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Conserved domains on  [gi|18390900|ref|NP_563818|]
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strictosidine synthase-like 3 [Arabidopsis thaliana]

Protein Classification

strictosidine synthase family protein( domain architecture ID 11465301)

strictosidine synthase family protein with similarity to strictosidine synthase that catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Str_synth super family cl22863
Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid ...
 179-266 1.98e-31

Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid biosynthesis. It catalyzes the condensation of tryptamine with secologanin to form strictosidine.


The actual alignment was detected with superfamily member pfam03088:

Pssm-ID: 354965 [Multi-domain]  Cd Length: 89  Bit Score: 114.46  E-value: 1.98e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900   179 NDLDIDDE-GNVYFTDSSSFFQRRKFMLLIVSGEDSGRVLKYNPKTKETTTLVRNLQFPNGLSLGKDGSFFIFCEGSIGR 257
Cdd:pfam03088   1 NALDVDPEtGVLYFTDSSSRYDRRQVIAAFLEGDATGRLMKYDPTTKVTKVLLDDLYFPNGIALSPDGSFVLFCETPMAR 80


                  ....*....
gi 18390900   258 LRKYWLKGE 266
Cdd:pfam03088  81 ISRYWIKEP 89
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 68-295 7.13e-29

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


:

Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 113.06  E-value: 7.13e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900  68 QGPESIAFDPQGRGPYTGVADGRILFWN--GTRWTDFAYTSnnrselcdpkpslldylkdedicGRPLGLRFDKkNGDLY 145
Cdd:COG3386   8 RLGEGPVWDPDGRLYWVDIPGGRIHRYDpdGGAVEVFAEPS-----------------------GRPNGLAFDP-DGRLL 63

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900 146 IADAYLGIMKVGPEGGLATSVTNEAdGVPLRFTNDLDIDDEGNVYFTDSSSFfqrrkfmllivsgEDSGRVLKYNPkTKE 225
Cdd:COG3386  64 VADHGRGLVRFDPADGEVTVLADEY-GKPLNRPNDGVVDPDGRLYFTDMGEY-------------LPTGALYRVDP-DGS 128

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18390900 226 TTTLVRNLQFPNGLSLGKDGSFFIFCEGSIGRLRKYWLKGE-KAGTSEVVALLH---GFPDNIRTNKDGDFWVA 295
Cdd:COG3386 129 LRVLADGLTFPNGIAFSPDGRTLYVADTGAGRIYRFDLDADgTLGNRRVFADLPdgpGGPDGLAVDADGNLWVA 202
 
Name Accession Description Interval E-value
Str_synth pfam03088
Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid ...
 179-266 1.98e-31

Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid biosynthesis. It catalyzes the condensation of tryptamine with secologanin to form strictosidine.


Pssm-ID: 281131 [Multi-domain]  Cd Length: 89  Bit Score: 114.46  E-value: 1.98e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900   179 NDLDIDDE-GNVYFTDSSSFFQRRKFMLLIVSGEDSGRVLKYNPKTKETTTLVRNLQFPNGLSLGKDGSFFIFCEGSIGR 257
Cdd:pfam03088   1 NALDVDPEtGVLYFTDSSSRYDRRQVIAAFLEGDATGRLMKYDPTTKVTKVLLDDLYFPNGIALSPDGSFVLFCETPMAR 80


                  ....*....
gi 18390900   258 LRKYWLKGE 266
Cdd:pfam03088  81 ISRYWIKEP 89
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 68-295 7.13e-29

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 113.06  E-value: 7.13e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900  68 QGPESIAFDPQGRGPYTGVADGRILFWN--GTRWTDFAYTSnnrselcdpkpslldylkdedicGRPLGLRFDKkNGDLY 145
Cdd:COG3386   8 RLGEGPVWDPDGRLYWVDIPGGRIHRYDpdGGAVEVFAEPS-----------------------GRPNGLAFDP-DGRLL 63

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900 146 IADAYLGIMKVGPEGGLATSVTNEAdGVPLRFTNDLDIDDEGNVYFTDSSSFfqrrkfmllivsgEDSGRVLKYNPkTKE 225
Cdd:COG3386  64 VADHGRGLVRFDPADGEVTVLADEY-GKPLNRPNDGVVDPDGRLYFTDMGEY-------------LPTGALYRVDP-DGS 128

