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Conserved domains on  [gi|18398265|ref|NP_566334|]
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D-alanine-D-alanine ligase family [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DdlA COG1181
D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, ...
 78-454 1.24e-64

D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, General function prediction only]; D-alanine-D-alanine ligase or related ATP-grasp enzyme is part of the Pathway/BioSystem: Mureine biosynthesis


:

Pssm-ID: 440794 [Multi-domain]  Cd Length: 303  Bit Score: 212.27  E-value: 1.24e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265  78 LRVGLICGGPSAERGISLNSARSVLDHIQGDGINVSCYYIDPDlkafaissaqvysntpsdfDFkleslaqgfssLSELA 157
Cdd:COG1181   1 MRVAVLFGGRSAEREVSLKSGRAVAAALDKAGYDVVPIGIDVE-------------------DL-----------PAALK 50

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265 158 EHlvsAVDIVFPVIHGRFGEDGGIQELLESHNIPFVGTGSRECFRAFDKYEASLELKELGFmTVPNYLVqgtgVDKSEIA 237
Cdd:COG1181  51 EL---KPDVVFPALHGRGGEDGTIQGLLELLGIPYTGSGVLASALAMDKALTKRVLAAAGL-PTPPYVV----LRRGELA 122

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265 238 LWftdNQLDLEMGK-VVVKPAKAGSSIGVKVAFGVNDsIKKATELILEgIDDRVVVEVFIeDAYEFTAIVLDVGsgsvcH 316
Cdd:COG1181 123 DL---EAIEEELGLpLFVKPAREGSSVGVSKVKNAEE-LAAALEEAFK-YDDKVLVEEFI-DGREVTVGVLGNG-----G 191

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265 317 PVVLMPTEVQlqfhgigdpKENAIFDYRRKYLPtQQVTYHTPPRFPIHVIKSIREEASLIFQKLGLRDFARIDGWYlapn 396
Cdd:COG1181 192 PRALPPIEIV---------PENGFYDYEAKYTD-GGTEYICPARLPEELEERIQELALKAFRALGCRGYARVDFRL---- 257

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 18398265 397 snlsspvsetlggTKSGDIIFTDINLISGMEQTSFLFQQASKVGFSHSNILRTIVHRA 454
Cdd:COG1181 258 -------------DEDGEPYLLEVNTLPGMTPTSLLPKAAAAAGISYEELIERIIELA 302
Dala_Dala_lig_N super family cl29461
D-ala D-ala ligase N-terminus; This family represents the N-terminal region of the ...
 486-514 4.90e-07

D-ala D-ala ligase N-terminus; This family represents the N-terminal region of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4 which is thought to be involved in substrate binding. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF). This domain is structurally related to the PreATP-grasp domain.


The actual alignment was detected with superfamily member pfam01820:

Pssm-ID: 460346 [Multi-domain]  Cd Length: 118  Bit Score: 48.37  E-value: 4.90e-07
                          10        20
                  ....*....|....*....|....*....
gi 18398265   486 KVFVIFGGDTSERQVSVMSGTNVWVNLQR 514
Cdd:pfam01820   1 KVAVLFGGRSSEHEVSLVSARSVLKALDK 29
 
Name Accession Description Interval E-value
DdlA COG1181
D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, ...
 78-454 1.24e-64

D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, General function prediction only]; D-alanine-D-alanine ligase or related ATP-grasp enzyme is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440794 [Multi-domain]  Cd Length: 303  Bit Score: 212.27  E-value: 1.24e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265  78 LRVGLICGGPSAERGISLNSARSVLDHIQGDGINVSCYYIDPDlkafaissaqvysntpsdfDFkleslaqgfssLSELA 157
Cdd:COG1181   1 MRVAVLFGGRSAEREVSLKSGRAVAAALDKAGYDVVPIGIDVE-------------------DL-----------PAALK 50

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265 158 EHlvsAVDIVFPVIHGRFGEDGGIQELLESHNIPFVGTGSRECFRAFDKYEASLELKELGFmTVPNYLVqgtgVDKSEIA 237
Cdd:COG1181  51 EL---KPDVVFPALHGRGGEDGTIQGLLELLGIPYTGSGVLASALAMDKALTKRVLAAAGL-PTPPYVV----LRRGELA 122

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265 238 LWftdNQLDLEMGK-VVVKPAKAGSSIGVKVAFGVNDsIKKATELILEgIDDRVVVEVFIeDAYEFTAIVLDVGsgsvcH 316
Cdd:COG1181 123 DL---EAIEEELGLpLFVKPAREGSSVGVSKVKNAEE-LAAALEEAFK-YDDKVLVEEFI-DGREVTVGVLGNG-----G 191

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265 317 PVVLMPTEVQlqfhgigdpKENAIFDYRRKYLPtQQVTYHTPPRFPIHVIKSIREEASLIFQKLGLRDFARIDGWYlapn 396
Cdd:COG1181 192 PRALPPIEIV---------PENGFYDYEAKYTD-GGTEYICPARLPEELEERIQELALKAFRALGCRGYARVDFRL---- 257

