BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652500   34 FVDVTLSCEHGSLKAHKVVLSACSTYFQKLLLE-NPCKHPTIILPaDIIFTDLKTIIDFVYRGEIDVTESELQGLLRTAE 112
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILP-DVPYSELKALLDFIYTGEVNVSQEQLESLLKLAE 79

                 ....*.
gi 24652500  113 QLKIKG 118
Cdd:cd18315   80 LLQIKG 85

helix-turn-helix, Psq domain; This DNA-binding motif is found in four copies in the pipsqueak protein of Drosophila melanogaster. In pipsqueak this domain binds to GAGA sequence.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 24652500    837 TPEDLERALEAIRAGNTSVQKASAEFGIPTGTLYgRCKREGIELSR 882
Cdd:pfam05225    1 TPEALAEALEAVRNGQMSIRKAARIYGIPYSTLW-RRKRGKYSLKR 45

helix-turn-helix, Psq domain; This DNA-binding motif is found in four copies in the pipsqueak protein of Drosophila melanogaster. In pipsqueak this domain binds to GAGA sequence.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 24652500    728 TQDDMNSALDALKNQNMSLTKASAIYGIPSTTLWQR 763
Cdd:pfam05225    1 TPEALAEALEAVRNGQMSIRKAARIYGIPYSTLWRR 36

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652500   34 FVDVTLSCEHGSLKAHKVVLSACSTYFQKLLLE-NPCKHPTIILPaDIIFTDLKTIIDFVYRGEIDVTESELQGLLRTAE 112
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILP-DVPYSELKALLDFIYTGEVNVSQEQLESLLKLAE 79

                 ....*.
gi 24652500  113 QLKIKG 118
Cdd:cd18315   80 LLQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652500      36 DVTLSCEHGSLKAHKVVLSACSTYFQKLLLENPC--KHPTIILPaDIIFTDLKTIIDFVYRGEIDVTESELQGLLRTAEQ 113
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesDKSEIYLD-DVSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                            90
                    ....*....|...
gi 24652500     114 LKIKGLCETAENA 126
Cdd:smart00225   80 LQIPGLVELCEEF 92

helix-turn-helix, Psq domain; This DNA-binding motif is found in four copies in the pipsqueak protein of Drosophila melanogaster. In pipsqueak this domain binds to GAGA sequence.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 24652500    837 TPEDLERALEAIRAGNTSVQKASAEFGIPTGTLYgRCKREGIELSR 882
Cdd:pfam05225    1 TPEALAEALEAVRNGQMSIRKAARIYGIPYSTLW-RRKRGKYSLKR 45

helix-turn-helix, Psq domain; This DNA-binding motif is found in four copies in the pipsqueak protein of Drosophila melanogaster. In pipsqueak this domain binds to GAGA sequence.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 24652500    728 TQDDMNSALDALKNQNMSLTKASAIYGIPSTTLWQR 763
Cdd:pfam05225    1 TPEALAEALEAVRNGQMSIRKAARIYGIPYSTLWRR 36

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652500   34 FVDVTLSCEHGSLKAHKVVLSACSTYFQKLLLE-NPCKHPTIILPaDIIFTDLKTIIDFVYRGEIDVTESELQGLLRTAE 112
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILP-DVPYSELKALLDFIYTGEVNVSQEQLESLLKLAE 79

                 ....*.
gi 24652500  113 QLKIKG 118
Cdd:cd18315   80 LLQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652500      36 DVTLSCEHGSLKAHKVVLSACSTYFQKLLLENPC--KHPTIILPaDIIFTDLKTIIDFVYRGEIDVTESELQGLLRTAEQ 113
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesDKSEIYLD-DVSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                            90
                    ....*....|...
gi 24652500     114 LKIKGLCETAENA 126
Cdd:smart00225   80 LQIPGLVELCEEF 92

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652500   26 QQLREDLSFVDVTLSCEHGS-LKAHKVVLSACSTYFQKLLLENPCKHPTIILPADIIFTDLKTIIDFVYRGEIDVTESEL 104
Cdd:cd18311    6 QNLFNKTEYCDLTLQFRDNEqLKVHRLVLSACTDYFNVLEQTCEIVDDTLIMPNELQADAVVPVINFMYTGQLEFEEKSY 85

