|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
115-539 |
1.03e-101 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 313.73 E-value: 1.03e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 115 QMKEIVMFTGPAAGLWLCGPLMSLIDTAVIGQ-GSSLELAALGPATVICDYLCYTFMFLSVATSNLVATSLARQDKDEVQ 193
Cdd:cd13136 1 LHREILALALPAILSNITVPLLGLVDTAVVGHlGSAAYLGAVALGTTIFNTLFWLFGFLRMGTTGLVAQALGAGDREEAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 194 HQISILLFIGLACGVTMMVLTRLFGSWALTAFTGvkNADIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKA 273
Cdd:cd13136 81 ALLVRALLLALAIGLLLILLQSPLLALALLLLGA--SAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLIL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 274 LAVASAINGVGDVVLCTFLGYGIAGAAWATMVSQVVAAYMMMDALNKKGY---SAFSFCVPSPSELLTIFGLAAPVFITM 350
Cdd:cd13136 159 QIVGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRRRVRllgKSLSRRLPSKAALKRLFKLNRDIFIRT 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 351 MSKVLFYTLLVYFATSMGTNIIAAHQVMLQIYTMSTVWGEPLSQTAQSFmPELLFGInRNLPKARVLLKSLVIIGATLGI 430
Cdd:cd13136 239 LALLAAFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEAL-VGRALGA-GDRKAARRVARRLLQWGLGLGV 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 431 VVGTIGTAVPWLFPGIFTRDKVVTSEMHKVIIPYFLALSITPSTHSLEGTLLAGRDLRYISLSMTGCLAVAGLLLMLLSn 510
Cdd:cd13136 317 LLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNSMLVSLAVFLPLLFLLV- 395
|
410 420
....*....|....*....|....*....
gi 240254500 511 GGFGLRGCWYALVGFQWARFSLSLFRLLS 539
Cdd:cd13136 396 PLWGNHGLWLALILFMLLRGLTLALRLPR 424
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
116-536 |
1.96e-51 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 181.88 E-value: 1.96e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 116 MKEIVMFTGPAAGLWLCGPLMSLIDTAVIGQGSSLELAALGPATVICDYLCYTFMFLSVATSNLVATSLARQDKDEVQHQ 195
Cdd:COG0534 7 LKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDREEARRV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 196 ISILLFIGLACGVTMMVLTRLFGSWALTAFTGvkNADIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALA 275
Cdd:COG0534 87 LGQALLLALLLGLLLTLLGLLFAPPLLRLLGA--DPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIML 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 276 VASAINGVGDVVLCTFLGYGIAGAAWATMVSQVVAA-YMMMDALNKKGYSAFSF--CVPSPSELLTIFGLAAPVFITMMS 352
Cdd:COG0534 165 IGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSAlLLLYYLFRKRSLLRLRLrdLRPDRKILKRILRIGLPAGLQQLA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 353 KVLFYTLLVYFATSMGTNIIAAHQVMLQIYTMSTVWGEPLSQTAQSFMpellfGIN---RNLPKARVLLKSLVIIGATLG 429
Cdd:COG0534 245 ESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLV-----GQNlgaGDYDRARRAARLALLLALGIG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 430 IVVGTIGTAVPWLFPGIFTRDKVVTSEMHKVIIPYFLALSITPSTHSLEGTLLAGRDLRYISLSMTGCLAVAGLLLM-LL 508
Cdd:COG0534 320 LLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAyLL 399
|
410 420
....*....|....*....|....*...
gi 240254500 509 SNGGFGLRGCWYALVGFQWARFSLSLFR 536
Cdd:COG0534 400 AFLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
135-541 |
8.51e-31 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 124.55 E-value: 8.51e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 135 LMSLIDTAVIGQGSSLELAALGPATvicdyLCYTFMF-----LSVATSNLVATSLARQDKDEVQHQISILLFIGLACGVT 209
Cdd:cd13137 19 LVGLVDVFMVGRLGAEAIAAVGLAT-----QVLWLLLvlnmaLGTGTVALVSQSYGAGDYERARRALGQSLLLALLLSLP 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 210 MMVLTRLFGSWALTAFTGvkNADIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALAVASAINGVGDVVL- 288
Cdd:cd13137 94 LALLGLLFAEPLLRLLGA--DPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVNVLNIVLDYVLi 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 289 ---CTFLGYGIAGAAWATMVSQVVAAYMMMDALNKKGY---SAFSFCVPSPSELLTIFGLAAPVFITMMSKVLFYTLLVY 362
Cdd:cd13137 172 fglWGFPGLGVAGAALATVISRVVGALLLLFLLLRGRLpikISFKGFRLDRKIIKKLLRIGLPAGLEQLLRSLGFLVLLA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 363 FATSMGTNIIAAHQVMLQIYTMSTVWGEPLSQTAQSfmpelLFGIN---RNLPKARVLLKSLVIIGATLGIVVGTIGTAV 439
Cdd:cd13137 252 IVASYGTAALAAYQIGLRIESLAFMPGFGFSMAAST-----LVGQNlgaGDPDEARRYGKRALRLGVLFMGLLGLLLFIF 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 440 PWLFPGIFTRDKVVTSEMHKVIIPYFLALSITPSTHSLEGTLLAGRDLRYISLSMTGCLAVA--GLLLMLLSNGGFGLRG 517
Cdd:cd13137 327 APPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVrlPLAYLLGFVLGLGLTG 406
|
410 420
....*....|....*....|....
