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Conserved domains on  [gi|22329737|ref|NP_564178|]
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Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 1000094)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Ycf37 super family cl47397
Photosystem I assembly protein Ycf37, contains TPR repeats [Energy production and conversion]; ...
 133-282 2.12e-37

Photosystem I assembly protein Ycf37, contains TPR repeats [Energy production and conversion]; Photosystem I assembly protein Ycf37, contains TPR repeats is part of the Pathway/BioSystem: Photosystem I


The actual alignment was detected with superfamily member COG5714:

Pssm-ID: 444424 [Multi-domain]  Cd Length: 176  Bit Score: 130.83  E-value: 2.12e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329737 133 FYVIRQVLVRRELDLSAKELQEQVRSGDASATELFELGAVMLRRKFYPAANKFLQQAI-QKWDGDDQDLAQVYNALGVSY 211
Cdd:COG5714  22 IFVFRQILKTRRIESTLSRLQKKLKKEKGTAQEYYELGSIYLDKKLYVQAIALFQKALkAAEEEEPENLALIYNALGFAY 101

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22329737 212 VREDKLDKGIAQFEMAVKLQPGYVTAWNNLGDAYEKKKELPLALNAFEEVLLFDPNNKVARPRRDALKDRV 282
Cdd:COG5714 102 FAQEQYDLAIRQYKEALKLKPDYVTALNNLGHAYEKKKLTAQALETYEEALKLDPNNKTAKRRAESLRKRL 172
 
Name Accession Description Interval E-value
Ycf37 COG5714
Photosystem I assembly protein Ycf37, contains TPR repeats [Energy production and conversion]; ...
 133-282 2.12e-37

Photosystem I assembly protein Ycf37, contains TPR repeats [Energy production and conversion]; Photosystem I assembly protein Ycf37, contains TPR repeats is part of the Pathway/BioSystem: Photosystem I


Pssm-ID: 444424 [Multi-domain]  Cd Length: 176  Bit Score: 130.83  E-value: 2.12e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329737 133 FYVIRQVLVRRELDLSAKELQEQVRSGDASATELFELGAVMLRRKFYPAANKFLQQAI-QKWDGDDQDLAQVYNALGVSY 211
Cdd:COG5714  22 IFVFRQILKTRRIESTLSRLQKKLKKEKGTAQEYYELGSIYLDKKLYVQAIALFQKALkAAEEEEPENLALIYNALGFAY 101

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22329737 212 VREDKLDKGIAQFEMAVKLQPGYVTAWNNLGDAYEKKKELPLALNAFEEVLLFDPNNKVARPRRDALKDRV 282
Cdd:COG5714 102 FAQEQYDLAIRQYKEALKLKPDYVTALNNLGHAYEKKKLTAQALETYEEALKLDPNNKTAKRRAESLRKRL 172
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 174-271 1.09e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 56.25  E-value: 1.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329737   174 LRRKFYPAANKflqqAIQKWDGDDQDLAQVYNALGVSYVREDKLDKGIAQFEMAVKLQPGYVTAWNNLGDAYEKKKELPL 253
Cdd:TIGR02917 442 LRSGQFDKALA----AAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDD 517

                          90
                  ....*....|....*...
gi 22329737   254 ALNAFEEVLLFDPNNKVA 271
Cdd:TIGR02917 518 AIQRFEKVLTIDPKNLRA 535
TPR_1 pfam00515
Tetratricopeptide repeat;
237-268 1.76e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 40.87  E-value: 1.76e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 22329737   237 AWNNLGDAYEKKKELPLALNAFEEVLLFDPNN 268
Cdd:pfam00515   3 ALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 237-268 2.54e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 40.51  E-value: 2.54e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 22329737    237 AWNNLGDAYEKKKELPLALNAFEEVLLFDPNN 268
Cdd:smart00028   3 ALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
 
Name Accession Description Interval E-value
Ycf37 COG5714
Photosystem I assembly protein Ycf37, contains TPR repeats [Energy production and conversion]; ...
 133-282 2.12e-37

Photosystem I assembly protein Ycf37, contains TPR repeats [Energy production and conversion]; Photosystem I assembly protein Ycf37, contains TPR repeats is part of the Pathway/BioSystem: Photosystem I


Pssm-ID: 444424 [Multi-domain]  Cd Length: 176  Bit Score: 130.83  E-value: 2.12e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329737 133 FYVIRQVLVRRELDLSAKELQEQVRSGDASATELFELGAVMLRRKFYPAANKFLQQAI-QKWDGDDQDLAQVYNALGVSY 211
Cdd:COG5714  22 IFVFRQILKTRRIESTLSRLQKKLKKEKGTAQEYYELGSIYLDKKLYVQAIALFQKALkAAEEEEPENLALIYNALGFAY 101

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22329737 212 VREDKLDKGIAQFEMAVKLQPGYVTAWNNLGDAYEKKKELPLALNAFEEVLLFDPNNKVARPRRDALKDRV 282
Cdd:COG5714 102 FAQEQYDLAIRQYKEALKLKPDYVTALNNLGHAYEKKKLTAQALETYEEALKLDPNNKTAKRRAESLRKRL 172
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
146-268 6.93e-16

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 74.95  E-value: 6.93e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329737 146 DLSAKELQEQVRSGDASATELFELGAVMLRRKFYPAANKFLQQAIQkwdgDDQDLAQVYNALGVSYVREDKLDKGIAQFE 225
Cdd:COG4785  56 AALAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALE----LDPDLAEAYNNRGLAYLLLGDYDAALEDFD 131

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 22329737 226 MAVKLQPGYVTAWNNLGDAYEKKKELPLALNAFEEVLLFDPNN 268
Cdd:COG4785 132 RALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDPND 174
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 142-272 8.62e-16

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 77.34  E-value: 8.62e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329737 142 RRELDLSAKELQEQVRSGDASATELFELGAVMLRRKFYPAANKFLQQAIQKwdgdDQDLAQVYNALGVSYVREDKLDKGI 221
Cdd:COG3914  91 LGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALAL----NPDFAEAYLNLGEALRRLGRLEEAI 166

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 22329737 222 AQFEMAVKLQPGYVTAWNNLGDAYEKKKELPLALNAFEEVLLFDPNNKVAR 272
Cdd:COG3914 167 AALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAH 217
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
166-272 1.56e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 71.58  E-value: 1.56e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329737 166 LFELGAVMLRRKFYPAANKFLQQAIQKwdgdDQDLAQVYNALGVSYVREDKLDKGIAQFEMAVKLQPGYVTAWNNLGDAY 245
Cdd:COG0457  11 YNNLGLAYRRLGRYEEAIEDYEKALEL----DPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAL 86

                        90       100
                ....*....|....*....|....*..
gi 22329737 246 EKKKELPLALNAFEEVLLFDPNNKVAR 272
Cdd:COG0457  87 QALGRYEEALEDYDKALELDPDDAEAL 113
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
166-286 5.02e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.04  E-value: 5.02e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329737 166 LFELGAVMLRRKFYPAANKFLQQAIQKwdgdDQDLAQVYNALGVSYVREDKLDKGIAQFEMAVKLQPGYVTAWNNLGDAY 245
Cdd:COG0457  45 LYNLGLAYLRLGRYEEALADYEQALEL----DPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLAL 120

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 22329737 246 EKKKELPLALNAFEEVLLFDPNNKVARPRRDALKDRVKLYK 286
Cdd:COG0457 121 LELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYE 161
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
181-275 7.42e-13

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 66.48  E-value: 7.42e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329737 181 AANKFLQQAIQKWDGDDQDLAQVYNALGVSYVREDKLDKGIAQFEMAVKLQPGYVTAWNNLGDAYEKKKELPLALNAFEE 260
Cdd:COG4785  53 LAAAALAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDR 132

                        90
                ....*....|....*
gi 22329737 261 VLLFDPNNKVARPRR 275
Cdd:COG4785 133 ALELDPDYAYAYLNR 147
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 140-268 1.45e-12