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18390900 226 TTTLVRNLQFPNGLSLGKDGSFFIFCEGSIGRLRKYWLKGE-KAGTSEVVALLH---GFPDNIRTNKDGDFWVA 295
Cdd:COG3386 129 LRVLADGLTFPNGIAFSPDGRTLYVADTGAGRIYRFDLDADgTLGNRRVFADLPdgpGGPDGLAVDADGNLWVA 202
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 69-295 1.87e-09

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 58.10  E-value: 1.87e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900  69 GPESIAFDPQGRgPYtgVAD---GRILFWN--GTRWTDFAYTSNNRSELCDPKpslldylkdedicgrplGLRFDKkNGD 143
Cdd:cd05819  56 EPAGVAVDSDGN-LY--VADtgnHRIQKFDpdGNFLASFGGSGDGDGEFNGPR-----------------GIAVDS-SGN 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900 144 LYIADAYLG-IMKVGPEGGLATSVTNEADGV-PLRFTNDLDIDDEGNVYFTDSssffqrrkfmllivsgeDSGRVLKYNP 221
Cdd:cd05819 115 IYVADTGNHrIQKFDPDGEFLTTFGSGGSGPgQFNGPTGVAVDSDGNIYVADT-----------------GNHRIQVFDP 177

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900 222 KTK------ETTTLVRNLQFPNGLSLGKDGSFFIfCEGSIGRLRKYWLKGE---KAGTSEVVALLHGFPDNIRTNKDGDF 292
Cdd:cd05819 178 DGNflttfgSTGTGPGQFNYPTGIAVDSDGNIYV-ADSGNNRVQVFDPDGAgfgGNGNFLGSDGQFNRPSGLAVDSDGNL 256


                ...
gi 18390900 293 WVA 295
Cdd:cd05819 257 YVA 259
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
129-295 4.52e-08

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 53.87  E-value: 4.52e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900 129 CGRPLGLRFDKkNGDLYIADAYLG-IMKVGPEGGLATSVTNEADGVPLrftnDLDIDDEGNVYFTDSSsffqrrkfmlli 207
Cdd:COG4257  16 GSGPRDVAVDP-DGAVWFTDQGGGrIGRLDPATGEFTEYPLGGGSGPH----GIAVDPDGNLWFTDNG------------ 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900 208 vsgedSGRVLKYNPKTKETTTLV--RNLQFPNGLSLGKDGSFFiFCEGSIGRLRKYWLKGEKAgTSEVVALLHGFPDNIR 285
Cdd:COG4257  79 -----NNRIGRIDPKTGEITTFAlpGGGSNPHGIAFDPDGNLW-FTDQGGNRIGRLDPATGEV-TEFPLPTGGAGPYGIA 151

                       170
                ....*....|
gi 18390900 286 TNKDGDFWVA 295
Cdd:COG4257 152 VDPDGNLWVT 161
SSL_N pfam20067
Strictosidine synthase-like, N-terminal; This domain is found at the N-terminal of ...
 54-94 2.94e-06

Strictosidine synthase-like, N-terminal; This domain is found at the N-terminal of strictosidine synthase-like (SSL) proteins including Adipocyte plasma membrane- associated proteins (APMAPs) from animals, Protein STRICTOSIDINE SYNTHASE-LIKE (SSLs) from Arabidopsis and SGL proteins, being also present in bacterial sequences. It is about 50 amino acids in length. It contains residues involved in metal coordination in the active site. This domain is also found in Gluconolactonase and Sugar lactone lactonase. These proteins share a six-bladed beta-propeller fold structure and have similar structural and mechanistic features to SS (strictosidine synthase) that involve nucleophilic attack on an electrophilic substrate, although they do not catalyze the SS reaction as they lack the catalytic glutamate required for SS activity; they catalyze hydrolytic reactions instead. APMAPs shows similarity with paraoxonases (PON) and has a strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. They are involved in adipocyte differentiation.


