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Conserved domains on  [gi|24641507|ref|NP_511137|]
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tenascin accessory, isoform D [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tox-GHH pfam15636
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ...
 2889-2966 1.60e-38

GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.


:

Pssm-ID: 464783  Cd Length: 78  Bit Score: 139.28  E-value: 1.60e-38
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24641507   2889 KEQQRLMHHAKLTAVRKAWHREKEALRSGLTTALEWSQQETDEILKQSYANNYEGEYIHDVNLYPELAEDPYNIKFVK 2966
Cdd:pfam15636    1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1239-1544 7.35e-35

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd14953:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 323  Bit Score: 137.66  E-value: 7.35e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1239 NGVAKDAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTILQL----------SATQVSYQYYLAVSPAdGHLYI 1306
Cdd:cd14953   14 GGGGTAARFNSPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTgtagfadgggAAAQFNTPSGVAVDAA-GNLYV 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1307 SDPERHqilrlvRLEKVkDPSINSDPVVGSGQRcipgdeGNCGDGGpALLARLSHPKGLAIAADRTMYIADGTN--IRAV 1384
Cdd:cd14953   93 ADTGNH------RIRKI-TPDGVVSTLAGTGTA------GFSDDGG-ATAAQFNYPTGVAVDAAGNLYVADTGNhrIRKI 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1385 DPKGVIHTLIGhhghhnhwSPAPCS---GTlmANQAQLQWPTGLALSPlDGSLhFIDDRL---VLRLTSDMKIRVVAGTp 1458
Cdd:cd14953  159 TPDGVVTTVAG--------TGGAGYagdGP--ATAAQFNNPTGVAVDA-AGNL-YVADRGnhrIRKITPDGVVTTVAGT- 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1459 lhcsnGGQDGRVNKTGADNVLGTVLAMAFSPFGNLYIADSDSRRvnsIRVVDTAGNMRYFAGKQEGTgsqtcdcaigGGS 1538
Cdd:cd14953  226 -----GTAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGNHR---IRKITPAGVVTTVAGGGAGF----------SGD 287


                 ....*.
gi 24641507 1539 NGSATN 1544
Cdd:cd14953  288 GGPATS 293
RhsA COG3209
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ...
 1983-2632 6.63e-30

Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];


:

Pssm-ID: 442442 [Multi-domain]  Cd Length: 1103  Bit Score: 130.65  E-value: 6.63e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1983 YSVYSLVGDVRNPQQTLNREIWVNQSRVIGVEFDQFTNRETFYDARRTPILIVAYDQSGLPKSYYPTNGYPVNITYDRFN 2062
Cdd:COG3209  375 GGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTAGGTATGTGTGGGGTTAGTDATTTTGG 454

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 2063 RVEGWAWGPAELKYSYDRHGLLSEITSQQDGIVSFVYNDWNLVSEIGLASQRkfvlqYDDAGGLRHVVLPSGTRHSFSMQ 2142
Cdd:COG3209  455 AGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTL-----GGTTTTTAGARGLVVTTGTTLTL 529

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 2143 TSIGFIRCTYTPPGSTRAYLQHYSHAGALLQTILPGDGARIVYRYNAAGQLTEVVHGDGRSEFQYNEATGMPSTVSHTER 2222
Cdd:COG3209  530 GTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTTTTSTAGTTTTT 609

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 2223 ELEY-RWDFEYAAGLLAEERIDYVAKTGLSNAKFSYEYDSQLRVVALQGRIGGQSLPTQAFAYDPRTGRPSLIGQFRFSQ 2301
Cdd:COG3209  610 TSGYtRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGTGTGVTAGLTTLATGGTTVGGGTGT 689

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 2302 PAQNQTQLHDGTASFTRTVDGRFQTQRMALAIHRLEVFRMEFSYGVHGRISQTRTYTRNMAVNSYTNVKNYTWDCDGQLV 2381
Cdd:COG3209  690 TSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTTAGALTYTYDALGRLT 769

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 2382 GVEAQEP-------WGFRYDDNGNLLSLTY-RGNTIPMEYNAQDRIVK-----------FGEGQYKYDARGLVAQ----- 2437
Cdd:COG3209  770 SETTPGGvtqgtytTRYTYDALGRLTSVTYpDGETVTYTYDALGRLTSvitvgsgggtdLQDRTYTYDAAGNITSitdal 849

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 2438 --NAREERFHYNTQGLLVRASKRGRfDVRYYYDHLKRLTTRKDnfGNVTQFFYTNQQRPYEVSQiyspRDGKLMSLTYDD 2515
Cdd:COG3209  850 raGTLTQTYTYDALGRLTSATDPGT-TESYTYDANGNLTSRTD--GGTTTYTYDALGRLVSVTK----PDGTTTTYTYDA 922

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 2516 VGHliyaqvyrhkyyvaTDQSGTPLMLFNQYGEGIREIMRSPFGHIVYDSNPYLYLPIDFCGGILDQVTTLVHMGdGRVY 2595
Cdd:COG3209  923 LGH--------------TDHLGSVRALTDASGQVVWRYDYDPFGNLLAETSGAAANPLRFTGQEYDAETGLYYNG-ARYY 987

                        650       660       670
                 ....*....|....*....|....*....|....*..
gi 24641507 2596 DPLIGQWMSPDwqrvaeRIITPTRLHLYRFNGNDPIN 2632
Cdd:COG3209  988 DPALGRFLSPD------PIGLAGGLNLYAYVGNNPVN 1018
acid_disulf_rpt NF033662
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ...
 825-851 3.13e-09

acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.


:

Pssm-ID: 411265 [Multi-domain]  Cd Length: 32  Bit Score: 54.44  E-value: 3.13e-09
                          10        20
                  ....*....|....*....|....*..
gi 24641507   825 NCKDNIDNDGDGMTDCSDSECCSHPAC 851
Cdd:NF033662    6 TCSDGIDNDGDGLTDCADPDCAGNPVC 32
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 660-683 2.79e-05

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 43.11  E-value: 2.79e-05
                           10        20
                   ....*....|....*....|....*.
gi 24641507    660 LCSGHGTCVA--GQCYCKAGWQGEDC 683
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
RHS_core super family cl49306
RHS element core protein;
1735-1865 2.82e-04

RHS element core protein;


The actual alignment was detected with superfamily member NF041261:

Pssm-ID: 469161 [Multi-domain]  Cd Length: 1261  Bit Score: 46.92  E-value: 2.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  1735 SSEIYVFNRYGQHVATKDLTSGKTRYSFlysknTSFGRLSTVTDASGnkIQFLRDYSN--VVSSIENTQDHKSEIQINGI 1812
Cdd:NF041261  535 STKQMTWSRYGQLLAFTDCSGYQTRYEY-----DRFGQMTAVHREEG--ISTYRRYDNrgQLTSVKDAQGRETRYEYNAA 607

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 24641507  1813 GIMTKLSEKGRQEIELDYDSnTGLLNSRSSGGETYIYQYDEFGRVTGMILPSG 1865
Cdd:NF041261  608 GDLTAVITPDGNRSETQYDA-WGKAVSTTQGGLTRSMEYDAAGRITTLTNENG 659
C_rich_MXAN6577 super family cl49352
MXAN_6577-like cysteine-rich domain;
661-772 5.73e-04

MXAN_6577-like cysteine-rich domain;


The actual alignment was detected with superfamily member NF041328:

Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 42.82  E-value: 5.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507   661 CSGHGTCVAGQCYCKAGwqGEDCGtidqqvyqclpgcsehgtydletGQCVCERhwTGPD-CSQavCSLDCGRNGVCESG 739
Cdd:NF041328   49 CGAGQTCVAGACGCGPG--TVACG-----------------------GACVDTA--SDPAhCGA--CGAACAPGQVCEGG 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 24641507   740 KCR--CNSGWT--GNLC-----DQL---PCDSRCSEHGQCKNGTC 772
Cdd:NF041328  100 ACReaCSEGLTrcGGACvdlatDPLhcgACGVACDPGESCRGGAC 144
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 563-586 8.63e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.87  E-value: 8.63e-04
                           10        20
                   ....*....|....*....|....*.
gi 24641507    563 DCSGRGSCYL--GKCDCIDGYQGVDC 586
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 629-651 1.87e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.10  E-value: 1.87e-03
                           10        20
                   ....*....|....*....|....*
gi 24641507    629 CSSHGRCI--EGECHCERGWKGPYC 651
Cdd:pfam07974    2 CSGRGTCVnqCGKCVCDSGYQGATC 26
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 789-818 3.58e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 3.58e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 24641507  789 ENGCSRHGQCTLENGEYRCDCIEGWAGRDC 818
Cdd:cd00054    8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
 
Name Accession Description Interval E-value
Tox-GHH pfam15636
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ...
 2889-2966 1.60e-38

GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.


