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Conserved domains on  [gi|24762822|ref|NP_523862|]
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gooseberry-neuro [Drosophila melanogaster]

Protein Classification

homeobox protein( domain architecture ID 11021495)

homeobox protein with a paired box domain similar to mammalian Pax6, a transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas, and Drosophila gooseberry-neuro, which is involved in defining the polarity of embryonic segments

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_CRP super family cl46859
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
 20-141 1.08e-77

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


The actual alignment was detected with superfamily member pfam00292:

Pssm-ID: 481199  Cd Length: 125  Bit Score: 237.46  E-value: 1.08e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762822    20 GQGRVNQLGGVFINGRPLPNHIRLKIVEMAASGVRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPKVTSPEI 99
Cdd:pfam00292   1 GHGGVNQLGGVFVNGRPLPDHIRQKIVELAHSGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPEV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 24762822   100 ETRIDELRKENPSIFSWEIREKLIKEGFAD---PPSTSSISRLLR 141
Cdd:pfam00292  81 VTKIAEYKRENPSIFAWEIRDRLLKEGVCDndtVPSVSSINRILR 125
Homeodomain pfam00046
Homeodomain;
183-239 9.76e-27

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 101.81  E-value: 9.76e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 24762822   183 RRSRTTFTAEQLEALERAFSRTQYPDVYTREELAQTTALTEARIQVWFSNRRARLRK 239
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
 
Name Accession Description Interval E-value
PAX pfam00292
'Paired box' domain;
20-141 1.08e-77

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 237.46  E-value: 1.08e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762822    20 GQGRVNQLGGVFINGRPLPNHIRLKIVEMAASGVRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPKVTSPEI 99
Cdd:pfam00292   1 GHGGVNQLGGVFVNGRPLPDHIRQKIVELAHSGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPEV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 24762822   100 ETRIDELRKENPSIFSWEIREKLIKEGFAD---PPSTSSISRLLR 141
Cdd:pfam00292  81 VTKIAEYKRENPSIFAWEIRDRLLKEGVCDndtVPSVSSINRILR 125
PAX cd00131
Paired Box domain
 20-144 1.24e-73

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 227.30  E-value: 1.24e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762822  20 GQGRVNQLGGVFINGRPLPNHIRLKIVEMAASGVRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPKVTSPEI 99
Cdd:cd00131   1 GQGGVNQLGGVFVNGRPLPDSIRQRIVELAQSGIRPCDISRQLRVSHGCVSKILNRYYETGSIRPGAIGGSKPRVATPEV 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 24762822 100 ETRIDELRKENPSIFSWEIREKLIKEGFADP---PSTSSISRLLRGSD 144
Cdd:cd00131  81 VKKIEIYKQENPGMFAWEIRDRLLQEGVCDKsnvPSVSSINRILRNKA 128
PAX smart00351
Paired Box domain;
20-141 1.31e-69

Paired Box domain;


Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 216.80  E-value: 1.31e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762822     20 GQGRVNQLGGVFINGRPLPNHIRLKIVEMAASGVRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPKVTSPEI 99
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLCVSHGCVSKILGRYYETGSIRPGAIGGSKPKVATPKV 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 24762822    100 ETRIDELRKENPSIFSWEIREKLIKEGFADP---PSTSSISRLLR 141
Cdd:smart00351  81 VKKIADYKQENPGIFAWEIRDRLLSEGVCDKdnvPSVSSINRILR 125
Homeodomain pfam00046
Homeodomain;
183-239 9.76e-27

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 101.81  E-value: 9.76e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 24762822   183 RRSRTTFTAEQLEALERAFSRTQYPDVYTREELAQTTALTEARIQVWFSNRRARLRK 239
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 183-241 7.66e-24

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 93.85  E-value: 7.66e-24
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24762822 183 RRSRTTFTAEQLEALERAFSRTQYPDVYTREELAQTTALTEARIQVWFSNRRARLRKHS 241
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 182-238 8.77e-24

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 93.47  E-value: 8.77e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 24762822    182 QRRSRTTFTAEQLEALERAFSRTQYPDVYTREELAQTTALTEARIQVWFSNRRARLR 238
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
180-256 1.61e-13

