|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
439-686 |
2.97e-141 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 423.43 E-value: 2.97e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALAWMSWRERKLPRGGILADDMGLGKTLTMISSVLACKNGQEMSEGKdessdsdseddknKKRKSVTGWKSKG 518
Cdd:cd18072 1 LLLHQKQALAWLLWRERQKPRGGILADDMGLGKTLTMIALILAQKNTQNRKEEE-------------KEKALTEWESKKD 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 519 RKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNRETKGKYLRDYDIVVTTYQIVAREHKSL------SAV 592
Cdd:cd18072 68 STLVPSAGTLVVCPASLVHQWKNEVESRVASNKLRVCLYHGPNRERIGEVLRDYDIVITTYSLVAKEIPTYkeesrsSPL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 593 FGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNKSAGGQ 672
Cdd:cd18072 148 FRIAWARIILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFLRCSPFDDLKVWKKQVDNKSRKGG 227
|
250
....*....|....
gi 24644932 673 NRLNLLMKSLMLRR 686
Cdd:cd18072 228 ERLNILTKSLLLRR 241
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
287-1041 |
1.88e-120 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 385.35 E-value: 1.88e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 287 VSQVVYDEEMRKLAEKRVQVSDAEKLFEKVAHKLPDKGSQIMKRIDTLRRELAMDEQWISALRVQQSNVPAVRVVKPTLN 366
Cdd:COG0553 77 LSALALLLLRLLLALLLLALLLLLAGLLALALLLLALLGLLLSLALLLLLLLLLLLLLLALLLVLLAALLLLLLLLLLLA 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 367 PPRAPSIDTLDWDELSEAVNEIKPVYTGAQGMATFNNQKALTLESLKDLHVSLEDLPGPEV-------------LAEDPV 433
Cdd:COG0553 157 LLLGRLLLLALLLLALEALLLLGLLLALALLALLELALLAAEAELLLLLELLLELELLAEAavdafrlrrlreaLESLPA 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 434 GLKVSLMNHQKHALAWMsWRERKLPRGGILADDMGLGKTLTMISSVLACKNgqemsegkdessdsdseddknkkrksvtg 513
Cdd:COG0553 237 GLKATLRPYQLEGAAWL-LFLRRLGLGGLLADDMGLGKTIQALALLLELKE----------------------------- 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 514 wkskgRKDTRRggTLVVCPASLLRQWESEVEskvsR--QKLTVCVHHG-NNRETKGKYLRDYDIVVTTYQIVAREHKSLS 590
Cdd:COG0553 287 -----RGLARP--VLIVAPTSLVGNWQRELA----KfaPGLRVLVLDGtRERAKGANPFEDADLVITSYGLLRRDIELLA 355
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 591 AVfgvKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRcsPfDDLHTWKKW------- 663
Cdd:COG0553 356 AV---DWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDFLN--P-GLLGSLKAFrerfarp 429
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 664 IDNKSAGGQNRLNLLMKSLMLRRTKAQLQSDgklnsLPNKELRLIEISLDKEEMNVYQTVMTYSRtlfaqflhqraeret 743
Cdd:COG0553 430 IEKGDEEALERLRRLLRPFLLRRTKEDVLKD-----LPEKTEETLYVELTPEQRALYEAVLEYLR--------------- 489
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 744 dfnyrsdankptynqikdpngayykmhekfARMAGSKKEVKSHDILVLLLRLRQICCHPGLidamldgeesqtmgdhssd 823
Cdd:COG0553 490 ------------------------------RELEGAEGIRRRGLILAALTRLRQICSHPAL------------------- 520
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 824 sdtpeidllaqlnklaitdtstdgqqsvanagddgppLLPDEARIAkasknllkrsnpvfnlhRPSSKINMVIQILKTsi 903
Cdd:COG0553 521 -------------------------------------LLEEGAELS-----------------GRSAKLEALLELLEE-- 544
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 904 LKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNDRNNqKRVLLLSLTAGGVGLNLIGANHL 983
Cdd:COG0553 545 LLAEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPE-APVFLISLKAGGEGLNLTAADHV 623
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*...
gi 24644932 984 LLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKLDLADGVL 1041
Cdd:COG0553 624 IHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRALAESVL 681
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
442-805 |
1.09e-96 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 308.07 E-value: 1.09e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 442 HQKHALAWMSWRERKLPRGGILADDMGLGKTLTMISSVLACKNGQEMsegkdessdsdseddknkkrksvtgwkskgrkd 521
Cdd:pfam00176 1 YQIEGVNWMLSLENNLGRGGILADEMGLGKTLQTISLLLYLKHVDKN--------------------------------- 47
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 522 tRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNRET-----KGKYLRDYDIVVTTYQIVaREHKSLSAVfgVK 596
Cdd:pfam00176 48 -WGGPTLIVVPLSLLHNWMNEFERWVSPPALRVVVLHGNKRPQerwknDPNFLADFDVVITTYETL-RKHKELLKK--VH 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 597 WRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDN-----KSAGG 671
Cdd:pfam00176 124 WHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRpiergGGKKG 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 672 QNRLNLLMKSLMLRRTKAQLQSdgklnSLPNKELRLIEISLDKEEMNVYQTVMTysrtlfaqflhqraeretdfnyrsda 751
Cdd:pfam00176 204 VSRLHKLLKPFLLRRTKKDVEK-----SLPPKVEYILFCRLSKLQRKLYQTFLL-------------------------- 252
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 24644932 752 nKPTYNQIKDpngayykmhekfarmaGSKKEVKSHDILVLLLRLRQICCHPGLI 805
Cdd:pfam00176 253 -KKDLNAIKT----------------GEGGREIKASLLNILMRLRKICNHPGLI 289
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
439-686 |
5.48e-87 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 279.94 E-value: 5.48e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALAWMswrerkLPRGGILADDMGLGKTLTMISSVLACKNGqemsegkdessdsdseddKNKKRKSVTGWKSKG 518
Cdd:cd18008 1 LLPYQKQGLAWM------LPRGGILADEMGLGKTIQALALILATRPQ------------------DPKIPEELEENSSDP 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 519 RKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNRETKGKYLRDYDIVVTTYQIVAREH------------ 586
Cdd:cd18008 57 KKLYLSKTTLIVVPLSLLSQWKDEIEKHTKPGSLKVYVYHGSKRIKSIEELSDYDIVITTYGTLASEFpknkkgggrdsk 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 587 -KSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWI- 664
Cdd:cd18008 137 eKEASPLHRIRWYRVILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWFNSDIs 216
|
250 260
....*....|....*....|....*
gi 24644932 665 ---DNKSAGGQNRLNLLMKSLMLRR 686
Cdd:cd18008 217 kpfSKNDRKALERLQALLKPILLRR 241
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
439-686 |
2.07e-57 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 198.08 E-value: 2.07e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALAWMSWRE-------------------------RKLP---RGGILADDMGLGKTLTMISSVLACKngqemse 490
Cdd:cd18071 1 LLPHQKQALAWMVSREnsqdlppfweeavglflntitnfsqKKRPelvRGGILADDMGLGKTLTTISLILANF------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 491 gkdessdsdseddknkkrksvtgwkskgrkdtrrggTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNRETKGKYLR 570
Cdd:cd18071 74 ------------------------------------TLIVCPLSVLSNWETQFEEHVKPGQLKVYTYHGGERNRDPKLLS 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 571 DYDIVVTTYQIVAREH--KSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKF 648
Cdd:cd18071 118 KYDIVLTTYNTLASDFgaKGDSPLHTINWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLGSLLSF 197
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 24644932 649 LRCSPFDDLHTWKKWIDNK----SAGGQNRLNLLMKSLMLRR 686
Cdd:cd18071 198 LHLKPFSNPEYWRRLIQRPltmgDPTGLKRLQVLMKQITLRR 239
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
889-1017 |
2.56e-51 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 176.51 E-value: 2.56e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 889 SSKINMVIQILKTsiLKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNDrNNQKRVLLLSL 968
Cdd:cd18793 10 SGKLEALLELLEE--LREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNE-DPDIRVFLLST 86
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 24644932 969 TAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFM 1017
Cdd:cd18793 87 KAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
439-654 |
9.64e-47 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 165.43 E-value: 9.64e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALAWMSWRERKlPRGGILADDMGLGKTLTMISsVLAckngqemsegkdessdsdseddknkkrksvtgWKSKG 518
Cdd:cd17919 1 LRPYQLEGLNFLLELYEN-GPGGILADEMGLGKTLQAIA-FLA--------------------------------YLLKE 46
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 519 RKDTRRggTLVVCPASLLRQWESEVEsKVSRQkLTVCVHHGNNRE----TKGKYLRDYDIVVTTYQIVAREHKSLSAVfg 594
Cdd:cd17919 47 GKERGP--VLVVCPLSVLENWEREFE-KWTPD-LRVVVYHGSQREraqiRAKEKLDKFDVVLTTYETLRRDKASLRKF-- 120
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 595 vKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCsPF 654
Cdd:cd17919 121 -RWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLLTGTPLQNNLEELWALLDFLDP-PF 178
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
439-685 |
1.68e-44 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 161.74 E-value: 1.68e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALAWMswrerkLPRGGILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSkg 518
Cdd:cd18070 1 LLPYQRRAVNWM------LVPGGILADEMGLGKTVEVLALILLHPRPDNDLDAADDDSDEMVCCPDCLVAETPVSSKA-- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 519 rkdtrrggTLVVCPASLLRQWESEVEsKVSRQKLTVCVHHGNNRETKGK-----YLRDYDIVVTTYQIVARE-------H 586
Cdd:cd18070 73 --------TLIVCPSAILAQWLDEIN-RHVPSSLKVLTYQGVKKDGALAspapeILAEYDIVVTTYDVLRTElhyaeanR 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 587 KSL------------SAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPF 654
Cdd:cd18070 144 SNRrrrrqkryeappSPLVLVEWWRVCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLSFLGVEPF 223
|
250 260 270
....*....|....*....|....*....|...
