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Conserved domains on  [gi|28571814|ref|NP_524448|]
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pyruvate kinase, isoform A [Drosophila melanogaster]

Protein Classification

pyruvate kinase( domain architecture ID 10084586)

pyruvate kinase catalyzes the phosphorylation of pyruvate to form phosphoenolpyruvate and functions in regulating glycolysis

CATH:  2.40.33.10|3.20.20.60|3.40.1380.20
EC:  2.7.1.40
Gene Ontology:  GO:0004743|GO:0006096|GO:0005524|GO:0030955|GO:0000287
PubMed:  31342570
SCOP:  4003255|4002474|4000500

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 46-532 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


:

Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 726.80  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  46 RLSGIVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAVKNYSaklgyeHPVAIALDTKGPEIRTG 125
Cdd:cd00288   2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRTG 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814 126 LIGGSgtAEIELKKGEKIKLTTNKEfLEKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDS-LTCEVENGG 204
Cdd:cd00288  76 LFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGG 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814 205 SLGSRKGVNLPGVPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEKGKNIKIISKIENQQGMHNLD 284
Cdd:cd00288 153 VLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFD 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814 285 EIIEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGADCVML 364
Cdd:cd00288 233 EILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVML 312

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814 365 SGETAKGEYPLECVLTMAKTCKEAEAALWHQNLFNDLVRGAGT-IDASHAAAIAAVEAATKAKASAIVVITTSGKSAFQV 443
Cdd:cd00288 313 SGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRpTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLV 392

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814 444 SKYRPRCPIIAVTRFAQTARQAHLYRGLVPLIYKEPGLGdWLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTGWKQGSGF 523
Cdd:cd00288 393 SKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKPG-WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGS 471


                ....*....
gi 28571814 524 TNTIRIVTV 532
Cdd:cd00288 472 TNTMRILTV 480
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 46-532 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 726.80  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  46 RLSGIVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAVKNYSaklgyeHPVAIALDTKGPEIRTG 125
Cdd:cd00288   2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRTG 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814 126 LIGGSgtAEIELKKGEKIKLTTNKEfLEKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDS-LTCEVENGG 204
Cdd:cd00288  76 LFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGG 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814 205 SLGSRKGVNLPGVPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEKGKNIKIISKIENQQGMHNLD 284
Cdd:cd00288 153 VLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFD 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814 285 EIIEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGADCVML 364
Cdd:cd00288 233 EILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVML 312

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814 365 SGETAKGEYPLECVLTMAKTCKEAEAALWHQNLFNDLVRGAGT-IDASHAAAIAAVEAATKAKASAIVVITTSGKSAFQV 443
Cdd:cd00288 313 SGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRpTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLV 392

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814 444 SKYRPRCPIIAVTRFAQTARQAHLYRGLVPLIYKEPGLGdWLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTGWKQGSGF 523
Cdd:cd00288 393 SKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKPG-WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGS 471


                ....*....
gi 28571814 524 TNTIRIVTV 532
Cdd:cd00288 472 TNTMRILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 46-529 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 649.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814    46 RLSGIVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAvknySAKLGyeHPVAIALDTKGPEIRTG 125
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREA----AEKLG--RPVAILLDTKGPEIRTG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   126 LIGGSgtaEIELKKGEKIKLTTNKEFLEkGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDSLTCEVENGGS 205
Cdd:TIGR01064  75 EIKGG---EVKLKKGDKVIITTDDIKGE-GDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   206 LGSRKGVNLPGVPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEKG-KNIKIISKIENQQGMHNLD 284
Cdd:TIGR01064 151 LKSKKGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNID 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   285 EIIEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGADCVML 364
Cdd:TIGR01064 231 EIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVML 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   365 SGETAKGEYPLECVLTMAKTCKEAEAALWHQNLFNDLVRGA---GTIDASHAAAIAAVEAatKAKASAIVVITTSGKSAF 441
Cdd:TIGR01064 311 SGETAKGKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDpkpSTITEAIALSAVEAAE--KLDAKAIVVLTESGRTAR 388

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   442 QVSKYRPRCPIIAVTRFAQTARQAHLYRGLVPLIYkepglGDWLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTG-WKQG 520
Cdd:TIGR01064 389 LLSKYRPNAPIIAVTPNERVARQLALYWGVFPFLV-----DEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGG 463


                  ....*....
gi 28571814   521 SGFTNTIRI 529
Cdd:TIGR01064 464 EGGTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 50-532 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 644.78  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  50 IVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAvknySAKLGyeHPVAIALDTKGPEIRTGLIGG 129
Cdd:COG0469   7 IVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREA----AKELG--RPVAILLDLQGPKIRTGKFKE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814 130 SGtaeIELKKGEKIKLTTNKEfleKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDSLTCEVENGGSLGSR 209
Cdd:COG0469  81 GP---VELKKGDTFTLTTDDV---EGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSR 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814 210 KGVNLPGVPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEKGKNIKIISKIENQQGMHNLDEIIEA 289
Cdd:COG0469 155 KGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEA 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814 290 GDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGADCVMLSGETA 369
Cdd:COG0469 235 SDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETA 314