Pssm-ID: 464783  Cd Length: 78  Bit Score: 139.28  E-value: 1.60e-38
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24641507   2889 KEQQRLMHHAKLTAVRKAWHREKEALRSGLTTALEWSQQETDEILKQSYANNYEGEYIHDVNLYPELAEDPYNIKFVK 2966
Cdd:pfam15636    1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 1239-1544 7.35e-35

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 137.66  E-value: 7.35e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1239 NGVAKDAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTILQL----------SATQVSYQYYLAVSPAdGHLYI 1306
Cdd:cd14953   14 GGGGTAARFNSPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTgtagfadgggAAAQFNTPSGVAVDAA-GNLYV 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1307 SDPERHqilrlvRLEKVkDPSINSDPVVGSGQRcipgdeGNCGDGGpALLARLSHPKGLAIAADRTMYIADGTN--IRAV 1384
Cdd:cd14953   93 ADTGNH------RIRKI-TPDGVVSTLAGTGTA------GFSDDGG-ATAAQFNYPTGVAVDAAGNLYVADTGNhrIRKI 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1385 DPKGVIHTLIGhhghhnhwSPAPCS---GTlmANQAQLQWPTGLALSPlDGSLhFIDDRL---VLRLTSDMKIRVVAGTp 1458
Cdd:cd14953  159 TPDGVVTTVAG--------TGGAGYagdGP--ATAAQFNNPTGVAVDA-AGNL-YVADRGnhrIRKITPDGVVTTVAGT- 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1459 lhcsnGGQDGRVNKTGADNVLGTVLAMAFSPFGNLYIADSDSRRvnsIRVVDTAGNMRYFAGKQEGTgsqtcdcaigGGS 1538
Cdd:cd14953  226 -----GTAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGNHR---IRKITPAGVVTTVAGGGAGF----------SGD 287


                 ....*.
gi 24641507 1539 NGSATN 1544
Cdd:cd14953  288 GGPATS 293
RhsA COG3209
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ...
 1983-2632 6.63e-30

Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];


Pssm-ID: 442442 [Multi-domain]  Cd Length: 1103  Bit Score: 130.65  E-value: 6.63e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1983 YSVYSLVGDVRNPQQTLNREIWVNQSRVIGVEFDQFTNRETFYDARRTPILIVAYDQSGLPKSYYPTNGYPVNITYDRFN 2062
Cdd:COG3209  375 GGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTAGGTATGTGTGGGGTTAGTDATTTTGG 454

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 2063 RVEGWAWGPAELKYSYDRHGLLSEITSQQDGIVSFVYNDWNLVSEIGLASQRkfvlqYDDAGGLRHVVLPSGTRHSFSMQ 2142
Cdd:COG3209  455 AGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTL-----GGTTTTTAGARGLVVTTGTTLTL 529

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 2143 TSIGFIRCTYTPPGSTRAYLQHYSHAGALLQTILPGDGARIVYRYNAAGQLTEVVHGDGRSEFQYNEATGMPSTVSHTER 2222
Cdd:COG3209  530 GTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTTTTSTAGTTTTT 609

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 2223 ELEY-RWDFEYAAGLLAEERIDYVAKTGLSNAKFSYEYDSQLRVVALQGRIGGQSLPTQAFAYDPRTGRPSLIGQFRFSQ 2301
Cdd:COG3209  610 TSGYtRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGTGTGVTAGLTTLATGGTTVGGGTGT 689

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 2302 PAQNQTQLHDGTASFTRTVDGRFQTQRMALAIHRLEVFRMEFSYGVHGRISQTRTYTRNMAVNSYTNVKNYTWDCDGQLV 2381
Cdd:COG3209  690 TSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTTAGALTYTYDALGRLT 769

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 2382 GVEAQEP-------WGFRYDDNGNLLSLTY-RGNTIPMEYNAQDRIVK-----------FGEGQYKYDARGLVAQ----- 2437
Cdd:COG3209  770 SETTPGGvtqgtytTRYTYDALGRLTSVTYpDGETVTYTYDALGRLTSvitvgsgggtdLQDRTYTYDAAGNITSitdal 849

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 2438 --NAREERFHYNTQGLLVRASKRGRfDVRYYYDHLKRLTTRKDnfGNVTQFFYTNQQRPYEVSQiyspRDGKLMSLTYDD 2515
Cdd:COG3209  850 raGTLTQTYTYDALGRLTSATDPGT-TESYTYDANGNLTSRTD--GGTTTYTYDALGRLVSVTK----PDGTTTTYTYDA 922

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 2516 VGHliyaqvyrhkyyvaTDQSGTPLMLFNQYGEGIREIMRSPFGHIVYDSNPYLYLPIDFCGGILDQVTTLVHMGdGRVY 2595
Cdd:COG3209  923 LGH--------------TDHLGSVRALTDASGQVVWRYDYDPFGNLLAETSGAAANPLRFTGQEYDAETGLYYNG-ARYY 987

                        650       660       670
                 ....*....|....*....|....*....|....*..
gi 24641507 2596 DPLIGQWMSPDwqrvaeRIITPTRLHLYRFNGNDPIN 2632
Cdd:COG3209  988 DPALGRFLSPD------PIGLAGGLNLYAYVGNNPVN 1018
RHS_core NF041261
RHS element core protein;
2067-2519 2.33e-14

RHS element core protein;


Pssm-ID: 469161 [Multi-domain]  Cd Length: 1261  Bit Score: 80.05  E-value: 2.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  2067 WAWGPA-ELKYSYDRHGllseitSQqdgIVSFVYNDWNLVSEIG--LASQRKFVLQYDDAGGLRHVVLPSGTRHSFSMQT 2143
Cdd:NF041261  322 YTYTEAgELLAVYDRSN------TQ---VRAFTYDAQHPGRMVAhrYAGRPEMCYRYDDTGRVTEQLNPAGLSYRYQYEQ 392

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  2144 SigfiRCTYTPPGSTRAYLqhYSHAGALLQTILP---GDGARIVYRYNAAGQLTEVVHGDGR-SEFQYNEATGMPSTVSH 2219
Cdd:NF041261  393 D----RITITDSLNRREVL--HTEGEGGLKRVVKkehADGSVTRSGYDAAGRLTAQTDAAGRrTEYSLNVVSGDITDITT 466

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  2220 TE-RELEYRWDfeyaagllaeERIDYVAKTGLSNAKFSYEYDSQLRVVALQGRIGgqslPTQAFAYD-PRTGRPSLIG-- 2295
Cdd:NF041261  467 PDgRETKFYYN----------DGNQLTSVTSPDGLESRREYDEPGRLVSETSRSG----ETTRYRYDdPHSELPATTTda 532

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  2296 -----QFRFSQPAQnQTQLHDGTASFTRTVDGRFQTQrmaLAIHRLEVFRMEFSYGVHGRISQTRtytrnmavNSYTNVK 2370
Cdd:NF041261  533 tgstkQMTWSRYGQ-LLAFTDCSGYQTRYEYDRFGQM---TAVHREEGISTYRRYDNRGQLTSVK--------DAQGRET 600

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  2371 NYTWDCDGQLVGVEAqePWGFR----YDDNGNLLSLTYRGNTIPMEYNAQDRIVKF-----GEGQYKYDARGLVAQ---- 2437
Cdd:NF041261  601 RYEYNAAGDLTAVIT--PDGNRsetqYDAWGKAVSTTQGGLTRSMEYDAAGRITTLtnengSHSTFLYDALDRLVQqrgf 678

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  2438 NAREERFHYNTQGLLVRASKRGrFDVRYYYDHLKRLTTRKDNFGNVTQFFYTNQQRPYEVSQIyspRDGKLMSL--TYDD 2515
Cdd:NF041261  679 DGRTQRYHYDLTGKLTQSEDEG-LVTLWHYDESDRITHRTVNGEPAEQWQYDEHGWLTDISHL---SEGHRVAVhyGYDD 754


                  ....
gi 24641507  2516 VGHL 2519
Cdd:NF041261  755 KGRL 758
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1244-1519 1.02e-11