gi 24644932 655 DDLHTWKK-WIDN-KSAGGQNRLNLLMKSLMLR 685
Cdd:cd18070 224 CDSDWWARvLIRPqGRNKAREPLAALLKELLWR 256
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
435-688 |
1.31e-43 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 157.73 E-value: 1.31e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 435 LKVSLMNHQKHALAWMSwRERKLPRGGILADDMGLGKTLTMISSVLACKNgqemsegkdessdsdseddKNKKRKSvtgw 514
Cdd:cd18012 1 LKATLRPYQKEGFNWLS-FLRHYGLGGILADDMGLGKTLQTLALLLSRKE-------------------EGRKGPS---- 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 515 kskgrkdtrrggtLVVCPASLLRQWESEVeskvsrQK----LTVCVHHGNNRETKGKY-LRDYDIVVTTYQIVAREHKSL 589
Cdd:cd18012 57 -------------LVVAPTSLIYNWEEEA------AKfapeLKVLVIHGTKRKREKLRaLEDYDLVITSYGLLRRDIELL 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 590 SAVfgvKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLrcSP--------FDDLhtWK 661
Cdd:cd18012 118 KEV---KFHYLVLDEAQNIKNPQTKTAKAVKALKADHRLALTGTPIENHLGELWSIFDFL--NPgllgsykrFKKR--FA 190
|
250 260
....*....|....*....|....*...
gi 24644932 662 KWIDN-KSAGGQNRLNLLMKSLMLRRTK 688
Cdd:cd18012 191 KPIEKdGDEEALEELKKLISPFILRRLK 218
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
447-1036 |
1.07e-39 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 159.97 E-value: 1.07e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 447 LAWMSWRERKLPRG--GILADDMGLGKTLTMISSVlackngqemsegkdessdsdseddknkkrksvtGWKSKGRKDTrr 524
Cdd:PLN03142 175 LAGLNWLIRLYENGinGILADEMGLGKTLQTISLL---------------------------------GYLHEYRGIT-- 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 525 GGTLVVCPASLLRQWESEVESKVSrqKLTVCVHHGNNRETKgkYLRD-------YDIVVTTYQIVAREHKSLSAVfgvKW 597
Cdd:PLN03142 220 GPHMVVAPKSTLGNWMNEIRRFCP--VLRAVKFHGNPEERA--HQREellvagkFDVCVTSFEMAIKEKTALKRF---SW 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 598 RRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNKSAGGQ----N 673
Cdd:PLN03142 293 RYIIIDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQISGENDQqevvQ 372
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 674 RLNLLMKSLMLRRTKAQLQSdgklnSLPNKELRLIEISLDKEEMNVYqtvmtysrtlfaqflhqRAERETDfnyrsdank 753
Cdd:PLN03142 373 QLHKVLRPFLLRRLKSDVEK-----GLPPKKETILKVGMSQMQKQYY-----------------KALLQKD--------- 421
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 754 ptynqIKDPNGAyykmhekfarmaGSKKEvkshdILVLLLRLRQICCHPGLidamLDGEESqtmgdhssdsdtpeidlla 833
Cdd:PLN03142 422 -----LDVVNAG------------GERKR-----LLNIAMQLRKCCNHPYL----FQGAEP------------------- 456
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 834 qlnklaitdtstdgqqsvanagddGPPLLPDEARIAKASK-----NLLKRsnpvfnlhrpsskinmviqilktsiLKSSD 908
Cdd:PLN03142 457 ------------------------GPPYTTGEHLVENSGKmvlldKLLPK-------------------------LKERD 487
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 909 DKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDL 988
Cdd:PLN03142 488 SRVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPGSEKFVFLLSTRAGGLGINLATADIVILYDS 567
|
570 580 590 600
....*....|....*....|....*....|....*....|....*...
gi 24644932 989 HWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKLDL 1036
Cdd:PLN03142 568 DWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLAL 615
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
439-649 |
1.92e-32 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 126.31 E-value: 1.92e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALAWMSWRER-KLprGGILADDMGLGKTLTMISSVLACKNGQEMSegkdessdsdsedDKNKKRKSvtgwksk 517
Cdd:cd17999 1 LRPYQQEGINWLAFLNKyNL--HGILCDDMGLGKTLQTLCILASDHHKRANS-------------FNSENLPS------- 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 518 grkdtrrggtLVVCPASLLRQWESEVESKVSRQKLTVCVHHG--NNRETKGKYLRDYDIVVTTYQIVAREHKSLSAVFgv 595
Cdd:cd17999 59 ----------LVVCPPTLVGHWVAEIKKYFPNAFLKPLAYVGppQERRRLREQGEKHNVIVASYDVLRNDIEVLTKIE-- 126
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 24644932 596 kWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFL 649
Cdd:cd17999 127 -WNYCVLDEGHIIKNSKTKLSKAVKQLKANHRLILSGTPIQNNVLELWSLFDFL 179
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
439-686 |
1.00e-31 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 124.41 E-value: 1.00e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALAWMSWRERKlPRGGILADDMGLGKTLTMISSVLAC--KNGQEmsegkdessdsdSEDDKNKKRKsvtgwKS 516
Cdd:cd18005 1 LRDYQREGVEFMYDLYKN-GRGGILGDDMGLGKTVQVIAFLAAVlgKTGTR------------RDRENNRPRF-----KK 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 517 KGRKDTRRGGTLVVCPASLLRQWESEVESKVSrqkLTVCVHHGNNR--ETKGKY-LRDYDIVVTTYQIVAREHKSLSavf 593
Cdd:cd18005 63 KPPASSAKKPVLIVAPLSVLYNWKDELDTWGH---FEVGVYHGSRKddELEGRLkAGRLEVVVTTYDTLRRCIDSLN--- 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 594 GVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNKSAGGQN 673
Cdd:cd18005 137 SINWSAVIADEAHRIKNPKSKLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSRSQFKKHFSEPIKRGQR 216
|
250 260
....*....|....*....|....*....
