSAPR--KIDMETSILARCMEYVEHI 220
Cdd:cd08725   7 SEQFQRFVSLKGEelENDLLFWLEVQKYKDlchSHSDEHIIQNKITAIISCFIDSSVPPalQIDIPPEIANRILEHRREL 86

                        90
                ....*....|....
gi 17567707 221 EGwkYTFDVAQAYV 234
Cdd:cd08725  87 GP--YIFREAQLTV 98