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Conserved domains on  [gi|18404977|ref|NP_565901|]
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Protein kinase superfamily protein [Arabidopsis thaliana]

Protein Classification

AarF/ABC1/UbiB kinase family protein( domain architecture ID 1001702)

AarF/ABC1/UbiB kinase family protein belonging to the protein kinase superfamily, similar to Paramecium bursaria Chlorella virus protein A445L

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AarF super family cl33997
Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme ...
 161-357 5.74e-60

Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]; Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family is part of the Pathway/BioSystem: Ubiquinone biosynthesis


The actual alignment was detected with superfamily member COG0661:

Pssm-ID: 440425 [Multi-domain]  Cd Length: 487  Bit Score: 200.82  E-value: 5.74e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404977 161 VVAFRLLEVFSAFTIAAIRLRTSASVKGKSLEASeqiFGMVLKETMLHLGPTFIKVGQSLSTRPDIIGTEISKALSELHD 240
Cdd:COG0661  17 LLRYGLGELLDRLGLPRLRRLLTGEERREELRRR---RAERLRLALEELGPTFIKLGQLLSTRPDLLPPEYAEELAKLQD 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404977 241 RIPPFPWPEAVKILEGELGGPVESFFSQFSQETVAAASFGQVYRGRTLDGADVAVKVQRPDLRHAVLRDIYILRLGLGVL 320
Cdd:COG0661  94 RVPPFPFEEVRAVIEEELGRPLEELFAEFDPEPLAAASIGQVHRARLKDGREVAVKVQRPGIEEAIEADLRILRRLARLL 173

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 18404977 321 RKVAK--RENDIRVYADELGMGLAGELDFTLEAANASEF 357
Cdd:COG0661 174 ERLSPegRRLDPVEVVDEFARSLLEELDYRREAANAERF 212
 
Name Accession Description Interval E-value
AarF COG0661
Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme ...
 161-357 5.74e-60

Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]; Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440425 [Multi-domain]  Cd Length: 487  Bit Score: 200.82  E-value: 5.74e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404977 161 VVAFRLLEVFSAFTIAAIRLRTSASVKGKSLEASeqiFGMVLKETMLHLGPTFIKVGQSLSTRPDIIGTEISKALSELHD 240
Cdd:COG0661  17 LLRYGLGELLDRLGLPRLRRLLTGEERREELRRR---RAERLRLALEELGPTFIKLGQLLSTRPDLLPPEYAEELAKLQD 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404977 241 RIPPFPWPEAVKILEGELGGPVESFFSQFSQETVAAASFGQVYRGRTLDGADVAVKVQRPDLRHAVLRDIYILRLGLGVL 320
Cdd:COG0661  94 RVPPFPFEEVRAVIEEELGRPLEELFAEFDPEPLAAASIGQVHRARLKDGREVAVKVQRPGIEEAIEADLRILRRLARLL 173

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 18404977 321 RKVAK--RENDIRVYADELGMGLAGELDFTLEAANASEF 357
Cdd:COG0661 174 ERLSPegRRLDPVEVVDEFARSLLEELDYRREAANAERF 212
ABC1 pfam03109
ABC1 atypical kinase-like domain; This family includes ABC1 from yeast and AarF from E. coli. ...
 238-364 6.69e-50

ABC1 atypical kinase-like domain; This family includes ABC1 from yeast and AarF from E. coli. These proteins have a nuclear or mitochondrial subcellular location in eukaryotes. The exact molecular functions of these proteins is not clear, however yeast ABC1 suppresses a cytochrome b mRNA translation defect and is essential for the electron transfer in the bc 1 complex and E. coli AarF is required for ubiquinone production. It has been suggested that members of the ABC1 family are novel chaperonins. These proteins are unrelated to the ABC transporter proteins.


Pssm-ID: 427143 [Multi-domain]  Cd Length: 245  Bit Score: 167.80  E-value: 6.69e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404977   238 LHDRIPPFPWPEAVKILEGELGGPVESFFSQFSQETVAAASFGQVYRGRTLDGADVAVKVQRPDLRHAVLRDIYILRLGL 317
Cdd:pfam03109   2 LQDRAPPFPFEQAKKVIEEELGAPVEEIFAEFDEEPIAAASIAQVHRARLKDGEEVAVKVQRPGVKKRIRSDLLLLRFLA 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 18404977   318 GVLRKVAKRENDIRVYADELGMGLAGELDFTLEAANASEF-QLTHDFP 364
Cdd:pfam03109  82 KVAKRFFPGFRRLDWLVDEFRKSLPQELDFLREAANAEKFrENFADDP 129
UbiB TIGR01982
2-polyprenylphenol 6-hydroxylase; This model represents the enzyme (UbiB) which catalyzes the ...
 164-357 6.84e-48

2-polyprenylphenol 6-hydroxylase; This model represents the enzyme (UbiB) which catalyzes the first hydroxylation step in the ubiquinone biosynthetic pathway in bacteria. It is believed that the reaction is 2-polyprenylphenol -> 6-hydroxy-2-polyprenylphenol. This model finds hits primarily in the proteobacteria. The gene is also known as AarF in certain species. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273909  Cd Length: 437  Bit Score: 167.86  E-value: 6.84e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404977   164 FRLLEVFSAFT-------------IAAIRLRTSASVKGKSLEASEQIFGMVLKETMLHLGPTFIKVGQSLSTRPDIIGTE 230
Cdd:TIGR01982   2 RRLRRIIRVLIrygflalvespigPLSLRLLRRLLLPFSNRENRLMSRGERLRLALEELGPTFIKFGQTLSTRADLLPAD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404977   231 ISKALSELHDRIPPFPWPEAVKILEGELGGPVESFFSQFSQETVAAASFGQVYRGRTLDGADVAVKVQRPDLRHAVLRDI 310
Cdd:TIGR01982  82 IAEELSLLQDRVPPFDFKVARKVIEAALGGPLEELFAEFEEKPLAAASIAQVHRARLVDGKEVAVKVLRPGIEKTIAADI 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 18404977   311 YILRLG---LGVLRKVAKRENDIRVyADELGMGLAGELDFTLEAANASEF 357
Cdd:TIGR01982 162 ALLYRLariVERLSPDSRRLRPTEV-VKEFEKTLRRELDLRREAANASEL 210
ABC1_ADCK3-like cd05121
Activator of bc1 complex (ABC1) kinases (also called aarF domain containing kinase 3) and ...
 238-357 9.38e-41

Activator of bc1 complex (ABC1) kinases (also called aarF domain containing kinase 3) and similar proteins; This family is composed of the atypical yeast protein kinase Abc1p, its human homolog ADCK3 (also called CABC1), and similar proteins. Abc1p (also called Coq8p) is required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. It is necessary for the formation of a multi-subunit Q-biosynthetic complex and may also function in the regulation of Q synthesis. Human ADCK3 is able to rescue defects in Q synthesis and the phosphorylation state of Coq proteins in yeast Abc1 (or Coq8) mutants. Mutations in ADCK3 cause progressive cerebellar ataxia and atrophy due to Q10 deficiency. Eukaryotes contain at least two more ABC1/ADCK3-like proteins: in humans, these are the putative atypical protein kinases named ADCK1 and ADCK2. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Eight of these plant ABC1 kinase subfamilies (ABC1K1-8) are specific for photosynthetic organisms. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.


Pssm-ID: 270691 [Multi-domain]  Cd Length: 247  Bit Score: 143.79  E-value: 9.38e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404977 238 LHDRIPPFPWPEAVKILEGELGGPVESFFSQFSQETVAAASFGQVYRGRTLDGADVAVKVQRPDLRHAVLRDIYILRLGL 317
Cdd:cd05121   2 LQDDVPPFPFEEVRKIIEEELGRPLEEVFAEFDPEPLAAASIAQVHRARLKDGREVAVKVQRPGIEEIIEADLRILRRLA 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 18404977 318 GVLRKVAK--RENDIRVYADELGMGLAGELDFTLEAANASEF 357
Cdd:cd05121  82 RLLERLSPllRRLDLVAIVDEFARSLLEELDFRREARNAERF 123
ubiB PRK04750
putative ubiquinone biosynthesis protein UbiB; Reviewed
 202-363 1.26e-32

putative ubiquinone biosynthesis protein UbiB; Reviewed


Pssm-ID: 235310 [Multi-domain]  Cd Length: 537  Bit Score: 128.10  E-value: 1.26e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404977  202 LKETMLHLGPTFIKVGQSLSTRPDIIGTEISKALSELHDRIPPFPWPEAVKILEGELGGPVESFFSQFSQETVAAASFGQ 281
Cdd:PRK04750  55 LRLALEELGPIFVKFGQMLSTRRDLFPPDIADELALLQDRVPPFDGALARAIIEKALGGPVEEWFDDFDIKPLASASIAQ 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404977  282 VYRGRTLD-GADVAVKVQRPDLRHAVLRDIYILRLGLGVLRKV---AKRENDIRVYAdELGMGLAGELDFTLEAANASef 357
Cdd:PRK04750 135 VHFARLKDnGREVVVKVLRPDILPVIDADLALMYRLARWVERLlpdGRRLKPREVVA-EFEKTLHDELDLMREAANAS-- 211