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 18398265 397 snlsspvsetlggTKSGDIIFTDINLISGMEQTSFLFQQASKVGFSHSNILRTIVHRA 454
Cdd:COG1181 258 -------------DEDGEPYLLEVNTLPGMTPTSLLPKAAAAAGISYEELIERIIELA 302
ddl PRK01966
D-alanine--D-alanine ligase;
74-442 3.97e-47

D-alanine--D-alanine ligase;


Pssm-ID: 234993 [Multi-domain]  Cd Length: 333  Bit Score: 166.83  E-value: 3.97e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265   74 MSKsLRVGLICGGPSAERGISLNSARSVLDHIQGDGINVSCYYIDPDlkafaissAQVYSNTPSDFDFKLESLAQGFSSL 153
Cdd:PRK01966   1 MMK-MRVALLFGGRSAEHEVSLVSAKSVLKALDKEKYEVVPIGITKD--------GRWYLIDADNMELADDDNDKEDLSL 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265  154 SELAEHLVSAVDIVFPVIHGRFGEDGGIQELLESHNIPFVGTGSRECFRAFDKYEASLELKELGFMTVPnYLVqgtgVDK 233
Cdd:PRK01966  72 LILPSGGSEEVDVVFPVLHGPPGEDGTIQGLLELLGIPYVGCGVLASALSMDKILTKRLLAAAGIPVAP-YVV----LTR 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265  234 SEIALWFTDNQLD-LEMGkVVVKPAKAGSSIGV-KVafgvndsiKKATELI--LE---GIDDRVVVEVFIeDAYEFTAIV 306
Cdd:PRK01966 147 GDWEEASLAEIEAkLGLP-VFVKPANLGSSVGIsKV--------KNEEELAaaLDlafEYDRKVLVEQGI-KGREIECAV 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265  307 LDVgsgsvcHPVVLMPTEVQlqfhgigdpKENAIFDYRRKYLPtQQVTYHTPPRFPIHVIKSIREEASLIFQKLGLRDFA 386
Cdd:PRK01966 217 LGN------DPKASVPGEIV---------KPDDFYDYEAKYLD-GSAELIIPADLSEELTEKIRELAIKAFKALGCSGLA 280

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 18398265  387 RIDGWYlapnsnlsspvsetlggTKSGDIIFTDINLISGMEQTSF--LFQQASKVGFS 442
Cdd:PRK01966 281 RVDFFL-----------------TEDGEIYLNEINTMPGFTPISMypKLWEASGLSYP 321
D_ala_D_alaTIGR TIGR01205
D-alanine--D-alanine ligase; This model describes D-Ala--D-Ala ligase, an enzyme that makes a ...
 79-451 9.58e-46

D-alanine--D-alanine ligase; This model describes D-Ala--D-Ala ligase, an enzyme that makes a required precursor of the bacterial cell wall. It also describes some closely related proteins responsible for resistance to glycopeptide antibiotics such as vancomycin. The mechanism of glyopeptide antibiotic resistance involves the production of D-alanine-D-lactate (VanA and VanB families) or D-alanine-D-serine (VanC). The seed alignment contains only chromosomally encoded D-ala--D-ala ligases, but a number of antibiotic resistance proteins score above the trusted cutoff of this model. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273498 [Multi-domain]  Cd Length: 315  Bit Score: 162.45  E-value: 9.58e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265    79 RVGLICGGPSAERGISLNSARSVLDHIQGDGINVscYYIDPDlkafaissaQVYSNTPSDFdfkleslAQGFSSLSELAE 158
Cdd:TIGR01205   1 RVAVLFGGKSAEHEISLVSAAAVLKALRDLGYDV--YPVDID---------KMGSWTYKDL-------PQLILELGALLE 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265   159 hlvsAVDIVFPVIHGRFGEDGGIQELLESHNIPFVGTGSRECFRAFDKYEASLELKELGFMTVPNYLVQGTGVDKSEIAL 238
Cdd:TIGR01205  63 ----GIDVVFPVLHGRYGEDGTIQGLLELMGIPYTGSGVLASALSMDKLLTKLLWKALGLPTPDYIVLTQNRASADELEC 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265   239 WFTDNQLDLEMgkvVVKPAKAGSSIGVKVAFGVNDsIKKATELILEgIDDRVVVEVFIEdAYEFTAIVLDVGSG-SVCHP 317
Cdd:TIGR01205 139 EQVAEPLGFPV---IVKPAREGSSVGVSKVKSEEE-LQAALDEAFE-YDEEVLVEQFIK-GRELEVSILGNEEAlPIIEI 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265   318 VvlmptevqlqfhgigdPKENAIFDYRRKYL--PTQqvtYHTPPRFPIHVIKSIREEASLIFQKLGLRDFARIDGWYlap 395
Cdd:TIGR01205 213 V----------------PEIEGFYDYEAKYLdgSTE---YVIPAPLDEELEEKIKELALKAYKALGCRGLARVDFFL--- 270

