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Conserved domains on  [gi|24656994|ref|NP_524809|]
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crossveinless 2 [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 371-536 4.48e-37

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


:

Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 136.38  E-value: 4.48e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656994    371 ECCQrCVETAGTCTVFGDPHFRTFDGKFFSFQGSCKYLLASDCM-GKTFHIRLTNEGRGTrRASWAKTVTLSLRNLKVNL 449
Cdd:smart00216   1 WCCT-QEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSsEPTFSVLLKNVPCGG-GATCLKSVKVELNGDEIEL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656994    450 GQRMR-VKVNGTRVTLPYFVvaggQNVTIERLANGGAVMLRSEMGL-TLEWNGAGFLQVSVPAKFKKRLCGLCGNFNGSS 527
Cdd:smart00216  79 KDDNGkVTVNGQQVSLPYKT----SDGSIQIRSSGGYLVVITSLGLiQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEP 154


                   ....*....
gi 24656994    528 RDDLTGKDG 536
Cdd:smart00216 155 EDDFRTPDG 163
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 580-646 5.75e-15

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


:

Pssm-ID: 462584  Cd Length: 68  Bit Score: 70.10  E-value: 5.75e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24656994   580 YCHPLSVPALFGECNERLNPENYKAACRMDVCECP-SGDCHCDSFAAYAHECRRLGVQLPDWRSATNC 646
Cdd:pfam08742   1 KCGLLSDSGPFAPCHSVVDPEPYFEACVYDMCSCGgDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
VWC smart00214
von Willebrand factor (vWF) type C domain;
319-376 7.15e-10

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 55.21  E-value: 7.15e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 24656994    319 CSLDGIVYQNNETWDMGPCRSCRC-NGGTIRCAQMRCPAVKCRANEELKQPPGECCQRC 376
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTClDGTTVLCDPVECPPPPDCPNPERVKPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 256-310 1.83e-07

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


:

Pssm-ID: 278520  Cd Length: 57  Bit Score: 48.19  E-value: 1.83e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 24656994   256 CLFNKSVYPEKTQFMPDRCTNCTCLNGTSVCQRPTCPILECA-PEFQEPDG-CCPRC 310
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPnPRLEIPPGeCCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
184-243 1.19e-06

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 45.97  E-value: 1.19e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24656994    184 CKINGQTVAEGHEVDasiDDRCLVCQC-RGTQLTCSKKTCP-VLPCPMSKQIKRPDECCPRC 243
Cdd:smart00214   1 CVHNGRVYNDGETWK---PDPCQICTClDGTTVLCDPVECPpPPDCPNPERVKPPGECCPRC 59
 
Name Accession Description Interval E-value
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 371-536 4.48e-37

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 136.38  E-value: 4.48e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656994    371 ECCQrCVETAGTCTVFGDPHFRTFDGKFFSFQGSCKYLLASDCM-GKTFHIRLTNEGRGTrRASWAKTVTLSLRNLKVNL 449
Cdd:smart00216   1 WCCT-QEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSsEPTFSVLLKNVPCGG-GATCLKSVKVELNGDEIEL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656994    450 GQRMR-VKVNGTRVTLPYFVvaggQNVTIERLANGGAVMLRSEMGL-TLEWNGAGFLQVSVPAKFKKRLCGLCGNFNGSS 527
Cdd:smart00216  79 KDDNGkVTVNGQQVSLPYKT----SDGSIQIRSSGGYLVVITSLGLiQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEP 154


                   ....*....
gi 24656994    528 RDDLTGKDG 536
Cdd:smart00216 155 EDDFRTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 383-537 3.05e-35

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 130.95  E-value: 3.05e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656994   383 CTVFGDPHFRTFDGKFFSFQGSCKYLLASDCMGKT-FHIRLTN-EGRGTRRASWAKTVTLSLRNLKVNLGQRMRVKVNGT 460
Cdd:pfam00094   1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPdFSFSVTNkNCNGGASGVCLKSVTVIVGDLEITLQKGGTVLVNGQ 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24656994   461 RVTLPYFVvaggQNVTIERLANGGA-VMLRSEMGLTLEWNGAGFLQVSVPAKFKKRLCGLCGNFNGSSRDDLTGKDGR 537
Cdd:pfam00094  81 KVSLPYKS----DGGEVEILGSGFVvVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 580-646 5.75e-15

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 70.10  E-value: 5.75e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24656994   580 YCHPLSVPALFGECNERLNPENYKAACRMDVCECP-SGDCHCDSFAAYAHECRRLGVQLPDWRSATNC 646
Cdd:pfam08742   1 KCGLLSDSGPFAPCHSVVDPEPYFEACVYDMCSCGgDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 590-647 1.17e-11

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 60.82  E-value: 1.17e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 24656994    590 FGECNERLNPENYKAACRMDVCECPSG-DCHCDSFAAYAHECRRLGVQLPDWRSATNCP 647
Cdd:smart00832  18 FAACHSVVDPEPFFENCVYDTCACGGDcECLCDALAAYAAACAEAGVCISPWRTPTFCP 76
VWC smart00214
von Willebrand factor (vWF) type C domain;
319-376 7.15e-10

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 55.21  E-value: 7.15e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 24656994    319 CSLDGIVYQNNETWDMGPCRSCRC-NGGTIRCAQMRCPAVKCRANEELKQPPGECCQRC 376
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTClDGTTVLCDPVECPPPPDCPNPERVKPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 319-376 3.97e-09

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 53.20  E-value: 3.97e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 24656994   319 CSLDGIVYQNNETWDMGPCRSCRCNGGTIRCAQMRCPAVKCrANEELKQPPGECCQRC 376
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDC-PNPRLEIPPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 256-310 1.83e-07