gi 24644932 674 R----------------LNLLMKSLMLRR 686
Cdd:cd18005 217 HtatarelrlgrkrkqeLAVKLSKFFLRR 245
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
439-649 |
1.72e-31 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 123.25 E-value: 1.72e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALAWMsWRERKLPRGGILADDMGLGKTLTMISSVlackngQEMSEGKDEssdsdseddknkkrKSVtgwkskg 518
Cdd:cd18001 1 LYPHQREGVAWL-WSLHDGGKGGILADDMGLGKTVQICAFL------SGMFDSGLI--------------KSV------- 52
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 519 rkdtrrggtLVVCPASLLRQWESEVESKVSRqkLTVCVHHGNNRETKGKYL----RDYDIVVTTYQIVAREHKSLSAVF- 593
Cdd:cd18001 53 ---------LVVMPTSLIPHWVKEFAKWTPG--LRVKVFHGTSKKERERNLeriqRGGGVLLTTYGMVLSNTEQLSADDh 121
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 24644932 594 -GVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFL 649
Cdd:cd18001 122 dEFKWDYVILDEGHKIKNSKTKSAKSLREIPAKNRIILTGTPIQNNLKELWALFDFA 178
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
439-688 |
3.05e-30 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 119.35 E-value: 3.05e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALAWM-SWRERKLprGGILADDMGLGKTLTMISsvlackngqemsegkdessdsdseddknkkrksVTGWKSK 517
Cdd:cd17997 4 MRDYQIRGLNWLiSLFENGI--NGILADEMGLGKTLQTIS---------------------------------LLGYLKH 48
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 518 GRKDTrrGGTLVVCPASLLRQWESEVESKVSrqKLTVCVHHGNnRETKGKYLRD------YDIVVTTYQIVAREHKSLSA 591
Cdd:cd17997 49 YKNIN--GPHLIIVPKSTLDNWMREFKRWCP--SLRVVVLIGD-KEERADIIRDvllpgkFDVCITSYEMVIKEKTVLKK 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 592 VfgvKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNKSAGG 671
Cdd:cd17997 124 F---NWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNRLLLTGTPLQNNLHELWALLNFLLPDVFTSSEDFDEWFNVNNCDD 200
|
250 260
....*....|....*....|..
gi 24644932 672 QN-----RLNLLMKSLMLRRTK 688
Cdd:cd17997 201 DNqevvqRLHKVLRPFLLRRIK 222
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
439-686 |
1.12e-27 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 112.06 E-value: 1.12e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALAWM-SWRERKLprGGILADDMGLGKTLTMIS--SVLACKNGQemsegkdessdsdseddknkkrksvtgWk 515
Cdd:cd18003 1 LREYQHIGLDWLaTLYEKNL--NGILADEMGLGKTIQTIAllAHLACEKGN---------------------------W- 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 516 skgrkdtrrGGTLVVCPASLLRQWESEVeskvsrQK----LTVCVHHGNNRETKGKY-----LRDYDIVVTTYQIVAREH 586
Cdd:cd18003 51 ---------GPHLIVVPTSVMLNWEMEF------KRwcpgFKILTYYGSAKERKLKRqgwmkPNSFHVCITSYQLVVQDH 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 587 KSLSAVfgvKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDN 666
Cdd:cd18003 116 QVFKRK---KWKYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLLTGTPLQNSLMELWSLMHFLMPHIFQSHQEFKEWFSN 192
|
250 260 270
....*....|....*....|....*....|.
gi 24644932 667 K----SAGGQN-------RLNLLMKSLMLRR 686
Cdd:cd18003 193 PltamSEGSQEeneelvrRLHKVLRPFLLRR 223
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
439-686 |
1.01e-26 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 109.26 E-value: 1.01e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALAWMS--WRERklpRGGILADDMGLGKT---LTMISSVLackngQEMSEgkdessdsdseddknkkrksvtg 513
Cdd:cd17995 1 LRDYQLEGVNWLLfnWYNR---RNCILADEMGLGKTiqsIAFLEHLY-----QVEGI----------------------- 49
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 514 wkskgrkdtrRGGTLVVCPASLLRQWESEVESKVSrqkLTVCVHHGN--NRETKGKYLRDY--------------DIVVT 577
Cdd:cd17995 50 ----------RGPFLVIAPLSTIPNWQREFETWTD---MNVVVYHGSgeSRQIIQQYEMYFkdaqgrkkkgvykfDVLIT 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 578 TYQIVAREHKSLSAVfgvKWRRIILDEAHVVRNhkSQSSLAVCdLRgKYRWA----LTGTPIQNKELDVYALLKFLRCSP 653
Cdd:cd17995 117 TYEMVIADAEELRKI---PWRVVVVDEAHRLKN--RNSKLLQG-LK-KLTLEhkllLTGTPLQNNTEELWSLLNFLEPEK 189
|
250 260 270
....*....|....*....|....*....|....
gi 24644932 654 FDDLHTWK-KWIDNKSAGGQNRLNLLMKSLMLRR 686
Cdd:cd17995 190 FPSSEEFLeEFGDLKTAEQVEKLQALLKPYMLRR 223
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
439-640 |
2.20e-25 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 104.71 E-value: 2.20e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALAWMSWRERKLPrGGILADDMGLGKTLtMISSVLACKNGQEMSegkdessdsdseddknkkrksvtgwkskg 518
Cdd:cd18000 1 LFKYQQTGVQWLWELHCQRV-GGILGDEMGLGKTI-QIIAFLAALHHSKLG----------------------------- 49
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 519 rkdtrRGGTLVVCPASLLRQWESEVESKVSrqKLTVCVHH-----GNNRETKGKYLR----------DYDIVVTTYQIVa 583
Cdd:cd18000 50 -----LGPSLIVCPATVLKQWVKEFHRWWP--PFRVVVLHssgsgTGSEEKLGSIERksqlirkvvgDGGILITTYEGF- 121
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 24644932 584 REHKSLsaVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQN--KEL 640
Cdd:cd18000 122 RKHKDL--LLNHNWQYVILDEGHKIRNPDAEITLACKQLRTPHRLILSGTPIQNnlKEL 178
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
461-686 |
1.44e-23 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 100.27 E-value: 1.44e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 461 GILADDMGLGKTLTMISsVLAckngqEMSEGKDEssdsdseddknkkrksvtgWkskgrkdtrrGGTLVVCPASLLRQWE 540
Cdd:cd18002 22 GILADEMGLGKTVQSIA-VLA-----HLAEEHNI-------------------W----------GPFLVIAPASTLHNWQ 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 541 SEVESKVSRQKLTVCVHHGNNRET-------KGKYLRD--YDIVVTTYQIVAREHKSLSavfGVKWRRIILDEAHVVRNH 611
Cdd:cd18002 67 QEISRFVPQFKVLPYWGNPKDRKVlrkfwdrKNLYTRDapFHVVITSYQLVVQDEKYFQ---RVKWQYMVLDEAQAIKSS 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 612 KSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKW----IDNKSAGGQ-------NRLNLLMK 680
Cdd:cd18002 144 SSSRWKTLLSFHCRNRLLLTGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWfskdIESHAENKTglnehqlKRLHMILK 223
|
....*.
