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Conserved domains on  [gi|24580686|ref|NP_523446|]
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dachsous, isoform A [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1158-1252 1.42e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 128.97  E-value: 1.42e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 1158 YEFRIEENLRRGSVVGVVTASDLDLGENAAIRYSLLPINSS--FQVHPVTGEISTREPLDRELRELYDLVVEARDQGTPV 1235
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                         90
                 ....*....|....*..
gi 24580686 1236 RSARVPVRIHVSDVNDN 1252
Cdd:cd11304   82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 291-389 3.37e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.12  E-value: 3.37e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686  291 YFATVPENATVGTSVLQVYASDTDADENGLVEYAInrRQSDKEQMFRIDPRTGAIYINKALDFETKELHELVVVAKDHGE 370
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 24580686  371 QPLETTAFVSIRVTDVNDN 389
Cdd:cd11304   80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 509-607 7.41e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.96  E-value: 7.41e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686  509 YHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLaeTPETHAQWFQIDPQTGLITTRSHIDCETEPVPQLTVVARDGGV 588
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 24580686  589 PPLSSTATVLVTIHDVNDN 607
Cdd:cd11304   80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1853-1948 1.55e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.19  E-value: 1.55e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 1853 YGLSVPENSEPG-VIHTVVASDLDEGPNADLIYSITGGNLGNKFSIDSSSGELS-ARPLDREQHSRYTLQIQASDRGQPk 1930
Cdd:cd11304    2 YEVSVPENAPPGtVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITtAKPLDREEQSSYTLTVTATDGGGP- 80

                         90
                 ....*....|....*...
gi 24580686 1931 SRQGHCNITIFVEDQNDN 1948
Cdd:cd11304   81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1040-1149 1.84e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.81  E-value: 1.84e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 1040 EYSVNVSESRSINAQIIQVNASDLDTGNNARITYrivdagvdnvtnSISSSDVSQHFGIFPNSGWIYLRAPLDRETRDRY 1119
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTY------------SIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSY 68

                         90       100       110
                 ....*....|....*....|....*....|
gi 24580686 1120 QLTVLATDNGTPAAHAKTRVIVRVLDANDN 1149
Cdd:cd11304   69 TLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1263-1361 3.43e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.04  E-value: 3.43e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 1263 VVSVREEQPPGTEVVRVRAVDRDHGQNASITYSIVKGrdsDGHGLFSIDPTSGVIRTRVVLDHEERSIYRLGVAASDGGN 1342
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 24580686 1343 PPRETVRMLRVEVLDLNDN 1361
Cdd:cd11304   80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1957-2053 3.71e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.04  E-value: 3.71e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 1957 YTGSVQEDAPLGTSVVQISAVDADLGVNARLVYSLANETQWQ-FAIDGQSGLITTVGKLDRELQASYNFMVLATDGGRyE 2035
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG-P 80

                         90
                 ....*....|....*...
gi 24580686 2036 VRSATVPVQINVLDINDN 2053
Cdd:cd11304   81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2326-2424 1.15e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.50  E-value: 1.15e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 2326 QFVATVSEGNNKGTFVAQVHAFDSDAGSNARLRYHIVDGNHDNAFVIEPAfSGIVRTNIVLDREIRDIYKLKIIATDEGV 2405
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPS-TGEITTAKPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 24580686 2406 PQMTGTATIRVQIVDVNDN 2424
Cdd:cd11304   80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 937-1032 1.91e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.03  E-value: 1.91e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686  937 RISVPESAELGAPLYAAHAHDKDSGSSGQVTYSLVKESGKGLFAIDARSGHLILSQHLDYESSQRHTLIVTATDGGVPSL 1016
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                         90
                 ....*....|....*.
gi 24580686 1017 STNLTILVDVQDVNDN 1032
Cdd:cd11304   83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 832-927 4.63e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.48  E-value: 4.63e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686  832 YNYYVKEDIPRGTVVGSVIAASGDVAHRSPVRYSIYSGDPDGYFSIETNSGNIRIAKPLDHEAKSQVLLNIQAT-LGEPP 910
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATdGGGPP 81

                         90
                 ....*....|....*..
gi 24580686  911 VYGHTQVNIEVEDVNDN 927
Cdd:cd11304   82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 616-711 1.82e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.78  E-value: 1.82e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686  616 YNVSVAENEPVGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTeFEVRSASGEICIAGELDFERRSSYEFPVLATDRGG- 694
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL-FSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                         90
                 ....*....|....*...
gi 24580686  695 -LSTTAMIKMQLTDVNDN 711
Cdd:cd11304   81 pLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1489-1598 3.78e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.31  E-value: 3.78e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 1489 PIDLQVSEATPVGTIIHNFTATDADTGTNGDLQYRLiryfpqlneSQEQAMSLFRMDSLTGALSLQAPLDFEAVQEYLLI 1568
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI---------VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLT 71

                         90       100       110
                 ....*....|....*....|....*....|
gi 24580686 1569 VQALDQSSNvteRLQTSVTVRLRILDANDH 1598
Cdd:cd11304   72 VTATDGGGP---PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 178-282 7.93e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 7.93e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686  178 SMHIEFPENTPREVKRTLLPARDLDLEPYNTQRYNIVSGNVNDAFRLSSHrerDGVLYLdlqiSGFLDRETTPGYSLLIE 257
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPS---TGEITT----AKPLDREEQSSYTLTVT 73

                         90       100
                 ....*....|....*....|....*
gi 24580686  258 ALDGGTPPLRGFMTVNITIQDVNDN 282
Cdd:cd11304   74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1723-1843 5.76e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.76  E-value: 5.76e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 1723 VYRATILENVPSGSFVLQVTAKSLHGAENANLSYEIPAGVANDLFHVDWQRGIITTRGQFDRESQASYVLPVYVRDANRQ 1802
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 24580686 1803 StLSSSavrkqrssdsigdtsngqhfdvATIYITVGDVNDN 1843
Cdd:cd11304   81 P-LSST----------------------ATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2758-2858 1.17e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 1.17e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 2758 YEAEISELAPLRYSIAQLQAIDADQEntPNSEVVYDITSGNDEHMFTIDLVTGVLFVNNRLDYDSGAkSYELIIRACDsH 2837
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQS-SYTLTVTATD-G 77

                         90       100
                 ....*....|....*....|.
gi 24580686 2838 HQRPLCSLQPFRLELHDENDN 2858
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1614-1710 1.85e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.52  E-value: 1.85e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 1614 SLFISDATRIGEVVAHIVAVDEDSGDNGQLTYEITGGNGEGRFRINSQTGIIELVKSLppateDVEKGGRFNLIIGAKDH 1693
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPL-----DREEQSSYTLTVTATDG 77

                         90
                 ....*....|....*..
gi 24580686 1694 GQPePKKSSLNLHLIVQ 1710
Cdd:cd11304   78 GGP-PLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 719-820 3.16e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.14  E-value: 3.16e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686  719 EYKVSLRESpkassQASSTPIVAVVATDPDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPdmLSVRTQPMHMLNIS 798
Cdd:cd11304    1 SYEVSVPEN-----APPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKP--LDREEQSSYTLTVT 73

                         90       100
                 ....*....|....*....|..
gi 24580686  799 ATDGGNLRSNADAVVFLSIIDA 820
Cdd:cd11304   74 ATDGGGPPLSSTATVTITVLDV 95
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 406-500 1.82e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.83  E-value: 1.82e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686  406 ISESAQPGEFVARISVHDPDSkTEYANVNVTLNGGD--GHFALTTRDNSIYLVivhLPLDREIVSNYTLSVVATDKGTPP 483
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDS-GENGEVTYSIVSGNedGLFSIDPSTGEITTA---KPLDREEQSSYTLTVTATDGGGPP 81

                         90
                 ....*....|....*..
gi 24580686  484 LHASKSIFLRITDVNDN 500
Cdd:cd11304   82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2061-2154 7.69e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 7.69e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 2061 PYIGQVPALIQPGQTLLKVQALDADLGANAEIVYSLNAENSavSAKFRINPSTGALSASQSLASESGKLLHLEVVARDKG 2140
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE--DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                         90
                 ....*....|....
gi 24580686 2141 NPPQSSLGLIELLI 2154
Cdd:cd11304   79 GPPLSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2434-2528 1.43e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.13  E-value: 1.43e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 2434 VTVSEATELGAVITSISANDVDTYPA--LTYRLgaestVDIENMSIFALDRYSGKLVLKRRLDYELQQEYELDVIASDA- 2510
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENgeVTYSI-----VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGg 78

                         90       100
                 ....*....|....*....|
gi 24580686 2511 --AHEARTVLTVRVNDENDN 2528
Cdd:cd11304   79 gpPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2866-2960 9.45e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.82  E-value: 9.45e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 2866 EYVHFLAENEPVGSSVFRAHASDLDKGPFGQLNYSIgpapSDESSWKMFRVDSESGLVTSAFVFDYEQRQRYDMELLASD 2945
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI----VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                         90
                 ....*....|....*..
gi 24580686 2946 MGG--KKASVAVRVEIE 2960
Cdd:cd11304   77 GGGppLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1369-1481 1.04e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.12  E-value: 1.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 1369 SLVFRVREDAALGHVVGSISPIerPADVVRNSveesfedlRVTYTLnplTKDLIEAAFDIDRHSGNLVVARLLDREVQSE 1448
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSAT--DPDSGENG--------EVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQSS 67

                         90       100       110
                 ....*....|....*....|....*....|...
gi 24580686 1449 FRLEIRALDttASNNPQSSAITVKIEVADVNDN 1481
Cdd:cd11304   68 YTLTVTATD--GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2549-2641 1.26e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.26  E-value: 1.26e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 2549 EISESLSVDFDLLTVNATDADSeGNNSKVIYIIEPAQEG--FSVHPSNGVVSVNMS--RLQPAVsssgdYFVRIIAKDAG 2624
Cdd:cd11304    5 SVPENAPPGTVVLTVSATDPDS-GENGEVTYSIVSGNEDglFSIDPSTGEITTAKPldREEQSS-----YTLTVTATDGG 78