Pssm-ID: 437899 [Multi-domain]  Cd Length: 46  Bit Score: 43.63  E-value: 2.94e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 18390900    54 NLLQNSEIRFLNEVQGPESIAFDPQGRgPYTGVADGRILFW 94
Cdd:pfam20067   7 DRLAGAELIALGGEHGPEDIAVDPDGR-LYTGLHDGRIVRM 46
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 131-295 2.00e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 45.77  E-value: 2.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900 131 RPLGLRFDKkNGDLYIADAYLG-IMKVGPEGGLATSVTNEADG-VPLRFTNDLDIDDEGNVYFTDSssffqrrkfmlliv 208
Cdd:cd05819   9 NPQGIAVDS-SGNIYVADTGNNrIQVFDPDGNFITSFGSFGSGdGQFNEPAGVAVDSDGNLYVADT-------------- 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900 209 sgeDSGRVLKYNPKTKETTTLVRN------LQFPNGLSLGKDGSFFIfCEGSIGRLRKYWLKGE---KAGTSEVVALLHG 279
Cdd:cd05819  74 ---GNHRIQKFDPDGNFLASFGGSgdgdgeFNGPRGIAVDSSGNIYV-ADTGNHRIQKFDPDGEfltTFGSGGSGPGQFN 149

                       170
                ....*....|....*.
gi 18390900 280 FPDNIRTNKDGDFWVA 295
Cdd:cd05819 150 GPTGVAVDSDGNIYVA 165
 
Name Accession Description Interval E-value
Str_synth pfam03088
Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid ...
 179-266 1.98e-31

Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid biosynthesis. It catalyzes the condensation of tryptamine with secologanin to form strictosidine.


Pssm-ID: 281131 [Multi-domain]  Cd Length: 89  Bit Score: 114.46  E-value: 1.98e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900   179 NDLDIDDE-GNVYFTDSSSFFQRRKFMLLIVSGEDSGRVLKYNPKTKETTTLVRNLQFPNGLSLGKDGSFFIFCEGSIGR 257
Cdd:pfam03088   1 NALDVDPEtGVLYFTDSSSRYDRRQVIAAFLEGDATGRLMKYDPTTKVTKVLLDDLYFPNGIALSPDGSFVLFCETPMAR 80


                  ....*....
gi 18390900   258 LRKYWLKGE 266
Cdd:pfam03088  81 ISRYWIKEP 89
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 68-295 7.13e-29

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 113.06  E-value: 7.13e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900  68 QGPESIAFDPQGRGPYTGVADGRILFWN--GTRWTDFAYTSnnrselcdpkpslldylkdedicGRPLGLRFDKkNGDLY 145
Cdd:COG3386   8 RLGEGPVWDPDGRLYWVDIPGGRIHRYDpdGGAVEVFAEPS-----------------------GRPNGLAFDP-DGRLL 63

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900 146 IADAYLGIMKVGPEGGLATSVTNEAdGVPLRFTNDLDIDDEGNVYFTDSSSFfqrrkfmllivsgEDSGRVLKYNPkTKE 225
Cdd:COG3386  64 VADHGRGLVRFDPADGEVTVLADEY-GKPLNRPNDGVVDPDGRLYFTDMGEY-------------LPTGALYRVDP-DGS 128

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18390900 226 TTTLVRNLQFPNGLSLGKDGSFFIFCEGSIGRLRKYWLKGE-KAGTSEVVALLH---GFPDNIRTNKDGDFWVA 295
Cdd:COG3386 129 LRVLADGLTFPNGIAFSPDGRTLYVADTGAGRIYRFDLDADgTLGNRRVFADLPdgpGGPDGLAVDADGNLWVA 202
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
69-297 3.71e-11

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 63.11  E-value: 3.71e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900  69 GPESIAFDPQGRGPYTGVADGRILFWNGT--RWTDFAYTSNNR-SELC-DPKPSL------------LDYlKDEDI---- 128
Cdd:COG4257  18 GPRDVAVDPDGAVWFTDQGGGRIGRLDPAtgEFTEYPLGGGSGpHGIAvDPDGNLwftdngnnrigrIDP-KTGEIttfa 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900 129 ----CGRPLGLRFDKkNGDLYIADAYLG-IMKVGPEGGlatSVTNEADGVPLRFTNDLDIDDEGNVYFTDSSSffqrrkf 203
Cdd:COG4257  97 lpggGSNPHGIAFDP-DGNLWFTDQGGNrIGRLDPATG---EVTEFPLPTGGAGPYGIAVDPDGNLWVTDFGA------- 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900 204 mllivsgedsGRVLKYNPKTKETTT--LVRNLQFPNGLSLGKDGSFFIFCEGSiGRLRKYwlkGEKAGTSEVVAL--LHG 279
Cdd:COG4257 166 ----------NAIGRIDPDTGTLTEyaLPTPGAGPRGLAVDPDGNLWVADTGS-GRIGRF---DPKTGTVTEYPLpgGGA 231

                       250
                ....*....|....*...
gi 18390900 280 FPDNIRTNKDGDFWVAVH 297
Cdd:COG4257 232 RPYGVAVDGDGRVWFAES 249
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 69-295 1.87e-09

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 58.10  E-value: 1.87e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900  69 GPESIAFDPQGRgPYtgVAD---GRILFWN--GTRWTDFAYTSNNRSELCDPKpslldylkdedicgrplGLRFDKkNGD 143
Cdd:cd05819  56 EPAGVAVDSDGN-LY--VADtgnHRIQKFDpdGNFLASFGGSGDGDGEFNGPR-----------------GIAVDS-SGN 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900 144 LYIADAYLG-IMKVGPEGGLATSVTNEADGV-PLRFTNDLDIDDEGNVYFTDSssffqrrkfmllivsgeDSGRVLKYNP 221
Cdd:cd05819 115 IYVADTGNHrIQKFDPDGEFLTTFGSGGSGPgQFNGPTGVAVDSDGNIYVADT-----------------GNHRIQVFDP 177

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900 222 KTK------ETTTLVRNLQFPNGLSLGKDGSFFIfCEGSIGRLRKYWLKGE---KAGTSEVVALLHGFPDNIRTNKDGDF 292
Cdd:cd05819 178 DGNflttfgSTGTGPGQFNYPTGIAVDSDGNIYV-ADSGNNRVQVFDPDGAgfgGNGNFLGSDGQFNRPSGLAVDSDGNL 256


                ...
gi 18390900 293 WVA 295
Cdd:cd05819 257 YVA 259
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
129-295 4.52e-08

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 53.87  E-value: 4.52e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900 129 CGRPLGLRFDKkNGDLYIADAYLG-IMKVGPEGGLATSVTNEADGVPLrftnDLDIDDEGNVYFTDSSsffqrrkfmlli 207
Cdd:COG4257  16 GSGPRDVAVDP-DGAVWFTDQGGGrIGRLDPATGEFTEYPLGGGSGPH----GIAVDPDGNLWFTDNG------------ 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900 208 vsgedSGRVLKYNPKTKETTTLV--RNLQFPNGLSLGKDGSFFiFCEGSIGRLRKYWLKGEKAgTSEVVALLHGFPDNIR 285
Cdd:COG4257  79 -----NNRIGRIDPKTGEITTFAlpGGGSNPHGIAFDPDGNLW-FTDQGGNRIGRLDPATGEV-TEFPLPTGGAGPYGIA 151

                       170
                ....*....|
gi 18390900 286 TNKDGDFWVA 295
Cdd:COG4257 152 VDPDGNLWVT 161
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 132-297 1.07e-07

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 52.26  E-value: 1.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900   132 PLGLRFDKKNGDLYIADAY-LGIMKVgPEGGLATSVTNEADGVP-LRFtNDLDIDDEGNVYFTDSSSFfqrrkfmllIVS 209
Cdd:pfam08450  42 PVGAIAPRDDGGLIVALKDgVALLDL-ATGELTPLADPEDDDWPlNRF-NDGKVDPDGRFWFGTMGDD---------EAP 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900   210 GEDSGRVLKYNPKTKeTTTLVRNLQFPNGLSLGKDGSFFIFCEGSIGRLRKY--WLKGEKAGTSEVVALL---HGFPDNI 284
Cdd:pfam08450 111 GGDPGALYRLDPDGK-LTRVLDGLTISNGLAWSPDGRTLYFADSPARKIWAYdyDLDGGLISNRRVFADFkpgLGRPDGM 189

                         170
                  ....*....|...
gi 18390900   285 RTNKDGDFWVAVH 297
Cdd:pfam08450 190 AVDAEGNVWVARW 202
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
66-266 1.03e-06