                 ....*.
gi 18404977  358 QLTHDF 363
Cdd:PRK04750 212 QLRRNF 217
 
Name Accession Description Interval E-value
AarF COG0661
Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme ...
 161-357 5.74e-60

Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]; Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440425 [Multi-domain]  Cd Length: 487  Bit Score: 200.82  E-value: 5.74e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404977 161 VVAFRLLEVFSAFTIAAIRLRTSASVKGKSLEASeqiFGMVLKETMLHLGPTFIKVGQSLSTRPDIIGTEISKALSELHD 240
Cdd:COG0661  17 LLRYGLGELLDRLGLPRLRRLLTGEERREELRRR---RAERLRLALEELGPTFIKLGQLLSTRPDLLPPEYAEELAKLQD 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404977 241 RIPPFPWPEAVKILEGELGGPVESFFSQFSQETVAAASFGQVYRGRTLDGADVAVKVQRPDLRHAVLRDIYILRLGLGVL 320
Cdd:COG0661  94 RVPPFPFEEVRAVIEEELGRPLEELFAEFDPEPLAAASIGQVHRARLKDGREVAVKVQRPGIEEAIEADLRILRRLARLL 173

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 18404977 321 RKVAK--RENDIRVYADELGMGLAGELDFTLEAANASEF 357
Cdd:COG0661 174 ERLSPegRRLDPVEVVDEFARSLLEELDYRREAANAERF 212
ABC1 pfam03109
ABC1 atypical kinase-like domain; This family includes ABC1 from yeast and AarF from E. coli. ...
 238-364 6.69e-50

ABC1 atypical kinase-like domain; This family includes ABC1 from yeast and AarF from E. coli. These proteins have a nuclear or mitochondrial subcellular location in eukaryotes. The exact molecular functions of these proteins is not clear, however yeast ABC1 suppresses a cytochrome b mRNA translation defect and is essential for the electron transfer in the bc 1 complex and E. coli AarF is required for ubiquinone production. It has been suggested that members of the ABC1 family are novel chaperonins. These proteins are unrelated to the ABC transporter proteins.


Pssm-ID: 427143 [Multi-domain]  Cd Length: 245  Bit Score: 167.80  E-value: 6.69e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404977   238 LHDRIPPFPWPEAVKILEGELGGPVESFFSQFSQETVAAASFGQVYRGRTLDGADVAVKVQRPDLRHAVLRDIYILRLGL 317
Cdd:pfam03109   2 LQDRAPPFPFEQAKKVIEEELGAPVEEIFAEFDEEPIAAASIAQVHRARLKDGEEVAVKVQRPGVKKRIRSDLLLLRFLA 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 18404977   318 GVLRKVAKRENDIRVYADELGMGLAGELDFTLEAANASEF-QLTHDFP 364
Cdd:pfam03109  82 KVAKRFFPGFRRLDWLVDEFRKSLPQELDFLREAANAEKFrENFADDP 129
UbiB TIGR01982
2-polyprenylphenol 6-hydroxylase; This model represents the enzyme (UbiB) which catalyzes the ...
 164-357 6.84e-48

2-polyprenylphenol 6-hydroxylase; This model represents the enzyme (UbiB) which catalyzes the first hydroxylation step in the ubiquinone biosynthetic pathway in bacteria. It is believed that the reaction is 2-polyprenylphenol -> 6-hydroxy-2-polyprenylphenol. This model finds hits primarily in the proteobacteria. The gene is also known as AarF in certain species. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273909  Cd Length: 437  Bit Score: 167.86  E-value: 6.84e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404977   164 FRLLEVFSAFT-------------IAAIRLRTSASVKGKSLEASEQIFGMVLKETMLHLGPTFIKVGQSLSTRPDIIGTE 230
Cdd:TIGR01982   2 RRLRRIIRVLIrygflalvespigPLSLRLLRRLLLPFSNRENRLMSRGERLRLALEELGPTFIKFGQTLSTRADLLPAD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404977   231 ISKALSELHDRIPPFPWPEAVKILEGELGGPVESFFSQFSQETVAAASFGQVYRGRTLDGADVAVKVQRPDLRHAVLRDI 310
Cdd:TIGR01982  82 IAEELSLLQDRVPPFDFKVARKVIEAALGGPLEELFAEFEEKPLAAASIAQVHRARLVDGKEVAVKVLRPGIEKTIAADI 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 18404977   311 YILRLG---LGVLRKVAKRENDIRVyADELGMGLAGELDFTLEAANASEF 357
Cdd:TIGR01982 162 ALLYRLariVERLSPDSRRLRPTEV-VKEFEKTLRRELDLRREAANASEL 210
ABC1_ADCK3-like cd05121
Activator of bc1 complex (ABC1) kinases (also called aarF domain containing kinase 3) and ...
 238-357 9.38e-41

