NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|24654863|ref|NP_523876|]
View 

extra macrochaetae [Drosophila melanogaster]

Protein Classification

basic helix-loop-helix domain-containing protein( domain architecture ID 14444564)

basic helix-loop-helix (bHLH) domain-containing protein is a DNA-binding protein that may act as a transcription factor

CATH:  4.10.280.10
Gene Ontology:  GO:0003677|GO:0046983
PubMed:  20219281|15186484|1755826|8018712
SCOP:  4000913

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
bHLH_dnHLH_EMC_like cd19695
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein ...
 32-83 1.73e-26

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein extra-macrochaetae and similar proteins; Extra-macrochaetae is a negative regulator of sensory organ development in Drosophila. It belongs to dominant negative group of helix-loop-helix (dnHLH) proteins, which lack a basic DNA-binding domain but can form heterodimers with other HLH proteins, thereby inhibiting DNA binding.


:

Pssm-ID: 381538  Cd Length: 52  Bit Score: 95.90  E-value: 1.73e-26
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 24654863  32 GDGENAEMKMYLSKLKDLVPFMPKNRKLTKLEIIQHVIDYICDLQTELETHP 83
Cdd:cd19695   1 LNQERREMALYLAKLRNLVPTLPKNRKVSKLELLQHVIDYIADLEEQLEDHP 52
 
Name Accession Description Interval E-value
bHLH_dnHLH_EMC_like cd19695
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein ...
 32-83 1.73e-26

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein extra-macrochaetae and similar proteins; Extra-macrochaetae is a negative regulator of sensory organ development in Drosophila. It belongs to dominant negative group of helix-loop-helix (dnHLH) proteins, which lack a basic DNA-binding domain but can form heterodimers with other HLH proteins, thereby inhibiting DNA binding.


Pssm-ID: 381538  Cd Length: 52  Bit Score: 95.90  E-value: 1.73e-26
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 24654863  32 GDGENAEMKMYLSKLKDLVPFMPKNRKLTKLEIIQHVIDYICDLQTELETHP 83
Cdd:cd19695   1 LNQERREMALYLAKLRNLVPTLPKNRKVSKLELLQHVIDYIADLEEQLEDHP 52
HLH smart00353
helix loop helix domain;
37-81 2.11e-10

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 54.15  E-value: 2.11e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 24654863     37 AEMKMYLSKLKDLVPFMPKNRKLTKLEIIQHVIDYICDLQTELET 81
Cdd:smart00353   9 RKINEAFDELRSLLPTLPKNKKLSKAEILRLAIEYIKSLQEELQK 53
HLH pfam00010
Helix-loop-helix DNA-binding domain;
37-76 2.71e-09

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 50.92  E-value: 2.71e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 24654863    37 AEMKMYLSKLKDLVPFMPKNRKLTKLEIIQHVIDYICDLQ 76
Cdd:pfam00010  14 DRINDAFDELRELLPTLPPDKKLSKAEILRLAIEYIKHLQ 53
 
Name Accession Description Interval E-value
bHLH_dnHLH_EMC_like cd19695
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein ...
 32-83 1.73e-26

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein extra-macrochaetae and similar proteins; Extra-macrochaetae is a negative regulator of sensory organ development in Drosophila. It belongs to dominant negative group of helix-loop-helix (dnHLH) proteins, which lack a basic DNA-binding domain but can form heterodimers with other HLH proteins, thereby inhibiting DNA binding.


Pssm-ID: 381538  Cd Length: 52  Bit Score: 95.90  E-value: 1.73e-26
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 24654863  32 GDGENAEMKMYLSKLKDLVPFMPKNRKLTKLEIIQHVIDYICDLQTELETHP 83
Cdd:cd19695   1 LNQERREMALYLAKLRNLVPTLPKNRKVSKLELLQHVIDYIADLEEQLEDHP 52
bHLH_dnHLH_ID cd19684
basic helix-loop-helix (bHLH) domain found in the DNA-binding protein inhibitor (ID) family; ...
 32-78 2.81e-23

basic helix-loop-helix (bHLH) domain found in the DNA-binding protein inhibitor (ID) family; The ID family includes a dominant negative group of helix-loop-helix (dnHLH) proteins, ID1-4, that are negative regulators of bHLH transcription factors. They contain the HLH-dimerization domain but lack the basic domain necessary for DNA-binding. ID proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins. They also interact with many non-bHLH proteins in complex networks. ID proteins have been implicated in regulating gene expression as well as cell-cycle progression. Whereas ID-1, ID-2 and ID-3, are generally considered as tumor promoters, ID4 on the contrary has emerged as a tumor suppressor.