gi 24644932 681 SLMLRR 686
Cdd:cd18002 224 PFMLRR 229
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
439-704 |
1.14e-22 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 98.20 E-value: 1.14e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALAWM-SWRERKLprGGILADDMGLGKTLTMISSVLACKNGQEMSegkdessdsdseddknkkrksvtgwksk 517
Cdd:cd18064 16 LRDYQVRGLNWLiSLYENGI--NGILADEMGLGKTLQTISLLGYMKHYRNIP---------------------------- 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 518 grkdtrrGGTLVVCPASLLRQWESEVESKVSRQKlTVCVHhgNNRETKGKYLRD------YDIVVTTYQIVAREhKSLSA 591
Cdd:cd18064 66 -------GPHMVLVPKSTLHNWMAEFKRWVPTLR-AVCLI--GDKDQRAAFVRDvllpgeWDVCVTSYEMLIKE-KSVFK 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 592 VFgvKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWID-NKSAG 670
Cdd:cd18064 135 KF--NWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSAEDFDSWFDtNNCLG 212
|
250 260 270
....*....|....*....|....*....|....*..
gi 24644932 671 GQN---RLNLLMKSLMLRRTKAQLQsdgklNSLPNKE 704
Cdd:cd18064 213 DQKlveRLHMVLRPFLLRRIKADVE-----KSLPPKK 244
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
439-688 |
1.84e-22 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 97.44 E-value: 1.84e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALAWM-SWRERKLprGGILADDMGLGKTLTMISsvLACKngqeMSEGKDEssdsdseddknkkrksvtgwksk 517
Cdd:cd17996 4 LKEYQLKGLQWMvSLYNNNL--NGILADEMGLGKTIQTIS--LITY----LMEKKKN----------------------- 52
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 518 grkdtrRGGTLVVCPASLLRQWESEVESKVSrqKLTVCVHHG--NNRETKGKYLR--DYDIVVTTYQIVAREHKSLSAVf 593
Cdd:cd17996 53 ------NGPYLVIVPLSTLSNWVSEFEKWAP--SVSKIVYKGtpDVRKKLQSQIRagKFNVLLTTYEYIIKDKPLLSKI- 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 594 gvKWRRIILDEAHVVRNHKSQSSLavcDL----RGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNKSA 669
Cdd:cd17996 124 --KWKYMIIDEGHRMKNAQSKLTQ---TLntyyHARYRLLLTGTPLQNNLPELWALLNFLLPKIFKSCKTFEQWFNTPFA 198
|
250 260 270
....*....|....*....|....*....|....*
gi 24644932 670 --GGQ--------------NRLNLLMKSLMLRRTK 688
Cdd:cd17996 199 ntGEQvkielneeetlliiRRLHKVLRPFLLRRLK 233
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
447-688 |
2.08e-22 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 97.46 E-value: 2.08e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 447 LAWMSWRERKLPRG--GILADDMGLGKTLTMISsVLACkngqeMSEGKDEssdsdseddknkkrksvtgwkskgrkdtrr 524
Cdd:cd18009 9 LEGMEWLRMLWENGinGILADEMGLGKTIQTIA-LLAH-----LRERGVW------------------------------ 52
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 525 GGTLVVCPASLLRQWESEVESKVSrqKLTVCVHHGNNRE---------TKGKYLRDYDIVVTTYQIVAREHKSLSAVfgv 595
Cdd:cd18009 53 GPFLVIAPLSTLPNWVNEFARFTP--SVPVLLYHGTKEErerlrkkimKREGTLQDFPVVVTSYEIAMRDRKALQHY--- 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 596 KWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWID----NKSAGG 671
Cdd:cd18009 128 AWKYLIVDEGHRLKNLNCRLIQELKTFNSDNRLLLTGTPLQNNLSELWSLLNFLLPDVFDDLSSFESWFDfsslSDNAAD 207
|
250 260
....*....|....*....|....*....
gi 24644932 672 ---------QNRLNLL---MKSLMLRRTK 688
Cdd:cd18009 208 isnlseereQNIVHMLhaiLKPFLLRRLK 236
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
442-686 |
4.28e-22 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 96.59 E-value: 4.28e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 442 HQKHALAWMsWR----ERKLPRGG-ILADDMGLGKTLTMISSVLACkngqeMSEGKDessdsdseddknkkrksvtgwks 516
Cdd:cd18004 4 HQREGVQFL-YDcltgRRGYGGGGaILADEMGLGKTLQAIALVWTL-----LKQGPY----------------------- 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 517 kGRKDTRRggTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNRETK-----GKYLRDYDIVVTTYQIVAREHKSLSA 591
Cdd:cd18004 55 -GKPTAKK--ALIVCPSSLVGNWKAEFDKWLGLRRIKVVTADGNAKDVKasldfFSSASTYPVLIISYETLRRHAEKLSK 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 592 --VFGVkwrrIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDN--- 666
Cdd:cd18004 132 kiSIDL----LICDEGHRLKNSESKTTKALNSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEpil 207
|
250 260 270
....*....|....*....|....*....|...
gi 24644932 667 -------------KSAGGQNRLNLLMKSLMLRR 686
Cdd:cd18004 208 rsrdpdaseedkeLGAERSQELSELTSRFILRR 240
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
439-647 |
1.15e-21 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 94.10 E-value: 1.15e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALAWMswreRKLPRGGILADDMGLGKTLTMISSVLACKngqemsegkdessdsdseddknkkrksvtgwkskg 518
Cdd:smart00487 9 LRPYQKEAIEAL----LSGLRDVILAAPTGSGKTLAALLPALEAL----------------------------------- 49
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 519 rKDTRRGGTLVVCP-ASLLRQWESEVESKVSRQKL-TVCVHHGNNRETKGKYLR--DYDIVVTTYQIVAReHKSLSAVFG 594
Cdd:smart00487 50 -KRGKGGRVLVLVPtRELAEQWAEELKKLGPSLGLkVVGLYGGDSKREQLRKLEsgKTDILVTTPGRLLD-LLENDKLSL 127
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 24644932 595 VKWRRIILDEAHVVRN--HKSQSSLAVCDLRGK-YRWALTGTPIQNKELDVYALLK 647
Cdd:smart00487 128 SNVDLVILDEAHRLLDggFGDQLEKLLKLLPKNvQLLLLSATPPEEIENLLELFLN 183
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
438-688 |
4.17e-21 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 93.54 E-value: 4.17e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 438 SLMNHQKHALAWM-SWRERKLprGGILADDMGLGKTLTMISSVLACKNGQEMSegkdessdsdseddknkkrksvtgwks 516
Cdd:cd18065 15 TLRDYQVRGLNWMiSLYENGV--NGILADEMGLGKTLQTIALLGYLKHYRNIP--------------------------- 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 517 kgrkdtrrGGTLVVCPASLLRQWESEVESKVSRQKLTVCVhhgNNRETKGKYLRD------YDIVVTTYQIVAREhKSLS 590
Cdd:cd18065 66 --------GPHMVLVPKSTLHNWMNEFKRWVPSLRAVCLI---GDKDARAAFIRDvmmpgeWDVCVTSYEMVIKE-KSVF 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 591 AVFgvKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNKSAG 670
Cdd:cd18065 134 KKF--NWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWFDTKNCL 211
|
250 260
....*....|....*....|..
gi 24644932 671 GQN----RLNLLMKSLMLRRTK 688
Cdd:cd18065 212 GDQklveRLHAVLKPFLLRRIK 233
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
439-686 |
1.68e-20 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 91.11 E-value: 1.68e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALAW-MSWRERKLprggiLADDMGLGKTLTMISSVLACKNGqemsegkdessdsdseddknkkrksvtgWKsk 517
Cdd:cd18010 1 LLPFQREGVCFaLRRGGRVL-----IADEMGLGKTVQAIAIAAYYREE----------------------------WP-- 45
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 518 grkdtrrggTLVVCPASLLRQWESEVESKVSRQKLT--VCVHHGNNretkGKYLRDYDIVVTTYQIVAREHKSLSAVfgv 595
Cdd:cd18010 46 ---------LLIVCPSSLRLTWADEIERWLPSLPPDdiQVIVKSKD----GLRDGDAKVVIVSYDLLRRLEKQLLAR--- 109
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 596 KWRRIILDEAHVVRNHKSQSSLAVCDL--RGKYRWALTGTPIQNKELDVYALLKFLR---CSPFDDLH---------TWK 661
Cdd:cd18010 110 KFKVVICDESHYLKNSKAKRTKAALPLlkRAKRVILLSGTPALSRPIELFTQLDALDpklFGRFHDFGrrycaakqgGFG 189
|
250 260
....*....|....*....|....*...
