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Conserved domains on  [gi|30684506|ref|NP_563980|]
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Leucine-rich repeat family protein [Arabidopsis thaliana]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
148-559 1.09e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 1.09e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 148 SDITDSGLVSLKGCTNLESLNFNFCDQISNRGLVHLSGLSNLTSLSFRRNAAITAQGMRALSNLVNLKKLDLEKCPGIDG 227
Cdd:COG4886   8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 228 GLVHLRALTKLESLNIkwcncitdADMEPLSVLTNLRSLQICCSKITDIGISylkglnklnllnlegcrhvtaacldtLT 307
Cdd:COG4886  88 GLTDLGDLTNLTELDL--------SGNEELSNLTNLESLDLSGNQLTDLPEE--------------------------LA 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 308 ALAGLMYLNLNRCNFSDSGcEKFSDLINLKILNLGMNNITnSCLVHLKGLTKLESLNLDSCRIGDEGLVhLSGMLELKSL 387
Cdd:COG4886 134 NLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLT-DLPEELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEEL 210

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 388 ELSDTEVGSNGLrHLSGLSNLESINLSFTVVTDsgLRKLSGLTSLRTLNLDARHVTDagLSALTSLTGLTHLDLFGARIT 467
Cdd:COG4886 211 DLSGNQLTDLPE-PLANLTNLETLDLSNNQLTD--LPELGNLTNLEELDLSNNQLTD--LPPLANLTNLKTLDLSNNQLT 285

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 468 DSGTNHLRNLKKLQSLEICGGGLTDTGVKNIKDLSSLTLLNLSQNSNLTDKTLELISGLTGLVSLNVSNSRVSSSGLRHL 547
Cdd:COG4886 286 DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTL 365

                       410
                ....*....|..
gi 30684506 548 KPLKNLRSLTLE 559
Cdd:COG4886 366 LLTLGLLGLLEA 377
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
148-559 1.09e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 1.09e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 148 SDITDSGLVSLKGCTNLESLNFNFCDQISNRGLVHLSGLSNLTSLSFRRNAAITAQGMRALSNLVNLKKLDLEKCPGIDG 227
Cdd:COG4886   8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 228 GLVHLRALTKLESLNIkwcncitdADMEPLSVLTNLRSLQICCSKITDIGISylkglnklnllnlegcrhvtaacldtLT 307
Cdd:COG4886  88 GLTDLGDLTNLTELDL--------SGNEELSNLTNLESLDLSGNQLTDLPEE--------------------------LA 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 308 ALAGLMYLNLNRCNFSDSGcEKFSDLINLKILNLGMNNITnSCLVHLKGLTKLESLNLDSCRIGDEGLVhLSGMLELKSL 387
Cdd:COG4886 134 NLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLT-DLPEELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEEL 210

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 388 ELSDTEVGSNGLrHLSGLSNLESINLSFTVVTDsgLRKLSGLTSLRTLNLDARHVTDagLSALTSLTGLTHLDLFGARIT 467
Cdd:COG4886 211 DLSGNQLTDLPE-PLANLTNLETLDLSNNQLTD--LPELGNLTNLEELDLSNNQLTD--LPPLANLTNLKTLDLSNNQLT 285

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 468 DSGTNHLRNLKKLQSLEICGGGLTDTGVKNIKDLSSLTLLNLSQNSNLTDKTLELISGLTGLVSLNVSNSRVSSSGLRHL 547
Cdd:COG4886 286 DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTL 365

                       410
                ....*....|..
gi 30684506 548 KPLKNLRSLTLE 559
Cdd:COG4886 366 LLTLGLLGLLEA 377
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 298-470 6.65e-12

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 67.00  E-value: 6.65e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 298 VTAACLDTLTALAGLMYLNLNRCNFSDSGCEKFSDL---INLKILNLGMNNITNSCLVHL-KGLT----KLESLNLDSCR 369
Cdd:cd00116  69 GLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDRGLRLLaKGLKdlppALEKLVLGRNR 148

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 370 IGDEGLVHLSGML----ELKSLELSDTEVGSNGLRHL----SGLSNLESINLSFTVVTDSGLRKLSG----LTSLRTLNL 437
Cdd:cd00116 149 LEGASCEALAKALranrDLKELNLANNGIGDAGIRALaeglKANCNLEVLDLNNNGLTDEGASALAEtlasLKSLEVLNL 228

