|
Name |
Accession |
Description |
Interval |
E-value |
| PLN00011 |
PLN00011 |
cysteine synthase |
2-324 |
0e+00 |
|
cysteine synthase
Pssm-ID: 177651 Cd Length: 323 Bit Score: 604.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 2 EEDRCSIKDDATQLIGNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKERIAYGMIKDAEDKGLITPGKSTLIEATSGNT 81
Cdd:PLN00011 1 MEDRCLIKNDVTELIGNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGKSTLIEATAGNT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 82 GIGLAFIGAAKGYKVVLTMPSSMSLERKIILLALGAEVHLTDPSKGVQGIIDKAEEICSKNPDSIMLEQFKNPSNPQTHY 161
Cdd:PLN00011 81 GIGLACIGAARGYKVILVMPSTMSLERRIILRALGAEVHLTDQSIGLKGMLEKAEEILSKTPGGYIPQQFENPANPEIHY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 162 RTTGPEIWRDSAGEVDILVAGVGTGGTLSGSGRFLKEKNKDFKVYGVEPTESAVISGGKPGTHLIQGIGAGLIPDNLDFN 241
Cdd:PLN00011 161 RTTGPEIWRDSAGKVDILVAGVGTGGTATGVGKFLKEKNKDIKVCVVEPVESAVLSGGQPGPHLIQGIGSGIIPFNLDLT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 242 VLDEVIQVTSVEAIETAKLLALKEGLLVGISSGAAAAAAIKVAKRPENAGKLIVVIFPSGGERYLSTSLFESVRHEAENL 321
Cdd:PLN00011 241 IVDEIIQVTGEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPENAGKLIVVIFPSGGERYLSTKLFESVRYEAENL 320
|
...
gi 18397061 322 PIQ 324
Cdd:PLN00011 321 PIE 323
|
|
| CysK |
COG0031 |
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the ... |
8-308 |
7.46e-155 |
|
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the Pathway/BioSystem: Cysteine biosynthesis
Pssm-ID: 439802 [Multi-domain] Cd Length: 301 Bit Score: 435.63 E-value: 7.46e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 8 IKDDATQLIGNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKERIAYGMIKDAEDKGLITPGkSTLIEATSGNTGIGLAF 87
Cdd:COG0031 3 IYDSILELIGNTPLVRLNRLSPGPGAEIYAKLESFNPGGSVKDRIALSMIEDAEKRGLLKPG-GTIVEATSGNTGIGLAM 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 88 IGAAKGYKVVLTMPSSMSLERKIILLALGAEVHLTDPSKGVQGIIDKAEEICSKNPDSIMLEQFKNPSNPQTHYRTTGPE 167
Cdd:COG0031 82 VAAAKGYRLILVMPETMSKERRALLRAYGAEVVLTPGAEGMKGAIDKAEELAAETPGAFWPNQFENPANPEAHYETTGPE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 168 IWRDSAGEVDILVAGVgtggtlsgsgRFLKEKNKDFKVYGVEPTESAVISGGKPGTHLIQGIGAGLIPDNLDFNVLDEVI 247
Cdd:COG0031 162 IWEQTDGKVDAFVAGVgtggtitgvgRYLKERNPDIKIVAVEPEGSPLLSGGEPGPHKIEGIGAGFVPKILDPSLIDEVI 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18397061 248 QVTSVEAIETAKLLALKEGLLVGISSGAAAAAAIKVAKRpENAGKLIVVIFPSGGERYLST 308
Cdd:COG0031 242 TVSDEEAFAMARRLAREEGILVGISSGAAVAAALRLAKR-LGPGKTIVTILPDSGERYLST 301
|
|
| cysK |
TIGR01139 |
cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine ... |
13-311 |
2.63e-154 |
|
cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine synthase B (CysM). CysM differs in having a broader specificity that also allows the use of thiosulfate to produce cysteine thiosulfonate. [Amino acid biosynthesis, Serine family]
Pssm-ID: 273465 Cd Length: 298 Bit Score: 434.10 E-value: 2.63e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 13 TQLIGNTPMVYLNNIvDGCVARIAAKLEMMEPCSSVKERIAYGMIKDAEDKGLITPGKsTLIEATSGNTGIGLAFIGAAK 92
Cdd:TIGR01139 2 SELIGNTPLVRLNRI-EGCNANVFVKLEGRNPSGSVKDRIALNMIWDAEKRGLLKPGK-TIVEPTSGNTGIALAMVAAAR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 93 GYKVVLTMPSSMSLERKIILLALGAEVHLTDPSKGVQGIIDKAEEICSKNPDS-IMLEQFKNPSNPQTHYRTTGPEIWRD 171
Cdd:TIGR01139 80 GYKLILTMPETMSIERRKLLKAYGAELVLTPGAEGMKGAIAKAEEIAASTPNSyFMLQQFENPANPEIHRKTTGPEIWRD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 172 SAGEVDILVAGVGTGGTLSGSGRFLKEKNKDFKVYGVEPTESAVISGGKPGTHLIQGIGAGLIPDNLDFNVLDEVIQVTS 251
Cdd:TIGR01139 160 TDGKLDAFVAGVGTGGTITGVGEVLKEQKPNIKIVAVEPAESPVLSGGKPGPHKIQGIGAGFIPKNLNRSVIDEVITVSD 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 252 VEAIETAKLLALKEGLLVGISSGAAAAAAIKVAKRPEnAGKLIVVIFPSGGERYLSTSLF 311
Cdd:TIGR01139 240 EEAIETARRLAAEEGILVGISSGAAVAAALKLAKRPE-PDKLIVVILPSTGERYLSTPLF 298
|
|
| CBS_like |
cd01561 |
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS ... |
17-307 |
7.99e-142 |
|
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.