                         90       100
                 ....*....|....*....|
gi 24652500  105 QGLLRTAEQLKIKGLCETAE 124
Cdd:cd18311   86 GKLLRTAKELNMTVLLKLLE 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652500   23 SVFQQLREDLSFVDVTLSCEHGSLKAHKVVLSACSTYFQKLLL--ENPCKHPTIILP---ADIiftdLKTIIDFVYRGEI 97
Cdd:cd18240    6 NVFNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTngWNETEKKVYKIPgvsPEM----MELIIEYAYTRTV 81

                         90       100
                 ....*....|....*....|..
gi 24652500   98 DVTESELQGLLRTAEQLKIKGL 119
Cdd:cd18240   82 PITAENVEELLPAADQFNIMGI 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652500   16 NYQNTMTSVFQQLREDLSFVDVTLSCEHGSLKAHKVVLSACSTYFQKLLLENPCK-HPTIILPADIIFTDLKTIIDFVYR 94
Cdd:cd18256    2 KHASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSEsSKDVVQIHGVEPDIFHILLDFIYT 81

                         90       100
                 ....*....|....*....|..
gi 24652500   95 GEIDVTESELQGLLRTAEQLKI 116
Cdd:cd18256   82 GVVEVTVSNVQELLVAADMLQL 103

helix-turn-helix, Psq domain; This DNA-binding motif is found in four copies in the pipsqueak protein of Drosophila melanogaster. In pipsqueak this domain binds to GAGA sequence.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 24652500    837 TPEDLERALEAIRAGNTSVQKASAEFGIPTGTLYgRCKREGIELSR 882
Cdd:pfam05225    1 TPEALAEALEAVRNGQMSIRKAARIYGIPYSTLW-RRKRGKYSLKR 45

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652500   24 VFQQLREDLSFVDVTLSCEHGSLKAHKVVLSACSTYFQKLLLENPCKHPT-IILPADIIFTDLKTIIDFVYRGEIDVTES 102
Cdd:cd18339   11 VMNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAkKIEIKDVDGQTLSKLIDYIYTAEIEVTEE 90

                         90
                 ....*....|....
gi 24652500  103 ELQGLLRTAEQLKI 116
Cdd:cd18339   91 NVQVLLPAASLLQL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652500   23 SVFQQLREDLSFVDVTLSCEHGSLKAHKVVLSACSTYFQKLLLEN--PCKHPTIILpADIIFTDLKTIIDFVYRGEIDVT 100
Cdd:cd18247    8 PVMEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDmvESKQDEITM-QGIEPSALEALINFAYSGRIAID 86

                         90
                 ....*....|....*.
gi 24652500  101 ESELQGLLRTAEQLKI 116
Cdd:cd18247   87 TSNVQSLLVGASFLQL 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652500   26 QQLREDLSFVDVTLSCEHGSLKAHKVVLSACSTYFQKLLLENPCKHPTiilpADIIF-----TDLKTIIDFVYRGEIDVT 100
Cdd:cd18257   10 NLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKEN----SEVEFqcideTALQAIVEYAYTGTVFIS 85

                         90
                 ....*....|....*..
gi 24652500  101 ESELQGLLRTAEQLKIK 117
Cdd:cd18257   86 QATVESLLPAANLLQIK 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652500   24 VFQQLREDLSFVDVTLSCEHGSLKAHKVVLSACSTYFQKLLLENPCKHPTIILPADIIFTD-LKTIIDFVYRGEIDVTES 102
Cdd:cd18253    8 VFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEaMDCFLQYVYTGKVKITTE 87

                         90
                 ....*....|....*....
gi 24652500  103 ELQGLLRTAEQLKIKGLCE 121
Cdd:cd18253   88 NVQYLFETSSLFQISPLRD 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652500   24 VFQQLREDLSFVDVTLSCEHGSLKAHKVVLSACSTYFQKL----LLENPCKHPTIilpADIIFTDLKTIIDFVYRGEIDV 99
Cdd:cd18235   11 VMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMftgdLSESRANRVTL---QDVDGKALLLLIDYVYTAEIQV 87

