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Conserved domains on  [gi|24643715|ref|NP_523433|]
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sluggish A, isoform E [Drosophila melanogaster]

Protein Classification

proline dehydrogenase family protein( domain architecture ID 11477047)

proline dehydrogenase family protein similar to human mitochondrial proline dehydrogenase 1 that converts proline to delta-1-pyrroline-5-carboxylate

EC:  1.5.5.-
Gene Ontology:  GO:0004657|GO:0006562|GO:0071949

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PLN02681 PLN02681
proline dehydrogenase
93-668 1.07e-125

proline dehydrogenase


:

Pssm-ID: 215366 [Multi-domain]  Cd Length: 455  Bit Score: 380.59  E-value: 1.07e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715   93 MKQESSQEKNPSPAGSPQRDPLDVSFNDPIAAFKSKTTGELIRAYLVYMICSSEKLVEHNMTLMKWSKNVLGQRLFTLLM 172
Cdd:PLN02681   1 PAGPAATVPPAVTSTTTPASDDVLDFSDHAALFAGLSTSELLRSLLVLQLCAIGPLVDLGEWLLTSPLMVLGRAIVLALV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715  173 KATFYGHFVAGEDQIKIIPTLERLRSFGVKPILDYSVEEDItqeeaekrevessvssagdkkeegsmpqyhvdksfadrr 252
Cdd:PLN02681  81 KATFYSHFCAGEDAEEAARTVRRLWELGLGGILDYAAEDAG--------------------------------------- 121
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715  253 ykvssartyfylNEATCERNMEIFIKCLEAVSDDDRkapravatgatfGTGITAIKLTALGRPQLLLQLSEVimrtrkym 332
Cdd:PLN02681 122 ------------DNAACDRNLEKFLAAIRAAATLPP------------SSSSAAVKITALCPPSLLERVSDL-------- 169
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715  333 edmvggqgnvlthhktikdlekyYATLGDNKDVKeflnnvtsdkegilhlFPWsgivdedsqLSDTFRVPDPQTGQMRRL 412
Cdd:PLN02681 170 -----------------------LRWQDRDPNGK----------------LPW---------KQWSFPLFADSSPLYHAT 201
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715  413 ISQIP--PKEEEMFRNMIRRLNTIVKAAADLDVRIMVDAEQTYFQPAISRITLEMMRKYNKDK--AIVFNTYQCYLRETF 488
Cdd:PLN02681 202 SEPEPltAEEERLLELAHERLQKLCERAAQLGVPLLIDAEYTSLQPAIDYITYDLAREFNKGKdrPIVYGTYQAYLKDAR 281
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715  489 REVNTDLEQAKRQNFYFGAKLVRGAYMDQERDRAKSLGYPDPVNPTFEATTDMYHRTLSECLRRIKlmkdcdddARKIGI 568
Cdd:PLN02681 282 ERLRLDLERSEREGVPLGAKLVRGAYLSLERRLAASLGVPSPVHDTIQDTHACYNRCAEFLLEKAS--------NGDGEV 353
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715  569 MVASHNEDTVRFAIQQMKEIGISPEDKVICFGQLLGMCDYITFPLGQAGYSAYKYIPYGPVEEVLPYLSRRAQENKGVLK 648
Cdd:PLN02681 354 MLATHNVESGELAAAKMNELGLHKGDPRVQFAQLLGMSDNLSFGLGNAGFRVSKYLPYGPVEEVIPYLLRRAEENRGLLS 433
                        570       580
                 ....*....|....*....|
gi 24643715  649 KIKKEKRLLLSEIRRRLMRG 668
Cdd:PLN02681 434 GSAIDRQLLRKELKRRLKAA 453
 