Pssm-ID: 381527  Cd Length: 47  Bit Score: 87.32  E-value: 2.81e-23
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 24654863  32 GDGENAEMKMYLSKLKDLVPFMPKNRKLTKLEIIQHVIDYICDLQTE 78
Cdd:cd19684   1 NDILNAEMQDCYSKLKELVPTIPQNKKVSKVEILQHVIDYILDLQLA 47
bHLH_dnHLH_ID1 cd19691
basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID1 and similar ...
 38-83 6.12e-16

basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID1 and similar proteins; ID1, also termed Class B basic helix-loop-helix protein 24 (bHLHb24), or inhibitor of DNA binding 1, or inhibitor of differentiation 1, is a dominant negative helix-loop-helix (dnHLH) transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the bHLH transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. ID1 interferes with centrosomal function. It has been implicated in the regulation of cell proliferation and differentiation in myogenesis, neurogenesis, and/or hematopoiesis.


Pssm-ID: 381534  Cd Length: 52  Bit Score: 68.67  E-value: 6.12e-16
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 24654863  38 EMKMYLSKLKDLVPFMPKNRKLTKLEIIQHVIDYICDLQTELETHP 83
Cdd:cd19691   7 DMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIWDLQVELDSGP 52
bHLH_dnHLH_ID4 cd19694
basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID4 and similar ...
 38-85 8.01e-15

basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID4 and similar proteins; ID4, also termed Class B basic helix-loop-helix protein 27 (bHLHb27), or inhibitor of DNA binding 4, or inhibitor of differentiation 4, is a dominant negative helix-loop-helix (dnHLH) transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the bHLH transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. It plays a role in adipose cell differentiation.


Pssm-ID: 381537  Cd Length: 60  Bit Score: 65.80  E-value: 8.01e-15
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 24654863  38 EMKMYLSKLKDLVPFMPKNRKLTKLEIIQHVIDYICDLQTELETHPEM 85
Cdd:cd19694  10 DMNDCYSRLKRLVPTIPPNKKVSKVEILQHVIDYILDLQLALETHPAL 57
bHLH_dnHLH_ID2 cd19692
basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID2 and similar ...
 44-83 1.11e-14

basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID2 and similar proteins; ID2, also termed Class B basic helix-loop-helix protein 26 (bHLHb26), or inhibitor of DNA binding 2, or inhibitor of differentiation 2, is a dominant negative helix-loop-helix (dnHLH) transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the bHLH transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. It has been implicated in the regulation of cell proliferation and differentiation in myogenesis, neurogenesis, and/or hematopoiesis.


Pssm-ID: 381535  Cd Length: 66  Bit Score: 65.81  E-value: 1.11e-14
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 24654863  44 SKLKDLVPFMPKNRKLTKLEIIQHVIDYICDLQTELETHP 83
Cdd:cd19692  27 SKLKELVPSIPQNKKVSKMEILQHVIDYILDLQIALDSHP 66
bHLH_dnHLH_ID3 cd19693
basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID3 and similar ...
 31-78 3.79e-11

basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID3 and similar proteins; ID3, also termed Class B basic helix-loop-helix protein 25 (bHLHb25), or helix-loop-helix protein HEIR-1, or ID-like protein inhibitor HLH 1R21, or inhibitor of DNA binding 3, or inhibitor of differentiation 3, is a dominant negative helix-loop-helix (dnHLH) transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the bHLH transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. It negatively regulates muscle differentiation by inhibiting the DNA-binding activities of the myogenic regulatory factors.


