uncharacterized protein AT1G73380 [Arabidopsis thaliana]
Protein Classification
DUF1308 domain-containing protein( domain architecture ID 68660)
DUF1308 domain-containing protein similar to Homo sapiens protein C7orf25
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| DUF1308 super family | cl15654 | Protein of unknown function (DUF1308); This is a domain of unknown function found on the ... |
266-432 | 1.61e-32 | ||||
Protein of unknown function (DUF1308); This is a domain of unknown function found on the C-terminal of C7orf25 protein UPF0415. The C-terminal domain is homologous to the known PIN-like domains. The PIN-like domain is widespread among eukaryotes, including animals, plants, and fungi, but also present in some cyanobacteria, Deinococcus, and dsDNA viruses from the Mimiviridae family. The domain retains up to four potential catalytic residues, thus, depending on the protein is predicted to be an active or inactive nuclease and in a majority of the family members, the PIN-like domain is N-terminally fused with a potentially active PD-(D/E)XK-like domain pfam18474. The actual alignment was detected with superfamily member pfam07000: Pssm-ID: 399767 Cd Length: 163 Bit Score: 120.83 E-value: 1.61e-32
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| Name | Accession | Description | Interval | E-value | ||||
| DUF1308 | pfam07000 | Protein of unknown function (DUF1308); This is a domain of unknown function found on the ... |
266-432 | 1.61e-32 | ||||
Protein of unknown function (DUF1308); This is a domain of unknown function found on the C-terminal of C7orf25 protein UPF0415. The C-terminal domain is homologous to the known PIN-like domains. The PIN-like domain is widespread among eukaryotes, including animals, plants, and fungi, but also present in some cyanobacteria, Deinococcus, and dsDNA viruses from the Mimiviridae family. The domain retains up to four potential catalytic residues, thus, depending on the protein is predicted to be an active or inactive nuclease and in a majority of the family members, the PIN-like domain is N-terminally fused with a potentially active PD-(D/E)XK-like domain pfam18474. Pssm-ID: 399767 Cd Length: 163 Bit Score: 120.83 E-value: 1.61e-32
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| PIN_VapC_C-like | cd18698 | VapC-like C-terminus of DUF1308 domain in DUF1308 domain-containing proteins and related ... |
327-407 | 5.10e-03 | ||||
VapC-like C-terminus of DUF1308 domain in DUF1308 domain-containing proteins and related proteins; This subfamily includes the C-terminus of DUF1308 domain in DUF1308 domain-containing proteins, and is an uncharacterized subfamily of the VapC (virulence-associated protein C)-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons. Pssm-ID: 350265 Cd Length: 138 Bit Score: 37.36 E-value: 5.10e-03
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| Name | Accession | Description | Interval | E-value | ||||
| DUF1308 | pfam07000 | Protein of unknown function (DUF1308); This is a domain of unknown function found on the ... |
266-432 | 1.61e-32 | ||||
Protein of unknown function (DUF1308); This is a domain of unknown function found on the C-terminal of C7orf25 protein UPF0415. The C-terminal domain is homologous to the known PIN-like domains. The PIN-like domain is widespread among eukaryotes, including animals, plants, and fungi, but also present in some cyanobacteria, Deinococcus, and dsDNA viruses from the Mimiviridae family. The domain retains up to four potential catalytic residues, thus, depending on the protein is predicted to be an active or inactive nuclease and in a majority of the family members, the PIN-like domain is N-terminally fused with a potentially active PD-(D/E)XK-like domain pfam18474. Pssm-ID: 399767 Cd Length: 163 Bit Score: 120.83 E-value: 1.61e-32
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| PIN_VapC_C-like | cd18698 | VapC-like C-terminus of DUF1308 domain in DUF1308 domain-containing proteins and related ... |
327-407 | 5.10e-03 | ||||
VapC-like C-terminus of DUF1308 domain in DUF1308 domain-containing proteins and related proteins; This subfamily includes the C-terminus of DUF1308 domain in DUF1308 domain-containing proteins, and is an uncharacterized subfamily of the VapC (virulence-associated protein C)-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons. Pssm-ID: 350265 Cd Length: 138 Bit Score: 37.36 E-value: 5.10e-03
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