gi 24644932 662 KWIDnksaGGQNR---LNLLMKSLMLRR 686
Cdd:cd18010 190 WDYS----GSSNLeelHLLLLATIMIRR 213
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
439-654 |
8.47e-20 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 88.21 E-value: 8.47e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALAWMS-WRERKLprGGILADDMGLGKTLTMIS--SVLackngqemsegkdessdsdseddknkkrksvtgwK 515
Cdd:cd17998 1 LKDYQLIGLNWLNlLYQKKL--SGILADEMGLGKTIQVIAflAYL----------------------------------K 44
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 516 SKGRKdtrrGGTLVVCPASLLRQWESEVESKVSrqKLTVCVHHGNNRETKgkYLR--------DYDIVVTTYQIV--ARE 585
Cdd:cd17998 45 EIGIP----GPHLVVVPSSTLDNWLREFKRWCP--SLKVEPYYGSQEERK--HLRydilkgleDFDVIVTTYNLAtsNPD 116
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24644932 586 HKSLSAVFgvKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPF 654
Cdd:cd17998 117 DRSFFKRL--KLNYVVYDEGHMLKNMTSERYRHLMTINANFRLLLTGTPLQNNLLELMSLLNFIMPKPF 183
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
890-1006 |
1.28e-19 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 84.95 E-value: 1.28e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 890 SKINMVIQILKtsilKSSDDKAIVVSQWTSVLDIlRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNdrnNQKRVLLLSLT 969
Cdd:pfam00271 1 EKLEALLELLK----KERGGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFR---KGKIDVLVATD 72
|
90 100 110
....*....|....*....|....*....|....*..
gi 24644932 970 AGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVG 1006
Cdd:pfam00271 73 VAERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
439-686 |
6.95e-19 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 86.34 E-value: 6.95e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALAWMSWReRKLPRGGILADDMGLGKTLTMISsVLACKNGQEMSEGKDessdsdseddknkkrksvtgwkskg 518
Cdd:cd18006 1 LRPYQLEGVNWLLQC-RAEQHGCILGDEMGLGKTCQTIS-LLWYLAGRLKLLGPF------------------------- 53
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 519 rkdtrrggtLVVCPASLLRQWESEVESKVSRQKltvCVHHGNNRETKGKYLRD------YDIVVTTYQIVAREHKSLSAV 592
Cdd:cd18006 54 ---------LVLCPLSVLDNWKEELNRFAPDLS---VITYMGDKEKRLDLQQDikstnrFHVLLTTYEICLKDASFLKSF 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 593 fgvKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPF------DDLHTWKKwIDN 666
Cdd:cd18006 122 ---PWASLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLLTGTPIQNSLQELYALLSFIEPNVFpkdkldDFIKAYSE-TDD 197
|
250 260
....*....|....*....|
gi 24644932 667 KSAGGQNrLNLLMKSLMLRR 686
Cdd:cd18006 198 ESETVEE-LHLLLQPFLLRR 216
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
460-662 |
8.37e-18 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 83.74 E-value: 8.37e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 460 GGILADDMGLGKTLTMISSVLACKngqemsegkdessdsdseddknkkRKSVTGWKSKGRKdtrrggTLVVCPASLLRQW 539
Cdd:cd18066 26 GAILADEMGLGKTLQCISLIWTLL------------------------RQGPYGGKPVIKR------ALIVTPGSLVKNW 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 540 ESEVESKVSRQKLTVCVHHGNNRETKGKYLRDYDIVVTTYQIVARehkSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAV 619
Cdd:cd18066 76 KKEFQKWLGSERIKVFTVDQDHKVEEFIASPLYSVLIISYEMLLR---SLDQISKLNFDLVICDEGHRLKNTSIKTTTAL 152
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 24644932 620 CDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKK 662
Cdd:cd18066 153 TSLSCERRIILTGTPIQNDLQEFFALIDFVNPGILGSLSTYRK 195
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
439-686 |
1.21e-17 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 82.79 E-value: 1.21e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALAWM--SWRERKlprGGILADDMGLGKTLTMISSVLACKNGQEMSegkdessdsdseddknkkrksvtgwks 516
Cdd:cd17993 2 LRDYQLTGLNWLahSWCKGN---NGILADEMGLGKTVQTISFLSYLFHSQQQY--------------------------- 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 517 kgrkdtrrGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNRET---------KGKYLRdYDIVVTTYQIVAREHK 587
Cdd:cd17993 52 --------GPFLVVVPLSTMPAWQREFAKWAPDMNVIVYLGDIKSRDTireyefyfsQTKKLK-FNVLLTTYEIILKDKA 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 588 SLSAVfgvKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQN--KELdvYALLKFLRCSPFddlHTWKKWID 665
Cdd:cd17993 123 FLGSI---KWQYLAVDEAHRLKNDESLLYEALKEFKTNNRLLITGTPLQNslKEL--WALLHFLMPGKF---DIWEEFEE 194
|
250 260
....*....|....*....|....
gi 24644932 666 NKSAG---GQNRLNLLMKSLMLRR 686
Cdd:cd17993 195 EHDEEqekGIADLHKELEPFILRR 218
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
434-686 |
1.73e-16 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 80.05 E-value: 1.73e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 434 GLKVSLMNHQKHALAWM--SWRERKlprGGILADDMGLGKTLTMISSVLACKNGQEMSegkdessdsdseddknkkrksv 511
Cdd:cd18054 16 GENLELRDYQLEGLNWLahSWCKNN---SVILADEMGLGKTIQTISFLSYLFHQHQLY---------------------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 512 tgwkskgrkdtrrGGTLVVCPASLLRQWESEVEskVSRQKLTVCVHHGN--NRETkgkyLRDYD------------IVVT 577
Cdd:cd18054 71 -------------GPFLLVVPLSTLTSWQREFE--IWAPEINVVVYIGDlmSRNT----IREYEwihsqtkrlkfnALIT 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 578 TYQIVAREHKSLSAVfgvKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDdl 657
Cdd:cd18054 132 TYEILLKDKTVLGSI---NWAFLGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFE-- 206
|
250 260 270
....*....|....*....|....*....|..
gi 24644932 658 hTWKKWIDNKSAGGQN---RLNLLMKSLMLRR 686
Cdd:cd18054 207 -FWEDFEEDHGKGRENgyqSLHKVLEPFLLRR 237
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
439-650 |
2.43e-16 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 79.64 E-value: 2.43e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALAWMsWR-------ERKLPRGGILADDMGLGKTLTMIS---SVLACkngqemsegkdessdsdsedDKNKKR 508
Cdd:cd18007 1 LKPHQVEGVRFL-WSnlvgtdvGSDEGGGCILAHTMGLGKTLQVITflhTYLAA--------------------APRRSR 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 509 ksvtgwkskgrkdtrrggTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNRETKG--------KYLRDYDIVVTTYQ 580
Cdd:cd18007 60 ------------------PLVLCPASTLYNWEDEFKKWLPPDLRPLLVLVSLSASKRAdarlrkinKWHKEGGVLLIGYE 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 581 I---VAREHKSLSAVFG--VKWRR------IILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFL 649
Cdd:cd18007 122 LfrnLASNATTDPRLKQefIAALLdpgpdlLVLDEGHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFA 201
|
.