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 30684506 438 DARHVTDAGLSALTS-----LTGLTHLDLFGARITDSG 470
Cdd:cd00116 229 GDNNLTDAGAAALASallspNISLLTLSLSCNDITDDG 266
LRR_8 pfam13855
Leucine rich repeat;
311-370 2.71e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 2.71e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506   311 GLMYLNLNRCNFSDSGCEKFSDLINLKILNLGMNNITNSCLVHLKGLTKLESLNLDSCRI 370
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 304-485 9.18e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 9.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506  304 DTLTALAGLMYLNLNRCNFSDSGCEKFsdLINLKILNLGMNNITNSCLVHLKGLTKLESLNLDSCRIGDEGLVHLSGMLE 383
Cdd:PLN00113 112 DIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTS 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506  384 LKSLELSDTEVGSNGLRHLSGLSNLESINLSFTVVTDSGLRKLSGLTSLRTLNLDARHVTDAGLSALTSLTGLTHLDLFG 463
Cdd:PLN00113 190 LEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQ 269

                        170       180
                 ....*....|....*....|..
gi 30684506  464 ARITDSGTNHLRNLKKLQSLEI 485
Cdd:PLN00113 270 NKLSGPIPPSIFSLQKLISLDL 291
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
148-559 1.09e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 1.09e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 148 SDITDSGLVSLKGCTNLESLNFNFCDQISNRGLVHLSGLSNLTSLSFRRNAAITAQGMRALSNLVNLKKLDLEKCPGIDG 227
Cdd:COG4886   8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 228 GLVHLRALTKLESLNIkwcncitdADMEPLSVLTNLRSLQICCSKITDIGISylkglnklnllnlegcrhvtaacldtLT 307
Cdd:COG4886  88 GLTDLGDLTNLTELDL--------SGNEELSNLTNLESLDLSGNQLTDLPEE--------------------------LA 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 308 ALAGLMYLNLNRCNFSDSGcEKFSDLINLKILNLGMNNITnSCLVHLKGLTKLESLNLDSCRIGDEGLVhLSGMLELKSL 387
Cdd:COG4886 134 NLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLT-DLPEELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEEL 210

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 388 ELSDTEVGSNGLrHLSGLSNLESINLSFTVVTDsgLRKLSGLTSLRTLNLDARHVTDagLSALTSLTGLTHLDLFGARIT 467
Cdd:COG4886 211 DLSGNQLTDLPE-PLANLTNLETLDLSNNQLTD--LPELGNLTNLEELDLSNNQLTD--LPPLANLTNLKTLDLSNNQLT 285

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 468 DSGTNHLRNLKKLQSLEICGGGLTDTGVKNIKDLSSLTLLNLSQNSNLTDKTLELISGLTGLVSLNVSNSRVSSSGLRHL 547
Cdd:COG4886 286 DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTL 365

                       410
                ....*....|..
gi 30684506 548 KPLKNLRSLTLE 559
Cdd:COG4886 366 LLTLGLLGLLEA 377
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
293-579 8.27e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.59  E-value: 8.27e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 293 EGCRHVTAACLDTLTALAGLMYLNLNRCNFSDSGcEKFSDLINLKILNLGMNNITNSCLVhLKGLTKLESLNLDSCRIGD 372
Cdd:COG4886  96 TNLTELDLSGNEELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTD 173

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 373 EGlVHLSGMLELKSLELSDTEVgSNGLRHLSGLSNLESINLSFTVVTDSGLrKLSGLTSLRTLNLDARHVTDagLSALTS 452
Cdd:COG4886 174 LP-EELGNLTNLKELDLSNNQI-TDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTD--LPELGN 248

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 453 LTGLTHLDLFGARITDSGtnHLRNLKKLQSLEICGGGLTDTGVKNIKDLSSLTLLNLSQNSNLTDKTLELISGLTGLVSL 532
Cdd:COG4886 249 LTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLL 326

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 30684506 533 NVSNSRVSSSGLRHLKPLKNLRSLTLESCKLSANDIRKLQATDLPNL 579
Cdd:COG4886 327 LLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 277-500 1.07e-14

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 76.37  E-value: 1.07e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 277 GISYLKGLNKLNLLNLEGCRHVTAACLDTLTALAGLMYLNLnrcnfSDSGCEKFSDLI----NLKILNLGMNNITNSCLV 352
Cdd:COG5238 152 GGNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQI-----GDEGIEELAEALtqntTVTTLWLKRNPIGDEGAE 226

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 353 ----HLKGLTKLESLNLDSCRIGDEGLVHLSGMLE----LKSLELSDTEVGSNGLR----HLSGLSNLESINLSFTVVTD 420
Cdd:COG5238 227 ilaeALKGNKSLTTLDLSNNQIGDEGVIALAEALKnnttVETLYLSGNQIGAEGAIalakALQGNTTLTSLDLSVNRIGD 306

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 421 SGLRK----LSGLTSLRTLNLDARHVTDAG----LSALTSLTGLTHLDLFGARITDSGT----NHLRNLKKLQSLEICGG 488
Cdd:COG5238 307 EGAIAlaegLQGNKTLHTLNLAYNGIGAQGaialAKALQENTTLHSLDLSDNQIGDEGAialaKYLEGNTTLRELNLGKN 386

                       250
                ....*....|..
gi 30684506 489 GLTDTGVKNIKD 500
Cdd:COG5238 387 NIGKQGAEALID 398
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
94-529 2.75e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.97  E-value: 2.75e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506  94 ELVYSQRLTLKSLEAFRDCAIQDLYLGEYPGVNDDWMDVISSQSTSLLSVDFSGSDITDSGLVSLKGCTNLESLNFNFCD 173
Cdd:COG4886   3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 174 QISNRGLVHLSGLSNLTSLSFRRNaaitaqgmRALSNLVNLKKLDLEKCPGIDGGlVHLRALTKLESLNIkWCNCITDAD 253
Cdd:COG4886  83 SLLLLGLTDLGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDL-SNNQLTDLP 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 254 mEPLSVLTNLRSLQICCSKITDIGISylkglnklnllnlegcrhvtaacldtLTALAGLMYLNLNRCNFSDSGCEkFSDL 333
Cdd:COG4886 153 -EPLGNLTNLKSLDLSNNQLTDLPEE--------------------------LGNLTNLKELDLSNNQITDLPEP-LGNL 204

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 334 INLKILNLGMNNITNscL-VHLKGLTKLESLNLDSCRIGDegLVHLSGMLELKSLELSDTEVGSngLRHLSGLSNLESIN 412
Cdd:COG4886 205 TNLEELDLSGNQLTD--LpEPLANLTNLETLDLSNNQLTD--LPELGNLTNLEELDLSNNQLTD--LPPLANLTNLKTLD 278

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 413 LSFTVVTDSGLRKLSGLTSLRTLNLDarHVTDAGLSALTSLTGLTHLDLFGARITDSGTNHLRNLKKLQSLEICGGGLTD 492
Cdd:COG4886 279 LSNNQLTDLKLKELELLLGLNSLLLL--LLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLL 356

                       410       420       430
                ....*....|....*....|....*....|....*..
gi 30684506 493 TGVKNIKDLSSLTLLNLSQNSNLTDKTLELISGLTGL 529
Cdd:COG4886 357 NLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLL 393
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
299-571 1.67e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.58  E-value: 1.67e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 299 TAACLDTLTALAGLMYLNLnrcnfsdSGCEKFSDLINLKILNLGMNNITNSClVHLKGLTKLESLNLDSCRIGDEGLVhL 378
Cdd:COG4886  85 LLLGLTDLGDLTNLTELDL-------SGNEELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLPEP-L 155

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 379 SGMLELKSLELSDTEVGSNGlRHLSGLSNLESINLSFTVVTDSGLrKLSGLTSLRTLNLDARHVTDAGLSaLTSLTGLTH 458
Cdd:COG4886 156 GNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEP-LANLTNLET 232

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 459 LDLFGARITDsgTNHLRNLKKLQSLEICGGGLTDtgVKNIKDLSSLTLLNLSQNsNLTDKTLELISGLTGLVSLNVSNSR 538
Cdd:COG4886 233 LDLSNNQLTD--LPELGNLTNLEELDLSNNQLTD--LPPLANLTNLKTLDLSNN-QLTDLKLKELELLLGLNSLLLLLLL 307

                       250       260       270
                ....*....|....*....|....*....|...
gi 30684506 539 VSSSGLRHLKPLKNLRSLTLESCKLSANDIRKL 571
Cdd:COG4886 308 LNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 298-470 6.65e-12