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 18398265   396 nsnlsspvsetlggTKSGDIIFTDINLISGMEQTSFLFQQASKVGFSHSNILRTIV 451
Cdd:TIGR01205 271 --------------DEEGEIYLNEINTIPGMTAISLFPKAAAAAGIEFSQLVERIL 312
Dala_Dala_lig_N pfam01820
D-ala D-ala ligase N-terminus; This family represents the N-terminal region of the ...
 79-194 1.41e-33

D-ala D-ala ligase N-terminus; This family represents the N-terminal region of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4 which is thought to be involved in substrate binding. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF). This domain is structurally related to the PreATP-grasp domain.


Pssm-ID: 460346 [Multi-domain]  Cd Length: 118  Bit Score: 123.10  E-value: 1.41e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265    79 RVGLICGGPSAERGISLNSARSVLDHIQGDGINVSCYYIDPDLKAFAISSAQVYSNTPSDFDFKLESLA-QGFSSLSELA 157
Cdd:pfam01820   1 KVAVLFGGRSSEHEVSLVSARSVLKALDKEKYEVIPIGITKDGRLGEAALRELASDDGLLLEVDDAPDGgPAGLLFGPNV 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 18398265   158 EHLVSAVDIVFPVIHGRFGEDGGIQELLESHNIPFVG 194
Cdd:pfam01820  81 LELLIEVDVVFPVLHGPNGEDGTLQGLLELAGIPYVG 117
Dala_Dala_lig_N pfam01820
D-ala D-ala ligase N-terminus; This family represents the N-terminal region of the ...
 486-514 4.90e-07

D-ala D-ala ligase N-terminus; This family represents the N-terminal region of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4 which is thought to be involved in substrate binding. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF). This domain is structurally related to the PreATP-grasp domain.


Pssm-ID: 460346 [Multi-domain]  Cd Length: 118  Bit Score: 48.37  E-value: 4.90e-07
                          10        20
                  ....*....|....*....|....*....
gi 18398265   486 KVFVIFGGDTSERQVSVMSGTNVWVNLQR 514
Cdd:pfam01820   1 KVAVLFGGRSSEHEVSLVSARSVLKALDK 29
ddl PRK01372
D-alanine--D-alanine ligase; Reviewed
 486-514 2.91e-03

D-alanine--D-alanine ligase; Reviewed


Pssm-ID: 234948 [Multi-domain]  Cd Length: 304  Bit Score: 39.71  E-value: 2.91e-03
                         10        20
                 ....*....|....*....|....*....
gi 18398265  486 KVFVIFGGDTSERQVSVMSGTNVWVNLQR 514
Cdd:PRK01372   6 KVAVLMGGTSAEREVSLNSGAAVLAALRE 34
 
Name Accession Description Interval E-value
DdlA COG1181
D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, ...
 78-454 1.24e-64

D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, General function prediction only]; D-alanine-D-alanine ligase or related ATP-grasp enzyme is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440794 [Multi-domain]  Cd Length: 303  Bit Score: 212.27  E-value: 1.24e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265  78 LRVGLICGGPSAERGISLNSARSVLDHIQGDGINVSCYYIDPDlkafaissaqvysntpsdfDFkleslaqgfssLSELA 157
Cdd:COG1181   1 MRVAVLFGGRSAEREVSLKSGRAVAAALDKAGYDVVPIGIDVE-------------------DL-----------PAALK 50

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265 158 EHlvsAVDIVFPVIHGRFGEDGGIQELLESHNIPFVGTGSRECFRAFDKYEASLELKELGFmTVPNYLVqgtgVDKSEIA 237
Cdd:COG1181  51 EL---KPDVVFPALHGRGGEDGTIQGLLELLGIPYTGSGVLASALAMDKALTKRVLAAAGL-PTPPYVV----LRRGELA 122

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265 238 LWftdNQLDLEMGK-VVVKPAKAGSSIGVKVAFGVNDsIKKATELILEgIDDRVVVEVFIeDAYEFTAIVLDVGsgsvcH 316
Cdd:COG1181 123 DL---EAIEEELGLpLFVKPAREGSSVGVSKVKNAEE-LAAALEEAFK-YDDKVLVEEFI-DGREVTVGVLGNG-----G 191

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265 317 PVVLMPTEVQlqfhgigdpKENAIFDYRRKYLPtQQVTYHTPPRFPIHVIKSIREEASLIFQKLGLRDFARIDGWYlapn 396
Cdd:COG1181 192 PRALPPIEIV---------PENGFYDYEAKYTD-GGTEYICPARLPEELEERIQELALKAFRALGCRGYARVDFRL---- 257

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 18398265 397 snlsspvsetlggTKSGDIIFTDINLISGMEQTSFLFQQASKVGFSHSNILRTIVHRA 454
Cdd:COG1181 258 -------------DEDGEPYLLEVNTLPGMTPTSLLPKAAAAAGISYEELIERIIELA 302
ddl PRK01966
D-alanine--D-alanine ligase;
74-442 3.97e-47

D-alanine--D-alanine ligase;


Pssm-ID: 234993 [Multi-domain]  Cd Length: 333  Bit Score: 166.83  E-value: 3.97e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265   74 MSKsLRVGLICGGPSAERGISLNSARSVLDHIQGDGINVSCYYIDPDlkafaissAQVYSNTPSDFDFKLESLAQGFSSL 153
Cdd:PRK01966   1 MMK-MRVALLFGGRSAEHEVSLVSAKSVLKALDKEKYEVVPIGITKD--------GRWYLIDADNMELADDDNDKEDLSL 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265  154 SELAEHLVSAVDIVFPVIHGRFGEDGGIQELLESHNIPFVGTGSRECFRAFDKYEASLELKELGFMTVPnYLVqgtgVDK 233
Cdd:PRK01966  72 LILPSGGSEEVDVVFPVLHGPPGEDGTIQGLLELLGIPYVGCGVLASALSMDKILTKRLLAAAGIPVAP-YVV----LTR 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265  234 SEIALWFTDNQLD-LEMGkVVVKPAKAGSSIGV-KVafgvndsiKKATELI--LE---GIDDRVVVEVFIeDAYEFTAIV 306
Cdd:PRK01966 147 GDWEEASLAEIEAkLGLP-VFVKPANLGSSVGIsKV--------KNEEELAaaLDlafEYDRKVLVEQGI-KGREIECAV 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265  307 LDVgsgsvcHPVVLMPTEVQlqfhgigdpKENAIFDYRRKYLPtQQVTYHTPPRFPIHVIKSIREEASLIFQKLGLRDFA 386
Cdd:PRK01966 217 LGN------DPKASVPGEIV---------KPDDFYDYEAKYLD-GSAELIIPADLSEELTEKIRELAIKAFKALGCSGLA 280

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 18398265  387 RIDGWYlapnsnlsspvsetlggTKSGDIIFTDINLISGMEQTSF--LFQQASKVGFS 442
Cdd:PRK01966 281 RVDFFL-----------------TEDGEIYLNEINTMPGFTPISMypKLWEASGLSYP 321
D_ala_D_alaTIGR TIGR01205
D-alanine--D-alanine ligase; This model describes D-Ala--D-Ala ligase, an enzyme that makes a ...
 79-451 9.58e-46

D-alanine--D-alanine ligase; This model describes D-Ala--D-Ala ligase, an enzyme that makes a required precursor of the bacterial cell wall. It also describes some closely related proteins responsible for resistance to glycopeptide antibiotics such as vancomycin. The mechanism of glyopeptide antibiotic resistance involves the production of D-alanine-D-lactate (VanA and VanB families) or D-alanine-D-serine (VanC). The seed alignment contains only chromosomally encoded D-ala--D-ala ligases, but a number of antibiotic resistance proteins score above the trusted cutoff of this model. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273498 [Multi-domain]  Cd Length: 315  Bit Score: 162.45  E-value: 9.58e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265    79 RVGLICGGPSAERGISLNSARSVLDHIQGDGINVscYYIDPDlkafaissaQVYSNTPSDFdfkleslAQGFSSLSELAE 158
Cdd:TIGR01205   1 RVAVLFGGKSAEHEISLVSAAAVLKALRDLGYDV--YPVDID---------KMGSWTYKDL-------PQLILELGALLE 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265   159 hlvsAVDIVFPVIHGRFGEDGGIQELLESHNIPFVGTGSRECFRAFDKYEASLELKELGFMTVPNYLVQGTGVDKSEIAL 238
Cdd:TIGR01205  63 ----GIDVVFPVLHGRYGEDGTIQGLLELMGIPYTGSGVLASALSMDKLLTKLLWKALGLPTPDYIVLTQNRASADELEC 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265   239 WFTDNQLDLEMgkvVVKPAKAGSSIGVKVAFGVNDsIKKATELILEgIDDRVVVEVFIEdAYEFTAIVLDVGSG-SVCHP 317
Cdd:TIGR01205 139 EQVAEPLGFPV---IVKPAREGSSVGVSKVKSEEE-LQAALDEAFE-YDEEVLVEQFIK-GRELEVSILGNEEAlPIIEI 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265   318 VvlmptevqlqfhgigdPKENAIFDYRRKYL--PTQqvtYHTPPRFPIHVIKSIREEASLIFQKLGLRDFARIDGWYlap 395
Cdd:TIGR01205 213 V----------------PEIEGFYDYEAKYLdgSTE---YVIPAPLDEELEEKIKELALKAYKALGCRGLARVDFFL--- 270