                         90       100
                 ....*....|....*....|
gi 24580686 2625 KPALKSSTLLRVQ---ANDN 2641
Cdd:cd11304   79 GPPLSSTATVTITvldVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2985-3071 2.12e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.02  E-value: 2.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 2985 PQGYVVGQVTATDSDSGPDGRVVYQLSA--PHSHFKVNRSSGAVLIKRklKLDgdgdgnlYMDGRDISLVISASSGRHNS 3062
Cdd:cd11304   11 PPGTVVLTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPSTGEITTAK--PLD-------REEQSSYTLTVTATDGGGPP 81


                 ....*....
gi 24580686 3063 LSSMAVVEI 3071
Cdd:cd11304   82 LSSTATVTI 90
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2652-2748 2.56e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 59.63  E-value: 2.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 2652 QYRAQISEAAPLGSVVLQLGqdALDQ--------SLAIIAGNEESAFEL-LQSKAIVLVKPLDRERNDLYKLRLVLSHPH 2722
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVS--ATDPdsgengevTYSIVSGNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                         90       100
                 ....*....|....*....|....*.
gi 24580686 2723 GPPlisslnSSSGISVIITILDANDN 2748
Cdd:cd11304   79 GPP------LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 111-172 5.29e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.43  E-value: 5.29e-09
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24580686     111 YIIVAEaGVETDLAIDRATGEIRTKVKLDRETRASYSLVAI-------PLSGrNIRVLVTVKDENDNAP 172
Cdd:smart00112   15 YSILSG-NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEatdgggpPLSS-TATVTITVLDVNDNAP 81
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2171-2232 8.91e-06

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member pfam00028:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 92  Bit Score: 46.52  E-value: 8.91e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24580686   2171 YRVMLKENSPSGTRLLQVVALRSD-GRRQKVQFSFGAGNEDGILSLDSLSGEIRVNKPhlLDY 2232
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDlGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKP--LDR 61
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1158-1252 1.42e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 128.97  E-value: 1.42e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 1158 YEFRIEENLRRGSVVGVVTASDLDLGENAAIRYSLLPINSS--FQVHPVTGEISTREPLDRELRELYDLVVEARDQGTPV 1235
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                         90
                 ....*....|....*..
gi 24580686 1236 RSARVPVRIHVSDVNDN 1252
Cdd:cd11304   82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 291-389 3.37e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.12  E-value: 3.37e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686  291 YFATVPENATVGTSVLQVYASDTDADENGLVEYAInrRQSDKEQMFRIDPRTGAIYINKALDFETKELHELVVVAKDHGE 370
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 24580686  371 QPLETTAFVSIRVTDVNDN 389
Cdd:cd11304   80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 509-607 7.41e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.96  E-value: 7.41e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686  509 YHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLaeTPETHAQWFQIDPQTGLITTRSHIDCETEPVPQLTVVARDGGV 588
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 24580686  589 PPLSSTATVLVTIHDVNDN 607
Cdd:cd11304   80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1853-1948 1.55e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.19  E-value: 1.55e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 1853 YGLSVPENSEPG-VIHTVVASDLDEGPNADLIYSITGGNLGNKFSIDSSSGELS-ARPLDREQHSRYTLQIQASDRGQPk 1930
Cdd:cd11304    2 YEVSVPENAPPGtVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITtAKPLDREEQSSYTLTVTATDGGGP- 80

                         90
                 ....*....|....*...
gi 24580686 1931 SRQGHCNITIFVEDQNDN 1948
Cdd:cd11304   81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1040-1149 1.84e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.81  E-value: 1.84e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 1040 EYSVNVSESRSINAQIIQVNASDLDTGNNARITYrivdagvdnvtnSISSSDVSQHFGIFPNSGWIYLRAPLDRETRDRY 1119
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTY------------SIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSY 68

                         90       100       110
                 ....*....|....*....|....*....|
gi 24580686 1120 QLTVLATDNGTPAAHAKTRVIVRVLDANDN 1149
Cdd:cd11304   69 TLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1263-1361 3.43e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.04  E-value: 3.43e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 1263 VVSVREEQPPGTEVVRVRAVDRDHGQNASITYSIVKGrdsDGHGLFSIDPTSGVIRTRVVLDHEERSIYRLGVAASDGGN 1342
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 24580686 1343 PPRETVRMLRVEVLDLNDN 1361
Cdd:cd11304   80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1957-2053 3.71e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.04  E-value: 3.71e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 1957 YTGSVQEDAPLGTSVVQISAVDADLGVNARLVYSLANETQWQ-FAIDGQSGLITTVGKLDRELQASYNFMVLATDGGRyE 2035
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG-P 80

                         90
                 ....*....|....*...
gi 24580686 2036 VRSATVPVQINVLDINDN 2053
Cdd:cd11304   81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2326-2424 1.15e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.50  E-value: 1.15e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 2326 QFVATVSEGNNKGTFVAQVHAFDSDAGSNARLRYHIVDGNHDNAFVIEPAfSGIVRTNIVLDREIRDIYKLKIIATDEGV 2405
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPS-TGEITTAKPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 24580686 2406 PQMTGTATIRVQIVDVNDN 2424
Cdd:cd11304   80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 937-1032 1.91e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.03  E-value: 1.91e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686  937 RISVPESAELGAPLYAAHAHDKDSGSSGQVTYSLVKESGKGLFAIDARSGHLILSQHLDYESSQRHTLIVTATDGGVPSL 1016
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                         90
                 ....*....|....*.
gi 24580686 1017 STNLTILVDVQDVNDN 1032
Cdd:cd11304   83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 832-927 4.63e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.48  E-value: 4.63e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686  832 YNYYVKEDIPRGTVVGSVIAASGDVAHRSPVRYSIYSGDPDGYFSIETNSGNIRIAKPLDHEAKSQVLLNIQAT-LGEPP 910
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATdGGGPP 81

                         90
                 ....*....|....*..
gi 24580686  911 VYGHTQVNIEVEDVNDN 927
Cdd:cd11304   82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 954-1034 1.32e-26

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 105.51  E-value: 1.32e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686     954 HAHDKDSGSSGQVTYSLVKESGKGLFAIDARSGHLILSQHLDYESSQRHTLIVTATDGGVPSLSTNLTILVDVQDVNDNP 1033
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 24580686    1034 P 1034
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
1158-1246 4.33e-26

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 104.30  E-value: 4.33e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   1158 YEFRIEENLRRGSVVGVVTASDLDLGENAAIRYSLL--PINSSFQVHPVTGEISTREPLDRELRELYDLVVEARDQGTPV 1235
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 24580686   1236 RSARVPVRIHV 1246
Cdd:pfam00028   81 LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2345-2426 1.65e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 102.43  E-value: 1.65e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    2345 HAFDSDAGSNARLRYHIVDGNHDNAFVIEPaFSGIVRTNIVLDREIRDIYKLKIIATDEGVPQMTGTATIRVQIVDVNDN 2424
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDP-ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 24580686    2425 QP 2426
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 616-711 1.82e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.78  E-value: 1.82e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686  616 YNVSVAENEPVGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTeFEVRSASGEICIAGELDFERRSSYEFPVLATDRGG- 694
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL-FSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                         90
                 ....*....|....*...
gi 24580686  695 -LSTTAMIKMQLTDVNDN 711
Cdd:cd11304   81 pLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 528-609 2.34e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 102.04  E-value: 2.34e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686     528 AHDRDEGLNSALTYSLaeTPETHAQWFQIDPQTGLITTRSHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDN 607
Cdd:smart00112    2 ATDADSGENGKVTYSI--LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 24580686     608 EP 609
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1176-1254 3.29e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 101.66  E-value: 3.29e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    1176 TASDLDLGENAAIRYSLLP--INSSFQVHPVTGEISTREPLDRELRELYDLVVEARDQGTPVRSARVPVRIHVSDVNDNA 1253
Cdd:smart00112    1 SATDADSGENGKVTYSILSgnDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 24580686    1254 P 1254
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1870-1950 3.63e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 101.27  E-value: 3.63e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    1870 VASDLDEGPNADLIYSITGGNLGNKFSIDSSSGELS-ARPLDREQHSRYTLQIQASDRGQPkSRQGHCNITIFVEDQNDN 1948
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITtTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLDVNDN 79


                    ..
gi 24580686    1949 AP 1950
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
1263-1356 7.48e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 100.84  E-value: 7.48e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   1263 VVSVREEQPPGTEVVRVRAVDRDHGQNASITYSIVKGRDSdghGLFSIDPTSGVIRTRVVLDHEERSIYRLGVAASDGGN 1342
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPG---GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 24580686   1343 PPRETVRMLRVEVL 1356
Cdd:pfam00028   79 PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
509-602 1.88e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 99.68  E-value: 1.88e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    509 YHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLAETPEthAQWFQIDPQTGLITTRSHIDCETEPVPQLTVVARDGGV 588
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGP--GGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 24580686    589 PPLSSTATVLVTIH 602
Cdd:pfam00028   79 PPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1489-1598 3.78e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.31  E-value: 3.78e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 1489 PIDLQVSEATPVGTIIHNFTATDADTGTNGDLQYRLiryfpqlneSQEQAMSLFRMDSLTGALSLQAPLDFEAVQEYLLI 1568
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI---------VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLT 71

                         90       100       110
                 ....*....|....*....|....*....|
gi 24580686 1569 VQALDQSSNvteRLQTSVTVRLRILDANDH 1598
Cdd:cd11304   72 VTATDGGGP---PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1280-1363 1.07e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 97.42  E-value: 1.07e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    1280 RAVDRDHGQNASITYSIVKGrdsDGHGLFSIDPTSGVIRTRVVLDHEERSIYRLGVAASDGGNPPRETVRMLRVEVLDLN 1359
Cdd:smart00112    1 SATDADSGENGKVTYSILSG---NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 24580686    1360 DNRP 1363
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1059-1151 2.80e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.88  E-value: 2.80e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    1059 NASDLDTGNNARITYRIVDAGVDNvtnsisssdvsqHFGIFPNSGWIYLRAPLDRETRDRYQLTVLATDNGTPAAHAKTR 1138
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDG------------LFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTAT 68

