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Conserved domains on  [gi|17647987|ref|NP_524102|]
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TBP-associated factor 4, isoform A [Drosophila melanogaster]

Protein Classification

TAFH and TAF4 domain-containing protein( domain architecture ID 11272950)

TAFH and TAF4 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TAF4 pfam05236
Transcription initiation factor TFIID component TAF4 family; This region of similarity is ...
 675-917 4.05e-99

Transcription initiation factor TFIID component TAF4 family; This region of similarity is found in Transcription initiation factor TFIID component TAF4.


:

Pssm-ID: 461598 [Multi-domain]  Cd Length: 264  Bit Score: 310.74  E-value: 4.05e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647987   675 INDVAAMGGVNLAEESQRILGC------TENIGTQIRSCKDEVFLNLPSLQARIRAITSEAGLDEPSQDVAVLISHACQE 748
Cdd:pfam05236   1 LNDVLAMAGVNLREEEERLLSSqeastnSEAVGTVVRSCKDEPFLNPYPLQRKILEIAKKNGLKEIDPDVLELLSHACEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647987   749 RLKNIVEKLAVIAEHRIDVIKLDPRYEPAKDVRGQIKFLEELDKAEQKRHEELEREMLLRAAKSRSRVEDPEQAKMKARA 828
Cdd:pfam05236  81 RLRNLLEKLIVISRHRRDGEKTDHRYEQTSDVRKQLKFLAQKDKEEEERRVAEEREGLLKAAKSRSNQEDPEQLKLKQEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647987   829 KEMQRAEMEELRQRDANLTALQAIGPRKKLKLD--------------GETVSSGAGSSGGGVLSSSGSAPTTLRPRIKRV 894
Cdd:pfam05236 161 KEMQKEEDEKMRHRAANLTALAAIGPRKKKYSWmsssasgsggggsgSSKPSSSSGSSSKGTSQTQSSAISREARRIKRV 240

                         250       260
                  ....*....|....*....|...
gi 17647987   895 NLRDMLFYMEQEREFCRSSMLFK 917
Cdd:pfam05236 241 TLRDLLFALEQEREGSRSALLYG 263
TAFH smart00549
TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila ...
 293-383 3.39e-37

TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila TAF110. Also known as nervy homology region 1 (NHR1).


:

Pssm-ID: 197785 [Multi-domain]  Cd Length: 92  Bit Score: 134.51  E-value: 3.39e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647987    293 TKEKCRKFLANLIELSTREPKP-VEKNVRTLIQELVNANVEPEEFCDRLERLLNASPQPCLIGFLKKSLPLLRQALYTKE 371
Cdd:smart00549   1 NVSKCKRFLTTLIQLSNDISQPeVAERVRTLVLGLVNGTITAEEFTSRLQEALNSPLQPYLIPFLKNSLPLLRRELLHCA 80

                           90
                   ....*....|..
gi 17647987    372 LVIEGIKPPPQH 383
Cdd:smart00549  81 RLIEQSPPQPLA 92
 
Name Accession Description Interval E-value
TAF4 pfam05236
Transcription initiation factor TFIID component TAF4 family; This region of similarity is ...
 675-917 4.05e-99

Transcription initiation factor TFIID component TAF4 family; This region of similarity is found in Transcription initiation factor TFIID component TAF4.


Pssm-ID: 461598 [Multi-domain]  Cd Length: 264  Bit Score: 310.74  E-value: 4.05e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647987   675 INDVAAMGGVNLAEESQRILGC------TENIGTQIRSCKDEVFLNLPSLQARIRAITSEAGLDEPSQDVAVLISHACQE 748
Cdd:pfam05236   1 LNDVLAMAGVNLREEEERLLSSqeastnSEAVGTVVRSCKDEPFLNPYPLQRKILEIAKKNGLKEIDPDVLELLSHACEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647987   749 RLKNIVEKLAVIAEHRIDVIKLDPRYEPAKDVRGQIKFLEELDKAEQKRHEELEREMLLRAAKSRSRVEDPEQAKMKARA 828
Cdd:pfam05236  81 RLRNLLEKLIVISRHRRDGEKTDHRYEQTSDVRKQLKFLAQKDKEEEERRVAEEREGLLKAAKSRSNQEDPEQLKLKQEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647987   829 KEMQRAEMEELRQRDANLTALQAIGPRKKLKLD--------------GETVSSGAGSSGGGVLSSSGSAPTTLRPRIKRV 894
Cdd:pfam05236 161 KEMQKEEDEKMRHRAANLTALAAIGPRKKKYSWmsssasgsggggsgSSKPSSSSGSSSKGTSQTQSSAISREARRIKRV 240

                         250       260
                  ....*....|....*....|...
gi 17647987   895 NLRDMLFYMEQEREFCRSSMLFK 917
Cdd:pfam05236 241 TLRDLLFALEQEREGSRSALLYG 263
TAFH smart00549
TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila ...
 293-383 3.39e-37

TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila TAF110. Also known as nervy homology region 1 (NHR1).


