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Conserved domains on  [gi|18396805|ref|NP_566223|]
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Disease resistance protein (TIR-NBS class) [Arabidopsis thaliana]

Protein Classification

disease resistance family protein( domain architecture ID 1000118)

disease resistance family protein similar to Nicotiana glutinosa TMV resistance protein N; resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via a direct or indirect interaction with this avirulence protein

Gene Ontology:  GO:0006952

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN03210 super family cl33662
Resistant to P. syringae 6; Provisional
 66-489 1.40e-152

Resistant to P. syringae 6; Provisional


The actual alignment was detected with superfamily member PLN03210:

Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 465.89  E-value: 1.40e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805    66 HQVFPSFHGADVRKSFLSHIMKEFKSKGIDIFIDKDIKRGKSIGPELTEAIRGSRVAIVFLSRKYASSSWCLNELALIMK 145
Cdd:PLN03210   13 YDVFPSFSGEDVRITFLSHFLKELDRKLIIAFKDNEIERSQSLDPELKQAIRDSRIAVVVFSKNYASSSWCLNELLEIVR 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805   146 CRKELGLTVMTLFYDLDPTDVRKQTGDFGMAFKETCKGKTKDEIGRWRHALEEVAKIAGYHSSIWDNEADMIGIVTTDIS 225
Cdd:PLN03210   93 CKEELGQLVIPVFYGLDPSHVRKQTGDFGEAFEKTCQNKTEDEKIQWKQALTDVANILGYHSQNWPNEAKMIEEIANDVL 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805   226 NTLNIsTPSSDFSDLVGMEDHMKKLERMLYLDLNDVRMIGIWGPPGIGKTSIARVLFRKHSDSFDLSVFMETV------K 299
Cdd:PLN03210  173 GKLNL-TPSNDFEDFVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFIDRAfisksmE 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805   300 GYTRPGcSDEHGLKLHLQQQFLSQIFNQKDVEVPHLGVVQDRLRDKRVLVVLDDVDQSAQLEAMAKENKWFGPGSRIIIT 379
Cdd:PLN03210  252 IYSSAN-PDDYNMKLHLQRAFLSEILDKKDIKIYHLGAMEERLKHRKVLIFIDDLDDQDVLDALAGQTQWFGSGSRIIVI 330

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805   380 TQDRRLLKAHGIKDVYKVDLPPPDDAFQIFCMYAFGKTSPKHGFEELAWEATYLSGIHPSGIKSMGSYFRKMSKPEWVNA 459
Cdd:PLN03210  331 TKDKHFLRAHGIDHIYEVCLPSNELALEMFCRSAFKKNSPPDGFMELASEVALRAGNLPLGLNVLGSYLRGRDKEDWMDM 410

                         410       420       430
                  ....*....|....*....|....*....|
gi 18396805   460 LQRLRTSkLDSESPRTHRKLINRLRNVKQK 489
Cdd:PLN03210  411 LPRLRNG-LDGKIEKTLRVSYDGLNNKKDK 439
 
Name Accession Description Interval E-value
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 66-489 1.40e-152

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 465.89  E-value: 1.40e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805    66 HQVFPSFHGADVRKSFLSHIMKEFKSKGIDIFIDKDIKRGKSIGPELTEAIRGSRVAIVFLSRKYASSSWCLNELALIMK 145
Cdd:PLN03210   13 YDVFPSFSGEDVRITFLSHFLKELDRKLIIAFKDNEIERSQSLDPELKQAIRDSRIAVVVFSKNYASSSWCLNELLEIVR 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805   146 CRKELGLTVMTLFYDLDPTDVRKQTGDFGMAFKETCKGKTKDEIGRWRHALEEVAKIAGYHSSIWDNEADMIGIVTTDIS 225
Cdd:PLN03210   93 CKEELGQLVIPVFYGLDPSHVRKQTGDFGEAFEKTCQNKTEDEKIQWKQALTDVANILGYHSQNWPNEAKMIEEIANDVL 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805   226 NTLNIsTPSSDFSDLVGMEDHMKKLERMLYLDLNDVRMIGIWGPPGIGKTSIARVLFRKHSDSFDLSVFMETV------K 299
Cdd:PLN03210  173 GKLNL-TPSNDFEDFVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFIDRAfisksmE 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805   300 GYTRPGcSDEHGLKLHLQQQFLSQIFNQKDVEVPHLGVVQDRLRDKRVLVVLDDVDQSAQLEAMAKENKWFGPGSRIIIT 379
Cdd:PLN03210  252 IYSSAN-PDDYNMKLHLQRAFLSEILDKKDIKIYHLGAMEERLKHRKVLIFIDDLDDQDVLDALAGQTQWFGSGSRIIVI 330