gi 24644932 650 R 650
Cdd:cd18007 202 R 202
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
922-1006 |
7.07e-16 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 73.40 E-value: 7.07e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 922 DILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNdrnNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDR 1001
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFN---NGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGR 77
|
....*
gi 24644932 1002 IYRVG 1006
Cdd:smart00490 78 AGRAG 82
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
439-649 |
7.46e-16 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 77.33 E-value: 7.46e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALawmswRE--RKLPRGGILADDMGLGKTLT--MISSVLAckngqemsegkdessdsdseddknkkrksvtgw 514
Cdd:cd18011 1 PLPHQIDAV-----LRalRKPPVRLLLADEVGLGKTIEagLIIKELL--------------------------------- 42
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 515 kskGRKDTRRggTLVVCPASLLRQWESEVESK-------VSRQKLTVCVHHGNNretkgkYLRDYDIVVTTYQIVAREHK 587
Cdd:cd18011 43 ---LRGDAKR--VLILCPASLVEQWQDELQDKfglpfliLDRETAAQLRRLIGN------PFEEFPIVIVSLDLLKRSEE 111
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24644932 588 SLSAVFGVKWRRIILDEAHVVRNH----KSQSSLAVCDLRGK--YRWALTGTPIQNKELDVYALLKFL 649
Cdd:cd18011 112 RRGLLLSEEWDLVVVDEAHKLRNSgggkETKRYKLGRLLAKRarHVLLLTATPHNGKEEDFRALLSLL 179
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
439-686 |
3.08e-15 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 76.25 E-value: 3.08e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALAWM--SWRERKlprGGILADDMGLGKTLTMISSVlackngQEMSEGKDessdsdseddknkkrksvtgwks 516
Cdd:cd18060 1 LREYQLEGVNWLlfNWYNRQ---NCILADEMGLGKTIQSIAFL------QEVYNVGI----------------------- 48
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 517 kgrkdtrRGGTLVVCPASLLRQWESEVESKVsrqKLTVCVHHGN-------------NRETKGKYL---RDYDIVVTTYQ 580
Cdd:cd18060 49 -------HGPFLVIAPLSTITNWEREFNTWT---EMNTIVYHGSlasrqmiqqyemyCKDSRGRLIpgaYKFDALITTFE 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 581 IVAREHKSLSAVfgvKWRRIILDEAHVV--RNHKSQSSLAVCDLrgKYRWALTGTPIQNKELDVYALLKFLRCSPF-DDL 657
Cdd:cd18060 119 MILSDCPELREI---EWRCVIIDEAHRLknRNCKLLDSLKHMDL--EHKVLLTGTPLQNTVEELFSLLHFLEPSQFpSES 193
|
250 260
....*....|....*....|....*....
gi 24644932 658 HTWKKWIDNKSAGGQNRLNLLMKSLMLRR 686
Cdd:cd18060 194 EFLKDFGDLKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
439-686 |
9.05e-15 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 74.69 E-value: 9.05e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALAWM--SWRERKlprGGILADDMGLGKTLTMISSvlackngqeMSEGKDESSdsdseddknkkrksvtgwks 516
Cdd:cd18058 1 LREYQLEGMNWLlfNWYNRK---NCILADEMGLGKTIQSITF---------LSEIFLMGI-------------------- 48
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 517 kgrkdtrRGGTLVVCPASLLRQWESEVESKVsrqKLTVCVHHGNN-------------RETKGKYLR---DYDIVVTTYQ 580
Cdd:cd18058 49 -------RGPFLIIAPLSTITNWEREFRTWT---EMNAIVYHGSQisrqmiqqyemyyRDEQGNPLSgifKFQVVITTFE 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 581 IVAREHKSLSAVfgvKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTW 660
Cdd:cd18058 119 MILADCPELKKI---NWSCVIIDEAHRLKNRNCKLLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTF 195
|
250 260
....*....|....*....|....*..
gi 24644932 661 -KKWIDNKSAGGQNRLNLLMKSLMLRR 686
Cdd:cd18058 196 lEEFGDLKTEEQVKKLQSILKPMMLRR 222
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
439-686 |
2.31e-14 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 73.50 E-value: 2.31e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALAWM--SWRERklpRGGILADDMGLGKTLTMISSVlackngqemsegkdessdsdseddknkKRKSVTGWks 516
Cdd:cd18061 1 LREYQLEGLNWLlfNWYNR---RNCILADEMGLGKTIQSITFL---------------------------YEILLTGI-- 48
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 517 kgrkdtrRGGTLVVCPASLLRQWESEVESKVSrqkLTVCVHHGN-------------NRETKGKYLRD---YDIVVTTYQ 580
Cdd:cd18061 49 -------RGPFLIIAPLSTIANWEREFRTWTD---LNVVVYHGSlisrqmiqqyemyFRDSQGRIIRGayrFQAIITTFE 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 581 IVAREHKSLSAVfgvKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTW 660
Cdd:cd18061 119 MILGGCPELNAI---DWRCVIIDEAHRLKNKNCKLLEGLKLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTF 195
|
250 260
....*....|....*....|....*..
gi 24644932 661 -KKWIDNKSAGGQNRLNLLMKSLMLRR 686
Cdd:cd18061 196 mQEFGDLKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
439-686 |
2.89e-13 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 70.45 E-value: 2.89e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALAWM--SWRErklPRGGILADDMGLGKTLTMISSVLACKngqemsegkdessdsdseddknkkrksvtgwkS 516
Cdd:cd18059 1 LREYQLEGVNWLlfNWYN---TRNCILADEMGLGKTIQSITFLYEIY--------------------------------L 45
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 517 KGRkdtrRGGTLVVCPASLLRQWESEVESKVsrqKLTVCVHHGNN-------------RETKGKYLR---DYDIVVTTYQ 580
Cdd:cd18059 46 KGI----HGPFLVIAPLSTIPNWEREFRTWT---ELNVVVYHGSQasrrtiqlyemyfKDPQGRVIKgsyKFHAIITTFE 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 581 IVAREHKSLSavfGVKWRRIILDEAHVV--RNHKSQSSLAVCDLrgKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLH 658
Cdd:cd18059 119 MILTDCPELR---NIPWRCVVIDEAHRLknRNCKLLEGLKMMDL--EHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSET 193
|
250 260
....*....|....*....|....*....
gi 24644932 659 TW-KKWIDNKSAGGQNRLNLLMKSLMLRR 686
Cdd:cd18059 194 TFmQEFGDLKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
439-686 |
5.31e-13 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 69.01 E-value: 5.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALAWM--SWRERKlprGGILADDMGLGKTLTMISSVLACkngqeMSEGKDessdsdseddknkkrksvtgwks 516
Cdd:cd17994 1 LHPYQLEGLNWLrfSWAQGT---DTILADEMGLGKTIQTIVFLYSL-----YKEGHS----------------------- 49
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 517 kgrkdtrRGGTLVVCPASLLRQWESEVEskVSRQKLTVCVHHGNNretkgkylrdydIVVTTYQIVAREHKSLSAVfgvK 596
Cdd:cd17994 50 -------KGPFLVSAPLSTIINWEREFE--MWAPDFYVVTYVGDH------------VLLTSYELISIDQAILGSI---D 105
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 597 WRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNKSAGGQ-NRL 675
Cdd:cd17994 106 WAVLVVDEAHRLKNNQSKFFRILNSYKIGYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLQGFLEEFADISKEDQiKKL 185
|
250
....*....|.
