|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02569 |
PLN02569 |
threonine synthase |
30-513 |
0e+00 |
|
threonine synthase
Pssm-ID: 178182 [Multi-domain] Cd Length: 484 Bit Score: 983.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 30 TVRCTSASPAVPPQTPQKPRRSPDENIRDEARRR-PHQLQNLSARYVPFNAPPSSTESYSLDEIVYRSQSGALLDVQHDF 108
Cdd:PLN02569 1 VASVTRAVISDPPPIKSATKFTADENIRDEARRGpPAPPDEFSAKYVPFLECPLTGEKYSLDEVVYRSKSGGLLDVRHDM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 109 AALKRYDGEFWRNLFDSRVGKTNWPYGSGVWSKKEWVLPEIDDDDIVSAFEGNSNLFWAERFGKQYLQMNDLWVKHCGIS 188
Cdd:PLN02569 81 EALKRYDGKYWRALFDSRVGKTTWPYGSGVWSKKEWVLPEIDDDDIVSLFEGNSNLFWAERLGKEFLGMNDLWVKHCGIS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 189 HTGSFKDLGMSVLVSQVNRLRKMNKPVIGVGCASTGDTSAALSAYCASAGIPSIVFLPADKISMAQLVQPIANGAFVLSI 268
Cdd:PLN02569 161 HTGSFKDLGMTVLVSQVNRLRKMAKPVVGVGCASTGDTSAALSAYCAAAGIPSIVFLPADKISIAQLVQPIANGALVLSI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 269 DTDFDGCMHLIREVTAELPIYLANSLNSLRLEGQKTAAIEILQQFNWQVPDWVIVPGGNLGNIYAFYKGFHMCKELGLVD 348
Cdd:PLN02569 241 DTDFDGCMRLIREVTAELPIYLANSLNSLRLEGQKTAAIEILQQFDWEVPDWVIVPGGNLGNIYAFYKGFKMCKELGLVD 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 349 RIPRLVCAQAANANPLYLHYKSGFkEDFNPLKANTTFASAIQIGDPVSIDRAVYALKKSNGIVEEATEEELMDATALADS 428
Cdd:PLN02569 321 RLPRLVCAQAANANPLYRAYKSGW-EEFKPVKANPTFASAIQIGDPVSIDRAVYALKESNGIVEEATEEELMDAQAEADK 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 429 TGMFICPHTGVALTALMKLRKSGVIGANDRTVVVSTAHGLKFTQSKIDYHSKNIKEMACRLANPPVKVKAKFGSVMDVLK 508
Cdd:PLN02569 400 TGMFLCPHTGVALAALKKLRASGVIGPTDRTVVVSTAHGLKFTQSKIDYHSKEIPDMACRFANPPVSVKADFGSVMDVLK 479
|
....*
gi 18410191 509 EYLKS 513
Cdd:PLN02569 480 KYLSL 484
|
|
| Thr-synth_1 |
cd01563 |
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last ... |
139-470 |
6.27e-155 |
|
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants.
Pssm-ID: 107206 [Multi-domain] Cd Length: 324 Bit Score: 444.34 E-value: 6.27e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 139 WSKKEWVLPeIDDDDIVSAFEGNSNLFWAERFGKQyLQMNDLWVKHCGISHTGSFKDLGMSVLVSQVNRLRkmnkpVIGV 218
Cdd:cd01563 1 LWRYRELLP-VTEDDIVSLGEGNTPLVRAPRLGER-LGGKNLYVKDEGLNPTGSFKDRGMTVAVSKAKELG-----VKAV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 219 GCASTGDTSAALSAYCASAGIPSIVFLPADKiSMAQLVQPIANGAFVLSIDTDFDGCMHLIREVTAELPIYLANSLNSLR 298
Cdd:cd01563 74 ACASTGNTSASLAAYAARAGIKCVVFLPAGK-ALGKLAQALAYGATVLAVEGNFDDALRLVRELAEENWIYLSNSLNPYR 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 299 LEGQKTAAIEILQQFNWQVPDWVIVPGGNLGNIYAFYKGFHMCKELGLVDRIPRLVCAQAANANPLYLHYKSGfKEDFNP 378
Cdd:cd01563 153 LEGQKTIAFEIAEQLGWEVPDYVVVPVGNGGNITAIWKGFKELKELGLIDRLPRMVGVQAEGAAPIVRAFKEG-KDDIEP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 379 LKANTTFASAIQIGDPVSIDRAVYALKKSNGIVEEATEEELMDATALADST-GMFICPHTGVALTALMKLRKSGVIGAND 457
Cdd:cd01563 232 VENPETIATAIRIGNPASGPKALRAVRESGGTAVAVSDEEILEAQKLLARTeGIFVEPASAASLAGLKKLREEGIIDKGE 311
|
330
....*....|...
gi 18410191 458 RTVVVSTAHGLKF 470
Cdd:cd01563 312 RVVVVLTGHGLKD 324
|
|
| ThrC |
COG0498 |
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the ... |
125-509 |
1.14e-139 |
|
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the Pathway/BioSystem: Threonine biosynthesis
Pssm-ID: 440264 [Multi-domain] Cd Length: 394 Bit Score: 408.05 E-value: 1.14e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 125 SRVGKTNWPYGSGVWSKKEWvLPEIDDDDIVSAFEGNSNLFWAERFGKQYlqMNDLWVKHCGISHTGSFKDLGMSVLVSq 204
Cdd:COG0498 31 PALSREDLASRRGLWRYREL-LPFDDEEKAVSLGEGGTPLVKAPRLADEL--GKNLYVKEEGHNPTGSFKDRAMQVAVS- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 205 vnRLRKMNKPVIGvgCASTGDTSAALSAYCASAGIPSIVFLPADKISMAQLVQPIANGAFVLSIDTDFDGCMHLIREVTA 284
Cdd:COG0498 107 --LALERGAKTIV--CASSGNGSAALAAYAARAGIEVFVFVPEGKVSPGQLAQMLTYGAHVIAVDGNFDDAQRLVKELAA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 285 ELPIYLANSLNSLRLEGQKTAAIEILQQFNwQVPDWVIVPGGNLGNIYAFYKGFHMCKELGLVDRIPRLVCAQAANANPL 364
Cdd:COG0498 183 DEGLYAVNSINPARLEGQKTYAFEIAEQLG-RVPDWVVVPTGNGGNILAGYKAFKELKELGLIDRLPRLIAVQATGCNPI 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 365 YLHYKSGfKEDFNPLKANTTfASAIQIGDPVSIDRAVYALKKSNGIVEEATEEELMDATA-LADSTGMFICPHTGVALTA 443
Cdd:COG0498 262 LTAFETG-RDEYEPERPETI-APSMDIGNPSNGERALFALRESGGTAVAVSDEEILEAIRlLARREGIFVEPATAVAVAG 339
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18410191 444 LMKLRKSGVIGANDRTVVVSTAHGLKFTQSKIDYHSKNikemacrlanpPVKVKAKFGSVMDVLKE 509
Cdd:COG0498 340 LRKLREEGEIDPDEPVVVLSTGHGLKFPDAVREALGGE-----------PLAVPPDLEAVKAAVEE 394
|
|
| thrC |
TIGR00260 |
threonine synthase; Involved in threonine biosynthesis it catalyses the reaction ... |
138-469 |
3.86e-82 |
|
threonine synthase; Involved in threonine biosynthesis it catalyses the reaction O-PHOSPHO-L-HOMOSERINE + H(2)O = L-THREONINE + ORTHOPHOSPHATE using pyridoxal phosphate as a cofactor. the enzyme is distantly related to the serine/threonine dehydratases which are also pyridoxal-phosphate dependent enzymes. the pyridoxal-phosphate binding site is a Lys (K) residues present at residue 70 of the model. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 272986 [Multi-domain] Cd Length: 327 Bit Score: 258.47 E-value: 3.86e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 138 VWSKKEwVLPEIDDDdIVSAFEGNSNLFWAERFGKQyLQMNDLWVKHCGISHTGSFKDLGMSVLVSQVNRLRkmnkpVIG 217
Cdd:TIGR00260 1 VWRYRE-FLPVTEKD-LVDLGEGVTPLFRAPALAAN-VGIKNLYVKELGHNPTLSFKDRGMAVALTKALELG-----NDT 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 218 VGCASTGDTSAALSAYCASAGIPSIVFLPADKISMAQLVQPIANGAFVLSIDTDFDGCMHLIREVTAELPIYLANSLNSL 297
Cdd:TIGR00260 73 VLCASTGNTGAAAAAYAGKAGLKVVVLYPAGKISLGKLAQALGYNAEVVAIDGNFDDAQRLVKQLFEDKPALGLNSANSI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 298 --RLEGQKTAAIEILQQFNWQVPDWVIVPGGNLGNIYAFYKGFHMCKELGLvDRIPRLVCAQAANANPLYLHYKSGfkED 375
Cdd:TIGR00260 153 pyRLEGQKTYAFEAVEQLGWEAPDKVVVPVPNSGNFGAIWKGFKEKKMLGL-DSLPVKRGIQAEGAADIVRAFLEG--GQ 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 376 FNPLKANTTFASAIQIGDPVSIDRAVYALKKSNGIVEEATEEELMDATA-LADSTGMFICPHTGVALTALMKLRKSGVIG 454
Cdd:TIGR00260 230 WEPIETPETLSTAMDIGNPANWPRALEAFRRSNGYAEDLSDEEILEAIKlLAREEGYFVEPHSAVAVAALLKLVEKGTAD 309
|
330
....*....|....*
gi 18410191 455 ANDRTVVVSTAHGLK 469
Cdd:TIGR00260 310 PAERVVCALTGNGLK 324
|
|
| PALP |
pfam00291 |
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ... |
155-464 |
3.20e-54 |
|
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.
Pssm-ID: 459749 [Multi-domain] Cd Length: 295 Bit Score: 184.44 E-value: 3.20e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 155 VSAFEGNSNLFWAERFGKQYLQmnDLWVKHCGISHTGSFKDLGMSVLVSQVNRlrkmNKPVIGVGCASTGDTSAALSAYC 234