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805   380 TQDRRLLKAHGIKDVYKVDLPPPDDAFQIFCMYAFGKTSPKHGFEELAWEATYLSGIHPSGIKSMGSYFRKMSKPEWVNA 459
Cdd:PLN03210  331 TKDKHFLRAHGIDHIYEVCLPSNELALEMFCRSAFKKNSPPDGFMELASEVALRAGNLPLGLNVLGSYLRGRDKEDWMDM 410

                         410       420       430
                  ....*....|....*....|....*....|
gi 18396805   460 LQRLRTSkLDSESPRTHRKLINRLRNVKQK 489
Cdd:PLN03210  411 LPRLRNG-LDGKIEKTLRVSYDGLNNKKDK 439
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 66-231 1.56e-64

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 207.22  E-value: 1.56e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805    66 HQVFPSFHGADVRKSFLSHIMKEFKSKGIDIFID-KDIKRGKSIGPELTEAIRGSRVAIVFLSRKYASSSWCLNELALIM 144
Cdd:pfam01582   1 YDVFLSFRGSDTREWFVSHLLKELKQKGIKLFIDdRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805   145 KCRKELGLTVMTLFYDLDPTDVRKQTGDFGMAFKETCKGKTKDEIGRWRHALEEVAKIagYHSSIWDNEADMIGIVTTDI 224
Cdd:pfam01582  81 ECALDLGQKVIPIFYEVDPSDVRKQTGSFGKAFKKHKKVLTEEKVLKWRGALNEVANI--WHSKSVSDESKFWKKIAYDI 158


                  ....*..
gi 18396805   225 SNTLNIS 231
Cdd:pfam01582 159 SNKLNGT 165
TIR smart00255
Toll - interleukin 1 - resistance;
65-200 1.71e-38

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 137.45  E-value: 1.71e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805     65 KHQVFPSFHGA-DVRKSFLSHIMKEFKSKGIDIFIDKDIkRGKSIGPELTEAIRGSRVAIVFLSRKYASSSWCLNELALI 143
Cdd:smart00255   1 EYDVFISYSGKeDVRNEFLSHLLEKLRGYGLCVFIDDFE-PGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVAA 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 18396805    144 MKCRKE-LGLTVMTLFYDLDPTDVRKQTGDFGMAFKETCKGKTKDEIGR-WRHALEEVA 200
Cdd:smart00255  80 LENALEeGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKNYLKWPEDEKEQfWKKALYAVP 138
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
238-356 7.85e-08

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 54.47  E-value: 7.85e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805 238 SDLVGMEDHMKKLERML--YLDLNDVRMIGIWGPPGIGKTSIARVLFRK---HSDSFDLSVfmETVkgYTRpgCSDEHGL 312
Cdd:COG1474  26 DRLPHREEEIEELASALrpALRGERPSNVLIYGPTGTGKTAVAKYVLEEleeEAEERGVDV--RVV--YVN--CRQASTR 99

