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Conserved domains on  [gi|18399690|ref|NP_566429|]
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A20/AN1-like zinc finger family protein [Arabidopsis thaliana]

Protein Classification

AN1-type zinc finger protein( domain architecture ID 10639988)

AN1-type zinc finger protein similar to plant zinc finger AN1 domain-containing stress-associated proteins that may be involved in environmental stress response

CATH:  4.10.1110.10
Gene Ontology:  GO:0008270
PubMed:  12665246|11179890|17210253
SCOP:  4003945

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnF_AN1 smart00154
AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in ...
 101-138 8.82e-14

AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in Xenopus laevis.


:

Pssm-ID: 197545  Cd Length: 39  Bit Score: 61.64  E-value: 8.82e-14
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 18399690    101 CSGCRKKVGLTGFRCR-CGELFCSEHRYSDRHDCSYDYK 138
Cdd:smart00154   1 CHFCRKKVGLTGFKCRhCGNLFCGEHRLPEDHDCPGDYK 39
 
Name Accession Description Interval E-value
ZnF_AN1 smart00154
AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in ...
 101-138 8.82e-14

AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in Xenopus laevis.


Pssm-ID: 197545  Cd Length: 39  Bit Score: 61.64  E-value: 8.82e-14
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 18399690    101 CSGCRKKVGLTGFRCR-CGELFCSEHRYSDRHDCSYDYK 138
Cdd:smart00154   1 CHFCRKKVGLTGFKCRhCGNLFCGEHRLPEDHDCPGDYK 39
CUZ1 COG3582
CDC48-associated ubiquitin-like protein CUZ1, contains AN1-type Zn-finger (protection from As ...
 99-134 1.02e-07

CDC48-associated ubiquitin-like protein CUZ1, contains AN1-type Zn-finger (protection from As/Sb toxicity) [Defense mechanisms];


Pssm-ID: 442801 [Multi-domain]  Cd Length: 279  Bit Score: 49.91  E-value: 1.02e-07
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 18399690  99 NRCSGCRKKVGLTgFRCR-CGELFCSEHRYSDRHDCS 134
Cdd:COG3582   2 AKCDICGKEENLP-YQCRyCGGTFCSEHRLPENHDCP 37
zf-AN1 pfam01428
AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in ...
 101-135 4.42e-07

AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in Xenopus laevis. The following pattern describes the zinc finger. C-X2-C-X(9-12)-C-X(1-2)-C-X4-C-X2-H-X5-H-X-C Where X can be any amino acid, and numbers in brackets indicate the number of residues.


Pssm-ID: 460208  Cd Length: 37  Bit Score: 44.22  E-value: 4.42e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 18399690   101 CS--GCRKKVGLTgFRCR-CGELFCSEHRYSDRHDCSY 135
Cdd:pfam01428   1 CSfkGCKKKDFLP-FKCRfCGKNFCLKHRLPEDHDCSG 37
FYVE1_Vac1p_like cd15761
FYVE-related domain 1 found in yeast protein VAC1 (Vac1p) and similar proteins; Vac1p, also ...
 99-125 3.02e-03

FYVE-related domain 1 found in yeast protein VAC1 (Vac1p) and similar proteins; Vac1p, also termed vacuolar segregation protein Pep7p, or carboxypeptidase Y-deficient protein 7, or vacuolar protein sorting-associated protein 19 (Vps19p), or vacuolar protein-targeting protein 19, is a phosphatidylinositol 3-phosphate (PtdIns3P or PI3P)-binding protein that interacts with a Rab GTPase, GTP-bound form of Vps21p, and a Sec1p homologue, Vps45p, to facilitate Vps45p-dependent vesicle-mediated vacuolar protein sorting. It also acts as a novel regulator of vesicle docking and/or fusion at the endosome and functions in vesicle-mediated transport of Golgi precursor carboxypeptidase Y (CPY), protease A (PrA), protease B (PrB), but not alkaline phosphatase (ALP) from the trans-Golgi network-like compartment (TGN) to the endosome. Vac1p contains an N-terminal classical TFIIIA-like zinc finger, two putative zinc-binding FYVE fingers, and a C-terminal coiled coil region. The family corresponds to the first FYVE domain, which resembles the FYVE-related domain as it has an altered sequence in the basic ligand binding patch.


Pssm-ID: 277300  Cd Length: 76  Bit Score: 34.94  E-value: 3.02e-03
                        10        20        30
                ....*....|....*....|....*....|
gi 18399690  99 NRCSGCRKKVG-LTGFR-CR-CGELFCSEH 125
Cdd:cd15761  11 SRCSECGKTLNkKNGIVnCRkCGELFCNEH 40
 
Name Accession Description Interval E-value
ZnF_AN1 smart00154
AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in ...
 101-138 8.82e-14

AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in Xenopus laevis.