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 68.12  E-value: 1.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1244 DAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTILQLSATQvSYQYYLAVSPaDGHLYISDPERHQILRLvrle 1321
Cdd:COG4257   55 LGGGSGPHGIAVDPDGNLWFTDNgnNRIGRIDPKTGEITTFALPGGG-SNPHGIAFDP-DGNLWFTDQGGNRIGRL---- 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1322 kvkdpsinsDPVVGSgqrcIPGDEGNCGDGGPAllarlshpkGLAIAADRTMYIAD-GTN-IRAVDPK-GVIHTLighhg 1398
Cdd:COG4257  129 ---------DPATGE----VTEFPLPTGGAGPY---------GIAVDPDGNLWVTDfGANaIGRIDPDtGTLTEY----- 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1399 hhnhwspapcsgtlmANQAQLQWPTGLALSPlDGSLHFIDdrlvlrltsdmkirvvagtplhcSNGGQDGRVN-KTGADN 1477
Cdd:COG4257  182 ---------------ALPTPGAGPRGLAVDP-DGNLWVAD-----------------------TGSGRIGRFDpKTGTVT 222

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 24641507 1478 VLGTVL------AMAFSPFGNLYIADSDSrrvNSIRVVDTAGNMRYFA 1519
Cdd:COG4257  223 EYPLPGggarpyGVAVDGDGRVWFAESGA---NRIVRFDPDTELTEYV 267
RHS_core NF041261
RHS element core protein;
1840-2477 1.20e-11

RHS element core protein;


Pssm-ID: 469161 [Multi-domain]  Cd Length: 1261  Bit Score: 71.19  E-value: 1.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  1840 RSSGGETYIYQYDEFGRVTGMILPSGeiVRITSQLADSQgLTVyvhasVESLFSRERIAGEANellvlGGVRSTFLKRgq 1919
Cdd:NF041261  358 RYAGRPEMCYRYDDTGRVTEQLNPAG--LSYRYQYEQDR-ITI-----TDSLNRREVLHTEGE-----GGLKRVVKKE-- 422

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  1920 aHADAELKANntlvihgdngvvvEASAVARhplLEAalpveaemlamwshQSVTMGEGLTNSMYSVYSLVGDVRNPQQTL 1999
Cdd:NF041261  423 -HADGSVTRS-------------GYDAAGR---LTA--------------QTDAAGRRTEYSLNVVSGDITDITTPDGRE 471

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  2000 NREIWVNQSRVIGV----------EFDQfTNRETFYDARRTPILIVAYD--QSGLPKSYYPTNGYPVNITYDRFNRVEGW 2067
Cdd:NF041261  472 TKFYYNDGNQLTSVtspdglesrrEYDE-PGRLVSETSRSGETTRYRYDdpHSELPATTTDATGSTKQMTWSRYGQLLAF 550

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  2068 A-WGPAELKYSYDRHGLLSEItSQQDGIVSF-VYNDWNLVSEIGLASQRKFVLQYDDAGGLRHVVLPSGTRhSFSMQTSI 2145
Cdd:NF041261  551 TdCSGYQTRYEYDRFGQMTAV-HREEGISTYrRYDNRGQLTSVKDAQGRETRYEYNAAGDLTAVITPDGNR-SETQYDAW 628

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  2146 GFIRCTyTPPGSTRAylQHYSHAGALLqTILPGDGARIVYRYNAAGQLTEVVHGDGRSEFQYNEATGmpsTVSHTERE-L 2224
Cdd:NF041261  629 GKAVST-TQGGLTRS--MEYDAAGRIT-TLTNENGSHSTFLYDALDRLVQQRGFDGRTQRYHYDLTG---KLTQSEDEgL 701

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  2225 EYRWDFEyaagllAEERIDYVAKTGLSNAKFSYE---------YDSQLRVVAL------QGRIGGQSLPTQafayDPRTG 2289
Cdd:NF041261  702 VTLWHYD------ESDRITHRTVNGEPAEQWQYDehgwltdisHLSEGHRVAVhygyddKGRLTGERQTVE----NPETG 771

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  2290 RpsLIGQFR----FSQPAQNQTQLHDGTASFTRTVDGRFQTQRMALA-----------IHRlEVFRMEFSYGVHGRISQT 2354
Cdd:NF041261  772 E--LLWQHEtghaYNEQGLANRVTPDSLPPVEWLTYGSGYLAGMKLGgtplveytrdrLHR-ETVRSFGGAGSNAAYELT 848

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  2355 RTYT-----RNMAVNSYTNVKNYTWDCDGQLVGVEA-QEPWGFRYDDNGNLLS-------LTYR--------GNTIP--- 2410
Cdd:NF041261  849 TAYTpagqlQSQHLNSLVYDRDYTWNDNGDLVRISGpRQTREYGYSATGRLTGvhttaanLDIRipyatdpaGNRLPdpe 928

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  2411 ------MEYNAQDRIVKFGEGQYKYDARGLVAQ-------------NAREERFHYNTQGLLVRASK----RGRFDVRYYY 2467
Cdd:NF041261  929 lhpdstLTAWPDNRIAEDAHYVYRYDEYGRLTEktdripegvirtdDERTHHYHYDSQHRLVFYTRiqhgEPLVESRYLY 1008

                         730
                  ....*....|
gi 24641507  2468 DHLKRLTTRK 2477
Cdd:NF041261 1009 DPLGRRMAKR 1018
acid_disulf_rpt NF033662
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ...
 825-851 3.13e-09

acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.


Pssm-ID: 411265 [Multi-domain]  Cd Length: 32  Bit Score: 54.44  E-value: 3.13e-09
                          10        20
                  ....*....|....*....|....*..
gi 24641507   825 NCKDNIDNDGDGMTDCSDSECCSHPAC 851
Cdd:NF033662    6 TCSDGIDNDGDGLTDCADPDCAGNPVC 32
Rhs_assc_core TIGR03696
RHS repeat-associated core domain; This model represents a conserved unique core sequence ...
 2556-2632 3.16e-08

RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.


Pssm-ID: 274730 [Multi-domain]  Cd Length: 77  Bit Score: 52.89  E-value: 3.16e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24641507   2556 SPFGHiVYDSNPYLYLPIDFCGGILDQVTTLVHMGdGRVYDPLIGQWMSPDwqrvaeRIITPTRLHLYRFNGNDPIN 2632
Cdd:TIGR03696    2 DPYGE-VLSESGAAPNPLRFTGQYYDAETGLYYNG-ARYYDPELGRFLSPD------PIGLGGGLNLYAYVGNNPVN 70
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 660-683 2.79e-05

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 43.11  E-value: 2.79e-05
                           10        20
                   ....*....|....*....|....*.
gi 24641507    660 LCSGHGTCVA--GQCYCKAGWQGEDC 683
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
RHS_core NF041261
RHS element core protein;
1735-1865 2.82e-04

RHS element core protein;


Pssm-ID: 469161 [Multi-domain]  Cd Length: 1261  Bit Score: 46.92  E-value: 2.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  1735 SSEIYVFNRYGQHVATKDLTSGKTRYSFlysknTSFGRLSTVTDASGnkIQFLRDYSN--VVSSIENTQDHKSEIQINGI 1812
Cdd:NF041261  535 STKQMTWSRYGQLLAFTDCSGYQTRYEY-----DRFGQMTAVHREEG--ISTYRRYDNrgQLTSVKDAQGRETRYEYNAA 607

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 24641507  1813 GIMTKLSEKGRQEIELDYDSnTGLLNSRSSGGETYIYQYDEFGRVTGMILPSG 1865
Cdd:NF041261  608 GDLTAVITPDGNRSETQYDA-WGKAVSTTQGGLTRSMEYDAAGRITTLTNENG 659
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
 1286-1387 3.98e-04

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 46.38  E-value: 3.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  1286 ATQVSYQYYLAV-SPADGHLYISDPERHQIlrlvrleKVKDPSINS-DPVVGSGQRCIpgdegncgDGGPALLARLSHPK 1363
Cdd:PLN02919  798 GSEVLLQHPLGVlCAKDGQIYVADSYNHKI-------KKLDPATKRvTTLAGTGKAGF--------KDGKALKAQLSEPA 862

                          90       100
                  ....*....|....*....|....*.
gi 24641507  1364 GLAIAADRTMYIADGTN--IRAVDPK 1387
Cdd:PLN02919  863 GLALGENGRLFVADTNNslIRYLDLN 888
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
661-772 5.73e-04

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 42.82  E-value: 5.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507   661 CSGHGTCVAGQCYCKAGwqGEDCGtidqqvyqclpgcsehgtydletGQCVCERhwTGPD-CSQavCSLDCGRNGVCESG 739
Cdd:NF041328   49 CGAGQTCVAGACGCGPG--TVACG-----------------------GACVDTA--SDPAhCGA--CGAACAPGQVCEGG 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 24641507   740 KCR--CNSGWT--GNLC-----DQL---PCDSRCSEHGQCKNGTC 772
Cdd:NF041328  100 ACReaCSEGLTrcGGACvdlatDPLhcgACGVACDPGESCRGGAC 144
DSL pfam01414
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ...
 743-786 7.13e-04

Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.


