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Conserved domains on  [gi|22026786|ref|NP_523643|]
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tetraspanin 42Eq [Drosophila melanogaster]

Protein Classification

tetraspanin family protein( domain architecture ID 11992915)

tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

Gene Ontology:  GO:0016020
PubMed:  15763890|11756464|19709882|16024509
SCOP:  4001512

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 95-173 5.41e-15

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


:

Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 67.53  E-value: 5.41e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22026786  95 LAQPINYELLANETIYDAWQGQL---YHSDRMSYFEIKYHCCGQTGPANYPDSGLVIPQSCYFNQNATVTTDLYTVGCNH 171
Cdd:cd03127   1 FVYRDQLESLVSDTLNDAWDEYYvddDFQEAMDALQSTFECCGVNGPTDYLDLRLLVPSSCCKGTDGNCGLNLYTEGCLE 80


                ..
gi 22026786 172 QL 173
Cdd:cd03127  81 KL 82
Tetraspanin pfam00335
Tetraspanin family;
8-134 1.40e-11

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 60.80  E-value: 1.40e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22026786     8 LKVSSFVLDFLCCVLAALTIAACSYALIAFS-----HSVAIRVPSILGIVLGGLLFFSTIFGCIAALRESIRMTWIYAAI 82
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSllllgLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFVL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 22026786    83 LLALVFSQITVILAQPINYELLA-----------NETIYDAWQGQLYHSDRMSYFEIKYHCCG 134
Cdd:pfam00335  81 LLLLFLAELAAGILAFVYRDKLSgllsnwlkkslEDGYRDWLDLYSCLNSALDSLQSEFGCCG 143
 
Name Accession Description Interval E-value
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 95-173 5.41e-15

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 67.53  E-value: 5.41e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22026786  95 LAQPINYELLANETIYDAWQGQL---YHSDRMSYFEIKYHCCGQTGPANYPDSGLVIPQSCYFNQNATVTTDLYTVGCNH 171
Cdd:cd03127   1 FVYRDQLESLVSDTLNDAWDEYYvddDFQEAMDALQSTFECCGVNGPTDYLDLRLLVPSSCCKGTDGNCGLNLYTEGCLE 80


                ..
gi 22026786 172 QL 173
Cdd:cd03127  81 KL 82
Tetraspanin pfam00335
Tetraspanin family;
8-134 1.40e-11

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 60.80  E-value: 1.40e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22026786     8 LKVSSFVLDFLCCVLAALTIAACSYALIAFS-----HSVAIRVPSILGIVLGGLLFFSTIFGCIAALRESIRMTWIYAAI 82
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSllllgLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFVL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 22026786    83 LLALVFSQITVILAQPINYELLA-----------NETIYDAWQGQLYHSDRMSYFEIKYHCCG 134
Cdd:pfam00335  81 LLLLFLAELAAGILAFVYRDKLSgllsnwlkkslEDGYRDWLDLYSCLNSALDSLQSEFGCCG 143
 
Name Accession Description Interval E-value
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 95-173 5.41e-15

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 67.53  E-value: 5.41e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22026786  95 LAQPINYELLANETIYDAWQGQL---YHSDRMSYFEIKYHCCGQTGPANYPDSGLVIPQSCYFNQNATVTTDLYTVGCNH 171
Cdd:cd03127   1 FVYRDQLESLVSDTLNDAWDEYYvddDFQEAMDALQSTFECCGVNGPTDYLDLRLLVPSSCCKGTDGNCGLNLYTEGCLE 80


                ..
gi 22026786 172 QL 173
Cdd:cd03127  81 KL 82
Tetraspanin pfam00335
Tetraspanin family;
8-134 1.40e-11

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 60.80  E-value: 1.40e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22026786     8 LKVSSFVLDFLCCVLAALTIAACSYALIAFS-----HSVAIRVPSILGIVLGGLLFFSTIFGCIAALRESIRMTWIYAAI 82
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSllllgLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFVL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 22026786    83 LLALVFSQITVILAQPINYELLA-----------NETIYDAWQGQLYHSDRMSYFEIKYHCCG 134
Cdd:pfam00335  81 LLLLFLAELAAGILAFVYRDKLSgllsnwlkkslEDGYRDWLDLYSCLNSALDSLQSEFGCCG 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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