Pssm-ID: 197785 [Multi-domain]  Cd Length: 92  Bit Score: 134.51  E-value: 3.39e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647987    293 TKEKCRKFLANLIELSTREPKP-VEKNVRTLIQELVNANVEPEEFCDRLERLLNASPQPCLIGFLKKSLPLLRQALYTKE 371
Cdd:smart00549   1 NVSKCKRFLTTLIQLSNDISQPeVAERVRTLVLGLVNGTITAEEFTSRLQEALNSPLQPYLIPFLKNSLPLLRRELLHCA 80

                           90
                   ....*....|..
gi 17647987    372 LVIEGIKPPPQH 383
Cdd:smart00549  81 RLIEQSPPQPLA 92
HFD_TAF4 cd08045
histone-fold domain found in transcription initiation factor TFIID subunit 4 (TAF4) and ...
 709-808 3.72e-36

histone-fold domain found in transcription initiation factor TFIID subunit 4 (TAF4) and similar proteins; TAF4, also called TATA Binding Protein (TBP) associated factor 4, RNA polymerase II TBP-associated factor subunit C, TBP-associated factor 4, transcription initiation factor TFIID 130 kDa subunit (TAF(II)130, TAFII-130, TAFII130), or transcription initiation factor TFIID 135 kDa subunit (TAF(II)135, TAFII-135, TAFII135), is a component of the TFIID complex that is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TFIID is one of the general transcription factors required for accurate and regulated initiation by RNA polymerase II. It plays a central role in mediating promoter responses to various activators and repressors. TAF4 potentiates transcriptional activation by the AF-2S of retinoic acid, vitamin D3 and thyroid hormone. TAF4 also acts as a component of the TFTC-HAT complex and some MLL1/MLL complexes. TAF4 interacts with ATF7 and the interaction inhibits ATF7-mediated transactivation.


Pssm-ID: 467027 [Multi-domain]  Cd Length: 100  Bit Score: 131.58  E-value: 3.72e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647987 709 DEVFLNLPSLQARIRAITSEAGLDEPSQDVAVLISHACQERLKNIVEKLAVIAEHRIDVIKLDPRYEPAKDVRGQIKFLE 788
Cdd:cd08045   1 EESFLNPPPLQKKIQKIAKKHGLKEVSPDVLSLLSLAVQERLRDLLEKLIVASKHRVDSEKPDYRYEVTSDVRRQLKALE 80

                        90       100
                ....*....|....*....|
gi 17647987 789 ELDKAEQKRHEELEREMLLR 808
Cdd:cd08045  81 RLEREEEERRREEERERLLR 100
TAFH pfam07531
NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the ...
 293-381 2.65e-34

NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the product of the nervy gene in Drosophila and the human mtg8b protein, which is hypothesized to be a transcription factor.


Pssm-ID: 462195  Cd Length: 90  Bit Score: 126.23  E-value: 2.65e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647987   293 TKEKCRKFLANLIELSTREPKPVEKNVRTLIQELVNANVEPEEFCDRLERLLNASPQPCLIGFLKKSLPLLRQALYTKEL 372
Cdd:pfam07531   1 NVKKCKNFLSTLIKLAGEQSPETGENVKELVQGLLNGKIEPEEFTSKLQEELNSSPQPYLVPFLKKSLPALRQELLNSAR 80


                  ....*....
gi 17647987   373 VIEGIKPPP 381
Cdd:pfam07531  81 FIQQCPPQY 89
 
Name Accession Description Interval E-value
TAF4 pfam05236
Transcription initiation factor TFIID component TAF4 family; This region of similarity is ...
 675-917 4.05e-99

Transcription initiation factor TFIID component TAF4 family; This region of similarity is found in Transcription initiation factor TFIID component TAF4.


Pssm-ID: 461598 [Multi-domain]  Cd Length: 264  Bit Score: 310.74  E-value: 4.05e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647987   675 INDVAAMGGVNLAEESQRILGC------TENIGTQIRSCKDEVFLNLPSLQARIRAITSEAGLDEPSQDVAVLISHACQE 748
Cdd:pfam05236   1 LNDVLAMAGVNLREEEERLLSSqeastnSEAVGTVVRSCKDEPFLNPYPLQRKILEIAKKNGLKEIDPDVLELLSHACEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647987   749 RLKNIVEKLAVIAEHRIDVIKLDPRYEPAKDVRGQIKFLEELDKAEQKRHEELEREMLLRAAKSRSRVEDPEQAKMKARA 828
Cdd:pfam05236  81 RLRNLLEKLIVISRHRRDGEKTDHRYEQTSDVRKQLKFLAQKDKEEEERRVAEEREGLLKAAKSRSNQEDPEQLKLKQEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647987   829 KEMQRAEMEELRQRDANLTALQAIGPRKKLKLD--------------GETVSSGAGSSGGGVLSSSGSAPTTLRPRIKRV 894
Cdd:pfam05236 161 KEMQKEEDEKMRHRAANLTALAAIGPRKKKYSWmsssasgsggggsgSSKPSSSSGSSSKGTSQTQSSAISREARRIKRV 240

                         250       260
                  ....*....|....*....|...
gi 17647987   895 NLRDMLFYMEQEREFCRSSMLFK 917
Cdd:pfam05236 241 TLRDLLFALEQEREGSRSALLYG 263
TAFH smart00549
TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila ...
 293-383 3.39e-37

TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila TAF110. Also known as nervy homology region 1 (NHR1).


