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Conserved domains on  [gi|17647425|ref|NP_523817|]
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fibrillarin [Drosophila melanogaster]

Protein Classification

rRNA 2'-O-methyltransferase fibrillarin family protein( domain architecture ID 10015233)

rRNA 2'-O-methyltransferase fibrillarin family protein is a S-adenosyl-L-methionine (SAM)-dependent methyltransferase that has the ability to methylate both RNAs and proteins, and may be involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00146 PTZ00146
fibrillarin; Provisional
 109-344 5.13e-170

fibrillarin; Provisional


:

Pssm-ID: 240291  Cd Length: 293  Bit Score: 474.61  E-value: 5.13e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647425  109 KTVTIEPHRHEGVFIARGKEDALVTRNFVPGSEVYGEKRISVETN--GEKIEYRVWNPFRSKLAAAVLGGVEQIHMPPGS 186
Cdd:PTZ00146  55 GKVIVVPHRFPGVFIAKGKSDALVTKNMVPGESVYGEKRISVEDAegGEKIEYRVWNPFRSKLAAAIIGGVANIPIKPGS 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647425  187 KVLYLGAASGTTVSHVSDVVGPEGLVYAVEFSHRSGRDLINVAKKRTNIIPIIEDARHPHKYRMLVGMVDTIFADVAQPD 266
Cdd:PTZ00146 135 KVLYLGAASGTTVSHVSDLVGPEGVVYAVEFSHRSGRDLTNMAKKRPNIVPIIEDARYPQKYRMLVPMVDVIFADVAQPD 214

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17647425  267 QGRIVALNAQHFLKNGGHFVISIKASCIDSTAQPEAVFAAEVKKMQADKLKPQEQLTLEPYERDHAVVVGVYRPPPKQ 344
Cdd:PTZ00146 215 QARIVALNAQYFLKNGGHFIISIKANCIDSTAKPEVVFASEVQKLKKEGLKPKEQLTLEPFERDHAVVIGVYRPVKKK 292
 
Name Accession Description Interval E-value
PTZ00146 PTZ00146
fibrillarin; Provisional
 109-344 5.13e-170

fibrillarin; Provisional


Pssm-ID: 240291  Cd Length: 293  Bit Score: 474.61  E-value: 5.13e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647425  109 KTVTIEPHRHEGVFIARGKEDALVTRNFVPGSEVYGEKRISVETN--GEKIEYRVWNPFRSKLAAAVLGGVEQIHMPPGS 186
Cdd:PTZ00146  55 GKVIVVPHRFPGVFIAKGKSDALVTKNMVPGESVYGEKRISVEDAegGEKIEYRVWNPFRSKLAAAIIGGVANIPIKPGS 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647425  187 KVLYLGAASGTTVSHVSDVVGPEGLVYAVEFSHRSGRDLINVAKKRTNIIPIIEDARHPHKYRMLVGMVDTIFADVAQPD 266
Cdd:PTZ00146 135 KVLYLGAASGTTVSHVSDLVGPEGVVYAVEFSHRSGRDLTNMAKKRPNIVPIIEDARYPQKYRMLVPMVDVIFADVAQPD 214

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17647425  267 QGRIVALNAQHFLKNGGHFVISIKASCIDSTAQPEAVFAAEVKKMQADKLKPQEQLTLEPYERDHAVVVGVYRPPPKQ 344
Cdd:PTZ00146 215 QARIVALNAQYFLKNGGHFIISIKANCIDSTAKPEVVFASEVQKLKKEGLKPKEQLTLEPFERDHAVVIGVYRPVKKK 292
Fibrillarin pfam01269
Fibrillarin;
113-340 5.58e-147

Fibrillarin;


Pssm-ID: 396019  Cd Length: 227  Bit Score: 413.53  E-value: 5.58e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647425   113 IEPH-RHEGVFIAR-GKEDA-LVTRNFVPGSEVYGEKRISVETNgekiEYRVWNPFRSKLAAAVLGGVEQIHMPPGSKVL 189
Cdd:pfam01269   1 VEPHeRFEGVYIVKlGDGDArLATKNLVPGESVYGEKLIKVEGE----EYRVWNPFRSKLAAAILKGLKEIPIKPGSKVL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647425   190 YLGAASGTTVSHVSDVVGPEGLVYAVEFSHRSGRDLINVAKKRTNIIPIIEDARHPHKYRMLVGMVDTIFADVAQPDQGR 269
Cdd:pfam01269  77 YLGAASGTTVSHVSDIVGPEGVVYAVEFSPRVGRELINVAKKRPNIVPILEDARHPQKYRMLVEMVDVIFADVAQPDQAR 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17647425   270 IVALNAQHFLKNGGHFVISIKASCIDSTAQPEAVFAAEVKKMQADKLKPQEQLTLEPYERDHAVVVGVYRP 340
Cdd:pfam01269 157 ILALNARYFLKEGGYFMISIKARSIDVTKEPEEVFKREVRKLKEEGFKPIEQVHLEPYEKDHAMVVGKYKR 227
NOP1 COG1889
Fibrillarin-like rRNA 2'-O-methylase NOP1 [Translation, ribosomal structure and biogenesis];
114-339 9.19e-102

Fibrillarin-like rRNA 2'-O-methylase NOP1 [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441493  Cd Length: 222  Bit Score: 298.65  E-value: 9.19e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647425 114 EPHRHEGVFIAR-GKEDALVTRNFVPGSEVYGEKRISVEtngeKIEYRVWNPFRSKLAAAVLGGVEQIHMPPGSKVLYLG 192
Cdd:COG1889   1 MEELFEGVYRVEfDGEKRLATKNLVPGKRVYGERLIKIE----GVEYREWDPRRSKLAAAILKGLKELPIKEGSKVLYLG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647425 193 AASGTTVSHVSDVVgPEGLVYAVEFSHRSGRDLINVAKKRTNIIPIIEDARHPHKYRMLVGMVDTIFADVAQPDQGRIVA 272
Cdd:COG1889  77 AASGTTVSHVSDIV-PEGPVYAVEFAPRVMRDLLEVAESRPNIIPILADARKPEEYAHVVEKVDVIYQDVAQPNQAEIAI 155

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17647425 273 LNAQHFLKNGGHFVISIKASCIDSTAQPEAVFAAEVKKMQADKLKPQEQLTLEPYERDHAVVVGVYR 339
Cdd:COG1889 156 KNADFFLKKGGYLLLAIKARSIDVTKDPKEIFKEEIRKLEERGFEILEIIDLEPYHKDHLMVVARKK 222
 
Name Accession Description Interval E-value
PTZ00146 PTZ00146
fibrillarin; Provisional
 109-344 5.13e-170

fibrillarin; Provisional


Pssm-ID: 240291  Cd Length: 293  Bit Score: 474.61  E-value: 5.13e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647425  109 KTVTIEPHRHEGVFIARGKEDALVTRNFVPGSEVYGEKRISVETN--GEKIEYRVWNPFRSKLAAAVLGGVEQIHMPPGS 186
Cdd:PTZ00146  55 GKVIVVPHRFPGVFIAKGKSDALVTKNMVPGESVYGEKRISVEDAegGEKIEYRVWNPFRSKLAAAIIGGVANIPIKPGS 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647425  187 KVLYLGAASGTTVSHVSDVVGPEGLVYAVEFSHRSGRDLINVAKKRTNIIPIIEDARHPHKYRMLVGMVDTIFADVAQPD 266
Cdd:PTZ00146 135 KVLYLGAASGTTVSHVSDLVGPEGVVYAVEFSHRSGRDLTNMAKKRPNIVPIIEDARYPQKYRMLVPMVDVIFADVAQPD 214

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17647425  267 QGRIVALNAQHFLKNGGHFVISIKASCIDSTAQPEAVFAAEVKKMQADKLKPQEQLTLEPYERDHAVVVGVYRPPPKQ 344
Cdd:PTZ00146 215 QARIVALNAQYFLKNGGHFIISIKANCIDSTAKPEVVFASEVQKLKKEGLKPKEQLTLEPFERDHAVVIGVYRPVKKK 292
Fibrillarin pfam01269
Fibrillarin;
113-340 5.58e-147

Fibrillarin;


Pssm-ID: 396019  Cd Length: 227  Bit Score: 413.53  E-value: 5.58e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647425   113 IEPH-RHEGVFIAR-GKEDA-LVTRNFVPGSEVYGEKRISVETNgekiEYRVWNPFRSKLAAAVLGGVEQIHMPPGSKVL 189
Cdd:pfam01269   1 VEPHeRFEGVYIVKlGDGDArLATKNLVPGESVYGEKLIKVEGE----EYRVWNPFRSKLAAAILKGLKEIPIKPGSKVL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647425   190 YLGAASGTTVSHVSDVVGPEGLVYAVEFSHRSGRDLINVAKKRTNIIPIIEDARHPHKYRMLVGMVDTIFADVAQPDQGR 269
Cdd:pfam01269  77 YLGAASGTTVSHVSDIVGPEGVVYAVEFSPRVGRELINVAKKRPNIVPILEDARHPQKYRMLVEMVDVIFADVAQPDQAR 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17647425   270 IVALNAQHFLKNGGHFVISIKASCIDSTAQPEAVFAAEVKKMQADKLKPQEQLTLEPYERDHAVVVGVYRP 340
Cdd:pfam01269 157 ILALNARYFLKEGGYFMISIKARSIDVTKEPEEVFKREVRKLKEEGFKPIEQVHLEPYEKDHAMVVGKYKR 227
NOP1 COG1889
Fibrillarin-like rRNA 2'-O-methylase NOP1 [Translation, ribosomal structure and biogenesis];
114-339 9.19e-102

Fibrillarin-like rRNA 2'-O-methylase NOP1 [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441493  Cd Length: 222  Bit Score: 298.65  E-value: 9.19e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647425 114 EPHRHEGVFIAR-GKEDALVTRNFVPGSEVYGEKRISVEtngeKIEYRVWNPFRSKLAAAVLGGVEQIHMPPGSKVLYLG 192
Cdd:COG1889   1 MEELFEGVYRVEfDGEKRLATKNLVPGKRVYGERLIKIE----GVEYREWDPRRSKLAAAILKGLKELPIKEGSKVLYLG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647425 193 AASGTTVSHVSDVVgPEGLVYAVEFSHRSGRDLINVAKKRTNIIPIIEDARHPHKYRMLVGMVDTIFADVAQPDQGRIVA 272
Cdd:COG1889  77 AASGTTVSHVSDIV-PEGPVYAVEFAPRVMRDLLEVAESRPNIIPILADARKPEEYAHVVEKVDVIYQDVAQPNQAEIAI 155

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17647425 273 LNAQHFLKNGGHFVISIKASCIDSTAQPEAVFAAEVKKMQADKLKPQEQLTLEPYERDHAVVVGVYR 339
Cdd:COG1889 156 KNADFFLKKGGYLLLAIKARSIDVTKDPKEIFKEEIRKLEERGFEILEIIDLEPYHKDHLMVVARKK 222
PRK04266 PRK04266
fibrillarin-like rRNA/tRNA 2'-O-methyltransferase;
113-339 1.85e-101

fibrillarin-like rRNA/tRNA 2'-O-methyltransferase;


Pssm-ID: 235267  Cd Length: 226  Bit Score: 297.95  E-value: 1.85e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647425  113 IEPHRHEGVFIaRGKEDA---LVTRNFVPGSEVYGEKRISVETNgekiEYRVWNPFRSKLAAAVLGGVEQIHMPPGSKVL 189
Cdd:PRK04266   3 KKKEIFEGVYE-VEFEDGskrLATKNLVPGKRVYGERLIKWEGV----EYREWNPRRSKLAAAILKGLKNFPIKKGSKVL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647425  190 YLGAASGTTVSHVSDVVGpEGLVYAVEFSHRSGRDLINVAKKRTNIIPIIEDARHPHKYRMLVGMVDTIFADVAQPDQGR 269
Cdd:PRK04266  78 YLGAASGTTVSHVSDIVE-EGVVYAVEFAPRPMRELLEVAEERKNIIPILADARKPERYAHVVEKVDVIYQDVAQPNQAE 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647425  270 IVALNAQHFLKNGGHFVISIKASCIDSTAQPEAVFAAEVKKMQADKLKPQEQLTLEPYERDHAVVVGVYR 339
Cdd:PRK04266 157 IAIDNAEFFLKDGGYLLLAIKARSIDVTKDPKEIFKEEIRKLEEGGFEILEVVDLEPYHKDHAAVVARKK 226
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 184-287 2.23e-04

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 42.07  E-value: 2.23e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647425 184 PGSKVLYLGAASGTTVSHVSDVVGPEGLVYAVEFShrsgRDLINVAKKR-------TNIIPIIEDARHPhkyrMLVGMVD 256
Cdd:COG2519  91 PGARVLEAGTGSGALTLALARAVGPEGKVYSYERR----EDFAEIARKNlerfglpDNVELKLGDIREG----IDEGDVD 162

                        90       100       110
                ....*....|....*....|....*....|..
gi 17647425 257 TIFADVAQPdqgrIVALNAQH-FLKNGGHFVI 287
Cdd:COG2519 163 AVFLDMPDP----WEALEAVAkALKPGGVLVA 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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