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 18398265   396 nsnlsspvsetlggTKSGDIIFTDINLISGMEQTSFLFQQASKVGFSHSNILRTIV 451
Cdd:TIGR01205 271 --------------DEEGEIYLNEINTIPGMTAISLFPKAAAAAGIEFSQLVERIL 312
ddl PRK01372
D-alanine--D-alanine ligase; Reviewed
 74-451 9.87e-36

D-alanine--D-alanine ligase; Reviewed


Pssm-ID: 234948 [Multi-domain]  Cd Length: 304  Bit Score: 135.24  E-value: 9.87e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265   74 MSKSLRVGLICGGPSAERGISLNSARSVLDHIQGDGINVscYYIDPDlkafaissaqvysntpsdfDFKLESL-AQGFss 152
Cdd:PRK01372   1 PKMFGKVAVLMGGTSAEREVSLNSGAAVLAALREAGYDA--HPIDPG-------------------EDIAAQLkELGF-- 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265  153 lselaehlvsavDIVFPVIHGRFGEDGGIQELLESHNIPFVGTGSRECFRAFDKYEASLELKELGfMTVPNYLVqgtgVD 232
Cdd:PRK01372  58 ------------DRVFNALHGRGGEDGTIQGLLELLGIPYTGSGVLASALAMDKLRTKLVWQAAG-LPTPPWIV----LT 120

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265  233 KSEIalwftDNQLDLEMG-KVVVKPAKAGSSIGVKVAFGVNDsIKKATELILEgIDDRVVVEVFIEDAyEFTAIVLDvgs 311
Cdd:PRK01372 121 REED-----LLAAIDKLGlPLVVKPAREGSSVGVSKVKEEDE-LQAALELAFK-YDDEVLVEKYIKGR-ELTVAVLG--- 189

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265  312 gsvchPVVLMPTEVQLqfhgigdpkENAIFDYRRKYLP--TQqvtYHTPPRFPIHVIKSIREEASLIFQKLGLRDFARID 389
Cdd:PRK01372 190 -----GKALPVIEIVP---------AGEFYDYEAKYLAggTQ---YICPAGLPAEIEAELQELALKAYRALGCRGWGRVD 252

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18398265  390 GWYlapnsnlsspvsetlggTKSGDIIFTDINLISGMEQTSFLFQQASKVGFSHSNILRTIV 451
Cdd:PRK01372 253 FML-----------------DEDGKPYLLEVNTQPGMTSHSLVPMAARAAGISFSELVDRIL 297
Dala_Dala_lig_N pfam01820
D-ala D-ala ligase N-terminus; This family represents the N-terminal region of the ...
 79-194 1.41e-33

D-ala D-ala ligase N-terminus; This family represents the N-terminal region of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4 which is thought to be involved in substrate binding. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF). This domain is structurally related to the PreATP-grasp domain.


Pssm-ID: 460346 [Multi-domain]  Cd Length: 118  Bit Score: 123.10  E-value: 1.41e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265    79 RVGLICGGPSAERGISLNSARSVLDHIQGDGINVSCYYIDPDLKAFAISSAQVYSNTPSDFDFKLESLA-QGFSSLSELA 157
Cdd:pfam01820   1 KVAVLFGGRSSEHEVSLVSARSVLKALDKEKYEVIPIGITKDGRLGEAALRELASDDGLLLEVDDAPDGgPAGLLFGPNV 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 18398265   158 EHLVSAVDIVFPVIHGRFGEDGGIQELLESHNIPFVG 194
Cdd:pfam01820  81 LELLIEVDVVFPVLHGPNGEDGTLQGLLELAGIPYVG 117
PRK14571 PRK14571
D-alanyl-alanine synthetase A; Provisional
 78-455 2.30e-26

D-alanyl-alanine synthetase A; Provisional


Pssm-ID: 184751 [Multi-domain]  Cd Length: 299  Bit Score: 108.76  E-value: 2.30e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265   78 LRVGLICGGPSAERGISLNSARSVLDHIQGDGINVSCYYIDpdlkafaissaqvysntpSDFDFKLESLAQgfsslsela 157
Cdd:PRK14571   1 MRVALLMGGVSREREISLRSGERVKKALEKLGYEVTVFDVD------------------EDFLKKVDQLKS--------- 53

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265  158 ehlvsaVDIVFPVIHGRFGEDGGIQELLESHNIPFVGTGSRECFRAFDKYEASLELKelGFMTVPNYLVQGTGVDKSEIA 237
Cdd:PRK14571  54 ------FDVVFNVLHGTFGEDGTLQAILDFLGIRYTGSDAFSSMICFDKLLTYRFLK--GTVEIPDFVEIKEFMKTSPLG 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265  238 LwftdnqldlemgKVVVKPAKAGSSIGVKVAFGVN---DSIKKATELIlegidDRVVVEVFIEdAYEFTAIVLDVGSGsv 314
Cdd:PRK14571 126 Y------------PCVVKPRREGSSIGVFICESDEefqHALKEDLPRY-----GSVIVQEYIP-GREMTVSILETEKG-- 185