gi 240254500 518 CWYALVGFQWARFSLSLFRLLSRD 541
Cdd:cd13137 407 IWLAMFVDTIVRAILLLYRFRKGK 430
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
135-521 |
5.69e-26 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 110.63 E-value: 5.69e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 135 LMSLIDTAVIGQ-GSSLELAALGPATVICDYLCYTFMFLSVATSNLVATSLARQDKDEVQHQISILLFIGLACGVTMMVL 213
Cdd:cd13138 21 LYNLVDLLIVGQfLGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKKAVGTLLVLFLILGIVLTIL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 214 TRLFGSWALTAfTGVkNADIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALAVASAINGVGDVVLCTFLG 293
Cdd:cd13138 101 GLLFAPPILRL-MNT-PAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKTPLYFVIIACVLNIILDLLFIAVFH 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 294 YGIAGAAWATMVSQVVAAYMMMDALNKKGYSA---FSFCVPSPSELLTIFGLAAPVFITMMSKVLFYTLLVYFATSMGTN 370
Cdd:cd13138 179 MGVAGAALATVIAQAISVLLALYYLRKKKLPFklsLKDFRFDKEILKEILKIGLPSALQQSLVSISFLIINSIVNSYGVV 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 371 IIAAHQVMLQIYTMSTVWGEPLSQTAQSFMPELLfGiNRNLPKArvllKSLVIIGATLGIVVGTIGTAVPWLFP----GI 446
Cdd:cd13138 259 ASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNI-G-AGKIERA----KKGLRTGIIISLIIGLIIILLVFFFApqllGL 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 447 FTRDKVV---TSEMHKVIIPYFLALSItpsTHSLEGTLLA-GRDLRYISLSMTGCLAVAGLLLMLLSN-GGFGLRGCWYA 521
Cdd:cd13138 333 FTSDPEVieiGAEYLRIYSIDYILFGI---LFVFNGLFRGlGKTKFPMIISILRLWLVRIPLAYLLSRlTGLGLFGIWLA 409
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
125-455 |
4.20e-25 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 106.56 E-value: 4.20e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 125 PAAGLWLCGPLMSLIDTAVIGQGSSLELAALGPATVICDYLCYTFMFLSVATSNLVATSLARQDKDEVQHQISILLFIGL 204
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 205 ACGVTMMVLTRLFGSWALTAFTGvkNADIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALAVASAINGVG 284
Cdd:TIGR00797 81 LLGLPVLLVGYFFIDPLLSLMGA--DGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIIL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 285 DVVL--CTFLGYGIAGAAWATMVSQVVAAYMMMDALNKK---GYSAFSFCVPSPSELLTIFGLAAPVFITMMSKVLFYTL 359
Cdd:TIGR00797 159 NYILifGKFGFLGIVGAALATVISYWLMFLLLLYYIKKAkkiGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFAL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 360 LVYFATSMGTNIIAAHQVMLQIYTMSTVWGEPLSQTAQSFMPELLfGInRNLPKARVLLKSLVIIGATLGIVVGTIGTAV 439
Cdd:TIGR00797 239 LALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQAL-GA-GDPKRAKEVARVALKLSLLLGLVLAIILILF 316
|
330
....*....|....*.
