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Conserved domains on  [gi|61097900|ref|NP_543165|]
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cytokine receptor common subunit gamma precursor [Rattus norvegicus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10414115)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 154-246 1.29e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.03  E-value: 1.29e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61097900 154 PWAPENLTLYNLSESQVELRWK--SRYIERCLQYLVQYRSNRDRSWTEQIVDH--EPRFSLPSVDEQKLYTFRVRSRfnp 229
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVTLSWTppEDDGGPITGYVVEYREKGSGDWKEVEVTPgsETSYTLTGLKPGTEYEFRVRAV--- 77

                        90
                ....*....|....*..
gi 61097900 230 icgSTQQWSKWSQPIHW 246
Cdd:cd00063  78 ---NGGGESPPSESVTV 91
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 59-116 1.27e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam09240:

Pssm-ID: 473895  Cd Length: 96  Bit Score: 46.25  E-value: 1.27e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 61097900    59 EVQCFVFNVEYMNCTWNSSSEPQP-TNLTMHYRYKGSDNntFQECSHYLFSKEITSGCQ 116
Cdd:pfam09240   1 DLTCFIHNPSNLSCEWKPGPNAPPdTNYVLYVRKSPLGP--VLQCQYYIRDDGTRIGCQ 57
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 154-246 1.29e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.03  E-value: 1.29e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61097900 154 PWAPENLTLYNLSESQVELRWK--SRYIERCLQYLVQYRSNRDRSWTEQIVDH--EPRFSLPSVDEQKLYTFRVRSRfnp 229
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVTLSWTppEDDGGPITGYVVEYREKGSGDWKEVEVTPgsETSYTLTGLKPGTEYEFRVRAV--- 77

                        90
                ....*....|....*..
gi 61097900 230 icgSTQQWSKWSQPIHW 246
Cdd:cd00063  78 ---NGGGESPPSESVTV 91
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 59-116 1.27e-06

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 46.25  E-value: 1.27e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 61097900    59 EVQCFVFNVEYMNCTWNSSSEPQP-TNLTMHYRYKGSDNntFQECSHYLFSKEITSGCQ 116
Cdd:pfam09240   1 DLTCFIHNPSNLSCEWKPGPNAPPdTNYVLYVRKSPLGP--VLQCQYYIRDDGTRIGCQ 57
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 154-226 1.39e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 1.39e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 61097900    154 PWAPENLTLYNLSESQVELRWKSRYIERCLQYLVQYR---SNRDRSWTEQIVDH-EPRFSLPSVDEQKLYTFRVRSR 226
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRveyREEGSEWKEVNVTPsSTSYTLTGLKPGTEYEFRVRAV 77
fn3 pfam00041
Fibronectin type III domain;
156-241 4.52e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.55  E-value: 4.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61097900   156 APENLTLYNLSESQVELRWK-----SRYIERclqYLVQYRS-NRDRSWTEQIVD-HEPRFSLPSVDEQKLYTFRVRSRfn 228
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTpppdgNGPITG---YEVEYRPkNSGEPWNEITVPgTTTSVTLTGLKPGTEYEVRVQAV-- 76

                          90
                  ....*....|...
gi 61097900   229 picgSTQQWSKWS 241
Cdd:pfam00041  77 ----NGGGEGPPS 85
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 154-246 1.29e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.03  E-value: 1.29e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61097900 154 PWAPENLTLYNLSESQVELRWK--SRYIERCLQYLVQYRSNRDRSWTEQIVDH--EPRFSLPSVDEQKLYTFRVRSRfnp 229
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVTLSWTppEDDGGPITGYVVEYREKGSGDWKEVEVTPgsETSYTLTGLKPGTEYEFRVRAV--- 77

                        90
                ....*....|....*..
gi 61097900 230 icgSTQQWSKWSQPIHW 246
Cdd:cd00063  78 ---NGGGESPPSESVTV 91
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 59-116 1.27e-06

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 46.25  E-value: 1.27e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 61097900    59 EVQCFVFNVEYMNCTWNSSSEPQP-TNLTMHYRYKGSDNntFQECSHYLFSKEITSGCQ 116
Cdd:pfam09240   1 DLTCFIHNPSNLSCEWKPGPNAPPdTNYVLYVRKSPLGP--VLQCQYYIRDDGTRIGCQ 57
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 154-226 1.39e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 1.39e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 61097900    154 PWAPENLTLYNLSESQVELRWKSRYIERCLQYLVQYR---SNRDRSWTEQIVDH-EPRFSLPSVDEQKLYTFRVRSR 226
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRveyREEGSEWKEVNVTPsSTSYTLTGLKPGTEYEFRVRAV 77
fn3 pfam00041
Fibronectin type III domain;
156-241 4.52e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.55  E-value: 4.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61097900   156 APENLTLYNLSESQVELRWK-----SRYIERclqYLVQYRS-NRDRSWTEQIVD-HEPRFSLPSVDEQKLYTFRVRSRfn 228
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTpppdgNGPITG---YEVEYRPkNSGEPWNEITVPgTTTSVTLTGLKPGTEYEVRVQAV-- 76

                          90
                  ....*....|...
gi 61097900   229 picgSTQQWSKWS 241
Cdd:pfam00041  77 ----NGGGEGPPS 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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