Name Accession Description Interval E-value
PLN02681 PLN02681
proline dehydrogenase
93-668 1.07e-125

proline dehydrogenase


Pssm-ID: 215366 [Multi-domain]  Cd Length: 455  Bit Score: 380.59  E-value: 1.07e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715   93 MKQESSQEKNPSPAGSPQRDPLDVSFNDPIAAFKSKTTGELIRAYLVYMICSSEKLVEHNMTLMKWSKNVLGQRLFTLLM 172
Cdd:PLN02681   1 PAGPAATVPPAVTSTTTPASDDVLDFSDHAALFAGLSTSELLRSLLVLQLCAIGPLVDLGEWLLTSPLMVLGRAIVLALV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715  173 KATFYGHFVAGEDQIKIIPTLERLRSFGVKPILDYSVEEDItqeeaekrevessvssagdkkeegsmpqyhvdksfadrr 252
Cdd:PLN02681  81 KATFYSHFCAGEDAEEAARTVRRLWELGLGGILDYAAEDAG--------------------------------------- 121
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715  253 ykvssartyfylNEATCERNMEIFIKCLEAVSDDDRkapravatgatfGTGITAIKLTALGRPQLLLQLSEVimrtrkym 332
Cdd:PLN02681 122 ------------DNAACDRNLEKFLAAIRAAATLPP------------SSSSAAVKITALCPPSLLERVSDL-------- 169
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715  333 edmvggqgnvlthhktikdlekyYATLGDNKDVKeflnnvtsdkegilhlFPWsgivdedsqLSDTFRVPDPQTGQMRRL 412
Cdd:PLN02681 170 -----------------------LRWQDRDPNGK----------------LPW---------KQWSFPLFADSSPLYHAT 201
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715  413 ISQIP--PKEEEMFRNMIRRLNTIVKAAADLDVRIMVDAEQTYFQPAISRITLEMMRKYNKDK--AIVFNTYQCYLRETF 488
Cdd:PLN02681 202 SEPEPltAEEERLLELAHERLQKLCERAAQLGVPLLIDAEYTSLQPAIDYITYDLAREFNKGKdrPIVYGTYQAYLKDAR 281
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715  489 REVNTDLEQAKRQNFYFGAKLVRGAYMDQERDRAKSLGYPDPVNPTFEATTDMYHRTLSECLRRIKlmkdcdddARKIGI 568
Cdd:PLN02681 282 ERLRLDLERSEREGVPLGAKLVRGAYLSLERRLAASLGVPSPVHDTIQDTHACYNRCAEFLLEKAS--------NGDGEV 353
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715  569 MVASHNEDTVRFAIQQMKEIGISPEDKVICFGQLLGMCDYITFPLGQAGYSAYKYIPYGPVEEVLPYLSRRAQENKGVLK 648
Cdd:PLN02681 354 MLATHNVESGELAAAKMNELGLHKGDPRVQFAQLLGMSDNLSFGLGNAGFRVSKYLPYGPVEEVIPYLLRRAEENRGLLS 433
                        570       580
                 ....*....|....*....|
gi 24643715  649 KIKKEKRLLLSEIRRRLMRG 668
Cdd:PLN02681 434 GSAIDRQLLRKELKRRLKAA 453
Pro_dh pfam01619
Proline dehydrogenase;
412-652 1.47e-85

Proline dehydrogenase;


Pssm-ID: 426348 [Multi-domain]  Cd Length: 296  Bit Score: 270.90  E-value: 1.47e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715   412 LISQIPPKEEE-MFRNMIRRLNTIVKAAADLDVRIMVDAEQTYFQPaisrITLEMMRKYNKDKAI-----VFNTYQCYLR 485
Cdd:pfam01619  66 LHPRYEPLERErVMAELLERLRPLCRLAKELGVRLNIDAEEADRLD----LTLDLFERLLAEPELrgwngVGITLQAYLK 141
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715   486 ETFREVNTDLEQAKRQNFYFGAKLVRGAYMDQERDRAKSLGYPDPVNPTFEATTDMYHRTLSECLRRIKlmkdcdddarK 565
Cdd:pfam01619 142 DALAVLDWLLELARRRGRPLGVRLVKGAYWDSEIKRAQQGGWPYPVFTRKEATDANYEACARFLLENHD----------R 211
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715   566 IGIMVASHNEDTVRFAIQQMKEIGISPEDkvICFGQLLGMCDYITFPLGQAGYSAYKYIPYGPVEEVLPYLSRRAQENKG 645
Cdd:pfam01619 212 IYPQFATHNARSVAAALALAEELGIPPRR--FEFQQLYGMGDNLSFALVAAGYRVRKYAPVGPHEELLAYLVRRLLENTA 289