                         90
                 ....*....|....*..
gi 24652500  100 TESELQGLLRTAEQLKI 116
Cdd:cd18235   88 TEENVQVLLPAANLLQL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652500   15 NNYQNTMTSVFQQLREDLSFVDVTLSCEHGSLKAHKVVLSACSTYFQ-KLLLenpcKHPTIILPADIIFTDLKTIIDFVY 93
Cdd:cd18208    6 HNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQdKLLL----GYSDIEIPSVVSVQSVQKLIDFMY 81

                         90       100
                 ....*....|....*....|....
gi 24652500   94 RGEIDVTESELQGLLRTAEQLKIK 117
Cdd:cd18208   82 SGVLRVSQSEALQILTAASILQIK 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652500   15 NNYQNTMTSVFQQLREDLSFVDVTLSCEHGSLKAHKVVLSACSTYFQKLL---LENPCKHPTII--LPADIiftdLKTII 89
Cdd:cd18242    2 NSHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFtseMSEKGKSEVELqgLTAST----MEILL 77

                         90       100
                 ....*....|....*....|....*....
gi 24652500   90 DFVYRGEIDVTESELQGLLRTAEQLKIKG 118
Cdd:cd18242   78 DFVYTETVHVTVENVQELLPAACLLQLKG 106

helix-turn-helix, Psq domain; This DNA-binding motif is found in four copies in the pipsqueak protein of Drosophila melanogaster. In pipsqueak this domain binds to GAGA sequence.

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 24652500    783 EDALQNALEALRSGQISANKASKAFGIPSSTLYKIARR 820
Cdd:pfam05225    2 PEALAEALEAVRNGQMSIRKAARIYGIPYSTLWRRKRG 39

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652500   24 VFQQLREDLSFVDVTLSCEHGSLKAHKVVLSACSTYFQKLLLENPCKHPTI-ILPADIIFTDLKTIIDFVYRGEIDVTES 102
Cdd:cd18237   11 VMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSeVELKDAEPDIIELLVEFAYTARISVNSN 90

                         90
                 ....*....|....
gi 24652500  103 ELQGLLRTAEQLKI 116
Cdd:cd18237   91 NVQSLLDAANQYQI 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652500   13 RWNNYQNTMTSVFQQLREDLSFVDVTLSCEHGSLKAHKVVLSACSTYFQKLL-LENPCKHPTIILPADIIFTDLKTIIDF 91
Cdd:cd18266    4 RWADHSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFtIGMREAHQKEVELVGASYIGLKAVIDF 83

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 24652500   92 VYRGEIDVTESELQGLLRTAEQLKIKGL----CETAEN 125
Cdd:cd18266   84 LYSSELPLDGGNIDYVLETAHLLQIWKVvdfcCEYLEN 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652500   28 LREDLSFVDVTLSCEHGSLKAHKVVLSACSTYFQKL----LLEnpCKHPTIILPAdIIFTDLKTIIDFVYRGEIDVTESE 103
Cdd:cd18255   12 LRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMftggMRE--SSQDEIELKG-VSAKGLKHILDFAYTSELTLDLDC 88

                         90
                 ....*....|...
gi 24652500  104 LQGLLRTAEQLKI 116
Cdd:cd18255   89 IQDVLGAAVHLQM 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652500   24 VFQQLREDLSFVDVTLSCEHGSLK----AHKVVLSACSTYFqKLLLENPCK------------HPTIIlpadiiftdlKT 87
Cdd:cd18248   11 IMNELRLSQQLCDVTLKVKYQDPKeefmAHKVVLASSSPYF-KAMFTSGLRecgmevvpiegvHPCVM----------SR 79

                         90       100
                 ....*....|....*....|....
gi 24652500   88 IIDFVYRGEIDVTESELQGLLRTA 111
Cdd:cd18248   80 LIEFAYTASISVGEKCVLHVLPGA 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652500   34 FVDVTLSCEHGSLKAHKVVLSACSTYFQ-KLLLenpcKHPTIILPADIIFTDLKTIIDFVYRGEIDVTESELQGLLRTAE 112
Cdd:cd18229   18 FCDVTVRIHDASLRAHRCVLAAGSPFFHdKLLL----GHSEIEVPPVVPAQTVRQLVEFMYSGSLVVAQSEALQILTAAS 93