Pssm-ID: 107204 [Multi-domain] Cd Length: 291 Bit Score: 402.28 E-value: 7.99e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 17 GNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKERIAYGMIKDAEDKGLITPGkSTLIEATSGNTGIGLAFIGAAKGYKV 96
Cdd:cd01561 1 GNTPLVRLNRLSPGTGAEIYAKLEFFNPGGSVKDRIALYMIEDAEKRGLLKPG-TTIIEPTSGNTGIGLAMVAAAKGYRF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 97 VLTMPSSMSLERKIILLALGAEVHLTDPSK--GVQGIIDKAEEICSKNPDSIMLEQFKNPSNPQTHYRTTGPEIWRDSAG 174
Cdd:cd01561 80 IIVMPETMSEEKRKLLRALGAEVILTPEAEadGMKGAIAKARELAAETPNAFWLNQFENPANPEAHYETTAPEIWEQLDG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 175 EVDILVAGVGTGGTLSGSGRFLKEKNKDFKVYGVEPTESAVISGGKPGTHLIQGIGAGLIPDNLDFNVLDEVIQVTSVEA 254
Cdd:cd01561 160 KVDAFVAGVGTGGTITGVARYLKEKNPNVRIVGVDPVGSVLFSGGPPGPHKIEGIGAGFIPENLDRSLIDEVVRVSDEEA 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 18397061 255 IETAKLLALKEGLLVGISSGAAAAAAIKVAKRPEnAGKLIVVIFPSGGERYLS 307
Cdd:cd01561 240 FAMARRLAREEGLLVGGSSGAAVAAALKLAKRLG-PGKTIVTILPDSGERYLS 291
|
|
| PALP |
pfam00291 |
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ... |
13-299 |
3.46e-60 |
|
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.
Pssm-ID: 459749 [Multi-domain] Cd Length: 295 Bit Score: 194.45 E-value: 3.46e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 13 TQLIGNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKERIAYGMIKDAEDKGlitpGKSTLIEATSGNTGIGLAFIGAAK 92
Cdd:pfam00291 2 SLGIGPTPLVRLPRLSKELGVDVYLKLESLNPTGSFKDRGALNLLLRLKEGE----GGKTVVEASSGNHGRALAAAAARL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 93 GYKVVLTMPSSMSLERKIILLALGAEVHLTDPSkgVQGIIDKAEEICSKNPDSIMLEQFKNPSNPQThYRTTGPEIWRDS 172
Cdd:pfam00291 78 GLKVTIVVPEDAPPGKLLLMRALGAEVVLVGGD--YDEAVAAARELAAEGPGAYYINQYDNPLNIEG-YGTIGLEILEQL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 173 AGEVDILVAGVGTGGTLSGSGRFLKEKNKDFKVYGVEPTESAVISGG---------KPGTHLIQGIGAGLIPDNLDFNVL 243
Cdd:pfam00291 155 GGDPDAVVVPVGGGGLIAGIARGLKELGPDVRVIGVEPEGAPALARSlaagrpvpvPVADTIADGLGVGDEPGALALDLL 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 244 ----DEVIQVTSVEAIETAKLLALKEGLLVGISSGAAAAAAIKVAKRPENAGKLIVVIFP 299
Cdd:pfam00291 235 deyvGEVVTVSDEEALEAMRLLARREGIVVEPSSAAALAALKLALAGELKGGDRVVVVLT 294
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN00011 |
PLN00011 |
cysteine synthase |
2-324 |
0e+00 |
|
cysteine synthase
Pssm-ID: 177651 Cd Length: 323 Bit Score: 604.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 2 EEDRCSIKDDATQLIGNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKERIAYGMIKDAEDKGLITPGKSTLIEATSGNT 81
Cdd:PLN00011 1 MEDRCLIKNDVTELIGNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGKSTLIEATAGNT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 82 GIGLAFIGAAKGYKVVLTMPSSMSLERKIILLALGAEVHLTDPSKGVQGIIDKAEEICSKNPDSIMLEQFKNPSNPQTHY 161
Cdd:PLN00011 81 GIGLACIGAARGYKVILVMPSTMSLERRIILRALGAEVHLTDQSIGLKGMLEKAEEILSKTPGGYIPQQFENPANPEIHY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 162 RTTGPEIWRDSAGEVDILVAGVGTGGTLSGSGRFLKEKNKDFKVYGVEPTESAVISGGKPGTHLIQGIGAGLIPDNLDFN 241
Cdd:PLN00011 161 RTTGPEIWRDSAGKVDILVAGVGTGGTATGVGKFLKEKNKDIKVCVVEPVESAVLSGGQPGPHLIQGIGSGIIPFNLDLT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 242 VLDEVIQVTSVEAIETAKLLALKEGLLVGISSGAAAAAAIKVAKRPENAGKLIVVIFPSGGERYLSTSLFESVRHEAENL 321
Cdd:PLN00011 241 IVDEIIQVTGEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPENAGKLIVVIFPSGGERYLSTKLFESVRYEAENL 320
|
...