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 18396805 313 KlhlqqQFLSQIFNQ--KDVEVPHLGV----VQDRL------RDKRVLVVLDDVDQ 356
Cdd:COG1474 100 Y-----RVLSRILEElgSGEDIPSTGLstdeLFDRLyealdeRDGVLVVVLDEIDY 150
TIGR02928 TIGR02928
orc1/cdc6 family replication initiation protein; Members of this protein family are found ...
 240-355 2.83e-07

orc1/cdc6 family replication initiation protein; Members of this protein family are found exclusively in the archaea. This set of DNA binding proteins shows homology to the origin recognition complex subunit 1/cell division control protein 6 family in eukaryotes. Several members may be found in genome and interact with each other. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274354 [Multi-domain]  Cd Length: 365  Bit Score: 52.64  E-value: 2.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805   240 LVGMEDHMKKLERMLYLDLNDVR--MIGIWGPPGIGKTSIARVLFRK---HSDSFDLSVfmetvkGYTRPGCSDEHGLkl 314
Cdd:TIGR02928  17 IVHRDEQIEELAKALRPILRGSRpsNVFIYGKTGTGKTAVTKYVMKEleeAAEDRDVRV------VTVYVNCQILDTL-- 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 18396805   315 hlqQQFLSQIFNQ---KDVEVPHLGVVQDRL----------RDKRVLVVLDDVD 355
Cdd:TIGR02928  89 ---YQVLVELANQlrgSGEEVPTTGLSTSEVfrrlykelneRGDSLIIVLDEID 139
 
Name Accession Description Interval E-value
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 66-489 1.40e-152

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 465.89  E-value: 1.40e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805    66 HQVFPSFHGADVRKSFLSHIMKEFKSKGIDIFIDKDIKRGKSIGPELTEAIRGSRVAIVFLSRKYASSSWCLNELALIMK 145
Cdd:PLN03210   13 YDVFPSFSGEDVRITFLSHFLKELDRKLIIAFKDNEIERSQSLDPELKQAIRDSRIAVVVFSKNYASSSWCLNELLEIVR 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805   146 CRKELGLTVMTLFYDLDPTDVRKQTGDFGMAFKETCKGKTKDEIGRWRHALEEVAKIAGYHSSIWDNEADMIGIVTTDIS 225
Cdd:PLN03210   93 CKEELGQLVIPVFYGLDPSHVRKQTGDFGEAFEKTCQNKTEDEKIQWKQALTDVANILGYHSQNWPNEAKMIEEIANDVL 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805   226 NTLNIsTPSSDFSDLVGMEDHMKKLERMLYLDLNDVRMIGIWGPPGIGKTSIARVLFRKHSDSFDLSVFMETV------K 299
Cdd:PLN03210  173 GKLNL-TPSNDFEDFVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFIDRAfisksmE 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805   300 GYTRPGcSDEHGLKLHLQQQFLSQIFNQKDVEVPHLGVVQDRLRDKRVLVVLDDVDQSAQLEAMAKENKWFGPGSRIIIT 379
Cdd:PLN03210  252 IYSSAN-PDDYNMKLHLQRAFLSEILDKKDIKIYHLGAMEERLKHRKVLIFIDDLDDQDVLDALAGQTQWFGSGSRIIVI 330

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805   380 TQDRRLLKAHGIKDVYKVDLPPPDDAFQIFCMYAFGKTSPKHGFEELAWEATYLSGIHPSGIKSMGSYFRKMSKPEWVNA 459
Cdd:PLN03210  331 TKDKHFLRAHGIDHIYEVCLPSNELALEMFCRSAFKKNSPPDGFMELASEVALRAGNLPLGLNVLGSYLRGRDKEDWMDM 410

                         410       420       430
                  ....*....|....*....|....*....|
gi 18396805   460 LQRLRTSkLDSESPRTHRKLINRLRNVKQK 489
Cdd:PLN03210  411 LPRLRNG-LDGKIEKTLRVSYDGLNNKKDK 439
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 66-231 1.56e-64

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 207.22  E-value: 1.56e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805    66 HQVFPSFHGADVRKSFLSHIMKEFKSKGIDIFID-KDIKRGKSIGPELTEAIRGSRVAIVFLSRKYASSSWCLNELALIM 144
Cdd:pfam01582   1 YDVFLSFRGSDTREWFVSHLLKELKQKGIKLFIDdRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805   145 KCRKELGLTVMTLFYDLDPTDVRKQTGDFGMAFKETCKGKTKDEIGRWRHALEEVAKIagYHSSIWDNEADMIGIVTTDI 224
Cdd:pfam01582  81 ECALDLGQKVIPIFYEVDPSDVRKQTGSFGKAFKKHKKVLTEEKVLKWRGALNEVANI--WHSKSVSDESKFWKKIAYDI 158


                  ....*..
gi 18396805   225 SNTLNIS 231
Cdd:pfam01582 159 SNKLNGT 165
TIR smart00255
Toll - interleukin 1 - resistance;
65-200 1.71e-38

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 137.45  E-value: 1.71e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805     65 KHQVFPSFHGA-DVRKSFLSHIMKEFKSKGIDIFIDKDIkRGKSIGPELTEAIRGSRVAIVFLSRKYASSSWCLNELALI 143
Cdd:smart00255   1 EYDVFISYSGKeDVRNEFLSHLLEKLRGYGLCVFIDDFE-PGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVAA 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 18396805    144 MKCRKE-LGLTVMTLFYDLDPTDVRKQTGDFGMAFKETCKGKTKDEIGR-WRHALEEVA 200
Cdd:smart00255  80 LENALEeGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKNYLKWPEDEKEQfWKKALYAVP 138
NB-ARC pfam00931
NB-ARC domain;
244-468 7.50e-17

NB-ARC domain;


Pssm-ID: 395745 [Multi-domain]  Cd Length: 245  Bit Score: 80.12  E-value: 7.50e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805   244 EDHMKKLERMLyLDLNDVRMIGIWGPPGIGKTSIARVLFRKHSD---SFDLSVFMETVKGYTRPGCSDEHGLKLHLQQQF 320
Cdd:pfam00931   2 EDMVEKVIGKL-SEKDEPGIVGIHGMGGVGKTTLAAQIFNDFDEvegHFDSVAWVVVSKTFTISTLQQTILQNLGLSEDD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805   321 LsQIFNQKDVevphLGVVQDRLRDKRVLVVLDDVDQSAQLEAMAKENKWFGPGSRIIITTQDRRLLKAHG-IKDVYKVDL 399
Cdd:pfam00931  81 W-DNKEEGEL----ARKIRRALLTKRFLLVLDDVWDEEDWDKIGIPLPDRENGCRVLLTTRSEEVAGRVGgPSDPHEVEL 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18396805   400 PPPDDAFQIFCMYAFGKTS-PKHGFEELAWEATYLSGIHPSGIKSMGSYFR-KMSKPEWVNALQRLRTSKL 468
Cdd:pfam00931 156 LEPDEAWELFENKVFPKTLgECELLEDVAKEIVEKCRGLPLALKVLGGLLScKKTVEEWKHVYDVLQSELK 226
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 68-165 4.98e-13

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 65.80  E-value: 4.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805    68 VFPSFHGADvrKSFLSHIMKEFKSKGIDIFIDK-DIKRGKSIGPELTEAIRGSRVAIVFLSRKYASSSWCLNELALIMKc 146
Cdd:pfam13676   1 VFISYAGED--RAWAEWLADALEAAGYRVWLDRwDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALA- 77

                          90
                  ....*....|....*....
gi 18396805   147 RKELGLTVMTLFYDLDPTD 165
Cdd:pfam13676  78 DPEGRKRLIPVRLECDLEL 96
PLN03194 PLN03194
putative disease resistance protein; Provisional
 62-204 1.71e-12

putative disease resistance protein; Provisional


Pssm-ID: 215626 [Multi-domain]  Cd Length: 187  Bit Score: 66.00  E-value: 1.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805   62 PGRKHQVFPSFHGADVRKSFLSHIMKEFKSKGIDIFID-KDIKRGKSIGPELTEAIRGSRVAIVFLSRKYASSSWCLNEL 140
Cdd:PLN03194  23 SAKPCDVFINHRGIDTKRTIATLLYDHLSRLNLRPFLDnKNMKPGDKLFDKINSAIRNCKVGVAVFSPRYCESYFCLHEL 102

