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Conserved domains on  [gi|24663288|ref|NP_524041|]
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twin of eyg, isoform A [Drosophila melanogaster]

Protein Classification

homeobox protein( domain architecture ID 11021495)

homeobox protein with a paired box domain similar to mammalian Pax6, a transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas, and Drosophila gooseberry-neuro, which is involved in defining the polarity of embryonic segments

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
HTH_ARSR super family cl46857
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
134-230 1.44e-37

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


The actual alignment was detected with superfamily member smart00351:

Pssm-ID: 481197 [Multi-domain]  Cd Length: 125  Bit Score: 135.53  E-value: 1.44e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663288    134 HRLLELSRFGLRGYDLAQHMLSQQGAVSKLL------GTLRPpGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRER 207
Cdd:smart00351  24 QRIVELAQNGVRPCDISRQLCVSHGCVSKILgryyetGSIRP-GAIGGSKPKVATPKVVKKIADYKQENPGIFAWEIRDR 102
                           90       100
                   ....*....|....*....|...
gi 24663288    208 LITEGVCTNATAPSVSSINRILR 230
Cdd:smart00351 103 LLSEGVCDKDNVPSVSSINRILR 125
Homeodomain pfam00046
Homeodomain;
385-441 2.46e-28

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 107.59  E-value: 2.46e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 24663288   385 RRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWRR 441
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
 
Name Accession Description Interval E-value
PAX smart00351
Paired Box domain;
134-230 1.44e-37

Paired Box domain;


Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 135.53  E-value: 1.44e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663288    134 HRLLELSRFGLRGYDLAQHMLSQQGAVSKLL------GTLRPpGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRER 207
Cdd:smart00351  24 QRIVELAQNGVRPCDISRQLCVSHGCVSKILgryyetGSIRP-GAIGGSKPKVATPKVVKKIADYKQENPGIFAWEIRDR 102
                           90       100
                   ....*....|....*....|...
gi 24663288    208 LITEGVCTNATAPSVSSINRILR 230
Cdd:smart00351 103 LLSEGVCDKDNVPSVSSINRILR 125
PAX cd00131
Paired Box domain
133-231 1.33e-36

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 133.31  E-value: 1.33e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663288 133 QHRLLELSRFGLRGYDLAQHMLSQQGAVSKLL------GTLRPpGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRE 206
Cdd:cd00131  23 RQRIVELAQSGIRPCDISRQLRVSHGCVSKILnryyetGSIRP-GAIGGSKPRVATPEVVKKIEIYKQENPGMFAWEIRD 101
                        90       100
                ....*....|....*....|....*
gi 24663288 207 RLITEGVCTNATAPSVSSINRILRN 231
Cdd:cd00131 102 RLLQEGVCDKSNVPSVSSINRILRN 126
PAX pfam00292
'Paired box' domain;
133-230 5.49e-34

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 125.75  E-value: 5.49e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663288   133 QHRLLELSRFGLRGYDLAQHMLSQQGAVSKLL------GTLRPpGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRE 206
Cdd:pfam00292  23 RQKIVELAHSGVRPCDISRQLRVSHGCVSKILgryyetGSIRP-GVIGGSKPKVATPEVVTKIAEYKRENPSIFAWEIRD 101
                          90       100
                  ....*....|....*....|....
gi 24663288   207 RLITEGVCTNATAPSVSSINRILR 230
Cdd:pfam00292 102 RLLKEGVCDNDTVPSVSSINRILR 125
Homeodomain pfam00046
Homeodomain;
385-441 2.46e-28

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 107.59  E-value: 2.46e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 24663288   385 RRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWRR 441
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
385-443 3.93e-25

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 98.47  E-value: 3.93e-25
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24663288 385 RRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWRRHQ 443
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
385-440 1.36e-24

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 96.94  E-value: 1.36e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 24663288    385 RRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWR 440
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
346-444 9.02e-13