Pssm-ID: 460202  Cd Length: 46  Bit Score: 39.53  E-value: 7.13e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 24641507    743 CNSGWTGNLCDQLpCDSR--------CSEHGQCkngtcVCSQGWNGRHCTLP 786
Cdd:pfam01414    1 CDENYYGSTCSKF-CRPRddkfghytCDANGNK-----VCLPGWTGPYCDKP 46
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 563-586 8.63e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.87  E-value: 8.63e-04
                           10        20
                   ....*....|....*....|....*.
gi 24641507    563 DCSGRGSCYL--GKCDCIDGYQGVDC 586
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 629-651 1.87e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.10  E-value: 1.87e-03
                           10        20
                   ....*....|....*....|....*
gi 24641507    629 CSSHGRCI--EGECHCERGWKGPYC 651
Cdd:pfam07974    2 CSGRGTCVnqCGKCVCDSGYQGATC 26
RHS_repeat pfam05593
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ...
 1830-1866 1.89e-03

RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.


Pssm-ID: 461685 [Multi-domain]  Cd Length: 37  Bit Score: 37.96  E-value: 1.89e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 24641507   1830 YDSNTGLLNSRSSGGETYIYQYDEFGRVTGMILPSGE 1866
Cdd:pfam05593    1 YDAAGRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDGT 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 789-818 3.58e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 3.58e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 24641507  789 ENGCSRHGQCTLENGEYRCDCIEGWAGRDC 818
Cdd:cd00054    8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 757-784 7.87e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 7.87e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 24641507  757 CDSR--CSEHGQCKNG----TCVCSQGWNGRHCT 784
Cdd:cd00054    5 CASGnpCQNGGTCVNTvgsyRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
Tox-GHH pfam15636
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ...
 2889-2966 1.60e-38

GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.


Pssm-ID: 464783  Cd Length: 78  Bit Score: 139.28  E-value: 1.60e-38
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24641507   2889 KEQQRLMHHAKLTAVRKAWHREKEALRSGLTTALEWSQQETDEILKQSYANNYEGEYIHDVNLYPELAEDPYNIKFVK 2966
Cdd:pfam15636    1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 1239-1544 7.35e-35

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 137.66  E-value: 7.35e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1239 NGVAKDAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTILQL----------SATQVSYQYYLAVSPAdGHLYI 1306
Cdd:cd14953   14 GGGGTAARFNSPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTgtagfadgggAAAQFNTPSGVAVDAA-GNLYV 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1307 SDPERHqilrlvRLEKVkDPSINSDPVVGSGQRcipgdeGNCGDGGpALLARLSHPKGLAIAADRTMYIADGTN--IRAV 1384
Cdd:cd14953   93 ADTGNH------RIRKI-TPDGVVSTLAGTGTA------GFSDDGG-ATAAQFNYPTGVAVDAAGNLYVADTGNhrIRKI 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1385 DPKGVIHTLIGhhghhnhwSPAPCS---GTlmANQAQLQWPTGLALSPlDGSLhFIDDRL---VLRLTSDMKIRVVAGTp 1458
Cdd:cd14953  159 TPDGVVTTVAG--------TGGAGYagdGP--ATAAQFNNPTGVAVDA-AGNL-YVADRGnhrIRKITPDGVVTTVAGT- 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1459 lhcsnGGQDGRVNKTGADNVLGTVLAMAFSPFGNLYIADSDSRRvnsIRVVDTAGNMRYFAGKQEGTgsqtcdcaigGGS 1538
Cdd:cd14953  226 -----GTAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGNHR---IRKITPAGVVTTVAGGGAGF----------SGD 287


                 ....*.
gi 24641507 1539 NGSATN 1544
Cdd:cd14953  288 GGPATS 293
RhsA COG3209
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ...
 1983-2632 6.63e-30

Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];


Pssm-ID: 442442 [Multi-domain]  Cd Length: 1103  Bit Score: 130.65  E-value: 6.63e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1983 YSVYSLVGDVRNPQQTLNREIWVNQSRVIGVEFDQFTNRETFYDARRTPILIVAYDQSGLPKSYYPTNGYPVNITYDRFN 2062
Cdd:COG3209  375 GGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTAGGTATGTGTGGGGTTAGTDATTTTGG 454

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 2063 RVEGWAWGPAELKYSYDRHGLLSEITSQQDGIVSFVYNDWNLVSEIGLASQRkfvlqYDDAGGLRHVVLPSGTRHSFSMQ 2142
Cdd:COG3209  455 AGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTL-----GGTTTTTAGARGLVVTTGTTLTL 529

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 2143 TSIGFIRCTYTPPGSTRAYLQHYSHAGALLQTILPGDGARIVYRYNAAGQLTEVVHGDGRSEFQYNEATGMPSTVSHTER 2222
Cdd:COG3209  530 GTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTTTTSTAGTTTTT 609

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 2223 ELEY-RWDFEYAAGLLAEERIDYVAKTGLSNAKFSYEYDSQLRVVALQGRIGGQSLPTQAFAYDPRTGRPSLIGQFRFSQ 2301
Cdd:COG3209  610 TSGYtRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGTGTGVTAGLTTLATGGTTVGGGTGT 689

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 2302 PAQNQTQLHDGTASFTRTVDGRFQTQRMALAIHRLEVFRMEFSYGVHGRISQTRTYTRNMAVNSYTNVKNYTWDCDGQLV 2381
Cdd:COG3209  690 TSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTTAGALTYTYDALGRLT 769

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 2382 GVEAQEP-------WGFRYDDNGNLLSLTY-RGNTIPMEYNAQDRIVK-----------FGEGQYKYDARGLVAQ----- 2437
Cdd:COG3209  770 SETTPGGvtqgtytTRYTYDALGRLTSVTYpDGETVTYTYDALGRLTSvitvgsgggtdLQDRTYTYDAAGNITSitdal 849

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 2438 --NAREERFHYNTQGLLVRASKRGRfDVRYYYDHLKRLTTRKDnfGNVTQFFYTNQQRPYEVSQiyspRDGKLMSLTYDD 2515
Cdd:COG3209  850 raGTLTQTYTYDALGRLTSATDPGT-TESYTYDANGNLTSRTD--GGTTTYTYDALGRLVSVTK----PDGTTTTYTYDA 922

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 2516 VGHliyaqvyrhkyyvaTDQSGTPLMLFNQYGEGIREIMRSPFGHIVYDSNPYLYLPIDFCGGILDQVTTLVHMGdGRVY 2595
Cdd:COG3209  923 LGH--------------TDHLGSVRALTDASGQVVWRYDYDPFGNLLAETSGAAANPLRFTGQEYDAETGLYYNG-ARYY 987

                        650       660       670
                 ....*....|....*....|....*....|....*..
gi 24641507 2596 DPLIGQWMSPDwqrvaeRIITPTRLHLYRFNGNDPIN 2632
Cdd:COG3209  988 DPALGRFLSPD------PIGLAGGLNLYAYVGNNPVN 1018
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 1237-1506 9.03e-27

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 113.78  E-value: 9.03e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1237 YCNGVAKDAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTIL-----------QLSATQVSYQYYLAVSPAdGH 1303
Cdd:cd14953   66 FADGGGAAAQFNTPSGVAVDAAGNLYVADTgnHRIRKITPDGVVSTLAgtgtagfsddgGATAAQFNYPTGVAVDAA-GN 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1304 LYISDPERHQILRlvrlekvkdpsINSDPVV----GSGqrcipgdEGNCGDGGPALLARLSHPKGLAIAADRTMYIADGT 1379
Cdd:cd14953  145 LYVADTGNHRIRK-----------ITPDGVVttvaGTG-------GAGYAGDGPATAAQFNNPTGVAVDAAGNLYVADRG 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1380 N--IRAVDPKGVIHTLIGHHGhhnhwspAPCSGTLMANQAQLQWPTGLALSPlDGSLhFIDDRL---VLRLTSDMKIRVV 1454
Cdd:cd14953  207 NhrIRKITPDGVVTTVAGTGT-------AGFSGDGGATAAQLNNPTGVAVDA-AGNL-YVADSGnhrIRKITPAGVVTTV 277