gi 240254500 440 PWLFPGIFTRDKVVTS 455
Cdd:TIGR00797 317 REFIARLFTNDPEVLE 332
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
131-538 |
6.56e-22 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 98.16 E-value: 6.56e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 131 LCGPLMSLIDTAVIGQGSSLELAALGPATVICDYLCYTFMFLSVATSNLVATSLARQDKDEVQHQISILLFIGLACGVTM 210
Cdd:cd12082 9 LLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVLAILLGLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 211 MVLTRLFGSWALTAFTGvkNADIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALAVASAINGVGDVVLCT 290
Cdd:cd12082 89 AALLLFFSPLILSLLGA--EEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILLDPLLIF 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 291 FLG---YGIAGAAWATMVSQVVAA---YMMMDALNKKGYSAFSFCVPSPSELLTIFGLAAPVFITMMSKVLFYTLLVYFA 364
Cdd:cd12082 167 GLGppeLGIAGAALATVISYVIGAlllLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGLLIIVAIV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 365 TS-MGTNIIAAHQVMLQIYTMSTVWGEPLSQTAQSFMPELLfgINRNLPKARVLLKSLVIIGATLGIVVGTIGtavpWLF 443
Cdd:cd12082 247 AAfGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNL--GAGNFDRARRITWVALLIGLLIGAVLGLLI----LLF 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 444 PG----IFTRDKVVTSEMHKVIIPYFLALSITPSTHSLEGTLLAGRDLRYISLSMTGCLAVAGL-LLMLLSNGGFGLRGC 518
Cdd:cd12082 321 PEpilsLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLpLAYVLAYLGLGLYGI 400
|
410 420
....*....|....*....|
gi 240254500 519 WYALVGFQWARFSLSLFRLL 538
Cdd:cd12082 401 WLALVISLILAALVLLLFFR 420
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
135-540 |
7.00e-22 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 98.34 E-value: 7.00e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 135 LMSLIDTAVIGQGSSLELAALGPATVICDYLCYTFMFLSVATSNLVATSLARQDKDEVQHQISILLFIGLACGVTMMVLT 214
Cdd:cd13134 21 LLGTIDTFMLSRYSDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQIAGVALLFNLLLGLVFSLLL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 215 RLFGSWALTAFTgvKNADIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALAVASAINGVGDVVLCT---- 290
Cdd:cd13134 101 LFFGAELLRLMG--LPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNILNIVGNYLLIFgwfg 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 291 FLGYGIAGAAWATMVSQVVAAYMMMDAL--NKKGYSAFSFCVPSPSELL-TIFGLAAPVFITMMSKVLFYTLLVYFATSM 367
Cdd:cd13134 179 LPKLGVAGVAISTVISRAVGLVLLFILLfrKLKIRFRLKDLRPFPKKLLkKILKIGLPSAGEELSYNLSQTVITAFIARL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 368 GTNIIAAHQVMLQIYTMSTVWGEPLSQTAQSFMPELLfGiNRNLPKARVLLKSLVIIGATLGIVVGTIgtavPWLF---- 443
Cdd:cd13134 259 GTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLV-G-AGDFDEAYKRVLKSLKIGLLVSLAVALL----LALFrepi 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 444 PGIFTRDKVVTSEMHKVIIPYFLALSITPSTHSLEGTLLAGRDLRYISLSMTGCLAVAGLLLMLLS--NGGFGLRGCWYA 521
Cdd:cd13134 333 LGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGISVPLAYLLgiVLGLGLLGVWIA 412
|
410
....*....|....*....
gi 240254500 522 LVGFQWARFSLSLFRLLSR 540
Cdd:cd13134 413 FAADEWVRGIIMLWRWRSG 431
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
117-541 |
2.83e-20 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 93.36 E-value: 2.83e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 117 KEIVMFTGPAAGLWLCGPLMSLIDTAVIGQGSSLELAALGPATVICdYLCYTFMF-LSVATSNLVATSLARQDKDEVQHQ 195
Cdd:cd13133 5 REILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPAGVLY-FAILMLFFgLSSGVQVFVAQYNGAGRYSRIGRV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 196 ISILLFIGLACGVTMMVLTRLFGSWALTAFTGvkNADIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALA 275
Cdd:cd13133 84 LWQGLYFSLLLAPLLALLSALAAPLLFLLLGH--SPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 276 VASAINGVGDVVLC----TFLGYGIAGAAWATMVSQVVAA----YMMMDALNKKGYSAFSFCVPSPSELLTIFGLAAPVF 347
Cdd:cd13133 162 VMVVVNIVLDYALIfgklGFPAMGIAGAAIATVIAEAVSLlfflLLLFRRKNRRRFGLRRAWRFDRELLRRILRLGLPSG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 348 ITMMSKVLFYTLLVYFATSMGTNIIAAHQVMLQIYTMSTVWGEPLSQTAQSFMPELLfGINRnLPKARVLLKSLVIIGAT 427
Cdd:cd13133 242 LQFFLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQAL-GAGR-PDLAMRVTRRGLKLALA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 428 LGIVVGTIGTAVPWLFPGIFTRDKVVTSEMHKVIIP-YFLALSITPS--THSLEGTLLAGRDLRYISLSMTGCLAVAGLL 504
Cdd:cd13133 320 YMLLLGILFLLFPELLLSIFTPGADFALIAELAVPLlRFVAAYILFDalALVFAGALRGAGDTRFVMLAELIVAWLYLLP 399
|
410 420 430
....*....|....*....|....*....|....*...