Pssm-ID: 197785 [Multi-domain]  Cd Length: 92  Bit Score: 134.51  E-value: 3.39e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647987    293 TKEKCRKFLANLIELSTREPKP-VEKNVRTLIQELVNANVEPEEFCDRLERLLNASPQPCLIGFLKKSLPLLRQALYTKE 371
Cdd:smart00549   1 NVSKCKRFLTTLIQLSNDISQPeVAERVRTLVLGLVNGTITAEEFTSRLQEALNSPLQPYLIPFLKNSLPLLRRELLHCA 80

                           90
                   ....*....|..
gi 17647987    372 LVIEGIKPPPQH 383
Cdd:smart00549  81 RLIEQSPPQPLA 92
HFD_TAF4 cd08045
histone-fold domain found in transcription initiation factor TFIID subunit 4 (TAF4) and ...
 709-808 3.72e-36

histone-fold domain found in transcription initiation factor TFIID subunit 4 (TAF4) and similar proteins; TAF4, also called TATA Binding Protein (TBP) associated factor 4, RNA polymerase II TBP-associated factor subunit C, TBP-associated factor 4, transcription initiation factor TFIID 130 kDa subunit (TAF(II)130, TAFII-130, TAFII130), or transcription initiation factor TFIID 135 kDa subunit (TAF(II)135, TAFII-135, TAFII135), is a component of the TFIID complex that is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TFIID is one of the general transcription factors required for accurate and regulated initiation by RNA polymerase II. It plays a central role in mediating promoter responses to various activators and repressors. TAF4 potentiates transcriptional activation by the AF-2S of retinoic acid, vitamin D3 and thyroid hormone. TAF4 also acts as a component of the TFTC-HAT complex and some MLL1/MLL complexes. TAF4 interacts with ATF7 and the interaction inhibits ATF7-mediated transactivation.


Pssm-ID: 467027 [Multi-domain]  Cd Length: 100  Bit Score: 131.58  E-value: 3.72e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647987 709 DEVFLNLPSLQARIRAITSEAGLDEPSQDVAVLISHACQERLKNIVEKLAVIAEHRIDVIKLDPRYEPAKDVRGQIKFLE 788
Cdd:cd08045   1 EESFLNPPPLQKKIQKIAKKHGLKEVSPDVLSLLSLAVQERLRDLLEKLIVASKHRVDSEKPDYRYEVTSDVRRQLKALE 80

                        90       100
                ....*....|....*....|
gi 17647987 789 ELDKAEQKRHEELEREMLLR 808
Cdd:cd08045  81 RLEREEEERRREEERERLLR 100
TAFH pfam07531
NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the ...
 293-381 2.65e-34

NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the product of the nervy gene in Drosophila and the human mtg8b protein, which is hypothesized to be a transcription factor.


Pssm-ID: 462195  Cd Length: 90  Bit Score: 126.23  E-value: 2.65e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647987   293 TKEKCRKFLANLIELSTREPKPVEKNVRTLIQELVNANVEPEEFCDRLERLLNASPQPCLIGFLKKSLPLLRQALYTKEL 372
Cdd:pfam07531   1 NVKKCKNFLSTLIKLAGEQSPETGENVKELVQGLLNGKIEPEEFTSKLQEELNSSPQPYLVPFLKKSLPALRQELLNSAR 80


                  ....*....
gi 17647987   373 VIEGIKPPP 381
Cdd:pfam07531  81 FIQQCPPQY 89
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 755-843 1.99e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.03  E-value: 1.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647987   755 EKLAVIAEHRIDVIKLDPRYEPAKDVRGQ--------IKFLEELDKAEQKRHEELEREmlLRAAKSRSRVEDPEQAKMKA 826
Cdd:pfam17380 340 ERMAMERERELERIRQEERKRELERIRQEeiameisrMRELERLQMERQQKNERVRQE--LEAARKVKILEEERQRKIQQ 417

                          90
                  ....*....|....*....
gi 17647987   827 RAKEMQ--RAEMEELRQRD 843
Cdd:pfam17380 418 QKVEMEqiRAEQEEARQRE 436
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 787-842 8.33e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 39.52  E-value: 8.33e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 17647987   787 LEELD-KAEQKRHEELEREMLLRAAKSRSRVEdpeQAKMKARAKEMQRAEMEELRQR 842
Cdd:pfam13868 212 QEEQErKERQKEREEAEKKARQRQELQQAREE---QIELKERRLAEEAEREEEEFER 265
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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