BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647553  32 PADLTIVCEnKVKLHAHKLVLAAASPLIRNLLEDThLSDCSTTVYFPDVNATYFKFLLDFLYSGQTCITSRDVNYLHDLL 111
Cdd:cd18315   1 LVDVTLACE-GGSLKAHKLVLAAASPYFAALLKET-PPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLA 78

                ....*.
gi 17647553 112 LLLQIK 117
Cdd:cd18315  79 ELLQIK 84

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 17647553   500 YRCEYCGKQFGMSWNLKTHLRVH 522
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647553  32 PADLTIVCEnKVKLHAHKLVLAAASPLIRNLLEDThLSDCSTTVYFPDVNATYFKFLLDFLYSGQTCITSRDVNYLHDLL 111
Cdd:cd18315   1 LVDVTLACE-GGSLKAHKLVLAAASPYFAALLKET-PPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLA 78

                ....*.
gi 17647553 112 LLLQIK 117
Cdd:cd18315  79 ELLQIK 84

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647553    27 FRGEHPADLTIVCENKvKLHAHKLVLAAASPLIRNLLEDTHLSDCSTTVYFPDVNATYFKFLLDFLYSGQTCITSRDVNY 106
Cdd:pfam00651   5 REQGELCDVTLVVGDK-EFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKLISEENVDDL 83

                  ..
gi 17647553   107 LH 108
Cdd:pfam00651  84 LA 85

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 17647553   500 YRCEYCGKQFGMSWNLKTHLRVH 522
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647553  32 PADLTIVCEnKVKLHAHKLVLAAASPLIRNLLEDThLSDCSTTVYFPDVNATYFKFLLDFLYSGQTCITSRDVNYLHDLL 111
Cdd:cd18315   1 LVDVTLACE-GGSLKAHKLVLAAASPYFAALLKET-PPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLA 78

                ....*.
gi 17647553 112 LLLQIK 117
Cdd:cd18315  79 ELLQIK 84

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17647553     34 DLTIVCENKvKLHAHKLVLAAASPLIRNLLEDTHLSDCSTTVYFPDVNATYFKFLLDFLYSGQTCITSRDVNYL 107
Cdd:smart00225   1 DVTLVVGGK-KFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEEL 73

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647553  15 HGECILKEIGAAFRGEHPADLTIVCENKvKLHAHKLVLAAASPLIRNLL-----EdthlSDCSTtVYFPDVNATYFKFLL 89
Cdd:cd18287   5 HVHFLSEDIGALFLNEEYSDVTFVVEEK-RFPAHRVILAARSEYFRALLyggmrE----SQQSE-IELKDTNAEAFKALL 78

                ....*..
gi 17647553  90 DFLYSGQ 96
Cdd:cd18287  79 KYIYTGR 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647553  13 SKHGECILKEIGAAFRGEHPADLTIVCENKVkLHAHKLVLAAASPLIRNLL-----EDTHLSDCSTTVYFPDVnatyFKF 87
Cdd:cd18329   2 SSHQSRLLQQLDEQRKQELFCDCSILVEGQV-FKAHRNVLFASSGYFKMLLsqnakETGQPTVATFDVFSPDT----FTI 76

                        90
                ....*....|....*..
gi 17647553  88 LLDFLYSGQTCITSRDV 104
Cdd:cd18329  77 ILDFVYSGKLSLTSQNV 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647553  14 KHGECILKEIGAAFRGEHPADLTIVCeNKVKLHAHKLVLAAASP----LIRNLLEDTHLSdcstTVYFPDVNATYFKFLL 89
Cdd:cd18256   2 KHASLILAQLNKLRGQHEFCDVQLQV-GMELFSVHRLVLAASSPyfaaLFAGGMSESSKD----VVQIHGVEPDIFHILL 76

                        90
                ....*....|....*...
gi 17647553  90 DFLYSGQTCITSRDVNYL 107
Cdd:cd18256  77 DFIYTGVVEVTVSNVQEL 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17647553  27 FRGE-HPADLTIVCENKvKLHAHKLVLAAASPLIRNLLE-DTHLSDCSTT-VYFPDVNATYFKFLLDFLYSGQTCIT 100
Cdd:cd18245   8 FREEpHLCDATLVVGGE-EIPVQKNVLAAASPYFRAKLNyNPPKDDGSTYkIELEGISVEVMEEILDYIYTGQIKLS 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 17647553  44 KLHAHKLVLAAASPLIRNLLEDTHLSDCSTTVYFPDVNATYFKFLLDFLY 93
Cdd:cd18280  25 KFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIY 74