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 49.63  E-value: 1.03e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900  66 EVQGPESIAFDPQGRGPYTGVADGRILF---WNGTRWTDFAYTSNnrselcdpkpslldylkdedicGRPLGLRFDKkNG 142
Cdd:COG4257 100 GGSNPHGIAFDPDGNLWFTDQGGNRIGRldpATGEVTEFPLPTGG----------------------AGPYGIAVDP-DG 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900 143 DLYIADAYLG-IMKVGPEGGLATSVTNEAdgvPLRFTNDLDIDDEGNVYFTDSssffqrrkfmllivsgeDSGRVLKYNP 221
Cdd:COG4257 157 NLWVTDFGANaIGRIDPDTGTLTEYALPT---PGAGPRGLAVDPDGNLWVADT-----------------GSGRIGRFDP 216

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 18390900 222 KTKETTTLVR--NLQFPNGLSLGKDGSFFiFCEGSIGRLRKYWLKGE 266
Cdd:COG4257 217 KTGTVTEYPLpgGGARPYGVAVDGDGRVW-FAESGANRIVRFDPDTE 262
SSL_N pfam20067
Strictosidine synthase-like, N-terminal; This domain is found at the N-terminal of ...
 54-94 2.94e-06

Strictosidine synthase-like, N-terminal; This domain is found at the N-terminal of strictosidine synthase-like (SSL) proteins including Adipocyte plasma membrane- associated proteins (APMAPs) from animals, Protein STRICTOSIDINE SYNTHASE-LIKE (SSLs) from Arabidopsis and SGL proteins, being also present in bacterial sequences. It is about 50 amino acids in length. It contains residues involved in metal coordination in the active site. This domain is also found in Gluconolactonase and Sugar lactone lactonase. These proteins share a six-bladed beta-propeller fold structure and have similar structural and mechanistic features to SS (strictosidine synthase) that involve nucleophilic attack on an electrophilic substrate, although they do not catalyze the SS reaction as they lack the catalytic glutamate required for SS activity; they catalyze hydrolytic reactions instead. APMAPs shows similarity with paraoxonases (PON) and has a strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. They are involved in adipocyte differentiation.


Pssm-ID: 437899 [Multi-domain]  Cd Length: 46  Bit Score: 43.63  E-value: 2.94e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 18390900    54 NLLQNSEIRFLNEVQGPESIAFDPQGRgPYTGVADGRILFW 94
Cdd:pfam20067   7 DRLAGAELIALGGEHGPEDIAVDPDGR-LYTGLHDGRIVRM 46
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 131-295 2.00e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 45.77  E-value: 2.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900 131 RPLGLRFDKkNGDLYIADAYLG-IMKVGPEGGLATSVTNEADG-VPLRFTNDLDIDDEGNVYFTDSssffqrrkfmlliv 208
Cdd:cd05819   9 NPQGIAVDS-SGNIYVADTGNNrIQVFDPDGNFITSFGSFGSGdGQFNEPAGVAVDSDGNLYVADT-------------- 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900 209 sgeDSGRVLKYNPKTKETTTLVRN------LQFPNGLSLGKDGSFFIfCEGSIGRLRKYWLKGE---KAGTSEVVALLHG 279
Cdd:cd05819  74 ---GNHRIQKFDPDGNFLASFGGSgdgdgeFNGPRGIAVDSSGNIYV-ADTGNHRIQKFDPDGEfltTFGSGGSGPGQFN 149

                       170
                ....*....|....*.
gi 18390900 280 FPDNIRTNKDGDFWVA 295
Cdd:cd05819 150 GPTGVAVDSDGNIYVA 165
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 130-197 7.10e-05

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 44.44  E-value: 7.10e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18390900 130 GRPLGLRFDKkNGDLYIADAYLG-IMKVGPEG------GLATSVTNEAD-GVPLRFTN--DLDIDDEGNVYFTDSSSF 197
Cdd:cd14953 242 NNPTGVAVDA-AGNLYVADSGNHrIRKITPAGvvttvaGGGAGFSGDGGpATSAQFNNptGVAVDAAGNLYVADTGNN 318
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 131-249 9.11e-05

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 44.06  E-value: 9.11e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900 131 RPLGLRFDKkNGDLYIADAYLG-IMKVGPEG---GLATSVTNE--ADGVPL--RFTN--DLDIDDEGNVYFTDSSsffqr 200
Cdd:cd14953 188 NPTGVAVDA-AGNLYVADRGNHrIRKITPDGvvtTVAGTGTAGfsGDGGATaaQLNNptGVAVDAAGNLYVADSG----- 261