Pssm-ID: 381536  Cd Length: 61  Bit Score: 56.33  E-value: 3.79e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 24654863  31 RGDGENAEMKMYL--------SKLKDLVPFMPKNRKLTKLEIIQHVIDYICDLQTE 78
Cdd:cd19693   6 SNKGPALEEPVSLlydmndcySRLRELVPGVPQGTKLSQVEILQHVIDYILDLQIV 61
HLH smart00353
helix loop helix domain;
37-81 2.11e-10

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 54.15  E-value: 2.11e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 24654863     37 AEMKMYLSKLKDLVPFMPKNRKLTKLEIIQHVIDYICDLQTELET 81
Cdd:smart00353   9 RKINEAFDELRSLLPTLPKNKKLSKAEILRLAIEYIKSLQEELQK 53
HLH pfam00010
Helix-loop-helix DNA-binding domain;
37-76 2.71e-09

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 50.92  E-value: 2.71e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 24654863    37 AEMKMYLSKLKDLVPFMPKNRKLTKLEIIQHVIDYICDLQ 76
Cdd:pfam00010  14 DRINDAFDELRELLPTLPPDKKLSKAEILRLAIEYIKHLQ 53
bHLH_SF cd00083
basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators ...
 39-76 6.79e-07

basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. Members of the bHLH superfamily have two highly conserved and functionally distinct regions. The basic part is at the amino end of the bHLH that may bind DNA to a consensus hexanucleotide sequence known as the E box (CANNTG). Different families of bHLH proteins recognize different E-box consensus sequences. At the carboxyl-terminal end of the region is the HLH region that interacts with other proteins to form homo- and heterodimers. bHLH proteins function as a diverse set of regulatory factors because they recognize different DNA sequences and dimerize with different proteins. The bHLH proteins can be divided to cell-type specific and widely expressed proteins. The cell-type specific members of bHLH superfamily are involved in cell-fate determination and act in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis.


Pssm-ID: 381392 [Multi-domain]  Cd Length: 46  Bit Score: 44.43  E-value: 6.79e-07
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 24654863  39 MKMYLSKLKDLVPFMPKNRKLTKLEIIQHVIDYICDLQ 76
Cdd:cd00083   8 INDAFEELKRLLPELPDSKKLSKASILQKAVEYIRELQ 45
bHLH_TS_FIGLA cd11422
basic helix-loop-helix (bHLH) domain found in factor in the germline alpha (FIGLA) and similar ...
 44-80 2.43e-05

basic helix-loop-helix (bHLH) domain found in factor in the germline alpha (FIGLA) and similar proteins; FIGLA, also termed FIGalpha, or Class C basic helix-loop-helix protein 8 (bHLHc8), or folliculogenesis-specific basic helix-loop-helix protein, or transcription factor FIGa, is a germ-cell-specific bHLH transcription factor expressed abundantly in female and less so in male germ cells. It is essential for primordial follicle formation and expression of many genes required for folliculogenesis, fertilization and early embryonic survival. FIGLA knockout mice cannot form primordial follicles and lose oocytes rapidly after birth, whereas male gonads are unaffected.


Pssm-ID: 381428  Cd Length: 56  Bit Score: 40.41  E-value: 2.43e-05
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 24654863  44 SKLKDLVPFMPKNRKLTKLEIIQHVIDYICDLQTELE 80
Cdd:cd11422  20 SKLRRIVPLIPRDRKPSKVDTLKGATEYIRLLQRILE 56
bHLH_TS_ASCL cd11418
basic helix-loop-helix (bHLH) domain found in achaete-scute complex-like (ASCL) family; The ...
 44-79 3.90e-05

basic helix-loop-helix (bHLH) domain found in achaete-scute complex-like (ASCL) family; The achaete-scute complex-like (ASCL, also known as achaete-scute complex homolog or ASH) family of bHLH transcription factors, ASCL1-5, have been implicated in cell fate specification and differentiation. They are critical for proper development of the nervous system. The deregulation of ASCL plays a key role in psychiatric and neurological disorders. ASCL-1, also termed Class A basic helix-loop-helix protein 46 (bHLHa46), or achaete-scute homolog 1 (ASH-1), or mammalian achaete-scute homolog 1 (Mash1), is a neural-specific bHLH transcription factor that is expressed in subsets of neural progenitors in both the central and peripheral nervous system. It plays a key role in neuronal differentiation and specification in the nervous system. ASCL-2, also termed achaete-scute homolog 2 (ASH-2), or Class A basic helix-loop-helix protein 45 (bHLHa45), or mammalian achaete-scute homolog 2 (Mash2), is a bHLH transcription factor that is involved in Schwann cell differentiation and control of proliferation in adult peripheral nerves. ASCL-3, also termed Class A basic helix-loop-helix protein 42 (bHLHa42), or bHLH transcriptional regulator Sgn-1, or achaete-scute homolog 3 (ASH-3), is a bHLH transcription factor specifically localized in the duct cells of the salivary glands. It may act as transcriptional repressor that inhibits myogenesis. The family also includes Drosophila melanogaster achaete-scute complex (AS-C) proteins, which consists of lethal of scute (also known as achaete-scute complex protein T3 or AST3), scute (also known as achaete-scute complex protein T4 or AST4), achaete (also known as achaete-scute complex protein T5 or AST5), and asense (also known as achaete-scute complex protein T8 or AST8). They are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system, as well as in sex determination and dosage compensation.