Activator of bc1 complex (ABC1) kinases (also called aarF domain containing kinase 3) and similar proteins; This family is composed of the atypical yeast protein kinase Abc1p, its human homolog ADCK3 (also called CABC1), and similar proteins. Abc1p (also called Coq8p) is required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. It is necessary for the formation of a multi-subunit Q-biosynthetic complex and may also function in the regulation of Q synthesis. Human ADCK3 is able to rescue defects in Q synthesis and the phosphorylation state of Coq proteins in yeast Abc1 (or Coq8) mutants. Mutations in ADCK3 cause progressive cerebellar ataxia and atrophy due to Q10 deficiency. Eukaryotes contain at least two more ABC1/ADCK3-like proteins: in humans, these are the putative atypical protein kinases named ADCK1 and ADCK2. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Eight of these plant ABC1 kinase subfamilies (ABC1K1-8) are specific for photosynthetic organisms. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.


Pssm-ID: 270691 [Multi-domain]  Cd Length: 247  Bit Score: 143.79  E-value: 9.38e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404977 238 LHDRIPPFPWPEAVKILEGELGGPVESFFSQFSQETVAAASFGQVYRGRTLDGADVAVKVQRPDLRHAVLRDIYILRLGL 317
Cdd:cd05121   2 LQDDVPPFPFEEVRKIIEEELGRPLEEVFAEFDPEPLAAASIAQVHRARLKDGREVAVKVQRPGIEEIIEADLRILRRLA 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 18404977 318 GVLRKVAK--RENDIRVYADELGMGLAGELDFTLEAANASEF 357
Cdd:cd05121  82 RLLERLSPllRRLDLVAIVDEFARSLLEELDFRREARNAERF 123
ubiB PRK04750
putative ubiquinone biosynthesis protein UbiB; Reviewed
 202-363 1.26e-32

putative ubiquinone biosynthesis protein UbiB; Reviewed


Pssm-ID: 235310 [Multi-domain]  Cd Length: 537  Bit Score: 128.10  E-value: 1.26e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404977  202 LKETMLHLGPTFIKVGQSLSTRPDIIGTEISKALSELHDRIPPFPWPEAVKILEGELGGPVESFFSQFSQETVAAASFGQ 281
Cdd:PRK04750  55 LRLALEELGPIFVKFGQMLSTRRDLFPPDIADELALLQDRVPPFDGALARAIIEKALGGPVEEWFDDFDIKPLASASIAQ 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404977  282 VYRGRTLD-GADVAVKVQRPDLRHAVLRDIYILRLGLGVLRKV---AKRENDIRVYAdELGMGLAGELDFTLEAANASef 357
Cdd:PRK04750 135 VHFARLKDnGREVVVKVLRPDILPVIDADLALMYRLARWVERLlpdGRRLKPREVVA-EFEKTLHDELDLMREAANAS-- 211


                 ....*.
gi 18404977  358 QLTHDF 363
Cdd:PRK04750 212 QLRRNF 217
UbiB cd13972
Ubiquinone biosynthetic protein UbiB; UbiB is the prokaryotic homolog of yeast Abc1p and human ...
 238-357 1.30e-30

Ubiquinone biosynthetic protein UbiB; UbiB is the prokaryotic homolog of yeast Abc1p and human ADCK3 (aarF domain containing kinase 3). It is required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. It is required in the first monooxygenase step in Q biosynthesis. Mutant strains with disrupted ubiB genes lack Q and accumulate octaprenylphenol, a Q biosynthetic intermediate.


