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Conserved domains on  [gi|18408265|ref|NP_564849|]
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TRAF-like family protein [Arabidopsis thaliana]

Protein Classification

MATH domain-containing protein( domain architecture ID 11110250)

MATH (meprin and TRAF-C homology) domain-containing protein similar to Caenorhabditis elegans MATH domain-containing protein

Gene Ontology:  GO:0005515
PubMed:  12387856|17633013

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MATH pfam00917
MATH domain; This motif has been called the Meprin And TRAF-Homology (MATH) domain. This ...
 102-220 2.22e-23

MATH domain; This motif has been called the Meprin And TRAF-Homology (MATH) domain. This domain is hugely expanded in the nematode C. elegans.


:

Pssm-ID: 425944 [Multi-domain]  Cd Length: 113  Bit Score: 90.39  E-value: 2.22e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408265   102 IRDFSVLKQND-CISKTFAMGGKNWTLTVYPKGDseadnEFCKYLHLADGEVLSPGEMISVRAQLRALDPRGSK-HKTvw 179
Cdd:pfam00917   1 IKNFSKIKEGEsYYSPVEERFNIPWRLQIYRKGG-----FLGLYLHCDKEEELERGWSIETEFTLKLVSSNGKSvTKT-- 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 18408265   180 lQQWIMAATKARGIPQSLSLADLQEAYLDEDTLNVEIECEV 220
Cdd:pfam00917  74 -DTHVFEKPKGWGWGKFISWDDLEKDYLVDDSITVEAHVKI 113
 
Name Accession Description Interval E-value
MATH pfam00917
MATH domain; This motif has been called the Meprin And TRAF-Homology (MATH) domain. This ...
 102-220 2.22e-23

MATH domain; This motif has been called the Meprin And TRAF-Homology (MATH) domain. This domain is hugely expanded in the nematode C. elegans.


Pssm-ID: 425944 [Multi-domain]  Cd Length: 113  Bit Score: 90.39  E-value: 2.22e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408265   102 IRDFSVLKQND-CISKTFAMGGKNWTLTVYPKGDseadnEFCKYLHLADGEVLSPGEMISVRAQLRALDPRGSK-HKTvw 179
Cdd:pfam00917   1 IKNFSKIKEGEsYYSPVEERFNIPWRLQIYRKGG-----FLGLYLHCDKEEELERGWSIETEFTLKLVSSNGKSvTKT-- 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 18408265   180 lQQWIMAATKARGIPQSLSLADLQEAYLDEDTLNVEIECEV 220
Cdd:pfam00917  74 -DTHVFEKPKGWGWGKFISWDDLEKDYLVDDSITVEAHVKI 113
MATH cd00121
MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded ...
 97-220 1.54e-21

MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane and are capable of cleaving growth factors, extracellular matrix proteins, and biologically active peptides. TRAF molecules serve as adapter proteins that link cell surface receptors of the Tumor Necrosis Factor and 1nterleukin-1/Toll-like families to downstream kinase cascades, which results in the activation of transcription factors and the regulation of cell survival, proliferation and stress responses in the immune and inflammatory systems. Other members include the ubiquitin ligases, TRIM37 and SPOP, and the ubiquitin-specific proteases, HAUSP and Ubp21p. A large number of uncharacterized members mostly from lineage-specific expansions in C. elegans and rice contain MATH and BTB domains, similar to SPOP. The MATH domain has been shown to bind peptide/protein substrates in TRAFs and HAUSP. It is possible that the MATH domain in other members of this superfamily also interacts with various protein substrates. The TRAF domain may also be involved in the trimerization of TRAFs. Based on homology, it is postulated that the MATH domain in meprins may be involved in its tetramer assembly and that the MATH domain, in general, may take part in diverse modular arrangements defined by adjacent multimerization domains.


Pssm-ID: 238068  Cd Length: 126  Bit Score: 86.28  E-value: 1.54e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408265  97 KFSWSIRDFSVLKQNDCISKTFAMGGKNWTLTVYPKGDSEADNEFCKYLHLADGEVLSPGEMISVRAQLRALDPRGSKHK 176
Cdd:cd00121   2 KHTWKIVNFSELEGESIYSPPFEVGGYKWRIRIYPNGDGESGDYLSLYLELDKGESDLEKWSVRAEFTLKLVNQNGGKSL 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 18408265 177 TVWLQQWIMAAT-KARGIPQSLSLADLQEAY-LDEDTLNveIECEV 220
Cdd:cd00121  82 SKSFTHVFFSEKgSGWGFPKFISWDDLEDSYyLVDDSLT--IEVEV 125
COG5077 COG5077
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, ...
 71-133 9.01e-04

Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227409 [Multi-domain]  Cd Length: 1089  Bit Score: 39.85  E-value: 9.01e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18408265   71 GEPCEFGAHVKIASSPVPVD---ENLPFHKFSWSIRDFSVLkQNDCISKTFAMGGKNWTLTVYPKG 133
Cdd:COG5077   11 GEVFPGSPDKSIGSILPQFDpdvEELLEMSFTWKVKRWSEL-AKKVESPPFSVGGHTWKIILFPQG 75
MATH smart00061
meprin and TRAF homology;
98-177 5.42e-03

meprin and TRAF homology;