gi 240254500 505 LMLLSNG-GFGLRGCWYALVGFQWARFSLSLFRLLSRD 541
Cdd:cd13133 400 PAYLLVVlGAGLAGAWTVETVYVIVLALIFLLRFRSGK 437
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
137-522 |
3.42e-16 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 81.02 E-value: 3.42e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 137 SLIDTAVIGQG-SSLELAALG---PATVICDYLcytFMFLSVATSNLVATSLARQDKDEVQHQISILLFIGLACGVTMMV 212
Cdd:cd13143 24 NIVDGIFVGHGvGALALAAVNlvfPIIMLLMAL---GLMIGVGGASLISRRLGAGDREKANRIFSTALLLSLILGLLLTI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 213 LTRLFGSWALTAFTGvkNADIVPAANKYVQIRGLAWPAVLIGWVAQ-------SASLGMKdswgplkALAVASAINGVGD 285
Cdd:cd13143 101 LGLLFLDPLLRLLGA--SGELLPYAVDYLRIILLGAPFTILSSVLNnllraegKPKLAML-------GMLIGAVLNIILD 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 286 VVLCTFLGYGIAGAAWATMVSQVVAAYMMMDALNKKG---YSAFSFCVPSPSELLTIFGLAAPVFITMMSKVLFYTLLVY 362
Cdd:cd13143 172 PLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKsllKLSLLRFKLSLKIIKEILALGFPSFLMQLSSSVVTIVLNL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 363 FATSMGTNI-IAAHQVMLQIYTMSTVWGEPLSQTAQSfmpelLFGIN---RNLPKARVLLKSLVIIGATLGIVVGTIGTA 438
Cdd:cd13143 252 TLLGYGGDIgVAAFGIVTRILTFLFLPLIGLSQGLQP-----IIGYNygaGNYDRVKQALKLALIVALIYGLVLFLILLL 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 439 VPWLFPGIFTRDKVVTSEMHKVIIPYFLALSITPSTHSLEGTLLAGRDLRY---ISLSMTGCLAVAGLLLMllsNGGFGL 515
Cdd:cd13143 327 FPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRaalLSLLRQGLFLIPLLLIL---PRLFGL 403
|
....*..
gi 240254500 516 RGCWYAL 522
Cdd:cd13143 404 DGIWLAF 410
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
137-451 |
4.41e-16 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 80.65 E-value: 4.41e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 137 SLIDTAVIGQGSSLELAALGPATVICdYLCYTFMFLSVA-TSNLVATSLARQDKDEVQHQISILLFIGLACGVTMMVLTR 215
Cdd:cd13140 25 NLTDMFWVGRLGSDAVAAVGTAGFFV-WLAYALALLSKIgAQVKVSQSIGAKDEKEARKYARNALQLNLLLGILYGLLLL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 216 LFGSwALTAFTGVKNADIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALAVASAINGVGDVVLC----TF 291
Cdd:cd13140 104 LFAK-PLIGFFNLGDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPFIINAIGLVLNIILDPLLIfgfgPF 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 292 LGYGIAGAAWATMVSQVVAAYMMMDALNKKGYSAFSFCV---PSPSELLTIFGLAAPVFITMMSKVLFYTLLVYFATSMG 368
Cdd:cd13140 183 PALGVAGAALATVLAQAIVFLLFLYALKKKKGLFLKIRIlkrPDRKYIKEILKLGLPVALQSILFALISMILARIIASFG 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 369 TNIIAAHQVMLQIYTMSTVWGEPLSQTAQSFmpellFGIN---RNLPKARVLLKSLVIIGATLGIVVGTIGTAVPWLFPG 445
Cdd:cd13140 263 PVAIAAQKVGSQIESISWMTAEGFSTALAAF-----VGQNygaGKYDRIRKGYKTALKIASAIGLFATLLLFFFGEPLFS 337
|
....*.
gi 240254500 446 IFTRDK 451
Cdd:cd13140 338 LFIPDP 343
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
135-523 |
6.04e-16 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 80.24 E-value: 6.04e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 135 LMSLIDTAVIGQGSSLELAALGPATVICDYLCYTFMFLSVATSNLVATSLARQDKDEVQHQISILLFIGLACGVTMMVLT 214
Cdd:cd13131 21 AMGFVDTVMAGRLGADDLAAVALGSSLWFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIRRAVRQGLWLALLLSLPLMLLL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 215 rLFGSWALTAFtGVkNADIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALAVASAINGVGDVVLC----T 290
Cdd:cd13131 101 -WLAPPILPLM-GQ-EPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLLALVLNIPLNYVLIfgkfG 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 291 FLGYGIAGAAWATMVSQVVAAYMMMDALNK----KGYSAFS-FCVPSPSELLTIFGLAAPVFITMMSKVLFYTLLVYFAT 365
Cdd:cd13131 178 LPALGGAGAGLATAIVYWLMFLALAFYIRRhkrfRRYRLFArFWRPDWARLKELLRLGLPIGLTIFFEVSLFAAVALLMG 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 366 SMGTNIIAAHQVMLQIytmstvwgeplsqTAQSFMPELLFGI-----------NRNLPKARVllksLVIIGATLGIVVGT 434
Cdd:cd13131 258 RLGTTVLAAHQIALNF-------------ASLLFMVPLGISMaatvrvgfalgAGDPADARR----AGLVGLGLGVGFAA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 435 IGTAVPWLFP----GIFTRDKVV---TSEMHKVIIPYFLALSI-TPSTHSLEGTllagRDLRYISLSMTGCLAVAGLLLM 506
Cdd:cd13131 321 LTALLLLLFPeqiaGLYTNDPAVialAASLLVFAALFQLFDGIqVVAAGALRGY----KDTRVPFLLALISYWGIGLPLG 396
|
410
....*....|....*....