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814 370 KGEYPLECVLTMAKTCKEAEAALWHQNLFNDLVRGAGTidashaaaiaaveAATKA------------KASAIVVITTSG 437
Cdd:COG0469 315 VGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPER-------------TITDAiaraavelaedlGAKAIVAFTESG 381

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814 438 KSAFQVSKYRPRCPIIAVTRFAQTARQAHLYRGLVPLIYKEPglgdwlKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTGW 517
Cdd:COG0469 382 STARRISRYRPKVPILALTPNERTARRLALVWGVYPVLVDDV------ESTDEMIEEAVEALLEEGLVKPGDLVVITAGV 455

                       490
                ....*....|....*.
gi 28571814 518 KQG-SGFTNTIRIVTV 532
Cdd:COG0469 456 PVGvPGTTNTLKVHRV 471
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 46-398 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 564.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814    46 RLSGIVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAVKNYSaklgyeHPVAIALDTKGPEIRTG 125
Cdd:pfam00224   2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTG------GTVAIALDTKGPEIRTG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   126 LIGGsGTAEIELKKGEKIKLTTNKEFLEKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDS-LTCEVENGG 204
Cdd:pfam00224  76 NTKD-GKKDIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNGG 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   205 SLGSRKGVNLPGVPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEKGKNIKIISKIENQQGMHNLD 284
Cdd:pfam00224 155 VIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFD 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   285 EIIEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGADCVML 364
Cdd:pfam00224 235 EILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVML 314

                         330       340       350
                  ....*....|....*....|....*....|....
gi 28571814   365 SGETAKGEYPLECVLTMAKTCKEAEAALWHQNLF 398
Cdd:pfam00224 315 SGETAKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK05826 PRK05826
pyruvate kinase; Provisional
 50-516 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 547.44  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   50 IVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAvknySAKLGyeHPVAIALDTKGPEIRTGLIGG 129
Cdd:PRK05826   8 IVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREI----AAKLG--RPVAILLDLKGPKIRVGKFKE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  130 SgtaEIELKKGEKIKLTTNKEflEKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDSLTCEVENGGSLGSR 209
Cdd:PRK05826  82 G---KITLKTGDKFTLDTDQK--EEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNN 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  210 KGVNLPGVPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEKG-KNIKIISKIENQQGMHNLDEIIE 288
Cdd:PRK05826 157 KGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGcPHAKIIAKIERAEAVDNIDEIIE 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  289 AGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGADCVMLSGET 368
Cdd:PRK05826 237 ASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGET 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  369 AKGEYPLECVLTMAKTCKEAEAALWHQNLFNDLVRGAGTIDASHAAAIAAVEAATKaKASAIVVITTSGKSAFQVSKYRP 448
Cdd:PRK05826 317 AAGKYPVEAVEAMARICKGAEKEFSINLSKHRLDRQFDRIDEAIAMSAMYAANHLK-GVKAIVALTESGRTARLISRFRP 395

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28571814  449 RCPIIAVTRFAQTARQAHLYRGLVPLIYKEPGLGD-WLKDVdvrvqfgLQVGKKNGFIKTGDSVVVVTG 516
Cdd:PRK05826 396 GAPIFAVTRDEKTQRRLALYRGVYPVLFDSAADTDdAAEEA-------LRLLLEKGLVESGDLVVVTSG 457
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 46-532 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 726.80  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  46 RLSGIVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAVKNYSaklgyeHPVAIALDTKGPEIRTG 125
Cdd:cd00288   2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRTG 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814 126 LIGGSgtAEIELKKGEKIKLTTNKEfLEKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDS-LTCEVENGG 204
Cdd:cd00288  76 LFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGG 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814 205 SLGSRKGVNLPGVPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEKGKNIKIISKIENQQGMHNLD 284
Cdd:cd00288 153 VLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFD 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814 285 EIIEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGADCVML 364
Cdd:cd00288 233 EILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVML 312

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814 365 SGETAKGEYPLECVLTMAKTCKEAEAALWHQNLFNDLVRGAGT-IDASHAAAIAAVEAATKAKASAIVVITTSGKSAFQV 443
Cdd:cd00288 313 SGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRpTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLV 392

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814 444 SKYRPRCPIIAVTRFAQTARQAHLYRGLVPLIYKEPGLGdWLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTGWKQGSGF 523
Cdd:cd00288 393 SKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKPG-WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGS 471