                            90
                    ....*....|...
gi 24580686    1139 VIVRVLDANDNDP 1151
Cdd:smart00112   69 VTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 310-391 5.65e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.11  E-value: 5.65e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686     310 ASDTDADENGLVEYAINrrQSDKEQMFRIDPRTGAIYINKALDFETKELHELVVVAKDHGEQPLETTAFVSIRVTDVNDN 389
Cdd:smart00112    2 ATDADSGENGKVTYSIL--SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 24580686     390 QP 391
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
291-384 7.15e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.45  E-value: 7.15e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    291 YFATVPENATVGTSVLQVYASDTDADENGLVEYAInrRQSDKEQMFRIDPRTGAIYINKALDFETKELHELVVVAKDHGE 370
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI--LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 24580686    371 QPLETTAFVSIRVT 384
Cdd:pfam00028   79 PPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 178-282 7.93e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 7.93e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686  178 SMHIEFPENTPREVKRTLLPARDLDLEPYNTQRYNIVSGNVNDAFRLSSHrerDGVLYLdlqiSGFLDRETTPGYSLLIE 257
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPS---TGEITT----AKPLDREEQSSYTLTVT 73

                         90       100
                 ....*....|....*....|....*
gi 24580686  258 ALDGGTPPLRGFMTVNITIQDVNDN 282
Cdd:cd11304   74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1041-1144 8.27e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.06  E-value: 8.27e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   1041 YSVNVSESRSINAQIIQVNASDLDTGNNARITYrivdagvdnvtnSISSSDVSQHFGIFPNSGWIYLRAPLDRETRDRYQ 1120
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFY------------SILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYE 68

                           90       100
                   ....*....|....*....|....
gi 24580686   1121 LTVLATDNGTPAAHAKTRVIVRVL 1144
Cdd:pfam00028   69 LTVEATDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
2327-2418 1.14e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 94.67  E-value: 1.14e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   2327 FVATVSEGNNKGTFVAQVHAFDSDAGSNARLRYHIVDGNHDNAFVIEPAfSGIVRTNIVLDREIRDIYKLKIIATDEGVP 2406
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPD-TGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|..
gi 24580686   2407 QMTGTATIRVQI 2418
Cdd:pfam00028   80 PLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1723-1843 5.76e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.76  E-value: 5.76e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 1723 VYRATILENVPSGSFVLQVTAKSLHGAENANLSYEIPAGVANDLFHVDWQRGIITTRGQFDRESQASYVLPVYVRDANRQ 1802
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 24580686 1803 StLSSSavrkqrssdsigdtsngqhfdvATIYITVGDVNDN 1843
Cdd:cd11304   81 P-LSST----------------------ATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1975-2055 9.13e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 91.64  E-value: 9.13e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    1975 SAVDADLGVNARLVYSLANETQWQ-FAIDGQSGLITTVGKLDRELQASYNFMVLATDGGRYEvRSATVPVQINVLDINDN 2053
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGlFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP-LSSTATVTITVLDVNDN 79


                    ..
gi 24580686    2054 RP 2055
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2758-2858 1.17e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 1.17e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 2758 YEAEISELAPLRYSIAQLQAIDADQEntPNSEVVYDITSGNDEHMFTIDLVTGVLFVNNRLDYDSGAkSYELIIRACDsH 2837
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQS-SYTLTVTATD-G 77

                         90       100
                 ....*....|....*....|.
gi 24580686 2838 HQRPLCSLQPFRLELHDENDN 2858
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1856-1940 1.50e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 91.59  E-value: 1.50e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   1856 SVPENSEPGV-IHTVVASDLDEGPNADLIYSITGGNLGNKFSIDSSSGELS-ARPLDREQHSRYTLQIQASDRG-QPKSR 1932
Cdd:pfam00028    4 SVPENAPVGTeVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDIStTKPLDRESIGEYELTVEATDSGgPPLSS 83


                   ....*...
gi 24580686   1933 QGHCNITI 1940
Cdd:pfam00028   84 TATVTITV 91
Cadherin pfam00028
Cadherin domain;
1957-2048 7.33e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.67  E-value: 7.33e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   1957 YTGSVQEDAPLGTSVVQISAVDADLGVNARLVYSLA--NETQWqFAIDGQSGLITTVGKLDRELQASYNFMVLATDGGRY 2034
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGN-FRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|....
gi 24580686   2035 eVRSATVPVQINVL 2048
Cdd:pfam00028   80 -PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1614-1710 1.85e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.52  E-value: 1.85e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 1614 SLFISDATRIGEVVAHIVAVDEDSGDNGQLTYEITGGNGEGRFRINSQTGIIELVKSLppateDVEKGGRFNLIIGAKDH 1693
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPL-----DREEQSSYTLTVTATDG 77

                         90
                 ....*....|....*..
gi 24580686 1694 GQPePKKSSLNLHLIVQ 1710
Cdd:cd11304   78 GGP-PLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 719-820 3.16e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.14  E-value: 3.16e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686  719 EYKVSLRESpkassQASSTPIVAVVATDPDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPdmLSVRTQPMHMLNIS 798
Cdd:cd11304    1 SYEVSVPEN-----APPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKP--LDREEQSSYTLTVT 73

                         90       100
                 ....*....|....*....|..
gi 24580686  799 ATDGGNLRSNADAVVFLSIIDA 820
Cdd:cd11304   74 ATDGGGPPLSSTATVTITVLDV 95
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 406-500 1.82e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.83  E-value: 1.82e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686  406 ISESAQPGEFVARISVHDPDSkTEYANVNVTLNGGD--GHFALTTRDNSIYLVivhLPLDREIVSNYTLSVVATDKGTPP 483
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDS-GENGEVTYSIVSGNedGLFSIDPSTGEITTA---KPLDREEQSSYTLTVTATDGGGPP 81

                         90
                 ....*....|....*..
gi 24580686  484 LHASKSIFLRITDVNDN 500
Cdd:cd11304   82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 855-929 6.78e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.55  E-value: 6.78e-19
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24580686     855 DVAHRSPVRYSIYSGDPDGYFSIETNSGNIRIAKPLDHEAKSQVLLNIQAT-LGEPPVYGHTQVNIEVEDVNDNAP 929
Cdd:smart00112    6 DSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATdGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2061-2154 7.69e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 7.69e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 2061 PYIGQVPALIQPGQTLLKVQALDADLGANAEIVYSLNAENSavSAKFRINPSTGALSASQSLASESGKLLHLEVVARDKG 2140
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE--DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                         90
                 ....*....|....
gi 24580686 2141 NPPQSSLGLIELLI 2154
Cdd:cd11304   79 GPPLSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2434-2528 1.43e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.13  E-value: 1.43e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 2434 VTVSEATELGAVITSISANDVDTYPA--LTYRLgaestVDIENMSIFALDRYSGKLVLKRRLDYELQQEYELDVIASDA- 2510
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENgeVTYSI-----VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGg 78

                         90       100
                 ....*....|....*....|
gi 24580686 2511 --AHEARTVLTVRVNDENDN 2528
Cdd:cd11304   79 gpPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
938-1027 4.68e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.58  E-value: 4.68e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    938 ISVPESAELGAPLYAAHAHDKDSGSSGQVTYSLVKESGKGLFAIDARSGHLILSQHLDYESSQRHTLIVTATDGGVPSLS 1017
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82

                           90
                   ....*....|
gi 24580686   1018 TNLTILVDVQ 1027
Cdd:pfam00028   83 STATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 634-713 6.00e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.86  E-value: 6.00e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686     634 SASDPDCGVNAMVNYTIGEGFkHLTEFEVRSASGEICIAGELDFERRSSYEFPVLATDRGG--LSTTAMIKMQLTDVNDN 711
Cdd:smart00112    1 SATDADSGENGKVTYSILSGN-DDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDN 79


                    ..
gi 24580686     712 RP 713
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 198-284 7.01e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.86  E-value: 7.01e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686     198 ARDLDLEPYNTQRYNIVSGNVNDAFRLSSHrerDGVLYLDLQisgfLDRETTPGYSLLIEALDGGTPPLRGFMTVNITIQ 277
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPE---TGEITTTKP----LDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                    ....*..
gi 24580686     278 DVNDNQP 284
Cdd:smart00112   75 DVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2866-2960 9.45e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.82  E-value: 9.45e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 2866 EYVHFLAENEPVGSSVFRAHASDLDKGPFGQLNYSIgpapSDESSWKMFRVDSESGLVTSAFVFDYEQRQRYDMELLASD 2945
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI----VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                         90
                 ....*....|....*..
gi 24580686 2946 MGG--KKASVAVRVEIE 2960
Cdd:cd11304   77 GGGppLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1631-1717 1.07e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 1.07e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    1631 VAVDEDSGDNGQLTYEITGGNGEGRFRINSQTGIIELVKSLppateDVEKGGRFNLIIGAKDHGQPePKKSSLNLHLIVQ 1710
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPL-----DREEQPEYTLTVEATDGGGP-PLSSTATVTITVL 74


                    ....*..
gi 24580686    1711 GSHNNPP 1717
Cdd:smart00112   75 DVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1508-1600 1.41e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 79.70  E-value: 1.41e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    1508 TATDADTGTNGDLQYRLiryfpqlneSQEQAMSLFRMDSLTGALSLQAPLDFEAVQEYLLIVQALDQSSNvteRLQTSVT 1587
Cdd:smart00112    1 SATDADSGENGKVTYSI---------LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP---PLSSTAT 68

                            90
                    ....*....|...
gi 24580686    1588 VRLRILDANDHAP 1600
Cdd:smart00112   69 VTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1369-1481 1.04e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.12  E-value: 1.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 1369 SLVFRVREDAALGHVVGSISPIerPADVVRNSveesfedlRVTYTLnplTKDLIEAAFDIDRHSGNLVVARLLDREVQSE 1448
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSAT--DPDSGENG--------EVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQSS 67

                         90       100       110
                 ....*....|....*....|....*....|...
gi 24580686 1449 FRLEIRALDttASNNPQSSAITVKIEVADVNDN 1481
Cdd:cd11304   68 YTLTVTATD--GGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
832-922 1.97e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.96  E-value: 1.97e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    832 YNYYVKEDIPRGTVVGSVIAASGDVAHRSPVRYSIYSGDPDGYFSIETNSGNIRIAKPLDHEAKSQVLLNIQAT-LGEPP 910
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATdSGGPP 80

                           90
                   ....*....|..
gi 24580686    911 VYGHTQVNIEVE 922
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2776-2860 7.53e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.08  E-value: 7.53e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    2776 QAIDADQEntPNSEVVYDITSGNDEHMFTIDLVTGVLFVNNRLDYDSGaKSYELIIRACDsHHQRPLCSLQPFRLELHDE 2855
Cdd:smart00112    1 SATDADSG--ENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQ-PEYTLTVEATD-GGGPPLSSTATVTITVLDV 76


                    ....*
gi 24580686    2856 NDNEP 2860
Cdd:smart00112   77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
1617-1710 8.73e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.03  E-value: 8.73e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   1617 ISDATRIGEVVAHIVAVDEDSGDNGQLTYEITGGNGEGRFRINSQTGIIELVKSLppateDVEKGGRFNLIIGAKDHGQP 1696
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPL-----DRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|....
gi 24580686   1697 ePKKSSLNLHLIVQ 1710
Cdd:pfam00028   80 -PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
616-706 2.38e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.87  E-value: 2.38e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    616 YNVSVAENEPVGRCILKVSASDPDCGVNAMVNYTI-GEGFKHLteFEVRSASGEICIAGELDFERRSSYEFPVLATDRG- 693
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlGGGPGGN--FRIDPDTGDISTTKPLDRESIGEYELTVEATDSGg 78

                           90
                   ....*....|....
gi 24580686    694 -GLSTTAMIKMQLT 706
Cdd:pfam00028   79 pPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 743-825 9.49e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.61  E-value: 9.49e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686     743 VATDPDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPdmLSVRTQPMHMLNISATDGGNLRSNADAVVFLSIIDAMQ 822
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKP--LDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 24580686     823 RPP 825
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
2758-2836 1.01e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 1.01e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24580686   2758 YEAEISELAPLRYSIAQLQAIDADQenTPNSEVVYDITSGNDEHMFTIDLVTGVLFVNNRLDYDSGAKsYELIIRACDS 2836
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGE-YELTVEATDS 76
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1409-1483 1.58e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.23  E-value: 1.58e-14
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24580686    1409 RVTYTLNPLTKDLIeaaFDIDRHSGNLVVARLLDREVQSEFRLEIRALDttASNNPQSSAITVKIEVADVNDNAP 1483
Cdd:smart00112   12 KVTYSILSGNDDGL---FSIDPETGEITTTKPLDREEQPEYTLTVEATD--GGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 420-502 1.59e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.23  E-value: 1.59e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686     420 SVHDPDSKtEYANVNVTLNGG--DGHFALTTRDNSIYLVivhLPLDREIVSNYTLSVVATDKGTPPLHASKSIFLRITDV 497
Cdd:smart00112    1 SATDADSG-ENGKVTYSILSGndDGLFSIDPETGEITTT---KPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 24580686     498 NDNPP 502
Cdd:smart00112   77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
1493-1593 2.23e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.18  E-value: 2.23e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   1493 QVSEATPVGTIIHNFTATDADTGTNGDLQYRLIryfpQLNESQeqamsLFRMDSLTGALSLQAPLDFEAVQEYLLIVQAL 1572
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL----GGGPGG-----NFRIDPDTGDISTTKPLDRESIGEYELTVEAT 74

                           90       100
                   ....*....|....*....|.
gi 24580686   1573 DQSSnvtERLQTSVTVRLRIL 1593
Cdd:pfam00028   75 DSGG---PPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2549-2641 1.26e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.26  E-value: 1.26e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 2549 EISESLSVDFDLLTVNATDADSeGNNSKVIYIIEPAQEG--FSVHPSNGVVSVNMS--RLQPAVsssgdYFVRIIAKDAG 2624
Cdd:cd11304    5 SVPENAPPGTVVLTVSATDPDS-GENGEVTYSIVSGNEDglFSIDPSTGEITTAKPldREEQSS-----YTLTVTATDGG 78

                         90       100
                 ....*....|....*....|
gi 24580686 2625 KPALKSSTLLRVQ---ANDN 2641
Cdd:cd11304   79 GPPLSSTATVTITvldVNDN 98
Cadherin pfam00028
Cadherin domain;
720-803 2.25e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.10  E-value: 2.25e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    720 YKVSLRESpkassQASSTPIVAVVATDPDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPdmLSVRTQPMHMLNISA 799
Cdd:pfam00028    1 YSASVPEN-----APVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKP--LDRESIGEYELTVEA 73


                   ....
gi 24580686    800 TDGG 803
Cdd:pfam00028   74 TDSG 77
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2450-2530 4.05e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.99  E-value: 4.05e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    2450 SANDVDTYP--ALTYRLgaestVDIENMSIFALDRYSGKLVLKRRLDYELQQEYELDVIASDAA---HEARTVLTVRVND 2524
Cdd:smart00112    1 SATDADSGEngKVTYSI-----LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGgppLSSTATVTITVLD 75


                    ....*.
gi 24580686    2525 ENDNAP 2530
Cdd:smart00112   76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
180-277 5.56e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.94  E-value: 5.56e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    180 HIEFPENTPREVKRTLLPARDLDLEPyNTQ-RYNIVSGNVNDAFRLSshrERDGVLYLDLQisgfLDRETTPGYSLLIEA 258
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGP-NGRiFYSILGGGPGGNFRID---PDTGDISTTKP----LDRESIGEYELTVEA 73

                           90
                   ....*....|....*....
gi 24580686    259 LDGGTPPLRGFMTVNITIQ 277
Cdd:pfam00028   74 TDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1724-1803 6.31e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.94  E-value: 6.31e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   1724 YRATILENVPSGSFVLQVTAKSLHGAENANLSYEIPAGVANDLFHVDWQRGIITTRGQFDRESQASYVLPVYVRDANRQS 1803
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1750-1845 9.19e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.22  E-value: 9.19e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    1750 ENANLSYEIPAGVANDLFHVDWQRGIITTRGQFDRESQASYVLPVYVRDANRQStlsssavrkqrssdsigdtsngqHFD 1829
Cdd:smart00112    9 ENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP-----------------------LSS 65

                            90
                    ....*....|....*.
gi 24580686    1830 VATIYITVGDVNDNSP 1845
Cdd:smart00112   66 TATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
2867-2960 4.18e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.63  E-value: 4.18e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   2867 YVHFLAENEPVGSSVFRAHASDLDKGPFGQLNYSIGPAPSDesswKMFRVDSESGLVTSAFVFDYEQRQRYDMELLASDM 2946
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*.
gi 24580686   2947 GGK-KASVA-VRVEIE 2960
Cdd:pfam00028   77 GGPpLSSTAtVTITVL 92
Cadherin pfam00028
Cadherin domain;
2062-2146 5.49e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.24  E-value: 5.49e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   2062 YIGQVPALIQPGQTLLKVQALDADLGANAEIVYSLNAENsaVSAKFRINPSTGALSASQSLASESGKLLHLEVVARDKGN 2141
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGG--PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78


                   ....*
gi 24580686   2142 PPQSS 2146
Cdd:pfam00028   79 PPLSS 83
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2885-2960 6.79e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.52  E-value: 6.79e-12
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24580686    2885 HASDLDKGPFGQLNYSIgpapSDESSWKMFRVDSESGLVTSAFVFDYEQRQRYDMELLASDMGGKKASVAVRVEIE 2960
Cdd:smart00112    1 SATDADSGENGKVTYSI----LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72
Cadherin pfam00028
Cadherin domain;
406-484 1.28e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.09  E-value: 1.28e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    406 ISESAQPGEFVARISVHDPDsktEYANVNVT---LNGG-DGHFALTTRDNSIYLVIvhlPLDREIVSNYTLSVVATDKGT 481
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPD---LGPNGRIFysiLGGGpGGNFRIDPDTGDISTTK---PLDRESIGEYELTVEATDSGG 78


                   ...
gi 24580686    482 PPL 484
Cdd:pfam00028   79 PPL 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2080-2154 5.43e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.21  E-value: 5.43e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24580686    2080 QALDADLGANAEIVYSLNAENsaVSAKFRINPSTGALSASQSLASESGKLLHLEVVARDKGNPPQSSLGLIELLI 2154
Cdd:smart00112    1 SATDADSGENGKVTYSILSGN--DDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2985-3071 2.12e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.02  E-value: 2.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 2985 PQGYVVGQVTATDSDSGPDGRVVYQLSA--PHSHFKVNRSSGAVLIKRklKLDgdgdgnlYMDGRDISLVISASSGRHNS 3062
Cdd:cd11304   11 PPGTVVLTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPSTGEITTAK--PLD-------REEQSSYTLTVTATDGGGPP 81


