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Conserved domains on  [gi|17647315|ref|NP_523983|]
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division abnormally delayed, isoform A [Drosophila melanogaster]

Protein Classification

glypican family protein( domain architecture ID 10471748)

glypican family protein is a cell surface proteoglycan that bears heparan sulfate, similar to human glypican-1 that binds alpha-4 (V) collagen and participates in Schwann cell myelination

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glypican pfam01153
Glypican;
51-622 0e+00

Glypican;


:

Pssm-ID: 460084  Cd Length: 554  Bit Score: 627.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647315    51 RLQRDSRAKDAVGGsTHQCDAVKSY-----FESIDIKSSGTYSEKGAIC--GGNCCNNATELELRDKAAGMFEQLLHHHT 123
Cdd:pfam01153   4 LLALPGRADPASGK-ARSCSEVRQLysakgFSLNDVPQSEISGEHLRICpqGYTCCTSEMEEKLSNQSRREFEQLVHEAS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647315   124 SSLRGVLETNAKQFQSHVLELAQISENMTHSLFSKVYTRMVPSSRMMIHQLYTEIMNHliytsnYTNSNgqlgrrgigsv 203
Cdd:pfam01153  83 SSLQTTLTTNHRKFDEFFRELLNISENSLNDMFVRTYGRLYTQNAELFKDLFTELRRY------YRGSN----------- 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647315   204 qSNLEEAVRHFFVQLFPVAYhQMVHLSKnNLGDlheDYVNCLQHNFDEMHPFGDIPQQVQSNLGKSVHMSNVFMNALLQA 283
Cdd:pfam01153 146 -VNLEEALNEFWARLLERLF-KLVNPQY-HFSD---DYLECLSKQTEQLKPFGDVPRKLKLQLTRAFIAARAFVQGLNLG 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647315   284 AEVLSEADALygeQLTDTCKLHLLKMHYCPNCNGHHSssrseTKLCYGYCKNVMRGCSAEYAGlLDSPWSGVVDSLnNLV 363
Cdd:pfam01153 220 REVVNKVSQV---PLSPECTRALMKMLYCPHCRGLPS-----VKPCYNYCLNVMRGCLANQAD-LDTEWRNFIDSL-LLV 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647315   364 TTHILSDTGIINVIKHLQTYFSEAIMAAMHNGPELEKKVKKTCGTPSLTPYSSgEPDARP------------PPHKNNVK 431
Cdd:pfam01153 290 AERLEGPFNIENVIDSIHVKISEAIMNMQENSMKLTAKVFQGCGTPKPTPYRS-TRSSSPeekkkrgfrtytPEERPTTA 368

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647315   432 WATDPDPGMVLFLSTIDKSKEFYTTIVDNFCDEQQHSRDDHS---CWSGDRFGDYTQLLINPGTDSQRYNPEVPFNAKAQ 508
Cdd:pfam01153 369 AGTRLDRLVTDVKEKLKEMKSFWSTLPDTLCSDEKMAADPTNedkCWNGQTKGRYLPEVMGNGLANQINNPEVEVDITKP 448

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647315   509 TGKLNELVDKLFKIRKSIGAAAPSNSIQAtHDIQNDMgegsgggegqIGddeEEYGGAHGSGDGSGDGP------HTPIE 582
Cdd:pfam01153 449 DMVIRQQIMKLKIMTNRLKNAYPGNDVDF-QDDSDDS----------SG---SGSGDGCPSDLCKGDLPfvfeltDTPAT 514

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|
gi 17647315   583 ESEGTTTNEVESRDSGKTSGSNPLEGTATWMLLTLVTMLF 622
Cdd:pfam01153 515 PAKPTTQQGTGSVDGSSTGGLPSSLLLATSMLLSLVTLLV 554
 
Name Accession Description Interval E-value
Glypican pfam01153
Glypican;
51-622 0e+00

Glypican;


Pssm-ID: 460084  Cd Length: 554  Bit Score: 627.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647315    51 RLQRDSRAKDAVGGsTHQCDAVKSY-----FESIDIKSSGTYSEKGAIC--GGNCCNNATELELRDKAAGMFEQLLHHHT 123
Cdd:pfam01153   4 LLALPGRADPASGK-ARSCSEVRQLysakgFSLNDVPQSEISGEHLRICpqGYTCCTSEMEEKLSNQSRREFEQLVHEAS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647315   124 SSLRGVLETNAKQFQSHVLELAQISENMTHSLFSKVYTRMVPSSRMMIHQLYTEIMNHliytsnYTNSNgqlgrrgigsv 203
Cdd:pfam01153  83 SSLQTTLTTNHRKFDEFFRELLNISENSLNDMFVRTYGRLYTQNAELFKDLFTELRRY------YRGSN----------- 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647315   204 qSNLEEAVRHFFVQLFPVAYhQMVHLSKnNLGDlheDYVNCLQHNFDEMHPFGDIPQQVQSNLGKSVHMSNVFMNALLQA 283
Cdd:pfam01153 146 -VNLEEALNEFWARLLERLF-KLVNPQY-HFSD---DYLECLSKQTEQLKPFGDVPRKLKLQLTRAFIAARAFVQGLNLG 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647315   284 AEVLSEADALygeQLTDTCKLHLLKMHYCPNCNGHHSssrseTKLCYGYCKNVMRGCSAEYAGlLDSPWSGVVDSLnNLV 363
Cdd:pfam01153 220 REVVNKVSQV---PLSPECTRALMKMLYCPHCRGLPS-----VKPCYNYCLNVMRGCLANQAD-LDTEWRNFIDSL-LLV 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647315   364 TTHILSDTGIINVIKHLQTYFSEAIMAAMHNGPELEKKVKKTCGTPSLTPYSSgEPDARP------------PPHKNNVK 431
Cdd:pfam01153 290 AERLEGPFNIENVIDSIHVKISEAIMNMQENSMKLTAKVFQGCGTPKPTPYRS-TRSSSPeekkkrgfrtytPEERPTTA 368