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18390900 201 rkfmllivsgedSGRVLKYNPKTKETTTLVR--------------NLQFPNGLSLGKDGSFFI 249
Cdd:cd14953 262 ------------NHRIRKITPAGVVTTVAGGgagfsgdggpatsaQFNNPTGVAVDAAGNLYV 312
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
174-296 1.37e-04

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 43.08  E-value: 1.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900 174 PLRFTNDLDIDDEGNVYFTDSSsffqrrkfmllivsgedSGRVLKYNPKTKETTTLVRN-LQFPNGLSLGKDGSFFIFCE 252
Cdd:COG4257  15 PGSGPRDVAVDPDGAVWFTDQG-----------------GGRIGRLDPATGEFTEYPLGgGSGPHGIAVDPDGNLWFTDN 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 18390900 253 --GSIGRLRKywlkgeKAGTSEVVAL--LHGFPDNIRTNKDGDFWVAV 296
Cdd:COG4257  78 gnNRIGRIDP------KTGEITTFALpgGGSNPHGIAFDPDGNLWFTD 119
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 68-195 4.30e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 41.54  E-value: 4.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900  68 QGPESIAFDPQGRgPYtgVAD---GRILFWN--GTRWTDFAYTSNNRSELcdpkpslldylkdedicGRPLGLRFDKkNG 142
Cdd:cd05819 149 NGPTGVAVDSDGN-IY--VADtgnHRIQVFDpdGNFLTTFGSTGTGPGQF-----------------NYPTGIAVDS-DG 207

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 18390900 143 DLYIADAYLG-IMKVGPEGGLATSV-TNEADGVPLRFTNDLDIDDEGNVYFTDSS 195
Cdd:cd05819 208 NIYVADSGNNrVQVFDPDGAGFGGNgNFLGSDGQFNRPSGLAVDSDGNLYVADTG 262
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 140-245 1.82e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 39.58  E-value: 1.82e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900 140 KNGDLYIADAYLGIMKV-GPEGGLATSVTNEADGVPLRFTNDLDIDDeGNVYFTDSSSFFqrrkfmllIVSGEDSGRVLK 218
Cdd:cd14963  65 SDGNIYVADLYNGRIQVfDPDGKFLKYFPEKKDRVKLISPAGLAIDD-GKLYVSDVKKHK--------VIVFDLEGKLLL 135

                        90       100
                ....*....|....*....|....*....
gi 18390900 219 Y--NPKTKETttlvrNLQFPNGLSLGKDG 245
Cdd:cd14963 136 EfgKPGSEPG-----ELSYPNGIAVDEDG 159
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 130-302 2.89e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 39.11  E-value: 2.89e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900 130 GRPLGLRFDKkNGDLYIADaYLGIMKVGPEGGLATSVT------NEADGVPlrftndldIDDEGNVYFTDSssffqrrkf 203
Cdd:cd14952  94 NDPTGVAVDA-AGNVYVAD-TGNNRVLKLAAGSNTQTVlpftglSNPDGVA--------VDGAGNVYVTDT--------- 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900 204 mllivsgeDSGRVLKYNPKTKETTTL-VRNLQFPNGLSLGKDGSFFIfCEGSIGRLRKYwlkgeKAGTSEVVAL----LH 278
Cdd:cd14952 155 --------GNNRVLKLAAGSTTQTVLpFTGLNSPSGVAVDTAGNVYV-TDHGNNRVLKL-----AAGSTTPTVLpftgLN 220

                       170       180
                ....*....|....*....|....
gi 18390900 279 GfPDNIRTNKDGDFWVAVHCHRNI 302
Cdd:cd14952 221 G-PLGVAVDAAGNVYVADRGNDRV 243
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 66-195 6.16e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 38.04  E-value: 6.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390900  66 EVQGPESIAFDPQGRgPYtgVADgrilfwngtrwtdfayTSNNRSELCDPKPSLLDYLKDEDICGR----PLGLRFDKKn 141
Cdd:cd14963 146 ELSYPNGIAVDEDGN-IY--VAD----------------SGNGRIQVFDKNGKFIKELNGSPDGKSgfvnPRGIAVDPD- 205

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 18390900 142 GDLYIADAYLGIMKVGPEGG--LATSVTNEADGVPLRFTNDLDIDDEGNVYFTDSS 195
Cdd:cd14963 206 GNLYVVDNLSHRVYVFDEQGkeLFTFGGRGKDDGQFNLPNGLFIDDDGRLYVTDRE 261
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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