gi 18397061 322 PIQ 324
Cdd:PLN00011 321 PIE 323
|
|
| PLN02565 |
PLN02565 |
cysteine synthase |
4-321 |
1.04e-176 |
|
cysteine synthase
Pssm-ID: 166206 Cd Length: 322 Bit Score: 491.75 E-value: 1.04e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 4 DRCSIKDDATQLIGNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKERIAYGMIKDAEDKGLITPGKSTLIEATSGNTGI 83
Cdd:PLN02565 1 EKSSIAKDVTELIGKTPLVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIGYSMITDAEEKGLIKPGESVLIEPTSGNTGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 84 GLAFIGAAKGYKVVLTMPSSMSLERKIILLALGAEVHLTDPSKGVQGIIDKAEEICSKNPDSIMLEQFKNPSNPQTHYRT 163
Cdd:PLN02565 81 GLAFMAAAKGYKLIITMPASMSLERRIILLAFGAELVLTDPAKGMKGAVQKAEEILAKTPNSYILQQFENPANPKIHYET 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 164 TGPEIWRDSAGEVDILVAGVGTGGTLSGSGRFLKEKNKDFKVYGVEPTESAVISGGKPGTHLIQGIGAGLIPDNLDFNVL 243
Cdd:PLN02565 161 TGPEIWKGTGGKVDAFVSGIGTGGTITGAGKYLKEQNPDIKLYGVEPVESAVLSGGKPGPHKIQGIGAGFIPGVLDVDLL 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18397061 244 DEVIQVTSVEAIETAKLLALKEGLLVGISSGAAAAAAIKVAKRPENAGKLIVVIFPSGGERYLSTSLFESVRHEAENL 321
Cdd:PLN02565 241 DEVVQVSSDEAIETAKLLALKEGLLVGISSGAAAAAAIKIAKRPENAGKLIVVIFPSFGERYLSSVLFESVKKEAENM 318
|
|
| CysK |
COG0031 |
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the ... |
8-308 |
7.46e-155 |
|
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the Pathway/BioSystem: Cysteine biosynthesis
Pssm-ID: 439802 [Multi-domain] Cd Length: 301 Bit Score: 435.63 E-value: 7.46e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 8 IKDDATQLIGNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKERIAYGMIKDAEDKGLITPGkSTLIEATSGNTGIGLAF 87
Cdd:COG0031 3 IYDSILELIGNTPLVRLNRLSPGPGAEIYAKLESFNPGGSVKDRIALSMIEDAEKRGLLKPG-GTIVEATSGNTGIGLAM 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 88 IGAAKGYKVVLTMPSSMSLERKIILLALGAEVHLTDPSKGVQGIIDKAEEICSKNPDSIMLEQFKNPSNPQTHYRTTGPE 167
Cdd:COG0031 82 VAAAKGYRLILVMPETMSKERRALLRAYGAEVVLTPGAEGMKGAIDKAEELAAETPGAFWPNQFENPANPEAHYETTGPE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 168 IWRDSAGEVDILVAGVgtggtlsgsgRFLKEKNKDFKVYGVEPTESAVISGGKPGTHLIQGIGAGLIPDNLDFNVLDEVI 247
Cdd:COG0031 162 IWEQTDGKVDAFVAGVgtggtitgvgRYLKERNPDIKIVAVEPEGSPLLSGGEPGPHKIEGIGAGFVPKILDPSLIDEVI 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18397061 248 QVTSVEAIETAKLLALKEGLLVGISSGAAAAAAIKVAKRpENAGKLIVVIFPSGGERYLST 308
Cdd:COG0031 242 TVSDEEAFAMARRLAREEGILVGISSGAAVAAALRLAKR-LGPGKTIVTILPDSGERYLST 301
|
|
| cysK |
TIGR01139 |
cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine ... |
13-311 |
2.63e-154 |
|
cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine synthase B (CysM). CysM differs in having a broader specificity that also allows the use of thiosulfate to produce cysteine thiosulfonate. [Amino acid biosynthesis, Serine family]
Pssm-ID: 273465 Cd Length: 298 Bit Score: 434.10 E-value: 2.63e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 13 TQLIGNTPMVYLNNIvDGCVARIAAKLEMMEPCSSVKERIAYGMIKDAEDKGLITPGKsTLIEATSGNTGIGLAFIGAAK 92
Cdd:TIGR01139 2 SELIGNTPLVRLNRI-EGCNANVFVKLEGRNPSGSVKDRIALNMIWDAEKRGLLKPGK-TIVEPTSGNTGIALAMVAAAR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 93 GYKVVLTMPSSMSLERKIILLALGAEVHLTDPSKGVQGIIDKAEEICSKNPDS-IMLEQFKNPSNPQTHYRTTGPEIWRD 171
Cdd:TIGR01139 80 GYKLILTMPETMSIERRKLLKAYGAELVLTPGAEGMKGAIAKAEEIAASTPNSyFMLQQFENPANPEIHRKTTGPEIWRD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 172 SAGEVDILVAGVGTGGTLSGSGRFLKEKNKDFKVYGVEPTESAVISGGKPGTHLIQGIGAGLIPDNLDFNVLDEVIQVTS 251
Cdd:TIGR01139 160 TDGKLDAFVAGVGTGGTITGVGEVLKEQKPNIKIVAVEPAESPVLSGGKPGPHKIQGIGAGFIPKNLNRSVIDEVITVSD 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 252 VEAIETAKLLALKEGLLVGISSGAAAAAAIKVAKRPEnAGKLIVVIFPSGGERYLSTSLF 311
Cdd:TIGR01139 240 EEAIETARRLAAEEGILVGISSGAAVAAALKLAKRPE-PDKLIVVILPSTGERYLSTPLF 298
|
|
| cysKM |
TIGR01136 |
cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and ... |
13-311 |
5.91e-152 |
|
cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and CysM) from cystathionine beta-synthase, a protein found primarily in eukaryotes and carrying a C-terminal CBS domain lacking from this protein. Bacterial proteins lacking the CBS domain but otherwise showing resemblamnce to cystathionine beta-synthases and considerable phylogenetic distance from known cysteine synthases were excluded from the seed and score below the trusted cutoff. [Amino acid biosynthesis, Serine family]
Pssm-ID: 273463 Cd Length: 299 Bit Score: 428.24 E-value: 5.91e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 13 TQLIGNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKERIAYGMIKDAEDKGLITPGKsTLIEATSGNTGIGLAFIGAAK 92