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647553   7 MLMLQYSKHgecILKEIGAAFRGEHPADLTIVCeNKVKLHAHKLVLAAASPLIRNLLEDTHLSDCSTTVYFPDvnatYFK 86
Cdd:cd18225   1 MELPNYSRQ---LLQQLHTLRKEQQFCDCTIFI-GTFHFRAHKLVLAASSLLFKSLLDSTDTISIDASVVSPE----EFA 72

                        90
                ....*....|
gi 17647553  87 FLLDFLYSGQ 96
Cdd:cd18225  73 LLLEMVYTGK 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647553  20 LKE-IGAAFRGEHPADLTIVC---ENKVKLHAHKLVLAAASPLIRNLLeDTHLSDCSTTVYFPDVNATYFKFLLDFLYSG 95
Cdd:cd18281   9 VKErFAFLFNNETLSDVHFIVgkgDNEQRIPAHKFVLSIGSAVFDAMF-NGGMATTSAEIELPDVEPAAFLALLRFLYSD 87

                ....
gi 17647553  96 QTCI 99
Cdd:cd18281  88 EVQI 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17647553  34 DLTIVCENkVKLHAHKLVLAAASPLIRNLLEDTHLSDCSTTVYFPDVNATYFKFLLDFLYSGQTCITSRDVNYL 107
Cdd:cd18338  23 DVTIVAED-VEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYTAEIQVTEENVQVL 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17647553  34 DLTIVCENKVkLHAHKLVLAAASPLIRNLL-EDTHLSDCSTTVYFPDVNATYFKFLLDFLYSGQTCITSRDV 104
Cdd:cd18230  23 DVCIIVEGKI-FKAHKNVLLGSSRYFKTLYcQVQKTSDQATVTHLDIVTAQGFKAIIDFMYSAHLALTSKNV 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647553  10 LQYSKHGECILKEIGAAFRGEHPADLTIVCeNKVKLHAHKLVLAAASPLIRNLLEDTHLSDCSTTVYFPDVNATYFKFLL 89
Cdd:cd18331   2 IQFTRHASDVLLNLNRLRSRDILTDVVIVV-SREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFNILL 80

                ....*
gi 17647553  90 DFLYS 94
Cdd:cd18331  81 DFMYT 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647553  11 QYSKHGECILKEIGAAFRGEHPADLTIVCENKvKLHAHKLVLAAASPLIRNLLEDTHLSDCSTTVYFPDVNATYFKFLLD 90
Cdd:cd18261   7 QSKSHKDAVLAALNQQRNDGILCDITLVAEEQ-KFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQALD 85

                ....*.
gi 17647553  91 FLYSGQ 96
Cdd:cd18261  86 FAYTGQ 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647553  15 HGECILKEIGAAFRGEHPADLTIVCENkVKLHAHKLVLAAASPLIRNLLEDTHLSDCSTTVYFPDVNATYFKFLLDFLYS 94
Cdd:cd18257   1 HSEQLLQGLNLLRQHHELCDVVLRVGD-VKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYT 79

                        90       100
                ....*....|....*....|....
gi 17647553  95 GQTCITSRDVNYLHDLLLLLQIKS 118
Cdd:cd18257  80 GTVFISQATVESLLPAANLLQIKL 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17647553  34 DLTIVCENKVkLHAHKLVLAAASPLIRNLLEDTHLSDCSTTVyfpdVNATYFKFLLDFLYSGQ 96
Cdd:cd18334  23 DVIIVVENAL-FRAHKNILAASSMYFKSLVLHDNLINLDTDM----VNPTVFRQILDFIYTGK 80

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*.
gi 17647553   514 NLKTHLRVHTGEKPFACRLCVAMFKQ 539
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647553  10 LQYSKHGECILKEIGAAFRGEHPADLTIVCENkVKLHAHKLVLAAASPLIRNLLEDTHlsDCSTTVYFPD-VNATYFKFL 88
Cdd:cd18212   1 IHSKTHKDTVLTNFEEQRKKDFLCDITLIVEN-VQFRAHKALLAASSEYFSMMFADEG--EVGQSIYMLEgMVAETFGAL 77

                        90
                ....*....|....*....
gi 17647553  89 LDFLYSGQTCITSRDVNYL 107
Cdd:cd18212  78 LEFIYTGCLQVGEKSLEQI 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647553  17 ECILKE-IGAAFRGEHPADLTIVCENKvKLHAHKLVLAAASPLIRNLLEDTHLSDCSTTVYFPDVNATYFKFLLDFLYSG 95
Cdd:cd18343   5 ECRLAEdLGNLWENSRFTDCSLFVGGQ-EFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTG 83

                ..
gi 17647553  96 QT 97
Cdd:cd18343  84 KA 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647553  15 HGECILkEIGAAFRGEHPADLTIVCENKVKLHAHKLVLAAASPLIRNLLEDTHLSDCSTTVYFPDVNATYFKFLLDFLYS 94
Cdd:cd18253   1 HSESIL-QVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYT 79