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265  315 chPVVLMPTEVQlqfhgigdPKENaIFDYRRKYlpTQQVT-YHTPPRFPIHVIKSIREEASLIFQKLGLRDFARIDGWYl 393
Cdd:PRK14571 186 --FEVLPILELR--------PKRR-FYDYVAKY--TKGETeFILPAPLNPEEERLVKETALKAFVEAGCRGFGRVDGIF- 251

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18398265  394 apnsnlsspvsetlggtKSGDIIFTDINLISGMEQTSFLFQQASKVGFSHSNILRTIVHRAC 455
Cdd:PRK14571 252 -----------------SDGRFYFLEINTVPGLTELSDLPASAKAGGIEFEELVDIIIKSAF 296
PRK14570 PRK14570
D-alanyl-alanine synthetase A; Provisional
 74-454 6.50e-24

D-alanyl-alanine synthetase A; Provisional


Pssm-ID: 173034 [Multi-domain]  Cd Length: 364  Bit Score: 102.99  E-value: 6.50e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265   74 MSKSLRvgLICGGPSAERGISLNSARSV-LDHIQGDGINVSCYYIDPDLKAFAISSAQVYSNTPSDFD-FKLESLAQGFS 151
Cdd:PRK14570   1 MKKNLM--LIFGGVSFEHEISLRSAYGIySALLKLDKYNIYSVFIDKCTGIWYLLDSVPDPPKLIKRDvLPIVSLIPGCG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265  152 SLSElAEHLvsAVDIVFPVIHGRFGEDGGIQELLESHNIPFVGTGSRECFRAFDKYEASLELKELGFMTVP-------NY 224
Cdd:PRK14570  79 IFVN-NKNL--EIDVVFPIVHGRTGEDGAIQGFLKVMDIPCVGAGILGSAISINKYFCKLLLKSFNIPLVPfigfrkyDY 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265  225 LVQGTGVDKSeialwfTDNQLDLemgKVVVKPAKAGSSIGVKVAFGVNdSIKKATELILEgIDDRVVVEVFIEdAYEFTA 304
Cdd:PRK14570 156 FLDKEGIKKD------IKEVLGY---PVIVKPAVLGSSIGINVAYNEN-QIEKCIEEAFK-YDLTVVIEKFIE-AREIEC 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265  305 IVldVGSGSVchpVVLMPTEVQLQfhgigdpkENAIFDYRRKY--LPTQQVTYHTPPRFPIHVIKSIREEASLIFQKLGL 382
Cdd:PRK14570 224 SV--IGNEQI---KIFTPGEIVVQ--------DFIFYDYDAKYstIPGNSIVFNIPAHLDTKHLLDIKEYAFLTYKNLEL 290

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18398265  383 RDFARIDgwylapnsnlsspvseTLGGTKSGDIIFTDINLISGMEQTSFLFQQASKVGFSHSNILRTIVHRA 454
Cdd:PRK14570 291 RGMARID----------------FLIEKDTGLIYLNEINTIPGFTDISMFAKMCEHDGLQYKSLVDNLIDLA 346
PRK14573 PRK14573
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
57-458 4.78e-19

bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;


Pssm-ID: 184752 [Multi-domain]  Cd Length: 809  Bit Score: 90.65  E-value: 4.78e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265   57 GSGAIRTVSKAVGYGQemSKSLRVGLICGGPSAERGISLNSARSVLDHIQgdginvSCYYidpDLKAFAISSAQVYSnTP 136
Cdd:PRK14573 433 GAGNIYTLGEALKDFE--PKKLSLGLVCGGKSCEHDISLLSAKNIAKYLS------PEFY---DVSYFLINRQGLWE-TV 500

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265  137 SDFDFKLESlAQGFSSLS-ELAEHLvSAVDIVFPVIHGRFGEDGGIQELLESHNIPFVGTGSRECFRAFDKYEASLELKE 215
Cdd:PRK14573 501 SSLETAIEE-DSGKSVLSsEIAQAL-AKVDVVLPILHGPFGEDGTMQGFLEIIGKPYTGPSLAFSAIAMDKVLTKRFASD 578

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265  216 LGFMTVPnYLvqgtgvdksEIALWFTDNQLDLEMGKVV--------VKPAKAGSSIGVkvaFGVNDSIK---KATELILE 284
Cdd:PRK14573 579 VGVPVVP-YQ---------PLTLAGWKREPELCLAHIVeafsfpmfVKTAHLGSSIGV---FEVHNVEElrdKISEAFLY 645

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265  285 GIDdrvvveVFIEDAY----EFTAIVLDVGSGSVChpvvlmptevqlqfhgIGDPKE----NAIFDYRRKY----LPTQQ 352
Cdd:PRK14573 646 DTD------VFVEESRlgsrEIEVSCLGDGSSAYV----------------IAGPHErrgsGGFIDYQEKYglsgKSSAQ 703

