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Conserved domains on  [gi|17550772|ref|NP_510807|]
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F-box domain-containing protein [Caenorhabditis elegans]

Protein Classification

F-box protein( domain architecture ID 17778750)

F-box protein is the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins; similar to Caenorhabditis elegans F-box domain-containing protein

Gene Ontology:  GO:0000209|GO:0031146|GO:0019005|GO:0005515
PubMed:  10581972|31898225

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 141-277 7.90e-47

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


:

Pssm-ID: 396410  Cd Length: 141  Bit Score: 154.27  E-value: 7.90e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550772   141 TWFRDTFNPENMLHTKKVFLGNLEFNDVITIISTLKPGFLQKIDYASLLQHERSHEVFELEQWKQAKEVISPMSSFRSFP 220
Cdd:pfam01827   5 ESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIELSSESDEDQFEEIVELEQWKNAKSLKIEGSSLSSFP 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 17550772   221 IENMFHLSRFWLGFPGLSISDAIKIRDILLKSAHFKNGIIDLKDEMTPEVARVFNPN 277
Cdd:pfam01827  85 IEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDLNPIEIAKVFDPD 141
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 18-62 6.52e-08

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438921  Cd Length: 46  Bit Score: 48.25  E-value: 6.52e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 17550772  18 LIELPTEMLTEIIKRVNPINRLALRKVCRILRKIVD-ENPGVESVT 62
Cdd:cd22150   1 LSDLPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDnQDPGFKKIS 46
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 141-277 7.90e-47

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 154.27  E-value: 7.90e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550772   141 TWFRDTFNPENMLHTKKVFLGNLEFNDVITIISTLKPGFLQKIDYASLLQHERSHEVFELEQWKQAKEVISPMSSFRSFP 220
Cdd:pfam01827   5 ESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIELSSESDEDQFEEIVELEQWKNAKSLKIEGSSLSSFP 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 17550772   221 IENMFHLSRFWLGFPGLSISDAIKIRDILLKSAHFKNGIIDLKDEMTPEVARVFNPN 277
Cdd:pfam01827  85 IEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDLNPIEIAKVFDPD 141
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 18-62 6.52e-08

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 48.25  E-value: 6.52e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 17550772  18 LIELPTEMLTEIIKRVNPINRLALRKVCRILRKIVD-ENPGVESVT 62
Cdd:cd22150   1 LSDLPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDnQDPGFKKIS 46
FBOX smart00256
A Receptor for Ubiquitination Targets;
21-56 9.94e-08

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 47.43  E-value: 9.94e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 17550772     21 LPTEMLTEIIKRVNPINRLALRKVCRILRKIVDENP 56
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHD 36
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 18-53 2.58e-05

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 40.60  E-value: 2.58e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 17550772    18 LIELPTEMLTEIIKRVNPINRLALRKVCRILRKIVD 53
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVD 36
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 141-277 7.90e-47

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 154.27  E-value: 7.90e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550772   141 TWFRDTFNPENMLHTKKVFLGNLEFNDVITIISTLKPGFLQKIDYASLLQHERSHEVFELEQWKQAKEVISPMSSFRSFP 220
Cdd:pfam01827   5 ESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIELSSESDEDQFEEIVELEQWKNAKSLKIEGSSLSSFP 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 17550772   221 IENMFHLSRFWLGFPGLSISDAIKIRDILLKSAHFKNGIIDLKDEMTPEVARVFNPN 277
Cdd:pfam01827  85 IEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDLNPIEIAKVFDPD 141
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 18-62 6.52e-08

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 48.25  E-value: 6.52e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 17550772  18 LIELPTEMLTEIIKRVNPINRLALRKVCRILRKIVD-ENPGVESVT 62
Cdd:cd22150   1 LSDLPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDnQDPGFKKIS 46
FBOX smart00256
A Receptor for Ubiquitination Targets;
21-56 9.94e-08

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 47.43  E-value: 9.94e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 17550772     21 LPTEMLTEIIKRVNPINRLALRKVCRILRKIVDENP 56
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHD 36
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 18-53 2.58e-05

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 40.60  E-value: 2.58e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 17550772    18 LIELPTEMLTEIIKRVNPINRLALRKVCRILRKIVD 53
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVD 36
F-box_FBXO1 cd22082
F-box domain found in F-box only protein 1 (FBXO1) and similar proteins; FBXO1, also called ...
 17-66 7.66e-03

F-box domain found in F-box only protein 1 (FBXO1) and similar proteins; FBXO1, also called FBX1, or cyclin-F, is a substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438854  Cd Length: 52  Bit Score: 34.14  E-value: 7.66e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 17550772  17 TLIELPTEMLTEIIKRVNPINRLALRKVCRILRKIVDENPGVESVTSAVD 66
Cdd:cd22082   1 TLWSLPEEVLLHILKGLPIKDLLNMRAVHSRFKDLIDSNPSLWANASFQG 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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