gi 240254500 507 LL--SNGGFGLRGCWYALV 523
Cdd:cd13131 397 YLlaFTTGLGAFGVWIGLI 415
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
129-470 |
2.83e-14 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 74.92 E-value: 2.83e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 129 LWLCGPLMS---------LIDTAVIGQGSSLELAALGPATVICdYLCYTFMF-LSVATSNLVATSLARQDKDEVQHQISI 198
Cdd:cd13142 14 LKLAWPIIVsnllqvaynLADTFWLGRLGADAVAAPSISWPLI-FLFISLGGgLTVAGTALVAQYTGAGDYDKANKVAGQ 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 199 LLFIGLACGVTMMVLTRLFGSWALTAFTGVKnADIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALAVAS 278
Cdd:cd13142 93 TFSFVIILSLILAVLGYILSRPLLLLLIGAP-EEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGDTKTPMKIMFGSV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 279 AINGVGDVVL----CTFLGYGIAGAAWATMVSQVVAAYMMMDALNKKGYS---AFSFCVPSPSELLTIFGLAAPVFITMM 351
Cdd:cd13142 172 LLNVILDPLLifgiGPFPGLGVAGAALATVISRGIAAVIGLYLLFKGRVGlkiSLRDLKPDWEWLKKIFRIGLPSSIEQS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 352 SKVLFYTLLVYFATSMGTNIIAAHQVMLQIYTMSTVWGEPLSQtAQSFMpellFGIN---RNLPKA-RVLLKSLVIIGAT 427
Cdd:cd13142 252 ARALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLAR-ATSTM----VGQNlgaGQIDRAeEIVKKAALLIFLI 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 240254500 428 LGIvVGTIGTAVPWLFPGIFTRDKVV---TSEMHKVIIPYFLALSI 470
Cdd:cd13142 327 LVI-GGVLAFLFAEPIVRVFINDPEVikeGADFLRIVAPSFPFFGL 371
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
105-321 |
4.69e-11 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 64.80 E-value: 4.69e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 105 DDLATQSIWGQMKEIVMFTGPAAGLWLCGPLMSLIDTAVIGQGssLELAALGPATVICDYLCYTFMF-------LSVATS 177
Cdd:cd13124 212 SPRSKISTKEILKELLSYAIPITLSSLILPLLQLIDSFTVPRR--LQAAGLSESEATALYGILTGRAqplvqlpTVIATA 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 178 nlVATSL--------ARQDKDEVQHQIS----ILLFIGLACGVTMMVLTR-----LFGSwaltaftgvknadivPAANKY 240
Cdd:cd13124 290 --LSTSLvpaiseayAKGDKKELRRRINqalrLTLLIGLPAAVGLAVLAEpintlLFGD---------------SEGGLI 352
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 241 VQIrgLAWPAVLIGWVAQSASL--GMKDSWGPLKALAVASAINGVGDVVLCTFLGygIAGAAWATMVSQVVAAYMMMDAL 318
Cdd:cd13124 353 LQI--LAPSILFLSLQQVTAAIlqGLGKVKIPVINLLIGLLVKIVLNYVLIPIFG--IYGAAIATVIGFLVAALLNLRAL 428
|
...
gi 240254500 319 NKK 321
Cdd:cd13124 429 KKL 431
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
115-470 |
4.50e-10 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 61.82 E-value: 4.50e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 115 QMKEIVMFTGPAAGLWLCGPLMSLIDTAVIGQGSSLELAALGPATVICDYLCYTFMF-LSVATSNLVATSLARQDKDEV- 192
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLgLASALDTLCGQAFGAKNYKLVg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 193 ---QHQISILLFIGLACGVTMM-------------VLTRLFGSWALTAFTGVKNADIVPAANKYVQIRGLAWPAVLIGwv 256
Cdd:cd13132 81 vylQRALVILLLCCVPISLLWLntepillllgqdpEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYIS-- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 257 aqsaslgmkdswgplkalAVASAINGVGDVVLCTFLGYGIAGAAWATMVSQ-----VVAAYMMMDALNKKGYSAFSfcVP 331
Cdd:cd13132 159 ------------------LVALLLNILLNYLLVFVLGLGFIGAALATSISYwlivvLLLLYIFFSKGHKATWGGFS--RE 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 332 SPSELLTIFGLAAPVFITMMSKVLFYTLLVYFATSM-GTNIIAAHQVMLQIYTMSTVWGEPLSQTAQSFMPELLfGINRn 410
Cdd:cd13132 219 AFRGWGPFLKLAIPSALMLCLEWWAFEILVLLAGLLpGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNEL-GAGN- 296
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 240254500 411 lPK-ARVLLKSLVIIGATLGIVVGTIGTAVPWLFPGIFTRDKVVTSEMHKVIipYFLALSI 470
Cdd:cd13132 297 -PKrAKLAAIVALILSLVIGVVVAILLLVLRDVWAYLFTSDEEVIALVADLL--PILALFQ 354
|
|
| SpoVB |
COG5841 |
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ... |
108-374 |
2.30e-09 |
|