Cdd:TIGR01136 2 EELIGNTPLVRLNRLAPGCDARVLAKLEGFNPSGSVKDRIALSMILDAEKRGLLKPGD-TIIEATSGNTGIALAMVAAAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 93 GYKVVLTMPSSMSLERKIILLALGAEVHLTDPSKGVQGIIDKAEEICSKNPDSIMLEQFKNPSNPQTHYRTTGPEIWRDS 172
Cdd:TIGR01136 81 GYKLILTMPETMSLERRKLLRAYGAELILTPGEEGMKGAIDKAEELAAETNKYVMLDQFENPANPEAHYKTTGPEIWRDT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 173 AGEVDILVAGVGTGGTLSGSGRFLKEKNKDFKVYGVEPTESAVISGGKPGTHLIQGIGAGLIPDNLDFNVLDEVIQVTSV 252
Cdd:TIGR01136 161 DGRIDHFVAGVGTGGTITGVGRYLKEQNPNIQIVAVEPAESPVLSGGEPGPHKIQGIGAGFIPKILDLSLIDEVITVSDE 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 18397061 253 EAIETAKLLALKEGLLVGISSGAAAAAAIKVAKRPENAGKLIVVIFPSGGERYLSTSLF 311
Cdd:TIGR01136 241 DAIETARRLAREEGILVGISSGAAVAAALKLAKRLENADKVIVAILPDTGERYLSTGLF 299
|
|
| PLN03013 |
PLN03013 |
cysteine synthase |
4-321 |
5.43e-149 |
|
cysteine synthase
Pssm-ID: 178587 [Multi-domain] Cd Length: 429 Bit Score: 425.73 E-value: 5.43e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 4 DRCSIKDDATQLIGNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKERIAYGMIKDAEDKGLITPGKSTLIEATSGNTGI 83
Cdd:PLN03013 109 DGLNIADNVSQLIGKTPMVYLNSIAKGCVANIAAKLEIMEPCCSVKDRIGYSMVTDAEQKGFISPGKSVLVEPTSGNTGI 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 84 GLAFIGAAKGYKVVLTMPSSMSLERKIILLALGAEVHLTDPSKGVQGIIDKAEEICSKNPDSIMLEQFKNPSNPQTHYRT 163
Cdd:PLN03013 189 GLAFIAASRGYRLILTMPASMSMERRVLLKAFGAELVLTDPAKGMTGAVQKAEEILKNTPDAYMLQQFDNPANPKIHYET 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 164 TGPEIWRDSAGEVDILVAGVGTGGTLSGSGRFLKEKNKDFKVYGVEPTESAVISGGKPGTHLIQGIGAGLIPDNLDFNVL 243
Cdd:PLN03013 269 TGPEIWDDTKGKVDIFVAGIGTGGTITGVGRFIKEKNPKTQVIGVEPTESDILSGGKPGPHKIQGIGAGFIPKNLDQKIM 348
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18397061 244 DEVIQVTSVEAIETAKLLALKEGLLVGISSGAAAAAAIKVAKRPENAGKLIVVIFPSGGeRYLSTSLFESVRHEAENL 321
Cdd:PLN03013 349 DEVIAISSEEAIETAKQLALKEGLMVGISSGAAAAAAIKVAKRPENAGKLIAVSLFASG-RDIYTPRCSSLSGKRWRK 425
|
|
| CBS_like |
cd01561 |
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS ... |
17-307 |
7.99e-142 |
|
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.
Pssm-ID: 107204 [Multi-domain] Cd Length: 291 Bit Score: 402.28 E-value: 7.99e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 17 GNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKERIAYGMIKDAEDKGLITPGkSTLIEATSGNTGIGLAFIGAAKGYKV 96
Cdd:cd01561 1 GNTPLVRLNRLSPGTGAEIYAKLEFFNPGGSVKDRIALYMIEDAEKRGLLKPG-TTIIEPTSGNTGIGLAMVAAAKGYRF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 97 VLTMPSSMSLERKIILLALGAEVHLTDPSK--GVQGIIDKAEEICSKNPDSIMLEQFKNPSNPQTHYRTTGPEIWRDSAG 174
Cdd:cd01561 80 IIVMPETMSEEKRKLLRALGAEVILTPEAEadGMKGAIAKARELAAETPNAFWLNQFENPANPEAHYETTAPEIWEQLDG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 175 EVDILVAGVGTGGTLSGSGRFLKEKNKDFKVYGVEPTESAVISGGKPGTHLIQGIGAGLIPDNLDFNVLDEVIQVTSVEA 254
Cdd:cd01561 160 KVDAFVAGVGTGGTITGVARYLKEKNPNVRIVGVDPVGSVLFSGGPPGPHKIEGIGAGFIPENLDRSLIDEVVRVSDEEA 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 18397061 255 IETAKLLALKEGLLVGISSGAAAAAAIKVAKRPEnAGKLIVVIFPSGGERYLS 307
Cdd:cd01561 240 FAMARRLAREEGLLVGGSSGAAVAAALKLAKRLG-PGKTIVTILPDSGERYLS 291
|
|
| PLN02556 |
PLN02556 |
cysteine synthase/L-3-cyanoalanine synthase |
8-321 |
2.20e-140 |
|
cysteine synthase/L-3-cyanoalanine synthase
Pssm-ID: 178171 [Multi-domain] Cd Length: 368 Bit Score: 401.65 E-value: 2.20e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 8 IKDDATQLIGNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKERIAYGMIKDAEDKGLITPGKSTLIEATSGNTGIGLAF 87
Cdd:PLN02556 49 IKTDASQLIGKTPLVYLNKVTEGCGAYIAAKQEMFQPTSSIKDRPALAMIEDAEKKNLITPGKTTLIEPTSGNMGISLAF 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 88 IGAAKGYKVVLTMPSSMSLERKIILLALGAEVHLTDPSKGVQGIIDKAEEICSKNPDSIMLEQFKNPSNPQTHYRTTGPE 167
Cdd:PLN02556 129 MAAMKGYKMILTMPSYTSLERRVTMRAFGAELVLTDPTKGMGGTVKKAYELLESTPDAFMLQQFSNPANTQVHFETTGPE 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 168 IWRDSAGEVDILVAGVGTGGTLSGSGRFLKEKNKDFKVYGVEPTESAVISGGKPGTHLIQGIGAGLIPDNLDFNVLDEVI 247
Cdd:PLN02556 209 IWEDTLGQVDIFVMGIGSGGTVSGVGKYLKSKNPNVKIYGVEPAESNVLNGGKPGPHHITGNGVGFKPDILDMDVMEKVL 288
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18397061 248 QVTSVEAIETAKLLALKEGLLVGISSGAAAAAAIKVAKRPENAGKLIVVIFPSGGERYLSTSLFESVRHEAENL 321
Cdd:PLN02556 289 EVSSEDAVNMARELALKEGLMVGISSGANTVAALRLAKMPENKGKLIVTVHPSFGERYLSSVLFQELRKEAENM 362
|
|
| PRK10717 |
PRK10717 |
cysteine synthase A; Provisional |
7-312 |
1.46e-100 |
|
cysteine synthase A; Provisional
Pssm-ID: 182672 [Multi-domain] Cd Length: 330 Bit Score: 298.70 E-value: 1.46e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 7 SIKDDATQLIGNTPMVYLNNIVD--GCvaRIAAKLEMMEPCSSVKERIAYGMIKDAEDKGLITPGKsTLIEATSGNTGIG 84