Pssm-ID: 214496 [Multi-domain]  Cd Length: 95  Bit Score: 35.35  E-value: 5.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408265     98 FSWSIRDFSVLKQNDCI-SKTFAMGGKNWTLTVYPKGDSeadneFCKYLHLADGEVLSPGEMISVRAQLRALDPRGSKHK 176
Cdd:smart00061   2 LSHTFKNVSRLEEGESYfSPSEEHFNIPWRLKIYRKNGF-----LSLYLHCEKEECDSRKWSIEAEFTLKLVSQNGKSLS 76


                   .
gi 18408265    177 T 177
Cdd:smart00061  77 K 77
 
Name Accession Description Interval E-value
MATH pfam00917
MATH domain; This motif has been called the Meprin And TRAF-Homology (MATH) domain. This ...
 102-220 2.22e-23

MATH domain; This motif has been called the Meprin And TRAF-Homology (MATH) domain. This domain is hugely expanded in the nematode C. elegans.


Pssm-ID: 425944 [Multi-domain]  Cd Length: 113  Bit Score: 90.39  E-value: 2.22e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408265   102 IRDFSVLKQND-CISKTFAMGGKNWTLTVYPKGDseadnEFCKYLHLADGEVLSPGEMISVRAQLRALDPRGSK-HKTvw 179
Cdd:pfam00917   1 IKNFSKIKEGEsYYSPVEERFNIPWRLQIYRKGG-----FLGLYLHCDKEEELERGWSIETEFTLKLVSSNGKSvTKT-- 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 18408265   180 lQQWIMAATKARGIPQSLSLADLQEAYLDEDTLNVEIECEV 220
Cdd:pfam00917  74 -DTHVFEKPKGWGWGKFISWDDLEKDYLVDDSITVEAHVKI 113
MATH cd00121
MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded ...
 97-220 1.54e-21

MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane and are capable of cleaving growth factors, extracellular matrix proteins, and biologically active peptides. TRAF molecules serve as adapter proteins that link cell surface receptors of the Tumor Necrosis Factor and 1nterleukin-1/Toll-like families to downstream kinase cascades, which results in the activation of transcription factors and the regulation of cell survival, proliferation and stress responses in the immune and inflammatory systems. Other members include the ubiquitin ligases, TRIM37 and SPOP, and the ubiquitin-specific proteases, HAUSP and Ubp21p. A large number of uncharacterized members mostly from lineage-specific expansions in C. elegans and rice contain MATH and BTB domains, similar to SPOP. The MATH domain has been shown to bind peptide/protein substrates in TRAFs and HAUSP. It is possible that the MATH domain in other members of this superfamily also interacts with various protein substrates. The TRAF domain may also be involved in the trimerization of TRAFs. Based on homology, it is postulated that the MATH domain in meprins may be involved in its tetramer assembly and that the MATH domain, in general, may take part in diverse modular arrangements defined by adjacent multimerization domains.


Pssm-ID: 238068  Cd Length: 126  Bit Score: 86.28  E-value: 1.54e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408265  97 KFSWSIRDFSVLKQNDCISKTFAMGGKNWTLTVYPKGDSEADNEFCKYLHLADGEVLSPGEMISVRAQLRALDPRGSKHK 176
Cdd:cd00121   2 KHTWKIVNFSELEGESIYSPPFEVGGYKWRIRIYPNGDGESGDYLSLYLELDKGESDLEKWSVRAEFTLKLVNQNGGKSL 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 18408265 177 TVWLQQWIMAAT-KARGIPQSLSLADLQEAY-LDEDTLNveIECEV 220
Cdd:cd00121  82 SKSFTHVFFSEKgSGWGFPKFISWDDLEDSYyLVDDSLT--IEVEV 125
COG5077 COG5077
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, ...
 71-133 9.01e-04

Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227409 [Multi-domain]  Cd Length: 1089  Bit Score: 39.85  E-value: 9.01e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18408265   71 GEPCEFGAHVKIASSPVPVD---ENLPFHKFSWSIRDFSVLkQNDCISKTFAMGGKNWTLTVYPKG 133
Cdd:COG5077   11 GEVFPGSPDKSIGSILPQFDpdvEELLEMSFTWKVKRWSEL-AKKVESPPFSVGGHTWKIILFPQG 75
MATH smart00061
meprin and TRAF homology;
98-177 5.42e-03

meprin and TRAF homology;


Pssm-ID: 214496 [Multi-domain]  Cd Length: 95  Bit Score: 35.35  E-value: 5.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408265     98 FSWSIRDFSVLKQNDCI-SKTFAMGGKNWTLTVYPKGDSeadneFCKYLHLADGEVLSPGEMISVRAQLRALDPRGSKHK 176
Cdd:smart00061   2 LSHTFKNVSRLEEGESYfSPSEEHFNIPWRLKIYRKNGF-----LSLYLHCEKEECDSRKWSIEAEFTLKLVSQNGKSLS 76


                   .
gi 18408265    177 T 177
Cdd:smart00061  77 K 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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