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 24641507 1455 AGTPlhCSNGGQDGRVNKTGADNVLGtvlaMAFSPFGNLYIADSDSRRVNSI 1506
Cdd:cd14953  278 AGGG--AGFSGDGGPATSAQFNNPTG----VAVDAAGNLYVADTGNNRIRKI 323
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1244-1503 4.64e-19

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 89.69  E-value: 4.64e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1244 DAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTILQLSATQVSYQYY---LAVSPaDGHLYISDPERHQILRLv 1318
Cdd:cd05819   51 DGQFNEPAGVAVDSDGNLYVADTgnHRIQKFDPDGNFLASFGGSGDGDGEFNGprgIAVDS-SGNIYVADTGNHRIQKF- 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1319 rlekvkDPSinsdpvvGSGQRCIPGDEGNCGDggpallarLSHPKGLAIAADRTMYIADGTN--IRAVDPKGVIHTLIGH 1396
Cdd:cd05819  129 ------DPD-------GEFLTTFGSGGSGPGQ--------FNGPTGVAVDSDGNIYVADTGNhrIQVFDPDGNFLTTFGS 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1397 HGHHNhwspapcsgtlmanqAQLQWPTGLALSPlDGSLHFID--DRLVLRLTSDMKIRVVAGTPLhcsnggqdgrvnktG 1474
Cdd:cd05819  188 TGTGP---------------GQFNYPTGIAVDS-DGNIYVADsgNNRVQVFDPDGAGFGGNGNFL--------------G 237

                        250       260
                 ....*....|....*....|....*....
gi 24641507 1475 ADNVLGTVLAMAFSPFGNLYIADSDSRRV 1503
Cdd:cd05819  238 SDGQFNRPSGLAVDSDGNLYVADTGNNRI 266
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 1349-1544 1.67e-18

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 89.51  E-value: 1.67e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1349 GDGGPALLARLSHPKGLAIAADRTMYIADGTN--IRAVDPKGVIHTLI--GHHGHHNHWSPApcsgtlmanqAQLQWPTG 1424
Cdd:cd14953   12 FSGGGGTAARFNSPSGVAVDAAGNLYVADRGNhrIRKITPDGVVTTVAgtGTAGFADGGGAA----------AQFNTPSG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1425 LALSPlDGSLhFIDDRL---VLRLTSDMKIRVVAGTplhCSNGGQDGrvnkTGADN-VLGTVLAMAFSPFGNLYIADsds 1500
Cdd:cd14953   82 VAVDA-AGNL-YVADTGnhrIRKITPDGVVSTLAGT---GTAGFSDD----GGATAaQFNYPTGVAVDAAGNLYVAD--- 149

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 24641507 1501 RRVNSIRVVDTAGNMRYFAgkqeGTGSQtcdcaiGGGSNGSATN 1544
Cdd:cd14953  150 TGNHRIRKITPDGVVTTVA----GTGGA------GYAGDGPATA 183
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1243-1528 2.54e-16

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 81.60  E-value: 2.54e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1243 KDAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTILQLSAT---QVSYQYYLAVSPaDGHLYISDPERHQILRL 1317
Cdd:cd05819    3 GPGELNNPQGIAVDSSGNIYVADTgnNRIQVFDPDGNFITSFGSFGSgdgQFNEPAGVAVDS-DGNLYVADTGNHRIQKF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1318 vrlekvkdpSINSDPVVGSGqrcIPGDegncGDGGpallarLSHPKGLAIAADRTMYIADGTN--IRAVDPKGVIHTLIG 1395
Cdd:cd05819   82 ---------DPDGNFLASFG---GSGD----GDGE------FNGPRGIAVDSSGNIYVADTGNhrIQKFDPDGEFLTTFG 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1396 HHGhhnhwspapcsgtlmANQAQLQWPTGLALSPlDGSLhFIDDRLVLRltsdmkIRVVAgtplhcSNGGQDGRVNKTGA 1475
Cdd:cd05819  140 SGG---------------SGPGQFNGPTGVAVDS-DGNI-YVADTGNHR------IQVFD------PDGNFLTTFGSTGT 190

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 24641507 1476 -DNVLGTVLAMAFSPFGNLYIADSDSRRvnsIRVVDTAGNMRYFAGKQEGTGSQ 1528
Cdd:cd05819  191 gPGQFNYPTGIAVDSDGNIYVADSGNNR---VQVFDPDGAGFGGNGNFLGSDGQ 241
RHS_core NF041261
RHS element core protein;
2067-2519 2.33e-14

RHS element core protein;


Pssm-ID: 469161 [Multi-domain]  Cd Length: 1261  Bit Score: 80.05  E-value: 2.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  2067 WAWGPA-ELKYSYDRHGllseitSQqdgIVSFVYNDWNLVSEIG--LASQRKFVLQYDDAGGLRHVVLPSGTRHSFSMQT 2143
Cdd:NF041261  322 YTYTEAgELLAVYDRSN------TQ---VRAFTYDAQHPGRMVAhrYAGRPEMCYRYDDTGRVTEQLNPAGLSYRYQYEQ 392

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  2144 SigfiRCTYTPPGSTRAYLqhYSHAGALLQTILP---GDGARIVYRYNAAGQLTEVVHGDGR-SEFQYNEATGMPSTVSH 2219
Cdd:NF041261  393 D----RITITDSLNRREVL--HTEGEGGLKRVVKkehADGSVTRSGYDAAGRLTAQTDAAGRrTEYSLNVVSGDITDITT 466

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  2220 TE-RELEYRWDfeyaagllaeERIDYVAKTGLSNAKFSYEYDSQLRVVALQGRIGgqslPTQAFAYD-PRTGRPSLIG-- 2295
Cdd:NF041261  467 PDgRETKFYYN----------DGNQLTSVTSPDGLESRREYDEPGRLVSETSRSG----ETTRYRYDdPHSELPATTTda 532

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  2296 -----QFRFSQPAQnQTQLHDGTASFTRTVDGRFQTQrmaLAIHRLEVFRMEFSYGVHGRISQTRtytrnmavNSYTNVK 2370
Cdd:NF041261  533 tgstkQMTWSRYGQ-LLAFTDCSGYQTRYEYDRFGQM---TAVHREEGISTYRRYDNRGQLTSVK--------DAQGRET 600

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  2371 NYTWDCDGQLVGVEAqePWGFR----YDDNGNLLSLTYRGNTIPMEYNAQDRIVKF-----GEGQYKYDARGLVAQ---- 2437
Cdd:NF041261  601 RYEYNAAGDLTAVIT--PDGNRsetqYDAWGKAVSTTQGGLTRSMEYDAAGRITTLtnengSHSTFLYDALDRLVQqrgf 678

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  2438 NAREERFHYNTQGLLVRASKRGrFDVRYYYDHLKRLTTRKDNFGNVTQFFYTNQQRPYEVSQIyspRDGKLMSL--TYDD 2515
Cdd:NF041261  679 DGRTQRYHYDLTGKLTQSEDEG-LVTLWHYDESDRITHRTVNGEPAEQWQYDEHGWLTDISHL---SEGHRVAVhyGYDD 754


                  ....
gi 24641507  2516 VGHL 2519
Cdd:NF041261  755 KGRL 758
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1243-1434 8.40e-13

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 71.20  E-value: 8.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1243 KDAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTIL---QLSATQVSYQYYLAVSPaDGHLYISDPERHQILRL 1317
Cdd:cd05819   97 GDGEFNGPRGIAVDSSGNIYVADTgnHRIQKFDPDGEFLTTFgsgGSGPGQFNGPTGVAVDS-DGNIYVADTGNHRIQVF 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1318 vrlekvkDPSINSDPVVGSGqrcipgdegncGDGGpallARLSHPKGLAIAADRTMYIADGTN--IRAVDPKGVIHTlig 1395
Cdd:cd05819  176 -------DPDGNFLTTFGST-----------GTGP----GQFNYPTGIAVDSDGNIYVADSGNnrVQVFDPDGAGFG--- 230

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 24641507 1396 hhghhnhwspapCSGTLMANQAQLQWPTGLALSPlDGSL 1434
Cdd:cd05819  231 ------------GNGNFLGSDGQFNRPSGLAVDS-DGNL 256
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1244-1519 1.02e-11

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 68.12  E-value: 1.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1244 DAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTILQLSATQvSYQYYLAVSPaDGHLYISDPERHQILRLvrle 1321
Cdd:COG4257   55 LGGGSGPHGIAVDPDGNLWFTDNgnNRIGRIDPKTGEITTFALPGGG-SNPHGIAFDP-DGNLWFTDQGGNRIGRL---- 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1322 kvkdpsinsDPVVGSgqrcIPGDEGNCGDGGPAllarlshpkGLAIAADRTMYIAD-GTN-IRAVDPK-GVIHTLighhg 1398
Cdd:COG4257  129 ---------DPATGE----VTEFPLPTGGAGPY---------GIAVDPDGNLWVTDfGANaIGRIDPDtGTLTEY----- 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1399 hhnhwspapcsgtlmANQAQLQWPTGLALSPlDGSLHFIDdrlvlrltsdmkirvvagtplhcSNGGQDGRVN-KTGADN 1477
Cdd:COG4257  182 ---------------ALPTPGAGPRGLAVDP-DGNLWVAD-----------------------TGSGRIGRFDpKTGTVT 222

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 24641507 1478 VLGTVL------AMAFSPFGNLYIADSDSrrvNSIRVVDTAGNMRYFA 1519
Cdd:COG4257  223 EYPLPGggarpyGVAVDGDGRVWFAESGA---NRIVRFDPDTELTEYV 267
RHS_core NF041261
RHS element core protein;
1840-2477 1.20e-11

RHS element core protein;


Pssm-ID: 469161 [Multi-domain]  Cd Length: 1261  Bit Score: 71.19  E-value: 1.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  1840 RSSGGETYIYQYDEFGRVTGMILPSGeiVRITSQLADSQgLTVyvhasVESLFSRERIAGEANellvlGGVRSTFLKRgq 1919
Cdd:NF041261  358 RYAGRPEMCYRYDDTGRVTEQLNPAG--LSYRYQYEQDR-ITI-----TDSLNRREVLHTEGE-----GGLKRVVKKE-- 422

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  1920 aHADAELKANntlvihgdngvvvEASAVARhplLEAalpveaemlamwshQSVTMGEGLTNSMYSVYSLVGDVRNPQQTL 1999
Cdd:NF041261  423 -HADGSVTRS-------------GYDAAGR---LTA--------------QTDAAGRRTEYSLNVVSGDITDITTPDGRE 471

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  2000 NREIWVNQSRVIGV----------EFDQfTNRETFYDARRTPILIVAYD--QSGLPKSYYPTNGYPVNITYDRFNRVEGW 2067
Cdd:NF041261  472 TKFYYNDGNQLTSVtspdglesrrEYDE-PGRLVSETSRSGETTRYRYDdpHSELPATTTDATGSTKQMTWSRYGQLLAF 550

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  2068 A-WGPAELKYSYDRHGLLSEItSQQDGIVSF-VYNDWNLVSEIGLASQRKFVLQYDDAGGLRHVVLPSGTRhSFSMQTSI 2145
Cdd:NF041261  551 TdCSGYQTRYEYDRFGQMTAV-HREEGISTYrRYDNRGQLTSVKDAQGRETRYEYNAAGDLTAVITPDGNR-SETQYDAW 628

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  2146 GFIRCTyTPPGSTRAylQHYSHAGALLqTILPGDGARIVYRYNAAGQLTEVVHGDGRSEFQYNEATGmpsTVSHTERE-L 2224
Cdd:NF041261  629 GKAVST-TQGGLTRS--MEYDAAGRIT-TLTNENGSHSTFLYDALDRLVQQRGFDGRTQRYHYDLTG---KLTQSEDEgL 701

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  2225 EYRWDFEyaagllAEERIDYVAKTGLSNAKFSYE---------YDSQLRVVAL------QGRIGGQSLPTQafayDPRTG 2289
Cdd:NF041261  702 VTLWHYD------ESDRITHRTVNGEPAEQWQYDehgwltdisHLSEGHRVAVhygyddKGRLTGERQTVE----NPETG 771

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  2290 RpsLIGQFR----FSQPAQNQTQLHDGTASFTRTVDGRFQTQRMALA-----------IHRlEVFRMEFSYGVHGRISQT 2354
Cdd:NF041261  772 E--LLWQHEtghaYNEQGLANRVTPDSLPPVEWLTYGSGYLAGMKLGgtplveytrdrLHR-ETVRSFGGAGSNAAYELT 848

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  2355 RTYT-----RNMAVNSYTNVKNYTWDCDGQLVGVEA-QEPWGFRYDDNGNLLS-------LTYR--------GNTIP--- 2410
Cdd:NF041261  849 TAYTpagqlQSQHLNSLVYDRDYTWNDNGDLVRISGpRQTREYGYSATGRLTGvhttaanLDIRipyatdpaGNRLPdpe 928

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  2411 ------MEYNAQDRIVKFGEGQYKYDARGLVAQ-------------NAREERFHYNTQGLLVRASK----RGRFDVRYYY 2467
Cdd:NF041261  929 lhpdstLTAWPDNRIAEDAHYVYRYDEYGRLTEktdripegvirtdDERTHHYHYDSQHRLVFYTRiqhgEPLVESRYLY 1008

                         730
                  ....*....|
gi 24641507  2468 DHLKRLTTRK 2477
Cdd:NF041261 1009 DPLGRRMAKR 1018
acid_disulf_rpt NF033662
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ...
 825-851 3.13e-09

acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.


Pssm-ID: 411265 [Multi-domain]  Cd Length: 32  Bit Score: 54.44  E-value: 3.13e-09
                          10        20
                  ....*....|....*....|....*..
gi 24641507   825 NCKDNIDNDGDGMTDCSDSECCSHPAC 851
Cdd:NF033662    6 TCSDGIDNDGDGLTDCADPDCAGNPVC 32
Rhs_assc_core TIGR03696
RHS repeat-associated core domain; This model represents a conserved unique core sequence ...
 2556-2632 3.16e-08

RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.


Pssm-ID: 274730 [Multi-domain]  Cd Length: 77  Bit Score: 52.89  E-value: 3.16e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24641507   2556 SPFGHiVYDSNPYLYLPIDFCGGILDQVTTLVHMGdGRVYDPLIGQWMSPDwqrvaeRIITPTRLHLYRFNGNDPIN 2632
Cdd:TIGR03696    2 DPYGE-VLSESGAAPNPLRFTGQYYDAETGLYYNG-ARYYDPELGRFLSPD------PIGLGGGLNLYAYVGNNPVN 70
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1240-1398 6.13e-08

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 56.83  E-value: 6.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1240 GVAKDAKLLTPIALATGPDGSLYVGDFNL--VRRITPDGK-VYTI----LQLSATQVsyqyylAVSPADGHLYISDPERH 1312
Cdd:cd14962   49 GNAGPNRFVSPIGVAIDANGNLYVSDAELgkVFVFDRDGKfLRAIgagaLFKRPTGI------AVDPAGKRLYVVDTLAH 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1313 QIlrlvrleKVKDPSinsdpvvGSGQRCIpgdeGNCGDGGpallARLSHPKGLAIAADRTMYIADGTNIR--AVDPKGVI 1390
Cdd:cd14962  123 KV-------KVFDLD-------GRLLFDI----GKRGSGP----GEFNLPTDLAVDRDGNLYVTDTMNFRvqIFDADGKF 180


                 ....*...
gi 24641507 1391 HTLIGHHG 1398
Cdd:cd14962  181 LRSFGERG 188
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1244-1503 8.07e-08

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 56.52  E-value: 8.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1244 DAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTILQLSAT---QVSYQYYLAVSPaDGHLYISDPERHQILRLv 1318
Cdd:cd14956   56 PGQFGRPRGLAVDKDGWLYVADYwgDRIQVFTLTGELQTIGGSSGSgpgQFNAPRGVAVDA-DGNLYVADFGNQRIQKF- 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1319 rlekvkdpsinsDP---VVGS-GQRCIPGDEGNcgdggpallarlsHPKGLAIAADRTMYIADGTN--IRAVDPKGVIHT 1392
Cdd:cd14956  134 ------------DPdgsFLRQwGGTGIEPGSFN-------------YPRGVAVDPDGTLYVADTYNdrIQVFDNDGAFLR 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1393 LIGHHGHHNHWspapcsgtlmanqaqLQWPTGLALSPlDGSLHFID---DRlVLRLTSDMKIRVVAGTPlhcsnGGQDGR 1469
Cdd:cd14956  189 KWGGRGTGPGQ---------------FNYPYGIAIDP-DGNVFVADfgnNR-IQKFTADGTFLTSWGSP-----GTGPGQ 246