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444543 [Multi-domain] Cd Length: 532 Bit Score: 59.79 E-value: 2.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 108 ATQSIWGQMKEIVMFTGPAAGLWLCGPLMSLIDTAVIGQgsSLELAALGPATVICDYLCYTFMFL-------SVATSnlV 180
Cdd:COG5841 224 SKESSKDILKELLRIAIPITLSSLVLPLFQLIDSFTVPR--RLQAAGLSASEATSLYGILSGMAQplvnlptVLATA--L 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 181 ATSL--------ARQDKDEVQHQIS----ILLFIGLACGVTMMVLTR-----LFGSwaltaftgvknadivPAANKYVQI 243
Cdd:COG5841 300 ATSLvpaiseafAKKDRKLVRRRINqalrLTLLIGLPAAVGLAVLAEpintlLFGN---------------PEGGGILAI 364
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 244 rgLAWPAVLIGWVAQSASL--GMKDSWGPLKALAVASAINGVGDVVLCTFLGygIAGAAWATMVSQVVAAYMMMDALNKk 321
Cdd:COG5841 365 --LAPSAIFLSLQQVTTGIlqGLGKQKIPVINLLIGLLVKIILNYLLVPLFG--IYGAALATVIGYLVAAILNLAALKK- 439
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 240254500 322 gYSAFSFcvPSPSELLTIFGLAAPVFITMMskVLFYTLLVYFATSMGTNIIAA 374
Cdd:COG5841 440 -YTGFKL--DLRRRLLKPLLASLIMGIVVL--LLYRLLSLFLPESRLGALLAT 487
|
|
| PRK10367 |
PRK10367 |
DNA-damage-inducible SOS response protein; Provisional |
134-309 |
2.64e-09 |
|
DNA-damage-inducible SOS response protein; Provisional
Pssm-ID: 182413 [Multi-domain] Cd Length: 441 Bit Score: 59.37 E-value: 2.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 134 PLMSLIDTAVIGQ-GSSLELAALGPATVICDYLCYTFMFLSVATSNLVATSLARQDKDEVQHQISILLFIGLACGVTMMV 212
Cdd:PRK10367 26 PLLGLVDTAVIGHlDSPVYLGGVAVGATATSFLFMLLLFLRMSTTGLTAQAFGAKNPQALARALVQPLLLALGAGALIAL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 213 LTRLFGSWALTAFTGvkNADIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALAVASAINGVGDVVLCTFL 292
Cdd:PRK10367 106 LRTPLIDLALHIVGG--SEAVLEQARRFLEIRWLSAPASLANLVLLGWLLGVQYARAPVILLVVGNILNIVLDLWLVMGL 183
|
170
....*....|....*..
gi 240254500 293 GYGIAGAAWATMVSQVV 309
Cdd:PRK10367 184 HMNVQGAALATVIAEYA 200
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
135-521 |
2.00e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 56.47 E-value: 2.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 135 LMSLIDTAVIGQGSSLELAALGPATVIcDYLCYTFMF-LSVATSNLVATSLARQDKDEVQHQISILLFIGLACGVTMMVL 213
Cdd:cd13144 26 LYNIVDSIFVARLGENALTAVSLAFPI-QNLMIAVAVgTGVGVNALLSRSLGEKDQKEANKAANNGLLLALLSYLLFLLL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 214 TRLFGSWALTAFTgvKNADIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALAVASAINGVGDVVL----C 289
Cdd:cd13144 105 GLFGVKPFFRLFT--DDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQLIGAIINIILDPILifglF 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 290 TFLGYGIAGAAWATMVSQVVAAYMMMDALNKKGYSAFSFCVPSPSELLT---IFGLAAPVFITMMSKVLFYTLLVYFATS 366
Cdd:cd13144 183 GFPAMGIAGAAIATVIGQILAMFLAFFFLLRKNKDVQPDLRLFRPSLRIikeIYAVGLPSIIMQAISSVMVFGLNKILAG 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 367 MGTNIIAAHQVMLQIYTMstvwgeplsqtaqSFMPelLFGIN-------------RNLPKARVLLKslviIGATLGIVVG 433
Cdd:cd13144 263 FGPTAVAVFGIYFKLQSF-------------VFMP--VFGLNnglipivaynygaGNKDRIREAIK----YAILIAVVIM 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 434 TIGTAVPWLFP----GIFTrdkvVTSEMHKVIIPYFLALSI----TPSTHSLEGTLLA-GRDLRYISLSMTGCLAVAGLL 504
Cdd:cd13144 324 LAGGLLFQLFPdqllGLFN----ASEEMLAIGVPALRIISLsflfAALSIILSGLFQAlGRGVYSLIISVARQLVVLLPL 399
|
410
....*....|....*..
gi 240254500 505 LMLLSNgGFGLRGCWYA 521
Cdd:cd13144 400 AWLLAK-MFGLNGVWWS 415
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
125-287 |
1.01e-06 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 48.72 E-value: 1.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 125 PAAGLWLCGPLMSLIDTAVIGQGSSLELAALGPATVICDYLCYTFMFLSVATSNLVATSLARQDKDEVQHQISILLFIGL 204
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 205 ACGVTMMVLTRLFGSWALTAFTGvkNADIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALAVASAINGVG 284
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQ--DEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPL 158
|
...