gi 24644932 676 NLLMKSLMLRR 686
Cdd:cd17994 186 HDLLGPHMLRR 196
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
437-686 |
7.50e-13 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 69.31 E-value: 7.50e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 437 VSLMNHQKHALAWM--SWRERKlprGGILADDMGLGKTLTMISSVLACKNGQEMSegkdessdsdseddknkkrksvtgw 514
Cdd:cd18053 19 LELRDYQLNGLNWLahSWCKGN---SCILADEMGLGKTIQTISFLNYLFHEHQLY------------------------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 515 kskgrkdtrrGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNRET---------KGKYLRdYDIVVTTYQIVARE 585
Cdd:cd18053 71 ----------GPFLLVVPLSTLTSWQREIQTWAPQMNAVVYLGDINSRNMirthewmhpQTKRLK-FNILLTTYEILLKD 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 586 HKSLSavfGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFddlHTWKKWID 665
Cdd:cd18053 140 KSFLG---GLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKF---SSWEDFEE 213
|
250 260
....*....|....*....|....
gi 24644932 666 NKSAG---GQNRLNLLMKSLMLRR 686
Cdd:cd18053 214 EHGKGreyGYASLHKELEPFLLRR 237
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
438-688 |
1.13e-12 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 69.32 E-value: 1.13e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 438 SLMNHQKHALAWM-SWRERKLprGGILADDMGLGKTLTMISSVLACKNGQEMSegkdessdsdseddknkkrksvtgwks 516
Cdd:cd18063 23 TLKHYQLQGLEWMvSLYNNNL--NGILADEMGLGKTIQTIALITYLMEHKRLN--------------------------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 517 kgrkdtrrGGTLVVCPASLLRQWESEVES------KVSRQKLTVCVHHGNNRETKGKYlrdyDIVVTTYQIVAREHKSLS 590
Cdd:cd18063 74 --------GPYLIIVPLSTLSNWTYEFDKwapsvvKISYKGTPAMRRSLVPQLRSGKF----NVLLTTYEYIIKDKHILA 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 591 AVfgvKWRRIILDEAHVVRNHKSQ-SSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNKSA 669
Cdd:cd18063 142 KI---RWKYMIVDEGHRMKNHHCKlTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFA 218
|
250 260 270
....*....|....*....|....*....|...
gi 24644932 670 GGQNRLNL--------------LMKSLMLRRTK 688
Cdd:cd18063 219 MTGERVDLneeetiliirrlhkVLRPFLLRRLK 251
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
439-686 |
3.51e-11 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 64.68 E-value: 3.51e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALAWM-SWRERKLprGGILADDMGLGKTLTMISSVLACKNGQEMSegkdessdsdseddknkkrksvtgwksk 517
Cdd:cd18062 24 LKQYQIKGLEWLvSLYNNNL--NGILADEMGLGKTIQTIALITYLMEHKRIN---------------------------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 518 grkdtrrGGTLVVCPASLLRQWESEVESKVSRqklTVCVHHGNNRETKGKYLR-----DYDIVVTTYQIVAREHKSLSAV 592
Cdd:cd18062 74 -------GPFLIIVPLSTLSNWVYEFDKWAPS---VVKVSYKGSPAARRAFVPqlrsgKFNVLLTTYEYIIKDKQILAKI 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 593 fgvKWRRIILDEAHVVRNHKSQ-SSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNKSA-- 669
Cdd:cd18062 144 ---RWKYMIVDEGHRMKNHHCKlTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAmt 220
|
250
....*....|....*..
gi 24644932 670 GGQNRLNLLMKSLMLRR 686
Cdd:cd18062 221 GEKVDLNEEETILIIRR 237
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
453-673 |
1.64e-10 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 62.49 E-value: 1.64e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 453 RERKLPRGGILADDMGLGKTL---TMISSVLackngQEMSEGKDESsdsdseddkNKkrksvtgwkskgrkdtrrggTLV 529
Cdd:cd18067 19 RRIRGSHGCIMADEMGLGKTLqciTLMWTLL-----RQSPQCKPEI---------DK--------------------AIV 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 530 VCPASLLRQWESEVESKVSRQKLTVCVHHGNNRETKGKYLRDYDI----VVTTYQIVAREHKSLSAVFGVKWR--RIILD 603
Cdd:cd18067 65 VSPSSLVKNWANELGKWLGGRLQPLAIDGGSKKEIDRKLVQWASQqgrrVSTPVLIISYETFRLHVEVLQKGEvgLVICD 144
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 604 EAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNKSAGGQN 673
Cdd:cd18067 145 EGHRLKNSDNQTYQALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNFELPILKGRD 214
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
428-634 |
7.72e-10 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 62.73 E-value: 7.72e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 428 LAEDPVGLKVSLMNHQKHAL-AWMSWRERKlPRGGILADDMGLGKTLTMISSVLACKNGQEmsegkdessdsdseddknk 506
Cdd:COG1061 70 AGDEASGTSFELRPYQQEALeALLAALERG-GGRGLVVAPTGTGKTVLALALAAELLRGKR------------------- 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 507 krksvtgwkskgrkdtrrggTLVVCP-ASLLRQWESEVeskvsRQKLTVCVHHGNNREtkgkylRDYDIVVTTYQIVAR- 584
Cdd:COG1061 130 --------------------VLVLVPrRELLEQWAEEL-----RRFLGDPLAGGGKKD------SDAPITVATYQSLARr 178
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 24644932 585 -EHKSLSAVFGVkwrrIILDEAHVVRnhkSQSSLAVCD-LRGKYRWALTGTP 634
Cdd:COG1061 179 aHLDELGDRFGL----VIIDEAHHAG---APSYRRILEaFPAAYRLGLTATP 223
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
442-634 |
9.22e-09 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 55.39 E-value: 9.22e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 442 HQKHALAwmSWRERKLPRGGILADDMGLGKTLTMISsvLACKngqemsegkdessdsdseddknkkrksvtgwkskgrkd 521
Cdd:cd17926 4 YQEEALE--AWLAHKNNRRGILVLPTGSGKTLTALA--LIAY-------------------------------------- 41
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 522 TRRGGTLVVCP-ASLLRQWESEVEskvsrqKLTVCVHHGNNRETKGKYLRDYDIVVTTYQIVAREHKSLSAVFGVKWrRI 600
Cdd:cd17926 42 LKELRTLIVVPtDALLDQWKERFE------DFLGDSSIGLIGGGKKKDFDDANVVVATYQSLSNLAEEEKDLFDQFG-LL 114
|
170 180 190
....*....|....*....|....*....|....*.
gi 24644932 601 ILDEAHvvrnHKSQSSLAVC--DLRGKYRWALTGTP 634
Cdd:cd17926 115 IVDEAH----HLPAKTFSEIlkELNAKYRLGLTATP 146
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
439-686 |
1.17e-08 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 57.00 E-value: 1.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALAWM--SWRERKlprGGILADDMGLGKTLTMISSVLAC-KNGQemSEGKDESSDSDSEDDKNKKRKSVtgWK 515
Cdd:cd18057 1 LHPYQLEGLNWLrfSWAQGT---DTILADEMGLGKTVQTIVFLYSLyKEGH--SKGPYLVSAPLSTIINWEREFEM--WA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 516 S-------KGRKDTRrggtlvvcpaSLLRQWESEVESKVSRQKLTVCvhhgnnRETKGKYLRdYDIVVTTYQIVAREHKS 588
Cdd:cd18057 74 PdfyvvtyTGDKESR----------SVIRENEFSFEDNAIRSGKKVF------RMKKEAQIK-FHVLLTSYELITIDQAI 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 589 LSAVfgvKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNKS 668
Cdd:cd18057 137 LGSI---EWACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADIS 213
|
250
....*....|....*....