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18396805  141 ALIMKCRKElgltVMTLFYDLDPTDVRKQTgdfgmafKETCKGktkDEIGRWRHALEEVAKIAG 204
Cdd:PLN03194 103 ALIMESKKR----VIPIFCDVKPSQLRVVD-------NGTCPD---EEIRRFNWALEEAKYTVG 152
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
238-356 7.85e-08

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 54.47  E-value: 7.85e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805 238 SDLVGMEDHMKKLERML--YLDLNDVRMIGIWGPPGIGKTSIARVLFRK---HSDSFDLSVfmETVkgYTRpgCSDEHGL 312
Cdd:COG1474  26 DRLPHREEEIEELASALrpALRGERPSNVLIYGPTGTGKTAVAKYVLEEleeEAEERGVDV--RVV--YVN--CRQASTR 99

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 18396805 313 KlhlqqQFLSQIFNQ--KDVEVPHLGV----VQDRL------RDKRVLVVLDDVDQ 356
Cdd:COG1474 100 Y-----RVLSRILEElgSGEDIPSTGLstdeLFDRLyealdeRDGVLVVVLDEIDY 150
TIGR02928 TIGR02928
orc1/cdc6 family replication initiation protein; Members of this protein family are found ...
 240-355 2.83e-07

orc1/cdc6 family replication initiation protein; Members of this protein family are found exclusively in the archaea. This set of DNA binding proteins shows homology to the origin recognition complex subunit 1/cell division control protein 6 family in eukaryotes. Several members may be found in genome and interact with each other. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274354 [Multi-domain]  Cd Length: 365  Bit Score: 52.64  E-value: 2.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805   240 LVGMEDHMKKLERMLYLDLNDVR--MIGIWGPPGIGKTSIARVLFRK---HSDSFDLSVfmetvkGYTRPGCSDEHGLkl 314
Cdd:TIGR02928  17 IVHRDEQIEELAKALRPILRGSRpsNVFIYGKTGTGKTAVTKYVMKEleeAAEDRDVRV------VTVYVNCQILDTL-- 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 18396805   315 hlqQQFLSQIFNQ---KDVEVPHLGVVQDRL----------RDKRVLVVLDDVD 355
Cdd:TIGR02928  89 ---YQVLVELANQlrgSGEEVPTTGLSTSEVfrrlykelneRGDSLIIVLDEID 139
COG4916 COG4916
Uncharacterized conserved protein [Function unknown];
66-166 9.08e-05

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443944 [Multi-domain]  Cd Length: 236  Bit Score: 43.95  E-value: 9.08e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805  66 HQVFPSFHGADvrKSFLSHIMKEFKSKGIDIFIDKDiKRGKSIGPELTEAI-----RGSRVAIVFLSRKYASSSWCLNEL 140
Cdd:COG4916   1 YDVALSFAGED--REFVERVAEALKARGIKVFYDEN-EEAELWGKDLDEYLqdiyrSESRFVVVFLSKDYVEKKWTGLER 77

                        90       100       110
                ....*....|....*....|....*....|
gi 18396805 141 ----ALIMKCRKElglTVMTLFydLDPTDV 166
Cdd:COG4916  78 raalARAMQRKKE---YILPIR--LDDTEI 102
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
241-380 3.60e-04

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 43.64  E-value: 3.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805 241 VGMEDHMKKLERMLYLDLNDVRMIgIWGPPGIGKTSIARVLFRKHSDSFDLS-----VFMEtVKGYTRPgcsdehglkLH 315
Cdd:COG5635 161 LNLLERIESLKRLELLEAKKKRLL-ILGEPGSGKTTLLRYLALELAERYLDAedpipILIE-LRDLAEE---------AS 229