gi 240254500 285 DVV 287
Cdd:pfam01554 159 NYL 161
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
113-315 |
1.39e-06 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 50.79 E-value: 1.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 113 WGQMKEIVMFTGPAAGLWLCGPLMSLIDTAVIGQ-GSSLELAALGPATVICDYLCYTFMFLSVATSNLVATSLARQDKDE 191
Cdd:cd12082 215 LELLRRLLRIGLPSAIQNSLLSLGLLIIVAIVAAfGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDR 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 192 VQHQISILLFIGLACGVTMMVLTRLFGSWALTAFTgvKNADIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPL 271
Cdd:cd12082 295 ARRITWVALLIGLLIGAVLGLLILLFPEPILSLFT--NDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSL 372
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 240254500 272 KALAVASAINGVGDVVLCTFLGYGIAGAAWATMVSQVVAAYMMM 315
Cdd:cd12082 373 IVSLLSYWVVRLPLAYVLAYLGLGLYGIWLALVISLILAALVLL 416
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
135-472 |
9.88e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 48.06 E-value: 9.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 135 LMSLIDTAVIGQGSSLELAALGPATVICDYLCYTFMFLSVATSNLVATSLARQDKDEVQHQISILLFIGLACGVTMMVLT 214
Cdd:cd13135 19 LQMLVDRAFLGRISIRYYSAVGNVTTPFNTITGFLGSISIGFTILGSQSVGAKDIKRINDYAISSIVYNSIIGVILFLLW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 215 rLFGSWALTAFTGVKNAdIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALAVASAINGVGDVVL----CT 290
Cdd:cd13135 99 -LFGARIIFVLFGVDGQ-ILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIKNLLNVILDYVLifgnFG 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 291 FLGYGIAGAAWATMVSQVVAA-YMMMDALNKK----GYSAFSFCVPSPSELLTIFGLAAPVFITMMSKVLFYTLLVYFAT 365
Cdd:cd13135 177 FPRLGIIGAAIATTIANVLNLiILVYLCRKIKkltfKLSNTKVLKANIRPYKFTIKLGLPLGGEEFLWNIGNLAVIRILN 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 366 SMGTNIIAAHQVMLQIYTMSTVWGEPLSQTAQSFMPELLFgiNRNLPKARVLLKSLVIIGATLGIVVGTIGTAVPWLFPG 445
Cdd:cd13135 257 RIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIG--KKDLKEALRIGNICLGLGLLIYIAAAIVFLAFPYKILS 334
|
330 340
....*....|....*....|....*..
gi 240254500 446 IFTRDKVVTSEMHKVIIpyFLALSITP 472
Cdd:cd13135 335 LFTNDPELINYSIPYLI--FIIIILFF 359
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
107-374 |
1.18e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 44.60 E-value: 1.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 107 LATQSIWgqmKEIVMFTGPAAGLWLCGPLMSLIDTAVIGQGSSLELAALG---PATVICDYLCYTfmfLSVATSNLVATS 183
Cdd:cd13149 2 LTEGSIP---RHLIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELAAISftfPVVLFLNSLTIG---LGIGASAVISRA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 184 LARQDKDEVQHQISILLFIGLACGVTMMVLTRLFGSWALTAFtGVKNaDIVPAANKYVQIRGLAWPAVLIGWVAQSASLG 263
Cdd:cd13149 76 IGAGDRNKAKRLATDSLILSLLLSVIVSLLGLFTIPPLFSLL-GASG-EILPLIVEYMAIWYLGLVFLVLPMVGNAIIRA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 264 MKDSWGPLKALAVASAINGVGDVVLctFLGY------GIAGAAWATMVSQVVAAYMMMDALNKKgYSAFSFCVPSPSELL 337
Cdd:cd13149 154 TGDTKRPSLVMLGAALVNVILDPIL--IFGFgpipgmGIAGAAIATVISRALGLGAALYFLHYH-HRLIDFSEPSLKALF 230
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 240254500 338 T----IFGLAAPVFITMMSKVLFYTLLVYFATSMGTNIIAA 374
Cdd:cd13149 231 RswkdILSIGIPAALSNILTPLSAAFITALVATYGPAAVAA 271
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
172-315 |
1.94e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 44.07 E-value: 1.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 172 LSVATSNLVATSLARQDKDEVQHQISILLFIGLACGVTMMVLTRLFgswALTAFTGVKNADIVPAANKYVQIRGLAWPAV 251
Cdd:cd13147 64 LGAGASSAISRRIGAKDKEGADNAAVHSILLGLIISIILTIVLLPF---LEPILVLMGAGEVLDLAVDYGRIIFLGSIFL 140
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 240254500 252 LIGWVAQSASLGMKDSWGPLKALAVASAINGVGDVVLCTFLGYGIAGAAWATMVSQVVAAYMMM 315
Cdd:cd13147 141 IFNNVAYGILRGEGDTKRAMYAMVAGSILNIILDPIFIYTLGLGIAGAAWATVISMLISSLVLL 204
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
131-315 |
2.99e-04 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 43.40 E-value: 2.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 131 LCGPLMSLIDTAVIGQGSSLELAAL-GPATVICDYLCYTFMFLSVATSNLVATSLARQDKDEVQHQISILLFIGLACGVT 209
Cdd:COG2244 187 LLGLLLTNLDRLLLGALLGPAAVGIySAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYRKALRLLLLLGLP 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 210 MMVLTRLFGSWALTAFTGVKNADIVPaankYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALAVASAINGVGDVVLc 289
Cdd:COG2244 267 LALGLALLAPPLLSLLFGPEYAEAAP----VLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAVLNLVLNLLL- 341
|
170 180
....*....|....*....|....*.