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 67.00  E-value: 6.65e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 298 VTAACLDTLTALAGLMYLNLNRCNFSDSGCEKFSDL---INLKILNLGMNNITNSCLVHL-KGLT----KLESLNLDSCR 369
Cdd:cd00116  69 GLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDRGLRLLaKGLKdlppALEKLVLGRNR 148

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 370 IGDEGLVHLSGML----ELKSLELSDTEVGSNGLRHL----SGLSNLESINLSFTVVTDSGLRKLSG----LTSLRTLNL 437
Cdd:cd00116 149 LEGASCEALAKALranrDLKELNLANNGIGDAGIRALaeglKANCNLEVLDLNNNGLTDEGASALAEtlasLKSLEVLNL 228

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 30684506 438 DARHVTDAGLSALTS-----LTGLTHLDLFGARITDSG 470
Cdd:cd00116 229 GDNNLTDAGAAALASallspNISLLTLSLSCNDITDDG 266
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 306-468 4.18e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 62.11  E-value: 4.18e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 306 LTALAGLMYLNLNRCNFSDSGCEKFSDLI----NLKILNLGMNNITNSCLV----HLKGLTKLESLNLDSCRIGDEGLVH 377
Cdd:COG5238 232 LKGNKSLTTLDLSNNQIGDEGVIALAEALknntTVETLYLSGNQIGAEGAIalakALQGNTTLTSLDLSVNRIGDEGAIA 311

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 378 LSGMLE----LKSLELSDTEVGSNGLR----HLSGLSNLESINLSFTVVTDSGLRKLS----GLTSLRTLNLDARHVTDA 445
Cdd:COG5238 312 LAEGLQgnktLHTLNLAYNGIGAQGAIalakALQENTTLHSLDLSDNQIGDEGAIALAkyleGNTTLRELNLGKNNIGKQ 391

                       170       180
                ....*....|....*....|....*.
gi 30684506 446 GLSALTSL---TGLTHLDLFGARITD 468
Cdd:COG5238 392 GAEALIDAlqtNRLHTLILDGNLIGA 417
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 86-275 6.15e-08

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 53.49  E-value: 6.15e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506  86 DISQQIFDELVYSQRLTLKSLEaFRDCAIQDLYLGEYpgvnddwmdvisSQSTSLLSVDFSGS-DITDSGLVSL-KGCTN 163
Cdd:cd09293  13 QITQSNISQLLRILHSGLEWLE-LYMCPISDPPLDQL------------SNCNKLKKLILPGSkLIDDEGLIALaQSCPN 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 164 LESLNFNFCDQISNRGLVHLSG-LSNLTSLSFRRNA---AITAQGMRALS-NLVNLKKLDLEKCPGIDGGLVHL--RALT 236
Cdd:cd09293  80 LQVLDLRACENITDSGIVALATnCPKLQTINLGRHRnghLITDVSLSALGkNCTFLQTVGFAGCDVTDKGVWELasGCSK 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 30684506 237 KLESLNIKWCNCITDADMEPLSVLT---NLRSLQI-CCSKITD 275
Cdd:cd09293 160 SLERLSLNNCRNLTDQSIPAILASNyfpNLSVLEFrGCPLITD 202
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 183-398 6.16e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 54.67  E-value: 6.16e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 183 LSGLSNLTSLSFRRNA--AITAQGMRALSNLVNLKKLDLEKCPGIDGGLVHL-RALT----KLESLnIKWCNCITDADME 255
Cdd:cd00116  77 LTKGCGLQELDLSDNAlgPDGCGVLESLLRSSSLQELKLNNNGLGDRGLRLLaKGLKdlppALEKL-VLGRNRLEGASCE 155

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 256 PLS-VLTNLRSLQICcsKITDIGISylkglnklnllnLEGCRHVTAAcldtLTALAGLMYLNLNRCNFSDSG----CEKF 330
Cdd:cd00116 156 ALAkALRANRDLKEL--NLANNGIG------------DAGIRALAEG----LKANCNLEVLDLNNNGLTDEGasalAETL 217

