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Conserved domains on  [gi|18396311|ref|NP_564282|]
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phosphoribosylformylglycinamidine synthase [Arabidopsis thaliana]

Protein Classification

DUF493 domain-containing protein( domain architecture ID 10516171)

DUF493 domain-containing protein similar to Helicobacter Pylori Hp0495

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF493 pfam04359
Protein of unknown function (DUF493); This domain is likely to act in a regulatory capacity ...
 117-202 4.87e-23

Protein of unknown function (DUF493); This domain is likely to act in a regulatory capacity like pfam01842 domains. This domain has a remarkable property in that the C-terminal residue of every protein in the family lies up in the alignment. This suggests that the C-terminal residue plays some important functional role (Bateman A pers obs).


:

Pssm-ID: 461274  Cd Length: 84  Bit Score: 87.95  E-value: 4.87e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396311   117 QKVNTYPTERGFTAIGTGGNDFVHAMVVAVESVIDRQIPEDcVKQTLSSKGKYVSVNIgPIQVVSSEQVQAVYNAMRRDE 196
Cdd:pfam04359   1 EPLIEFPCDFPIKVIGLAEDDFVDAVVEVVQRHAPDFDPET-VEVRPSSKGKYVSVTV-TVTVTSREQLDAIYRALKAHP 78


                  ....*.
gi 18396311   197 RMKYFL 202
Cdd:pfam04359  79 RVKMVL 84
 
Name Accession Description Interval E-value
DUF493 pfam04359
Protein of unknown function (DUF493); This domain is likely to act in a regulatory capacity ...
 117-202 4.87e-23

Protein of unknown function (DUF493); This domain is likely to act in a regulatory capacity like pfam01842 domains. This domain has a remarkable property in that the C-terminal residue of every protein in the family lies up in the alignment. This suggests that the C-terminal residue plays some important functional role (Bateman A pers obs).


Pssm-ID: 461274  Cd Length: 84  Bit Score: 87.95  E-value: 4.87e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396311   117 QKVNTYPTERGFTAIGTGGNDFVHAMVVAVESVIDRQIPEDcVKQTLSSKGKYVSVNIgPIQVVSSEQVQAVYNAMRRDE 196
Cdd:pfam04359   1 EPLIEFPCDFPIKVIGLAEDDFVDAVVEVVQRHAPDFDPET-VEVRPSSKGKYVSVTV-TVTVTSREQLDAIYRALKAHP 78


                  ....*.
gi 18396311   197 RMKYFL 202
Cdd:pfam04359  79 RVKMVL 84
YbeD COG2921
Putative lipoate-binding regulatory protein, UPF0250 family [Signal transduction mechanisms];
122-202 2.73e-10

Putative lipoate-binding regulatory protein, UPF0250 family [Signal transduction mechanisms];


Pssm-ID: 442165  Cd Length: 88  Bit Score: 54.78  E-value: 2.73e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396311 122 YPTERGFTAIGTGGNDFVHAMVvaveSVIDRQIP---EDCVKQTLSSKGKYVSVNIgPIQVVSSEQVQAVYNAMRRDERM 198
Cdd:COG2921  10 FPCDFPIKVMGLADDDFVDAVV----EVVQRHAPdfdPETISVRPSSKGKYLSVTV-TITATSREQLDALYRALTAHPLV 84


                ....
gi 18396311 199 KYFL 202
Cdd:COG2921  85 KMVL 88
PRK04998 PRK04998
hypothetical protein; Provisional
 143-190 1.09e-03

hypothetical protein; Provisional


Pssm-ID: 179912  Cd Length: 88  Bit Score: 36.81  E-value: 1.09e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 18396311  143 VVAVesvIDRQIPEDCVKQT-LSSKGKYVSVNIgPIQVVSSEQVQAVYN 190
Cdd:PRK04998  32 VVEV---VQRHAPGDYTPTVkPSSKGNYHSVSI-TITATSIEQVETLYE 76
 
Name Accession Description Interval E-value
DUF493 pfam04359
Protein of unknown function (DUF493); This domain is likely to act in a regulatory capacity ...
 117-202 4.87e-23

Protein of unknown function (DUF493); This domain is likely to act in a regulatory capacity like pfam01842 domains. This domain has a remarkable property in that the C-terminal residue of every protein in the family lies up in the alignment. This suggests that the C-terminal residue plays some important functional role (Bateman A pers obs).


Pssm-ID: 461274  Cd Length: 84  Bit Score: 87.95  E-value: 4.87e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396311   117 QKVNTYPTERGFTAIGTGGNDFVHAMVVAVESVIDRQIPEDcVKQTLSSKGKYVSVNIgPIQVVSSEQVQAVYNAMRRDE 196
Cdd:pfam04359   1 EPLIEFPCDFPIKVIGLAEDDFVDAVVEVVQRHAPDFDPET-VEVRPSSKGKYVSVTV-TVTVTSREQLDAIYRALKAHP 78


                  ....*.
gi 18396311   197 RMKYFL 202
Cdd:pfam04359  79 RVKMVL 84
YbeD COG2921
Putative lipoate-binding regulatory protein, UPF0250 family [Signal transduction mechanisms];
122-202 2.73e-10

Putative lipoate-binding regulatory protein, UPF0250 family [Signal transduction mechanisms];


Pssm-ID: 442165  Cd Length: 88  Bit Score: 54.78  E-value: 2.73e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396311 122 YPTERGFTAIGTGGNDFVHAMVvaveSVIDRQIP---EDCVKQTLSSKGKYVSVNIgPIQVVSSEQVQAVYNAMRRDERM 198
Cdd:COG2921  10 FPCDFPIKVMGLADDDFVDAVV----EVVQRHAPdfdPETISVRPSSKGKYLSVTV-TITATSREQLDALYRALTAHPLV 84


                ....
gi 18396311 199 KYFL 202
Cdd:COG2921  85 KMVL 88
PRK04998 PRK04998
hypothetical protein; Provisional
 143-190 1.09e-03

hypothetical protein; Provisional


Pssm-ID: 179912  Cd Length: 88  Bit Score: 36.81  E-value: 1.09e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 18396311  143 VVAVesvIDRQIPEDCVKQT-LSSKGKYVSVNIgPIQVVSSEQVQAVYN 190
Cdd:PRK04998  32 VVEV---VQRHAPGDYTPTVkPSSKGNYHSVSI-TITATSIEQVETLYE 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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