                        250       260       270
                 ....*....|....*....|....*....|....
gi 24641507 1470 vnktgadnvLGTVLAMAFSPFGNLYIADSDSRRV 1503
Cdd:cd14956  247 ---------FKNPWGVVVDADGTVYVADSNNNRV 271
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
 1346-1514 2.01e-07

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 55.66  E-value: 2.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1346 GNCG--DGGPALlARLSHPKGLAIAADRTMYIADGTN--IRAVDP-KGVIHTL--IGHHGHHNhwspapcSGTLMANQAQ 1418
Cdd:cd14951    4 GERGlkDGSFAE-ASFNEPQGLALLPGNILYVADTENhaLRKIDLeTGTVTTLagTGEQGRDG-------EGGGPGREQP 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1419 LQwptglalSPLDGSLHFIDDRLVLR----------LTSDMKIRVVAGTplhcsngGQDGRVNKTGADNvlgTVLA---- 1484
Cdd:cd14951   76 LS-------SPWDVAWGPEDDILYIAmagthqiwayDLDTGTCRVFAGS-------GNEGNRNGPYPHE---AWFAqpsg 138

                        170       180       190
                 ....*....|....*....|....*....|
gi 24641507 1485 MAFSPFGNLYIADSDSrrvNSIRVVDTAGN 1514
Cdd:cd14951  139 LSLAGWGELFVADSES---SAIRAVSLKDG 165
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 660-683 2.79e-05

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 43.11  E-value: 2.79e-05
                           10        20
                   ....*....|....*....|....*.
gi 24641507    660 LCSGHGTCVA--GQCYCKAGWQGEDC 683
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1293-1526 5.40e-05

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 47.71  E-value: 5.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1293 YYLAVSPaDGHLYISDPERHQILRLvrlekvkdpsinsDPVVGSGQRcipgdegncgdggpALLARLSHPKGLAIAADRT 1372
Cdd:COG4257   20 RDVAVDP-DGAVWFTDQGGGRIGRL-------------DPATGEFTE--------------YPLGGGSGPHGIAVDPDGN 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1373 MYIADGTN--IRAVDPK-GVIHTLIGhhghhnhwsPAPCSGtlmanqaqlqwPTGLALSPlDGSLHFIDDR--LVLRLT- 1446
Cdd:COG4257   72 LWFTDNGNnrIGRIDPKtGEITTFAL---------PGGGSN-----------PHGIAFDP-DGNLWFTDQGgnRIGRLDp 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1447 SDMKIRVVAGTplhcSNGGQDGrvnktgadnvlgtvlAMAFSPFGNLYIADsdsRRVNSIRVVDTA-GNMRYFAGKQEGT 1525
Cdd:COG4257  131 ATGEVTEFPLP----TGGAGPY---------------GIAVDPDGNLWVTD---FGANAIGRIDPDtGTLTEYALPTPGA 188


                 .
gi 24641507 1526 G 1526
Cdd:COG4257  189 G 189
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
 1240-1322 6.53e-05

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 47.96  E-value: 6.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1240 GVAKDAKLLTPIALATGPDGSLYVGD-FN-LVRRITPD-GKVYTI---LQLSATQVSYQYY----LAVSPaDGHLYISDP 1309
Cdd:cd14951  188 GPGAEALLQHPLGVAALPDGSVYVADtYNhKIKRVDPAtGEVSTLagtGKAGYKDLEAQFSepsgLVVDG-DGRLYVADT 266

                         90
                 ....*....|...
gi 24641507 1310 ERHQIlRLVRLEK 1322
Cdd:cd14951  267 NNHRI-RRLDLPT 278
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
 1295-1434 6.59e-05

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 47.96  E-value: 6.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1295 LAVSPaDGHLYISDPERhQILRLVRLEKVKDPSINSDPVVGSGQrcipgdeGNCGD-GGPALLARLSHPKGLAIAADRTM 1373
Cdd:cd14951  139 LSLAG-WGELFVADSES-SAIRAVSLKDGGVKTLVGGTRVGTGL-------FDFGDrDGPGAEALLQHPLGVAALPDGSV 209

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24641507 1374 YIADGTN--IRAVDPK-GVIHTLIghhghhnhwspapcsGTLMAN----QAQLQWPTGLALSPlDGSL 1434
Cdd:cd14951  210 YVADTYNhkIKRVDPAtGEVSTLA---------------GTGKAGykdlEAQFSEPSGLVVDG-DGRL 261
RHS_core NF041261
RHS element core protein;
1735-1865 2.82e-04

RHS element core protein;


Pssm-ID: 469161 [Multi-domain]  Cd Length: 1261  Bit Score: 46.92  E-value: 2.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  1735 SSEIYVFNRYGQHVATKDLTSGKTRYSFlysknTSFGRLSTVTDASGnkIQFLRDYSN--VVSSIENTQDHKSEIQINGI 1812
Cdd:NF041261  535 STKQMTWSRYGQLLAFTDCSGYQTRYEY-----DRFGQMTAVHREEG--ISTYRRYDNrgQLTSVKDAQGRETRYEYNAA 607

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 24641507  1813 GIMTKLSEKGRQEIELDYDSnTGLLNSRSSGGETYIYQYDEFGRVTGMILPSG 1865
Cdd:NF041261  608 GDLTAVITPDGNRSETQYDA-WGKAVSTTQGGLTRSMEYDAAGRITTLTNENG 659
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 1300-1526 3.48e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 45.27  E-value: 3.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1300 ADGHLYISDPERHQILRLvrlekvkDPSinsdpvvGSGQRCIPGDEGncgdggpallarlsHPKGLAIAADRTMYIAD-G 1378
Cdd:COG3386   17 PDGRLYWVDIPGGRIHRY-------DPD-------GGAVEVFAEPSG--------------RPNGLAFDPDGRLLVADhG 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1379 TNIRAVDPK-GVIHTLIGHHGHhnhwspapcsgtlmanqaQLQWPTGLALSPlDGSL------HFIDDRLVLRLTSDMKI 1451
Cdd:COG3386   69 RGLVRFDPAdGEVTVLADEYGK------------------PLNRPNDGVVDP-DGRLyftdmgEYLPTGALYRVDPDGSL 129

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24641507 1452 RVVAgTPLHCSNGgqdgrvnktgadnvlgtvlaMAFSPFGN-LYIADSDSRRVNSIRVVD--TAGNMRYFAGKQEGTG 1526
Cdd:COG3386  130 RVLA-DGLTFPNG--------------------IAFSPDGRtLYVADTGAGRIYRFDLDAdgTLGNRRVFADLPDGPG 186
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
 1286-1387 3.98e-04

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 46.38  E-value: 3.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507  1286 ATQVSYQYYLAV-SPADGHLYISDPERHQIlrlvrleKVKDPSINS-DPVVGSGQRCIpgdegncgDGGPALLARLSHPK 1363
Cdd:PLN02919  798 GSEVLLQHPLGVlCAKDGQIYVADSYNHKI-------KKLDPATKRvTTLAGTGKAGF--------KDGKALKAQLSEPA 862

                          90       100
                  ....*....|....*....|....*.
gi 24641507  1364 GLAIAADRTMYIADGTN--IRAVDPK 1387
Cdd:PLN02919  863 GLALGENGRLFVADTNNslIRYLDLN 888
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 1253-1394 4.63e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 44.88  E-value: 4.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1253 LATGPDGSLYVGDFNLVR------RITPDGKVYTIlqlsATQVSYQYYLAVSPADGHLYISDPERHQILRLvrlekvkdp 1326
Cdd:COG3386   98 GVVDPDGRLYFTDMGEYLptgalyRVDPDGSLRVL----ADGLTFPNGIAFSPDGRTLYVADTGAGRIYRF--------- 164