Cdd:PRK10717 2 KIFEDVSDTIGNTPLIRLNRASEatGC--EILGKAEFLNPGGSVKDRAALNIIWDAEKRGLLKPGG-TIVEGTAGNTGIG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 85 LAFIGAAKGYKVVLTMPSSMSLERKIILLALGAEVHLT------DPSKGVQGIIDKAEEICSKNPD-SIMLEQFKNPSNP 157
Cdd:PRK10717 79 LALVAAARGYKTVIVMPETQSQEKKDLLRALGAELVLVpaapyaNPNNYVKGAGRLAEELVASEPNgAIWANQFDNPANR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 158 QTHYRTTGPEIWRDSAGEVDILVAGVGTGGTLSGSGRFLKEKNKDFKVYGVEPTESAVIS---GG---KPGTHLIQGIGA 231
Cdd:PRK10717 159 EAHYETTGPEIWEQTDGKVDGFVCAVGTGGTLAGVSRYLKETNPKVKIVLADPTGSALYSyykTGelkAEGSSITEGIGQ 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 232 GLIPDNLDFNVLDEVIQVTSVEAIETAKLLALKEGLLVGISSGAAAAAAIKVAKRpENAGKLIVVIFPSGGERYLSTSLF 311
Cdd:PRK10717 239 GRITANLEGAPIDDAIRIPDEEALSTAYRLLEEEGLCLGGSSGINVAAALRLARE-LGPGHTIVTILCDSGERYQSKLFN 317
|
.
gi 18397061 312 E 312
Cdd:PRK10717 318 P 318
|
|
| cysM |
PRK11761 |
cysteine synthase CysM; |
14-313 |
5.53e-91 |
|
cysteine synthase CysM;
Pssm-ID: 236972 Cd Length: 296 Bit Score: 273.29 E-value: 5.53e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 14 QLIGNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKERIAYGMIKDAEDKGLITPGkSTLIEATSGNTGIGLAFIGAAKG 93
Cdd:PRK11761 8 DTIGNTPLVKLQRLPPDRGNTILAKLEGNNPAGSVKDRPALSMIVQAEKRGEIKPG-DTLIEATSGNTGIALAMIAAIKG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 94 YKVVLTMPSSMSLERKIILLALGAEVHLTDPSKGVQGIIDKAEEICSKNpDSIMLEQFKNPSNPQTHYRTTGPEIWRDSA 173
Cdd:PRK11761 87 YRMKLIMPENMSQERRAAMRAYGAELILVPKEQGMEGARDLALQMQAEG-EGKVLDQFANPDNPLAHYETTGPEIWRQTE 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 174 GEVDILVAGVGTGGTLSGSGRFLKEKNKDFKVYGVEPTESAVISGgkpgthlIQGIGAGLIPDNLDFNVLDEVIQVTSVE 253
Cdd:PRK11761 166 GRITHFVSSMGTTGTIMGVSRYLKEQNPAVQIVGLQPEEGSSIPG-------IRRWPEEYLPKIFDASRVDRVLDVSQQE 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 254 AIETAKLLALKEGLLVGISSGAAAAAAIKVAKRPENAgkLIVVIFPSGGERYLSTSLFES 313
Cdd:PRK11761 239 AENTMRRLAREEGIFCGVSSGGAVAAALRIARENPNA--VIVAIICDRGDRYLSTGVFPA 296
|
|
| cysta_beta |
TIGR01137 |
cystathionine beta-synthase; Members of this family closely resemble cysteine synthase but ... |
8-307 |
6.90e-79 |
|
cystathionine beta-synthase; Members of this family closely resemble cysteine synthase but contain an additional C-terminal CBS domain. The function of any bacterial member included in this family is proposed but not proven. [Amino acid biosynthesis, Serine family]
Pssm-ID: 273464 [Multi-domain] Cd Length: 455 Bit Score: 247.41 E-value: 6.90e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 8 IKDDATQLIGNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKERIAYGMIKDAEDKGLITPGkSTLIEATSGNTGIGLAF 87
Cdd:TIGR01137 1 ILDNILDLIGNTPLVRLNKVSKGLKCELLAKCEFFNPGGSVKDRIALRMIEDAEASGRLKPG-DTIIEPTSGNTGIGLAL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 88 IGAAKGYKVVLTMPSSMSLERKIILLALGAEVHLT-------DPSKGVqGIIDKAEeicSKNPDSIMLEQFKNPSNPQTH 160
Cdd:TIGR01137 80 VAAIKGYKCIIVLPEKMSSEKVDVLRALGAEIVRTptaaafdSPESHI-GVAKRLV---REIPGAHILDQYRNPSNPLAH 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 161 YRTTGPEIWRDSAGEVDILVAGVGTGGTLSGSGRFLKEKNKDFKVYGVEPtESAVISGGKP------GTHLIQGIGAGLI 234
Cdd:TIGR01137 156 YDTTGPEILEQCEGKLDMFVAGVGTGGTITGIARYLKESCPGCRIVGADP-EGSILAQPEElnqtgrTPYKVEGIGYDFI 234
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18397061 235 PDNLDFNVLDEVIQVTSVEAIETAKLLALKEGLLVGISSGAAAAAAIKVAKRPENAGKLIVVIFPSGGERYLS 307
Cdd:TIGR01137 235 PTVLDRKVVDEWIKTDDKESFTMARRLIKEEGLLVGGSSGSAVVAALKAAEDELQEGQRCVVLLPDSIRNYMT 307
|
|
| Trp-synth-beta_II |
cd00640 |
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP) ... |
19-301 |
1.55e-60 |
|
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan synthase beta chain (Trp-synth_B), cystathionine beta-synthase (CBS), O-acetylserine sulfhydrylase (CS), serine dehydratase (Ser-dehyd), threonine dehydratase (Thr-dehyd), diaminopropionate ammonia lyase (DAL), and threonine synthase (Thr-synth). ACCD catalyzes the conversion of 1-aminocyclopropane-1-carboxylate to alpha-ketobutyrate and ammonia. Tryptophan synthase folds into a tetramer, where the beta chain is the catalytic PLP-binding subunit and catalyzes the formation of L-tryptophan from indole and L-serine. CBS is a tetrameric hemeprotein that catalyzes condensation of serine and homocysteine to cystathionine. CS is a homodimer that catalyzes the formation of L-cysteine from O-acetyl-L-serine. Ser-dehyd catalyzes the conversion of L- or D-serine to pyruvate and ammonia. Thr-dehyd is active as a homodimer and catalyzes the conversion of L-threonine to 2-oxobutanoate and ammonia. DAL is also a homodimer and catalyzes the alpha, beta-elimination reaction of both L- and D-alpha, beta-diaminopropionate to form pyruvate and ammonia. Thr-synth catalyzes the formation of threonine and inorganic phosphate from O-phosphohomoserine.
Pssm-ID: 107202 [Multi-domain] Cd Length: 244 Bit Score: 193.50 E-value: 1.55e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 19 TPMVYLNNIVDGCVARIAAKLEMMEPCSSVKERIAYGMIKDAEDKGLItpGKSTLIEATSGNTGIGLAFIGAAKGYKVVL 98
Cdd:cd00640 1 TPLVRLKRLSKLGGANIYLKLEFLNPTGSFKDRGALNLILLAEEEGKL--PKGVIIESTGGNTGIALAAAAARLGLKCTI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 99 TMPSSMSLERKIILLALGAEVHLTDPskGVQGIIDKAEEICSKNPDSIMLEQFKNPSNPQTHYrTTGPEIWRDSAGE-VD 177
Cdd:cd00640 79 VMPEGASPEKVAQMRALGAEVVLVPG--DFDDAIALAKELAEEDPGAYYVNQFDNPANIAGQG-TIGLEILEQLGGQkPD 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 178 ILVAGVGTGGTLSGSGRFLKEKNKDFKVYGVEPtesavisggkpgthliqgigaglipdnldfnvldEVIQVTSVEAIET 257
Cdd:cd00640 156 AVVVPVGGGGNIAGIARALKELLPNVKVIGVEP----------------------------------EVVTVSDEEALEA 201
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 18397061 258 AKLLALKEGLLVGISSGAAAAAAIKVAKRPeNAGKLIVVIFPSG 301
Cdd:cd00640 202 IRLLAREEGILVEPSSAAALAAALKLAKKL-GKGKTVVVILTGG 244
|
|
| PALP |
pfam00291 |
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ... |
13-299 |
3.46e-60 |
|
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.
Pssm-ID: 459749 [Multi-domain] Cd Length: 295 Bit Score: 194.45 E-value: 3.46e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 13 TQLIGNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKERIAYGMIKDAEDKGlitpGKSTLIEATSGNTGIGLAFIGAAK 92
Cdd:pfam00291 2 SLGIGPTPLVRLPRLSKELGVDVYLKLESLNPTGSFKDRGALNLLLRLKEGE----GGKTVVEASSGNHGRALAAAAARL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 93 GYKVVLTMPSSMSLERKIILLALGAEVHLTDPSkgVQGIIDKAEEICSKNPDSIMLEQFKNPSNPQThYRTTGPEIWRDS 172
Cdd:pfam00291 78 GLKVTIVVPEDAPPGKLLLMRALGAEVVLVGGD--YDEAVAAARELAAEGPGAYYINQYDNPLNIEG-YGTIGLEILEQL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 173 AGEVDILVAGVGTGGTLSGSGRFLKEKNKDFKVYGVEPTESAVISGG---------KPGTHLIQGIGAGLIPDNLDFNVL 243
Cdd:pfam00291 155 GGDPDAVVVPVGGGGLIAGIARGLKELGPDVRVIGVEPEGAPALARSlaagrpvpvPVADTIADGLGVGDEPGALALDLL 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 244 ----DEVIQVTSVEAIETAKLLALKEGLLVGISSGAAAAAAIKVAKRPENAGKLIVVIFP 299
Cdd:pfam00291 235 deyvGEVVTVSDEEALEAMRLLARREGIVVEPSSAAALAALKLALAGELKGGDRVVVVLT 294
|
|
| PLN02356 |
PLN02356 |
phosphateglycerate kinase |
16-307 |
3.35e-35 |
|
phosphateglycerate kinase
Pssm-ID: 215204 Cd Length: 423 Bit Score: 132.42 E-value: 3.35e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 16 IGNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKERIAYGMIKDAEDKGLITPGkSTLIEATSGNTGIGLAFIGAAKGYK 95
Cdd:PLN02356 51 IGNTPLIRINSLSEATGCEILGKCEFLNPGGSVKDRVAVKIIEEALESGQLFPG-GVVTEGSAGSTAISLATVAPAYGCK 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 96 VVLTMPSSMSLERKIILLALGAEVHLTDPSK---------GVQGIIDKAEEICSK-----NPDSIMLE------------ 149
Cdd:PLN02356 130 CHVVIPDDVAIEKSQILEALGATVERVRPVSithkdhyvnIARRRALEANELASKrrkgsETDGIHLEktngciseeeke 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 150 ---------------QFKNPSNPQTHYRTTGPEIWRDSAGEVDILVAGVGTGGTLSGSGRFLKEKNKDFKVYGVEPTESA 214
Cdd:PLN02356 210 nslfsssctggffadQFENLANFRAHYEGTGPEIWEQTQGNLDAFVAAAGTGGTLAGVSRFLQEKNPNIKCFLIDPPGSG 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 215 V---ISGG--------------KPGTHLIQGIGAGLIPDNLDFNVLDEVIQVTSVEAIETAKLLALKEGLLVGISSGAAA 277
Cdd:PLN02356 290 LfnkVTRGvmytreeaegrrlkNPFDTITEGIGINRLTQNFLMAKLDGAFRGTDKEAVEMSRYLLKNDGLFVGSSSAMNC 369
|
330 340 350
....*....|....*....|....*....|
gi 18397061 278 AAAIKVAKRPeNAGKLIVVIFPSGGERYLS 307
Cdd:PLN02356 370 VGAVRVAQSL-GPGHTIVTILCDSGMRHLS 398
|
|
| Thr-dehyd |
cd01562 |
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. ... |
19-302 |
1.55e-11 |
|
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly converted into NH4+. The direct deamination is catalyzed by threonine dehydratase, in which pyridoxal phosphate (PLP) is the prosthetic group. Threonine dehydratase is widely distributed in all three major phylogenetic divisions.
Pssm-ID: 107205 [Multi-domain] Cd Length: 304 Bit Score: 64.05 E-value: 1.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 19 TPMVYLNNIVDGCVARIAAKLEMMEPCSSVKERIAYGMI----KDAEDKGLITpgkstlieATSGNTGIGLAFIGAAKGY 94
Cdd:cd01562 18 TPLLTSPTLSELLGAEVYLKCENLQKTGSFKIRGAYNKLlslsEEERAKGVVA--------ASAGNHAQGVAYAAKLLGI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 95 KVVLTMPSSMSLERKIILLALGAEVHLTDPSkgVQGIIDKAEEICSKN----------PDsIMLEQfknpsnpqthyRTT 164
Cdd:cd01562 90 PATIVMPETAPAAKVDATRAYGAEVVLYGED--FDEAEAKARELAEEEgltfihpfddPD-VIAGQ-----------GTI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 165 GPEIWRDsAGEVDI---------LVAGVGTggtlsgsgrFLKEKNKDFKVYGVEPTESAVIS----GGKPGTH----LIQ 227
Cdd:cd01562 156 GLEILEQ-VPDLDAvfvpvggggLIAGIAT---------AVKALSPNTKVIGVEPEGAPAMAqslaAGKPVTLpevdTIA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 228 GIGAGLIPDNLDFNV----LDEVIQVTSVEAIETAKLLALKEGLLV------GISSGaaaaaaikVAKRPENAGKLIVVI 297
Cdd:cd01562 226 DGLAVKRPGELTFEIirklVDDVVTVSEDEIAAAMLLLFEREKLVAepagalALAAL--------LSGKLDLKGKKVVVV 297
|
....*
gi 18397061 298 FpSGG 302
Cdd:cd01562 298 L-SGG 301
|
|
| IlvA |
COG1171 |
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the ... |
19-270 |
2.65e-09 |
|
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440784 [Multi-domain] Cd Length: 327 Bit Score: 57.35 E-value: 2.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 19 TPMVYLNNIVDGCVARIAAKLEMMEPCSSVKERIAYGMI----KDAEDKGLITpgkstlieATSGNTGIGLAFIGAAKGY 94
Cdd:COG1171 25 TPLLRSPTLSERLGAEVYLKLENLQPTGSFKLRGAYNALaslsEEERARGVVA--------ASAGNHAQGVAYAARLLGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 95 KVVLTMPSSMSLERKIILLALGAEVHLTDPSkgvqgiIDKAEEIC---SKNPDSIMLEqfknPSNP------QThyrTTG 165
Cdd:COG1171 97 PATIVMPETAPAVKVAATRAYGAEVVLHGDT------YDDAEAAAaelAEEEGATFVH----PFDDpdviagQG---TIA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 166 PEIWRDsAGEVDILV---------AGVGTggtlsgsgrFLKEKNKDFKVYGVEPTESAV----ISGGKP----GTHLI-Q 227
Cdd:COG1171 164 LEILEQ-LPDLDAVFvpvggggliAGVAA---------ALKALSPDIRVIGVEPEGAAAmyrsLAAGEPvtlpGVDTIaD 233
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 18397061 228 GIGAGLiPDNLDFNVL----DEVIQVTSVEAIETAKLLALKEGLLVG 270
Cdd:COG1171 234 GLAVGR-PGELTFEILrdlvDDIVTVSEDEIAAAMRLLLERTKIVVE 279
|
|
| Thr-synth_1 |
cd01563 |
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last ... |
17-176 |
2.81e-08 |
|
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants.
Pssm-ID: 107206 [Multi-domain] Cd Length: 324 Bit Score: 54.52 E-value: 2.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 17 GNTPMVYLNNIVD-GCVARIAAKLEMMEPCSSVKERIAYGMIKDAedKGLitpGKSTLIEATSGNTGIGLAFIGAAKGYK 95
Cdd:cd01563 21 GNTPLVRAPRLGErLGGKNLYVKDEGLNPTGSFKDRGMTVAVSKA--KEL---GVKAVACASTGNTSASLAAYAARAGIK 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 96 VVLTMPSSMSLERKIILLALGAEVHltdpskGVQGIIDKA----EEICSKNPdsIMLEQFKNPsnpqthYR-----TTGP 166
Cdd:cd01563 96 CVVFLPAGKALGKLAQALAYGATVL------AVEGNFDDAlrlvRELAEENW--IYLSNSLNP------YRlegqkTIAF 161
|
170
....*....|
gi 18397061 167 EIWRDSAGEV 176
Cdd:cd01563 162 EIAEQLGWEV 171
|
|
| PRK08329 |
PRK08329 |
threonine synthase; Validated |
38-126 |
4.25e-06 |
|
threonine synthase; Validated
Pssm-ID: 236244 [Multi-domain] Cd Length: 347 Bit Score: 47.90 E-value: 4.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 38 KLEMMEPCSSVKERIAYGMIKDAEDKGLitpgKSTLIEaTSGNTGIGLAFIGAAKGYKVVLTMPSSMSLERKIILLALGA 117
Cdd:PRK08329 77 KLDYLQPTGSFKDRGTYVTVAKLKEEGI----NEVVID-SSGNAALSLALYSLSEGIKVHVFVSYNASKEKISLLSRLGA 151
|
....*....
gi 18397061 118 EVHLTDPSK 126
Cdd:PRK08329 152 ELHFVEGDR 160
|
|
| PRK06381 |
PRK06381 |
threonine synthase; Validated |
34-119 |
1.17e-05 |
|
threonine synthase; Validated
Pssm-ID: 235789 Cd Length: 319 Bit Score: 46.24 E-value: 1.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 34 RIAAKLEMMEPCSSVKERIAYGMIKDAEDKGLitpgkSTLIEATSGNTGIGLAFIGAAKGYKVVLTMPSSMSLERKIILL 113
Cdd:PRK06381 32 KIYLKFEGANPTGTQKDRIAEAHVRRAMRLGY-----SGITVGTCGNYGASIAYFARLYGLKAVIFIPRSYSNSRVKEME 106
|
....*.
gi 18397061 114 ALGAEV 119
Cdd:PRK06381 107 KYGAEI 112
|
|
| ThrC |
COG0498 |
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the ... |
17-141 |
1.62e-04 |
|
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the Pathway/BioSystem: Threonine biosynthesis
Pssm-ID: 440264 [Multi-domain] Cd Length: 394 Bit Score: 42.88 E-value: 1.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 17 GNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKER---IAYGMIKDAedkglitpGKSTLIEATSGNTGIGLAFIGAAKG 93
Cdd:COG0498 65 GGTPLVKAPRLADELGKNLYVKEEGHNPTGSFKDRamqVAVSLALER--------GAKTIVCASSGNGSAALAAYAARAG 136
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 18397061 94 YKVVLTMPSS-MSLERKIILLALGAEVHLtdpskgVQGIIDKAEEICSK 141
Cdd:COG0498 137 IEVFVFVPEGkVSPGQLAQMLTYGAHVIA------VDGNFDDAQRLVKE 179
|
|
| PRK06450 |
PRK06450 |
threonine synthase; Validated |
17-119 |
1.73e-04 |
|
threonine synthase; Validated
Pssm-ID: 180565 [Multi-domain] Cd Length: 338 Bit Score: 42.80 E-value: 1.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 17 GNTPMVYLNNIvdgcvariAAKLEMMEPCSSVKERIAYGMIKDAEDKGLitpgkSTLIEATSGNTGIGLAFIGAAKGYKV 96
Cdd:PRK06450 57 GRTPLIKKGNI--------WFKLDFLNPTGSYKDRGSVTLISYLAEKGI-----KQISEDSSGNAGASIAAYGAAAGIEV 123
|
90 100
....*....|....*....|...
gi 18397061 97 VLTMPSSMSLERKIILLALGAEV 119
Cdd:PRK06450 124 KIFVPETASGGKLKQIESYGAEV 146
|
|
| PRK06110 |
PRK06110 |
threonine dehydratase; |
68-119 |
1.27e-03 |
|
threonine dehydratase;
Pssm-ID: 235699 Cd Length: 322 Bit Score: 39.98 E-value: 1.27e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 18397061 68 PGKSTLIEATSGNTGIGLAFIGAAKGYKVVLTMPSSMSLERKIILLALGAEV 119
Cdd:PRK06110 68 PRVRGVISATRGNHGQSVAFAARRHGLAATIVVPHGNSVEKNAAMRALGAEL 119
|
|
| PLN02550 |
PLN02550 |
threonine dehydratase |
10-213 |
2.17e-03 |
|
threonine dehydratase
Pssm-ID: 178165 [Multi-domain] Cd Length: 591 Bit Score: 39.52 E-value: 2.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 10 DDATQLIGNTPMVYLNNIVDGCVARIAA--------------------KLEMMEPCSSVKERIAYGMI----KDAEDKGL 65
Cdd:PLN02550 81 NEAENGSIPEAMEYLTNILSAKVYDVAIesplqlakklserlgvkvllKREDLQPVFSFKLRGAYNMMaklpKEQLDKGV 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397061 66 ITpgkstlieATSGNTGIGLAFIGAAKGYKVVLTMPSSM------SLERkiillaLGAEVHLTDPSkgvqgiIDKAE--- 136
Cdd:PLN02550 161 IC--------SSAGNHAQGVALSAQRLGCDAVIAMPVTTpeikwqSVER------LGATVVLVGDS------YDEAQaya 220
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18397061 137 EICSKNPDSIMLEQFKNPsNPQTHYRTTGPEIWRDSAGEVDILVAGVGTGGTLSGSGRFLKEKNKDFKVYGVEPTES 213
Cdd:PLN02550 221 KQRALEEGRTFIPPFDHP-DVIAGQGTVGMEIVRQHQGPLHAIFVPVGGGGLIAGIAAYVKRVRPEVKIIGVEPSDA 296
|
|
| PRK08206 |
PRK08206 |
diaminopropionate ammonia-lyase; Provisional |
69-123 |
5.24e-03 |
|
diaminopropionate ammonia-lyase; Provisional
Pssm-ID: 236186 Cd Length: 399 Bit Score: 38.32 E-value: 5.24e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 18397061 69 GKSTLIEATSGNTGIGLAFiGAAK-GYKVVLTMPSSMSLERKIILLALGAEVHLTD 123
Cdd:PRK08206 115 GDITFATATDGNHGRGVAW-AAQQlGQKAVIYMPKGSSEERVDAIRALGAECIITD 169
|
|
| |
