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Conserved domains on  [gi|17648075|ref|NP_523636|]
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tetraspanin 42Ej [Drosophila melanogaster]

Protein Classification

tetraspanin family protein( domain architecture ID 11992915)

tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

Gene Ontology:  GO:0016020
PubMed:  15763890|11756464|19709882|16024509
SCOP:  4001512

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 97-183 1.61e-17

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


:

Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 74.46  E-value: 1.61e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648075  97 AMREQLMGRFEERMRDLFERKTHSD---DKMQPVHSLFGCCGIEGPQDYLQEeHGALPSSCCYAFDCSKPAHVYEEGCST 173
Cdd:cd03127   2 VYRDQLESLVSDTLNDAWDEYYVDDdfqEAMDALQSTFECCGVNGPTDYLDL-RLLVPSSCCKGTDGNCGLNLYTEGCLE 80

                        90
                ....*....|
gi 17648075 174 KAVATLRMQA 183
Cdd:cd03127  81 KLVDFLRSNL 90
Tetraspanin pfam00335
Tetraspanin family;
11-135 1.82e-08

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 52.32  E-value: 1.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648075    11 KYGLLVTCILIVTCNVFFFSCGVttWGSAVSVYGSYGSALC-----------GGAVFGVAFLGMYVALKVSYKYSIYYLI 79
Cdd:pfam00335   2 KYLLFLFNLLFWLLGLLLLGVGV--WLLSAFSLLLLGLSEAsayipillivlGAVIFLVGFLGCCGALKENRCLLLTYFV 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17648075    80 CSGLVIA---ALGSYLFTFTA-----MREQLMGRFEERMRDLFERKTHSDDKMQPVHSLFGCCG 135
Cdd:pfam00335  80 LLLLLFLaelAAGILAFVYRDklsglLSNWLKKSLEDGYRDWLDLYSCLNSALDSLQSEFGCCG 143
 
Name Accession Description Interval E-value
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 97-183 1.61e-17

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 74.46  E-value: 1.61e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648075  97 AMREQLMGRFEERMRDLFERKTHSD---DKMQPVHSLFGCCGIEGPQDYLQEeHGALPSSCCYAFDCSKPAHVYEEGCST 173
Cdd:cd03127   2 VYRDQLESLVSDTLNDAWDEYYVDDdfqEAMDALQSTFECCGVNGPTDYLDL-RLLVPSSCCKGTDGNCGLNLYTEGCLE 80

                        90
                ....*....|
gi 17648075 174 KAVATLRMQA 183
Cdd:cd03127  81 KLVDFLRSNL 90
Tetraspanin pfam00335
Tetraspanin family;
11-135 1.82e-08

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 52.32  E-value: 1.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648075    11 KYGLLVTCILIVTCNVFFFSCGVttWGSAVSVYGSYGSALC-----------GGAVFGVAFLGMYVALKVSYKYSIYYLI 79
Cdd:pfam00335   2 KYLLFLFNLLFWLLGLLLLGVGV--WLLSAFSLLLLGLSEAsayipillivlGAVIFLVGFLGCCGALKENRCLLLTYFV 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17648075    80 CSGLVIA---ALGSYLFTFTA-----MREQLMGRFEERMRDLFERKTHSDDKMQPVHSLFGCCG 135
Cdd:pfam00335  80 LLLLLFLaelAAGILAFVYRDklsglLSNWLKKSLEDGYRDWLDLYSCLNSALDSLQSEFGCCG 143
 
Name Accession Description Interval E-value
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 97-183 1.61e-17

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 74.46  E-value: 1.61e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648075  97 AMREQLMGRFEERMRDLFERKTHSD---DKMQPVHSLFGCCGIEGPQDYLQEeHGALPSSCCYAFDCSKPAHVYEEGCST 173
Cdd:cd03127   2 VYRDQLESLVSDTLNDAWDEYYVDDdfqEAMDALQSTFECCGVNGPTDYLDL-RLLVPSSCCKGTDGNCGLNLYTEGCLE 80

                        90
                ....*....|
gi 17648075 174 KAVATLRMQA 183
Cdd:cd03127  81 KLVDFLRSNL 90
Tetraspanin pfam00335
Tetraspanin family;
11-135 1.82e-08

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 52.32  E-value: 1.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648075    11 KYGLLVTCILIVTCNVFFFSCGVttWGSAVSVYGSYGSALC-----------GGAVFGVAFLGMYVALKVSYKYSIYYLI 79
Cdd:pfam00335   2 KYLLFLFNLLFWLLGLLLLGVGV--WLLSAFSLLLLGLSEAsayipillivlGAVIFLVGFLGCCGALKENRCLLLTYFV 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17648075    80 CSGLVIA---ALGSYLFTFTA-----MREQLMGRFEERMRDLFERKTHSDDKMQPVHSLFGCCG 135
Cdd:pfam00335  80 LLLLLFLaelAAGILAFVYRDklsglLSNWLKKSLEDGYRDWLDLYSCLNSALDSLQSEFGCCG 143
CD53_like_LEL cd03164
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. ...
 98-175 2.15e-06

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD53 is a tetraspanin of the lymphoid-myeloid lineage and has been implicated in apoptosis protection. It associates with integrin alpha4beta1. Some of the cellular responses modulated by CD53 may be mediated by JNK activation and/or via the AKT pathway.


Pssm-ID: 239417 [Multi-domain]  Cd Length: 86  Bit Score: 44.39  E-value: 2.15e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648075  98 MREQLMGRF-EERMRDLFErKTHSD-------DKMQpvhSLFGCCGIEGPQDYLqeehGALPSSCcyafdCSKPAHVYEE 169
Cdd:cd03164   2 VYEKKLNNYvKEGLTDSLE-QYHKDnntseawDMIQ---SNLQCCGINGTTDWG----SGVPSSC-----CSSDTEYKVE 68


                ....*.
gi 17648075 170 GCSTKA 175
Cdd:cd03164  69 GCYKKL 74
TM4SF2_6_like_LEL cd03161
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. ...
 99-179 3.26e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 2 (TM4SF2) or Tspan-7, transmembrane 4 superfamily 6 (TM4SF6) or Tspan-6, and related proteins. TM4SF2 has been identified as involved in some forms of X-linked mental retardation.


Pssm-ID: 239414  Cd Length: 104  Bit Score: 38.88  E-value: 3.26e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648075  99 REQLMGRFEERMR------DLFERKTHSDDKMQpvHSLfGCCGIEGPQDYLQ----EEHGaLPSSCCYAF-DCS------ 161
Cdd:cd03161   4 RHEIKGTFLRTYNeavsnyNGDDERSDAVDTVQ--RTL-HCCGVENYTDWLNspyfLEKG-IPLSCCKNRsDCSpqdlkn 79

                        90       100
                ....*....|....*....|.
gi 17648075 162 ---KPAHVYEEGCSTKAVATL 179
Cdd:cd03161  80 ltkAATKVYQQGCFTLVTSFM 100
CD37_CD82_like_LEL cd03160
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ...
 133-174 2.87e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology.


Pssm-ID: 239413  Cd Length: 117  Bit Score: 36.59  E-value: 2.87e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17648075 133 CCGIEGPQDYLQ------EEHGALPSSCC------------YAFdCSKPA----HVYEEGCSTK 174
Cdd:cd03160  45 CCGWTGPQDWTDnsliknSSEPLYPCSCCnssatadsprpsKGF-CEAPAsldwPVYQEGCMEK 107
NET-5_like_LEL cd03165
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. ...
 127-180 5.68e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human tetraspan NET-5.


Pssm-ID: 239418 [Multi-domain]  Cd Length: 98  Bit Score: 35.03  E-value: 5.68e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 17648075 127 VHSLFGCCGIEGPQDYLQEEH-GALPSSCC--YAFDCSK--PAHVYEEGCSTKAVATLR 180
Cdd:cd03165  37 TQTEFRCCGVTNYTDWYEVLGeNRVPDSCCqeDSQDCGRnpTELWWKTGCYEKVQQWLV 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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