gi 240254500 290 tFLGYGIAGAAWATMVSQVVAAYMMM 315
Cdd:COG2244 342 -IPRYGLVGAAIATLLSYLVLLLLLL 366
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
106-453 |
3.67e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 42.97 E-value: 3.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 106 DLATQSIWGQMKEIVMftgPAAGLWLCGPLMSLIDTAVIGQGSSLELAALGPATVIcdylcyTFMFL------SVATSNL 179
Cdd:cd13145 1 DLTKGPIPKLIRKLAI---PASVGFFFNTMFNVVDTFFAGKISTEALAALSLSFPI------FFIIIaigvgiGTGTTAL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 180 VATSLARQDKDEVQHQISILLFIGLACGVTMMVLTrLFGSWALTAFTGVKNaDIVPAANKYVQIRGLAWPAVLIGWVAQS 259
Cdd:cd13145 72 IGNALGAGDRRKARRYAAQGLSFGIILAILLTVIG-LFAAPPLFRLLGAEG-DYLDLALEYMDVIFAGSIFFLLNFGLNG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 260 ASLGMKDSWGPLKALAVASAINgvgdVVLCTFLGY--------GIAGAAWATMVSQ-VVAAYMMMDALNKKGYSAF--SF 328
Cdd:cd13145 150 ILNAQGDTKSYRNFLIIGFFLN----IILDPLFIFggggipamGVSGIALATIISQfIGMFYLLYKVRKSGIISGCrlRD 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 329 CVPSPSELLTIFGLAAPVFITMMSKVLFYTLLVYFATSMGTNIIAAHQVML---QIYTMSTVW--GEPLSQTAQSfmpel 403
Cdd:cd13145 226 FIPRLDVYKEILKQGFPASLNMMTIGLGIFVITYFVGQFGDEAVAAYGIALrieQILLLPTIGlnTAVLSIAGQN----- 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 240254500 404 lFGINRNLPKARVLLKSLVIigatlGIVVGTIGTAVPWLFP----GIFTRDKVV 453
Cdd:cd13145 301 -FGAKKYDRVRETYKKALKY-----GFVIMVVATVFLLFFAeplmSLFTNDPAV 348
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
113-315 |
8.12e-04 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 42.14 E-value: 8.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 113 WGQMKEIVMFTGPAAGLWLCGPLMSLIDTAVIGQgsslelaALGPATV----ICDYLCYTFMFLSVATSNLVATSLAR-- 186
Cdd:cd13128 202 LKLAKELLRFSIPLALSGIFSLIYTRIDTIMLGY-------FLGDAAVgiynAAYRIAELLLFIPSAISTALFPRISEly 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 187 -QDKDEVQHQISILLFIGLACGVTMMVLTRLFGSWALTAFTGVKNADIVPAankyVQIrgLAWPAVLIGWVAQSASL--G 263
Cdd:cd13128 275 kNDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEEYLPAALV----LQI--LAWGFLFIFLNGIFGSIlqA 348
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 240254500 264 MKDSWGPLKALAVASAINGVGDVVLCTFlgYGIAGAAWATMVSQVVAAYMMM 315
Cdd:cd13128 349 IGKQKLTLKILLIGALLNVILNLLLIPK--YGIIGAAIATLISEFIIFILLL 398
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
172-307 |
3.45e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 40.08 E-value: 3.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 172 LSVATSNLVATSLARQDKDEVQHQISILLFIGLACGVTMMVLTRLFGSwALTAFTGVKNADIVPAANKYVQIRGLAWPAV 251
Cdd:cd13146 66 IQVGVSSLLARAIGAQRAKELDQAADSGLALALLAATVIVVLGYIFAE-PLLQLLGAKGLLLEYALEYFYYSLPGVPFIM 144
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254500 252 LIGwvaqsASLGMKDSWGPLKALAVASAINGVGDVVLCTFL----GYGIAGAAWATMVSQ 307
Cdd:cd13146 145 LIG-----VLMGVLQGEGRTKYMMMAMLIGTVVNIVLDPILifvfDMGVKGAALATVLAQ 199
|
|
| |