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 66.31  E-value: 9.02e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663288 346 ALSPDSGSRDSRSPdadANRMIDIEG--EDSESQDSD---------QPKFRRNRTTFSPEQLDELEKEFDKSHYPCVNTR 414
Cdd:COG5576   5 PMQPLSALESQRMP---QIRTIKTTKnkREVEAADSEmklerkqdgSSPPKSKRRRTTDEQLMVLEREFEINPYPSSITR 81
                        90       100       110
                ....*....|....*....|....*....|
gi 24663288 415 EKLAARTALSEARVQVWFSNRRAKWRRHQR 444
Cdd:COG5576  82 IKLSLLLNMPPKSVQIWFQNKRAKEKKKRS 111
 
Name Accession Description Interval E-value
PAX smart00351
Paired Box domain;
134-230 1.44e-37

Paired Box domain;


Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 135.53  E-value: 1.44e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663288    134 HRLLELSRFGLRGYDLAQHMLSQQGAVSKLL------GTLRPpGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRER 207
Cdd:smart00351  24 QRIVELAQNGVRPCDISRQLCVSHGCVSKILgryyetGSIRP-GAIGGSKPKVATPKVVKKIADYKQENPGIFAWEIRDR 102
                           90       100
                   ....*....|....*....|...
gi 24663288    208 LITEGVCTNATAPSVSSINRILR 230
Cdd:smart00351 103 LLSEGVCDKDNVPSVSSINRILR 125
PAX cd00131
Paired Box domain
133-231 1.33e-36

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 133.31  E-value: 1.33e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663288 133 QHRLLELSRFGLRGYDLAQHMLSQQGAVSKLL------GTLRPpGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRE 206
Cdd:cd00131  23 RQRIVELAQSGIRPCDISRQLRVSHGCVSKILnryyetGSIRP-GAIGGSKPRVATPEVVKKIEIYKQENPGMFAWEIRD 101
                        90       100
                ....*....|....*....|....*
gi 24663288 207 RLITEGVCTNATAPSVSSINRILRN 231
Cdd:cd00131 102 RLLQEGVCDKSNVPSVSSINRILRN 126
PAX pfam00292
'Paired box' domain;
133-230 5.49e-34

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 125.75  E-value: 5.49e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663288   133 QHRLLELSRFGLRGYDLAQHMLSQQGAVSKLL------GTLRPpGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRE 206
Cdd:pfam00292  23 RQKIVELAHSGVRPCDISRQLRVSHGCVSKILgryyetGSIRP-GVIGGSKPKVATPEVVTKIAEYKRENPSIFAWEIRD 101
                          90       100
                  ....*....|....*....|....
gi 24663288   207 RLITEGVCTNATAPSVSSINRILR 230
Cdd:pfam00292 102 RLLKEGVCDNDTVPSVSSINRILR 125
Homeodomain pfam00046
Homeodomain;
385-441 2.46e-28

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 107.59  E-value: 2.46e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 24663288   385 RRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWRR 441
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
385-443 3.93e-25

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 98.47  E-value: 3.93e-25
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24663288 385 RRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWRRHQ 443
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
385-440 1.36e-24

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 96.94  E-value: 1.36e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 24663288    385 RRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWR 440
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
346-444 9.02e-13

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 66.31  E-value: 9.02e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663288 346 ALSPDSGSRDSRSPdadANRMIDIEG--EDSESQDSD---------QPKFRRNRTTFSPEQLDELEKEFDKSHYPCVNTR 414
Cdd:COG5576   5 PMQPLSALESQRMP---QIRTIKTTKnkREVEAADSEmklerkqdgSSPPKSKRRRTTDEQLMVLEREFEINPYPSSITR 81
                        90       100       110
                ....*....|....*....|....*....|
gi 24663288 415 EKLAARTALSEARVQVWFSNRRAKWRRHQR 444
Cdd:COG5576  82 IKLSLLLNMPPKSVQIWFQNKRAKEKKKRS 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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