                  ....*..
gi 24643715   646 VLKKIKK 652
Cdd:pfam01619 290 NSSFVRR 296
PutA COG0506
Proline dehydrogenase [Amino acid transport and metabolism]; Proline dehydrogenase is part of ...
414-639 1.54e-15

Proline dehydrogenase [Amino acid transport and metabolism]; Proline dehydrogenase is part of the Pathway/BioSystem: Proline degradation


Pssm-ID: 440272 [Multi-domain]  Cd Length: 975  Bit Score: 80.86  E-value: 1.54e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715 414 SQIPP-KEEEMFRNMIRRLNTIVKAAADLDVRIMVDAEQtyfqpaiSR---ITLEMMRKYNKDKA--------IVFntyQ 481
Cdd:COG0506 187 PRYSPaQRERVVEELLERLRPLARAAREAGIFVTIDMEE-------YDrldLTLDVFERLLADPElagwpgvgIVL---Q 256
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715 482 CYLRETFREVNTDLEQAKRQnfyfGAK----LVRGAYMDQERDRAKSLGYPDPVNPTFEATTDMYHRtlseCLRriKLMk 557
Cdd:COG0506 257 AYLKRAEADLDRLAALARRG----GRRirvrLVKGAYWDPEIVRAQVHGWPYPVFTRKADTDANYLR----CAR--KLL- 325
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715 558 dcdDDARKIGIMVASHNEDTVRFAIQQMKEIGISPEDkvICFGQLLGMCDyitfPL-----GQAGYSAYKYIPYGPVEEV 632
Cdd:COG0506 326 ---EAGDAIYPQFATHNARTIAAALALAGERGRPPDR--FEFQMLYGMGE----DLqralaAVDGGRLLLYCPVVAPVGG 396

                ....*..
gi 24643715 633 LPYLSRR 639
Cdd:COG0506 397 DAALAYL 403
 
Name Accession Description Interval E-value
PLN02681 PLN02681
proline dehydrogenase
93-668 1.07e-125

proline dehydrogenase


Pssm-ID: 215366 [Multi-domain]  Cd Length: 455  Bit Score: 380.59  E-value: 1.07e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715   93 MKQESSQEKNPSPAGSPQRDPLDVSFNDPIAAFKSKTTGELIRAYLVYMICSSEKLVEHNMTLMKWSKNVLGQRLFTLLM 172
Cdd:PLN02681   1 PAGPAATVPPAVTSTTTPASDDVLDFSDHAALFAGLSTSELLRSLLVLQLCAIGPLVDLGEWLLTSPLMVLGRAIVLALV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715  173 KATFYGHFVAGEDQIKIIPTLERLRSFGVKPILDYSVEEDItqeeaekrevessvssagdkkeegsmpqyhvdksfadrr 252
Cdd:PLN02681  81 KATFYSHFCAGEDAEEAARTVRRLWELGLGGILDYAAEDAG--------------------------------------- 121
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715  253 ykvssartyfylNEATCERNMEIFIKCLEAVSDDDRkapravatgatfGTGITAIKLTALGRPQLLLQLSEVimrtrkym 332
Cdd:PLN02681 122 ------------DNAACDRNLEKFLAAIRAAATLPP------------SSSSAAVKITALCPPSLLERVSDL-------- 169
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715  333 edmvggqgnvlthhktikdlekyYATLGDNKDVKeflnnvtsdkegilhlFPWsgivdedsqLSDTFRVPDPQTGQMRRL 412
Cdd:PLN02681 170 -----------------------LRWQDRDPNGK----------------LPW---------KQWSFPLFADSSPLYHAT 201
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715  413 ISQIP--PKEEEMFRNMIRRLNTIVKAAADLDVRIMVDAEQTYFQPAISRITLEMMRKYNKDK--AIVFNTYQCYLRETF 488
Cdd:PLN02681 202 SEPEPltAEEERLLELAHERLQKLCERAAQLGVPLLIDAEYTSLQPAIDYITYDLAREFNKGKdrPIVYGTYQAYLKDAR 281
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715  489 REVNTDLEQAKRQNFYFGAKLVRGAYMDQERDRAKSLGYPDPVNPTFEATTDMYHRTLSECLRRIKlmkdcdddARKIGI 568
Cdd:PLN02681 282 ERLRLDLERSEREGVPLGAKLVRGAYLSLERRLAASLGVPSPVHDTIQDTHACYNRCAEFLLEKAS--------NGDGEV 353
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715  569 MVASHNEDTVRFAIQQMKEIGISPEDKVICFGQLLGMCDYITFPLGQAGYSAYKYIPYGPVEEVLPYLSRRAQENKGVLK 648
Cdd:PLN02681 354 MLATHNVESGELAAAKMNELGLHKGDPRVQFAQLLGMSDNLSFGLGNAGFRVSKYLPYGPVEEVIPYLLRRAEENRGLLS 433
                        570       580
                 ....*....|....*....|
gi 24643715  649 KIKKEKRLLLSEIRRRLMRG 668
Cdd:PLN02681 434 GSAIDRQLLRKELKRRLKAA 453
Pro_dh pfam01619
Proline dehydrogenase;
412-652 1.47e-85