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 67.85  E-value: 1.61e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24762822 180 RKQRRSRTTFTAEQLEALERAFSRTQYPDVYTREELAQTTALTEARIQVWFSNRRARLRKHSGGSNSGLSPMNSGSS 256
Cdd:COG5576  49 SPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGKVEQRPGEEEADL 125
transpos_IS630 NF033545
IS630 family transposase;
42-141 3.66e-11

IS630 family transposase;


Pssm-ID: 468076 [Multi-domain]  Cd Length: 298  Bit Score: 63.81  E-value: 3.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762822   42 RLKIVEMAASGVRPCVISRQLRVSHGCVSKILNRYQETG--SIRPGVIGGSKPKVTSPEIETRIDELRKENPSIFS-WEI 118
Cdd:NF033545   2 RARILLLAAEGLSITEIAERLGVSRSTVYRWLKRFNEGGleGLLDKPRPGRPRKLLSEQQAELLALLLEEPPEGAGhWTL 81

                         90       100
                 ....*....|....*....|....*
gi 24762822  119 RE--KLIKEGFADPPSTSSISRLLR 141
Cdd:NF033545  82 RElaALLEEEFGVEYSRSTVRRLLK 106
Csa3 COG3415
CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein ...
 42-141 8.37e-10

CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein Csa3, CARF domain is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 442641 [Multi-domain]  Cd Length: 325  Bit Score: 59.87  E-value: 8.37e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762822  42 RLKIVEMAASGVRPCVISRQLRVSHGCVSKILNRYQETG--SIRPGVIGGSKPKVTSPEIETRIDELRKENPSIFS-WEI 118
Cdd:COG3415  28 RLRAVLLLAEGLSVREIAERLGVSRSTVYRWLKRYREGGlaGLKDRPRGGRPSKLSDEQRERLLELLREKSPDQGSrWTL 107

                        90       100
                ....*....|....*....|....*
gi 24762822 119 RE--KLIKEGFADPPSTSSISRLLR 141
Cdd:COG3415 108 AElaELLEEEFGVEVSPSTVRRLLK 132
 
Name Accession Description Interval E-value
PAX pfam00292
'Paired box' domain;
20-141 1.08e-77

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 237.46  E-value: 1.08e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762822    20 GQGRVNQLGGVFINGRPLPNHIRLKIVEMAASGVRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPKVTSPEI 99
Cdd:pfam00292   1 GHGGVNQLGGVFVNGRPLPDHIRQKIVELAHSGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPEV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 24762822   100 ETRIDELRKENPSIFSWEIREKLIKEGFAD---PPSTSSISRLLR 141
Cdd:pfam00292  81 VTKIAEYKRENPSIFAWEIRDRLLKEGVCDndtVPSVSSINRILR 125
PAX cd00131
Paired Box domain
 20-144 1.24e-73

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 227.30  E-value: 1.24e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762822  20 GQGRVNQLGGVFINGRPLPNHIRLKIVEMAASGVRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPKVTSPEI 99
Cdd:cd00131   1 GQGGVNQLGGVFVNGRPLPDSIRQRIVELAQSGIRPCDISRQLRVSHGCVSKILNRYYETGSIRPGAIGGSKPRVATPEV 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 24762822 100 ETRIDELRKENPSIFSWEIREKLIKEGFADP---PSTSSISRLLRGSD 144
Cdd:cd00131  81 VKKIEIYKQENPGMFAWEIRDRLLQEGVCDKsnvPSVSSINRILRNKA 128
PAX smart00351
Paired Box domain;
20-141 1.31e-69

Paired Box domain;


Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 216.80  E-value: 1.31e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762822     20 GQGRVNQLGGVFINGRPLPNHIRLKIVEMAASGVRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPKVTSPEI 99
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLCVSHGCVSKILGRYYETGSIRPGAIGGSKPKVATPKV 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 24762822    100 ETRIDELRKENPSIFSWEIREKLIKEGFADP---PSTSSISRLLR 141
Cdd:smart00351  81 VKKIADYKQENPGIFAWEIRDRLLSEGVCDKdnvPSVSSINRILR 125
Homeodomain pfam00046
Homeodomain;
183-239 9.76e-27

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 101.81  E-value: 9.76e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 24762822   183 RRSRTTFTAEQLEALERAFSRTQYPDVYTREELAQTTALTEARIQVWFSNRRARLRK 239
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 183-241 7.66e-24

