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Conserved domains on  [gi|24644093|ref|NP_524228|]
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odd paired, isoform A [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf_ZIC pfam18366
Zic proteins zinc finger domain; This is the ZF1 (Zinc Finger 1) domain found in Zic family ...
 206-253 1.24e-19

Zic proteins zinc finger domain; This is the ZF1 (Zinc Finger 1) domain found in Zic family proteins found in Eukaryotes. In humans, there are five members of the Zic family that are involved in human congenital anomalies. One of them, ZIC3, causes X-linked heterotaxy (HTX1), which is a left-right axis disturbance that manifests as variable combinations of heart malformation, altered lung lobation, splenic abnormality and gastrointestinal malrotation. Zic faily proteins contain multiple zinc finger domains (ZFD), which are generally composed of five tandemly repeated C2H2 zinc finger (ZF) motifs. Sequence comparison analysis reveal that this N-terminal ZF (ZF1) domain of the Zic zinc finger domains is unique in that it possesses more amino acid residues (6-38 amino acids) between the two cysteine residues of the C2H2 motif compared to Gli and Glis ZF1s or any of the other ZFs (ZF2-5) in the Gli/Glis/Zic superfamily of proteins. Mutations in cysteine 253 (C253S) or histidine 286 (H286R) in ZIC3 ZF1, which are found in heterotaxy patients, result in extranuclear localization of the mutant ZIC3 protein. Furthermore, mutations in the evolutionarily conserved amino acid residues (C253, W255, C268, H281 and H286) of ZF1 generally impair nuclear localization.


:

Pssm-ID: 436441  Cd Length: 45  Bit Score: 82.44  E-value: 1.24e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 24644093   206 VKQEMQCLWIDPDQPGlvppgGRKTCNKVFHSMHEIVTHLTVEHVGGP 253
Cdd:pfam18366   3 IKQELSCKWIDPEQPA-----PKKPCNKTFSTMHEIVTHLTVEHVGGP 45
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 287-373 1.28e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 51.26  E-value: 1.28e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644093 287 GEKPFACPHPGCGKVFARSENLKIHKRthtgekpfkceHEGCDRRFANSSDRKKHSHVHTSDKPYNCRIngCDKSYTHPS 366
Cdd:COG5189 346 DGKPYKCPVEGCNKKYKNQNGLKYHML-----------HGHQNQKLHENPSPEKMNIFSAKDKPYRCEV--CDKRYKNLN 412


                ....*..
gi 24644093 367 SLRKHMK 373
Cdd:COG5189 413 GLKYHRK 419
 
Name Accession Description Interval E-value
zf_ZIC pfam18366
Zic proteins zinc finger domain; This is the ZF1 (Zinc Finger 1) domain found in Zic family ...
 206-253 1.24e-19

Zic proteins zinc finger domain; This is the ZF1 (Zinc Finger 1) domain found in Zic family proteins found in Eukaryotes. In humans, there are five members of the Zic family that are involved in human congenital anomalies. One of them, ZIC3, causes X-linked heterotaxy (HTX1), which is a left-right axis disturbance that manifests as variable combinations of heart malformation, altered lung lobation, splenic abnormality and gastrointestinal malrotation. Zic faily proteins contain multiple zinc finger domains (ZFD), which are generally composed of five tandemly repeated C2H2 zinc finger (ZF) motifs. Sequence comparison analysis reveal that this N-terminal ZF (ZF1) domain of the Zic zinc finger domains is unique in that it possesses more amino acid residues (6-38 amino acids) between the two cysteine residues of the C2H2 motif compared to Gli and Glis ZF1s or any of the other ZFs (ZF2-5) in the Gli/Glis/Zic superfamily of proteins. Mutations in cysteine 253 (C253S) or histidine 286 (H286R) in ZIC3 ZF1, which are found in heterotaxy patients, result in extranuclear localization of the mutant ZIC3 protein. Furthermore, mutations in the evolutionarily conserved amino acid residues (C253, W255, C268, H281 and H286) of ZF1 generally impair nuclear localization.


Pssm-ID: 436441  Cd Length: 45  Bit Score: 82.44  E-value: 1.24e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 24644093   206 VKQEMQCLWIDPDQPGlvppgGRKTCNKVFHSMHEIVTHLTVEHVGGP 253
Cdd:pfam18366   3 IKQELSCKWIDPEQPA-----PKKPCNKTFSTMHEIVTHLTVEHVGGP 45
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 287-373 1.28e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 51.26  E-value: 1.28e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644093 287 GEKPFACPHPGCGKVFARSENLKIHKRthtgekpfkceHEGCDRRFANSSDRKKHSHVHTSDKPYNCRIngCDKSYTHPS 366
Cdd:COG5189 346 DGKPYKCPVEGCNKKYKNQNGLKYHML-----------HGHQNQKLHENPSPEKMNIFSAKDKPYRCEV--CDKRYKNLN 412


                ....*..
gi 24644093 367 SLRKHMK 373
Cdd:COG5189 413 GLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
307-334 7.33e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.33e-04
                          10        20
                  ....*....|....*....|....*...
gi 24644093   307 NLKIHKRTHTGEKPFKCEHegCDRRFAN 334
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
 
Name Accession Description Interval E-value
zf_ZIC pfam18366
Zic proteins zinc finger domain; This is the ZF1 (Zinc Finger 1) domain found in Zic family ...
 206-253 1.24e-19

Zic proteins zinc finger domain; This is the ZF1 (Zinc Finger 1) domain found in Zic family proteins found in Eukaryotes. In humans, there are five members of the Zic family that are involved in human congenital anomalies. One of them, ZIC3, causes X-linked heterotaxy (HTX1), which is a left-right axis disturbance that manifests as variable combinations of heart malformation, altered lung lobation, splenic abnormality and gastrointestinal malrotation. Zic faily proteins contain multiple zinc finger domains (ZFD), which are generally composed of five tandemly repeated C2H2 zinc finger (ZF) motifs. Sequence comparison analysis reveal that this N-terminal ZF (ZF1) domain of the Zic zinc finger domains is unique in that it possesses more amino acid residues (6-38 amino acids) between the two cysteine residues of the C2H2 motif compared to Gli and Glis ZF1s or any of the other ZFs (ZF2-5) in the Gli/Glis/Zic superfamily of proteins. Mutations in cysteine 253 (C253S) or histidine 286 (H286R) in ZIC3 ZF1, which are found in heterotaxy patients, result in extranuclear localization of the mutant ZIC3 protein. Furthermore, mutations in the evolutionarily conserved amino acid residues (C253, W255, C268, H281 and H286) of ZF1 generally impair nuclear localization.


Pssm-ID: 436441  Cd Length: 45  Bit Score: 82.44  E-value: 1.24e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 24644093   206 VKQEMQCLWIDPDQPGlvppgGRKTCNKVFHSMHEIVTHLTVEHVGGP 253
Cdd:pfam18366   3 IKQELSCKWIDPEQPA-----PKKPCNKTFSTMHEIVTHLTVEHVGGP 45
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 287-373 1.28e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 51.26  E-value: 1.28e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644093 287 GEKPFACPHPGCGKVFARSENLKIHKRthtgekpfkceHEGCDRRFANSSDRKKHSHVHTSDKPYNCRIngCDKSYTHPS 366
Cdd:COG5189 346 DGKPYKCPVEGCNKKYKNQNGLKYHML-----------HGHQNQKLHENPSPEKMNIFSAKDKPYRCEV--CDKRYKNLN 412


                ....*..
gi 24644093 367 SLRKHMK 373
Cdd:COG5189 413 GLKYHRK 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
265-384 4.99e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 4.99e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644093 265 CSRNGRPFKAKYKLVNHIRVHTGEKPFACPHPGCGKVFARSENLKIHKRTHTGEKPFKCEHEGCDRRFANSSDrKKHSHV 344
Cdd:COG5048  36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSS-SLSSSS 114

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 24644093 345 HTSDKPYNCRINGCDKSYTHPS--SLRKHMKVHGNVDEKSPS 384
Cdd:COG5048 115 SNSNDNNLLSSHSLPPSSRDPQlpDLLSISNLRNNPLPGNNS 156
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
265-375 1.11e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 1.11e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644093 265 CSRNGRPFKAKYKLVNHIR--VHTGE--KPFACPHPGCGKVFARSENLKIHKRTHTGEKPFK------------------ 322
Cdd:COG5048 292 SKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKekllnssskfspllnnep 371

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644093 323 -----------------CEHEGCDRRFANSSDRKKHSHVHTSDKPYNCRINGCDKSYTHPSSLRKHMKVH 375
Cdd:COG5048 372 pqslqqykdlkndkkseTLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
307-334 7.33e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.33e-04
                          10        20
                  ....*....|....*....|....*...
gi 24644093   307 NLKIHKRTHTGEKPFKCEHegCDRRFAN 334
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
293-385 1.46e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.46e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644093 293 CPHPGCGKVFARSENLKIHKRT--HTGE--KPFKCEHEGCDRRFANSSDRKKHSHVHTSDKPYNCRINGCDKSYTHPSsl 368
Cdd:COG5048 290 IKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL-- 367

                        90
                ....*....|....*..
gi 24644093 369 rkHMKVHGNVDEKSPSH 385
Cdd:COG5048 368 --NNEPPQSLQQYKDLK 382
zf-H2C2_2 pfam13465
Zinc-finger double domain;
278-304 8.71e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.71e-03
                          10        20
                  ....*....|....*....|....*..
gi 24644093   278 LVNHIRVHTGEKPFACPHpgCGKVFAR 304
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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