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1327 SINSDPVVGSGQRCIPGDEgncGDGGPAllarlshpkGLAIAADRTMYIA--DGTNIRAVDPKGVIHTLI 1394
Cdd:COG3386  165 DLDADGTLGNRRVFADLPD---GPGGPD---------GLAVDADGNLWVAlwGGGGVVRFDPDGELLGRI 222
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1239-1317 5.10e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 44.62  E-value: 5.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1239 NGVAKDAKLLTPIALATGPDGSLYVGDF--NLVRRITPDGKVYTIL---QLSATQVSYQYYLAVSPaDGHLYISDPERHQ 1313
Cdd:cd05819  187 STGTGPGQFNYPTGIAVDSDGNIYVADSgnNRVQVFDPDGAGFGGNgnfLGSDGQFNRPSGLAVDS-DGNLYVADTGNNR 265


                 ....
gi 24641507 1314 ILRL 1317
Cdd:cd05819  266 IQVF 269
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
661-772 5.73e-04

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 42.82  E-value: 5.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507   661 CSGHGTCVAGQCYCKAGwqGEDCGtidqqvyqclpgcsehgtydletGQCVCERhwTGPD-CSQavCSLDCGRNGVCESG 739
Cdd:NF041328   49 CGAGQTCVAGACGCGPG--TVACG-----------------------GACVDTA--SDPAhCGA--CGAACAPGQVCEGG 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 24641507   740 KCR--CNSGWT--GNLC-----DQL---PCDSRCSEHGQCKNGTC 772
Cdd:NF041328  100 ACReaCSEGLTrcGGACvdlatDPLhcgACGVACDPGESCRGGAC 144
DSL pfam01414
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ...
 743-786 7.13e-04

Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.


Pssm-ID: 460202  Cd Length: 46  Bit Score: 39.53  E-value: 7.13e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 24641507    743 CNSGWTGNLCDQLpCDSR--------CSEHGQCkngtcVCSQGWNGRHCTLP 786
Cdd:pfam01414    1 CDENYYGSTCSKF-CRPRddkfghytCDANGNK-----VCLPGWTGPYCDKP 46
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 563-586 8.63e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.87  E-value: 8.63e-04
                           10        20
                   ....*....|....*....|....*.
gi 24641507    563 DCSGRGSCYL--GKCDCIDGYQGVDC 586
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 697-721 1.11e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.48  E-value: 1.11e-03
                           10        20
                   ....*....|....*....|....*
gi 24641507    697 CSEHGTYDLETGQCVCERHWTGPDC 721
Cdd:pfam07974    2 CSGRGTCVNQCGKCVCDSGYQGATC 26
YliI COG2133
Glucose/arabinose dehydrogenase, beta-propeller fold [Carbohydrate transport and metabolism];
1250-1381 1.14e-03

Glucose/arabinose dehydrogenase, beta-propeller fold [Carbohydrate transport and metabolism];


Pssm-ID: 441736 [Multi-domain]  Cd Length: 365  Bit Score: 44.15  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1250 PIALATGPDGSLYVGD-FNLVRRITPDGKVYTILQLSATQVSYQY---YLAVSP---ADGHLYI--SDPERHQiLRLVRL 1320
Cdd:COG2133   39 PWGLAFLPDGRLLVTErAGRIRLLDDDGKLSTPVADLPVFAGGEGgllGVALDPdfaTNGYLYVayTDPGGAG-TRVARF 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24641507 1321 EKVKDPSINSDPVVGSGqrcIPGDEGNcgdggpallarlsHP-KGLAIAADRTMYIA--DGTNI 1381
Cdd:COG2133  118 TLSDGDTLTSEEVILDG---LPAGGGN-------------HNgGRLAFGPDGKLYVSvgDRGNA 165
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 629-651 1.87e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.10  E-value: 1.87e-03
                           10        20
                   ....*....|....*....|....*
gi 24641507    629 CSSHGRCI--EGECHCERGWKGPYC 651
Cdd:pfam07974    2 CSGRGTCVnqCGKCVCDSGYQGATC 26
RHS_repeat pfam05593
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ...
 1830-1866 1.89e-03

RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.


Pssm-ID: 461685 [Multi-domain]  Cd Length: 37  Bit Score: 37.96  E-value: 1.89e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 24641507   1830 YDSNTGLLNSRSSGGETYIYQYDEFGRVTGMILPSGE 1866
Cdd:pfam05593    1 YDAAGRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDGT 37
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 729-752 2.69e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.33  E-value: 2.69e-03
                           10        20
                   ....*....|....*....|....*.
gi 24641507    729 DCGRNGVCES--GKCRCNSGWTGNLC 752
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 761-783 2.72e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.33  E-value: 2.72e-03
                           10        20
                   ....*....|....*....|....*
gi 24641507    761 CSEHGQC--KNGTCVCSQGWNGRHC 783
Cdd:pfam07974    2 CSGRGTCvnQCGKCVCDSGYQGATC 26
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 789-818 3.58e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 3.58e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 24641507  789 ENGCSRHGQCTLENGEYRCDCIEGWAGRDC 818
Cdd:cd00054    8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 560-587 4.72e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 36.89  E-value: 4.72e-03
                           10        20
                   ....*....|....*....|....*...
gi 24641507    560 CPNDCSGRGSCYLGKCDCIDGYQGVDCS 587
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
DSL pfam01414
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ...
 608-653 5.75e-03

Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.


Pssm-ID: 460202  Cd Length: 46  Bit Score: 37.22  E-value: 5.75e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 24641507    608 CEEGWKGAECDIpvgECEVPN-------CSSHGRCIegechCERGWKGPYCDQ 653
Cdd:pfam01414    1 CDENYYGSTCSK---FCRPRDdkfghytCDANGNKV-----CLPGWTGPYCDK 45
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
 1253-1387 6.56e-03

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 41.41  E-value: 6.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1253 LATGPDGSLYVGD--FNLVRRITP-DGKVYTILQLS---------------ATQVSYQYYLAVSPA-DGHLYISDPERHQ 1313
Cdd:cd14951  139 LSLAGWGELFVADseSSAIRAVSLkDGGVKTLVGGTrvgtglfdfgdrdgpGAEALLQHPLGVAALpDGSVYVADTYNHK 218

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24641507 1314 ILRLvrlekvkdpsinsDPVVGSGQRCIPGDEGNCGDggpaLLARLSHPKGLAIAADRTMYIADgTN---IRAVDPK 1387
Cdd:cd14951  219 IKRV-------------DPATGEVSTLAGTGKAGYKD----LEAQFSEPSGLVVDGDGRLYVAD-TNnhrIRRLDLP 277
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 1257-1536 7.26e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 41.03  E-value: 7.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1257 PDGSLYVGDF--NLVRRITPDGKVYTILQLSATQVSYqyyLAVSPaDGHLYISDPERhqilRLVRLEKvkdpsinsdpvv 1334
Cdd:COG3386   17 PDGRLYWVDIpgGRIHRYDPDGGAVEVFAEPSGRPNG---LAFDP-DGRLLVADHGR----GLVRFDP------------ 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1335 gsgqrcipgdegncGDGGPALLA-----RLSHPKGLAIAADRTMYIAD------GTNIRAVDPKGVIHTLIGHhghhnhw 1403
Cdd:COG3386   77 --------------ADGEVTVLAdeygkPLNRPNDGVVDPDGRLYFTDmgeylpTGALYRVDPDGSLRVLADG------- 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641507 1404 spapcsgtlmanqaqLQWPTGLALSPlDGS-LHFID--DRLVLRLTSDMKIRVVAGTPLHcsnggqDGRVNKTGADNvlg 1480
Cdd:COG3386  136 ---------------LTFPNGIAFSP-DGRtLYVADtgAGRIYRFDLDADGTLGNRRVFA------DLPDGPGGPDG--- 190

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 24641507 1481 tvlaMAFSPFGNLYIADSDSRRVnsiRVVDTAGNMRyfaGKQEGTGSQTCDCAIGG 1536
Cdd:COG3386  191 ----LAVDADGNLWVALWGGGGV---VRFDPDGELL---GRIELPERRPTNVAFGG 236
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 757-784 7.87e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 7.87e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 24641507  757 CDSR--CSEHGQCKNG----TCVCSQGWNGRHCT 784
Cdd:cd00054    5 CASGnpCQNGGTCVNTvgsyRCSCPPGYTGRNCE 38
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 790-818 8.00e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.30  E-value: 8.00e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 24641507  790 NGCSRHGQCTLENGEYRCDCIEGWAG-RDC 818
Cdd:cd00053    6 NPCSNGGTCVNTPGSYRCVCPPGYTGdRSC 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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