                ....*....
gi 28571814 524 TNTIRIVTV 532
Cdd:cd00288 472 TNTMRILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 46-529 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 649.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814    46 RLSGIVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAvknySAKLGyeHPVAIALDTKGPEIRTG 125
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREA----AEKLG--RPVAILLDTKGPEIRTG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   126 LIGGSgtaEIELKKGEKIKLTTNKEFLEkGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDSLTCEVENGGS 205
Cdd:TIGR01064  75 EIKGG---EVKLKKGDKVIITTDDIKGE-GDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   206 LGSRKGVNLPGVPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEKG-KNIKIISKIENQQGMHNLD 284
Cdd:TIGR01064 151 LKSKKGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNID 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   285 EIIEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGADCVML 364
Cdd:TIGR01064 231 EIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVML 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   365 SGETAKGEYPLECVLTMAKTCKEAEAALWHQNLFNDLVRGA---GTIDASHAAAIAAVEAatKAKASAIVVITTSGKSAF 441
Cdd:TIGR01064 311 SGETAKGKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDpkpSTITEAIALSAVEAAE--KLDAKAIVVLTESGRTAR 388

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   442 QVSKYRPRCPIIAVTRFAQTARQAHLYRGLVPLIYkepglGDWLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTG-WKQG 520
Cdd:TIGR01064 389 LLSKYRPNAPIIAVTPNERVARQLALYWGVFPFLV-----DEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGG 463


                  ....*....
gi 28571814   521 SGFTNTIRI 529
Cdd:TIGR01064 464 EGGTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 50-532 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 644.78  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  50 IVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAvknySAKLGyeHPVAIALDTKGPEIRTGLIGG 129
Cdd:COG0469   7 IVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREA----AKELG--RPVAILLDLQGPKIRTGKFKE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814 130 SGtaeIELKKGEKIKLTTNKEfleKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDSLTCEVENGGSLGSR 209
Cdd:COG0469  81 GP---VELKKGDTFTLTTDDV---EGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSR 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814 210 KGVNLPGVPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEKGKNIKIISKIENQQGMHNLDEIIEA 289
Cdd:COG0469 155 KGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEA 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814 290 GDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGADCVMLSGETA 369
Cdd:COG0469 235 SDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETA 314

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814 370 KGEYPLECVLTMAKTCKEAEAALWHQNLFNDLVRGAGTidashaaaiaaveAATKA------------KASAIVVITTSG 437
Cdd:COG0469 315 VGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPER-------------TITDAiaraavelaedlGAKAIVAFTESG 381

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814 438 KSAFQVSKYRPRCPIIAVTRFAQTARQAHLYRGLVPLIYKEPglgdwlKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTGW 517
Cdd:COG0469 382 STARRISRYRPKVPILALTPNERTARRLALVWGVYPVLVDDV------ESTDEMIEEAVEALLEEGLVKPGDLVVITAGV 455

                       490
                ....*....|....*.
gi 28571814 518 KQG-SGFTNTIRIVTV 532
Cdd:COG0469 456 PVGvPGTTNTLKVHRV 471
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 46-398 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 564.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814    46 RLSGIVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAVKNYSaklgyeHPVAIALDTKGPEIRTG 125
Cdd:pfam00224   2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTG------GTVAIALDTKGPEIRTG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   126 LIGGsGTAEIELKKGEKIKLTTNKEFLEKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDS-LTCEVENGG 204
Cdd:pfam00224  76 NTKD-GKKDIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNGG 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   205 SLGSRKGVNLPGVPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEKGKNIKIISKIENQQGMHNLD 284
Cdd:pfam00224 155 VIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFD 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   285 EIIEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGADCVML 364
Cdd:pfam00224 235 EILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVML 314

                         330       340       350
                  ....*....|....*....|....*....|....
gi 28571814   365 SGETAKGEYPLECVLTMAKTCKEAEAALWHQNLF 398
Cdd:pfam00224 315 SGETAKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK05826 PRK05826
pyruvate kinase; Provisional
 50-516 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 547.44  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   50 IVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAvknySAKLGyeHPVAIALDTKGPEIRTGLIGG 129
Cdd:PRK05826   8 IVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREI----AAKLG--RPVAILLDLKGPKIRVGKFKE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  130 SgtaEIELKKGEKIKLTTNKEflEKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDSLTCEVENGGSLGSR 209
Cdd:PRK05826  82 G---KITLKTGDKFTLDTDQK--EEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNN 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  210 KGVNLPGVPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEKG-KNIKIISKIENQQGMHNLDEIIE 288
Cdd:PRK05826 157 KGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGcPHAKIIAKIERAEAVDNIDEIIE 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  289 AGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGADCVMLSGET 368
Cdd:PRK05826 237 ASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGET 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  369 AKGEYPLECVLTMAKTCKEAEAALWHQNLFNDLVRGAGTIDASHAAAIAAVEAATKaKASAIVVITTSGKSAFQVSKYRP 448
Cdd:PRK05826 317 AAGKYPVEAVEAMARICKGAEKEFSINLSKHRLDRQFDRIDEAIAMSAMYAANHLK-GVKAIVALTESGRTARLISRFRP 395

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28571814  449 RCPIIAVTRFAQTARQAHLYRGLVPLIYKEPGLGD-WLKDVdvrvqfgLQVGKKNGFIKTGDSVVVVTG 516
Cdd:PRK05826 396 GAPIFAVTRDEKTQRRLALYRGVYPVLFDSAADTDdAAEEA-------LRLLLEKGLVESGDLVVVTSG 457
PLN02461 PLN02461
Probable pyruvate kinase
 50-533 0e+00