Cdd:pfam00291 1 ISLGIGPTPLVRLPRLSKELGV--DVYLKLESLNPTGSFKDRGALNLLLRLKE----GEGGKTVVEASSGNHGRALAAAA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 235 ASAGIPSIVFLPAD----KISMAQLVqpianGAFVLSIDTDFDGCMHLIREVTAELP--IYLANSLNSLRLEGQKTAAIE 308
Cdd:pfam00291 75 ARLGLKVTIVVPEDappgKLLLMRAL-----GAEVVLVGGDYDEAVAAARELAAEGPgaYYINQYDNPLNIEGYGTIGLE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 309 ILQQFNwQVPDWVIVPGGNLGNIYAFYKGFhmcKELGlvdRIPRLVCAQAANANPLylhYKSGFKEDFNPLKANTTFASA 388
Cdd:pfam00291 150 ILEQLG-GDPDAVVVPVGGGGLIAGIARGL---KELG---PDVRVIGVEPEGAPAL---ARSLAAGRPVPVPVADTIADG 219
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18410191 389 IQIGDPVSiDRAVYALKKSNGIVEEATEEELMDATA-LADSTGMFICPHTGVALTALmKLRKSGVIGANDRTVVVST 464
Cdd:pfam00291 220 LGVGDEPG-ALALDLLDEYVGEVVTVSDEEALEAMRlLARREGIVVEPSSAAALAAL-KLALAGELKGGDRVVVVLT 294
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02569 |
PLN02569 |
threonine synthase |
30-513 |
0e+00 |
|
threonine synthase
Pssm-ID: 178182 [Multi-domain] Cd Length: 484 Bit Score: 983.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 30 TVRCTSASPAVPPQTPQKPRRSPDENIRDEARRR-PHQLQNLSARYVPFNAPPSSTESYSLDEIVYRSQSGALLDVQHDF 108
Cdd:PLN02569 1 VASVTRAVISDPPPIKSATKFTADENIRDEARRGpPAPPDEFSAKYVPFLECPLTGEKYSLDEVVYRSKSGGLLDVRHDM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 109 AALKRYDGEFWRNLFDSRVGKTNWPYGSGVWSKKEWVLPEIDDDDIVSAFEGNSNLFWAERFGKQYLQMNDLWVKHCGIS 188
Cdd:PLN02569 81 EALKRYDGKYWRALFDSRVGKTTWPYGSGVWSKKEWVLPEIDDDDIVSLFEGNSNLFWAERLGKEFLGMNDLWVKHCGIS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 189 HTGSFKDLGMSVLVSQVNRLRKMNKPVIGVGCASTGDTSAALSAYCASAGIPSIVFLPADKISMAQLVQPIANGAFVLSI 268
Cdd:PLN02569 161 HTGSFKDLGMTVLVSQVNRLRKMAKPVVGVGCASTGDTSAALSAYCAAAGIPSIVFLPADKISIAQLVQPIANGALVLSI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 269 DTDFDGCMHLIREVTAELPIYLANSLNSLRLEGQKTAAIEILQQFNWQVPDWVIVPGGNLGNIYAFYKGFHMCKELGLVD 348
Cdd:PLN02569 241 DTDFDGCMRLIREVTAELPIYLANSLNSLRLEGQKTAAIEILQQFDWEVPDWVIVPGGNLGNIYAFYKGFKMCKELGLVD 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 349 RIPRLVCAQAANANPLYLHYKSGFkEDFNPLKANTTFASAIQIGDPVSIDRAVYALKKSNGIVEEATEEELMDATALADS 428
Cdd:PLN02569 321 RLPRLVCAQAANANPLYRAYKSGW-EEFKPVKANPTFASAIQIGDPVSIDRAVYALKESNGIVEEATEEELMDAQAEADK 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 429 TGMFICPHTGVALTALMKLRKSGVIGANDRTVVVSTAHGLKFTQSKIDYHSKNIKEMACRLANPPVKVKAKFGSVMDVLK 508
Cdd:PLN02569 400 TGMFLCPHTGVALAALKKLRASGVIGPTDRTVVVSTAHGLKFTQSKIDYHSKEIPDMACRFANPPVSVKADFGSVMDVLK 479
|
....*
gi 18410191 509 EYLKS 513
Cdd:PLN02569 480 KYLSL 484
|
|
| Thr-synth_1 |
cd01563 |
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last ... |
139-470 |
6.27e-155 |
|
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants.
Pssm-ID: 107206 [Multi-domain] Cd Length: 324 Bit Score: 444.34 E-value: 6.27e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 139 WSKKEWVLPeIDDDDIVSAFEGNSNLFWAERFGKQyLQMNDLWVKHCGISHTGSFKDLGMSVLVSQVNRLRkmnkpVIGV 218
Cdd:cd01563 1 LWRYRELLP-VTEDDIVSLGEGNTPLVRAPRLGER-LGGKNLYVKDEGLNPTGSFKDRGMTVAVSKAKELG-----VKAV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 219 GCASTGDTSAALSAYCASAGIPSIVFLPADKiSMAQLVQPIANGAFVLSIDTDFDGCMHLIREVTAELPIYLANSLNSLR 298
Cdd:cd01563 74 ACASTGNTSASLAAYAARAGIKCVVFLPAGK-ALGKLAQALAYGATVLAVEGNFDDALRLVRELAEENWIYLSNSLNPYR 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 299 LEGQKTAAIEILQQFNWQVPDWVIVPGGNLGNIYAFYKGFHMCKELGLVDRIPRLVCAQAANANPLYLHYKSGfKEDFNP 378
Cdd:cd01563 153 LEGQKTIAFEIAEQLGWEVPDYVVVPVGNGGNITAIWKGFKELKELGLIDRLPRMVGVQAEGAAPIVRAFKEG-KDDIEP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 379 LKANTTFASAIQIGDPVSIDRAVYALKKSNGIVEEATEEELMDATALADST-GMFICPHTGVALTALMKLRKSGVIGAND 457
Cdd:cd01563 232 VENPETIATAIRIGNPASGPKALRAVRESGGTAVAVSDEEILEAQKLLARTeGIFVEPASAASLAGLKKLREEGIIDKGE 311
|
330
....*....|...