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265  353 VTYHTppRFPIHVIKSIREEASLIFQKLGLRDFARIDgWYLapnsnlsspvsetlggTKSGDIIFTDINLISGMEQTSFL 432
Cdd:PRK14573 704 IVFDL--DLSKESQEQVLELAERIYRLLQGKGSCRID-FFL----------------DEEGNFWLSEMNPIPGMTEASPF 764

                        410       420
                 ....*....|....*....|....*.
gi 18398265  433 FQQASKVGFSHSNILRTIVHRACSRF 458
Cdd:PRK14573 765 LTAFVRKGWTYEQIVHQLIIDGLHKF 790
Dala_Dala_lig_C pfam07478
D-ala D-ala ligase C-terminus; This family represents the C-terminal, catalytic domain of the ...
 252-451 2.92e-18

D-ala D-ala ligase C-terminus; This family represents the C-terminal, catalytic domain of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF).


Pssm-ID: 429483 [Multi-domain]  Cd Length: 204  Bit Score: 83.13  E-value: 2.92e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265   252 VVVKPAKAGSSIGVKVAFGVNDsIKKATELILEgIDDRVVVEVFIEdAYEFTAIVLDVGSgsvchPVVLMPTEVQLQfhg 331
Cdd:pfam07478  39 VFVKPARLGSSVGVSKVESREE-LQAAIEEAFQ-YDEKVLVEEGIE-GREIECAVLGNED-----PEVSPVGEIVPS--- 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265   332 igdpkeNAIFDYRRKYLPTqQVTYHTPPRFPIHVIKSIREEASLIFQKLGLRDFARIDGWYlapnsnlsspvsetlggTK 411
Cdd:pfam07478 108 ------GGFYDYEAKYIDD-SAQIVVPADLEEEQEEQIQELALKAYKALGCRGLARVDFFL-----------------TE 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 18398265   412 SGDIIFTDINLISGMEQTSFLFQQASKVGFSHSNILRTIV 451
Cdd:pfam07478 164 DGEIVLNEVNTIPGFTSISMFPKLAAAAGVSFPDLVDQLI 203
PRK14572 PRK14572
D-alanyl-alanine synthetase A; Provisional
 79-442 4.45e-17

D-alanyl-alanine synthetase A; Provisional


Pssm-ID: 173036 [Multi-domain]  Cd Length: 347  Bit Score: 82.65  E-value: 4.45e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265   79 RVGLICGGPSAERGISLNSARSVLDHIQGDGINVSCYYIDPDLK-----AFAISSAQVYSNTPSDFdfklESLAQGFSSL 153
Cdd:PRK14572   3 KIAVFFGGSSTEHSISIRTGCFICATLHTMGHSVKPILLTPDGGwvvptVYRPSIPDESGNSEDLF----LEEFQKANGV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265  154 SELAEHLVSAVDIVFPVIHGRFGEDGGIQELLESHNIPFVGTGSRECFRAFDKYEASLELKELGFMTVPNYLVQGTGVDK 233
Cdd:PRK14572  79 SEPADISQLDADIAFLGLHGGAGEDGRIQGFLDTLGIPYTGSGVLASALAMDKTRANQIFLQSGQKVAPFFELEKLKYLN 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265  234 SEIAlwfTDNQLDLEMGKVVVKPAKAGSSIGVKVAfGVNDSIKKATELILEGiDDRVVVEVFIEdAYEFTAIVLDVGSGS 313
Cdd:PRK14572 159 SPRK---TLLKLESLGFPQFLKPVEGGSSVSTYKI-TNAEQLMTLLALIFES-DSKVMSQSFLS-GTEVSCGVLERYRGG 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265  314 VCHPVVLMPTEVQlqfhgigdPKeNAIFDYRRKYlpTQQVTYH-TPPRFPIHVIKSIREEASLIFQKLGLRDFARIDgwY 392
Cdd:PRK14572 233 KRNPIALPATEIV--------PG-GEFFDFESKY--KQGGSEEiTPARISDQEMKRVQELAIRAHESLGCKGYSRTD--F 299

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 18398265  393 LAPNsnlsspvsetlggtksGDIIFTDINLISGMEQTSFLFQQASKVGFS 442
Cdd:PRK14572 300 IIVD----------------GEPHILETNTLPGMTETSLIPQQAKAAGIN 333
AccC COG0439
Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway ...
 183-384 2.04e-08

Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440208 [Multi-domain]  Cd Length: 263  Bit Score: 55.26  E-value: 2.04e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265 183 ELLESHNIPFVGTGSRECFRafDKYEASLELKELGFMTVPNYLVQgtgvDKSEIALWFTDNQLDlemgkVVVKPAKAGSS 262
Cdd:COG0439  34 ELAEELGLPGPSPEAIRAMR--DKVLMREALAAAGVPVPGFALVD----SPEEALAFAEEIGYP-----VVVKPADGAGS 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265 263 IGVKVAFGVNDsIKKATELILEGI-----DDRVVVEVFIE-DAYEFTAIVLDvGsgsvcHPVVLmptevqlqfhgigdpk 336
Cdd:COG0439 103 RGVRVVRDEEE-LEAALAEARAEAkagspNGEVLVEEFLEgREYSVEGLVRD-G-----EVVVC---------------- 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 18398265 337 enAIFDYRRKYLPTQQVTYHTPPRFPIHVIKSIREEASLIFQKLGLRD 384
Cdd:COG0439 160 --SITRKHQKPPYFVELGHEAPSPLPEELRAEIGELVARALRALGYRR 205
Dala_Dala_lig_N pfam01820
D-ala D-ala ligase N-terminus; This family represents the N-terminal region of the ...
 486-514 4.90e-07

D-ala D-ala ligase N-terminus; This family represents the N-terminal region of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4 which is thought to be involved in substrate binding. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF). This domain is structurally related to the PreATP-grasp domain.


Pssm-ID: 460346 [Multi-domain]  Cd Length: 118  Bit Score: 48.37  E-value: 4.90e-07
                          10        20
                  ....*....|....*....|....*....
gi 18398265   486 KVFVIFGGDTSERQVSVMSGTNVWVNLQR 514
Cdd:pfam01820   1 KVAVLFGGRSSEHEVSLVSARSVLKALDK 29
PRK14569 PRK14569
D-alanyl-alanine synthetase A; Provisional
 76-454 8.24e-07

D-alanyl-alanine synthetase A; Provisional


Pssm-ID: 173033 [Multi-domain]  Cd Length: 296  Bit Score: 50.83  E-value: 8.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265   76 KSLRVGLICGGPSAERGISLNSARSVLDHIQGDGinvscyyidpdlkafaissaqvysntpsdfdfkLESLAQGFSSLSE 155
Cdd:PRK14569   2 KNEKIVVLYGGDSPEREVSLKSGKAVLDSLISQG---------------------------------YDAVGVDASGKEL 48

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265  156 LAEHLVSAVDIVFPVIHGRFGEDGGIQELLESHNIPFVGTGSRECFRAFDKYEASLELKELGFMTVPNYLVQGTGVDKSE 235
Cdd:PRK14569  49 VAKLLELKPDKCFVALHGEDGENGRVSALLEMLEIKHTSSSMKSSVITMDKMISKEILMHHRMPTPMAKFLTDKLVAEDE 128

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265  236 IALwftdnqldlemgKVVVKPAKAGSSIG---VKVAFGVNDSIKKATELilegiddrvvVEVFIEDAYEFTAIVLDVGSG 312
Cdd:PRK14569 129 ISF------------PVAVKPSSGGSSIAtfkVKSIQELKHAYEEASKY----------GEVMIEQWVTGKEITVAIVND 186

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265  313 SVCHPVVLMPtevqlqfhgigdpkENAIFDYRRKYlpTQQVTYHTPPRFPIHVIKSIREEASLIFQKLGLRDFARIDGWY 392
Cdd:PRK14569 187 EVYSSVWIEP--------------QNEFYDYESKY--SGKSIYHSPSGLCEQKELEVRQLAKKAYDLLGCSGHARVDFIY 250

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18398265  393 lapnsnlsspvsetlggTKSGDIIFTDINLISGMEQTSFLFQQASKVGFSHSNILRTIVHRA 454
Cdd:PRK14569 251 -----------------DDRGNFYIMEINSSPGMTDNSLSPKSAAAEGVDFDSFVKRIIEQA 295
PRK12767 PRK12767
carbamoyl phosphate synthase-like protein; Provisional
 203-320 7.83e-05

carbamoyl phosphate synthase-like protein; Provisional


Pssm-ID: 237195 [Multi-domain]  Cd Length: 326  Bit Score: 44.87  E-value: 7.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398265  203 AFDKYEASLELKELGFMTVPNYLVQgtgvDKSEIALWFTDNQLDLemgKVVVKPAKAGSSIGVkvaFGVNDsiKKATELI 282
Cdd:PRK12767 109 CNDKWLTYEFLKENGIPTPKSYLPE----SLEDFKAALAKGELQF---PLFVKPRDGSASIGV---FKVND--KEELEFL 176

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 18398265  283 LEGIDDRVVVEvFIEDaYEFTAIVLDVGSGSVCHPVVL 320
Cdd:PRK12767 177 LEYVPNLIIQE-FIEG-QEYTVDVLCDLNGEVISIVPR 212
ddl PRK01372
D-alanine--D-alanine ligase; Reviewed
 486-514 2.91e-03

D-alanine--D-alanine ligase; Reviewed


Pssm-ID: 234948 [Multi-domain]  Cd Length: 304  Bit Score: 39.71  E-value: 2.91e-03
                         10        20
                 ....*....|....*....|....*....
gi 18398265  486 KVFVIFGGDTSERQVSVMSGTNVWVNLQR 514
Cdd:PRK01372   6 KVAVLMGGTSAEREVSLNSGAAVLAALRE 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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