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Conserved domains on  [gi|71993341|ref|NP_510683|]
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G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

Protein Classification

serpentine receptor Sra family protein( domain architecture ID 27938)

serpentine receptor Sra family protein such as Sra, Srab, Srb, and Sre; they belong to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Gene Ontology:  GO:0004930|GO:0007606
PubMed:  18050473|7585938

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Srab super family cl11607
Serpentine type 7TM GPCR receptor class ab chemoreceptor; Chemoreception is mediated in ...
 23-144 6.33e-04

Serpentine type 7TM GPCR receptor class ab chemoreceptor; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srab is part of the Sra superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The expression pattern of the srab genes is biologically intriguing. Of the six promoters successfully expressed in transgenic organizms, one was exclusively expressed in the tail phasmid neurons, two were exclusively expressed in a head amphid neuron, and two were expressed both in the head and tail neurons as well as a limited number of other cells.


The actual alignment was detected with superfamily member pfam10292:

Pssm-ID: 386183  Cd Length: 324  Bit Score: 41.10  E-value: 6.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993341    23 STFMEYSILLRLLTAPLATMGMGLLSATIVKTKGIHINTKVILLVLCISAIICNTGITV----DCLYKFFISNV---MPD 95
Cdd:pfam10292  13 SSFLRLSLLFNLILSIIALPVLIWALWSIKKSKLFHFNTRIIFQIHLFGFLIHCFGRIIlhglDLYNYFVPLDGcdmIPS 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 71993341    96 YMQCdfqvfspqygLVIRHIEMLGAMCLSTSSVALAVERTVATIFYRNY 144
Cdd:pfam10292  93 IYRC----------FVLRLMYNFGLFLISATTVSLVIERYIATYRSSKY 131
 
Name Accession Description Interval E-value
7TM_GPCR_Srab pfam10292
Serpentine type 7TM GPCR receptor class ab chemoreceptor; Chemoreception is mediated in ...
 23-144 6.33e-04

Serpentine type 7TM GPCR receptor class ab chemoreceptor; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srab is part of the Sra superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The expression pattern of the srab genes is biologically intriguing. Of the six promoters successfully expressed in transgenic organizms, one was exclusively expressed in the tail phasmid neurons, two were exclusively expressed in a head amphid neuron, and two were expressed both in the head and tail neurons as well as a limited number of other cells.


Pssm-ID: 370953  Cd Length: 324  Bit Score: 41.10  E-value: 6.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993341    23 STFMEYSILLRLLTAPLATMGMGLLSATIVKTKGIHINTKVILLVLCISAIICNTGITV----DCLYKFFISNV---MPD 95
Cdd:pfam10292  13 SSFLRLSLLFNLILSIIALPVLIWALWSIKKSKLFHFNTRIIFQIHLFGFLIHCFGRIIlhglDLYNYFVPLDGcdmIPS 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 71993341    96 YMQCdfqvfspqygLVIRHIEMLGAMCLSTSSVALAVERTVATIFYRNY 144
Cdd:pfam10292  93 IYRC----------FVLRLMYNFGLFLISATTVSLVIERYIATYRSSKY 131
 
Name Accession Description Interval E-value
7TM_GPCR_Srab pfam10292
Serpentine type 7TM GPCR receptor class ab chemoreceptor; Chemoreception is mediated in ...
 23-144 6.33e-04

Serpentine type 7TM GPCR receptor class ab chemoreceptor; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srab is part of the Sra superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The expression pattern of the srab genes is biologically intriguing. Of the six promoters successfully expressed in transgenic organizms, one was exclusively expressed in the tail phasmid neurons, two were exclusively expressed in a head amphid neuron, and two were expressed both in the head and tail neurons as well as a limited number of other cells.


Pssm-ID: 370953  Cd Length: 324  Bit Score: 41.10  E-value: 6.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993341    23 STFMEYSILLRLLTAPLATMGMGLLSATIVKTKGIHINTKVILLVLCISAIICNTGITV----DCLYKFFISNV---MPD 95
Cdd:pfam10292  13 SSFLRLSLLFNLILSIIALPVLIWALWSIKKSKLFHFNTRIIFQIHLFGFLIHCFGRIIlhglDLYNYFVPLDGcdmIPS 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 71993341    96 YMQCdfqvfspqygLVIRHIEMLGAMCLSTSSVALAVERTVATIFYRNY 144
Cdd:pfam10292  93 IYRC----------FVLRLMYNFGLFLISATTVSLVIERYIATYRSSKY 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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