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18396805 316 LQQQFLSQIFNQKDVEVPHLgvvQDRLRDKRVLVVLDDVD---QSAQLEAMAKE-----NKWfgPGSRIIITT 380
Cdd:COG5635 230 LEDLLAEALEKRGGEPEDAL---ERLLRNGRLLLLLDGLDevpDEADRDEVLNQlrrflERY--PKARVIITS 297
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
237-281 4.06e-04

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 42.18  E-value: 4.06e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 18396805 237 FSDLVGMEDHMKKLER-MLYLDLND-VRMIGIW--------GPPGIGKTSIARVL 281
Cdd:COG1223   1 LDDVVGQEEAKKKLKLiIKELRRREnLRKFGLWpprkilfyGPPGTGKTMLAEAL 55
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 263-281 4.53e-04

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 42.74  E-value: 4.53e-04
                        10
                ....*....|....*....
gi 18396805 263 MIgIWGPPGIGKTSIARVL 281
Cdd:COG2256  52 MI-LWGPPGTGKTTLARLI 69
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 263-281 1.26e-03

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 41.22  E-value: 1.26e-03
                         10
                 ....*....|....*....
gi 18396805  263 MIgIWGPPGIGKTSIARVL 281
Cdd:PRK13342  39 MI-LWGPPGTGKTTLARII 56
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 262-412 1.41e-03

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 39.60  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805   262 RMIGIWGPPGIGKTSIARVLFRK----HSDSFDLSVFmetvkgYTRPGCSDEHGLKLHLQQQFLSQifnQKDVEVPHLGV 337
Cdd:pfam05729   1 RTVILQGEAGSGKTTLLQKLALLwaqgKLPQGFDFVF------FLPCRELSRSGNARSLADLLFSQ---WPEPAAPVSEV 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805   338 VQDRL-RDKRVLVVLDDVDQ-SAQLEAMAKE-------NKWFG----PGSRIIITTQDRRLLKAHG---IKDVYKVDLPP 401
Cdd:pfam05729  72 WAVILeLPERLLLILDGLDElVSDLGQLDGPcpvltllSSLLRkkllPGASLLLTVRPDALRDLRRgleEPRYLEVRGFS 151

                         170
                  ....*....|.
gi 18396805   402 PDDAFQIFCMY 412
Cdd:pfam05729 152 ESDRKQYVRKY 162
ExeA COG3267
Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, ...
 232-360 2.81e-03

Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442498 [Multi-domain]  Cd Length: 261  Bit Score: 39.77  E-value: 2.81e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805 232 TPSSDFsdLVGMEDHMKKLERMLYLDLNDVRMIGIWGPPGIGKTSIARVLFRKHSDSFDLSVFmetvkgyTRPGCSDEHg 311
Cdd:COG3267  16 TPDPRF--LFLSPSHREALARLEYALAQGGGFVVLTGEVGTGKTTLLRRLLERLPDDVKVAYI-------PNPQLSPAE- 85

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805 312 lklhlqqqFLSQIFNQKDVEVPHLGV------VQDRLRD-----KRVLVVLDDvdqsAQL 360
Cdd:COG3267  86 --------LLRAIADELGLEPKGASKadllrqLQEFLLElaaagRRVVLIIDE----AQN 133
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 233-281 4.52e-03

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 39.22  E-value: 4.52e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 18396805 233 PSSDFSDLVGMEDHMKKLERMLYLDL---NDVRMIGI--------WGPPGIGKTSIARVL 281
Cdd:COG1222  73 PDVTFDDIGGLDEQIEEIREAVELPLknpELFRKYGIeppkgvllYGPPGTGKTLLAKAV 132
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 237-281 5.41e-03

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 39.12  E-value: 5.41e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 18396805 237 FSDLVGMEDHMKKLERM---------LYLDLNDVRMIGI--WGPPGIGKTSIARVL 281
Cdd:COG0464 156 LDDLGGLEEVKEELRELvalplkrpeLREEYGLPPPRGLllYGPPGTGKTLLARAL 211
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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