Pssm-ID: 270874 [Multi-domain]  Cd Length: 247  Bit Score: 116.92  E-value: 1.30e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404977 238 LHDRIPPFPWPEAVKILEGELGGPVESFFSQFSQETVAAASFGQVYRGRTLDGADVAVKVQRPDLRHAVLRDIYILRLGL 317
Cdd:cd13972   2 LQDRVPPFSGKEARAIIEAELGKPLDALFSDFDEEPVAAASIAQVHKARLLDGREVAVKVLRPGIEKRIERDLELLRFLA 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 18404977 318 GVLRKV---AKRENDIRVyADELGMGLAGELDFTLEAANASEF 357
Cdd:cd13972  82 RLAERLlpeARRLRPVEV-VKEFARSLLLELDLRLEAANASEL 123
ABC1_ADCK3 cd13970
Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3; This ...
 233-357 3.52e-29

Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3; This subfamily is composed of the atypical yeast protein kinase Abc1p, its human homolog ADCK3 (also called CABC1), and similar proteins. Abc1p (also called Coq8p) is required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. It is necessary for the formation of a multi-subunit Q-biosynthetic complex and may also function in the regulation of Q synthesis. Human ADCK3 is able to rescue defects in Q synthesis and the phosphorylation state of Coq proteins in yeast Abc1 (or Coq8) mutants. Mutations in ADCK3 cause progressive cerebellar ataxia and atrophy due to Q10 deficiency. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Subfamily 13 (ABC1K13) of plant ABC1 kinases belongs in this subfamily with yeast Abc1p and human ADCK3. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.


Pssm-ID: 270872 [Multi-domain]  Cd Length: 251  Bit Score: 113.38  E-value: 3.52e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404977 233 KALSELHDRIPPFPWPEAVKILEGELGGPVESFFSQFSQETVAAASFGQVYRGRTLDGADVAVKVQRPDLRHAVLRDIYI 312
Cdd:cd13970   1 EALARLRDSAPPMPWAQLEKVLEAELGEDWRELFAEFDEEPFAAASIGQVHRATLKDGREVAVKVQYPGVAESIDSDLNN 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 18404977 313 LRLGLGVLRKVAKrENDIRVYADELGMGLAGELDFTLEAANASEF 357
Cdd:cd13970  81 LRRLLKLTGLLPK-GLDLDALIAELREELLEECDYEREAANQRRF 124
ADCK1-like cd13969
aarF domain containing kinase 1 and similar proteins; This subfamily is composed of ...
 237-354 9.64e-27

aarF domain containing kinase 1 and similar proteins; This subfamily is composed of uncharacterized ABC1 kinase-like proteins including the human protein called aarF domain containing kinase 1 (ADCK1). Eukaryotes contain at least three ABC1-like proteins: in humans, these are ADCK3 and the putative protein kinases named ADCK1 and ADCK2. Yeast Abc1p and its human homolog ADCK3 are atypical protein kinases required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Plant subfamilies 14 and 15 (ABC1K14-15) belong to the same group of ABC1 kinases as human ADCK1. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.


Pssm-ID: 270871 [Multi-domain]  Cd Length: 253  Bit Score: 106.80  E-value: 9.64e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404977 237 ELHDRIPPFPWPEAVKILEGELGGPVESFFSQFSQETVAAASFGQVYRGRTLDGADVAVKVQRPDLRHAVLRDIYILRLG 316
Cdd:cd13969   1 VLQDKAPQSPYEEVRRVFKEDLGKPPEELFSEFDEEPIASASLAQVHKAKLKDGEEVAVKVQHPDLRKQFAGDLATMEFL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 18404977 317 LGVLRKVAKrenDIRVY--ADELGMGLAGELDFTLEAANA 354
Cdd:cd13969  81 VNLVEKLFP---DFPFSwlVDELKKNLPKELDFLNEARNA 117
STKc_CK1 cd14016
Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1; STKs catalyze the ...
 278-341 7.69e-04

Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CK1 phosphorylates a variety of substrates including enzymes, transcription and splice factors, cytoskeletal proteins, viral oncogenes, receptors, and membrane-associated proteins. There are mutliple isoforms of CK1 and in mammals, seven isoforms (alpha, beta, gamma1-3, delta, and epsilon) have been characterized. These isoforms differ mainly in the length and structure of their C-terminal non-catalytic region. Some isoforms have several splice variants such as the long (L) and short (S) variants of CK1alpha. CK1 proteins are involved in the regulation of many cellular processes including membrane transport processes, circadian rhythm, cell division, apoptosis, and the development of cancer and neurodegenerative diseases. The CK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270918 [Multi-domain]  Cd Length: 266  Bit Score: 40.90  E-value: 7.69e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18404977 278 SFGQVYRGR-TLDGADVAVKVQRPDLRHAVLR---DIY-ILRLGLGVLR-KVAKRENDIRVYA-DELGMGL 341
Cdd:cd14016  12 SFGEVYLGIdLKTGEEVAIKIEKKDSKHPQLEyeaKVYkLLQGGPGIPRlYWFGQEGDYNVMVmDLLGPSL 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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