gi 24644932 669 AGGQ-NRLNLLMKSLMLRR 686
Cdd:cd18057 214 KEDQiKKLHDLLGPHMLRR 232
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
442-686 |
1.20e-08 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 56.94 E-value: 1.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 442 HQKHALAWM--SWRERKlprGGILADDMGLGKTLTMISSVLACkngqeMSEGKDessdsdseddknkkrksvtgwkskgr 519
Cdd:cd18055 4 YQLEGLNWLrfSWAQGT---DTILADEMGLGKTIQTIVFLYSL-----YKEGHT-------------------------- 49
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 520 kdtrRGGTLVVCPASLLRQWESEVE-------------SKVSRQKLTVCVHHGNNRETKG-----KYLRD----YDIVVT 577
Cdd:cd18055 50 ----KGPFLVSAPLSTIINWEREFQmwapdfyvvtytgDKDSRAIIRENEFSFDDNAVKGgkkafKMKREaqvkFHVLLT 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 578 TYQIVAREHKSLSAVfgvKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDL 657
Cdd:cd18055 126 SYELVTIDQAALGSI---RWACLVVDEAHRLKNNQSKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNL 202
|
250 260 270
....*....|....*....|....*....|
gi 24644932 658 HTWKKWIDNKSAGGQ-NRLNLLMKSLMLRR 686
Cdd:cd18055 203 EGFLEEFADISKEDQiKKLHDLLGPHMLRR 232
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
439-650 |
8.02e-08 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 54.51 E-value: 8.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALAWMsW---------RERKLPRGGILADDMGLGKTLTMIS---SVLACKngqemsegkdessdsdseddKNK 506
Cdd:cd18068 1 LKPHQVDGVQFM-WdccceslkkTKKSPGSGCILAHCMGLGKTLQVVTflhTVLLCE--------------------KLE 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 507 KRKSVtgwkskgrkdtrrggtLVVCPASLLRQWESEVES--------------KVSRQKLTVCVHHGNNR--ETKGKYLR 570
Cdd:cd18068 60 NFSRV----------------LVVCPLNTVLNWLNEFEKwqeglkdeekievnELATYKRPQERSYKLQRwqEEGGVMII 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 571 DYDIvvttYQIVARE-----HKSLSAVFGVKWRR-----IILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKEL 640
Cdd:cd18068 124 GYDM----YRILAQErnvksREKLKEIFNKALVDpgpdfVVCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLI 199
|
250
....*....|
gi 24644932 641 DVYALLKFLR 650
Cdd:cd18068 200 EYHCMVNFVK 209
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
460-650 |
2.33e-07 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 52.90 E-value: 2.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 460 GGILADDMGLGKTLTMISSVlackngqemsegkdessdsdSEDDKNKKRKSVtgwkskgrkdtrrggtLVVCPASLLRQW 539
Cdd:cd18069 30 GCILAHSMGLGKTLQVISFL--------------------DVLLRHTGAKTV----------------LAIVPVNTLQNW 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 540 ESEVESKVSRQKLTVCVHhgnnretkgkyLRDYDIvvttyQIVAREHKSLSAVFGV--KWRR------------------ 599
Cdd:cd18069 74 LSEFNKWLPPPEALPNVR-----------PRPFKV-----FILNDEHKTTAARAKVieDWVKdggvllmgyemfrlrpgp 137
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 24644932 600 --IILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLR 650
Cdd:cd18069 138 dvVICDEGHRIKNCHASTSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFVR 190
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
441-649 |
3.67e-07 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 51.97 E-value: 3.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 441 NHQKHALAWMswreRKLPRGGILADdMGLGKTLTMISSVlackngqemsegkdessdsdseddknkkrksvtgwkSKGRK 520
Cdd:cd18013 3 PYQKVAINFI----IEHPYCGLFLD-MGLGKTVTTLTAL------------------------------------SDLQL 41
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 521 DTRRGGTLVVCPASLLRQ-WESEVESKVSRQKLTVCVHHGNNRETKGKYLRDYDIVVTTYQIVarehKSLSAVFGVKW-- 597
Cdd:cd18013 42 DDFTRRVLVIAPLRVARStWPDEVEKWNHLRNLTVSVAVGTERQRSKAANTPADLYVINRENL----KWLVNKSGDPWpf 117
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 24644932 598 RRIILDEAHVVRNHKSQSSLAVCDLRGKYRW--ALTGTPIQNKELDVYALLKFL 649
Cdd:cd18013 118 DMVVIDELSSFKSPRSKRFKALRKVRPVIKRliGLTGTPSPNGLMDLWAQIALL 171
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
439-686 |
2.35e-06 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 50.06 E-value: 2.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 439 LMNHQKHALAWM--SWRERKlprGGILADDMGLGKTLtmissvlackngqemsegkdessdsdseddknkkrKSVTGWKS 516
Cdd:cd18056 1 LHPYQLEGLNWLrfSWAQGT---DTILADEMGLGKTV-----------------------------------QTAVFLYS 42
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 517 KGRKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNR----------------------ETKGKYLRDYDI 574
Cdd:cd18056 43 LYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVTYVGDKDSRaiirenefsfednairggkkasRMKKEASVKFHV 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 575 VVTTYQIVAREHKSLSAVfgvKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPF 654
Cdd:cd18056 123 LLTSYELITIDMAILGSI---DWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERF 199
|
250 260 270
....*....|....*....|....*....|...
gi 24644932 655 DDLHTW-KKWIDNKSAGGQNRLNLLMKSLMLRR 686
Cdd:cd18056 200 HNLEGFlEEFADIAKEDQIKKLHDMLGPHMLRR 232
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
521-608 |
2.44e-06 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 48.17 E-value: 2.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 521 DTRRGGTLVVCP-ASLLRQWESEVeSKVSRQKLTVCVHHGNN--RETKGKYLRDYDIVVTTYQIVAREHKSLSAVFGVKW 597
Cdd:cd00046 27 LKKGKKVLVLVPtKALALQTAERL-RELFGPGIRVAVLVGGSsaEEREKNKLGDADIIIATPDMLLNLLLREDRLFLKDL 105
|
90
....*....|.
gi 24644932 598 RRIILDEAHVV 608
Cdd:cd00046 106 KLIIVDEAHAL 116
|
|
| DEXHc_XPB |
cd18029 |
DEXH-box helicase domain of TFIIH XPB subunit and similar proteins; TFIIH basal transcription ... |
527-608 |
2.69e-05 |
|
DEXH-box helicase domain of TFIIH XPB subunit and similar proteins; TFIIH basal transcription factor complex helicase XPB subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350787 [Multi-domain] Cd Length: 169 Bit Score: 45.76 E-value: 2.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 527 TLVVCPASL-LRQWESEVESKVSRQKLTVCVHHGNNRETkgkyLRDYDIVVTTYQIVAREHKS-------LSAVFGVKWR 598
Cdd:cd18029 54 TLVLCTSAVsVEQWRRQFLDWTTIDDEQIGRFTSDKKEI----FPEAGVTVSTYSMLANTRKRspesekfMEFITEREWG 129
|
90
....*....|
gi 24644932 599 RIILDEAHVV 608
Cdd:cd18029 130 LIILDEVHVV 139
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
527-637 |
3.90e-03 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 39.15 E-value: 3.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644932 527 TLVVCP-ASLLRQWESEVESKVSRQKLTV-CVHHGNNRETKGKYLRDYDIVVTTYQIVAREHKSLSAVFGVKWrrIILDE 604
Cdd:pfam00270 48 ALVLAPtRELAEQIYEELKKLGKGLGLKVaSLLGGDSRKEQLEKLKGPDILVGTPGRLLDLLQERKLLKNLKL--LVLDE 125
|
90 100 110
....*....|....*....|....*....|....*.
gi 24644932 605 AHVVRNHKSQSSLAVC--DLRGKYRW-ALTGTPIQN 637
Cdd:pfam00270 126 AHRLLDMGFGPDLEEIlrRLPKKRQIlLLSATLPRN 161
|
|
| |