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30684506 331 SDLINLKILNLGMNNITNSCLVHL-----KGLTKLESLNLDSCRIGDEGLVHLSG----MLELKSLELSDTEVGSNG 398
Cdd:cd00116 218 ASLKSLEVLNLGDNNLTDAGAAALasallSPNISLLTLSLSCNDITDDGAKDLAEvlaeKESLLELDLRGNKFGEEG 294
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 315-428 5.00e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.97  E-value: 5.00e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 315 LNLNRCNFSDSGCEKFSDLI----NLKILNLGMNNITNSCLVHL----KGLTKLESLNLDSCRIGDEGLVHLSGMLE--- 383
Cdd:cd00116 142 LVLGRNRLEGASCEALAKALranrDLKELNLANNGIGDAGIRALaeglKANCNLEVLDLNNNGLTDEGASALAETLAslk 221

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 30684506 384 -LKSLELSDTEVGSNGLRHL-----SGLSNLESINLSFTVVTDSGLRKLSG 428
Cdd:cd00116 222 sLEVLNLGDNNLTDAGAAALasallSPNISLLTLSLSCNDITDDGAKDLAE 272
LRR_8 pfam13855
Leucine rich repeat;
311-370 2.71e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 2.71e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506   311 GLMYLNLNRCNFSDSGCEKFSDLINLKILNLGMNNITNSCLVHLKGLTKLESLNLDSCRI 370
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 213-278 2.44e-04

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 42.70  E-value: 2.44e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30684506 213 NLKKLDLEKCPGIDGGLVHLRALTKLESLNIKWCNCITDADMEPLSV-LTNLRSLQI-CCSKITDIGI 278
Cdd:cd09293  29 GLEWLELYMCPISDPPLDQLSNCNKLKKLILPGSKLIDDEGLIALAQsCPNLQVLDLrACENITDSGI 96
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 335-474 4.75e-04

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 41.93  E-value: 4.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 335 NLKILNLGMNNITNSCLVHLKGLTKLESLNLDSCR-IGDEGLVHL-SGMLELKSLELSDTEVGSN-GLRHLSG-LSNLES 410
Cdd:cd09293  29 GLEWLELYMCPISDPPLDQLSNCNKLKKLILPGSKlIDDEGLIALaQSCPNLQVLDLRACENITDsGIVALATnCPKLQT 108

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30684506 411 INLSFT----VVTDSGLRKLSGL-TSLRTLNLDARHVTDAGLSALTSLTG--LTHLDLFGAR-ITDSGTNHL 474
Cdd:cd09293 109 INLGRHrnghLITDVSLSALGKNcTFLQTVGFAGCDVTDKGVWELASGCSksLERLSLNNCRnLTDQSIPAI 180
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 304-485 9.18e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 9.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506  304 DTLTALAGLMYLNLNRCNFSDSGCEKFsdLINLKILNLGMNNITNSCLVHLKGLTKLESLNLDSCRIGDEGLVHLSGMLE 383
Cdd:PLN00113 112 DIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTS 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506  384 LKSLELSDTEVGSNGLRHLSGLSNLESINLSFTVVTDSGLRKLSGLTSLRTLNLDARHVTDAGLSALTSLTGLTHLDLFG 463
Cdd:PLN00113 190 LEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQ 269

                        170       180
                 ....*....|....*....|..
gi 30684506  464 ARITDSGTNHLRNLKKLQSLEI 485
Cdd:PLN00113 270 NKLSGPIPPSIFSLQKLISLDL 291
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 406-485 1.01e-03

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 40.77  E-value: 1.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 406 SNLESINLSFTVVTDSGLRKLSGLTSLRTLNLDAR-HVTDAGLSALT-SLTGLTHLDLFG-ARITDSGTNHL-RNLKKLQ 481
Cdd:cd09293  28 SGLEWLELYMCPISDPPLDQLSNCNKLKKLILPGSkLIDDEGLIALAqSCPNLQVLDLRAcENITDSGIVALaTNCPKLQ 107


                ....
gi 30684506 482 SLEI 485
Cdd:cd09293 108 TINL 111
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 328-437 1.30e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.54  E-value: 1.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684506 328 EKFSDLINLKILNLGMNNItnSCLVHLKGLTKLESLNLDSCRIGDEG--------LVHLSGmlELKSLELSDTEVGSngL 399
Cdd:cd21340  62 ENLENLVNLKKLYLGGNRI--SVVEGLENLTNLEELHIENQRLPPGEkltfdprsLAALSN--SLRVLNISGNNIDS--L 135

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 30684506 400 RHLSGLSNLESINLS------FTVVTDSglrkLSGLTSLRTLNL 437
Cdd:cd21340 136 EPLAPLRNLEQLDASnnqisdLEELLDL----LSSWPSLRELDL 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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