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 522.23  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   50 IVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAVKNySAKLgyehpVAIALDTKGPEIRTGLIGG 129
Cdd:PLN02461  25 IVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMAN-TGIL-----CAVMLDTKGPEIRTGFLKD 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  130 SGTaeIELKKGEKIKLTTNKEFleKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVRE--VGKDSLTCEVENGGSLG 207
Cdd:PLN02461  99 GKP--VQLKQGQEITITTDYSI--KGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLScdVEAGTVRCRCENSAMLG 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  208 SRKGVNLPGVPVDLPAVSEKDKSDLL-FGVEQEVDMIFASFIRNAAALTEIRKVLGEKGKNIKIISKIENQQGMHNLDEI 286
Cdd:PLN02461 175 ERKNVNLPGVVVDLPTLTEKDKEDILqWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLDNFDDI 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  287 IEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGADCVMLSG 366
Cdd:PLN02461 255 LAESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSG 334

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  367 ETAKGEYPLECVLTMAKTCKEAEAALWHQNLFNDLVRGAGT-IDASHAAAIAAVEAATKAKASAIVVITTSGKSAFQVSK 445
Cdd:PLN02461 335 ETAAGAYPELAVKTMARICREAEASLDYGALFKEIMRSAPLpMSPLESLASSAVRTANKVKASLIVVLTRGGTTARLVAK 414

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  446 YRPRCPIIAVT-------RFAQT------ARQAHLYRGLVPLIYKEPGLGDWLKDVDVRVQFGLQVGKKNGFIKTGDSVV 512
Cdd:PLN02461 415 YRPAVPILSVVvpeittdSFDWScsdeapARHSLIYRGLIPVLAEGSAKATDSESTEEILEAAIEHAKKKGLCKPGDSVV 494

                        490       500
                 ....*....|....*....|.
gi 28571814  513 VVtgwkQGSGFTNTIRIVTVE 533
Cdd:PLN02461 495 AL----HRIGGASVIKILTVK 511
PRK09206 PRK09206
pyruvate kinase PykF;
50-529 7.40e-179

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 511.52  E-value: 7.40e-179
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   50 IVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAVKNYSAKlgyehpVAIALDTKGPEIRTG-LIG 128
Cdd:PRK09206   6 IVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKK------AAILLDTKGPEIRTMkLEG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  129 GsgtAEIELKKGEKIKLTTNKEFLekGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDSLTCEVENGGSLGS 208
Cdd:PRK09206  80 G---NDVSLKAGQTFTFTTDKSVV--GNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGE 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  209 RKGVNLPGVPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGE-KGKNIKIISKIENQQGMHNLDEII 287
Cdd:PRK09206 155 NKGVNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAhGGENIQIISKIENQEGLNNFDEIL 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  288 EAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGADCVMLSGE 367
Cdd:PRK09206 235 EASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGE 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  368 TAKGEYPLECVLTMAKTCKEAEAA----LWHQNLFNDL------VRGAgtidashaaaiaaVEAATKAKASAIVVITTSG 437
Cdd:PRK09206 315 SAKGKYPLEAVSIMATICERTDRVmnsrLESNNDNRKLriteavCRGA-------------VETAEKLDAPLIVVATQGG 381

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  438 KSAFQVSKYRPRCPIIAVTRFAQTARQAHLYRGLVPLIYKEpglgdwLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTGW 517
Cdd:PRK09206 382 KSARSVRKYFPDATILALTTNEKTARQLVLSKGVVPQLVKE------IASTDDFYRLGKELALQSGLAQKGDVVVMVSGA 455

                        490
                 ....*....|..
gi 28571814  518 KQGSGFTNTIRI 529
Cdd:PRK09206 456 LVPSGTTNTASV 467
PTZ00300 PTZ00300
pyruvate kinase; Provisional
 72-533 5.15e-175

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 501.12  E-value: 5.15e-175
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   72 MNIARMNFSHGSHEYHAATVANVRQAvknySAKLGYEhpVAIALDTKGPEIRTGLIGGSGTAeieLKKGEKIKLTTNKEF 151
Cdd:PTZ00300   1 MSVARMNFSHGSHEYHQTTINNVRQA----AAELGVN--IAIALDTKGPEIRTGLFVGGEAV---MERGATCYVTTDPAF 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  152 LEKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVR-EVGKDSLTCEVENGGSLGSRKGVNLPGVPVDLPAVSEKDKS 230
Cdd:PTZ00300  72 ADKGTKDKFYIDYQNLSKVVRPGGYIYIDDGILILHVQsHEDEQTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  231 DLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEKGKNIKIISKIENQQGMHNLDEIIEAGDGIMVARGDLGIEIPAEKVF 310
Cdd:PTZ00300 152 DLQFGVEQGVDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVV 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  311 LAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGADCVMLSGETAKGEYPLECVLTMAKTCKEAEA 390
Cdd:PTZ00300 232 VAQKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQS 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  391 ALWHQNLFNDLVRGAGT-IDASHAAAIAAVEAATKAKASAIVVITTSGKSAFQVSKYRPRCPIIAVTRFAQTARQAHLYR 469
Cdd:PTZ00300 312 AVNEYVFFNSIKKLQPIpMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQ 391