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 93.85  E-value: 7.66e-24
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24762822 183 RRSRTTFTAEQLEALERAFSRTQYPDVYTREELAQTTALTEARIQVWFSNRRARLRKHS 241
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 182-238 8.77e-24

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 93.47  E-value: 8.77e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 24762822    182 QRRSRTTFTAEQLEALERAFSRTQYPDVYTREELAQTTALTEARIQVWFSNRRARLR 238
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
180-256 1.61e-13

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 67.85  E-value: 1.61e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24762822 180 RKQRRSRTTFTAEQLEALERAFSRTQYPDVYTREELAQTTALTEARIQVWFSNRRARLRKHSGGSNSGLSPMNSGSS 256
Cdd:COG5576  49 SPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGKVEQRPGEEEADL 125
transpos_IS630 NF033545
IS630 family transposase;
42-141 3.66e-11

IS630 family transposase;


Pssm-ID: 468076 [Multi-domain]  Cd Length: 298  Bit Score: 63.81  E-value: 3.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762822   42 RLKIVEMAASGVRPCVISRQLRVSHGCVSKILNRYQETG--SIRPGVIGGSKPKVTSPEIETRIDELRKENPSIFS-WEI 118
Cdd:NF033545   2 RARILLLAAEGLSITEIAERLGVSRSTVYRWLKRFNEGGleGLLDKPRPGRPRKLLSEQQAELLALLLEEPPEGAGhWTL 81

                         90       100
                 ....*....|....*....|....*
gi 24762822  119 RE--KLIKEGFADPPSTSSISRLLR 141
Cdd:NF033545  82 RElaALLEEEFGVEYSRSTVRRLLK 106
Csa3 COG3415
CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein ...
 42-141 8.37e-10

CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein Csa3, CARF domain is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 442641 [Multi-domain]  Cd Length: 325  Bit Score: 59.87  E-value: 8.37e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762822  42 RLKIVEMAASGVRPCVISRQLRVSHGCVSKILNRYQETG--SIRPGVIGGSKPKVTSPEIETRIDELRKENPSIFS-WEI 118
Cdd:COG3415  28 RLRAVLLLAEGLSVREIAERLGVSRSTVYRWLKRYREGGlaGLKDRPRGGRPSKLSDEQRERLLELLREKSPDQGSrWTL 107

                        90       100
                ....*....|....*....|....*
gi 24762822 119 RE--KLIKEGFADPPSTSSISRLLR 141
Cdd:COG3415 108 AElaELLEEEFGVEVSPSTVRRLLK 132
HTH_32 pfam13565
Homeodomain-like domain;
69-140 1.53e-05

Homeodomain-like domain;


Pssm-ID: 463923 [Multi-domain]  Cd Length: 73  Bit Score: 42.67  E-value: 1.53e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24762822    69 VSKILNRYQETG--SIRPGVIGGSKPKVTsPEIETRIDELRKENPsifSWEIRE--KLIKEGFADPPSTSSISRLL 140
Cdd:pfam13565   2 VYRWRKRYNEEGleGLEDRPRRGRPRKLT-DEQEARLLALLCEEP---RWSPRLlaERLEEEFGVKVSRSTVRRIL 73
HTH_23 pfam13384
Homeodomain-like domain;
41-80 2.68e-05

Homeodomain-like domain;


Pssm-ID: 433164 [Multi-domain]  Cd Length: 50  Bit Score: 41.49  E-value: 2.68e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 24762822    41 IRLKIVEMAASGVRPCVISRQLRVSHGCVSKILNRYQETG 80
Cdd:pfam13384   6 RRARALLLLAEGLSVKEIAELLGVSRRTVYRWLKRYNEEG 45
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 206-236 7.05e-04

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 37.11  E-value: 7.05e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 24762822   206 YPDVYTREELAQTTALTEARIQVWFSNRRAR 236
Cdd:pfam05920   9 YPSEEEKAELAKETGLSRKQISNWFINARRR 39
HTH_28 pfam13518
Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is ...
 42-80 2.44e-03

Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding.


Pssm-ID: 463908 [Multi-domain]  Cd Length: 52  Bit Score: 36.03  E-value: 2.44e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 24762822    42 RLKIVEMAASGVRPCVISRQLRVSHGCVSKILNRYQETG 80
Cdd:pfam13518   2 RLKIVLLALEGESIKEAARLFGISRSTVYRWIRRYREGG 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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