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647315   432 WATDPDPGMVLFLSTIDKSKEFYTTIVDNFCDEQQHSRDDHS---CWSGDRFGDYTQLLINPGTDSQRYNPEVPFNAKAQ 508
Cdd:pfam01153 369 AGTRLDRLVTDVKEKLKEMKSFWSTLPDTLCSDEKMAADPTNedkCWNGQTKGRYLPEVMGNGLANQINNPEVEVDITKP 448

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647315   509 TGKLNELVDKLFKIRKSIGAAAPSNSIQAtHDIQNDMgegsgggegqIGddeEEYGGAHGSGDGSGDGP------HTPIE 582
Cdd:pfam01153 449 DMVIRQQIMKLKIMTNRLKNAYPGNDVDF-QDDSDDS----------SG---SGSGDGCPSDLCKGDLPfvfeltDTPAT 514

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|
gi 17647315   583 ESEGTTTNEVESRDSGKTSGSNPLEGTATWMLLTLVTMLF 622
Cdd:pfam01153 515 PAKPTTQQGTGSVDGSSTGGLPSSLLLATSMLLSLVTLLV 554
 
Name Accession Description Interval E-value
Glypican pfam01153
Glypican;
51-622 0e+00

Glypican;


Pssm-ID: 460084  Cd Length: 554  Bit Score: 627.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647315    51 RLQRDSRAKDAVGGsTHQCDAVKSY-----FESIDIKSSGTYSEKGAIC--GGNCCNNATELELRDKAAGMFEQLLHHHT 123
Cdd:pfam01153   4 LLALPGRADPASGK-ARSCSEVRQLysakgFSLNDVPQSEISGEHLRICpqGYTCCTSEMEEKLSNQSRREFEQLVHEAS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647315   124 SSLRGVLETNAKQFQSHVLELAQISENMTHSLFSKVYTRMVPSSRMMIHQLYTEIMNHliytsnYTNSNgqlgrrgigsv 203
Cdd:pfam01153  83 SSLQTTLTTNHRKFDEFFRELLNISENSLNDMFVRTYGRLYTQNAELFKDLFTELRRY------YRGSN----------- 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647315   204 qSNLEEAVRHFFVQLFPVAYhQMVHLSKnNLGDlheDYVNCLQHNFDEMHPFGDIPQQVQSNLGKSVHMSNVFMNALLQA 283
Cdd:pfam01153 146 -VNLEEALNEFWARLLERLF-KLVNPQY-HFSD---DYLECLSKQTEQLKPFGDVPRKLKLQLTRAFIAARAFVQGLNLG 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647315   284 AEVLSEADALygeQLTDTCKLHLLKMHYCPNCNGHHSssrseTKLCYGYCKNVMRGCSAEYAGlLDSPWSGVVDSLnNLV 363
Cdd:pfam01153 220 REVVNKVSQV---PLSPECTRALMKMLYCPHCRGLPS-----VKPCYNYCLNVMRGCLANQAD-LDTEWRNFIDSL-LLV 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647315   364 TTHILSDTGIINVIKHLQTYFSEAIMAAMHNGPELEKKVKKTCGTPSLTPYSSgEPDARP------------PPHKNNVK 431
Cdd:pfam01153 290 AERLEGPFNIENVIDSIHVKISEAIMNMQENSMKLTAKVFQGCGTPKPTPYRS-TRSSSPeekkkrgfrtytPEERPTTA 368

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647315   432 WATDPDPGMVLFLSTIDKSKEFYTTIVDNFCDEQQHSRDDHS---CWSGDRFGDYTQLLINPGTDSQRYNPEVPFNAKAQ 508
Cdd:pfam01153 369 AGTRLDRLVTDVKEKLKEMKSFWSTLPDTLCSDEKMAADPTNedkCWNGQTKGRYLPEVMGNGLANQINNPEVEVDITKP 448

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647315   509 TGKLNELVDKLFKIRKSIGAAAPSNSIQAtHDIQNDMgegsgggegqIGddeEEYGGAHGSGDGSGDGP------HTPIE 582
Cdd:pfam01153 449 DMVIRQQIMKLKIMTNRLKNAYPGNDVDF-QDDSDDS----------SG---SGSGDGCPSDLCKGDLPfvfeltDTPAT 514

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|
gi 17647315   583 ESEGTTTNEVESRDSGKTSGSNPLEGTATWMLLTLVTMLF 622
Cdd:pfam01153 515 PAKPTTQQGTGSVDGSSTGGLPSSLLLATSMLLSLVTLLV 554
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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