                        90       100
                ....*....|....*....|..
gi 17647553  95 GQTCITSRDVNYLHDLLLLLQI 116
Cdd:cd18253  80 GKVKITTENVQYLFETSSLFQI 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647553  34 DLTIVCENKvKLHAHKLVLAAASPLIRNLLEDTHLSDCSTTVYFPDVNATYFKFLLDFLYSGQTCITSRDVNYLHDLLLL 113
Cdd:cd18237  23 DVILIVEGR-EIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYTARISVNSNNVQSLLDAANQ 101

                ...
gi 17647553 114 LQI 116
Cdd:cd18237 102 YQI 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 17647553  47 AHKLVLAAASPLIRNLLE-DTHLSDCStTVYFPDVNATYFKFLLDFLYSGQ 96
Cdd:cd18306  32 AHRAVLACASPYLFELFSsDSDGESIL-TVKLDGLDPDAVEVLVNYAYTSR 81

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17647553  33 ADLTIVCENKVKLHAHKLVLAAASPLIRNLLEDTHLSDCSTTVYFPDVNATYFKFLLDFLYSGQTCITSRDVNYL 107
Cdd:cd18252  22 TDITLQCASGQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVYTSQICITERNVQSL 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647553  31 HPADLTIVCEN---KVKLHAHKLVLAAASPLIRNLLEDTHLSDCS-TTVYFPDVNATYFKFLLDFLYSGQTCITSRDVNY 106
Cdd:cd18211  24 HLCDVTVQVEHqgsKEEFSAHKAVLAASSKYFKEVFLNEKISDGKnTNVMLNEIYTADFASFLEFVYTAKVEVEEDRVQR 103

                ...
gi 17647553 107 LHD 109
Cdd:cd18211 104 MLE 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana BTB/POZ and TAZ domain-containing proteins, BT1-5; BT1-5 may act as substrate-specific adaptors of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. They contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17647553  33 ADLTIVCENKVKLHAHKLVLAAASPLIRNLLEDTHLSDCSTTVYFPDVNATYFKFLLDFLYSgqTCITSRDVN 105
Cdd:cd18313   2 ADVEIETDNNSHIPAHSNVLASASPVIAGMLKQPRRKSSKKVIKILGVPCDAVRVFIRFLYS--SCYEEEEME 72

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647553  17 ECILKE-IGAAFRGEHPADLTIVCENKvKLHAHKLVLAAASPLIRNLLEDTHLSDCSTTVYFPDVNATYFKFLLDFLYSG 95
Cdd:cd18279   2 ECRLAEdLGNLWENSRFTDCCLCVGGQ-EFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTG 80

                ..
gi 17647553  96 QT 97
Cdd:cd18279  81 KA 82

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17647553  33 ADLTIVCENKVKLHAHKLVLAAASPLIRNLLEDTHLSDCSTTVYF------PDVNATY--FKFLLDFLYSGQ 96
Cdd:cd18310  19 SDAEIIVEGGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPKLelreliPGGIVGYdaFMLVLSYLYSGR 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647553  33 ADLTIVCENKvKLHAHKLVLAAASPLIRNLLEDTHLSDCSTTVYFPDVNATYFKFLLDFLYSGQTCITSRDVNYLHDLLL 112
Cdd:cd18272  33 ADVTISVEGK-EFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYHGTVKLRVEELQETYEVAD 111

                ....*.
gi 17647553 113 LLQIKS 118
Cdd:cd18272 112 MYQLTA 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17647553  34 DLTIVCENKVkLHAHKLVLAAASPLIRNLL-EDTHLSDCSTTVYFPDVNATYFKFLLDFLYSGQTCITSRDV 104
Cdd:cd18330  20 DCSIIVEGRI-FKAHRNILFANSGYFRALLiHYIQDSGRHSTASLDIVTSEAFSIILDFLYSGKLDLCSENV 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647553  14 KHGECILKEIGAAFRGEHPADLTIVCENKvKLHAHKLVLAAASPLIRNLLEDTHLSDCSTTVYFPDVNATYFKFLLDFLY 93
Cdd:cd18249   5 KHPRQTLEAINLLRKHRELCDVVLVVGAK-KIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFAY 83

                        90
                ....*....|....
gi 17647553  94 SGQTCITSRDVNYL 107
Cdd:cd18249  84 TSQITVEEGNVQTL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647553  17 ECILKE-IGAAFRGEHPADLTIvCENKVKLHAHKLVLAAASPLIRNLLEDTHLSDCSTTVYFPDVNATYFKFLLDFLYSG 95
Cdd:cd18345   2 ECRLSDdLGLLFERSAFSDVTL-CVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTG 80

                ..
gi 17647553  96 QT 97
Cdd:cd18345  81 KA 82