                 ....*
gi 24652500  113 QLKIK 117
Cdd:cd18229   94 ILQIK 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652500   17 YQNTM-TSVFQQLREDLSFVDVTLSCEHGSLKAHKVVLSACSTYFQKLLL--ENPCKHPTIILPaDIIFTDLKTIIDFVY 93
Cdd:cd18341    9 YQSTLlQDGLKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLseESEEKKKEVVLD-NVDPNIMDMILKYLY 87

                         90       100
                 ....*....|....*....|...
gi 24652500   94 RGEIDVTESELQGLLRTAEQLKI 116
Cdd:cd18341   88 SAEIDLNDGNVQDIFALASRFQI 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652500   16 NYQNTMTSVFQQLREDLSFVDVTLSCEHGSLKAHKVVLSACSTYFQKL----LLENPCKHPTIilpADIIFTDLKTIIDF 91
Cdd:cd18261   10 SHKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMfslcMVESEADEVNL---HGVTSLGLKQALDF 86

                         90       100
                 ....*....|....*....|....*
gi 24652500   92 VYRGEIDVTESELQGLLRTAEQLKI 116
Cdd:cd18261   87 AYTGQILLEPGVIQDVLAAGSHLQL 111

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652500   33 SFVDVTLSCEHGS-LKAHKVVLSACSTYFQKLL----LENP-CKHPTIILPADIiftdLKTIIDFVYRGEID-VTESE-- 103
Cdd:cd18302    4 DLYDVTIVSEDGKeFPCHKCVLVARLEYFHSMLssswIEASsCSALTMPIPSDI----LEIILDYLYTDEASaVKESQnv 79

                         90       100
                 ....*....|....*....|....*
gi 24652500  104 --LQGLLRTAEQLKI---KGLCETA 123
Cdd:cd18302   80 efLCNVLVIADQLLItrlKEICEVA 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652500    8 QYFSLRWNNYQNTMTSVFQQLREDLSFVDVTLSCEHGSLKAHKVVLSACSTYFQKLLLENPCKhpTIILPADIIFTDLKT 87
Cdd:cd18290    1 QTLQMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSA--VVELPAAVQPQSFQQ 78

                         90       100       110
                 ....*....|....*....|....*....|....
gi 24652500   88 IIDFVYRGEIDVTESELQGLLRTAEQLKIKGLCE 121
Cdd:cd18290   79 ILSFCYTGRLSMNVGDQFLLMYTAGFLQIQEIME 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652500   34 FVDVTLSCEHGSLKAHKVVLSACSTYFQKLLLENP-CKHPTIILPADIIFTD---LKTIIDFVYRGEIDVTESELQGLLR 109
Cdd:cd18307    1 FCDVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDmKATDELSITIDCDYLSpetVEQLLDYFYTGKIVISEKNVEDLLK 80

                         90
                 ....*....|
gi 24652500  110 TAEQLKIKGL 119
Cdd:cd18307   81 GAKYFNIPRL 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652500    6 GHQYFSLRWNNYQNTMTSVfQQLREDLSFVDVTLSCEHGSLKAHKVVLSACSTYFQKL----LLENPCKHPTIilpADII 81
Cdd:cd18246   12 GHSISHNSKRHYHDAFVSM-NRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMftneMSESRQTHVTL---HDID 87

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 24652500   82 FTDLKTIIDFVYRGEIDVTESELQGLLRTAEQLKIKGL 119
Cdd:cd18246   88 PQALEQLVQYAYTAEIVVGEGNVQTLLPAASLLQLNGV 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652500   33 SFVDVTLSCEHGSLKAHKVVLSACSTYFQKLLLENPCKHPTIIlpADIIFTDLKTIIDFVYRGEIDVTESELQGLLRTAE 112
Cdd:cd18226   21 SFCDLVITVEGKEFSAHKVVVAVGSSYFHACLSKNPNTDAVTL--DHVSYSVFQHLLEFLYTSEFFVYENEIPLVLEAAK 98

                 ....
gi 24652500  113 QLKI 116
Cdd:cd18226   99 FLDI 102