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 63.67  E-value: 1.45e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329737 140 LVRRELDLSAKELQEQVRSGDASATELFELGAVMLRRKFYPAANKFLQQAIQKwdgdDQDLAQVYNALGVSYVREDKLDK 219
Cdd:COG4783  15 LLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALEL----DPDEPEARLNLGLALLKAGDYDE 90

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 22329737 220 GIAQFEMAVKLQPGYVTAWNNLGDAYEKKKELPLALNAFEEVLLFDPNN 268
Cdd:COG4783  91 ALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 160-291 1.94e-12

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 63.29  E-value: 1.94e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329737 160 DASATELFELGAVMLRRKFYPAANKFLQQAIQKwdgdDQDLAQVYNALGVSYVREDKLDKGIAQFEMAVKLQPGYVTAWN 239
Cdd:COG4783   1 AACAEALYALAQALLLAGDYDEAEALLEKALEL----DPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARL 76

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 22329737 240 NLGDAYEKKKELPLALNAFEEVLLFDPNNKVARPRRDALKDRVKLYKGVVAV 291
Cdd:COG4783  77 NLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAA 128
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
197-271 9.94e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 63.49  E-value: 9.94e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22329737 197 DQDLAQVYNALGVSYVREDKLDKGIAQFEMAVKLQPGYVTAWNNLGDAYEKKKELPLALNAFEEVLLFDPNNKVA 271
Cdd:COG0457   4 DPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEA 78
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 149-280 3.75e-11

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 59.63  E-value: 3.75e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329737 149 AKELQEQVRSGDASATELFELGAVMLRRKFYPAANKFLQQAIQKwdgdDQDLAQVYNALGVSYVREDKLDKGIAQFEMAV 228
Cdd:COG4235   3 IARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRL----DPDNADALLDLAEALLAAGDTEEAEELLERAL 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 22329737 229 KLQPGYVTAWNNLGDAYEKKKELPLALNAFEEVLLFDPNNKVARPRRDALKD 280
Cdd:COG4235  79 ALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPARLLEASIAE 130
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 140-272 7.42e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 61.28  E-value: 7.42e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329737 140 LVRRELDLSAKELQEQVRSGDASATELFELGAVMLRRKFYPAANKFLQQAIQKwdgdDQDLAQVYNALGVSYVREDKLDK 219
Cdd:COG2956  19 LLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLER----DPDRAEALLELAQDYLKAGLLDR 94

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 22329737 220 GIAQFEMAVKLQPGYVTAWNNLGDAYEKKKELPLALNAFEEVLLFDPNNKVAR 272
Cdd:COG2956  95 AEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAY 147
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 149-274 8.00e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 61.28  E-value: 8.00e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329737 149 AKELQEQVRSGDASATE-LFELGAVMLRRKFYPAANKFLQQAIQkwdgDDQDLAQVYNALGVSYVREDKLDKGIAQFEMA 227
Cdd:COG2956  95 AEELLEKLLELDPDDAEaLRLLAEIYEQEGDWEKAIEVLERLLK----LGPENAHAYCELAELYLEQGDYDEAIEALEKA 170

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 22329737 228 VKLQPGYVTAWNNLGDAYEKKKELPLALNAFEEVLLFDPNNKVARPR 274
Cdd:COG2956 171 LKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPR 217
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 140-266 1.28e-10

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 58.82  E-value: 1.28e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329737 140 LVRRELDLSAKELQEQVRSGDASATELFELGAVMLRRKFYPAANKFLQQAIQKwdgdDQDLAQVYNALGVSYVREDKLDK 219
Cdd:COG5010  31 LAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQL----DPNNPELYYNLALLYSRSGDKDE 106

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 22329737 220 GIAQFEMAVKLQPGYVTAWNNLGDAYEKKKELPLALNAFEEVLLFDP 266
Cdd:COG5010 107 AKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
166-286 1.58e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 60.02  E-value: 1.58e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329737 166 LFELGAVMLRRKFYPAANKFLQQAIQKwdgdDQDLAQVYNALGVSYVREDKLDKGIAQFEMAVKLQPGYVTAWNNLGDAY 245
Cdd:COG0457  79 LNNLGLALQALGRYEEALEDYDKALEL----DPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIAL 154