gi 18410191 458 RTVVVSTAHGLKF 470
Cdd:cd01563 312 RVVVVLTGHGLKD 324
|
|
| ThrC |
COG0498 |
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the ... |
125-509 |
1.14e-139 |
|
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the Pathway/BioSystem: Threonine biosynthesis
Pssm-ID: 440264 [Multi-domain] Cd Length: 394 Bit Score: 408.05 E-value: 1.14e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 125 SRVGKTNWPYGSGVWSKKEWvLPEIDDDDIVSAFEGNSNLFWAERFGKQYlqMNDLWVKHCGISHTGSFKDLGMSVLVSq 204
Cdd:COG0498 31 PALSREDLASRRGLWRYREL-LPFDDEEKAVSLGEGGTPLVKAPRLADEL--GKNLYVKEEGHNPTGSFKDRAMQVAVS- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 205 vnRLRKMNKPVIGvgCASTGDTSAALSAYCASAGIPSIVFLPADKISMAQLVQPIANGAFVLSIDTDFDGCMHLIREVTA 284
Cdd:COG0498 107 --LALERGAKTIV--CASSGNGSAALAAYAARAGIEVFVFVPEGKVSPGQLAQMLTYGAHVIAVDGNFDDAQRLVKELAA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 285 ELPIYLANSLNSLRLEGQKTAAIEILQQFNwQVPDWVIVPGGNLGNIYAFYKGFHMCKELGLVDRIPRLVCAQAANANPL 364
Cdd:COG0498 183 DEGLYAVNSINPARLEGQKTYAFEIAEQLG-RVPDWVVVPTGNGGNILAGYKAFKELKELGLIDRLPRLIAVQATGCNPI 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 365 YLHYKSGfKEDFNPLKANTTfASAIQIGDPVSIDRAVYALKKSNGIVEEATEEELMDATA-LADSTGMFICPHTGVALTA 443
Cdd:COG0498 262 LTAFETG-RDEYEPERPETI-APSMDIGNPSNGERALFALRESGGTAVAVSDEEILEAIRlLARREGIFVEPATAVAVAG 339
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18410191 444 LMKLRKSGVIGANDRTVVVSTAHGLKFTQSKIDYHSKNikemacrlanpPVKVKAKFGSVMDVLKE 509
Cdd:COG0498 340 LRKLREEGEIDPDEPVVVLSTGHGLKFPDAVREALGGE-----------PLAVPPDLEAVKAAVEE 394
|
|
| thrC |
TIGR00260 |
threonine synthase; Involved in threonine biosynthesis it catalyses the reaction ... |
138-469 |
3.86e-82 |
|
threonine synthase; Involved in threonine biosynthesis it catalyses the reaction O-PHOSPHO-L-HOMOSERINE + H(2)O = L-THREONINE + ORTHOPHOSPHATE using pyridoxal phosphate as a cofactor. the enzyme is distantly related to the serine/threonine dehydratases which are also pyridoxal-phosphate dependent enzymes. the pyridoxal-phosphate binding site is a Lys (K) residues present at residue 70 of the model. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 272986 [Multi-domain] Cd Length: 327 Bit Score: 258.47 E-value: 3.86e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 138 VWSKKEwVLPEIDDDdIVSAFEGNSNLFWAERFGKQyLQMNDLWVKHCGISHTGSFKDLGMSVLVSQVNRLRkmnkpVIG 217
Cdd:TIGR00260 1 VWRYRE-FLPVTEKD-LVDLGEGVTPLFRAPALAAN-VGIKNLYVKELGHNPTLSFKDRGMAVALTKALELG-----NDT 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 218 VGCASTGDTSAALSAYCASAGIPSIVFLPADKISMAQLVQPIANGAFVLSIDTDFDGCMHLIREVTAELPIYLANSLNSL 297
Cdd:TIGR00260 73 VLCASTGNTGAAAAAYAGKAGLKVVVLYPAGKISLGKLAQALGYNAEVVAIDGNFDDAQRLVKQLFEDKPALGLNSANSI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 298 --RLEGQKTAAIEILQQFNWQVPDWVIVPGGNLGNIYAFYKGFHMCKELGLvDRIPRLVCAQAANANPLYLHYKSGfkED 375
Cdd:TIGR00260 153 pyRLEGQKTYAFEAVEQLGWEAPDKVVVPVPNSGNFGAIWKGFKEKKMLGL-DSLPVKRGIQAEGAADIVRAFLEG--GQ 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 376 FNPLKANTTFASAIQIGDPVSIDRAVYALKKSNGIVEEATEEELMDATA-LADSTGMFICPHTGVALTALMKLRKSGVIG 454
Cdd:TIGR00260 230 WEPIETPETLSTAMDIGNPANWPRALEAFRRSNGYAEDLSDEEILEAIKlLAREEGYFVEPHSAVAVAALLKLVEKGTAD 309
|
330
....*....|....*
gi 18410191 455 ANDRTVVVSTAHGLK 469
Cdd:TIGR00260 310 PAERVVCALTGNGLK 324
|
|
| Trp-synth-beta_II |
cd00640 |
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP) ... |
164-466 |
2.91e-56 |
|
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan synthase beta chain (Trp-synth_B), cystathionine beta-synthase (CBS), O-acetylserine sulfhydrylase (CS), serine dehydratase (Ser-dehyd), threonine dehydratase (Thr-dehyd), diaminopropionate ammonia lyase (DAL), and threonine synthase (Thr-synth). ACCD catalyzes the conversion of 1-aminocyclopropane-1-carboxylate to alpha-ketobutyrate and ammonia. Tryptophan synthase folds into a tetramer, where the beta chain is the catalytic PLP-binding subunit and catalyzes the formation of L-tryptophan from indole and L-serine. CBS is a tetrameric hemeprotein that catalyzes condensation of serine and homocysteine to cystathionine. CS is a homodimer that catalyzes the formation of L-cysteine from O-acetyl-L-serine. Ser-dehyd catalyzes the conversion of L- or D-serine to pyruvate and ammonia. Thr-dehyd is active as a homodimer and catalyzes the conversion of L-threonine to 2-oxobutanoate and ammonia. DAL is also a homodimer and catalyzes the alpha, beta-elimination reaction of both L- and D-alpha, beta-diaminopropionate to form pyruvate and ammonia. Thr-synth catalyzes the formation of threonine and inorganic phosphate from O-phosphohomoserine.
Pssm-ID: 107202 [Multi-domain] Cd Length: 244 Bit Score: 188.11 E-value: 2.91e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 164 LFWAERFGKQYLqmNDLWVKHCGISHTGSFKDLGMSVLVSQVNRLRKMNKPVIGvgCASTGDTSAALSAYCASAGIPSIV 243
Cdd:cd00640 3 LVRLKRLSKLGG--ANIYLKLEFLNPTGSFKDRGALNLILLAEEEGKLPKGVII--ESTGGNTGIALAAAAARLGLKCTI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 244 FLPADKiSMAQLVQPIANGAFVLSIDTDFDGCMHLIREVTAELP-IYLANS-LNSLRLEGQKTAAIEILQQFNWQVPDWV 321
Cdd:cd00640 79 VMPEGA-SPEKVAQMRALGAEVVLVPGDFDDAIALAKELAEEDPgAYYVNQfDNPANIAGQGTIGLEILEQLGGQKPDAV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 322 IVPGGNLGNIYAFYKGFhmcKELGlvdRIPRLVCAQAananplylhyksgfkedfnplkanttfasaiqigdpvsidrav 401
Cdd:cd00640 158 VVPVGGGGNIAGIARAL---KELL---PNVKVIGVEP------------------------------------------- 188
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18410191 402 yalkksngIVEEATEEELMDAT-ALADSTGMFICPHTGVALTALMKLRKSGviGANDRTVVVSTAH 466
Cdd:cd00640 189 --------EVVTVSDEEALEAIrLLAREEGILVEPSSAAALAAALKLAKKL--GKGKTVVVILTGG 244
|
|
| PRK08197 |
PRK08197 |
threonine synthase; Validated |
85-470 |
1.00e-55 |
|
threonine synthase; Validated
Pssm-ID: 181283 [Multi-domain] Cd Length: 394 Bit Score: 191.37 E-value: 1.00e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 85 ESYSLDEIVYRSQSGALLDVQHDFAALKRydgEFWRNLFDSRvGKTNWPYGSgvwskkewVLPEIDDDDIVSAFEGNSNL 164
Cdd:PRK08197 15 ETYDADQVHNLCKCGKPLLVRYDLEAVKQ---AVTREALAGR-PANLWRYHE--------LLPVRDPEHIVSLGEGMTPL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 165 FWAERFGKQyLQMNDLWVKHCGISHTGSFKDLGMSVLVSQVNRLRkmnkpVIGVGCASTGDTSAALSAYCASAGIPSIVF 244
Cdd:PRK08197 83 LPLPRLGKA-LGIGRLWVKDEGLNPTGSFKARGLAVGVSRAKELG-----VKHLAMPTNGNAGAAWAAYAARAGIRATIF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 245 LPADkISMAQLVQPIANGAFVLSIDTDFDGCMHLIREVTAELPIYLANSLNS-LRLEGQKTAAIEILQQFNWQVPDWVIV 323
Cdd:PRK08197 157 MPAD-APEITRLECALAGAELYLVDGLISDAGKIVAEAVAEYGWFDVSTLKEpYRIEGKKTMGLELAEQLGWRLPDVILY 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 324 P-GGNLGNIyAFYKGFHMCKELGLVD-RIPRLVCAQAANANPLYLHYKSGfKEDFNPLKANTTFASAIQIgdPVSI-DRA 400
Cdd:PRK08197 236 PtGGGVGLI-GIWKAFDELEALGWIGgKRPRLVAVQAEGCAPIVKAWEEG-KEESEFWEDAHTVAFGIRV--PKALgDFL 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18410191 401 VY-ALKKSNGIVEEATEEELMDATA-LADSTGMFICPHTGVALTALMKLRKSGVIGANDRTVVVSTAHGLKF 470
Cdd:PRK08197 312 VLdAVRETGGCAIAVSDDAILAAQReLAREEGLFACPEGAATFAAARQLRESGWLKGDERVVLFNTGSGLKY 383
|
|
| PALP |
pfam00291 |
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ... |
155-464 |
3.20e-54 |
|
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.
Pssm-ID: 459749 [Multi-domain] Cd Length: 295 Bit Score: 184.44 E-value: 3.20e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 155 VSAFEGNSNLFWAERFGKQYLQmnDLWVKHCGISHTGSFKDLGMSVLVSQVNRlrkmNKPVIGVGCASTGDTSAALSAYC 234
Cdd:pfam00291 1 ISLGIGPTPLVRLPRLSKELGV--DVYLKLESLNPTGSFKDRGALNLLLRLKE----GEGGKTVVEASSGNHGRALAAAA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 235 ASAGIPSIVFLPAD----KISMAQLVqpianGAFVLSIDTDFDGCMHLIREVTAELP--IYLANSLNSLRLEGQKTAAIE 308
Cdd:pfam00291 75 ARLGLKVTIVVPEDappgKLLLMRAL-----GAEVVLVGGDYDEAVAAARELAAEGPgaYYINQYDNPLNIEGYGTIGLE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 309 ILQQFNwQVPDWVIVPGGNLGNIYAFYKGFhmcKELGlvdRIPRLVCAQAANANPLylhYKSGFKEDFNPLKANTTFASA 388
Cdd:pfam00291 150 ILEQLG-GDPDAVVVPVGGGGLIAGIARGL---KELG---PDVRVIGVEPEGAPAL---ARSLAAGRPVPVPVADTIADG 219
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18410191 389 IQIGDPVSiDRAVYALKKSNGIVEEATEEELMDATA-LADSTGMFICPHTGVALTALmKLRKSGVIGANDRTVVVST 464
Cdd:pfam00291 220 LGVGDEPG-ALALDLLDEYVGEVVTVSDEEALEAMRlLARREGIVVEPSSAAALAAL-KLALAGELKGGDRVVVVLT 294
|
|
| PRK05638 |
PRK05638 |
threonine synthase; Validated |
91-469 |
2.72e-48 |
|
threonine synthase; Validated
Pssm-ID: 235539 [Multi-domain] Cd Length: 442 Bit Score: 172.69 E-value: 2.72e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 91 EIVYRSQSGALLDVQHDFAALkryDGEFWRNlfdsrvgktnwpYGSGVWSKKEwVLPEIDDddIVSAFEGNSNLFWA--- 167
Cdd:PRK05638 14 YIPPFCICGELLEIIYDYSSV---DVRKWKN------------RDPGVWRYKE-LLPQVKK--IISLGEGGTPLIRAris 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 168 ERFGKqylqmnDLWVKHCGISHTGSFKDLGMSVLVSqvNRLRKMNKPVIgvgCASTGDTSAALSAYCASAGIPSIVFLPA 247
Cdd:PRK05638 76 EKLGE------NVYIKDETRNPTGSFRDRLATVAVS--YGLPYAANGFI---VASDGNAAASVAAYSARAGKEAFVVVPR 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 248 dKISMAQLVQPIANGAFVLSIDTDFDGCMHLIREVTAELPIYLANSL-NSLRLEGQKTAAIEILQQFNwqvPDWVIVPGG 326
Cdd:PRK05638 145 -KVDKGKLIQMIAFGAKIIRYGESVDEAIEYAEELARLNGLYNVTPEyNIIGLEGQKTIAFELWEEIN---PTHVIVPTG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 327 NLGNIYAFYKGFHMCKELGLVDRIPRLVCAQAANANPLYLHYKSgfkedfNPLKANTTFASAIQIGDPVSIDRAVYALKK 406
Cdd:PRK05638 221 SGSYLYSIYKGFKELLEIGVIEEIPKLIAVQTERCNPIASEILG------NKTKCNETKALGLYVKNPVMKEYVSEAIKE 294
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18410191 407 SNGIVEEATEEELMDATALADSTGMFICPHTGVALTALMKLRKSGVIGANDRTVVVSTAHGLK 469
Cdd:PRK05638 295 SGGTAVVVNEEEIMAGEKLLAKEGIFAELSSAVVMPALLKLGEEGYIEKGDKVVLVVTGSGLK 357
|
|
| PRK08329 |
PRK08329 |
threonine synthase; Validated |
190-469 |
1.10e-26 |
|
threonine synthase; Validated
Pssm-ID: 236244 [Multi-domain] Cd Length: 347 Bit Score: 110.69 E-value: 1.10e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 190 TGSFKDLGMSVLVSQVNRLrKMNKPVIGvgcaSTGDTSAALSAYCASAGIPSIVFLPAD----KISMAQLVqpianGAFV 265
Cdd:PRK08329 84 TGSFKDRGTYVTVAKLKEE-GINEVVID----SSGNAALSLALYSLSEGIKVHVFVSYNaskeKISLLSRL-----GAEL 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 266 LSIDTDFdgcMHLIREVTA----ELPIYLANSLNSLRLEGQKTAAIEILQQFNwqVPDWVIVPGGNLGNIYAFYKGFHMC 341
Cdd:PRK08329 154 HFVEGDR---MEVHEEAVKfskrNNIPYVSHWLNPYFLEGTKTIAYEIYEQIG--VPDYAFVPVGSGTLFLGIWKGFKEL 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 342 KELGLVDRIPRLVCAQAananplylhykSGFKEDFNPLKANTTFASAIQIGDPVSIDRAVYALKKSNGIVEEATEEELMD 421
Cdd:PRK08329 229 HEMGEISKMPKLVAVQA-----------EGYESLCKRSKSENKLADGIAIPEPPRKEEMLRALEESNGFCISVGEEETRA 297
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 18410191 422 ATALADSTGMFICPHTGVALTALMKLRKSGVIGANDRTVVVSTAHGLK 469
Cdd:PRK08329 298 ALHWLRRMGFLVEPTSAVALAAYWKLLEEGLIEGGSKVLLPLSGSGLK 345
|
|
| Thr-synth_2 |
cd01560 |
Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of ... |
190-505 |
1.45e-23 |
|
Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, archaebacteria and eubacterial groups. This CD, Thr-synth_2, includes enzymes from fungi and eubacterial groups, as well as, metazoan threonine synthase-like proteins.
Pssm-ID: 107203 [Multi-domain] Cd Length: 460 Bit Score: 103.47 E-value: 1.45e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 190 TGSFKDLGMSVLVSQVNR-LRKMNKPVIGVGcASTGDT-SAALSAYcasAGIPSI---VFLPADKIS---MAQLV-QPIA 260
Cdd:cd01560 107 TLAFKDMALQFLGRLLEYfLKRRNERITILV-ATSGDTgSAAIEGF---RGKPNVdvvVLYPKGGVSpiqELQMTtLPAD 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 261 NGaFVLSIDTDFDGCMHLIREVTAE------LPIYLANSLNSLRLEGQKT----AAIEILQQFNWQVPDwVIVPGGNLGN 330
Cdd:cd01560 183 NV-HVVAVEGDFDDCQSLVKALFADedfnkkLKLSSANSINWARILAQIVyyfyAYLQLLKRGEGEKVE-FSVPTGNFGN 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 331 IYAFYkgfhMCKELGLvdRIPRLVCAQAANaNPLYLHYKSGfkeDFNP---LKAntTFASAIQIGDPVSIDRAVYAL--- 404
Cdd:cd01560 261 ILAGY----YAKKMGL--PIKKLIVATNEN-DVLRRFFKTG---RYDRresLKQ--TLSPAMDILKSSNFERLLFLLagr 328
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 405 --------------------------KKSNGIV-EEATEEELMDATA-LADSTGMFICPHTGVALTALMKLRKSgvigAN 456
Cdd:cd01560 329 drtkvkmlmeefeatgflslpkeelkKLREDFSsGSVSDEETLETIReVYEETGYLIDPHTAVGVRAAERVRKS----PG 404
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 18410191 457 DRTVVVSTAHGLKFTQSkidyhsknIKEMacrLANPPVKVKAKFGSVMD 505
Cdd:cd01560 405 TPGVVLSTAHPAKFPEA--------VKEA---LGEEPVELPEELEGLED 442
|
|
| PRK06450 |
PRK06450 |
threonine synthase; Validated |
99-469 |
1.81e-23 |
|
threonine synthase; Validated
Pssm-ID: 180565 [Multi-domain] Cd Length: 338 Bit Score: 101.35 E-value: 1.81e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 99 GALLDVQHDFaalkrydgEFWRNLfdsrvGKTNWPYgsgvwsKKEWVlpeiddddivSAFEGNSNLFwaerfgkqylQMN 178