                 ....*....
gi 24580686 3063 LSSMAVVEI 3071
Cdd:cd11304   82 LSSTATVTI 90
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2652-2748 2.56e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 59.63  E-value: 2.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 2652 QYRAQISEAAPLGSVVLQLGqdALDQ--------SLAIIAGNEESAFEL-LQSKAIVLVKPLDRERNDLYKLRLVLSHPH 2722
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVS--ATDPdsgengevTYSIVSGNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                         90       100
                 ....*....|....*....|....*.
gi 24580686 2723 GPPlisslnSSSGISVIITILDANDN 2748
Cdd:cd11304   79 GPP------LSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2434-2523 3.74e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.15  E-value: 3.74e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   2434 VTVSEATELGAVITSISANDVDTYPA--LTYRLgaeSTVDIENMsiFALDRYSGKLVLKRRLDYELQQEYELDVIASDAA 2511
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNgrIFYSI---LGGGPGGN--FRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|...
gi 24580686   2512 HEART-VLTVRVN 2523
Cdd:pfam00028   78 GPPLSsTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 111-172 5.29e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.43  E-value: 5.29e-09
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24580686     111 YIIVAEaGVETDLAIDRATGEIRTKVKLDRETRASYSLVAI-------PLSGrNIRVLVTVKDENDNAP 172
Cdd:smart00112   15 YSILSG-NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEatdgggpPLSS-TATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 84-170 1.11e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 55.01  E-value: 1.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   84 LEVFEGVAVDYQIGYIG--DfggIDSGPP----YIIVAEAGVETdLAIDRATGEIRTKVKLDRETRASYSLVAI------ 151
Cdd:cd11304    4 VSVPENAPPGTVVLTVSatD---PDSGENgevtYSIVSGNEDGL-FSIDPSTGEITTAKPLDREEQSSYTLTVTatdggg 79

                         90       100
                 ....*....|....*....|
gi 24580686  152 -PLSGRnIRVLVTVKDENDN 170
Cdd:cd11304   80 pPLSST-ATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1371-1475 1.46e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 54.61  E-value: 1.46e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   1371 VFRVREDAALGHVVGSISPIerPADVVRNSveesfedlRVTYTLnplTKDLIEAAFDIDRHSGNLVVARLLDREVQSEFR 1450
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTAT--DPDLGPNG--------RIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYE 68

                           90       100
                   ....*....|....*....|....*
gi 24580686   1451 LEIRALDttASNNPQSSAITVKIEV 1475
Cdd:pfam00028   69 LTVEATD--SGGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
2549-2637 5.74e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.99  E-value: 5.74e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   2549 EISESLSVDFDLLTVNATDADsEGNNSKVIY-IIEPAQEG-FSVHPSNGVVSVNMsRLQPAvsSSGDYFVRIIAKDAGKP 2626
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPD-LGPNGRIFYsILGGGPGGnFRIDPDTGDISTTK-PLDRE--SIGEYELTVEATDSGGP 79

                           90
                   ....*....|.
gi 24580686   2627 ALKSSTLLRVQ 2637
Cdd:pfam00028   80 PLSSTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2564-2641 1.71e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 48.50  E-value: 1.71e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    2564 NATDADSeGNNSKVIYIIEPAQEG--FSVHPSNGVVSVNMS--RLQPAVsssgdYFVRIIAKDAGKPALKSSTLLRVQ-- 2637
Cdd:smart00112    1 SATDADS-GENGKVTYSILSGNDDglFSIDPETGEITTTKPldREEQPE-----YTLTVEATDGGGPPLSSTATVTITvl 74


                    ....*
gi 24580686    2638 -ANDN 2641
Cdd:smart00112   75 dVNDN 79
Cadherin pfam00028
Cadherin domain;
2171-2232 8.91e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 46.52  E-value: 8.91e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24580686   2171 YRVMLKENSPSGTRLLQVVALRSD-GRRQKVQFSFGAGNEDGILSLDSLSGEIRVNKPhlLDY 2232
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDlGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKP--LDR 61
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2681-2750 8.39e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 43.49  E-value: 8.39e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24580686    2681 IIAGNEESAFEL-LQSKAIVLVKPLDRERNDLYKLRLVLSHPHGPPlisslnSSSGISVIITILDANDNFP 2750
Cdd:smart00112   17 ILSGNDDGLFSIdPETGEITTTKPLDREEQPEYTLTVEATDGGGPP------LSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
2985-3071 1.28e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.44  E-value: 1.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   2985 PQGYVVGQVTATDSDSGPDGRVVYQLSAPHS--HFKVNRSSGAVLIKRKLKldgdgdgnlYMDGRDISLVISASSGRHNS 3062
Cdd:pfam00028   10 PVGTEVLTVTATDPDLGPNGRIFYSILGGGPggNFRIDPDTGDISTTKPLD---------RESIGEYELTVEATDSGGPP 80


                   ....*....
gi 24580686   3063 LSSMAVVEI 3071
Cdd:pfam00028   81 LSSTATVTI 89
Cadherin pfam00028
Cadherin domain;
2653-2725 2.34e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 42.67  E-value: 2.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   2653 YRAQISEAAPLGSVVLQLGQDALDQSL------AIIAGNEESAFELLQSKA-IVLVKPLDRERNDLYKLRLVLSHPHGPP 2725
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPngrifySILGGGPGGNFRIDPDTGdISTTKPLDRESIGEYELTVEATDSGGPP 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2994-3071 4.99e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.18  E-value: 4.99e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    2994 TATDSDSGPDGRVVYQLS--APHSHFKVNRSSGAVLIKRKLKldgdgdgnlYMDGRDISLVISASSGRHNSLSSMAVVEI 3071
Cdd:smart00112    1 SATDADSGENGKVTYSILsgNDDGLFSIDPETGEITTTKPLD---------REEQPEYTLTVEATDGGGPPLSSTATVTI 71
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2194-2320 2.09e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 39.64  E-value: 2.09e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    2194 DGRRQKVQFSFGAGNEDGILSLDSLSGEIRVNKPhlLDYDrfstpsmsalsrgralhyeeeidesseedpnnstrsqral 2273
Cdd:smart00112    7 SGENGKVTYSILSGNDDGLFSIDPETGEITTTKP--LDRE---------------------------------------- 44

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*..
gi 24580686    2274 tsssfaltnsQPNEIRVVLVARTADAPFLASYAELVIELEDENDNSP 2320
Cdd:smart00112   45 ----------EQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1158-1252 1.42e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 128.97  E-value: 1.42e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 1158 YEFRIEENLRRGSVVGVVTASDLDLGENAAIRYSLLPINSS--FQVHPVTGEISTREPLDRELRELYDLVVEARDQGTPV 1235
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                         90
                 ....*....|....*..
gi 24580686 1236 RSARVPVRIHVSDVNDN 1252
Cdd:cd11304   82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 291-389 3.37e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.12  E-value: 3.37e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686  291 YFATVPENATVGTSVLQVYASDTDADENGLVEYAInrRQSDKEQMFRIDPRTGAIYINKALDFETKELHELVVVAKDHGE 370
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 24580686  371 QPLETTAFVSIRVTDVNDN 389
Cdd:cd11304   80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 509-607 7.41e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.96  E-value: 7.41e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686  509 YHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLaeTPETHAQWFQIDPQTGLITTRSHIDCETEPVPQLTVVARDGGV 588
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 24580686  589 PPLSSTATVLVTIHDVNDN 607
Cdd:cd11304   80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1853-1948 1.55e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.19  E-value: 1.55e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 1853 YGLSVPENSEPG-VIHTVVASDLDEGPNADLIYSITGGNLGNKFSIDSSSGELS-ARPLDREQHSRYTLQIQASDRGQPk 1930
Cdd:cd11304    2 YEVSVPENAPPGtVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITtAKPLDREEQSSYTLTVTATDGGGP- 80

                         90
                 ....*....|....*...
gi 24580686 1931 SRQGHCNITIFVEDQNDN 1948
Cdd:cd11304   81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1040-1149 1.84e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.81  E-value: 1.84e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 1040 EYSVNVSESRSINAQIIQVNASDLDTGNNARITYrivdagvdnvtnSISSSDVSQHFGIFPNSGWIYLRAPLDRETRDRY 1119
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTY------------SIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSY 68

                         90       100       110
                 ....*....|....*....|....*....|
gi 24580686 1120 QLTVLATDNGTPAAHAKTRVIVRVLDANDN 1149
Cdd:cd11304   69 TLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1263-1361 3.43e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.04  E-value: 3.43e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 1263 VVSVREEQPPGTEVVRVRAVDRDHGQNASITYSIVKGrdsDGHGLFSIDPTSGVIRTRVVLDHEERSIYRLGVAASDGGN 1342
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 24580686 1343 PPRETVRMLRVEVLDLNDN 1361
Cdd:cd11304   80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1957-2053 3.71e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.04  E-value: 3.71e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 1957 YTGSVQEDAPLGTSVVQISAVDADLGVNARLVYSLANETQWQ-FAIDGQSGLITTVGKLDRELQASYNFMVLATDGGRyE 2035
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG-P 80

                         90
                 ....*....|....*...
gi 24580686 2036 VRSATVPVQINVLDINDN 2053
Cdd:cd11304   81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2326-2424 1.15e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.50  E-value: 1.15e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 2326 QFVATVSEGNNKGTFVAQVHAFDSDAGSNARLRYHIVDGNHDNAFVIEPAfSGIVRTNIVLDREIRDIYKLKIIATDEGV 2405
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPS-TGEITTAKPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 24580686 2406 PQMTGTATIRVQIVDVNDN 2424
Cdd:cd11304   80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 937-1032 1.91e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.03  E-value: 1.91e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686  937 RISVPESAELGAPLYAAHAHDKDSGSSGQVTYSLVKESGKGLFAIDARSGHLILSQHLDYESSQRHTLIVTATDGGVPSL 1016
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                         90
                 ....*....|....*.
gi 24580686 1017 STNLTILVDVQDVNDN 1032
Cdd:cd11304   83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 832-927 4.63e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.48  E-value: 4.63e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686  832 YNYYVKEDIPRGTVVGSVIAASGDVAHRSPVRYSIYSGDPDGYFSIETNSGNIRIAKPLDHEAKSQVLLNIQAT-LGEPP 910
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATdGGGPP 81

                         90
                 ....*....|....*..
gi 24580686  911 VYGHTQVNIEVEDVNDN 927
Cdd:cd11304   82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 954-1034 1.32e-26

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 105.51  E-value: 1.32e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686     954 HAHDKDSGSSGQVTYSLVKESGKGLFAIDARSGHLILSQHLDYESSQRHTLIVTATDGGVPSLSTNLTILVDVQDVNDNP 1033
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 24580686    1034 P 1034
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
1158-1246 4.33e-26

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 104.30  E-value: 4.33e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   1158 YEFRIEENLRRGSVVGVVTASDLDLGENAAIRYSLL--PINSSFQVHPVTGEISTREPLDRELRELYDLVVEARDQGTPV 1235
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 24580686   1236 RSARVPVRIHV 1246
Cdd:pfam00028   81 LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2345-2426 1.65e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 102.43  E-value: 1.65e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    2345 HAFDSDAGSNARLRYHIVDGNHDNAFVIEPaFSGIVRTNIVLDREIRDIYKLKIIATDEGVPQMTGTATIRVQIVDVNDN 2424
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDP-ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 24580686    2425 QP 2426
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 616-711 1.82e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.78  E-value: 1.82e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686  616 YNVSVAENEPVGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTeFEVRSASGEICIAGELDFERRSSYEFPVLATDRGG- 694
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL-FSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                         90
                 ....*....|....*...
gi 24580686  695 -LSTTAMIKMQLTDVNDN 711
Cdd:cd11304   81 pLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 528-609 2.34e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 102.04  E-value: 2.34e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686     528 AHDRDEGLNSALTYSLaeTPETHAQWFQIDPQTGLITTRSHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDN 607
Cdd:smart00112    2 ATDADSGENGKVTYSI--LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 24580686     608 EP 609
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1176-1254 3.29e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 101.66  E-value: 3.29e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    1176 TASDLDLGENAAIRYSLLP--INSSFQVHPVTGEISTREPLDRELRELYDLVVEARDQGTPVRSARVPVRIHVSDVNDNA 1253
Cdd:smart00112    1 SATDADSGENGKVTYSILSgnDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 24580686    1254 P 1254
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1870-1950 3.63e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 101.27  E-value: 3.63e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    1870 VASDLDEGPNADLIYSITGGNLGNKFSIDSSSGELS-ARPLDREQHSRYTLQIQASDRGQPkSRQGHCNITIFVEDQNDN 1948
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITtTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLDVNDN 79


                    ..
gi 24580686    1949 AP 1950
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
1263-1356 7.48e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 100.84  E-value: 7.48e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   1263 VVSVREEQPPGTEVVRVRAVDRDHGQNASITYSIVKGRDSdghGLFSIDPTSGVIRTRVVLDHEERSIYRLGVAASDGGN 1342
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPG---GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 24580686   1343 PPRETVRMLRVEVL 1356
Cdd:pfam00028   79 PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
509-602 1.88e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 99.68  E-value: 1.88e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    509 YHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLAETPEthAQWFQIDPQTGLITTRSHIDCETEPVPQLTVVARDGGV 588
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGP--GGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 24580686    589 PPLSSTATVLVTIH 602
Cdd:pfam00028   79 PPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1489-1598 3.78e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.31  E-value: 3.78e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 1489 PIDLQVSEATPVGTIIHNFTATDADTGTNGDLQYRLiryfpqlneSQEQAMSLFRMDSLTGALSLQAPLDFEAVQEYLLI 1568
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI---------VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLT 71

                         90       100       110
                 ....*....|....*....|....*....|
gi 24580686 1569 VQALDQSSNvteRLQTSVTVRLRILDANDH 1598
Cdd:cd11304   72 VTATDGGGP---PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1280-1363 1.07e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 97.42  E-value: 1.07e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    1280 RAVDRDHGQNASITYSIVKGrdsDGHGLFSIDPTSGVIRTRVVLDHEERSIYRLGVAASDGGNPPRETVRMLRVEVLDLN 1359
Cdd:smart00112    1 SATDADSGENGKVTYSILSG---NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 24580686    1360 DNRP 1363
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1059-1151 2.80e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.88  E-value: 2.80e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    1059 NASDLDTGNNARITYRIVDAGVDNvtnsisssdvsqHFGIFPNSGWIYLRAPLDRETRDRYQLTVLATDNGTPAAHAKTR 1138
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDG------------LFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTAT 68

                            90
                    ....*....|...
gi 24580686    1139 VIVRVLDANDNDP 1151
Cdd:smart00112   69 VTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 310-391 5.65e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.11  E-value: 5.65e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686     310 ASDTDADENGLVEYAINrrQSDKEQMFRIDPRTGAIYINKALDFETKELHELVVVAKDHGEQPLETTAFVSIRVTDVNDN 389
Cdd:smart00112    2 ATDADSGENGKVTYSIL--SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 24580686     390 QP 391
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
291-384 7.15e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.45  E-value: 7.15e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    291 YFATVPENATVGTSVLQVYASDTDADENGLVEYAInrRQSDKEQMFRIDPRTGAIYINKALDFETKELHELVVVAKDHGE 370
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI--LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 24580686    371 QPLETTAFVSIRVT 384
Cdd:pfam00028   79 PPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 178-282 7.93e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 7.93e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686  178 SMHIEFPENTPREVKRTLLPARDLDLEPYNTQRYNIVSGNVNDAFRLSSHrerDGVLYLdlqiSGFLDRETTPGYSLLIE 257
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPS---TGEITT----AKPLDREEQSSYTLTVT 73

                         90       100
                 ....*....|....*....|....*
gi 24580686  258 ALDGGTPPLRGFMTVNITIQDVNDN 282
Cdd:cd11304   74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1041-1144 8.27e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.06  E-value: 8.27e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   1041 YSVNVSESRSINAQIIQVNASDLDTGNNARITYrivdagvdnvtnSISSSDVSQHFGIFPNSGWIYLRAPLDRETRDRYQ 1120
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFY------------SILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYE 68

                           90       100
                   ....*....|....*....|....
gi 24580686   1121 LTVLATDNGTPAAHAKTRVIVRVL 1144
Cdd:pfam00028   69 LTVEATDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
2327-2418 1.14e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 94.67  E-value: 1.14e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   2327 FVATVSEGNNKGTFVAQVHAFDSDAGSNARLRYHIVDGNHDNAFVIEPAfSGIVRTNIVLDREIRDIYKLKIIATDEGVP 2406
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPD-TGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|..
gi 24580686   2407 QMTGTATIRVQI 2418
Cdd:pfam00028   80 PLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1723-1843 5.76e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.76  E-value: 5.76e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 1723 VYRATILENVPSGSFVLQVTAKSLHGAENANLSYEIPAGVANDLFHVDWQRGIITTRGQFDRESQASYVLPVYVRDANRQ 1802
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 24580686 1803 StLSSSavrkqrssdsigdtsngqhfdvATIYITVGDVNDN 1843
Cdd:cd11304   81 P-LSST----------------------ATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1975-2055 9.13e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 91.64  E-value: 9.13e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    1975 SAVDADLGVNARLVYSLANETQWQ-FAIDGQSGLITTVGKLDRELQASYNFMVLATDGGRYEvRSATVPVQINVLDINDN 2053
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGlFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP-LSSTATVTITVLDVNDN 79


                    ..
gi 24580686    2054 RP 2055
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2758-2858 1.17e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 1.17e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 2758 YEAEISELAPLRYSIAQLQAIDADQEntPNSEVVYDITSGNDEHMFTIDLVTGVLFVNNRLDYDSGAkSYELIIRACDsH 2837
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQS-SYTLTVTATD-G 77

                         90       100
                 ....*....|....*....|.
gi 24580686 2838 HQRPLCSLQPFRLELHDENDN 2858
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1856-1940 1.50e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 91.59  E-value: 1.50e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   1856 SVPENSEPGV-IHTVVASDLDEGPNADLIYSITGGNLGNKFSIDSSSGELS-ARPLDREQHSRYTLQIQASDRG-QPKSR 1932
Cdd:pfam00028    4 SVPENAPVGTeVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDIStTKPLDRESIGEYELTVEATDSGgPPLSS 83


                   ....*...
gi 24580686   1933 QGHCNITI 1940
Cdd:pfam00028   84 TATVTITV 91
Cadherin pfam00028
Cadherin domain;
1957-2048 7.33e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.67  E-value: 7.33e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   1957 YTGSVQEDAPLGTSVVQISAVDADLGVNARLVYSLA--NETQWqFAIDGQSGLITTVGKLDRELQASYNFMVLATDGGRY 2034
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGN-FRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|....
gi 24580686   2035 eVRSATVPVQINVL 2048
Cdd:pfam00028   80 -PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1614-1710 1.85e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.52  E-value: 1.85e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 1614 SLFISDATRIGEVVAHIVAVDEDSGDNGQLTYEITGGNGEGRFRINSQTGIIELVKSLppateDVEKGGRFNLIIGAKDH 1693
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPL-----DREEQSSYTLTVTATDG 77

                         90
                 ....*....|....*..
gi 24580686 1694 GQPePKKSSLNLHLIVQ 1710
Cdd:cd11304   78 GGP-PLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 719-820 3.16e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.14  E-value: 3.16e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686  719 EYKVSLRESpkassQASSTPIVAVVATDPDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPdmLSVRTQPMHMLNIS 798
Cdd:cd11304    1 SYEVSVPEN-----APPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKP--LDREEQSSYTLTVT 73

                         90       100
                 ....*....|....*....|..
gi 24580686  799 ATDGGNLRSNADAVVFLSIIDA 820
Cdd:cd11304   74 ATDGGGPPLSSTATVTITVLDV 95
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 406-500 1.82e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.83  E-value: 1.82e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686  406 ISESAQPGEFVARISVHDPDSkTEYANVNVTLNGGD--GHFALTTRDNSIYLVivhLPLDREIVSNYTLSVVATDKGTPP 483
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDS-GENGEVTYSIVSGNedGLFSIDPSTGEITTA---KPLDREEQSSYTLTVTATDGGGPP 81

                         90
                 ....*....|....*..
gi 24580686  484 LHASKSIFLRITDVNDN 500
Cdd:cd11304   82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 855-929 6.78e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.55  E-value: 6.78e-19
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24580686     855 DVAHRSPVRYSIYSGDPDGYFSIETNSGNIRIAKPLDHEAKSQVLLNIQAT-LGEPPVYGHTQVNIEVEDVNDNAP 929
Cdd:smart00112    6 DSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATdGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2061-2154 7.69e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 7.69e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 2061 PYIGQVPALIQPGQTLLKVQALDADLGANAEIVYSLNAENSavSAKFRINPSTGALSASQSLASESGKLLHLEVVARDKG 2140
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE--DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                         90
                 ....*....|....
gi 24580686 2141 NPPQSSLGLIELLI 2154
Cdd:cd11304   79 GPPLSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2434-2528 1.43e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.13  E-value: 1.43e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 2434 VTVSEATELGAVITSISANDVDTYPA--LTYRLgaestVDIENMSIFALDRYSGKLVLKRRLDYELQQEYELDVIASDA- 2510
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENgeVTYSI-----VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGg 78

                         90       100
                 ....*....|....*....|
gi 24580686 2511 --AHEARTVLTVRVNDENDN 2528
Cdd:cd11304   79 gpPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
938-1027 4.68e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.58  E-value: 4.68e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    938 ISVPESAELGAPLYAAHAHDKDSGSSGQVTYSLVKESGKGLFAIDARSGHLILSQHLDYESSQRHTLIVTATDGGVPSLS 1017
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82

                           90
                   ....*....|
gi 24580686   1018 TNLTILVDVQ 1027
Cdd:pfam00028   83 STATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 634-713 6.00e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.86  E-value: 6.00e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686     634 SASDPDCGVNAMVNYTIGEGFkHLTEFEVRSASGEICIAGELDFERRSSYEFPVLATDRGG--LSTTAMIKMQLTDVNDN 711
Cdd:smart00112    1 SATDADSGENGKVTYSILSGN-DDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDN 79


                    ..
gi 24580686     712 RP 713
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 198-284 7.01e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.86  E-value: 7.01e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686     198 ARDLDLEPYNTQRYNIVSGNVNDAFRLSSHrerDGVLYLDLQisgfLDRETTPGYSLLIEALDGGTPPLRGFMTVNITIQ 277
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPE---TGEITTTKP----LDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                    ....*..
gi 24580686     278 DVNDNQP 284
Cdd:smart00112   75 DVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2866-2960 9.45e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.82  E-value: 9.45e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 2866 EYVHFLAENEPVGSSVFRAHASDLDKGPFGQLNYSIgpapSDESSWKMFRVDSESGLVTSAFVFDYEQRQRYDMELLASD 2945
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI----VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                         90
                 ....*....|....*..
gi 24580686 2946 MGG--KKASVAVRVEIE 2960
Cdd:cd11304   77 GGGppLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1631-1717 1.07e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 1.07e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    1631 VAVDEDSGDNGQLTYEITGGNGEGRFRINSQTGIIELVKSLppateDVEKGGRFNLIIGAKDHGQPePKKSSLNLHLIVQ 1710
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPL-----DREEQPEYTLTVEATDGGGP-PLSSTATVTITVL 74


                    ....*..
gi 24580686    1711 GSHNNPP 1717
Cdd:smart00112   75 DVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1508-1600 1.41e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 79.70  E-value: 1.41e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    1508 TATDADTGTNGDLQYRLiryfpqlneSQEQAMSLFRMDSLTGALSLQAPLDFEAVQEYLLIVQALDQSSNvteRLQTSVT 1587
Cdd:smart00112    1 SATDADSGENGKVTYSI---------LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP---PLSSTAT 68

                            90
                    ....*....|...
gi 24580686    1588 VRLRILDANDHAP 1600
Cdd:smart00112   69 VTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1369-1481 1.04e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.12  E-value: 1.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 1369 SLVFRVREDAALGHVVGSISPIerPADVVRNSveesfedlRVTYTLnplTKDLIEAAFDIDRHSGNLVVARLLDREVQSE 1448
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSAT--DPDSGENG--------EVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQSS 67

                         90       100       110
                 ....*....|....*....|....*....|...
gi 24580686 1449 FRLEIRALDttASNNPQSSAITVKIEVADVNDN 1481
Cdd:cd11304   68 YTLTVTATD--GGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
832-922 1.97e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.96  E-value: 1.97e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    832 YNYYVKEDIPRGTVVGSVIAASGDVAHRSPVRYSIYSGDPDGYFSIETNSGNIRIAKPLDHEAKSQVLLNIQAT-LGEPP 910
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATdSGGPP 80

                           90
                   ....*....|..
gi 24580686    911 VYGHTQVNIEVE 922
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2776-2860 7.53e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.08  E-value: 7.53e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    2776 QAIDADQEntPNSEVVYDITSGNDEHMFTIDLVTGVLFVNNRLDYDSGaKSYELIIRACDsHHQRPLCSLQPFRLELHDE 2855
Cdd:smart00112    1 SATDADSG--ENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQ-PEYTLTVEATD-GGGPPLSSTATVTITVLDV 76


                    ....*
gi 24580686    2856 NDNEP 2860
Cdd:smart00112   77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
1617-1710 8.73e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.03  E-value: 8.73e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   1617 ISDATRIGEVVAHIVAVDEDSGDNGQLTYEITGGNGEGRFRINSQTGIIELVKSLppateDVEKGGRFNLIIGAKDHGQP 1696
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPL-----DRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|....
gi 24580686   1697 ePKKSSLNLHLIVQ 1710
Cdd:pfam00028   80 -PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
616-706 2.38e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.87  E-value: 2.38e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    616 YNVSVAENEPVGRCILKVSASDPDCGVNAMVNYTI-GEGFKHLteFEVRSASGEICIAGELDFERRSSYEFPVLATDRG- 693
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlGGGPGGN--FRIDPDTGDISTTKPLDRESIGEYELTVEATDSGg 78

                           90
                   ....*....|....
gi 24580686    694 -GLSTTAMIKMQLT 706
Cdd:pfam00028   79 pPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 743-825 9.49e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.61  E-value: 9.49e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686     743 VATDPDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPdmLSVRTQPMHMLNISATDGGNLRSNADAVVFLSIIDAMQ 822
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKP--LDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 24580686     823 RPP 825
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
2758-2836 1.01e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 1.01e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24580686   2758 YEAEISELAPLRYSIAQLQAIDADQenTPNSEVVYDITSGNDEHMFTIDLVTGVLFVNNRLDYDSGAKsYELIIRACDS 2836
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGE-YELTVEATDS 76
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1409-1483 1.58e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.23  E-value: 1.58e-14
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24580686    1409 RVTYTLNPLTKDLIeaaFDIDRHSGNLVVARLLDREVQSEFRLEIRALDttASNNPQSSAITVKIEVADVNDNAP 1483
Cdd:smart00112   12 KVTYSILSGNDDGL---FSIDPETGEITTTKPLDREEQPEYTLTVEATD--GGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 420-502 1.59e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.23  E-value: 1.59e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686     420 SVHDPDSKtEYANVNVTLNGG--DGHFALTTRDNSIYLVivhLPLDREIVSNYTLSVVATDKGTPPLHASKSIFLRITDV 497
Cdd:smart00112    1 SATDADSG-ENGKVTYSILSGndDGLFSIDPETGEITTT---KPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 24580686     498 NDNPP 502
Cdd:smart00112   77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
1493-1593 2.23e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.18  E-value: 2.23e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   1493 QVSEATPVGTIIHNFTATDADTGTNGDLQYRLIryfpQLNESQeqamsLFRMDSLTGALSLQAPLDFEAVQEYLLIVQAL 1572
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL----GGGPGG-----NFRIDPDTGDISTTKPLDRESIGEYELTVEAT 74

                           90       100
                   ....*....|....*....|.
gi 24580686   1573 DQSSnvtERLQTSVTVRLRIL 1593
Cdd:pfam00028   75 DSGG---PPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2549-2641 1.26e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.26  E-value: 1.26e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 2549 EISESLSVDFDLLTVNATDADSeGNNSKVIYIIEPAQEG--FSVHPSNGVVSVNMS--RLQPAVsssgdYFVRIIAKDAG 2624
Cdd:cd11304    5 SVPENAPPGTVVLTVSATDPDS-GENGEVTYSIVSGNEDglFSIDPSTGEITTAKPldREEQSS-----YTLTVTATDGG 78

                         90       100
                 ....*....|....*....|
gi 24580686 2625 KPALKSSTLLRVQ---ANDN 2641
Cdd:cd11304   79 GPPLSSTATVTITvldVNDN 98
Cadherin pfam00028
Cadherin domain;
720-803 2.25e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.10  E-value: 2.25e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    720 YKVSLRESpkassQASSTPIVAVVATDPDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPdmLSVRTQPMHMLNISA 799
Cdd:pfam00028    1 YSASVPEN-----APVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKP--LDRESIGEYELTVEA 73


                   ....
gi 24580686    800 TDGG 803
Cdd:pfam00028   74 TDSG 77
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2450-2530 4.05e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.99  E-value: 4.05e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    2450 SANDVDTYP--ALTYRLgaestVDIENMSIFALDRYSGKLVLKRRLDYELQQEYELDVIASDAA---HEARTVLTVRVND 2524
Cdd:smart00112    1 SATDADSGEngKVTYSI-----LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGgppLSSTATVTITVLD 75


                    ....*.
gi 24580686    2525 ENDNAP 2530
Cdd:smart00112   76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
180-277 5.56e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.94  E-value: 5.56e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    180 HIEFPENTPREVKRTLLPARDLDLEPyNTQ-RYNIVSGNVNDAFRLSshrERDGVLYLDLQisgfLDRETTPGYSLLIEA 258
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGP-NGRiFYSILGGGPGGNFRID---PDTGDISTTKP----LDRESIGEYELTVEA 73

                           90
                   ....*....|....*....
gi 24580686    259 LDGGTPPLRGFMTVNITIQ 277
Cdd:pfam00028   74 TDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1724-1803 6.31e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.94  E-value: 6.31e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   1724 YRATILENVPSGSFVLQVTAKSLHGAENANLSYEIPAGVANDLFHVDWQRGIITTRGQFDRESQASYVLPVYVRDANRQS 1803
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1750-1845 9.19e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.22  E-value: 9.19e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    1750 ENANLSYEIPAGVANDLFHVDWQRGIITTRGQFDRESQASYVLPVYVRDANRQStlsssavrkqrssdsigdtsngqHFD 1829
Cdd:smart00112    9 ENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP-----------------------LSS 65

                            90
                    ....*....|....*.
gi 24580686    1830 VATIYITVGDVNDNSP 1845
Cdd:smart00112   66 TATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
2867-2960 4.18e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.63  E-value: 4.18e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   2867 YVHFLAENEPVGSSVFRAHASDLDKGPFGQLNYSIGPAPSDesswKMFRVDSESGLVTSAFVFDYEQRQRYDMELLASDM 2946
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*.
gi 24580686   2947 GGK-KASVA-VRVEIE 2960
Cdd:pfam00028   77 GGPpLSSTAtVTITVL 92
Cadherin pfam00028
Cadherin domain;
2062-2146 5.49e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.24  E-value: 5.49e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   2062 YIGQVPALIQPGQTLLKVQALDADLGANAEIVYSLNAENsaVSAKFRINPSTGALSASQSLASESGKLLHLEVVARDKGN 2141
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGG--PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78


                   ....*
gi 24580686   2142 PPQSS 2146
Cdd:pfam00028   79 PPLSS 83
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2885-2960 6.79e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.52  E-value: 6.79e-12
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24580686    2885 HASDLDKGPFGQLNYSIgpapSDESSWKMFRVDSESGLVTSAFVFDYEQRQRYDMELLASDMGGKKASVAVRVEIE 2960
Cdd:smart00112    1 SATDADSGENGKVTYSI----LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72
Cadherin pfam00028
Cadherin domain;
406-484 1.28e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.09  E-value: 1.28e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    406 ISESAQPGEFVARISVHDPDsktEYANVNVT---LNGG-DGHFALTTRDNSIYLVIvhlPLDREIVSNYTLSVVATDKGT 481
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPD---LGPNGRIFysiLGGGpGGNFRIDPDTGDISTTK---PLDRESIGEYELTVEATDSGG 78


                   ...
gi 24580686    482 PPL 484
Cdd:pfam00028   79 PPL 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2080-2154 5.43e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.21  E-value: 5.43e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24580686    2080 QALDADLGANAEIVYSLNAENsaVSAKFRINPSTGALSASQSLASESGKLLHLEVVARDKGNPPQSSLGLIELLI 2154
Cdd:smart00112    1 SATDADSGENGKVTYSILSGN--DDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2985-3071 2.12e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.02  E-value: 2.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 2985 PQGYVVGQVTATDSDSGPDGRVVYQLSA--PHSHFKVNRSSGAVLIKRklKLDgdgdgnlYMDGRDISLVISASSGRHNS 3062
Cdd:cd11304   11 PPGTVVLTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPSTGEITTAK--PLD-------REEQSSYTLTVTATDGGGPP 81


                 ....*....
gi 24580686 3063 LSSMAVVEI 3071
Cdd:cd11304   82 LSSTATVTI 90
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2652-2748 2.56e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 59.63  E-value: 2.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686 2652 QYRAQISEAAPLGSVVLQLGqdALDQ--------SLAIIAGNEESAFEL-LQSKAIVLVKPLDRERNDLYKLRLVLSHPH 2722
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVS--ATDPdsgengevTYSIVSGNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                         90       100
                 ....*....|....*....|....*.
gi 24580686 2723 GPPlisslnSSSGISVIITILDANDN 2748
Cdd:cd11304   79 GPP------LSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2434-2523 3.74e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.15  E-value: 3.74e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   2434 VTVSEATELGAVITSISANDVDTYPA--LTYRLgaeSTVDIENMsiFALDRYSGKLVLKRRLDYELQQEYELDVIASDAA 2511
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNgrIFYSI---LGGGPGGN--FRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|...
gi 24580686   2512 HEART-VLTVRVN 2523
Cdd:pfam00028   78 GPPLSsTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 111-172 5.29e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.43  E-value: 5.29e-09
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24580686     111 YIIVAEaGVETDLAIDRATGEIRTKVKLDRETRASYSLVAI-------PLSGrNIRVLVTVKDENDNAP 172
Cdd:smart00112   15 YSILSG-NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEatdgggpPLSS-TATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 84-170 1.11e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 55.01  E-value: 1.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   84 LEVFEGVAVDYQIGYIG--DfggIDSGPP----YIIVAEAGVETdLAIDRATGEIRTKVKLDRETRASYSLVAI------ 151
Cdd:cd11304    4 VSVPENAPPGTVVLTVSatD---PDSGENgevtYSIVSGNEDGL-FSIDPSTGEITTAKPLDREEQSSYTLTVTatdggg 79

                         90       100
                 ....*....|....*....|
gi 24580686  152 -PLSGRnIRVLVTVKDENDN 170
Cdd:cd11304   80 pPLSST-ATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1371-1475 1.46e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 54.61  E-value: 1.46e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   1371 VFRVREDAALGHVVGSISPIerPADVVRNSveesfedlRVTYTLnplTKDLIEAAFDIDRHSGNLVVARLLDREVQSEFR 1450
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTAT--DPDLGPNG--------RIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYE 68

                           90       100
                   ....*....|....*....|....*
gi 24580686   1451 LEIRALDttASNNPQSSAITVKIEV 1475
Cdd:pfam00028   69 LTVEATD--SGGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
2549-2637 5.74e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.99  E-value: 5.74e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   2549 EISESLSVDFDLLTVNATDADsEGNNSKVIY-IIEPAQEG-FSVHPSNGVVSVNMsRLQPAvsSSGDYFVRIIAKDAGKP 2626
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPD-LGPNGRIFYsILGGGPGGnFRIDPDTGDISTTK-PLDRE--SIGEYELTVEATDSGGP 79

                           90
                   ....*....|.
gi 24580686   2627 ALKSSTLLRVQ 2637
Cdd:pfam00028   80 PLSSTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2564-2641 1.71e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 48.50  E-value: 1.71e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    2564 NATDADSeGNNSKVIYIIEPAQEG--FSVHPSNGVVSVNMS--RLQPAVsssgdYFVRIIAKDAGKPALKSSTLLRVQ-- 2637
Cdd:smart00112    1 SATDADS-GENGKVTYSILSGNDDglFSIDPETGEITTTKPldREEQPE-----YTLTVEATDGGGPPLSSTATVTITvl 74


                    ....*
gi 24580686    2638 -ANDN 2641
Cdd:smart00112   75 dVNDN 79
Cadherin pfam00028
Cadherin domain;
2171-2232 8.91e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 46.52  E-value: 8.91e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24580686   2171 YRVMLKENSPSGTRLLQVVALRSD-GRRQKVQFSFGAGNEDGILSLDSLSGEIRVNKPhlLDY 2232
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDlGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKP--LDR 61
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2681-2750 8.39e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 43.49  E-value: 8.39e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24580686    2681 IIAGNEESAFEL-LQSKAIVLVKPLDRERNDLYKLRLVLSHPHGPPlisslnSSSGISVIITILDANDNFP 2750
Cdd:smart00112   17 ILSGNDDGLFSIdPETGEITTTKPLDREEQPEYTLTVEATDGGGPP------LSSTATVTITVLDVNDNAP 81
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 294-389 8.64e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 44.26  E-value: 8.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686  294 TVPENATVGTSVLQVyasDTDADENGLVEYAINRRQSDK-EQMFRIDPRTGAIYINKALDFETKELHELVVVAKDHGEQP 372
Cdd:cd00031    5 SAVEGRSRGSFRVSI---PTDLIASSGEIIKISAAGKEAlPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANV 81

                         90
                 ....*....|....*..
gi 24580686  373 LETTAFVSIRVTDVNDN 389
Cdd:cd00031   82 PQTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
2985-3071 1.28e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.44  E-value: 1.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   2985 PQGYVVGQVTATDSDSGPDGRVVYQLSAPHS--HFKVNRSSGAVLIKRKLKldgdgdgnlYMDGRDISLVISASSGRHNS 3062
Cdd:pfam00028   10 PVGTEVLTVTATDPDLGPNGRIFYSILGGGPggNFRIDPDTGDISTTKPLD---------RESIGEYELTVEATDSGGPP 80


                   ....*....
gi 24580686   3063 LSSMAVVEI 3071
Cdd:pfam00028   81 LSSTATVTI 89
Cadherin pfam00028
Cadherin domain;
2653-2725 2.34e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 42.67  E-value: 2.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686   2653 YRAQISEAAPLGSVVLQLGQDALDQSL------AIIAGNEESAFELLQSKA-IVLVKPLDRERNDLYKLRLVLSHPHGPP 2725
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPngrifySILGGGPGGNFRIDPDTGdISTTKPLDRESIGEYELTVEATDSGGPP 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2994-3071 4.99e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.18  E-value: 4.99e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    2994 TATDSDSGPDGRVVYQLS--APHSHFKVNRSSGAVLIKRKLKldgdgdgnlYMDGRDISLVISASSGRHNSLSSMAVVEI 3071
Cdd:smart00112    1 SATDADSGENGKVTYSILsgNDDGLFSIDPETGEITTTKPLD---------REEQPEYTLTVEATDGGGPPLSSTATVTI 71
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2194-2320 2.09e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 39.64  E-value: 2.09e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580686    2194 DGRRQKVQFSFGAGNEDGILSLDSLSGEIRVNKPhlLDYDrfstpsmsalsrgralhyeeeidesseedpnnstrsqral 2273
Cdd:smart00112    7 SGENGKVTYSILSGNDDGLFSIDPETGEITTTKP--LDRE---------------------------------------- 44

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*..
gi 24580686    2274 tsssfaltnsQPNEIRVVLVARTADAPFLASYAELVIELEDENDNSP 2320
Cdd:smart00112   45 ----------EQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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