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Conserved domains on  [gi|18401203|ref|NP_566557|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 162-456 2.17e-94

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 287.31  E-value: 2.17e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203 162 NYRVLQGHLGWVRSVAFDPSNEWFCTGSADRTIKIWDVATGVLKLTLTGHIGQVRGLAVSNRHTYMFSAGDDKQVKCWDL 241
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203 242 EQNKVIRSYHGHLHGVYCLALHPTLDVVLTGGRDSVCRVWDIRTKMQIFVLP-HDSDVFSVLARPTDPQVITGSHDSTIK 320
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203 321 FWDLRYGKSMATITNHKKTVRAMALHPKENDFVSASADNIKKFSLPKGEFCHNMLSLQRDIINAVAVNEDGVMVTGGDKG 400
Cdd:cd00200 161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 18401203 401 G-LWFWDWKSGhnfQRAETIVQPgslesEAGIYAACYDQTGSRLVTCEGDKTIKMWK 456
Cdd:cd00200 241 GtIRVWDLRTG---ECVQTLSGH-----TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 162-456 2.17e-94

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 287.31  E-value: 2.17e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203 162 NYRVLQGHLGWVRSVAFDPSNEWFCTGSADRTIKIWDVATGVLKLTLTGHIGQVRGLAVSNRHTYMFSAGDDKQVKCWDL 241
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203 242 EQNKVIRSYHGHLHGVYCLALHPTLDVVLTGGRDSVCRVWDIRTKMQIFVLP-HDSDVFSVLARPTDPQVITGSHDSTIK 320
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203 321 FWDLRYGKSMATITNHKKTVRAMALHPKENDFVSASADNIKKFSLPKGEFCHNMLSLQRDIINAVAVNEDGVMVTGGDKG 400
Cdd:cd00200 161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 18401203 401 G-LWFWDWKSGhnfQRAETIVQPgslesEAGIYAACYDQTGSRLVTCEGDKTIKMWK 456
Cdd:cd00200 241 GtIRVWDLRTG---ECVQTLSGH-----TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
164-455 6.25e-61

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 204.37  E-value: 6.25e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203 164 RVLQGHLGWVRSVAFDPSNEWFCTGSADRTIKIWDVATGVLKLTLTGHIGQVRGLAVSNRHTYMFSAGDDKQVKCWDLEQ 243
Cdd:COG2319 114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT 193

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203 244 NKVIRSYHGHLHGVYCLALHPTLDVVLTGGRDSVCRVWDIRTKMQIFVLP-HDSDVFSVLARPTDPQVITGSHDSTIKFW 322
Cdd:COG2319 194 GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSPDGRLLASGSADGTVRLW 273

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203 323 DLRYGKSMATITNHKKTVRAMALHPKENDFVSASADN-IKKFSLPKGEfCHNMLSLQRDIINAVAVNEDG-VMVTGGDKG 400
Cdd:COG2319 274 DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGtVRLWDLATGK-LLRTLTGHTGAVRSVAFSPDGkTLASGSDDG 352

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 18401203 401 GLWFWDWKSGhnfQRAETIVQPgslesEAGIYAACYDQTGSRLVTCEGDKTIKMW 455
Cdd:COG2319 353 TVRLWDLATG---ELLRTLTGH-----TGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 pfam00400
WD domain, G-beta repeat;
160-198 2.23e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 55.43  E-value: 2.23e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 18401203   160 WKNYRVLQGHLGWVRSVAFDPSNEWFCTGSADRTIKIWD 198
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 159-198 2.83e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.40  E-value: 2.83e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 18401203    159 PWKNYRVLQGHLGWVRSVAFDPSNEWFCTGSADRTIKIWD 198
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 166-328 2.20e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 56.44  E-value: 2.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203  166 LQGHLGWVRSVAFDPS-NEWFCTGSADRTIKIWDVATGVLKLTLTGHIGQVRGLAVSNRHTYMFSAGDDKQVKCWDLEQN 244
Cdd:PTZ00421 121 LQGHTKKVGIVSFHPSaMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203  245 KVIRSYHGHLHG-----VYClalhPTLDVVLTGGRDSV----CRVWDIRtKMQIFVLPHDSDVFSVLARP-----TDPQV 310
Cdd:PTZ00421 201 TIVSSVEAHASAksqrcLWA----KRKDLIITLGCSKSqqrqIMLWDTR-KMASPYSTVDLDQSSALFIPffdedTNLLY 275

                        170
                 ....*....|....*...
gi 18401203  311 ITGSHDSTIKFWDLRYGK 328
Cdd:PTZ00421 276 IGSKGEGNIRCFELMNER 293
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 162-456 2.17e-94

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 287.31  E-value: 2.17e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203 162 NYRVLQGHLGWVRSVAFDPSNEWFCTGSADRTIKIWDVATGVLKLTLTGHIGQVRGLAVSNRHTYMFSAGDDKQVKCWDL 241
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203 242 EQNKVIRSYHGHLHGVYCLALHPTLDVVLTGGRDSVCRVWDIRTKMQIFVLP-HDSDVFSVLARPTDPQVITGSHDSTIK 320
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203 321 FWDLRYGKSMATITNHKKTVRAMALHPKENDFVSASADNIKKFSLPKGEFCHNMLSLQRDIINAVAVNEDGVMVTGGDKG 400
Cdd:cd00200 161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 18401203 401 G-LWFWDWKSGhnfQRAETIVQPgslesEAGIYAACYDQTGSRLVTCEGDKTIKMWK 456
Cdd:cd00200 241 GtIRVWDLRTG---ECVQTLSGH-----TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
164-455 6.25e-61

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 204.37  E-value: 6.25e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203 164 RVLQGHLGWVRSVAFDPSNEWFCTGSADRTIKIWDVATGVLKLTLTGHIGQVRGLAVSNRHTYMFSAGDDKQVKCWDLEQ 243
Cdd:COG2319 114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT 193

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203 244 NKVIRSYHGHLHGVYCLALHPTLDVVLTGGRDSVCRVWDIRTKMQIFVLP-HDSDVFSVLARPTDPQVITGSHDSTIKFW 322
Cdd:COG2319 194 GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSPDGRLLASGSADGTVRLW 273

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203 323 DLRYGKSMATITNHKKTVRAMALHPKENDFVSASADN-IKKFSLPKGEfCHNMLSLQRDIINAVAVNEDG-VMVTGGDKG 400
Cdd:COG2319 274 DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGtVRLWDLATGK-LLRTLTGHTGAVRSVAFSPDGkTLASGSDDG 352

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 18401203 401 GLWFWDWKSGhnfQRAETIVQPgslesEAGIYAACYDQTGSRLVTCEGDKTIKMW 455
Cdd:COG2319 353 TVRLWDLATG---ELLRTLTGH-----TGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
164-409 5.55e-56

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.66  E-value: 5.55e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203 164 RVLQGHLGWVRSVAFDPSNEWFCTGSADRTIKIWDVATGVLKLTLTGHIGQVRGLAVSNRHTYMFSAGDDKQVKCWDLEQ 243
Cdd:COG2319 156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203 244 NKVIRSYHGHLHGVYCLALHPTLDVVLTGGRDSVCRVWDIRTKMQIFVLPHDSD-VFSVLARPTDPQVITGSHDSTIKFW 322
Cdd:COG2319 236 GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGgVNSVAFSPDGKLLASGSDDGTVRLW 315

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203 323 DLRYGKSMATITNHKKTVRAMALHPKENDFVSASADN-IKKFSLPKGEfCHNMLSLQRDIINAVAVNEDG-VMVTGGDKG 400
Cdd:COG2319 316 DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGtVRLWDLATGE-LLRTLTGHTGAVTSVAFSPDGrTLASGSADG 394