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 48.19  E-value: 1.83e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 24656994   256 CLFNKSVYPEKTQFMPDRCTNCTCLNGTSVCQRPTCPILECA-PEFQEPDG-CCPRC 310
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPnPRLEIPPGeCCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
184-243 1.19e-06

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 45.97  E-value: 1.19e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24656994    184 CKINGQTVAEGHEVDasiDDRCLVCQC-RGTQLTCSKKTCP-VLPCPMSKQIKRPDECCPRC 243
Cdd:smart00214   1 CVHNGRVYNDGETWK---PDPCQICTClDGTTVLCDPVECPpPPDCPNPERVKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
256-310 3.30e-06

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 44.81  E-value: 3.30e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 24656994    256 CLFNKSVYPEKTQFMPDRCTNCTCLNGTSV-CQRPTCPI-LECA-PEFQEPDG-CCPRC 310
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPpPDCPnPERVKPPGeCCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 184-243 9.33e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 40.87  E-value: 9.33e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656994   184 CKINGQTVAEGHEVDAsidDRCLVCQCRGTQLTCSKKTCPVLPCPMSKQIKRPDECCPRC 243
Cdd:pfam00093   1 CVQNGVVYENGETWKP---DLCTICTCDDGKVLCDKIICPPLDCPNPRLEIPPGECCPVC 57
 
Name Accession Description Interval E-value
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 371-536 4.48e-37

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 136.38  E-value: 4.48e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656994    371 ECCQrCVETAGTCTVFGDPHFRTFDGKFFSFQGSCKYLLASDCM-GKTFHIRLTNEGRGTrRASWAKTVTLSLRNLKVNL 449
Cdd:smart00216   1 WCCT-QEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSsEPTFSVLLKNVPCGG-GATCLKSVKVELNGDEIEL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656994    450 GQRMR-VKVNGTRVTLPYFVvaggQNVTIERLANGGAVMLRSEMGL-TLEWNGAGFLQVSVPAKFKKRLCGLCGNFNGSS 527
Cdd:smart00216  79 KDDNGkVTVNGQQVSLPYKT----SDGSIQIRSSGGYLVVITSLGLiQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEP 154


                   ....*....
gi 24656994    528 RDDLTGKDG 536
Cdd:smart00216 155 EDDFRTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 383-537 3.05e-35

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 130.95  E-value: 3.05e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656994   383 CTVFGDPHFRTFDGKFFSFQGSCKYLLASDCMGKT-FHIRLTN-EGRGTRRASWAKTVTLSLRNLKVNLGQRMRVKVNGT 460
Cdd:pfam00094   1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPdFSFSVTNkNCNGGASGVCLKSVTVIVGDLEITLQKGGTVLVNGQ 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24656994   461 RVTLPYFVvaggQNVTIERLANGGA-VMLRSEMGLTLEWNGAGFLQVSVPAKFKKRLCGLCGNFNGSSRDDLTGKDGR 537
Cdd:pfam00094  81 KVSLPYKS----DGGEVEILGSGFVvVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 580-646 5.75e-15

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 70.10  E-value: 5.75e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24656994   580 YCHPLSVPALFGECNERLNPENYKAACRMDVCECP-SGDCHCDSFAAYAHECRRLGVQLPDWRSATNC 646
Cdd:pfam08742   1 KCGLLSDSGPFAPCHSVVDPEPYFEACVYDMCSCGgDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 590-647 1.17e-11

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 60.82  E-value: 1.17e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 24656994    590 FGECNERLNPENYKAACRMDVCECPSG-DCHCDSFAAYAHECRRLGVQLPDWRSATNCP 647
Cdd:smart00832  18 FAACHSVVDPEPFFENCVYDTCACGGDcECLCDALAAYAAACAEAGVCISPWRTPTFCP 76
VWC smart00214
von Willebrand factor (vWF) type C domain;
319-376 7.15e-10

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 55.21  E-value: 7.15e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 24656994    319 CSLDGIVYQNNETWDMGPCRSCRC-NGGTIRCAQMRCPAVKCRANEELKQPPGECCQRC 376
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTClDGTTVLCDPVECPPPPDCPNPERVKPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 319-376 3.97e-09

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 53.20  E-value: 3.97e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 24656994   319 CSLDGIVYQNNETWDMGPCRSCRCNGGTIRCAQMRCPAVKCrANEELKQPPGECCQRC 376
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDC-PNPRLEIPPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 256-310 1.83e-07

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 48.19  E-value: 1.83e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 24656994   256 CLFNKSVYPEKTQFMPDRCTNCTCLNGTSVCQRPTCPILECA-PEFQEPDG-CCPRC 310
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPnPRLEIPPGeCCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
184-243 1.19e-06

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 45.97  E-value: 1.19e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24656994    184 CKINGQTVAEGHEVDasiDDRCLVCQC-RGTQLTCSKKTCP-VLPCPMSKQIKRPDECCPRC 243
Cdd:smart00214   1 CVHNGRVYNDGETWK---PDPCQICTClDGTTVLCDPVECPpPPDCPNPERVKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
256-310 3.30e-06

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 44.81  E-value: 3.30e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 24656994    256 CLFNKSVYPEKTQFMPDRCTNCTCLNGTSV-CQRPTCPI-LECA-PEFQEPDG-CCPRC 310
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPpPDCPnPERVKPPGeCCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 184-243 9.33e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 40.87  E-value: 9.33e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656994   184 CKINGQTVAEGHEVDAsidDRCLVCQCRGTQLTCSKKTCPVLPCPMSKQIKRPDECCPRC 243
Cdd:pfam00093   1 CVQNGVVYENGETWKP---DLCTICTCDDGKVLCDKIICPPLDCPNPRLEIPPGECCPVC 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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