Pssm-ID: 381424 [Multi-domain]  Cd Length: 56  Bit Score: 39.90  E-value: 3.90e-05
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 24654863  44 SKLKDLVPFMPKNRKLTKLEIIQHVIDYICDLQTEL 79
Cdd:cd11418  21 DRLRQHVPYLKRRKKLSKVKTLRRAIEYIRHLQKLL 56
bHLH_TS cd11390
tissue specific basic helix-loop-helix (bHLH-TS) domain family; Tissue specific bHLH domain ...
 43-79 4.61e-04

tissue specific basic helix-loop-helix (bHLH-TS) domain family; Tissue specific bHLH domain family includes transcription regulators whose expression are restricted to certain tissues. They are involved in cell-fate determination and process in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis and include proteins from myogenic regulatory factor (MRF) family, twist-related protein (TWIST) family, scleraxis-like family, heart- and neural crest derivatives-expressed protein (HAND) family, helix-loop-helix protein (HEN) family, musculin-like family, germline alpha (FIGLA) family, T-cell acute lymphocytic leukemia protein/ lymphoblastic leukemia-derived sequence (TAL/LYL) family, ovary, uterus and testis protein (OUT) family, mesoderm posterior protein (Mesp) family, muscle, intestine and stomach expression 1 (MIST-1) family, protein atonal homologs (ATOH) family, neurogenin (NGN) family, neurogenic differentiation factor (NeuroD) family, achaete-scute complex-like (ASCL) family, Fer3-like protein (FERD3L)-like family, and Oligodendrocyte lineage genes (OLIG) family of transcription factors.


Pssm-ID: 381396 [Multi-domain]  Cd Length: 55  Bit Score: 36.78  E-value: 4.61e-04
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 24654863  43 LSKLKDLVPFMPKNRKLTKLEIIQHVIDYICDLQTEL 79
Cdd:cd11390  19 FEALRKVLPTVPPDKKLSKIETLRLAINYIAALSDLL 55
bHLH_AtPRE_like cd11442
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana paclobutrazol resistance ...
 38-84 3.72e-03

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana paclobutrazol resistance (PRE) family; The PRE family includes several bHLH transcription factors from Arabidopsis thaliana, such as PRE1-6. PRE1 (also termed AtbHLH136, or protein banquo 1), PRE2 (also termed AtbHLH134, or protein banquo 2, or EN 52), PRE4 (also termed AtbHLH161, or protein banquo 3), and PRE5 (also termed AtbHLH164) are atypical and probable non DNA-binding bHLH transcription factors that integrate multiple signaling pathways to regulate cell elongation and plant development. PRE3 (also termed AtbHLH135, or protein activation-tagged BRI1 suppressor 1, or ATBS1, or protein target of MOOPTEROS 7, or EN 67) is an atypical and probable non DNA-binding bHLH transcription factor required for MONOPTEROS-dependent root initiation in embryo. It promotes the correct definition of the hypophysis cell division plane. PRE5 (also termed AtbHLH163, or protein KIDARI) is an atypical and probable non DNA-binding bHLH transcription factor that regulates light-mediated responses in day light conditions by binding and inhibiting the activity of the bHLH transcription factor HFR1, a critical regulator of light signaling and shade avoidance.


Pssm-ID: 381448  Cd Length: 65  Bit Score: 34.59  E-value: 3.72e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 24654863  38 EMKMYLSKLKDLVPFMPKNRKLTKLEIIQHVIDYICDLQTELETHPE 84
Cdd:cd11442  11 QKNDLYSRLRALLPSIATSDKVSKATVLEEACNYIRNLHREVDDLSE 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH