|
Name |
Accession |
Description |
Interval |
E-value |
| Importin_rep_6 |
pfam18829 |
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
766-875 |
1.25e-39 |
|
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry represents two consecutive repeat units and includes sequences captured by pfam18808.
:
Pssm-ID: 465881 Cd Length: 110 Bit Score: 142.24 E-value: 1.25e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 766 VQSELLNSLAKCIETLGPNCLNEDAMKQVLEIINKYVLEHFERADKRLAARNEEDYDDGVEEELAEQDDTDVYILSKIVD 845
Cdd:pfam18829 1 VLAEYYSSLAECIEVLGPNCLSDEQMEEFIKAINSNLTEYFERVKEREEERKDDDYDEEVEEDLEEEEETDEELLSEINK 80
|
90 100 110
....*....|....*....|....*....|
gi 17737759 846 ITHALFQTNKAQFLPAFEQVAPHFVKLLEP 875
Cdd:pfam18829 81 AIHAIFKTHKTAFLPYFEQLLPTVVAFLND 110
|
|
| Importin_rep_4 |
pfam18808 |
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
268-358 |
2.25e-31 |
|
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit.
:
Pssm-ID: 408579 Cd Length: 90 Bit Score: 117.95 E-value: 2.25e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 268 SQDFEDSWRHLVLEVMVSLAENAPSMIRKRAdKYIVALIPLILHMMTDLDDDENWSTADVVDDDDHSDNNVIAESSLDRL 347
Cdd:pfam18808 1 NKDLDDAARQVALELLVTLAEAAPGMCRKQP-QFTNALVPICLSMMTEVDDAEDWYTSDDLDDDDNEDNYVFGEQALDRL 79
|
90
....*....|.
gi 17737759 348 ACGLGGKIVLP 358
Cdd:pfam18808 80 ACRLGGKALLP 90
|
|
| KAP95 super family |
cl27231 |
Karyopherin (importin) beta [Intracellular trafficking and secretion]; |
6-625 |
1.33e-10 |
|
Karyopherin (importin) beta [Intracellular trafficking and secretion];
The actual alignment was detected with superfamily member COG5215:
Pssm-ID: 227540 [Multi-domain] Cd Length: 858 Bit Score: 65.73 E-value: 1.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 6 AHFQQLLA-SLLSTDNDVRQQAEEAYNNLSRE--LKVTHLLGNI-QNGQQSEEARQMAAVLLRRLFTT-------EFFDF 74
Cdd:COG5215 4 SEFRCLGKnHVLSPDPNARLRAEAQLLELQSGdfEQFISLLVQVlCDLNSNDQLRMVAGLILKNSLHAndpelqkGCSQR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 75 YKGLPAESQNQLLQQILLAVQQEVtPQLRRKICEVVAEVARNlidEDCNNQWPDILQFLFQ--CANSPTPQLQESALRI- 151
Cdd:COG5215 84 WLGMRHESKEQVKGMALRALKSPE-PRFCTMAAQLLAAIARM---ELPNSLWPGLMEEMVRnvGDEQPVSGKCESLGICg 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 152 ---FSSVPSIFgnqEAQYIDLIKQMLAKSMDAGSDPEVRVQAVRAVGAFILY---------------------HDKENET 207
Cdd:COG5215 160 yhcESEAPEDL---IQMSNVILFAIVMGALKNETTSAVRLAALKALMDSLMFvqgnfcyeeernyfmqvvceaTQGNDEE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 208 AIHKHFAdMLPRMIHITGETIEAQDDQSLLKLLIEMTENCPKFLRPQ-LEFIFEVCMKvfssqdfedswrHLVLEVMVSL 286
Cdd:COG5215 237 LQHAAFG-CLNKIMMLYYKFMQSYMENALAALTGRFMKSQNDEVAIQaVEFWSTICEE------------EIDGEMEDKY 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 287 AENAPSMIRKRADKYIVALIPLILHMMTDLD---DDENWSTADVvddddhsdnnviAESSLDRLACGLGGKIVLPlVMNA 363
Cdd:COG5215 304 LPEVPAQNHGFARAAVADVLPELLSLLEKQGedyYGDDWNPSMA------------ASSCLQLFAQLKGDKIMRP-VLGF 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 364 LPVMLGHADWKHRFAALMAISAIGEG-CHKQMEAILDEVMSGVLNFLSDPHPRVRYAACNAIGQMSTDFAQTFEKKFHsq 442
Cdd:COG5215 371 VEQNIRSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGH-- 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 443 vIPGLLS--LLDDVENPRVQAHAGAALVNFSEDCPKniLTRYLDGIMAKL-ETILNSKFKELVEKGNKLVL--------- 510
Cdd:COG5215 449 -LVLEVSasLIGLMDCPFRSINCSWRKENLVDHIAK--AVREVESFLAKFyLAILNALVKGTELALNESNLrvslfsalg 525
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 511 EQVVTTIASVADTCESEFVAYYDRLMPCLKFIIQNANSDDLRMLRGKTIECVSLIGLAVgrEKFIGDAGEVMDMLLVNHT 590
Cdd:COG5215 526 TLILICPDAVSDILAGFYDYTSKKLDECISVLGQILATEDQLLVEELQSNYIGVLEAII--RTRRRDIEDVEDQLMELFI 603
|
650 660 670
....*....|....*....|....*....|....*
gi 17737759 591 EGGELADDDPQTSYLITAWARMCKILGKQFEQYLP 625
Cdd:COG5215 604 RILESTKPTTAFGDVYTAISALSTSLEERFEQYAS 638
|
|
| Importin_rep_5 super family |
cl40106 |
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
1007-1059 |
2.08e-05 |
|
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit and includes sequences not captured by pfam18808.
The actual alignment was detected with superfamily member pfam18816:
Pssm-ID: 465877 Cd Length: 52 Bit Score: 42.85 E-value: 2.08e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 17737759 1007 DSEEAAHIYGYLCDLIEGNHPVILgannGNLPRIVSIIAESFCTKVVEAQSAT 1059
Cdd:pfam18816 1 DEEAAPFAYRFLAELIEQNHPAVT----SQIPKVVDSVVQALEHKSLSGKTAE 49
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Importin_rep_6 |
pfam18829 |
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
766-875 |
1.25e-39 |
|
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry represents two consecutive repeat units and includes sequences captured by pfam18808.
Pssm-ID: 465881 Cd Length: 110 Bit Score: 142.24 E-value: 1.25e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 766 VQSELLNSLAKCIETLGPNCLNEDAMKQVLEIINKYVLEHFERADKRLAARNEEDYDDGVEEELAEQDDTDVYILSKIVD 845
Cdd:pfam18829 1 VLAEYYSSLAECIEVLGPNCLSDEQMEEFIKAINSNLTEYFERVKEREEERKDDDYDEEVEEDLEEEEETDEELLSEINK 80
|
90 100 110
....*....|....*....|....*....|
gi 17737759 846 ITHALFQTNKAQFLPAFEQVAPHFVKLLEP 875
Cdd:pfam18829 81 AIHAIFKTHKTAFLPYFEQLLPTVVAFLND 110
|
|
| Importin_rep_4 |
pfam18808 |
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
268-358 |
2.25e-31 |
|
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit.
Pssm-ID: 408579 Cd Length: 90 Bit Score: 117.95 E-value: 2.25e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 268 SQDFEDSWRHLVLEVMVSLAENAPSMIRKRAdKYIVALIPLILHMMTDLDDDENWSTADVVDDDDHSDNNVIAESSLDRL 347
Cdd:pfam18808 1 NKDLDDAARQVALELLVTLAEAAPGMCRKQP-QFTNALVPICLSMMTEVDDAEDWYTSDDLDDDDNEDNYVFGEQALDRL 79
|
90
....*....|.
gi 17737759 348 ACGLGGKIVLP 358
Cdd:pfam18808 80 ACRLGGKALLP 90
|
|
| KAP95 |
COG5215 |
Karyopherin (importin) beta [Intracellular trafficking and secretion]; |
6-625 |
1.33e-10 |
|
Karyopherin (importin) beta [Intracellular trafficking and secretion];
Pssm-ID: 227540 [Multi-domain] Cd Length: 858 Bit Score: 65.73 E-value: 1.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 6 AHFQQLLA-SLLSTDNDVRQQAEEAYNNLSRE--LKVTHLLGNI-QNGQQSEEARQMAAVLLRRLFTT-------EFFDF 74
Cdd:COG5215 4 SEFRCLGKnHVLSPDPNARLRAEAQLLELQSGdfEQFISLLVQVlCDLNSNDQLRMVAGLILKNSLHAndpelqkGCSQR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 75 YKGLPAESQNQLLQQILLAVQQEVtPQLRRKICEVVAEVARNlidEDCNNQWPDILQFLFQ--CANSPTPQLQESALRI- 151
Cdd:COG5215 84 WLGMRHESKEQVKGMALRALKSPE-PRFCTMAAQLLAAIARM---ELPNSLWPGLMEEMVRnvGDEQPVSGKCESLGICg 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 152 ---FSSVPSIFgnqEAQYIDLIKQMLAKSMDAGSDPEVRVQAVRAVGAFILY---------------------HDKENET 207
Cdd:COG5215 160 yhcESEAPEDL---IQMSNVILFAIVMGALKNETTSAVRLAALKALMDSLMFvqgnfcyeeernyfmqvvceaTQGNDEE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 208 AIHKHFAdMLPRMIHITGETIEAQDDQSLLKLLIEMTENCPKFLRPQ-LEFIFEVCMKvfssqdfedswrHLVLEVMVSL 286
Cdd:COG5215 237 LQHAAFG-CLNKIMMLYYKFMQSYMENALAALTGRFMKSQNDEVAIQaVEFWSTICEE------------EIDGEMEDKY 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 287 AENAPSMIRKRADKYIVALIPLILHMMTDLD---DDENWSTADVvddddhsdnnviAESSLDRLACGLGGKIVLPlVMNA 363
Cdd:COG5215 304 LPEVPAQNHGFARAAVADVLPELLSLLEKQGedyYGDDWNPSMA------------ASSCLQLFAQLKGDKIMRP-VLGF 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 364 LPVMLGHADWKHRFAALMAISAIGEG-CHKQMEAILDEVMSGVLNFLSDPHPRVRYAACNAIGQMSTDFAQTFEKKFHsq 442
Cdd:COG5215 371 VEQNIRSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGH-- 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 443 vIPGLLS--LLDDVENPRVQAHAGAALVNFSEDCPKniLTRYLDGIMAKL-ETILNSKFKELVEKGNKLVL--------- 510
Cdd:COG5215 449 -LVLEVSasLIGLMDCPFRSINCSWRKENLVDHIAK--AVREVESFLAKFyLAILNALVKGTELALNESNLrvslfsalg 525
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 511 EQVVTTIASVADTCESEFVAYYDRLMPCLKFIIQNANSDDLRMLRGKTIECVSLIGLAVgrEKFIGDAGEVMDMLLVNHT 590
Cdd:COG5215 526 TLILICPDAVSDILAGFYDYTSKKLDECISVLGQILATEDQLLVEELQSNYIGVLEAII--RTRRRDIEDVEDQLMELFI 603
|
650 660 670
....*....|....*....|....*....|....*
gi 17737759 591 EGGELADDDPQTSYLITAWARMCKILGKQFEQYLP 625
Cdd:COG5215 604 RILESTKPTTAFGDVYTAISALSTSLEERFEQYAS 638
|
|
| HEAT_EZ |
pfam13513 |
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ... |
373-427 |
2.45e-09 |
|
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.
Pssm-ID: 463906 [Multi-domain] Cd Length: 55 Bit Score: 53.91 E-value: 2.45e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 17737759 373 WKHRFAALMAISAIGEGCHKQMEAILDEVMSGVLNFLSDPHPRVRYAACNAIGQM 427
Cdd:pfam13513 1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
|
|
| Importin_rep_5 |
pfam18816 |
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
1007-1059 |
2.08e-05 |
|
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit and includes sequences not captured by pfam18808.
Pssm-ID: 465877 Cd Length: 52 Bit Score: 42.85 E-value: 2.08e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 17737759 1007 DSEEAAHIYGYLCDLIEGNHPVILgannGNLPRIVSIIAESFCTKVVEAQSAT 1059
Cdd:pfam18816 1 DEEAAPFAYRFLAELIEQNHPAVT----SQIPKVVDSVVQALEHKSLSGKTAE 49
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Importin_rep_6 |
pfam18829 |
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
766-875 |
1.25e-39 |
|
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry represents two consecutive repeat units and includes sequences captured by pfam18808.
Pssm-ID: 465881 Cd Length: 110 Bit Score: 142.24 E-value: 1.25e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 766 VQSELLNSLAKCIETLGPNCLNEDAMKQVLEIINKYVLEHFERADKRLAARNEEDYDDGVEEELAEQDDTDVYILSKIVD 845
Cdd:pfam18829 1 VLAEYYSSLAECIEVLGPNCLSDEQMEEFIKAINSNLTEYFERVKEREEERKDDDYDEEVEEDLEEEEETDEELLSEINK 80
|
90 100 110
....*....|....*....|....*....|
gi 17737759 846 ITHALFQTNKAQFLPAFEQVAPHFVKLLEP 875
Cdd:pfam18829 81 AIHAIFKTHKTAFLPYFEQLLPTVVAFLND 110
|
|
| Importin_rep_4 |
pfam18808 |
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
268-358 |
2.25e-31 |
|
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit.
Pssm-ID: 408579 Cd Length: 90 Bit Score: 117.95 E-value: 2.25e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 268 SQDFEDSWRHLVLEVMVSLAENAPSMIRKRAdKYIVALIPLILHMMTDLDDDENWSTADVVDDDDHSDNNVIAESSLDRL 347
Cdd:pfam18808 1 NKDLDDAARQVALELLVTLAEAAPGMCRKQP-QFTNALVPICLSMMTEVDDAEDWYTSDDLDDDDNEDNYVFGEQALDRL 79
|
90
....*....|.
gi 17737759 348 ACGLGGKIVLP 358
Cdd:pfam18808 80 ACRLGGKALLP 90
|
|
| KAP95 |
COG5215 |
Karyopherin (importin) beta [Intracellular trafficking and secretion]; |
6-625 |
1.33e-10 |
|
Karyopherin (importin) beta [Intracellular trafficking and secretion];
Pssm-ID: 227540 [Multi-domain] Cd Length: 858 Bit Score: 65.73 E-value: 1.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 6 AHFQQLLA-SLLSTDNDVRQQAEEAYNNLSRE--LKVTHLLGNI-QNGQQSEEARQMAAVLLRRLFTT-------EFFDF 74
Cdd:COG5215 4 SEFRCLGKnHVLSPDPNARLRAEAQLLELQSGdfEQFISLLVQVlCDLNSNDQLRMVAGLILKNSLHAndpelqkGCSQR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 75 YKGLPAESQNQLLQQILLAVQQEVtPQLRRKICEVVAEVARNlidEDCNNQWPDILQFLFQ--CANSPTPQLQESALRI- 151
Cdd:COG5215 84 WLGMRHESKEQVKGMALRALKSPE-PRFCTMAAQLLAAIARM---ELPNSLWPGLMEEMVRnvGDEQPVSGKCESLGICg 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 152 ---FSSVPSIFgnqEAQYIDLIKQMLAKSMDAGSDPEVRVQAVRAVGAFILY---------------------HDKENET 207
Cdd:COG5215 160 yhcESEAPEDL---IQMSNVILFAIVMGALKNETTSAVRLAALKALMDSLMFvqgnfcyeeernyfmqvvceaTQGNDEE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 208 AIHKHFAdMLPRMIHITGETIEAQDDQSLLKLLIEMTENCPKFLRPQ-LEFIFEVCMKvfssqdfedswrHLVLEVMVSL 286
Cdd:COG5215 237 LQHAAFG-CLNKIMMLYYKFMQSYMENALAALTGRFMKSQNDEVAIQaVEFWSTICEE------------EIDGEMEDKY 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 287 AENAPSMIRKRADKYIVALIPLILHMMTDLD---DDENWSTADVvddddhsdnnviAESSLDRLACGLGGKIVLPlVMNA 363
Cdd:COG5215 304 LPEVPAQNHGFARAAVADVLPELLSLLEKQGedyYGDDWNPSMA------------ASSCLQLFAQLKGDKIMRP-VLGF 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 364 LPVMLGHADWKHRFAALMAISAIGEG-CHKQMEAILDEVMSGVLNFLSDPHPRVRYAACNAIGQMSTDFAQTFEKKFHsq 442
Cdd:COG5215 371 VEQNIRSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGH-- 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 443 vIPGLLS--LLDDVENPRVQAHAGAALVNFSEDCPKniLTRYLDGIMAKL-ETILNSKFKELVEKGNKLVL--------- 510
Cdd:COG5215 449 -LVLEVSasLIGLMDCPFRSINCSWRKENLVDHIAK--AVREVESFLAKFyLAILNALVKGTELALNESNLrvslfsalg 525
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 511 EQVVTTIASVADTCESEFVAYYDRLMPCLKFIIQNANSDDLRMLRGKTIECVSLIGLAVgrEKFIGDAGEVMDMLLVNHT 590
Cdd:COG5215 526 TLILICPDAVSDILAGFYDYTSKKLDECISVLGQILATEDQLLVEELQSNYIGVLEAII--RTRRRDIEDVEDQLMELFI 603
|
650 660 670
....*....|....*....|....*....|....*
gi 17737759 591 EGGELADDDPQTSYLITAWARMCKILGKQFEQYLP 625
Cdd:COG5215 604 RILESTKPTTAFGDVYTAISALSTSLEERFEQYAS 638
|
|
| HEAT_EZ |
pfam13513 |
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ... |
373-427 |
2.45e-09 |
|
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.
Pssm-ID: 463906 [Multi-domain] Cd Length: 55 Bit Score: 53.91 E-value: 2.45e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 17737759 373 WKHRFAALMAISAIGEGCHKQMEAILDEVMSGVLNFLSDPHPRVRYAACNAIGQM 427
Cdd:pfam13513 1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
|
|
| HEAT_2 |
pfam13646 |
HEAT repeats; This family includes multiple HEAT repeats. |
364-467 |
1.11e-08 |
|
HEAT repeats; This family includes multiple HEAT repeats.
Pssm-ID: 433376 [Multi-domain] Cd Length: 88 Bit Score: 53.11 E-value: 1.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 364 LPVMLGHADWKHRFAALMAISAIGEgchkqmeailDEVMSGVLNFLSDPHPRVRYAACNAIGQMSTdfaqtfekkfhSQV 443
Cdd:pfam13646 5 LQALLRDPDPEVRAAAIRALGRIGD----------PEAVPALLELLKDEDPAVRRAAAEALGKIGD-----------PEA 63
|
90 100
....*....|....*....|....
gi 17737759 444 IPGLLSLLDDVENPRVQAHAGAAL 467
Cdd:pfam13646 64 LPALLELLRDDDDDVVRAAAAEAL 87
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
351-484 |
1.38e-06 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 48.86 E-value: 1.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 351 LGGKIVLPLVMNALpvmlGHADWKHRFAALMAISAIGEgchkqmeailDEVMSGVLNFLSDPHPRVRYAACNAIGQMSTD 430
Cdd:COG1413 12 LGDPAAVPALIAAL----ADEDPDVRAAAARALGRLGD----------PRAVPALLEALKDPDPEVRAAAAEALGRIGDP 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 17737759 431 faqtfekkfhsQVIPGLLSLLDDvENPRVQAHAGAALVNFSEDCPKNILTRYLD 484
Cdd:COG1413 78 -----------EAVPALIAALKD-EDPEVRRAAAEALGRLGDPAAVPALLEALK 119
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
351-467 |
2.36e-06 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 48.09 E-value: 2.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 351 LGGKIVLPLVMNALpvmlGHADWKHRFAALMAISAIGEgchkqmeailDEVMSGVLNFLSDPHPRVRYAACNAIGQMSTD 430
Cdd:COG1413 43 LGDPRAVPALLEAL----KDPDPEVRAAAAEALGRIGD----------PEAVPALIAALKDEDPEVRRAAAEALGRLGDP 108
|
90 100 110
....*....|....*....|....*....|....*..
gi 17737759 431 faqtfekkfhsQVIPGLLSLLDDvENPRVQAHAGAAL 467
Cdd:COG1413 109 -----------AAVPALLEALKD-PDWEVRRAAARAL 133
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
376-484 |
9.81e-06 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 46.16 E-value: 9.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 376 RFAALMAISAIGEgchkqmeailDEVMSGVLNFLSDPHPRVRYAACNAIGQMStdfaqtfekkfHSQVIPGLLSLLDDvE 455
Cdd:COG1413 2 RRAAARALGRLGD----------PAAVPALIAALADEDPDVRAAAARALGRLG-----------DPRAVPALLEALKD-P 59
|
90 100
....*....|....*....|....*....
gi 17737759 456 NPRVQAHAGAALVNFSEDCPKNILTRYLD 484
Cdd:COG1413 60 DPEVRAAAAEALGRIGDPEAVPALIAALK 88
|
|
| Importin_rep_5 |
pfam18816 |
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
1007-1059 |
2.08e-05 |
|
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit and includes sequences not captured by pfam18808.
Pssm-ID: 465877 Cd Length: 52 Bit Score: 42.85 E-value: 2.08e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 17737759 1007 DSEEAAHIYGYLCDLIEGNHPVILgannGNLPRIVSIIAESFCTKVVEAQSAT 1059
Cdd:pfam18816 1 DEEAAPFAYRFLAELIEQNHPAVT----SQIPKVVDSVVQALEHKSLSGKTAE 49
|
|
| HEAT_2 |
pfam13646 |
HEAT repeats; This family includes multiple HEAT repeats. |
409-484 |
3.18e-04 |
|
HEAT repeats; This family includes multiple HEAT repeats.
Pssm-ID: 433376 [Multi-domain] Cd Length: 88 Bit Score: 40.78 E-value: 3.18e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17737759 409 LSDPHPRVRYAACNAIGQMStdfaqtfekkfHSQVIPGLLSLLDDvENPRVQAHAGAALVNFSEDCPKNILTRYLD 484
Cdd:pfam13646 9 LRDPDPEVRAAAIRALGRIG-----------DPEAVPALLELLKD-EDPAVRRAAAEALGKIGDPEALPALLELLR 72
|
|
| HEAT |
pfam02985 |
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ... |
401-428 |
1.14e-03 |
|
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).
Pssm-ID: 460773 Cd Length: 31 Bit Score: 37.51 E-value: 1.14e-03
10 20
....*....|....*....|....*...
gi 17737759 401 VMSGVLNFLSDPHPRVRYAACNAIGQMS 428
Cdd:pfam02985 1 LLPLLLKLLNDPSPEVREAAAEALGELA 28
|
|
| Adaptin_N |
pfam01602 |
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ... |
127-553 |
1.54e-03 |
|
Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.
Pssm-ID: 396262 [Multi-domain] Cd Length: 523 Bit Score: 42.61 E-value: 1.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 127 PDILQFLFQCANSPTPQLQESA----LRIFSSVPSIFGNQeaqyIDLIKQMLaksmdagSDPEVRVQAvRAVGAF--ILY 200
Cdd:pfam01602 113 RDLAPDIKKLLVDRSPYVRKKAalaiLKLYRKSPDLVRDF----VPELKELL-------SDKDPGVQS-AAVALLyeICK 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 201 HDKENETAIHKHFADMLpRMIHITGE----------TIEAQDDQSLLKLLIEmtencpkFLRPQLE-----FIFEVCmKV 265
Cdd:pfam01602 181 NDRLYLKLLPLLFRRLC-NLLGVLNPwlqvkilrllTRLAPLDPLLPKELLE-------DLLNLLQnsnnaVLYETA-NT 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 266 FSSQDFEDSWRHLVLEVMVSLAENAPSMIRKRADKYIVALI----PLILHMMTDL-----DDDENWST-ADVVDDDDHSD 335
Cdd:pfam01602 252 IVHLAPAPELIVLAVNALGRLLSSPDENLRYVALRNLNKIVmkepKAVQHLDLIIfclktDDDISIRLrALDLLYALVNE 331
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 336 NNViaessldrlacglggKIVLPLVMNalpVMLGHADwkHRFAALMaISAIGEGCHK--QMEailDEVMSGVLNFLSDPH 413
Cdd:pfam01602 332 SNV---------------KEIVKELLK---YVHEIAD--PDFKIEL-VRAIGRLAEKfpTDA---EWYLDVLLDLLSLAG 387
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737759 414 PRVRYAACNAIGQMSTDFAQTFEKkfhsqVIPGLLSLLDDVENPRVQAHAGAALVNFSEdcpkniltRYLDGIMAK--LE 491
Cdd:pfam01602 388 SYVVDEIVEVIRDIIQNVPELREY-----ILEHLCELLEDIESPEALAAALWILGEYGE--------LIPNGSSPPdlLR 454
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17737759 492 TILNSKFKELVEkgnklVLEQVVTTIASVADTCESEFVayYDRL-MPCLKFIIQNANSDDLRM 553
Cdd:pfam01602 455 SILEVFVLESAK-----VRAAALTALAKLGLTSPEETT--QNLIiQLLLTLATQDSLDLEVRD 510
|
|
| Vac14_Fab1_bd |
pfam12755 |
Vacuolar 14 Fab1-binding region; Vac14 is a scaffold for the Fab1 kinase complex, a complex ... |
375-423 |
2.66e-03 |
|
Vacuolar 14 Fab1-binding region; Vac14 is a scaffold for the Fab1 kinase complex, a complex that allows for the dynamic interconversion of PI3P and PI(3,5)P2p (phosphoinositide phosphate (PIP) lipids, that are generated transiently on the cytoplasmic face of selected intracellular membranes). This interconversion is regulated by at least five proteins in yeast: the lipid kinase Fab1p, lipid phosphatase Fig4p, the Fab1p activator Vac7p, the Fab1p inhibitor Atg18p, and Vac14p, a protein required for the activity of both Fab1p and Fig4p. This domain appears to be the one responsible for binding to Fab1. The full length Vac14 in yeasts is likely to be a protein carrying a succession of HEAT repeats, most of which have now degenerated. This regulatory system is crucial for the proper functioning of the mammalian nervous system.
Pssm-ID: 403838 Cd Length: 97 Bit Score: 38.35 E-value: 2.66e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 17737759 375 HRFAALMAISAIGEGCHKQMEAILDEVMSGVLNFLSDPHPRVRYAACNA 423
Cdd:pfam12755 2 ARKGGLIGLAATAIALGKDIAPYLDDIIPPVLACFSDQDSRVRYYACES 50
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
353-427 |
3.73e-03 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 38.84 E-value: 3.73e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17737759 353 GKIVLPLVMNALPVMLGHADWKHRFAALMAISAIGEgchkqmeailDEVMSGVLNFLSDPHPRVRYAACNAIGQM 427
Cdd:COG1413 72 GRIGDPEAVPALIAALKDEDPEVRRAAAEALGRLGD----------PAAVPALLEALKDPDWEVRRAAARALGRL 136
|
|
| HEAT_EZ |
pfam13513 |
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ... |
414-470 |
4.00e-03 |
|
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.
Pssm-ID: 463906 [Multi-domain] Cd Length: 55 Bit Score: 36.58 E-value: 4.00e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 17737759 414 PRVRYAACNAIGQMSTDFAQTFeKKFHSQVIPGLLSLLDDvENPRVQAHAGAALVNF 470
Cdd:pfam13513 1 WRVREAAALALGSLAEGGPDLL-APAVPELLPALLPLLND-DSDLVREAAAWALGRL 55
|
|
| |