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28571814  470 GLVPLIYKEPGLGDwLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTGWKQGSGFTNTIRIVTVE 533
Cdd:PTZ00300 392 GVESVFFDAERLGH-DEGKEQRVAMGVGFAKSKGYVQSGDLMVVVHADHKVKGYANQTRIILVS 454
PRK06354 PRK06354
pyruvate kinase; Provisional
 40-532 1.87e-169

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 492.13  E-value: 1.87e-169
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   40 SPVPHVRLSGIVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAVKnysaKLGyeHPVAIALDTKG 119
Cdd:PRK06354   2 SLRDLMRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASK----KLG--KTVGILQDLQG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  120 PEIRTG-LIGGSgtaeIELKKGEKIKLTtNKEFLekGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDS--L 196
Cdd:PRK06354  76 PKIRLGrFEDGP----IELKTGDEFILT-SREVL--GTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADgeL 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  197 TCEVENGGSLGSRKGVNLPGVPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEK-GKNIKIISKIE 275
Cdd:PRK06354 149 HCKVLVGGVLSNKKGVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHnGKHIPIIAKIE 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  276 NQQGMHNLDEIIEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAV 355
Cdd:PRK06354 229 KQEAIDNIDAILELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAI 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  356 LDGADCVMLSGETAKGEYPLECVLTMAKTCKEAEAALWHQNLFNDLVRGAGTIdaSHAAAIAAVEAATKAKASAIVVITT 435
Cdd:PRK06354 309 LDGTDAVMLSNETAAGDYPVEAVQTMATIAVRIEKDLPYRDILSKRPEFTTTI--TNAISQAVSHIALQLDAAAIVTLTK 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  436 SGKSAFQVSKYRPRCPIIAVTRFAQTARQAHLYRGLVPLiykepgLGDWLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVT 515
Cdd:PRK06354 387 SGATARNVSKYRPKTPILAVTPNESVARRLQLVWGVTPL------LVLDAPSTDETFDAAINVAQESGLLKQGDLVVITA 460

                        490
                 ....*....|....*...
gi 28571814  516 GWKQG-SGFTNTIRIVTV 532
Cdd:PRK06354 461 GTLVGeSGSTDLMKVHVV 478
PTZ00066 PTZ00066
pyruvate kinase; Provisional
 50-533 1.04e-164

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 477.33  E-value: 1.04e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   50 IVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAvknysAKLGYEHPVAIALDTKGPEIRTGLIgg 129
Cdd:PTZ00066  42 IVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREA-----AKARPNANLGILLDTKGPEIRTGFL-- 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  130 SGTAEIELKKGEKIKLTTNKEFLekGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDSLTCEVENGGSLGSR 209
Cdd:PTZ00066 115 KNHKPITLKEGQTLKITTDYTFL--GDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGER 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  210 KGVNLPGVPVDLPAVSEKDKSDLL-FGVEQEVDMIFASFIRNAAALTEIRKVLGEKGKNIKIISKIENQQGMHNLDEIIE 288
Cdd:PTZ00066 193 KNMNLPGVKVELPVIGEKDKNDILnFAIPMGCDFIALSFVQSADDVRLCRQLLGERGRHIKIIPKIENIEGLINFDEILA 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  289 AGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGADCVMLSGET 368
Cdd:PTZ00066 273 ESDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGET 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  369 AKGEYPLECVLTMAKTCKEAEAALWHQNLFNDLVRGAGT-IDASHAAAIAAVEAATKAKASAIVVITTSGKSAFQVSKYR 447
Cdd:PTZ00066 353 ANGKFPVEAVNIMAKICFEAETCIDYRVLYHAIHLAVPTpVSVQEAVARSAVETAEDINAKLIIALTETGNTARLISKYR 432

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  448 PRCPIIAVTRFAQTARQAHLYRGLVPLiykepgLGDWLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTGWKQG-SGFTNT 526
Cdd:PTZ00066 433 PSCTILALSASPSVVKSLSVARGVTTY------VVNSFQGTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEvAGSSNL 506


                 ....*..
gi 28571814  527 IRIVTVE 533
Cdd:PTZ00066 507 MKVVKIP 513
PRK06247 PRK06247
pyruvate kinase; Provisional
 50-532 4.24e-144

