NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|392928315|ref|NP_510768|]
View 

MADF domain-containing protein [Caenorhabditis elegans]

Protein Classification

Lin-8 superfamily-containing protein( domain architecture ID 5238)

Lin-8 superfamily-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Lin-8 super family cl04022
Ras-mediated vulval-induction antagonist; LIN-8 is a nuclear protein, present at the sites of ...
 9-229 9.41e-34

Ras-mediated vulval-induction antagonist; LIN-8 is a nuclear protein, present at the sites of transcriptional repressor complexes, which interacts with LIN-35 Rb. Lin35 Rb is a product of the class B synMuv gene lin-35 which silences genes required for vulval specification through chromatin modification and remodelling. The biological role of the interaction has not yet been determined however predictions have been made. The interaction shows that class A synMuv genes control vulval induction through the transcriptional regulation of gene expression. LIN-8 normally functions as part of a protein complex however when the complex is absent, other family members can partially replace LIN-8 activity.


The actual alignment was detected with superfamily member pfam03353:

Pssm-ID: 397436  Cd Length: 309  Bit Score: 123.25  E-value: 9.41e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392928315    9 ITQKKYCELEKRNHVIDKKKKVIVKTALFTLMEKYPCFWQHNVRGSLDQWILVRAEVYEQTGEVVPERELREMFTMAKKF 88
Cdd:pfam03353   1 ITLKEYIELEKKKFYKDATKDDNLKKVVLSLIEKRPEIWDSKAKSQPKKWEMVGIEVYKRTGKIVSVKQLRSVFKTAKDS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392928315   89 LKTKIMKSIRN-SIDHDTMEAQLRQWKFFPFIGYYYKSLAKFESTMRKKQAENGLVSAALMEDDTLGEDTEEDISSEEDD 167
Cdd:pfam03353  81 LRRKLRTCILKkKLDPEETEEELWKWEYYGFFRFYRETLGQWEAELRKEVWTGEAQDADDDDIIFDGYFEGEEGEDTEDD 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392928315  168 DIVVVDEIIRVQ----SPRSCIQNVKPQ---QSASSPPAVRQSAIVTPSASENNRTSNAASNGQCSQLR 229
Cdd:pfam03353 161 VPFSVEEEAYEQgdmdGPESEVEEVSPQqmaQQYDNEPEPPLEEPTVEFFEANAALRMADQNFGHGQLS 229
 
Name Accession Description Interval E-value
Lin-8 pfam03353
Ras-mediated vulval-induction antagonist; LIN-8 is a nuclear protein, present at the sites of ...
 9-229 9.41e-34

Ras-mediated vulval-induction antagonist; LIN-8 is a nuclear protein, present at the sites of transcriptional repressor complexes, which interacts with LIN-35 Rb. Lin35 Rb is a product of the class B synMuv gene lin-35 which silences genes required for vulval specification through chromatin modification and remodelling. The biological role of the interaction has not yet been determined however predictions have been made. The interaction shows that class A synMuv genes control vulval induction through the transcriptional regulation of gene expression. LIN-8 normally functions as part of a protein complex however when the complex is absent, other family members can partially replace LIN-8 activity.


Pssm-ID: 397436  Cd Length: 309  Bit Score: 123.25  E-value: 9.41e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392928315    9 ITQKKYCELEKRNHVIDKKKKVIVKTALFTLMEKYPCFWQHNVRGSLDQWILVRAEVYEQTGEVVPERELREMFTMAKKF 88
Cdd:pfam03353   1 ITLKEYIELEKKKFYKDATKDDNLKKVVLSLIEKRPEIWDSKAKSQPKKWEMVGIEVYKRTGKIVSVKQLRSVFKTAKDS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392928315   89 LKTKIMKSIRN-SIDHDTMEAQLRQWKFFPFIGYYYKSLAKFESTMRKKQAENGLVSAALMEDDTLGEDTEEDISSEEDD 167
Cdd:pfam03353  81 LRRKLRTCILKkKLDPEETEEELWKWEYYGFFRFYRETLGQWEAELRKEVWTGEAQDADDDDIIFDGYFEGEEGEDTEDD 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392928315  168 DIVVVDEIIRVQ----SPRSCIQNVKPQ---QSASSPPAVRQSAIVTPSASENNRTSNAASNGQCSQLR 229
Cdd:pfam03353 161 VPFSVEEEAYEQgdmdGPESEVEEVSPQqmaQQYDNEPEPPLEEPTVEFFEANAALRMADQNFGHGQLS 229
 
Name Accession Description Interval E-value
Lin-8 pfam03353
Ras-mediated vulval-induction antagonist; LIN-8 is a nuclear protein, present at the sites of ...
 9-229 9.41e-34

Ras-mediated vulval-induction antagonist; LIN-8 is a nuclear protein, present at the sites of transcriptional repressor complexes, which interacts with LIN-35 Rb. Lin35 Rb is a product of the class B synMuv gene lin-35 which silences genes required for vulval specification through chromatin modification and remodelling. The biological role of the interaction has not yet been determined however predictions have been made. The interaction shows that class A synMuv genes control vulval induction through the transcriptional regulation of gene expression. LIN-8 normally functions as part of a protein complex however when the complex is absent, other family members can partially replace LIN-8 activity.


Pssm-ID: 397436  Cd Length: 309  Bit Score: 123.25  E-value: 9.41e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392928315    9 ITQKKYCELEKRNHVIDKKKKVIVKTALFTLMEKYPCFWQHNVRGSLDQWILVRAEVYEQTGEVVPERELREMFTMAKKF 88
Cdd:pfam03353   1 ITLKEYIELEKKKFYKDATKDDNLKKVVLSLIEKRPEIWDSKAKSQPKKWEMVGIEVYKRTGKIVSVKQLRSVFKTAKDS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392928315   89 LKTKIMKSIRN-SIDHDTMEAQLRQWKFFPFIGYYYKSLAKFESTMRKKQAENGLVSAALMEDDTLGEDTEEDISSEEDD 167
Cdd:pfam03353  81 LRRKLRTCILKkKLDPEETEEELWKWEYYGFFRFYRETLGQWEAELRKEVWTGEAQDADDDDIIFDGYFEGEEGEDTEDD 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392928315  168 DIVVVDEIIRVQ----SPRSCIQNVKPQ---QSASSPPAVRQSAIVTPSASENNRTSNAASNGQCSQLR 229
Cdd:pfam03353 161 VPFSVEEEAYEQgdmdGPESEVEEVSPQqmaQQYDNEPEPPLEEPTVEFFEANAALRMADQNFGHGQLS 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH