|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
9-1094 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 1540.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 9 DVCRvPENINFPAEEENVLQKWRHENIFEKCSQLSKGKPKYTFYDGPPFATGLPHYGHILAGTIKDIVTRYAYQQGYHVD 88
Cdd:PLN02882 1 EVCE-GKDFSFPKQEEKILSLWSEIDAFKTQLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 89 RRFGWDCHGLPVEFEIDKLLNIKGPEDVAKMGIAAYNAECRKIVMRYADEWENVVTRVGRWIDFKNDYKTLYPWYMESIW 168
Cdd:PLN02882 80 RRFGWDCHGLPVEYEIDKKLGIKRRDDVLKMGIDKYNEECRSIVTRYSKEWEKTVTRTGRWIDFENDYKTMDPKFMESVW 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 169 WIFKQLFDKGLVYQGVKVMPYSTACTTSLSNFEANQNYKEVVDPCVVVALEAVSLP-NTFFLVWTTTPWTLPSNFACCVH 247
Cdd:PLN02882 160 WVFKQLFEKGLVYKGFKVMPYSTACKTPLSNFEAGLNYKDVSDPAVMVSFPIVGDPdNASFVAWTTTPWTLPSNLALCVN 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 248 PTMTYVKVRDVKSDRLFVLAESRLSYVY--------KSETE-----YEVKEKFVGKTLKDLHYKPLFPYFAkrGAEVKAY 314
Cdd:PLN02882 240 PNFTYVKVRNKYTGKVYIVAESRLSALPtakpkskkGSKPEnaaegYEVLAKVPGSSLVGKKYEPLFDYFS--EFSDTAF 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 315 RVLVDEYVTEDSGTGIVHNAPYFGEDDYRVCLAAGLITKSSEVLCPVDEAGRFTNEASDFEGQYVKDSDKQIMAALKARG 394
Cdd:PLN02882 318 RVVADDYVTDDSGTGVVHCAPAFGEDDYRVCLANGIIEKGGNLPVPVDDDGCFTEKVTDFSGRYVKDADKDIIAAIKAKG 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 395 NLVSSGQVKHSYPFCWRSDTPLIYKAVPSWFVRVEHMSKNLLDCSSQTYWVPDFVKEKRFGNWLKEARDWAISRNRYWGT 474
Cdd:PLN02882 398 RLVKSGSITHSYPFCWRSDTPLIYRAVPSWFVKVEEIKDRLLENNKQTYWVPDYVKEKRFHNWLENARDWAVSRSRFWGT 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 475 PIPIWRSPSGDETVVIGSIKQLAELSGVQVEDLHRESIDHIEIPSA-VPGNPPLRRIAPVFDCWFESGSMPFAQQHFPFE 553
Cdd:PLN02882 478 PLPIWISDDGEEVVVIGSIAELEKLSGVKVTDLHRHFIDHITIPSSrGPEFGVLRRVDDVFDCWFESGSMPYAYIHYPFE 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 554 NEKDFMNNFPADFIAEGIDQTRGWFYTLLVISTALFNKAPFKNLIASGLVLAADGQKMSKRKKNYPDPMEVVHKYGADAL 633
Cdd:PLN02882 558 NKELFEKNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDKYGADAL 637
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 634 RLYLINSPVVRAESLRFKEEGVRDIIKDVFLPWYNAYRFLLQNIVRYEKEDLAGNGQYTYDRERHLKNmdkasVIDVWIL 713
Cdd:PLN02882 638 RLYLINSPVVRAEPLRFKEEGVFGVVKDVFLPWYNAYRFLVQNAKRLEVEGGAPFVPLDLAKLQNSAN-----VLDRWIN 712
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 714 SFKESLLEFFATEMKMYRLYTVVPRLTKFIDQLTNWYVRLNRRRIKGELGADQCIQSLDTLYDVLYTMVKMMAPFTPYLT 793
Cdd:PLN02882 713 SATQSLVKFVREEMGAYRLYTVVPYLVKFIDNLTNIYVRFNRKRLKGRTGEEDCRTALSTLYNVLLTSCKVMAPFTPFFT 792
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 794 EYIFQRLVLFQPagtlEHADSVHYQMMPVSQKKFIRNDIERSVALMQSVVELGRVMRDRRTLPVKYPVSEIIAIHKDSQI 873
Cdd:PLN02882 793 EVLYQNLRKVLP----GSEESIHYCSFPQVDEGELDERIEQSVSRMQTVIELARNIRERHNKPLKTPLKEMVVVHPDAEF 868
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 874 LEAIK-TLQDFILSELNVRKLTLSSDKEKYgVTLRAEPDHKALGQRLKGNFKAVMAAIKALRDDEIQKQVSQGYFDILDQ 952
Cdd:PLN02882 869 LDDITgKLKEYVLEELNVRSLVPCNDPLKY-ASLRAEPNFSVLGKRLGKSMGLVAKEVKAMSQDDILEFEKAGEVTIAGH 947
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 953 RIELDEVRIIYCTSEQVG---GNFEAHSDNEVLVLLDMTPNEELLEEGLAREVINRVQKLKKKAQLIPTDPVLIFHELAA 1029
Cdd:PLN02882 948 TLKAGDIKVVRDFKRPEGvskEDIDAAGDGDVLVILDLRVDESLLEAGVAREVVNRIQKLRKKAGLEPTDKVEVFFESLD 1027
|
1050 1060 1070 1080 1090 1100
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24668547 1030 DNKakqevleaQAQLAKVLSNYASIIKTAIKSEFAPYSSEQASKKRLIASELVDLKGVPLKLTIC 1094
Cdd:PLN02882 1028 EVD--------ESALSQVLKSQAQYIRESLGSPLLPSSMMPSHAVVIAEESFHGVSGLSFKISLA 1084
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
13-1055 |
0e+00 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 1094.63 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 13 VPENINFPAEEENVLQKWRHENIFEKCSQLSKGKPKYTFYDGPPFATGLPHYGHILAGTIKDIVTRYAYQQGYHVDRRFG 92
Cdd:PTZ00427 68 VSENPNIVEEEEKVLKYWKSIDAFNTSNKLAKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFG 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 93 WDCHGLPVEFEIDKLLNIKGPEDVAKMGIAAYNAECRKIVMRYADEWENVVTRVGRWIDFKNDYKTLYPWYMESIWWIFK 172
Cdd:PTZ00427 148 WDCHGLPIEYEIEKENNINKKEDILKMGIDVYNEKCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFS 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 173 QLFDKGLVYQGVKVMPYSTACTTSLSNFEANQNYKEVVDPCVVVAL---------------------------------- 218
Cdd:PTZ00427 228 ELYKNNYVYKSFKVMPYSCKCNTPISNFELNLNYKDTPDPSIIISFvlcsdfpkveeecnieedkqllgekysvlynnkr 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 219 -----------EAVSLP-NTFFLVWTTTPWTLPSNFACCVHPTMTYVKVRDVKSDRLFVLAESRLSYVYKsETEYEVKE- 285
Cdd:PTZ00427 308 ensnngnnnstNNVCYAqHSEILAWTTTPWTLPSNLALCVNEHFTYLRIHHVKSNRVVIVGECRLEWIMK-ELKWNVEDl 386
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 286 ----KFVGKTLKDLHYKPLFPYF-AKRGAEVKAYRVLVDEYVTEDSGTGIVHNAPYFGEDDYRVCLAAGLITKSSEVLC- 359
Cdd:PTZ00427 387 kivnRFKGKELKGLRYKPLFTNFyEKYNFKERAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVIDPEKNIFId 466
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 360 PVDEAGRFTNEASDFEGQYVKDSDKQIMAALKARGNLVSSGQVKHSYPFCWRSDTPLIYKAVPSWFVRVEHMSKNLLDCS 439
Cdd:PTZ00427 467 PLDANGYFTNEVEEVQNLYIKEADNVIKKKLKNENRLLSNNTIVHSYPFCWRSDTPLIYRAIPAWFIRVSNSTNELVKNN 546
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 440 SQTYWVPDFVKEKRFGNWLKEARDWAISRNRYWGTPIPIWRSPSGDETVVIGSIKQLAELSGVQ-VEDLHRESIDHIEIP 518
Cdd:PTZ00427 547 ETTYWIPAHIKEKKFHNWIKDAKDWCISRNRYWGTPIPIWADEKMETVICVESIKHLEELSGVKnINDLHRHFIDHIEIK 626
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 519 SAVPGN-PPLRRIAPVFDCWFESGSMPFAQQHFPFENEK-DFMNNFPADFIAEGIDQTRGWFYTLLVISTALFNKAPFKN 596
Cdd:PTZ00427 627 NPKGKTyPKLKRIPEVFDCWFESGSMPYAKVHYPFSTEKeDFHKIFPADFIAEGLDQTRGWFYTLLVISTLLFDKAPFKN 706
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 597 LIASGLVLAADGQKMSKRKKNYPDPMEVVHKYGADALRLYLINSPVVRAESLRFKEEGVRDIIKDVFLPWYNAYRFLLQN 676
Cdd:PTZ00427 707 LICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLYLINSVAVRAENLKFQEKGVNEVVKSFILPFYHSFRFFSQE 786
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 677 IVRYEkedLAGNGQYTYDRERHLKNmdkASVIDVWILSFKESLLEFFATEMKMYRLYTVVPRLTKFIDQLTNWYVRLNRR 756
Cdd:PTZ00427 787 VTRYE---CLNKKQFLFNTDYIYKN---DNIMDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQFIENLTNWYIRLNRD 860
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 757 RIKGELGADQCIQSLDTLYDVLYTMVKMMAPFTPYLTEYIFQRLVLFQPAGT-LEHAD----------------SVHYQM 819
Cdd:PTZ00427 861 RMRGSLGEENCLQSLCTTYRTLHLFTVLMAPFTPFITEYIYQQLRRVKSTNEhNENNEtgntkegdlnrgvihkSVHFIM 940
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 820 MP-VSQKKFIRNDIERSVALMQSVVELGRVMRDRRTLPVKYPVSEIIAIHKDSQILEAIKTLQDFILSELNVRKLTLSSD 898
Cdd:PTZ00427 941 LPqVDEKYIIDYEIIELIEKMKDVILLGRVLRERRKVASKKPLKSITILHPNESYFKNFDQISNYIKEELNVLNVECSND 1020
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 899 KEkyGVTLRAEPDHKALGQRLKGNFKAVMAAIKALRDDEIQKQVSQGYFDILDQRIELDEVrIIYCTSEQVGGNFEAHSD 978
Cdd:PTZ00427 1021 TS--CLDFSAIPNYKTLGVKLGYNLKKVQNKIKNMDSESIKLYQQEGKITLDNVTLEGDDI-IIQMKPNFQNDNTDIISN 1097
|
1050 1060 1070 1080 1090 1100 1110
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24668547 979 NEVLVLLDMTPNEELLEEGLAREVINRVQKLKKKAQLIPTDPVLIfHELAADNKAKQEVLEAQAQLAKVLSNYASII 1055
Cdd:PTZ00427 1098 NYVTILMDFTTDQQLENMASARELCNHIQKMRKNLSLNQNSPVKM-HVYIADDTLRNNMVSEMEYIKKCLRRELNVI 1173
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
14-903 |
0e+00 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 988.04 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 14 PENINFPAEEENVLQKWRHENIFEKCSQLSKGKPKYTFYDGPPFATGLPHYGHILAGTIKDIVTRYAYQQGYHVDRRFGW 93
Cdd:COG0060 13 PMRANLPKREPEILKFWEENDIYEKSREARAGRPKFVLHDGPPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGW 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 94 DCHGLPVEFEIDKLLNIKGPeDVAKMGIAAYNAECRKIVMRYADEWENVVTRVGRWIDFKNDYKTLYPWYMESIWWIFKQ 173
Cdd:COG0060 93 DCHGLPIELKVEKELGIKKK-DIEKVGIAEFREKCREYALKYVDEQREDFKRLGVWGDWDNPYLTMDPEYEESIWWALKK 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 174 LFDKGLVYQGVKVMPYSTACTTSLSNFEAnqNYKEVVDPCVVVALEAVS------LPNTFFLVWTTTPWTLPSNFACCVH 247
Cdd:COG0060 172 LYEKGLLYKGLKPVPWCPRCGTALAEAEV--EYKDVTSPSIYVKFPVKDekalllLEDAYLVIWTTTPWTLPANLAVAVH 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 248 PTMTYVKVRdVKSDRLFVLAESRLSYVYK--SETEYEVKEKFVGKTLKDLHYKPLFPYFAKRGaevKAYRVLVDEYVTED 325
Cdd:COG0060 250 PDIDYVLVE-VTGGERLILAEALVEAVLKelGIEDYEVLATFKGAELEGLRYEHPFYYVVGYD---RAHPVILGDYVTTE 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 326 SGTGIVHNAPYFGEDDYRVCLAAGLitkssEVLCPVDEAGRFTNEASDFEGQYVKDSDKQIMAALKARGNLVSSGQVKHS 405
Cdd:COG0060 326 DGTGIVHTAPGHGEDDFEVGKKYGL-----PVLNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLKERGALLAREKITHS 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 406 YPFCWRSDTPLIYKAVPSWFVRVEHMSKNLLDCSSQTYWVPDFvKEKRFGNWLKEARDWAISRNRYWGTPIPIWRSPSGD 485
Cdd:COG0060 401 YPHCWRCKTPLIYRATPQWFISMDKLRDRALEAIEKVNWIPEW-GEGRFGNMLENRPDWCISRQRYWGVPIPIWVCEDCG 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 486 ETV----VIGSIKQLAELSGVQV---EDLHRESIDHiEIPSAVPGNpPLRRIAPVFDCWFESGSMPFAQqhfpFENEKDF 558
Cdd:COG0060 480 ELHrteeVIGSVAELLEEEGADAwfeLDLHRPFLDE-TLKCPKCGG-TMRRVPDVLDVWFDSGSMHFAV----LENREEL 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 559 mnNFPADFIAEGIDQTRGWFYTLLVISTALFNKAPFKNLIASGLVLAADGQKMSKRKKNYPDPMEVVHKYGADALRLYLI 638
Cdd:COG0060 554 --HFPADFYLEGSDQTRGWFYSSLLTSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVIDKYGADILRLWVA 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 639 NSPvvRAESLRFKEEGVRDiIKDVFLPWYNAYRFLLQNivryekedLAGngqytYDRERHLKNMDKASVIDVWILSFKES 718
Cdd:COG0060 632 SSD--YWGDLRFSDEILKE-VRDVYRRLRNTYRFLLAN--------LDD-----FDPAEDAVPYEDLPELDRWILSRLNE 695
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 719 LLEFFATEMKMYRLYTVVPRLTKFI-DQLTNWYVRLNRRRI-KGELGADQCIQSLDTLYDVLYTMVKMMAPFTPYLTEYI 796
Cdd:COG0060 696 LIKEVTEAYDNYDFHRAYRALHNFCvEDLSNWYLDISKDRLyTEAADSLDRRAAQTTLYEVLETLVRLLAPILPFTAEEI 775
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 797 FQRLvlfqpagTLEHADSVHYQMMPVSQKKFIRNDIERSVALMQSVVELGR----VMRDRRTlpVKYPVSEIIAIHKDSQ 872
Cdd:COG0060 776 WQNL-------PGEAEESVHLADWPEVDEELIDEELEAKWDLVREVRSAVLkaleAARKEKL--IRQPLEAAVVLYADEE 846
|
890 900 910
....*....|....*....|....*....|.
gi 24668547 873 ILEAIKTLQDFILSELNVRKLTLSSDKEKYG 903
Cdd:COG0060 847 LAAALESLGDLLAEELNVSEVELVDDAEDLG 877
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
12-878 |
0e+00 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 908.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 12 RVPENINFPAEEENVLQKWRHENIFEKCSQLSKGKPKYTFYDGPPFATGLPHYGHILAGTIKDIVTRYAYQQGYHVDRRF 91
Cdd:TIGR00392 1 KFPMRGNLSKREEKILAFWQENDIFEKVKKLNKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 92 GWDCHGLPVEFEIDKLLNIKGPEDVAKMGIAAYNAECRKIVMRYADEWENVVTRVGRWIDFKNDYKTLYPWYMESIWWIF 171
Cdd:TIGR00392 81 GWDTHGLPIEHKVEKKLGISGKKEISSLEIEEFREKCREFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 172 KQLFDKGLVYQGVKVMPYSTACTTSLSNFEANQ--NYKEVVDPCVVVALEAVSLPNT-------FFLVWTTTPWTLPSNF 242
Cdd:TIGR00392 161 KEAHEKGLLYRGLKPVYWSPRCRTALAEAEVEYkeNYKDVKDPSIYVKFPVKKDKKTylkvklsSLLIWTTTPWTLPSNL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 243 ACCVHPTMTYVKVRDVKSDRLFVLAESRLSYVYKSETE-YEVKEKFVGKTLKDLHYKPLFPYFAKRGAEVkAYRVLVDEY 321
Cdd:TIGR00392 241 AIAVHPDFEYALVQDNTKVEYFILAKKLVEKLYNKAGSdYEIIKTFKGSDLEGLEYEHPLYDFVSQLKEG-APVVIGGDH 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 322 VTEDSGTGIVHNAPYFGEDDYRVCLAAGLitkssEVLCPVDEAGRFTNEASDFEGQYVKDSDKQIMAA-------LKARG 394
Cdd:TIGR00392 320 VTTEDGTGIVHTAPGHGEEDYEIGKKYGL-----EVLSPVDEKGVYTEGVNDFQGRFVKDADKDIIKAnkiiieqLKDKG 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 395 NLVSSGQVKHSYPFCWRSDTPLIYKAVPSWFVRVEHMSKNLLDCSSQTYWVPDFVkEKRFGNWLKEARDWAISRNRYWGT 474
Cdd:TIGR00392 395 LLLKAEKITHSYPHCWRTKTPVIYRATEQWFIKTKDIKDQMLEQIKKVNWVPEWG-EGRFGNWLENRPDWCISRQRYWGI 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 475 PIPIWRSPSGDETVVIGSIKQLAE---LSGVQV--EDLHRESIDHIEIPSAVPGnpPLRRIAPVFDCWFESGSMPFAQQH 549
Cdd:TIGR00392 474 PIPIWYCEDTGEPIVVGSIEELIElieLKGIDAwfEDLHRDFLDKITLKSGDGG--EYRRVPDVLDVWFDSGSMPYASIH 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 550 FPFENEKdFMNNFPADFIAEGIDQTRGWFYTLLVISTALFNKAPFKNLIASGLVLAADGQKMSKRKKNYPDPMEVVHKYG 629
Cdd:TIGR00392 552 YPFENEK-FKEVFPADFILEGSDQTRGWFYSSLAIGTALFGQAPYKNVITHGFTLDEKGRKMSKSLGNVVDPLKVINKYG 630
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 630 ADALRLYLINSpvVRAESLRFKEEGVRDIIKDVFLPWYNAYRFLLQ--NIVRYekedlagNGQYTYDRERHLKNMDKasv 707
Cdd:TIGR00392 631 ADILRLYVASS--DPWEDLRFSDEILKQVVEKYRKIRWNTYRFLLTyaNLDKF-------DPLFNSVAVEKFPEEDR--- 698
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 708 idvWILSFKESLLEFFATEMKMYRLYTVVPRLTKFID-QLTNWYVRLNRRRIKGELGADQCIQSLDTLYDVLYTMVKMMA 786
Cdd:TIGR00392 699 ---WILSRLNSLVEEVNEALEKYNFHKVLRALQDFIVeELSNWYIRIIRDRLYCEAKDNDKRAAQTTLYYALLTLVRLLA 775
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 787 PFTPYLTEYIFQRLVlfqpagTLEHADSVHYQMMPVSQKKFIRNDIERSVALMQSVVELGRVMRDRRTLPVKYPVSEIIA 866
Cdd:TIGR00392 776 PFLPHTAEEIYQNLP------GGEEEESVHLNLWPEVDEEFIDEALEANMAIVREIVEAFLALRDAANKKLRQPLKELVI 849
|
890
....*....|..
gi 24668547 867 IHKDSQILEAIK 878
Cdd:TIGR00392 850 GKSLEAVLKAVE 861
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
26-649 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 804.32 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 26 VLQKWRHENIFEKCSQLSKGKPKYTFYDGPPFATGLPHYGHILAGTIKDIVTRYAYQQGYHVDRRFGWDCHGLPVEFEID 105
Cdd:pfam00133 2 IYEFWDEQGYFKPELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVVE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 106 KLLNIKGPEDVAKMGIAAYNAECRKIVMRYADEWENVVTRVGRWIDFKNDYKTLYPWYMESIWWIFKQLFDKGLVYQGVK 185
Cdd:pfam00133 82 KKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGKK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 186 VMPYSTACTTSLSNFEAnqNYKEVVDPCVVVALEAVSLPNTFFLVWTTTPWTLPSNFACCVHPTMTYvkvrdVKSDRLFV 265
Cdd:pfam00133 162 LVNWSPALNTALSNLEV--EYKDVKGPSIHVAFPLADDEGASLVIWTTTPWTLPGNTAVAVNPEFDY-----VITGEGYI 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 266 LAESRLSYVYKSETEYEVKEKFVGKTLKDLHYKPLFpyfakrgaEVKAYRVLVDEYVTEDSGTGIVHNAPYFGEDDYRVC 345
Cdd:pfam00133 235 LAEALLKSLYKKGTDKKILEDFRGKELEGKEAIHPF--------VNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVG 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 346 LAAGLitkssEVLCPVDEAGRFTNEASDFEGQYVKDSDKQIMAALKARGNLVSSGQVKHSYPFCWRSDTPLIYKAVPSWF 425
Cdd:pfam00133 307 QRHNL-----EVINPVDDDGTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWF 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 426 VRVEHMSKNLLDCSSQTYWVPDFvKEKRFGNWLKEARDWAISRNRYWGTPIPIWRSPSGDETVVIGSIKQLAEL---SGV 502
Cdd:pfam00133 382 VRMDELADQALEAVEKVQFVPKS-GEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVCRGELFELVAGrfeEEG 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 503 QVEDLHRESIDHIEIPSAVpgnppLRRIAPVFDCWFESGSMPFAQQHFPFENEKDFMNNFPADFIAEGIDQTRGWFYTLL 582
Cdd:pfam00133 461 SIKWLHREAKDKLGYGKGT-----LEQDEDVLDTWFSSGSWPFSTLGWPFVNTEEFKKFFPADMLLEGSDQTRGWFYRMI 535
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24668547 583 VISTALFNKAPFKNLIASGLVLAADGQKMSKRKKNYPDPMEVVHKYGADALRLYLINSPVVRAESLR 649
Cdd:pfam00133 536 MLSTALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLANSDYGRDINLS 602
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
14-945 |
9.17e-111 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 367.85 E-value: 9.17e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 14 PENINFPAEEENVLQKWRHENIFEkcSQLSKGKPKYTFYDGPPFATGLPHYGHILAGTIKDIVTRYAYQQGYHVDRRFGW 93
Cdd:TIGR00422 2 PKDYDPHEVEKKWYKKWEKSGFFK--PDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 94 DCHGLPVEFEIDKLLNIKGPE--DVakmGIAAYNAECRKIVMRYADEWENVVTRVGRWIDFKNDYKTLYPWYMESIWWIF 171
Cdd:TIGR00422 80 DHAGIATQVKVEKKLGAEGKTkhDL---GREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 172 KQLFDKGLVYQGVKVMPYSTACTTSLSNFEANqnYKEVVDPCVVVALEAVSLPNTFFLVWTTTPWTLPSNFACCVHPtmt 251
Cdd:TIGR00422 157 VRLYEKGLIYRGEYLVNWDPKLNTAISDIEVE--YKEVKGKLYYIRYPLANGSKDYLVVATTRPETMFGDTAVAVHP--- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 252 yvkvrdvKSDRlfvlaesrlsyvYKSeteyevkekFVGKTLKDlhykPLFPYfakrgaEVKayrVLVDEYVTEDSGTGIV 331
Cdd:TIGR00422 232 -------EDER------------YKH---------LIGKKVIL----PLTGR------KIP---IIADEYVDMEFGTGAV 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 332 HNAPYFGEDDYRVCLAAGLitkssEVLCPVDEAGRFTNEASDFEGQYVKDSDKQIMAALKARGNLVSSGQVKHSYPFCWR 411
Cdd:TIGR00422 271 KVTPAHDFNDYEWGKRHNL-----EFINILDEDGLLNENAGKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWR 345
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 412 SDTPLIYKAVPSWFVRVEHMSKNLLDC--SSQTYWVPDFVkEKRFGNWLKEARDWAISRNRYWGTPIPIWRSPSGDETVV 489
Cdd:TIGR00422 346 SGTVVEPLLSKQWFVKVEKLADKALEAaeEGEIKFVPKRM-EKRYLNWLRNIKDWCISRQLIWGHRIPVWYCKECGEVYV 424
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 490 IGSikqlaelsgvqvEDLHREsidhieiPSAVPGNPPLRRIAPVFDCWFESGSMPFAQQHFPfENEKDFMNNFPADFIAE 569
Cdd:TIGR00422 425 AKE------------EPLPDD-------KTNTGPSVELEQDTDVLDTWFSSSLWPFSTLGWP-DETKDLKKFYPTDLLVT 484
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 570 GIDQTRGWFYTLLVISTALFNKAPFKNLIASGLVLAADGQKMSKRKKNYPDPMEVVHKYGADALRLYLINSpVVRAESLR 649
Cdd:TIGR00422 485 GYDIIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASL-VTPGDDIN 563
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 650 FKEEGVRDIIKdvFL-PWYNAYRFLLQNIvryeKEDLAGNGqytydrerhlkNMDKASVIDVWILSFKESLLEFFATEMK 728
Cdd:TIGR00422 564 FDWKRVESARN--FLnKLWNASRFVLMNL----SDDLELSG-----------GEEKLSLADRWILSKLNRTIKEVRKALD 626
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 729 MYRLYTVVPRLTKFI-DQLTNWYVRLNRRRIKGELGADQcIQSLDTLYDVLYTMVKMMAPFTPYLTEYIFQRLVlfqpag 807
Cdd:TIGR00422 627 KYRFAEAAKALYEFIwNDFCDWYIELVKYRLYNGNEAEK-KAARDTLYYVLDKALRLLHPFMPFITEEIWQHFK------ 699
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 808 tlEHADSVHYQMMPVSQKKFIRNDIERSVALMQSVVELGRVMRDRRTLPVKYPVsEIIAIHKDSQILEAIKTLQDFILSE 887
Cdd:TIGR00422 700 --EGADSIMLQSYPVVDAEFVDEEAEKAFELLKEIIVSIRNLKAESNIPPNAPL-KVLLIYTEAETAERLKLNAVDIKGA 776
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24668547 888 LNVRKLTLSSDKEKYGVTL-RAEPDHKALGQR--LKGNFKAVMAAIKALRDDEIQKQVSQG 945
Cdd:TIGR00422 777 INFSEVEVVIEKPEVTEAVvELVPGFEIIIPVkgLINKAKELARLQKQLDKEKKEVIRIEG 837
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
8-815 |
9.73e-109 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 365.25 E-value: 9.73e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 8 NDVCRVPEninfpaeeenvLQKWRHEN-IFEKCSQLSKGKPkYTFYDGPPFATGLPHYGHILAGTIKDIVTRYAYQQGYH 86
Cdd:PLN02843 4 NSVTREPE-----------IQKLWEENqVYKRVSDRNNGES-FTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKK 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 87 VDRRFGWDCHGLPVEFeidKLLNIKGPEDVAKMGIAAYNAECRKIVMRYADEWENVVTRVGRWIDFKNDYKTLYPWYMES 166
Cdd:PLN02843 72 VHYVPGWDCHGLPIEL---KVLQSLDQEARKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 167 IWWIFKQLFDKGLVYQGVKVMPYSTACTTSLSnfEANQNYKE-VVDPCVVVALEAVS------------LPNTFFLVWTT 233
Cdd:PLN02843 149 QIEVFGQMFLNGYIYRGRKPVHWSPSSRTALA--EAELEYPEgHVSKSIYVAFPVVSpsetspeeleefLPGLSLAIWTT 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 234 TPWTLPSNFACCVHPTMTY--VKVRDVKSD----------------------RLFVLAESRLSYVYKSETEYEVKEKFVG 289
Cdd:PLN02843 227 TPWTMPANAAVAVNDKLQYsvVEVQSFSEDestsggnkkkrpgnvlkeqqklFLIVATDLVPALEAKWGVKLVVLKTFPG 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 290 KTLKDLHYK-PLFPyfakRGAEVkayrVLVDEYVTEDSGTGIVHNAPYFGEDDYRVCLAAGLitkssEVLCPVDEAGRFT 368
Cdd:PLN02843 307 SDLEGCRYIhPLYN----RESPV----VIGGDYITTESGTGLVHTAPGHGQEDYITGLKYGL-----PLLSPVDDAGKFT 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 369 NEASDFEGQYV-KDSDKQIMAALKARGNLVSSGQVKHSYPFCWRSDTPLIYKAVPSWFVRVEHMSKNLLDCSSQTYWVPD 447
Cdd:PLN02843 374 EEAGQFSGLSVlGEGNAAVVEALDEAGSLLMEEAYGHKYPYDWRTKKPTIFRATEQWFASVEGFRQAALDAIDKVKWIPA 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 448 fVKEKRFGNWLKEARDWAISRNRYWGTPIPIWRSPSGDETVV----IGSIKQLAELSG------VQVEDLHRESIDHIEi 517
Cdd:PLN02843 454 -QGENRIRAMVSGRSDWCISRQRTWGVPIPVFYHVETKEPLMneetIAHVKSIVAQKGsdawwyMDVEDLLPEKYRDKA- 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 518 psavpgnPPLRRIAPVFDCWFESGSMPFAqqhfPFENEKDFmnNFPADFIAEGIDQTRGWFYTLLVISTALFNKAPFKNL 597
Cdd:PLN02843 532 -------SDYEKGTDTMDVWFDSGSSWAG----VLGSREGL--SYPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSV 598
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 598 IASGLVLAADGQKMSKRKKNYPDPMEVVH---------KYGADALRLY----------LINSPVVRAESlrfkeegvrdi 658
Cdd:PLN02843 599 LTHGFVLDEKGFKMSKSLGNVVDPRLVIEggknqkqepAYGADVLRLWvasvdytgdvLIGPQILKQMS----------- 667
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 659 ikDVFLPWYNAYRFLLQNIVRYEKEDlagngQYTYDrerHLKNMDKasvidvWILSFKESLLEFFATEMKMYRLYTVVPR 738
Cdd:PLN02843 668 --DIYRKLRGTLRYLLGNLHDWKPDN-----AVPYE---DLPSIDK------YALFQLENVVNEIEESYDNYQFFKIFQI 731
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24668547 739 LTKF-IDQLTNWYVRLNRRRIKGELGADQCIQSLDT-LYDVLYTMVKMMAPFTPYLTEYIFQRLVlFQPAGTLehADSV 815
Cdd:PLN02843 732 LQRFtIVDLSNFYLDVAKDRLYVGGTTSFTRRSCQTvLAAHLLSLLRAIAPILPHLAEDAWQNLP-FQEDGSA--AESV 807
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
373-650 |
7.84e-108 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 342.67 E-value: 7.84e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 373 DFEGQYVKDSDKQIMAALKARGNLVSSGQVKHSY-PFCWrsdtPLIYKAVPSWFVRVEHMSKNLLDCSSQTYWVPDFVKE 451
Cdd:cd00818 105 DWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYkVVPW----PLIYRATPQWFIRVTKIKDRLLEANDKVNWIPEWVKN 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 452 kRFGNWLKEARDWAISRNRYWGTPIPIWRSPSGDETVVigsikqlaelsgvqvedlhresidhieipsavpgnpplRRIA 531
Cdd:cd00818 181 -RFGNWLENRRDWCISRQRYWGTPIPVWYCEDCGEVLV--------------------------------------RRVP 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 532 PVFDCWFESGSMPFAQQHFPFENEkDFMNNFPADFIAEGIDQTRGWFYTLLVISTALFNKAPFKNLIASGLVLAADGQKM 611
Cdd:cd00818 222 DVLDVWFDSGSMPYAQLHYPFENE-DFEELFPADFILEGSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKM 300
|
250 260 270
....*....|....*....|....*....|....*....
gi 24668547 612 SKRKKNYPDPMEVVHKYGADALRLYLINSPvVRAESLRF 650
Cdd:cd00818 301 SKSLGNYVDPQEVVDKYGADALRLWVASSD-VYAEDLRF 338
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
12-901 |
4.68e-94 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 320.22 E-value: 4.68e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 12 RVPENINFPAEEENVLQKWRHENIFEKcsQLSKGKPKYTFYDGPPFATGLPHYGHILAGTIKDIVTRYAYQQGYHVDRRF 91
Cdd:PRK13208 5 ELPKKYDPEELEEKWQKIWEEEGTYKF--DPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 92 GWDCHGLPVEFEIDKLLNIK----GPEDVAKMgiaaynaeCRKIVMRYADEWENVVTRVGRWIDFKNDYKTLYPWYMESI 167
Cdd:PRK13208 83 GWDDNGLPTERKVEKYYGIRkddiSREEFIEL--------CRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRIS 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 168 WWIFKQLFDKGLVYQGVKVMPYSTACTTSLSnfEANQNYKE------------VVDPCVVVAleavslpntfflvwTTTP 235
Cdd:PRK13208 155 QKSFLDLYKKGLIYRAEAPVLWCPRCETAIA--QAEVEYREregklnyikfpvEDGEEIEIA--------------TTRP 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 236 WTLPsnfACC---VHPtmtyvkvRDvksDRlfvlaesrlsyvYKseteyevkeKFVGKTLKdlhyKPLFpyfakrGAEVK 312
Cdd:PRK13208 219 ELLP---ACVavvVHP-------DD---ER------------YK---------HLVGKTAI----VPLF------GVEVP 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 313 ayrVLVDEYVTEDSGTGIVHNAPYFGEDDYRVCLAAGLITKSSevlcpVDEAGRFTNEASDFEGQYVKDSDKQIMAALKA 392
Cdd:PRK13208 255 ---ILADPLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRII-----IDEDGRMTEAAGKLAGLTIEEARKKIVEDLKS 326
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 393 RGNLVSSGQVKHSYPFCWRSDTPLIYKAVPSWFVRVEHMSKNLLDCSSQTYWVPDFVKeKRFGNWLKE-ARDWAISRNRY 471
Cdd:PRK13208 327 GGLLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLERGKEINWYPEHMR-VRLENWIEGlNWDWCISRQRY 405
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 472 WGTPIPIWRSPSGDETVVigsikqlAElsgvqVEDLhreSIDhieiPSAVPgnPP--------LRRIAP---VFDCWFES 540
Cdd:PRK13208 406 FGTPIPVWYCKDCGHPIL-------PD-----EEDL---PVD----PTKDE--PPgykcpqcgSPGFEGetdVMDTWATS 464
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 541 GSMPFAQQHFPfENEKDFMNNFPADFIAEGIDQTRGW-FYTLLViSTALFNKAPFKNLIASGLVLAADGQKMSKRKKNYP 619
Cdd:PRK13208 465 SITPLIVTGWE-RDEDLFEKVFPMDLRPQGHDIIRTWlFYTILR-AYLLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVV 542
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 620 DPMEVVHKYGADALRLYLINSPVvrAESLRFKEEGV----RDIIKdvflpWYNAYRFLLQNIVRYEKedlagngqytydr 695
Cdd:PRK13208 543 TPEELLEKYGADAVRYWAASARL--GSDTPFDEKQVkigrRLLTK-----LWNASRFVLHFSADPEP------------- 602
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 696 erhlknmDKASV---IDVWILSFKESLLEFFATEMKMYRLYTVVPRLTKFI-DQLTNWYVRLNRRRIKGELGADQCIQSL 771
Cdd:PRK13208 603 -------DKAEVlepLDRWILAKLAKVVEKATEALENYDFAKALEEIESFFwHVFCDDYLELVKSRAYGEDEEEEQKSAR 675
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 772 DTLYDVLYTMVKMMAPFTPYLTEYIFQRLvlfqpagtleHADSVHYQMMPVSQKKFIRNDIERSVALMQSVVELGRVMRD 851
Cdd:PRK13208 676 YTLYTVLDTLLRLLAPFLPFITEEVWSWL----------YGGSVHRASWPEPDEELIDEEDEELGELAKEILSAVRKYKS 745
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|..
gi 24668547 852 RRTLPVKYPVS--EIIAIHKDSQILEAIKTLQDFilseLNVRKLTLSSDKEK 901
Cdd:PRK13208 746 EAGLSLNAPLKkvEVYGPADLELLEAAEEDLKAA----GNIEELELVEGDPE 793
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
47-189 |
3.73e-85 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 280.66 E-value: 3.73e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 47 PKYTFYDGPPFATGLPHYGHILAGTIKDIVTRYAYQQGYHVDRRFGWDCHGLPVEFEIDKLLNIKGPEDVAKMGIAAYNA 126
Cdd:cd00818 1 PEFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEKMGIAEFNA 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24668547 127 ECRKIVMRYADEWENVVTRVGRWIDFKNDYKTLYPWYMESIWWIFKQLFDKGLVYQGVKVMPY 189
Cdd:cd00818 81 KCREFALRYVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW 143
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
650-847 |
4.88e-76 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 249.01 E-value: 4.88e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 650 FKEEGVRDIIKDVFLPWYNAYRFLLQNIVRYEkedlagngqytYDRERHLKNMDKASVIDVWILSFKESLLEFFATEMKM 729
Cdd:cd07961 1 FSEKGVREVVRKVLLPLWNAYRFFVTYANLDG-----------FDPGKDDDAVASLNVLDRWILSRLNSLIKEVTEEMEA 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 730 YRLYTVVPRLTKFIDQLTNWYVRLNRRRIKGELGADQCIQSLDTLYDVLYTMVKMMAPFTPYLTEYIFQRLVLFQPagtl 809
Cdd:cd07961 70 YDLYTAVRALLEFIDELTNWYIRRNRKRFWGEEGDDDKLAAYATLYEVLLTLSRLMAPFTPFITEEIYQNLRRELG---- 145
|
170 180 190
....*....|....*....|....*....|....*...
gi 24668547 810 EHADSVHYQMMPVSQKKFIRNDIERSVALMQSVVELGR 847
Cdd:cd07961 146 DAPESVHLLDWPEVDESLIDEELEEAMELVREIVELGR 183
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
30-858 |
5.80e-53 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 202.91 E-value: 5.80e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 30 WRHENIFeKCSQLSKGKPKYTFYDGPPFATGLPHYGHILAGTIKDIVTRYAYQQGYHVDRRFGWDCHGLPVEFEIDKLLn 109
Cdd:PRK14900 32 WQERGYF-HGDEHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGIATQMIVEKEL- 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 110 iKGPEDVAKMGIAaynaecRKIVMRYADEW-ENVVTRVGRW-------IDFKNDYKTLYPWYMESIWWIFKQLFDKGLVY 181
Cdd:PRK14900 110 -KKTEKKSRHDLG------REAFLERVWAWkEQYGSRIGEQhkalgasLDWQRERFTMDEGLSRAVREVFVRLHEEGLIY 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 182 QGVKVMPYSTACTTSLSNFEANqnYKEVVDPCVVVALEAVSLPNTFFLVWTTTPWTLPSNFACCVHPTmtyvkvrdvksd 261
Cdd:PRK14900 183 REKKLINWCPDCRTALSDLEVE--HEEAHQGELWSFAYPLADGSGEIVVATTRPETMLGDTAVAVHPL------------ 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 262 rlfvlaesrlsyvykseteyevKEKFvgktlKDLHYKPLFPYFAKRGAEVKAYRVLVDEYVtedsGTGIVHNAPYFGEDD 341
Cdd:PRK14900 249 ----------------------DPRY-----MALHGKKVRHPITGRTFPIVADAILVDPKF----GTGAVKVTPAHDFND 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 342 YRVCLAAGLitkssEVLCPVDEAGRFTNEASDFEGQYVKDSDKQIMAALKARGnlVSSGQVKHSYPF--CWRSDTPLIYK 419
Cdd:PRK14900 298 FEVGKRHGL-----EMITVIGPDGRMTAEAGPLAGLDRFEARKEVKRLLAEQG--LDRGAKPHVLPLgrCQRSATILEPL 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 420 AVPSWFVRVEHMSKNLLDCSSQ--TYWVPDFVKEKRFGnWLKEARDWAISRNRYWGTPIPIWRSPSGDETVVigsikqla 497
Cdd:PRK14900 371 LSDQWYVRIEPLARPAIEAVEQgrTRFIPEQWTNTYMA-WMRNIHDWCISRQLWWGHQIPAWYCPDGHVTVA-------- 441
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 498 elsgvqvedlhRESidhieiPSAVP--GNPPLRRIAPVFDCWFESGSMPFAQQHFPfENEKDFMNNFPADFIAEGIDQTR 575
Cdd:PRK14900 442 -----------RET------PEACStcGKAELRQDEDVLDTWFSSGLWPFSTMGWP-EQTDTLRTFYPTSVMETGHDIIF 503
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 576 GWFYTLLVISTALFNKAPFKNLIASGLVLAADGQKMSKRKKNYPDPMEVVHKYGADALRLYLInSPVVRAESLRFKE--- 652
Cdd:PRK14900 504 FWVARMMMMGLHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADALRFTLA-ALTAQGRDIKLAKeri 582
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 653 EGVRDIIKDVflpwYNAYRFLLQNIVRYEkedlagngqytyDRERHLKNMDKaSVIDVWILSFKESLLEFFATEMKMYRL 732
Cdd:PRK14900 583 EGYRAFANKL----WNASRFALMNLSGYQ------------ERGEDPARLAR-TPADRWILARLQRAVNETVEALEAFRF 645
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 733 YTVVPRLTKFI-DQLTNWYVRLNRRRIKGE-LGADQCIQSldTLYDVLYTMVKMMAPFTPYLTEYIFQrlVLFQPAGTLE 810
Cdd:PRK14900 646 NDAANAVYAFVwHELCDWYIELAKEALASEdPEARRSVQA--VLVHCLQTSYRLLHPFMPFITEELWH--VLRAQVGASA 721
|
810 820 830 840
....*....|....*....|....*....|....*....|....*...
gi 24668547 811 HADSVHYQMMPvsQKKFIRNDIERSVALMQSVVELGRVMRDRRTLPVK 858
Cdd:PRK14900 722 WADSVLAAEYP--RKGEADEAAEAAFRPVLGIIDAVRNIRGEMGIPWK 767
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
20-901 |
2.78e-52 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 199.18 E-value: 2.78e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 20 PAE-EENVLQKWRHENIFEkcSQLSKGKPkYTFYDGPPFATGLPHYGHILAGTIKDIVTRYAYQQGYHVDrrfgWdchgL 98
Cdd:PRK05729 11 PKEvEAKWYQKWEEKGYFK--PDDNSKKP-FSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTL----W----L 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 99 P------------VEfeidKLLNIKGP--EDvakMGiaaynaecR----KIVMRYADEWENVVT----RVGRWIDFKNDY 156
Cdd:PRK05729 80 PgtdhagiatqmvVE----RQLAAEGKsrHD---LG--------RekflEKVWEWKEESGGTITnqlrRLGASCDWSRER 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 157 KTLYPWYMESIWWIFKQLFDKGLVYQGVKVMPYSTACTTSLSNFEANqnYKEV-----------VDP--CVVVAleavsl 223
Cdd:PRK05729 145 FTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEVE--YKEVkgklwhiryplADGsdYLVVA------ 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 224 pntfflvwTTTPWTLPSNFACCVHPtmtyvkvrdvKSDRlfvlaesrlsyvYKSeteyevkekFVGKTLKdLhykPLfpy 303
Cdd:PRK05729 217 --------TTRPETMLGDTAVAVNP----------EDER------------YKH---------LIGKTVI-L---PL--- 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 304 fAKRgaEVKayrVLVDEYVTEDSGTGIV-----HNapyfgEDDYRVCLAAGLitkssEVLCPVDEAGRFTNEASDFEGQY 378
Cdd:PRK05729 251 -VGR--EIP---IIADEYVDPEFGTGAVkitpaHD-----PNDFEVGKRHNL-----PMINIMDEDGTINENPGEYQGLD 314
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 379 VKDSDKQIMAALKARGNLVSSGQVKHSYPFCWRSDT---PLIYKavpSWFVRVEHMSKNLLDC--SSQTYWVPD-FvkEK 452
Cdd:PRK05729 315 RFEARKAIVADLEELGLLVKIEPHTHSVGHSDRSGVviePYLSD---QWFVKMKPLAKPALEAveNGEIKFVPErW--EK 389
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 453 RFGNWLKEARDWAISRNRYWGTPIPIWRSPSGDETVvigsikqlaelsgvqvedlhresidhIEIPSAVPGNPPLRRIAP 532
Cdd:PRK05729 390 TYFHWMENIQDWCISRQLWWGHRIPAWYDEDGEVYV--------------------------GREEPEAREKALLTQDED 443
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 533 VFDCWFESGSMPFAQQHFPfENEKDFMNNFPADfiaegidqtrgwfytLLV----I-----------STALFNKAPFKNL 597
Cdd:PRK05729 444 VLDTWFSSALWPFSTLGWP-EKTEDLKRFYPTS---------------VLVtgfdIiffwvarmimmGLHFTGQVPFKDV 507
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 598 IASGLVLAADGQKMSKRKKNYPDPMEVVHKYGADALRLYLI--NSPvvrAESLRFKE---EGVRDIIKDVFlpwyNAYRF 672
Cdd:PRK05729 508 YIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAalASP---GRDIRFDEervEGYRNFANKLW----NASRF 580
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 673 LLQNIVRYEKEDLAGNgqytydrerhlknmDKASVIDVWILSFKESLLEFFATEMKMYRLYTVVPRLTKFI-DQLTNWYV 751
Cdd:PRK05729 581 VLMNLEGADVGELPDP--------------EELSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFIwNEFCDWYL 646
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 752 RLnrrrIKGELGADQCIQSLDTLYDVLYTMVKMMAPFTPYLTEYIFQRLVLFQPAGTLEHADsvhyqmMPVSQKKFiRND 831
Cdd:PRK05729 647 EL----AKPVLQEAAKRATRATLAYVLEQILRLLHPFMPFITEELWQKLAPLGIEESIMLAP------WPEADEAI-DEA 715
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 832 IERSVALMQSVVELGRVMRDRRTLPVKYPVsEIIAIHKDSQILEAIKTLQDFILSELNVRKLTLSSDKEK 901
Cdd:PRK05729 716 AEAEFEWLKELITAIRNIRAEMNIPPSKKL-PLLLKGADAEDRARLEANEAYIKRLARLESLEILADDEE 784
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
170-900 |
1.33e-48 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 187.95 E-value: 1.33e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 170 IFKQLFDKGLVYQGVKVMPYSTACTTSLSNFEANqnYKEVV-------------DPCVVVAleavslpntfflvwTTTPW 236
Cdd:COG0525 157 VFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVE--HEEVKghlwhirypladgSGYIVVA--------------TTRPE 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 237 TLPSNFACCVHPtmtyvkvrdvKSDRlfvlaesrlsyvYKSeteyevkekFVGKTLKdLhykPLfpyfakRGAEVKayrV 316
Cdd:COG0525 221 TMLGDTAVAVHP----------EDER------------YKH---------LIGKTVI-L---PL------VGREIP---I 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 317 LVDEYVTEDSGTGIV-----H--NapyfgedDYRVCLAAGLitkssEVLCPVDEAGRFTNEASDFEGQYVKDSDKQIMAA 389
Cdd:COG0525 257 IADEYVDPEFGTGAVkitpaHdpN-------DFEVGKRHNL-----PMINILDEDGTINENAGKYRGLDRFEARKAIVAD 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 390 LKARGNLVSSGQVKHSYPFCWRSDT---PLIykavpS--WFVRVEHMSKNLLDC--SSQTYWVPD-FvkEKRFGNWLKEA 461
Cdd:COG0525 325 LEELGLLVKVEPHKHSVGHSDRSGTviePYL-----SdqWFVKMKPLAKPAIEAveDGEIKFVPErW--EKTYFHWMENI 397
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 462 RDWAISRNRYWGTPIPIWRSPSGDETVVIGSIKQLAELSGvqvEDLHRESiDhieipsavpgnpplrriapVFDCWFESG 541
Cdd:COG0525 398 RDWCISRQLWWGHRIPAWYCPDGEVYVARTEPEACAKAGS---VNLTQDE-D-------------------VLDTWFSSA 454
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 542 SMPFAQQHFPFENE--KDFmnnFPADfiaegidqtrgwfytLLVisTA---LF--------------NKAPFKNLIASGL 602
Cdd:COG0525 455 LWPFSTLGWPEKTEdlKYF---YPTS---------------VLV--TGfdiIFfwvarmimmglhftGEVPFKDVYIHGL 514
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 603 VLAADGQKMSKRKKNYPDPMEVVHKYGADALRLYLI--NSPvvrAESLRFKE---EGVRD----IikdvflpWyNAYRFL 673
Cdd:COG0525 515 VRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAalASP---GRDIKFDEervEGYRNfankL-------W-NASRFV 583
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 674 LQNIVRYEKEDLAGNgqytydrerhlknmDKASVIDVWILS-FKESLLEfFATEMKMYRLYTVVPRLTKFI-DQLTNWYV 751
Cdd:COG0525 584 LMNLEGFDPGLDPDP--------------EELSLADRWILSrLNKTIAE-VTEALEKYRFDEAAQALYDFVwNEFCDWYL 648
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 752 RLNRRRIKGELGADQcIQSLDTLYDVLYTMVKMMAPFTPYLTEYIFQRLVLFQPAGTLEHADsvhyqmMPVSQKKFIRND 831
Cdd:COG0525 649 ELAKPRLYGGDEAAK-RETRATLVYVLEQILRLLHPFMPFITEEIWQKLPPRKEGESIMLAP------WPEADEELIDEE 721
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24668547 832 IERSVALMQSVVELGRVMRDRRTLPVKYPVsEIIAIHKDSQILEAIKTLQDFILSELNVRKLTLSSDKE 900
Cdd:COG0525 722 AEAEFEWLKEVISAIRNIRAEMNIPPSKKL-PLLLKGADEADRARLEENAAYIKRLARLEEITILVDEK 789
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
409-640 |
2.35e-48 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 177.44 E-value: 2.35e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 409 CWRSDTPLIYKAVPSWFVRVEHMSKNLLDCSSQTY--WVPDFVkEKRFGNWLKEARDWAISRNRYWGTPIPIWRSPSGDE 486
Cdd:cd00817 156 CSRSGDVIEPLLKPQWFVKVKDLAKKALEAVKEGDikFVPERM-EKRYENWLENIRDWCISRQLWWGHRIPAWYCKDGGH 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 487 tVVIGSIKQLAelsgvqvedlhresIDHIEIPSAVPGNPP-LRRIAPVFDCWFESGSMPFAQQHFPfENEKDFMNNFPAD 565
Cdd:cd00817 235 -WVVAREEDEA--------------IDKAAPEACVPCGGEeLKQDEDVLDTWFSSSLWPFSTLGWP-EETKDLKKFYPTS 298
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24668547 566 FIAEGIDQTRGW-FYTLLvISTALFNKAPFKNLIASGLVLAADGQKMSKRKKNYPDPMEVVHKYGADALRLYLINS 640
Cdd:cd00817 299 LLVTGHDIIFFWvARMIM-RGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDGYGADALRFTLASA 373
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
416-638 |
8.49e-44 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 161.82 E-value: 8.49e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 416 LIYK------AVPSWFVRVEHMSKNLLDCSSQTYWVPDFVKeKRFGNWLKEARDWAISRNRYWGTPIPIWrspsgdetvv 489
Cdd:cd00668 128 LIYRgthpvrITEQWFFDMPKFKEKLLKALRRGKIVPEHVK-NRMEAWLESLLDWAISRQRYWGTPLPED---------- 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 490 igsikqlaelsgvqvedlhresidhieipsavpgnpplrriapVFDCWFESGSMPFAQQHFPFENEkDFMNNFPADFIAE 569
Cdd:cd00668 197 -------------------------------------------VFDVWFDSGIGPLGSLGYPEEKE-WFKDSYPADWHLI 232
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24668547 570 GIDQTRGWFYTLLVISTALFNKAPFKNLIASGLVLAADGQKMSKRKKNYPDPMEVVHKYGADALRLYLI 638
Cdd:cd00668 233 GKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVEKYGADALRYYLT 301
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
8-800 |
1.19e-42 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 169.74 E-value: 1.19e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 8 NDVCRVPE---NINFpAEEENVLQKWRHENIFEkcSQLSKGKPKYTFYDGPPFATGLPHYGHILAGTIKDIVTRYAYQQG 84
Cdd:PLN02943 49 NDVFTSPEtakSFDF-TSEERIYNWWESQGYFK--PNFDRGGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKG 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 85 YHVDRRFGWDCHGLPVEFEIDKLLNIKGPEDVaKMGIAAYNAECRKIVMRYADEWENVVTRVGRWIDFKNDYKTLYPWYM 164
Cdd:PLN02943 126 RPTLWIPGTDHAGIATQLVVEKMLASEGIKRT-DLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLS 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 165 ESIWWIFKQLFDKGLVYQGVKVMPYSTACTTSLSNFEANqnYKEVVDPCVVVALEAVSLPNTFFLVWTTTPWTLPSNFAC 244
Cdd:PLN02943 205 RAVVEAFVRLHEKGLIYQGSYMVNWSPNLQTAVSDLEVE--YSEEPGTLYYIKYRVAGGSEDFLTIATTRPETLFGDVAI 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 245 CVHPtmtyvkvrdvKSDRLfvlaesrlsyvykseteyevkEKFVGKTlkdlhykPLFPYFAKRGAEVKAyrvlvDEYVTE 324
Cdd:PLN02943 283 AVNP----------EDDRY---------------------SKYIGKM-------AIVPMTYGRHVPIIA-----DRYVDK 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 325 DSGTGIVHNAPYFGEDDYRVCLAAGLitkssEVLCPVDEAGRFTNEAsdfeGQYVKDSDKQIMAALKARGNLVSSGQVKH 404
Cdd:PLN02943 320 DFGTGVLKISPGHDHNDYLLARKLGL-----PILNVMNKDGTLNEVA----GLYWFEAREKLWSDLEETGLAVKKEPHTL 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 405 SYPFCWRSDT---PLIYKavpSWFVRVEHMSKNLLDC--SSQTYWVPDFVkEKRFGNWLKEARDWAISRNRYWGTPIPIW 479
Cdd:PLN02943 391 RVPRSQRGGEviePLVSK---QWFVTMEPLAEKALKAveNGELTIIPERF-EKIYNHWLSNIKDWCISRQLWWGHRIPVW 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 480 RSPSGD-ETVVIgsIKQLAELSGVQVEDLHRESIDHIEIPSavpgnpplrriapVFDCWFESGSMPFAQQHFPFENEKDF 558
Cdd:PLN02943 467 YIVGKDcEEDYI--VARSAEEALEKAREKYGKDVEIYQDPD-------------VLDTWFSSALWPFSTLGWPDVSAEDF 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 559 MNNFPADFIAEGIDQTRGWFYTLLVISTALFNKAPFKNLIASGLVLAADGQKMSKRKKNYPDPMEVVHKYGADALRLYLi 638
Cdd:PLN02943 532 KKFYPTTVLETGHDILFFWVARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIKEFGTDALRFTL- 610
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 639 nSPVVRAESLRFKEEgvRDIIKDVFL-PWYNAYRFLLQNIVryEKEDLAGngqytYDRERHLKNMDKASVI-----DVWI 712
Cdd:PLN02943 611 -ALGTAGQDLNLSTE--RLTSNKAFTnKLWNAGKFVLQNLP--SQSDTSA-----WEHILACKFDKEESLLslplpECWV 680
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 713 LSFKESLLEFFATEMKMYrLYTVVPRLTK--FIDQLTNWYVRLNRRRIKGELGADQCIQSLDTLYDVLYTMVKMMAPFTP 790
Cdd:PLN02943 681 VSKLHELIDSVTTSYDKY-FFGDVGREIYdfFWSDFADWYIEASKTRLYHSGDNSALSRAQAVLLYVFENILKLLHPFMP 759
|
810
....*....|
gi 24668547 791 YLTEYIFQRL 800
Cdd:PLN02943 760 FVTEELWQAL 769
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
30-903 |
2.79e-42 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 168.65 E-value: 2.79e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 30 WRHENIFEKCSQLS--KGKPKYTFYDGPPFATGLPHYGHILAGTIKDIVTRYAYQQGYHVDRRFGWDCHGLP----VEFE 103
Cdd:PTZ00419 41 WEKSGFFKPAEDAKslNSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDHAGIAtqvvVEKK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 104 IDKLLNIK----GPEDVAKMgiaaynaecrkiVMRYADEWENVVT----RVGRWIDFKNDYKTLYPWYMESIWWIFKQLF 175
Cdd:PTZ00419 121 LMKEENKTrhdlGREEFLKK------------VWEWKDKHGNNICnqlrRLGSSLDWSREVFTMDEQRSKAVKEAFVRLY 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 176 DKGLVYQGVKVMPYSTACTTSLSNFEANqnYKEVVDPCVV----------------VALEAVSLPNTFFLVWTTTPWTLP 239
Cdd:PTZ00419 189 EDGLIYRDTRLVNWCCYLKTAISDIEVE--FEEIEKPTKItipgydkkvevgvlwhFAYPLEDSGQEEIVVATTRIETML 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 240 SNFACCVHPtmtyvkvrdvKSDRlfvlaesrlsyvYKseteyevkeKFVGKTLKdlHykplfPYFAKRGAEVkayrVLVD 319
Cdd:PTZ00419 267 GDVAVAVHP----------KDER------------YK---------KLHGKELI--H-----PFIPDRKIPI----IADD 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 320 EYVTEDSGTGIVHNAPYFGEDDYRVCLAAGLitkssEVLCPVDEAGRFTNEASDFEGQYVKDSDKQIMAALKARGNLVss 399
Cdd:PTZ00419 305 ELVDMEFGTGAVKITPAHDPNDYEIAKRHNL-----PFINIFTLDGKINENGGEFAGMHRFDCRRKIEEELKEMGLLR-- 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 400 GQVKHSY--PFCWRSDTPLIYKAVPSWFVRVEHMSKNLLDC--SSQTYWVPDFvKEKRFGNWLKEARDWAISRNRYWGTP 475
Cdd:PTZ00419 378 DKVPNPMrlPRCSRSGDIVEPMLIPQWYVNCKDMAKRAVEAvrNGELKIIPSS-HENVWYHWLENIQDWCISRQLWWGHR 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 476 IPIWR--------SPSGDETVVIG-----SIKQLAELSGVQVEDLHresidhieipsavpgnppLRRIAPVFDCWFESGS 542
Cdd:PTZ00419 457 IPAYRviskgpetDPSDEEPWVVArseeeALEKAKKKFGLSEEDFE------------------LEQDEDVLDTWFSSGL 518
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 543 MPFAQQHFPFENEkDFMNNFPADFIAEGIDQTRGWFYTLLVISTALFNKAPFKNLIASGLVLAADGQKMSKRKKNYPDPM 622
Cdd:PTZ00419 519 FPFSTLGWPDQTD-DLQRFFPTSLLETGSDILFFWVARMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPL 597
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 623 EVVHKYGADAL--RLYLINSP---VVRAESLRFKE--EGV-------------------RDIIKDV--------FLP--W 666
Cdd:PTZ00419 598 EVIEGISLQDLnqKLYEGNLPekeIKRAIELQKKEfpNGIpecgtdalrfgllaytqqgRNINLDInrvvgyrhFCNklW 677
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 667 yNAYRFLLQNIvryekEDLAGNGQYTYDrerHLKNMDKASVIDVWILSFKESLLEFFATEMKMYRLYTVVPRLTKF-IDQ 745
Cdd:PTZ00419 678 -NAVKFALMKL-----LKDFNLPNSTLF---KPNNVESLPWEDKWILHRLNVAIKEVTEGFKEYDFSEATQATYNFwLYE 748
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 746 LTNWYVRLNRRRIKGELGADQCIQSLDTLYDVLYTMVKMMAPFTPYLTEYIFQRLvlfqpAGTLEHADSVHYQMMPVSQK 825
Cdd:PTZ00419 749 LCDVYLELIKPRLSKQSDGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELYQRL-----PNYLRKSESISIAKYPQPNP 823
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 826 KFIRNDIERSVALMQSVVELGRVMRDRRTLPVKYPVSEIIAIHKDSQIlEAIKTLQDFI-----LSELNVRKLTLSSDKE 900
Cdd:PTZ00419 824 GWNNEALDEEMKIIMSIVKSIRSLIATLGIPNKTKPDCYVTAKDAELI-ELIESAENLIstlakIGSVSVIPPIEEEAEV 902
|
...
gi 24668547 901 KYG 903
Cdd:PTZ00419 903 PKG 905
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
48-186 |
7.39e-33 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 130.23 E-value: 7.39e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 48 KYTFYDGPPFATGLPHYGHILAGTIKDIVTRYAYQQGYHVDRRFGWDCHGLPVEFEIDKLLNIKGPEDVakmgIAAYNAE 127
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKKTIW----IEEFRED 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 24668547 128 CRKIVMRYADEWENVVTRVGRWIDFKNDYKTLYPWYMESIWWIFKQLFDKGLVYQGVKV 186
Cdd:cd00668 77 PKEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHP 135
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
18-800 |
2.93e-29 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 126.40 E-value: 2.93e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 18 NFPAEEENVLQKWRHENIFEkcSQLSKGKPKYTFYDGPPFATGLPHYGHILAGTIKDIVTRYAYQQGYHVDRRFGWDCHG 97
Cdd:TIGR00396 2 NHIEIEEKWQQKWDENKTFK--VTDDSSKPKYYILSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 98 LPVE-FEIDkllNIKGPEDVAKMGIAAYNAEcrkivmryadewenvVTRVGRWIDFKNDYKTLYPWYMESIWWIFKQLFD 176
Cdd:TIGR00396 80 LPAEnAAIK---RGIHPAKWTYENIANMKKQ---------------LQALGFSYDWDREIATCDPEYYKWTQWIFLELFE 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 177 KGLVYqgVKVMP--YSTACTTSLSNFEANQNYK-------------------------------EVVD--PCVV------ 215
Cdd:TIGR00396 142 KGLAY--VKEADvnWCPNDGTVLANEQVDSDGRswrgdtpvekkelkqwflkitayaeellndlEELDhwPESVkemqrn 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 216 -------VALE-AVSLPNTFFLVWTTTPWTLpsnFACcvhptmTYVkvrdvksdrlfVLA-ESRLSYVYkSETEYEVKEk 286
Cdd:TIGR00396 220 wigksegVEITfKIADHDEKITVFTTRPDTI---FGV------TYL-----------ALApEHPLVEKA-AENNPKVAA- 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 287 FVGK------TLKDLHYKPlfpyfaKRGAEVKAYR----------VLVDEYVTEDSGTGIVHNAPYFGEDDYRVCLAAGL 350
Cdd:TIGR00396 278 FIKKilnktvAERTKATKE------KKGVDTGIKAihpltgekipIWVANYVLMEYGTGAVMGVPAHDERDFEFAQKYGL 351
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 351 ITKssEVLCPvdeagrftneasdfegqyvKDSDKQIMAALKARGNLVSSGQvkHSypfcwRSDTPLIYKAVPSWFVrveh 430
Cdd:TIGR00396 352 PIK--PVIDP-------------------AEKDLSLTAAYTEDGVLVNSGE--FN-----GLNSSEARNAIIDMLE---- 399
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 431 msKNLLDCSSQTYwvpdfvkekrfgnwlkEARDWAISRNRYWGTPIPIWRSPSGDETVVIGS-----IKQLAELSGVQVE 505
Cdd:TIGR00396 400 --KEGKGKRKVNY----------------RLRDWGFSRQRYWGEPIPIIHCEDGGVVPVPEEdlpviLPEDVVYDGDGGS 461
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 506 DLHRESiDHIEIPSAVPGNPPLRR--IAPVF--DCWFESGSMPFAQQHFPFENEKdFMNNFPADFIAEGIDQT------- 574
Cdd:TIGR00396 462 PLSRIP-EWVNVTCPSCGKPALREtdTMDTFagSSWYYLRYLDPKNTDGPFDKEK-AEYWLPVDLYIGGIEHAilhllya 539
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 575 RGW---FYTLLVISTalfnKAPFKNLIASGLVLA-------------------------------ADGQKMSKRKKNYPD 620
Cdd:TIGR00396 540 RFFhkfLRDIGYVNT----KEPFKKLINQGMVLGfyyppngkvpadvlterdekgkdkaggelvyVGYEKMSKSKGNGID 615
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 621 PMEVVHKYGADALRLYLI-NSPVvrAESLRFKEEGVRdiikdvflpwyNAYRFlLQNIVRYEKEDLaGNGQYTYDRERHL 699
Cdd:TIGR00396 616 PQEIVESYGADALRLFIMfMGPI--AASLEWNESGLE-----------GARRF-LDRVWNLVYEIT-GELDAASLTVTAL 680
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 700 KNMDKASVIDVwilsfKESLLEFFATEMKMYRLYTVVPRLTKFIDQLTNwyvrlnrrrikgelgadqciQSLDTLY-DVL 778
Cdd:TIGR00396 681 EEAQKELRRDV-----HKFLKKVTEDLEKRESFNTAISAMMELLNKLYK--------------------AKKEALMlEYL 735
|
890 900
....*....|....*....|..
gi 24668547 779 YTMVKMMAPFTPYLTEYIFQRL 800
Cdd:TIGR00396 736 KGFVTVLSPFAPHLAEELWEKL 757
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
46-955 |
3.62e-24 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 110.37 E-value: 3.62e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 46 KPKYTFYDGPPFATGLPHYGHILAGTIKDIVTRYAYQQGYHVDRRFGWDCHGLPVEFEIDKLLNIKGPEDVAKMGIAAYN 125
Cdd:PLN02381 127 KPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGIATQVVVEKKLMRERHLTRHDIGREEFV 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 126 AECRKIVMRYADEWENVVTRVGRWIDFKNDYKTLYPWYMESIWWIFKQLFDKGLVYQGVKVMPYSTACTTSLSNFEANQ- 204
Cdd:PLN02381 207 SEVWKWKDEYGGTILNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRLYKEGLIYRDIRLVNWDCTLRTAISDVEVDYi 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 205 -----------NYKEVVDPCVVVALeAVSLPNTF--FLVWTTTPWTLPSNFACCVHPtmtyvkvrdvksdrlfvlaesrl 271
Cdd:PLN02381 287 dikertllkvpGYDKPVEFGVLTSF-AYPLEGGLgeIVVATTRIETMLGDTAIAIHP----------------------- 342
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 272 syvykseteyevkekfvgktlKDLHYKPLFPYFAKRGAEVKAYRVLVD-EYVTEDSGTGIVHNAPYFGEDDYRVCLAAGL 350
Cdd:PLN02381 343 ---------------------DDERYKHLHGKFAVHPFNGRKLPIICDaILVDPNFGTGAVKITPAHDPNDFEVGKRHNL 401
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 351 itkssEVLCPVDEAGRF-TNEASDFEGQYVKDSDKQIMAALKARGNLVSSGQVKHSYPFCWRSD---TPLIYkavPSWFV 426
Cdd:PLN02381 402 -----EFINIFTDDGKInSNGGSEFAGMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNdvvEPMIK---PQWFV 473
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 427 RVEHMSKNLLDC-----SSQTYWVP-DFVKEKRfgNWLKEARDWAISRNRYWGTPIPIWRSPSGDEtvvigSIKQLAELS 500
Cdd:PLN02381 474 NCSSMAKQALDAaidgeNKKLEFIPkQYLAEWK--RWLENIRDWCISRQLWWGHRIPAWYVTLEDD-----QLKELGSYN 546
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 501 GVQVEDlHRESIDHIEIPSAVPGNP-PLRRIAPVFDCWFESGSMPFAQQHFPfENEKDFMNNFPADFIAEGIDQTRGWFY 579
Cdd:PLN02381 547 DHWVVA-RNESDALLEASQKFPGKKfELSQDPDVLDTWFSSGLFPLSVLGWP-DDTDDLKAFYPTSVLETGHDILFFWVA 624
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 580 TLLVISTALFNKAPFKNLIASGLVLAADGQKMSKRKKNYPDPMEVV--------HKY----------------------- 628
Cdd:PLN02381 625 RMVMMGMQLGGDVPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVIngisleglHKRleegnldpkelvvakegqkkdfp 704
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 629 ------GADALRLYLINspvVRAESLRFKeegvRDIIKDV-FLPWYNAyrflLQNIVRYEKEDLaGNGqYTYDRERHLKN 701
Cdd:PLN02381 705 ngiaecGTDALRFALVS---YTAQSDKIN----LDILRVVgYRQWCNK----LWNAVRFAMSKL-GDD-YTPPATLSVET 771
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 702 MdkaSVIDVWILSFKESLLEFFATEMKMYRLYTVVPRLTK---------FIDQLTNWYVRLNrRRIKGELGADQciqslD 772
Cdd:PLN02381 772 M---PFSCKWILSVLNKAISKTVSSLDAYEFSDAASTVYSwwqyqfcdvFIEAIKPYFAGDN-PEFASERAAAQ-----D 842
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 773 TLYDVLYTMVKMMAPFTPYLTEYIFQRLVlfQPAGTlEHADSVHYQMMPVSQKKFIRNDIERSVALMQSVVELGRVMRDR 852
Cdd:PLN02381 843 TLWICLDTGLRLLHPFMPFVTEELWQRLP--QPKDH-TRKDSIMISEYPSAVEAWTNEKVEYEMDLVLSTVKCLRSLRAE 919
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 853 RTLPVKYPVSEIIAIHKDSQILEAIKTLQDFILSELNVRKL-TLSSDKEKYGVTLRAEPDHKALGQRLKGNFKA-VMAAI 930
Cdd:PLN02381 920 VLEKQKNERLPAFALCRNQEIAAIIKSHQLEILTLANLSSLkVLLSENDAPPAGCAFENVNENLKVYLQAQGAVnAEAEL 999
|
970 980
....*....|....*....|....*..
gi 24668547 931 KALRD--DEIQKQvsqgyFDILDQRIE 955
Cdd:PLN02381 1000 EKLRNkmDEIQKQ-----QEKLEKKMN 1021
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
62-844 |
1.32e-23 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 108.03 E-value: 1.32e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 62 PHYGHILAGTIKDIVTRYAYQQGYHVDRRFGWDCHGLPV-----------EFEIDKLLNIKG-PEDV-AKMGiaaynaEC 128
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPIlgiaeriargdPETIELYKSLYGiPEEElEKFK------DP 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 129 RKIVMRYADEWENVVTRVGRWIDFKNDYKTLYPWYMESIWWIFKQLFDKGLVYQGVKVMPYSTACTT------------- 195
Cdd:PRK12300 75 EYIVEYFSEEAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNpvgdhdlldgeep 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 196 -----SLSNFEanqNYKEVVDPCvvvaleAVSLPNTFFLVwtTTPWtlpsnfaccVHPTMTYVKVRdVKSDRLFVlaeSR 270
Cdd:PRK12300 155 eiveyTLIKFE---ESEDLILPA------ATLRPETIFGV--TNLW---------VNPDATYVKAE-VDGEKWIV---SK 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 271 LSYVYKSETEYEVK-------EKFVGKTLKDlhykPLfpyfakRGAEVKayrVLVDEYVTEDSGTGIV-----HnAPYfg 338
Cdd:PRK12300 211 EAAEKLSFQDRDVEiieeikgSELIGKKVKN----PV------TGKEVP---ILPADFVDPDNGTGVVmsvpaH-APY-- 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 339 edDYrvclaAGL--ITKSSEVLCPV---------------------------------DEA-----------GRFTNEAS 372
Cdd:PRK12300 275 --DY-----VALrdLKKNKELLDVIepiplievegygefpakevveklgiksqedpelEEAtkevyraefhkGVLKENTG 347
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 373 DFEGQYVKDSDKQIMAALKARGNL-----VSSGQVkhsypFCwRSDTPLIYKAVP-SWFVR--VEHMSKNLLDCSSQTYW 444
Cdd:PRK12300 348 EYAGKPVREAREKITKDLIEKGIAdimyeFSNRPV-----YC-RCGTECVVKVVKdQWFIDysDPEWKELAHKALDNMEI 421
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 445 VPDFVKeKRFGN---WLKearDWAISRNRYWGTPIPiWrspsgDETVVIGS-------------IKQLAELsGVQVEDLH 508
Cdd:PRK12300 422 IPEEYR-KEFENtidWLK---DRACARRRGLGTRLP-W-----DEEWIIESlsdstiymayytiAHKIREY-GIKPEQLT 490
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 509 RESIDHI-------EIPSAVPGNPP--LRRIAPVFDCWFesgsmPFAQQHfpfeNEKDFMNNFPADFIaegidqtrgwFY 579
Cdd:PRK12300 491 PEFFDYVflgkgdpEEVSKKTGIPKeiLEEMREEFLYWY-----PVDWRH----SGKDLIPNHLTFFI----------FN 551
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 580 tllviSTALF--NKAPfKNLIASGLVLAaDGQKMSKRKKNYPDPMEVVHKYGADALRLYLINSpvvrAE---SLRFKEEG 654
Cdd:PRK12300 552 -----HVAIFpeEKWP-RGIVVNGFVLL-EGKKMSKSKGNVIPLRKAIEEYGADVVRLYLTSS----AEllqDADWREKE 620
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 655 VRDIIKDVflpwynaYRFLlqnivryekeDLAGNGqYTYDRERHLKnmdkasVIDVWILSFKESLLEFFATEMKMYRLYT 734
Cdd:PRK12300 621 VESVRRQL-------ERFY----------ELAKEL-IEIGGEEELR------FIDKWLLSRLNRIIKETTEAMESFQTRD 676
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 735 VVPRLTKFIDQLTNWYvrlnRRRIKGELGadqciqslDTLYDVLYTMVKMMAPFTPYLTEYIFQRlvlfqpagtLEHADS 814
Cdd:PRK12300 677 AVQEAFYELLNDLRWY----LRRVGEANN--------KVLREVLEIWIRLLAPFTPHLAEELWHK---------LGGEGF 735
|
890 900 910
....*....|....*....|....*....|
gi 24668547 815 VHYQMMPVSQKKFIRNDIERSVALMQSVVE 844
Cdd:PRK12300 736 VSLEKWPEPDESKIDEEAELAEEYVKRLIE 765
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
709-865 |
4.78e-21 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 90.54 E-value: 4.78e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 709 DVWILSFKESLLEFFATEMKMYRLYTVVPRLTKFI-DQLTNWYVRLNRRRIKGELGADQCIQsldTLYDVLYTMVKMMAP 787
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFwNDLSDWYLELIKDRLYGEEPDSRAQT---TLYEVLETLLRLLAP 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24668547 788 FTPYLTEYIFQRlvlfqpagtlehaDSVHYQMMPVSqKKFIRNDIERSVALMQSVVELGRVMRDRRTLPVKYPVSEII 865
Cdd:pfam08264 78 FMPFITEELWQK-------------ESIHLAPWPED-AELEEAELEEAFELRQEIVQAIRKLRSELKIKKSLPLEVVI 141
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
30-831 |
2.51e-20 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 97.59 E-value: 2.51e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 30 WRHENIFEKCSQLSKGKPKYTFYDGPPFATGLP-HYGHILAGTIKDIVTRYAYQQGYHVDRRFGWDCHGLPVE-FEIDKL 107
Cdd:PLN02563 93 WEENRTFRTPDDVDTSKPKFYVLDMFPYPSGAGlHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLPAEqYAIETG 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 108 LNikgPEDVAKMGIAAYNAECRKIVMRYadEWENVVTrvgrwidfkndykTLYPWYMESIWWIFKQLFDKGLVYQGVKVM 187
Cdd:PLN02563 173 TH---PKITTLKNIARFRSQLKSLGFSY--DWDREIS-------------TTEPEYYKWTQWIFLQLLKRGLAYQAEVPV 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 188 PYSTACTTSLSNfeanqnyKEVVD--------PCVVVALEAVSLPNTFF----------LVWTTTPWTLPSNF------- 242
Cdd:PLN02563 235 NWCPALGTVLAN-------EEVVDglsergghPVIRKPMRQWMLKITAYadrlledlddLDWPESIKEMQRNWigrsega 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 243 --ACCV-----HPTMTYVKVRDVKSDRLF-----VLA--ESRLSYVYKSETEYEVKEkFVGKTLK--DLHYKPL------ 300
Cdd:PLN02563 308 elDFSVldgegKERDEKITVYTTRPDTLFgatylVVApeHPLLSSLTTAEQKEAVEE-YVDAASRksDLERTELqkektg 386
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 301 -FP-YFAKRGAEVKAYRVLVDEYVTEDSGTGIVHNAPYFGEDDYRVCLAAGLITK---------SSEVLCPVDEAGRFTN 369
Cdd:PLN02563 387 vFTgSYAINPATGEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKwvvkpadgnEDDAEKAYTGEGVIVN 466
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 370 EAS---DFEGQYVKDSDKQIMAALKARGNlvssGQVKHSYPFcwrsdtpliykavpswfvrvehmsknlldcssqtywvp 446
Cdd:PLN02563 467 SSSsglDINGLSSKEAAKKVIEWLEETGN----GKKKVNYKL-------------------------------------- 504
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 447 dfvkekrfgnwlkeaRDWAISRNRYWGTPIPIWRSPSGDETVVIGSikqlAELSgVQVEDLHRESidhieiPSAVPgNPP 526
Cdd:PLN02563 505 ---------------RDWLFARQRYWGEPIPVVFLEDSGEPVPVPE----SDLP-LTLPELDDFT------PTGTG-EPP 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 527 LRRIA-------PVFDCWF--ESGSMP----------------FAQQHFPFENEKDFMnnfPADFIAEGIDQ-------T 574
Cdd:PLN02563 558 LAKAVswvntvdPSSGKPArrETNTMPqwagscwyylrfmdpkNSNALVDKEKEKYWM---PVDLYVGGAEHavlhllyA 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 575 RGW---FYTLLVISTalfnKAPFKNLIASGLVLA---------ADGQ--------------------------------- 609
Cdd:PLN02563 635 RFWhkvLYDIGVVST----KEPFQCLVNQGMILGeveytafkdSDGEyvsadtadrlgelqqekipeekviksgdsfvlk 710
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 610 ------------KMSKRKKNYPDPMEVVHKYGADALRLYLINSPVVRAeSLRFKEEGVRDIIKdvFLPwyNAYRFLL--- 674
Cdd:PLN02563 711 ddpsirliarahKMSKSRGNVVNPDDVVSEYGADSLRLYEMFMGPLRD-SKTWSTSGVEGVHR--FLG--RTWRLVVgap 785
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 675 QNIVRYEKEDLAGNGQYTYDRERHL-KNMDKASvidvwilsfkeslleffaTEMKMYRLYTVVPRLTKFIDQLTNWYvrl 753
Cdd:PLN02563 786 LPDGSFRDGTVVTDEEPSLEQLRLLhKCIAKVT------------------EEIESTRFNTAISAMMEFTNAAYKWD--- 844
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24668547 754 NRRRikgelgadQCIQSLdtlydvlytmVKMMAPFTPYLTEYIFQRlvlfqpagtLEHADSVHYQMMPVSQKKFIRND 831
Cdd:PLN02563 845 KVPR--------EAIEPF----------VLLLSPYAPHLAEELWFR---------LGHSNSLAYEPWPEANPSYLVDD 895
|
|
| DUF5915 |
pfam19302 |
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of ... |
881-1042 |
7.00e-20 |
|
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of isoleucyl tRNA ligase enzymes.
Pssm-ID: 437134 [Multi-domain] Cd Length: 195 Bit Score: 89.07 E-value: 7.00e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 881 QDFILSELNVRKLTLSSDKEKYgVTLRAEPDHKALGQRLKGNFKAVMAAIKALRDDEIQKQVSQG--YFDILDQRIELDE 958
Cdd:pfam19302 1 EDIIKEELNVKEVEFGADESEL-VEYSAKPNFPVLGKELGKLMKAAAKEIASLNQMEIQKILDGGtlTIDVDGEEIELTS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 959 VRIIyCTSEQVGGnFEAHSDNEVLVLLDMTPNEELLEEGLAREVINRVQKLKKKAQLIPTDPVLIFhelAADNKAKQEVL 1038
Cdd:pfam19302 80 EDLL-VTRQGKEG-LAVANEGTLTVALDTTITEELREEGLVREIVSKIQNLRKESGFEVTDRINLY---VSGNEMLEAAI 154
|
....
gi 24668547 1039 EAQA 1042
Cdd:pfam19302 155 EKFE 158
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
462-867 |
1.06e-18 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 92.04 E-value: 1.06e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 462 RDWAISRNRYWGTPIPIWRSPSGDETVVigSIKQL-AELSgvqvEDlhresidhiEIPSAVPGNP--------------- 525
Cdd:COG0495 420 RDWLISRQRYWGEPIPIIHCEDCGVVPV--PEDQLpVELP----ED---------VDFDPTGGSPlarapewvnvtcpkc 484
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 526 --PLRRIAPVFDCWFES------------GSMPFAQqhfpfENEKDFMNnfpadfiaegIDQ--------------TRgw 577
Cdd:COG0495 485 ggPARRETDTMDTFVDSswyylrytdphnDEAPFDP-----EAANYWLP----------VDQyiggiehailhllyAR-- 547
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 578 FYT-LL----VISTalfnKAPFKNLIASGLV--LAADG------QKMSKRKKNYPDPMEVVHKYGADALRLYLI-NSPVV 643
Cdd:COG0495 548 FFTkVLrdlgLVSF----DEPFKRLLTQGMVleVGKDGvviggiEKMSKSKGNVVDPDEIIEKYGADTLRLFEMfAGPPE 623
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 644 RaeSLRFKEEGVRdiikdvflpwyNAYRFL---------LQNIVRYEKEDLAGNGQYTYdRERHlKNMDKASvidvwils 714
Cdd:COG0495 624 R--DLEWSDSGVE-----------GAYRFLnrvwrlvvdEAEALKLDVADLSEADKELR-RALH-KTIKKVT-------- 680
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 715 fkeslleffaTEMKMYRLYTVVPRLTKFIDQLTnwyvrlnrrRIKGELGADQCIqsldtLYDVLYTMVKMMAPFTPYLTE 794
Cdd:COG0495 681 ----------EDIERLRFNTAIAALMELVNALY---------KAKDSGEADRAV-----LREALETLVLLLAPFAPHIAE 736
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24668547 795 YIFQRlvlfqpagtLEHADSVHYQMMPVSQKKfirndiersvALMQSVVEL-----GRVmRDRRTLPVKYPVSEIIAI 867
Cdd:COG0495 737 ELWER---------LGHEGSVADAPWPEADEA----------ALVEDEVTIvvqvnGKV-RGKIEVPADASKEELEAA 794
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
56-183 |
1.17e-13 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 73.44 E-value: 1.17e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 56 PFATGLPHYGHILAGTIKDIVTRYAYQQGYHVDRRFGWDCHGLPVEFEIDKllNIKGPEDVAKmgiaaYNAEcrkivmry 135
Cdd:cd00812 9 PYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIK--IGRDPEDWTE-----YNIK-------- 73
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 24668547 136 adEWENVVTRVGRWIDFKNDYKTLYPWYMESIWWIFKQLFDKGLVYQG 183
Cdd:cd00812 74 --KMKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKK 119
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
667-800 |
2.10e-13 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 68.35 E-value: 2.10e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 667 YNAYRFLLQNIVRYEKEDlagngqytydrerhlKNMDKASVIDVWILSFKESLLEFFATEMKMYRLYTVVPRLTKFI-DQ 745
Cdd:cd07962 17 WNAARFVLMNLEDDDEPE---------------EDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFwND 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 24668547 746 LTNWYVRLNRRRIKGElGADQCIQSLDTLYDVLYTMVKMMAPFTPYLTEYIFQRL 800
Cdd:cd07962 82 FCDWYLELVKPRLYGE-DEEEKKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
424-638 |
1.07e-10 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 64.58 E-value: 1.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 424 WFVRVEHMS--KNLLDCSSQTYWVPDFVKeKRFGNWLkeardwAISRNRYWGTPIPIwrspsGD--ETVVIGSIKQLAEL 499
Cdd:cd00812 132 WFLKYSETEwkEKLLKDLEKLDGWPEEVR-AMQENWI------GCSRQRYWGTPIPW-----TDtmESLSDSTWYYARYT 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 500 sgvqveDLHRESIDHIEIPSavpgnpplrriapvfdcwfesgsmpfaqqhfpfENEKDFMNNFPADFIAEGIDQTRGWFY 579
Cdd:cd00812 200 ------DAHNLEQPYEGDLE---------------------------------FDREEFEYWYPVDIYIGGKEHAPNHLL 240
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24668547 580 TLLVISTALFNKA-----PFKNLIASGLVLAaDGQKMSKRKKNYPDPMEVVHKYGADALRLYLI 638
Cdd:cd00812 241 YSRFNHKALFDEGlvtdePPKGLIVQGMVLL-EGEKMSKSKGNVVTPDEAIKKYGADAARLYIL 303
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
671-821 |
4.71e-10 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 59.85 E-value: 4.71e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 671 RFLLQNIvryekedlagngqYTYDRERHLKNMDKASVIDVWILS----FKESLLEFFATemkmYRLYTVVPRLTKFI-DQ 745
Cdd:cd07960 21 RFLLGNL-------------NDFDPAKDAVPYEELLELDRYALHrlneLIKEVREAYEN----YEFHKVYQALNNFCtVD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 746 LTNWYV-----RL-------NRRRikgelgadqCIQSldTLYDVLYTMVKMMAPFTPYLTEYIFQrlvlFQPAGTLEhaD 813
Cdd:cd07960 84 LSAFYLdiikdRLycdakdsLERR---------SAQT--VLYHILDALLKLLAPILPFTAEEVWE----HLPGEKKE--E 146
|
....*...
gi 24668547 814 SVHYQMMP 821
Cdd:cd07960 147 SVFLEDWP 154
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
342-638 |
1.64e-09 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 62.05 E-value: 1.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 342 YRVCLAAGLI-TKSSEVL-CPVDEagRFTNEAsdfegqYVK------DSDKQIMAALKARGNLVSSGQVKHsyPFCWRSD 413
Cdd:COG0143 106 FQRLYDNGDIyKGEYEGWyCPECE--RFLPDR------YVEgtcpkcGAEDAYGDQCENCGATLEPTELIN--PRSAISG 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 414 TPLIYKAVPSWFVRVEHMSKNLLD-CSSQTYWVPDFVKEKRfgNWLKEA-RDWAISRNRYWGTPIPiwrspsGDEtvvig 491
Cdd:COG0143 176 APPELREEEHYFFRLSKYQDRLLEwIEENPDIQPEVRNEVL--SWLKEGlQDLSISRDFDWGIPVP------GDP----- 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 492 sikqlaelsgvqvedlhresiDHieipsavpgnpplrriapVFDCWFE------SGSMPFAQQHFPFENEKDFMNNFPAD 565
Cdd:COG0143 243 ---------------------GK------------------VFYVWFDaligyiSATKGYADDRGLPEDFEKYWPAPDTE 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 566 ---FIaeGIDQTRgwFYTllVISTALfnkapfknLIASGLVLAA----------DGQKMSKRKKNYPDPMEVVHKYGADA 632
Cdd:COG0143 284 lvhFI--GKDIIR--FHA--IIWPAM--------LMAAGLPLPKkvfahgfltvEGEKMSKSRGNVIDPDDLLDRYGPDA 349
|
....*.
gi 24668547 633 LRLYLI 638
Cdd:COG0143 350 LRYYLL 355
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
342-641 |
5.29e-08 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 56.53 E-value: 5.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 342 YRVCLAAGLI-TKSSEVL-CPVDEagRFTNEAsdfegqYVKDSDKQIMAAlKAR-------GNLVSSGQVKHsyPFCWRS 412
Cdd:pfam09334 104 FLKLYENGYIyEKEIEQFyCPSDE--RFLPDR------YVEGTCPHCGSE-DARgdqcencGRHLEPTELIN--PKCVIC 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 413 DTPLIYKAVPSWFVRVEHMSKNLLD--CSSQTYWVPDFVKEKRfgNWLKEA-RDWAISRNRYWGTPIPiwrspsGDEtvv 489
Cdd:pfam09334 173 GTTPEVKETEHYFFDLSKFQDKLREwiEENNPEWPENVKNMVL--EWLKEGlKDRAISRDLDWGIPVP------GAE--- 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 490 igsikqlaelsgvqvedlhresiDHieipsavpgnpplrriapVFDCWFES--GSMPFAQQhfPFENEKDFMNNFPAD-- 565
Cdd:pfam09334 242 -----------------------GK------------------VFYVWLDApiGYISATKE--LSGNEEKWKEWWPNDpd 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 566 -----FIaeGIDQTRgwFYTllVISTALFNKAPFK---NLIASGLVLaADGQKMSKRKKNYPDPMEVVHKYGADALRLYL 637
Cdd:pfam09334 279 telvhFI--GKDIIY--FHT--IFWPAMLLGAGYRlptTVFAHGYLT-YEGGKMSKSRGNVVWPSEALDRFPPDALRYYL 351
|
....*
gi 24668547 638 I-NSP 641
Cdd:pfam09334 352 ArNRP 356
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
422-638 |
2.70e-07 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 54.07 E-value: 2.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 422 PSWFVRVEHMSKNLLD--CSSQTYWVPDFVKeKRFGNWLKEA-RDWAISR-NRYWGTPIPiwrspsGDEtvvigsikqla 497
Cdd:cd00814 138 EHYFFRLSKFQDRLLEwlEKNPDFIWPENAR-NEVLSWLKEGlKDLSITRdLFDWGIPVP------LDP----------- 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 498 elsgvqvedlhresiDHieipsavpgnpplrriapVFDCWFES--GSMPFAQQHF-PFENEKDFMNNFPAD--FIaeGID 572
Cdd:cd00814 200 ---------------GK------------------VIYVWFDAliGYISATGYYNeEWGNSWWWKDGWPELvhFI--GKD 244
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24668547 573 QTRgwFYTllVISTALFNKA---PFKNLIASGLVLAaDGQKMSKRKKNYPDPMEVVHKYGADALRLYLI 638
Cdd:cd00814 245 IIR--FHA--IYWPAMLLGAglpLPTRIVAHGYLTV-EGKKMSKSRGNVVDPDDLLERYGADALRYYLL 308
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
56-198 |
1.04e-06 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 52.68 E-value: 1.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 56 PFATGLPHYGHILAGTIKDIVTRYAYQQGYHVdrRF--GWDCHGLPVEFEIDKLlnikgpedvakmGIAAynaecRKIVM 133
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDV--LFvcGTDEHGTPIELKAEKE------------GITP-----EELVD 68
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24668547 134 RYADEWENVVTRVGrwIDFKNDYKTLYPWYMESIWWIFKQLFDKGLVYQGVKVMPYSTACTTSLS 198
Cdd:pfam09334 69 RYHEIHREDFKKFN--ISFDDYGRTTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLP 131
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
593-638 |
1.67e-05 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 49.03 E-value: 1.67e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 24668547 593 PFKNLIASGLVLAaDGQKMSKRKKNYPDPMEVVHKYGADALRLYLI 638
Cdd:PRK12267 283 LPKKVFAHGWWLM-KDGKMSKSKGNVVDPEELVDRYGLDALRYYLL 327
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
708-789 |
3.09e-05 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 44.42 E-value: 3.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 708 IDVWILSFKESLLEFFATEMKMYRLYTVVPRLTKFIDQLtNWYVRLNRRRIKGELGADQciqSLDTLYDVLYTMVKMMAP 787
Cdd:cd07375 40 ADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNEL-NWYLDELKPALQTEELREA---VLAVLRAALVVLTKLLAP 115
|
..
gi 24668547 788 FT 789
Cdd:cd07375 116 FT 117
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
407-669 |
7.40e-05 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 46.80 E-value: 7.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 407 PFCWRSDTPLIYKAVPSWFVRVEHMSKNLLDcssqTY-WVPDFVK-EKRFG---NWLKE-ARDWAISRNRY-WGTPIPiw 479
Cdd:PRK11893 142 YRCPPTGAPVEWVEEESYFFRLSKYQDKLLE----LYeANPDFIQpASRRNeviSFVKSgLKDLSISRTNFdWGIPVP-- 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 480 rspsGDETVVIGsikqlaelsgVQVEDLhresidhieipsavpgnppLRRIAPVFDcwfesgsmPFAQQhfpfENEKDFM 559
Cdd:PRK11893 216 ----GDPKHVIY----------VWFDAL-------------------TNYLTALGY--------PDDEE----LLAELFN 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 560 NNFPAD--FIaeGIDQTRgwFYTllVISTALfnkapfknLIASGL-----VLA-----ADGQKMSKRKKNYPDPMEVVHK 627
Cdd:PRK11893 251 KYWPADvhLI--GKDILR--FHA--VYWPAF--------LMAAGLplpkrVFAhgfltLDGEKMSKSLGNVIDPFDLVDE 316
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 24668547 628 YGADALRLYLinspvvraesLRFKEEG-VRDIIKDVFLPWYNA 669
Cdd:PRK11893 317 YGVDAVRYFL----------LREIPFGqDGDFSREAFINRINA 349
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
582-640 |
1.32e-03 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 41.41 E-value: 1.32e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 24668547 582 LVISTALFNKAPFKNLIASGLVLAaDGQKMSKRKKNYPDPMEVVHKYGADALRLYLINS 640
Cdd:cd00672 147 IAQSEAATGKPFARYWLHTGHLTI-DGEKMSKSLGNFITVRDALKKYDPEVLRLALLSS 204
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
55-193 |
1.39e-03 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 42.56 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668547 55 PPFATGLPHYGHilAGT--IKDIVTRYAYQQGYHVdrRF--GWDCHGLPVEFEIDKlLNIKgPEDVakmgiaaynaeCRK 130
Cdd:PRK11893 9 IYYPNGKPHIGH--AYTtlAADVLARFKRLRGYDV--FFltGTDEHGQKIQRKAEE-AGIS-PQEL-----------ADR 71
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24668547 131 IVMRYADEWENvvtrvgrwIDFKNDY--KTLYPWYMESIWWIFKQLFDKGLVYQGVKVMPYSTAC 193
Cdd:PRK11893 72 NSAAFKRLWEA--------LNISYDDfiRTTDPRHKEAVQEIFQRLLANGDIYLGKYEGWYCVRC 128
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
748-800 |
4.83e-03 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 38.34 E-value: 4.83e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 24668547 748 NWYvrlnRRRIKGELGADqciqsldTLYDVLYTMVKMMAPFTPYLTEYIFQRL 800
Cdd:cd07959 76 DWY----RERGGAGMNKD-------LLRRFIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| |