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 423.18  E-value: 4.24e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   50 IVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAvknySAKLGYehPVAIALDTKGPEIRtglIGG 129
Cdd:PRK06247   9 ILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREV----EDETGR--PIGILADLQGPKLR---LGR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  130 SGTAEIELKKGEKIKLTTNKEfleKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDSLTCEVENGGSLGSR 209
Cdd:PRK06247  80 FADGKVQLANGQTFRLDVDDA---PGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  210 KGVNLPGVPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEKgknIKIISKIENQQGMHNLDEIIEA 289
Cdd:PRK06247 157 KGVSLPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGGR---VPVMAKIEKPQAIDRLEAIVEA 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  290 GDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGADCVMLSGETA 369
Cdd:PRK06247 234 SDAIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETA 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  370 KGEYPLECVLTMAKTCKEAEA-----ALWHQNLFNDLVRGAGTIDASHAAAIAAVeaatkaKASAIVVITTSGKSAFQVS 444
Cdd:PRK06247 314 SGKYPVEAVRTMARIIRQVERdptypPLIHAQRPQPEATKRDAISYAARDIAERL------DLAALVAYTSSGDTALRAA 387

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  445 KYRPRCPIIAVTRFAQTARQAHLYRGLvpliykEPGLGDWLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTGWKQG-SGF 523
Cdd:PRK06247 388 RERPPLPILALTPNPETARRLALTWGV------HCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGtPGS 461


                 ....*....
gi 28571814  524 TNTIRIVTV 532
Cdd:PRK06247 462 TNMLRIAYI 470
PLN02765 PLN02765
pyruvate kinase
 39-533 4.28e-122

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 368.61  E-value: 4.28e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   39 DSPVPhvRLSGIVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAVKNySAKLgyehpVAIALDTK 118
Cdd:PLN02765  23 PSFFP--ALTKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKN-TKKL-----CAVMLDTV 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  119 GPEIRtglIGGSGTAEIELKKGEKIKLTTNKEflEKGSLEIVYVDYENIVNVVKPGNRVFVDDGLIS--------LIVRE 190
Cdd:PLN02765  95 GPELQ---VINKTEKPISLKAGNTVTLTPDQS--KEASSEVLPINFPGLAKAVKPGDTIFVGQYLFTgsettsvwLEVDE 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  191 VGKDSLTCEVENGGSL-GSRKGVNLPGVPVDLPAVSEKDKSDL-LFGVEQEVDMIFASFIRNAAALTEIRKVLGEKG-KN 267
Cdd:PLN02765 170 VKGDDVVCTVKNSATLaGSLFTLHVSQVRIDLPTLSEKDKEVIsTWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGlSQ 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  268 IKIISKIENQQGMHNLDEIIEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVIcATQMLESMVKKPRPTRAE 347
Cdd:PLN02765 250 TQIFAKIENVEGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAV-VTRVVDSMTDNLRPTRAE 328

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  348 ISDVANAVLDGADCVMLSGETAKGEYPLECVLTMAKTCKEAEAALWHQNLFNDLVRGAGT-IDASHAAAIAAVEAATKAK 426
Cdd:PLN02765 329 ATDVANAVLDGADAILLGAETLRGLYPVETISTVGRICAEAEKVFNQDLYFKKTVKYVGEpMSHLESIASSAVRAAIKVK 408

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  427 ASAIVVITTSGKSAFQVSKYRPRCPIIAVT-----------RF--AQTARQAHLYRGLVPLIY--KEPGLGDWLKDVDVr 491
Cdd:PLN02765 409 ASVIIVFTSSGRAARLIAKYRPTMPVLSVViprlktnqlkwSFtgAFQARQCLIVRGLFPMLAdpRHSAESTSATNESV- 487

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|..
gi 28571814  492 VQFGLQVGKKNGFIKTGDSVVVVtgwkQGSGFTNTIRIVTVE 533
Cdd:PLN02765 488 LKVALDHGKAAGVIKSHDRVVVC----QKVGDSSVVKIIELD 525
PLN02623 PLN02623
pyruvate kinase
 2-519 1.23e-112

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 346.15  E-value: 1.23e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814    2 VNVTIYDEAPQ-LKPNEVPQNMAAGADTQLEHMCRLQFDSPVPHVRLSGIVCTIGPASSSVEMLEKMMATGMNIARMNFS 80
Cdd:PLN02623  65 QETEVIPVSPEdGGANFVEDNEEVLLEIQQLGETAVGMWSKPSVRRKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMS 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   81 HGSHEYHAATVanvrQAVKNYSAKlGYEHPVAIALDTKGPEIRTGLIggsgTAEIELKKGEKIKLTTNKEFlekGSLEIV 160
Cdd:PLN02623 145 HGDHASHQKVI----DLVKEYNAQ-SKDNVIAIMLDTKGPEVRSGDL----PQPIMLEEGQEFTFTIKRGV---STEDCV 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  161 YVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDSLTCEVENGGSLGSRKGVNLPGVPVDLPAVSEKDKSDLLFGVEQEV 240
Cdd:PLN02623 213 SVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKCEVVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVENKV 292

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  241 DMIFASFIRNAAALTEIRKVLGEKGKNIKIISKIENQQGMHNLDEIIEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARC 320
Cdd:PLN02623 293 DFYAVSFVKDAQVVHELKDYLKSCNADIHVIVKIESADSIPNLHSIITASDGAMVARGDLGAELPIEEVPLLQEEIIRRC 372