Cdd:PRK06450 25 GGPFEILIDF--------EFDKNL-----ERKNFPY------IKHFI----------SLGEGRTPLI----------KKG 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 179 DLWVKHCGISHTGSFKDLGMSVLVSQVNRLRkmnkpVIGVGCASTGDTSAALSAYCASAGIPSIVFLPaDKISMAQLVQP 258
Cdd:PRK06450 66 NIWFKLDFLNPTGSYKDRGSVTLISYLAEKG-----IKQISEDSSGNAGASIAAYGAAAGIEVKIFVP-ETASGGKLKQI 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 259 IANGAFVLSIDTDFDgcmhlirEVTAELP----IYLANSLNSLRLEGQKTAAIEILQQFNWQVPDWVIVP--GGNLgnIY 332
Cdd:PRK06450 140 ESYGAEVVRVRGSRE-------DVAKAAEnsgyYYASHVLQPQFRDGIRTLAYEIAKDLDWKIPNYVFIPvsAGTL--LL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 333 AFYKGFHMCKELGLVDRIPRLVCAQAANANPLYLHYKsgfKEDFNPLKANTTFASAIQIGDPVSIDRAVYALKKsNGIVE 412
Cdd:PRK06450 211 GVYSGFKHLLDSGVISEMPKIVAVQTEQVSPLCAKFK---GISYTPPDKVTSIADALVSTRPFLLDYMVKALSE-YGECI 286
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 18410191 413 EATEEELMDATALADSTGMFICPHTGVALTALMKLRKsgviganDRTVVVSTAHGLK 469
Cdd:PRK06450 287 VVSDNEIVEAWKELAKKGLLVEYSSATVYAAYKKYSV-------NDSVLVLTGSGLK 336
|
|
| PRK06381 |
PRK06381 |
threonine synthase; Validated |
160-464 |
1.19e-22 |
|
threonine synthase; Validated
Pssm-ID: 235789 Cd Length: 319 Bit Score: 98.62 E-value: 1.19e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 160 GNSNLFWAERFGKqYLQMNDLWVKHCGISHTGSFKDLGMSVLVSQVNRLrKMNkpviGVGCASTGDTSAALSAYCASAGI 239
Cdd:PRK06381 14 GGTPLLRARKLEE-ELGLRKIYLKFEGANPTGTQKDRIAEAHVRRAMRL-GYS----GITVGTCGNYGASIAYFARLYGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 240 PSIVFLPAdKISMAQLVQPIANGAFVLSIDTDFDGCMHLIREVTAELPIYLAN--SLNS-LRLEGQKTAAIEILQQFNwQ 316
Cdd:PRK06381 88 KAVIFIPR-SYSNSRVKEMEKYGAEIIYVDGKYEEAVERSRKFAKENGIYDANpgSVNSvVDIEAYSAIAYEIYEALG-D 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 317 VPDWVIVPGGNLGNIYAFYKGFHMCKELGLVDRIPRLVCAQAANANPLYLHYKSGFKE--DFNPLKANTTfasaiQIGDP 394
Cdd:PRK06381 166 VPDAVAVPVGNGTTLAGIYHGFRRLYDRGKTSRMPRMIGVSTSGGNQIVESFKRGSSEvvDLEVDEIRET-----AVNEP 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18410191 395 -VSI-----DRAVYALKKSNGIVEEATEEELMD-ATALADSTGMFICPHTGVALTALMKLRKSGviGANDRTVVVST 464
Cdd:PRK06381 241 lVSYrsfdgDNALEAIYDSHGYAFGFSDDEMVKyAELLRRMEGLNALPASASALAALVKYLKKN--GVNDNVVAVIT 315
|
|
| Thr-dehyd |
cd01562 |
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. ... |
168-462 |
1.72e-11 |
|
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly converted into NH4+. The direct deamination is catalyzed by threonine dehydratase, in which pyridoxal phosphate (PLP) is the prosthetic group. Threonine dehydratase is widely distributed in all three major phylogenetic divisions.
Pssm-ID: 107205 [Multi-domain] Cd Length: 304 Bit Score: 65.20 E-value: 1.72e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 168 ERFGKQ-YLQMNDLwvkhcgiSHTGSFKDLGMSVLVSQvnrLRKMNKPViGVGCASTGDTSAALSAYCASAGIPSIVFLP 246
Cdd:cd01562 28 ELLGAEvYLKCENL-------QKTGSFKIRGAYNKLLS---LSEEERAK-GVVAASAGNHAQGVAYAAKLLGIPATIVMP 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 247 AD----KISMAQlvqpiANGAFVLSIDTDFDGCMHLIREVTAELPIYLANSLNSLR-LEGQKTAAIEILQqfnwQVP--D 319
Cdd:cd01562 97 ETapaaKVDATR-----AYGAEVVLYGEDFDEAEAKARELAEEEGLTFIHPFDDPDvIAGQGTIGLEILE----QVPdlD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 320 WVIVP---GGNLGNIYAFYKGFHmckelglvdriP--RLVCAQAANANPLYLHYKSGFKEdfnPLKANTTFASAIQIGDP 394
Cdd:cd01562 168 AVFVPvggGGLIAGIATAVKALS-----------PntKVIGVEPEGAPAMAQSLAAGKPV---TLPEVDTIADGLAVKRP 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18410191 395 vsiDRAVYALKKSN--GIVeEATEEELMDATALADSTGMFICPHTG-VALTALMklrkSGVIGANDRTVVV 462
Cdd:cd01562 234 ---GELTFEIIRKLvdDVV-TVSEDEIAAAMLLLFEREKLVAEPAGaLALAALL----SGKLDLKGKKVVV 296
|
|
| IlvA |
COG1171 |
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the ... |
167-462 |
8.78e-08 |
|
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440784 [Multi-domain] Cd Length: 327 Bit Score: 53.89 E-value: 8.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 167 AERFGkqylqmNDLWVKHCGISHTGSFKDLGMSVLVSQVNRlrkmNKPVIGVGCASTGDTSAALsAYCASA-GIPSIVFL 245