Pssm-ID: 197545  Cd Length: 39  Bit Score: 61.64  E-value: 8.82e-14
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 18399690    101 CSGCRKKVGLTGFRCR-CGELFCSEHRYSDRHDCSYDYK 138
Cdd:smart00154   1 CHFCRKKVGLTGFKCRhCGNLFCGEHRLPEDHDCPGDYK 39
CUZ1 COG3582
CDC48-associated ubiquitin-like protein CUZ1, contains AN1-type Zn-finger (protection from As ...
 99-134 1.02e-07

CDC48-associated ubiquitin-like protein CUZ1, contains AN1-type Zn-finger (protection from As/Sb toxicity) [Defense mechanisms];


Pssm-ID: 442801 [Multi-domain]  Cd Length: 279  Bit Score: 49.91  E-value: 1.02e-07
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 18399690  99 NRCSGCRKKVGLTgFRCR-CGELFCSEHRYSDRHDCS 134
Cdd:COG3582   2 AKCDICGKEENLP-YQCRyCGGTFCSEHRLPENHDCP 37
zf-AN1 pfam01428
AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in ...
 101-135 4.42e-07

AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in Xenopus laevis. The following pattern describes the zinc finger. C-X2-C-X(9-12)-C-X(1-2)-C-X4-C-X2-H-X5-H-X-C Where X can be any amino acid, and numbers in brackets indicate the number of residues.


Pssm-ID: 460208  Cd Length: 37  Bit Score: 44.22  E-value: 4.42e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 18399690   101 CS--GCRKKVGLTgFRCR-CGELFCSEHRYSDRHDCSY 135
Cdd:pfam01428   1 CSfkGCKKKDFLP-FKCRfCGKNFCLKHRLPEDHDCSG 37
FYVE1_Vac1p_like cd15761
FYVE-related domain 1 found in yeast protein VAC1 (Vac1p) and similar proteins; Vac1p, also ...
 99-125 3.02e-03

FYVE-related domain 1 found in yeast protein VAC1 (Vac1p) and similar proteins; Vac1p, also termed vacuolar segregation protein Pep7p, or carboxypeptidase Y-deficient protein 7, or vacuolar protein sorting-associated protein 19 (Vps19p), or vacuolar protein-targeting protein 19, is a phosphatidylinositol 3-phosphate (PtdIns3P or PI3P)-binding protein that interacts with a Rab GTPase, GTP-bound form of Vps21p, and a Sec1p homologue, Vps45p, to facilitate Vps45p-dependent vesicle-mediated vacuolar protein sorting. It also acts as a novel regulator of vesicle docking and/or fusion at the endosome and functions in vesicle-mediated transport of Golgi precursor carboxypeptidase Y (CPY), protease A (PrA), protease B (PrB), but not alkaline phosphatase (ALP) from the trans-Golgi network-like compartment (TGN) to the endosome. Vac1p contains an N-terminal classical TFIIIA-like zinc finger, two putative zinc-binding FYVE fingers, and a C-terminal coiled coil region. The family corresponds to the first FYVE domain, which resembles the FYVE-related domain as it has an altered sequence in the basic ligand binding patch.


Pssm-ID: 277300  Cd Length: 76  Bit Score: 34.94  E-value: 3.02e-03
                        10        20        30
                ....*....|....*....|....*....|
gi 18399690  99 NRCSGCRKKVG-LTGFR-CR-CGELFCSEH 125
Cdd:cd15761  11 SRCSECGKTLNkKNGIVnCRkCGELFCNEH 40
FYVE_scVPS27p_like cd15760
FYVE domain found in Saccharomyces cerevisiae vacuolar protein sorting-associated protein 27 ...
 99-125 5.65e-03

FYVE domain found in Saccharomyces cerevisiae vacuolar protein sorting-associated protein 27 (scVps27p) and similar proteins; scVps27p, also termed Golgi retention defective protein 11, is the putative yeast counterpart of the mammalian protein Hrs and is involved in endosome maturation. It is a mono-ubiquitin-binding protein that interacts with ubiquitinated cargoes, such as Hse1p, and is required for protein sorting into the multivesicular body. Vps27p forms a complex with Hse1p. The complex binds ubiquitin and mediates endosomal protein sorting. At the endosome, Vps27p and a trimeric protein complex, ESCRT-1, bind ubiquitin and are important for multivesicular body (MVB) sorting. Vps27p contains an N-terminal VHS (Vps27/Hrs/STAM) domain, a FYVE domain that binds PtdIns3P, followed by two ubiquitin-interacting motifs (UIMs), and a C-terminal clathrin-binding motif.


Pssm-ID: 277299 [Multi-domain]  Cd Length: 59  Bit Score: 33.81  E-value: 5.65e-03
                        10        20        30
                ....*....|....*....|....*....|
gi 18399690  99 NRCSGCRKKVGLTGFR--CR-CGELFCSEH 125
Cdd:cd15760   6 SRCDVCRKKFGLFKRRhhCRnCGDSFCSEH 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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