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  321 NKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGADCVMLSGETAKGEYPLECVLTMAKTCKEAEAALWHQNLFND 400
Cdd:PLN02623 373 RSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKFPLKAVKVMHTVALRTEATLPEGTTPPN 452

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  401 LVRGAGTIDASHAAAIAAVEAATkaKASAIVVITTSGKSAFQVSKYRPRCPIIAVTRFAQTARQAHLYRGLVPlIYKEpg 480
Cdd:PLN02623 453 LGQAFKNHMSEMFAFHATMMANT--LGTSIIVFTRTGFMAILLSHYRPSGTIFAFTNEKRIQQRLALYQGVCP-IYMQ-- 527

                        490       500       510
                 ....*....|....*....|....*....|....*....
gi 28571814  481 lgdWLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTGWKQ 519
Cdd:PLN02623 528 ---FSDDAEETFARALSLLLNKGMVKEGEEVALVQSGRQ 563
PRK06739 PRK06739
pyruvate kinase; Validated
 51-389 7.99e-101

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 308.03  E-value: 7.99e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   51 VCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQavknysaklgYEHPVAIALDTKGPEIRTGLIGGS 130
Cdd:PRK06739   6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKS----------LDDSIKILGDVQGPKIRLGEIKGE 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  131 gtaEIELKKGEKIKLTTNKEfleKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDSLTCEVENGGSLGSRK 210
Cdd:PRK06739  76 ---QITLQAGDSFILHTQPV---TGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHK 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  211 GVNLPGVPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEKGKNI-KIISKIENQQGMHNLDEIIEA 289
Cdd:PRK06739 150 GVNLPGAIVRLPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSpNLIAKIETMEAIENFQDICKE 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  290 GDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGADCVMLSGETA 369
Cdd:PRK06739 230 ADGIMIARGDLGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESA 309

                        330       340
                 ....*....|....*....|
gi 28571814  370 KGEYPLECVLTMAKTCKEAE 389
Cdd:PRK06739 310 SGEHPIESVSTLRLVSEFAE 329
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
 45-533 3.67e-92

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 290.88  E-value: 3.67e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   45 VRLSGIVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQ--AVKNYSaklgyehpVAIALDTKGPEI 122
Cdd:PLN02762  24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRlnEEKGFA--------VAVMMDTEGSEI 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  123 RTGLIGGSGTAEIElkKGEkIKLTTNKEFLEKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVRE-VGKDsLTCEVE 201
Cdd:PLN02762  96 HMGDLGGASSAKAE--DGE-EWTFTVRKFDGSRPEFTIQVNYDGFAEDVKVGDELVVDGGMVRFEVIEkIGPD-VKCKCT 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  202 NGGSLGSRKGVNL--PGVPVD-----LPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEKGKN--IKIIS 272
Cdd:PLN02762 172 DPGLLLPRANLTFwrDGSLVRernamLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARSRDsdIGVIA 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  273 KIENQQGMHNLDEIIEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVA 352
Cdd:PLN02762 252 KIESLDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVS 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  353 NAVLDGADCVMLSGETAKGEYPLE--CVLTMAKTCKEaeaaLW------HQNLFNDLVRGAGTIDASHAAAIAAVEAATK 424
Cdd:PLN02762 332 EAVRQRADALMLSGESAMGLYPEKalSVLRSVSLRME----LWsreekrHEALELPQLSSSLSDRISEEICNSAAKMANN 407

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  425 AKASAIVVITTSGKSAFQVSKYRPRCPIIAVTRFAQTARQAHLYRGLVPLiykepgLGDWLKDVDVRVQFGLQVGKKNGF 504
Cdd:PLN02762 408 LGVDAIFVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPF------RLDFSDDMESNLNKTFSLLKARGM 481

                        490       500
                 ....*....|....*....|....*....
gi 28571814  505 IKTGDSVVVVTGWKQgSGFTNTIRIVTVE 533
Cdd:PLN02762 482 IKSGDLVIAVSDLTP-SSMLQSIQVRNVP 509
PRK08187 PRK08187
pyruvate kinase; Validated
 40-378 2.18e-55

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 193.69  E-value: 2.18e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   40 SPVPHVRLsgIVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAvknySAKLGyeHPVAIALDTKG 119
Cdd:PRK08187 130 PAARRTRI--MVTLPSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQA----ERATG--RRCKILMDLAG 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  120 PEIRTGLIGGsGTAEIELKKGEKIKLTTNKEFL-EKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDSLTC 198
Cdd:PRK08187 202 PKIRTGAVAG-PLGKTRLYTGDRLALVAQGPPRrIDEEHFQVTCTLPEILARLAVGARVWIDDGKLGARVERVGPGGALL 280