Cdd:COG1171 34 SERLG------AEVYLKLENLQPTGSFKLRGAYNALASLSE----EERARGVVAASAGNHAQGV-AYAARLlGIPATIVM 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 246 PAD----KISMAQlvqpiANGAFVLSIDTDFDGCMHLIREVTAElpiylanslNSLRL----------EGQKTAAIEILQ 311
Cdd:COG1171 103 PETapavKVAATR-----AYGAEVVLHGDTYDDAEAAAAELAEE---------EGATFvhpfddpdviAGQGTIALEILE 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 312 QfnWQVPDWVIVP--GGNL--GNIYAFykgfhmcKELGlvDRIpRLVCAQAANANPLYLHYKSGFKEDfnpLKANTTFAS 387
Cdd:COG1171 169 Q--LPDLDAVFVPvgGGGLiaGVAAAL-------KALS--PDI-RVIGVEPEGAAAMYRSLAAGEPVT---LPGVDTIAD 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18410191 388 AIQIGDPVSIDRAVyALKKSNGIVeEATEEELMDATA-LADSTGMfICPHTG-VALTALMKLRksgvIGANDRTVVV 462
Cdd:COG1171 234 GLAVGRPGELTFEI-LRDLVDDIV-TVSEDEIAAAMRlLLERTKI-VVEPAGaAALAALLAGK----ERLKGKRVVV 303
|
|
| PRK06815 |
PRK06815 |
threonine/serine dehydratase; |
179-328 |
1.60e-06 |
|
threonine/serine dehydratase;
Pssm-ID: 180709 [Multi-domain] Cd Length: 317 Bit Score: 50.08 E-value: 1.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 179 DLWVKHCGISHTGSFKDLGMSvlvsqvNRLRKMNKPV--IGVGCASTGDTSAALSAYCASAGIPSIVFLPADkISMAQLV 256
Cdd:PRK06815 36 EVYLKCEHLQHTGSFKFRGAS------NKLRLLNEAQrqQGVITASSGNHGQGVALAAKLAGIPVTVYAPEQ-ASAIKLD 108
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18410191 257 QPIANGAFVLSIDTDFDGC-MHLIREVTAELPIYLANSLNSLRLEGQKTAAIEILQqfnwQVPD----WVIVPGGNL 328
Cdd:PRK06815 109 AIRALGAEVRLYGGDALNAeLAARRAAEQQGKVYISPYNDPQVIAGQGTIGMELVE----QQPDldavFVAVGGGGL 181
|
|
| PRK08246 |
PRK08246 |
serine/threonine dehydratase; |
180-337 |
2.37e-06 |
|
serine/threonine dehydratase;
Pssm-ID: 181319 [Multi-domain] Cd Length: 310 Bit Score: 49.57 E-value: 2.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 180 LWVKHCGISHTGSFKDLGMsvlvsqVNRLRKMNKPVIGVGCASTGDTSAALSAYCASAGIPSIVFLPAdkISMAQLVQPI 259
Cdd:PRK08246 39 VWLKLEHLQHTGSFKARGA------FNRLLAAPVPAAGVVAASGGNAGLAVAYAAAALGVPATVFVPE--TAPPAKVARL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 260 -ANGAFVLSIDTDFDGCMHLIREVTAE---LPIYLANslNSLRLEGQKTAAIEILQqfnwQVPD----WVIVPGGNL-GN 330
Cdd:PRK08246 111 rALGAEVVVVGAEYADALEAAQAFAAEtgaLLCHAYD--QPEVLAGAGTLGLEIEE----QAPGvdtvLVAVGGGGLiAG 184
|
....*..
gi 18410191 331 IYAFYKG 337
Cdd:PRK08246 185 IAAWFEG 191
|
|
| PRK08813 |
PRK08813 |
threonine dehydratase; Provisional |
164-427 |
3.77e-05 |
|
threonine dehydratase; Provisional
Pssm-ID: 236339 [Multi-domain] Cd Length: 349 Bit Score: 45.77 E-value: 3.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 164 LFWAERFGkqylqmndLWVKHCGISHTGSFKDLG-MSVLVsqVNRLRKMNKPVIgvgCASTGDTS--AALSAYcaSAGIP 240
Cdd:PRK08813 42 LHYAERFG--------VWLKLENLQRTGSYKVRGaLNALL--AGLERGDERPVI---CASAGNHAqgVAWSAY--RLGVQ 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 241 SIVFLP--ADKISMAQLVQPianGAFVLSIDTDFDGCMHLIREVTAELPIYLANSLNSLR-LEGQKTAAIEILQqfnwQV 317
Cdd:PRK08813 107 AITVMPhgAPQTKIAGVAHW---GATVRQHGNSYDEAYAFARELADQNGYRFLSAFDDPDvIAGQGTVGIELAA----HA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 318 PDWVIVP--GGNLGNIYAfykgfhmckeLGLVDRIPRLVCAQAANANPLylhyKSGFKEDFNPLKANTTFASAIQIGDPV 395
Cdd:PRK08813 180 PDVVIVPigGGGLASGVA----------LALKSQGVRVVGAQVEGVDSM----ARAIRGDLREIAPVATLADGVKVKIPG 245
|
250 260 270
....*....|....*....|....*....|...
gi 18410191 396 SIDRAVYA-LKKSNGIVEEATEEELMDATALAD 427
Cdd:PRK08813 246 FLTRRLCSsLLDDVVIVREAELRETLVRLALEE 278
|
|
| PRK08639 |
PRK08639 |
threonine dehydratase; Validated |
163-328 |
5.10e-04 |
|
threonine dehydratase; Validated
Pssm-ID: 236318 [Multi-domain] Cd Length: 420 Bit Score: 42.49 E-value: 5.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 163 NLFWAERFGKQ-YLQMNDL-WVKhcgishtgSFKDLGMSVLVSQVNRLRKMNkpviGVGCASTGDtSAALSAY-CASAGI 239
Cdd:PRK08639 31 NDYLSEKYGANvYLKREDLqPVR--------SYKLRGAYNAISQLSDEELAA----GVVCASAGN-HAQGVAYaCRHLGI 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410191 240 PSIVFLPA-------DKISM--AQLVQPIANGafvlsiDTdFDGCMHLIREVTAELPIYLANSLNSLR-LEGQKTAAIEI 309
Cdd:PRK08639 98 PGVIFMPVttpqqkiDQVRFfgGEFVEIVLVG------DT-FDDSAAAAQEYAEETGATFIPPFDDPDvIAGQGTVAVEI 170
|
170 180
....*....|....*....|..
gi 18410191 310 LQQFNWQ-VPDWVIVP--GGNL 328
Cdd:PRK08639 171 LEQLEKEgSPDYVFVPvgGGGL 192
|
|
| |