Proline dehydrogenase;


Pssm-ID: 426348 [Multi-domain]  Cd Length: 296  Bit Score: 270.90  E-value: 1.47e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715   412 LISQIPPKEEE-MFRNMIRRLNTIVKAAADLDVRIMVDAEQTYFQPaisrITLEMMRKYNKDKAI-----VFNTYQCYLR 485
Cdd:pfam01619  66 LHPRYEPLERErVMAELLERLRPLCRLAKELGVRLNIDAEEADRLD----LTLDLFERLLAEPELrgwngVGITLQAYLK 141
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715   486 ETFREVNTDLEQAKRQNFYFGAKLVRGAYMDQERDRAKSLGYPDPVNPTFEATTDMYHRTLSECLRRIKlmkdcdddarK 565
Cdd:pfam01619 142 DALAVLDWLLELARRRGRPLGVRLVKGAYWDSEIKRAQQGGWPYPVFTRKEATDANYEACARFLLENHD----------R 211
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715   566 IGIMVASHNEDTVRFAIQQMKEIGISPEDkvICFGQLLGMCDYITFPLGQAGYSAYKYIPYGPVEEVLPYLSRRAQENKG 645
Cdd:pfam01619 212 IYPQFATHNARSVAAALALAEELGIPPRR--FEFQQLYGMGDNLSFALVAAGYRVRKYAPVGPHEELLAYLVRRLLENTA 289

                  ....*..
gi 24643715   646 VLKKIKK 652
Cdd:pfam01619 290 NSSFVRR 296
PutA COG0506
Proline dehydrogenase [Amino acid transport and metabolism]; Proline dehydrogenase is part of ...
414-639 1.54e-15

Proline dehydrogenase [Amino acid transport and metabolism]; Proline dehydrogenase is part of the Pathway/BioSystem: Proline degradation


Pssm-ID: 440272 [Multi-domain]  Cd Length: 975  Bit Score: 80.86  E-value: 1.54e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715 414 SQIPP-KEEEMFRNMIRRLNTIVKAAADLDVRIMVDAEQtyfqpaiSR---ITLEMMRKYNKDKA--------IVFntyQ 481
Cdd:COG0506 187 PRYSPaQRERVVEELLERLRPLARAAREAGIFVTIDMEE-------YDrldLTLDVFERLLADPElagwpgvgIVL---Q 256
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715 482 CYLRETFREVNTDLEQAKRQnfyfGAK----LVRGAYMDQERDRAKSLGYPDPVNPTFEATTDMYHRtlseCLRriKLMk 557
Cdd:COG0506 257 AYLKRAEADLDRLAALARRG----GRRirvrLVKGAYWDPEIVRAQVHGWPYPVFTRKADTDANYLR----CAR--KLL- 325
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643715 558 dcdDDARKIGIMVASHNEDTVRFAIQQMKEIGISPEDkvICFGQLLGMCDyitfPL-----GQAGYSAYKYIPYGPVEEV 632
Cdd:COG0506 326 ---EAGDAIYPQFATHNARTIAAALALAGERGRPPDR--FEFQMLYGMGE----DLqralaAVDGGRLLLYCPVVAPVGG 396

                ....*..
gi 24643715 633 LPYLSRR 639
Cdd:COG0506 397 DAALAYL 403
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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