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  199 EV----ENGGSLGSRKGVNLPGVPVDLPAVSEKDKSDLLFgVEQEVDMIFASFIRNAAALTEIRKVLGEKGKN----IKI 270
Cdd:PRK08187 281 EVtharPKGLKLKPEKGLNFPDTALDLPALTEKDRADLDF-VARHADLVGYSFVQSPGDVEALQAALAARRPDdwrkLGL 359

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  271 ISKIENQQGMHNLDEIIEAGDG-----IMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTR 345
Cdd:PRK08187 360 VLKIETPRAVANLPELIVQAAGrqpfgVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSR 439

                        330       340       350
                 ....*....|....*....|....*....|...
gi 28571814  346 AEISDVANAvlDGADCVMLSgetaKGEYPLECV 378
Cdd:PRK08187 440 AEMTDAAMA--ARAECVMLN----KGPYLVEAV 466
PRK14725 PRK14725
pyruvate kinase; Provisional
 24-378 6.54e-47

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 172.83  E-value: 6.54e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   24 AGADTQLEHMCRLQFDSPvPHVRLSGIVCTI-GPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAvknyS 102
Cdd:PRK14725 118 EEGDELLDEHAEALLGPP-PSGRPTRIMVTLpTEAADDPDLVRRLLAAGMDIARINCAHDDPEAWRAMIANVRTA----E 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  103 AKLGyeHPVAIALDTKGPEIRTGLI-----------------------------GGSGTAEIE---------------LK 138
Cdd:PRK14725 193 EELG--RRCRIAMDLAGPKLRTGPIapgprviklrptrdalgrvltparlwltaSESPPPSPPpgpvglpvdpewlarLE 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  139 KGEKIKLT---------------------------------------------------TNKEFLEKGSLEIVYVDYE-- 165
Cdd:PRK14725 271 PGDELRFTdargkkrkltvtevddegvlaegsqtaylangtllrlgrhdstrvgglppvEQKLRLKVGDRLVLTRDDApg 350

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  166 -----------------NIVNVVKPGNRVFVDDGLISLIVREVGKDSLTCEVENGGSLGSR----KGVNLPGVPVDLPAV 224
Cdd:PRK14725 351 dpaqgdapparisctlpEAFRAARVGERVWFDDGKIGAVVVKVEADEVELRITHARPGGSKlkagKGINLPDSHLPLPAL 430

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  225 SEKDKSDLLFgVEQEVDMIFASFIRNAAALTEIRKVLGE-KGKNIKIISKIENQQGMHNLDEIIEAG-----DGIMVARG 298
Cdd:PRK14725 431 TDKDLEDLAF-VAKHADIVALSFVRSPEDVRLLLDALEKlGADDLGVVLKIETRRAFENLPRILLEAmrhprFGVMIARG 509

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  299 DLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLdgADCVMLSgetaKGEYPLECV 378
Cdd:PRK14725 510 DLAVEVGFERLAEVQEEILWLCEAAHVPVIWATQVLESLAKKGLPSRAEITDAAMALR--AECVMLN----KGPHIVEAV 583
PykA2 COG3848
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
319-532 2.76e-38

Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];


Pssm-ID: 443058  Cd Length: 321  Bit Score: 142.73  E-value: 2.76e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814 319 RCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGADCVMLSGETAKGEYPLECVLTMAKTCKEAEAALWHQNLF 398
Cdd:COG3848   1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYREQR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814 399 NDLVRGAGTiDASHAAAIAAVEAATKAKASAIVVITTSGKSAFQVSKYRPRCPIIAVTRFAQTARQAHLYRGLVPLIYKE 478
Cdd:COG3848  81 VPRAKESST-TITDAISHAVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVEE 159

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 28571814 479 pglgdwLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTGWKQG-SGFTNTIRIVTV 532
Cdd:COG3848 160 ------SASTDEMFAVAVALALEAGLVKDGDLVVITAGVPVGvSGTTNLLKVHVV 208
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
 426-530 7.44e-36

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 129.52  E-value: 7.44e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814   426 KASAIVVITTSGKSAFQVSKYRPRCPIIAVTRFAQTARQAHLYRGLVPLIYKEPglgdwlKDVDVRVQFGLQVGKKNGFI 505
Cdd:pfam02887  15 GAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEA------ETTDEMLRRAVKVAKEAGLV 88

                          90       100
                  ....*....|....*....|....*.
gi 28571814   506 KTGDSVVVVTGWKQG-SGFTNTIRIV 530
Cdd:pfam02887  89 KKGDLVVITAGVPFGvSGTTNTLKVI 114
PRK10558 PRK10558
alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional
 266-327 2.29e-04

alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional


Pssm-ID: 182547  Cd Length: 256  Bit Score: 43.19  E-value: 2.29e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571814  266 KNIKIISKIENQQGMHNLDEI--IEAGDGIMVARGDLGIEI-----PAE-KVFLAQKAMIARCNKAGKPV 327
Cdd:PRK10558 144 KNITVLVQIESQQGVDNVDAIaaTEGVDGIFVGPSDLAAALghlgnASHpDVQKAIQHIFARAKAHGKPS 213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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