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 22329737 246 EKKKELPLALNAFEEVLLFDPNNKVARPRRDALKDRVKLYK 286
Cdd:COG0457 155 EKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEV 195
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
172-267 3.56e-10

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 55.95  E-value: 3.56e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329737 172 VMLRRKFYPAANKFLQQAIQKwdgdDQDLAQVYNALGVSYVREDKLDKGIaQFEMAVKLQPGYVTAWNNLGDAYEKKKEL 251
Cdd:COG3063   1 LYLKLGDLEEAEEYYEKALEL----DPDNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDY 75

                        90
                ....*....|....*.
gi 22329737 252 PLALNAFEEVLLFDPN 267
Cdd:COG3063  76 DEALAYLERALELDPS 91
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 142-268 3.90e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 59.36  E-value: 3.90e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329737 142 RRELDLSAKELQEQVRSGDASATELFELGAVMLRRKFYPAANKFLQQAIQKwdgdDQDLAQVYNALGVSYVREDKLDKGI 221
Cdd:COG2956 123 EGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKL----DPDCARALLLLAELYLEQGDYEEAI 198

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 22329737 222 AQFEMAVKLQPGYVTAWNNLGDAYEKKKELPLALNAFEEVLLFDPNN 268
Cdd:COG2956 199 AALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSD 245
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 174-271 1.09e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 56.25  E-value: 1.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329737   174 LRRKFYPAANKflqqAIQKWDGDDQDLAQVYNALGVSYVREDKLDKGIAQFEMAVKLQPGYVTAWNNLGDAYEKKKELPL 253
Cdd:TIGR02917 442 LRSGQFDKALA----AAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDD 517

                          90
                  ....*....|....*...
gi 22329737   254 ALNAFEEVLLFDPNNKVA 271
Cdd:TIGR02917 518 AIQRFEKVLTIDPKNLRA 535
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 165-272 1.98e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 52.66  E-value: 1.98e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329737 165 ELFELGAVMLRRKFYPAANKFLQQAIQKWDGDDQDLAQVYNALGVSYVREDKLDKGIAQFEMAVKLQPGYVTAWNNLGDA 244
Cdd:COG5010  18 TKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALL 97

                        90       100
                ....*....|....*....|....*...
gi 22329737 245 YEKKKELPLALNAFEEVLLFDPNNKVAR 272
Cdd:COG5010  98 YSRSGDKDEAKEYYEKALALSPDNPNAY 125
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 174-279 7.59e-07

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 46.91  E-value: 7.59e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329737 174 LRRKFYPAANKFLQQAIQKWDGDDQdLAQVYNALGVSYVREDKLDKGIAQFEMAVKLQPG---YVTAWNNLGDAYEKKKE 250
Cdd:COG1729   4 LKAGDYDEAIAAFKAFLKRYPNSPL-APDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDspkAPDALLKLGLSYLELGD 82

                        90       100
                ....*....|....*....|....*....
gi 22329737 251 LPLALNAFEEVLLFDPNNKVARPRRDALK 279
Cdd:COG1729  83 YDKARATLEELIKKYPDSEAAKEARARLA 111
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
211-272 1.21e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 45.93  E-value: 1.21e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22329737 211 YVREDKLDKGIAQFEMAVKLQPGYVTAWNNLGDAYEKKKELPLALnAFEEVLLFDPNNKVAR 272
Cdd:COG3063   2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEAL 62
TPR_1 pfam00515
Tetratricopeptide repeat;
237-268 1.76e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 40.87  E-value: 1.76e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 22329737   237 AWNNLGDAYEKKKELPLALNAFEEVLLFDPNN 268
Cdd:pfam00515   3 ALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 237-268 2.54e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 40.51  E-value: 2.54e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 22329737    237 AWNNLGDAYEKKKELPLALNAFEEVLLFDPNN 268
Cdd:smart00028   3 ALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR_12 pfam13424
Tetratricopeptide repeat;
199-262 8.67e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 40.06  E-value: 8.67e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22329737   199 DLAQVYNALGVSYVREDKLDKGIAQFEMAVKLQ--------PGYVTAWNNLGDAYEKKKELPLALNAFEEVL 262
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIArrllgpdhPLTATTLLNLGRLYLELGRYEEALELLERAL 72
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 137-268 3.11e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.38  E-value: 3.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329737   137 RQVLVRRELDLSAKELQEQVRSGDASATELFEL-GAVMLRRKFYPAANKFLQQAIQkwdgDDQDLAQVYNALGVSYVRED 215
Cdd:TIGR02917  98 RAYLLQGKFQQVLDELPGKTLLDDEGAAELLALrGLAYLGLGQLELAQKSYEQALA----IDPRSLYAKLGLAQLALAEN 173

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 22329737   216 KLDKGIAQFEMAVKLQPGYVTAWNNLGDAYEKKKELPLALNAFEEVLLFDPNN 268
Cdd:TIGR02917 174 RFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNN 226
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 237-267 1.03e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 35.96  E-value: 1.03e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 22329737   237 AWNNLGDAYEKKKELPLALNAFEEVLLFDPN 267
Cdd:pfam07719   3 ALYNLGLAYYKLGDYEEALEAYEKALELDPN 33
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 186-272 1.04e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.45  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329737   186 LQQAIQKwdgdDQDLAQVYNALGVSYVREDKLDKGIAQFEMAVKLQPGYVTAWNNLGDAYEKKKELPLALNAFEEVLLFD 265
Cdd:TIGR02917 420 LETAAQL----DPELGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIE 495


                  ....*..
gi 22329737   266 PNNKVAR 272
Cdd:TIGR02917 496 PDFFPAA 502
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
228-271 1.92e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.83  E-value: 1.92e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 22329737 228 VKLQPGYVTAWNNLGDAYEKKKELPLALNAFEEVLLFDPNNKVA 271
Cdd:COG0457   1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEA 44
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 145-296 3.16e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.91  E-value: 3.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329737   145 LDLSAKELQEQVRSGDASATELFELGAVMLRRKFYPAANKFLQQAIQKwdgDDQDLAQvYNALGVSYVREDKLDKGIAQF 224
Cdd:TIGR02917 515 PDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEKAAEL---NPQEIEP-ALALAQYYLGKGQLKKALAIL 590

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22329737   225 EMAVKLQPGYVTAWNNLGDAYEKKKELPLALNAFEEVLLFDPNNKVARPRRDALKDRVKLYKGvvAVKSKKR 296
Cdd:TIGR02917 591 NEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAK--AITSLKR 660
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 168-272 4.33e-03

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 37.70  E-value: 4.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329737   168 ELGAVMLRRKFYPAANKFLQQAIQKwdgdDQDLAQVYNALGVSYVREDKL------------------------------ 217
Cdd:TIGR02521  36 QLALGYLEQGDLEVAKENLDKALEH----DPDDYLAYLALALYYQQLGELekaedsfrraltlnpnngdvlnnygtflcq 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22329737   218 ----DKGIAQFEMAVKlQPGYVT---AWNNLGDAYEKKKELPLALNAFEEVLLFDPNNKVAR 272
Cdd:TIGR02521 112 qgkyEQAMQQFEQAIE-DPLYPQparSLENAGLCALKAGDFDKAEKYLTRALQIDPQRPESL 172
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 206-268 4.76e-03

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 35.00  E-value: 4.76e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22329737   206 ALGVSYVREDKLDKGIAQFEMAVKLQ---PGYVTAWNNLGDAYEKKKELPLALNAFEEVLLFDPNN 268
Cdd:pfam13432   2 ALARAALRAGDYDDAAAALEAALARFpesPDAAAALLLLGLAALRQGRLAEAAAAYRAALRAAPGD 67
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 209-271 8.10e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 35.35  E-value: 8.10e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22329737 209 VSYVREDKLDKGIAQFEMAVKLQPG---YVTAWNNLGDAYEKKKELPLALNAFEEVLLFDPNNKVA 271
Cdd:COG1729   1 KALLKAGDYDEAIAAFKAFLKRYPNsplAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKA 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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