                ....*....
gi 18401203 401 GLWFWDWKS 409
Cdd:COG2319 395 TVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
94-455 5.91e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 188.97  E-value: 5.91e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203  94 LRKSATEKALVVGPTLPPRDLNNTGNPGKSTAILPAPGSFSERNLSTAALMERMPSRWPRPEWHAPWKNYRVLQGHLGWV 173
Cdd:COG2319   2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203 174 RSVAFDPSNEWFCTGSADRTIKIWDVATGVLKLTLTGHIGQVRGLAVSNRHTYMFSAGDDKQVKCWDLEQNKVIRSYHGH 253
Cdd:COG2319  82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGH 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203 254 LHGVYCLALHPTLDVVLTGGRDSVCRVWDIRTKMQIFVLP-HDSDVFSVLARPTDPQVITGSHDSTIKFWDLRYGKSMAT 332
Cdd:COG2319 162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRT 241

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203 333 ITNHKKTVRAMALHPKENDFVSASADN-IKKFSLPKGEfCHNMLSLQRDIINAVAVNEDG-VMVTGGDKGGLWFWDWKSG 410
Cdd:COG2319 242 LTGHSGSVRSVAFSPDGRLLASGSADGtVRLWDLATGE-LLRTLTGHSGGVNSVAFSPDGkLLASGSDDGTVRLWDLATG 320

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*
gi 18401203 411 HNFQRAEtivqpgslESEAGIYAACYDQTGSRLVTCEGDKTIKMW 455
Cdd:COG2319 321 KLLRTLT--------GHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
177-455 1.35e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.11  E-value: 1.35e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203 177 AFDPSNEWFCTGSADRTIKIWDVATGVLKLTLTGHIGQVRGLAVSNRHTYMFSAGDDKQVKCWDLEQNKVIRSYHGHLHG 256
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203 257 VYCLALHPTLDVVLTGGRDSVCRVWDIRTKMQIFVL-PHDSDVFSVLARPTDPQVITGSHDSTIKFWDLRYGKSMATITN 335
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLtGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203 336 HKKTVRAMALHPKENDFVSASADN-IKKFSLPKGEFCHNmLSLQRDIINAVAVNEDG-VMVTGGDKGGLWFWDWKSGHNF 413
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGtVRLWDLATGKLLRT-LTGHTGAVRSVAFSPDGkLLASGSADGTVRLWDLATGKLL 239

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 18401203 414 QRAETivqpgsleSEAGIYAACYDQTGSRLVTCEGDKTIKMW 455
Cdd:COG2319 240 RTLTG--------HSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 pfam00400
WD domain, G-beta repeat;
160-198 2.23e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 55.43  E-value: 2.23e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 18401203   160 WKNYRVLQGHLGWVRSVAFDPSNEWFCTGSADRTIKIWD 198
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 159-198 2.83e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.40  E-value: 2.83e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 18401203    159 PWKNYRVLQGHLGWVRSVAFDPSNEWFCTGSADRTIKIWD 198
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 166-328 2.20e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 56.44  E-value: 2.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203  166 LQGHLGWVRSVAFDPS-NEWFCTGSADRTIKIWDVATGVLKLTLTGHIGQVRGLAVSNRHTYMFSAGDDKQVKCWDLEQN 244
Cdd:PTZ00421 121 LQGHTKKVGIVSFHPSaMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203  245 KVIRSYHGHLHG-----VYClalhPTLDVVLTGGRDSV----CRVWDIRtKMQIFVLPHDSDVFSVLARP-----TDPQV 310
Cdd:PTZ00421 201 TIVSSVEAHASAksqrcLWA----KRKDLIITLGCSKSqqrqIMLWDTR-KMASPYSTVDLDQSSALFIPffdedTNLLY 275

                        170
                 ....*....|....*...
gi 18401203  311 ITGSHDSTIKFWDLRYGK 328
Cdd:PTZ00421 276 IGSKGEGNIRCFELMNER 293
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 243-282 1.55e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.55e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 18401203    243 QNKVIRSYHGHLHGVYCLALHPTLDVVLTGGRDSVCRVWD 282
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
244-282 7.24e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 7.24e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 18401203   244 NKVIRSYHGHLHGVYCLALHPTLDVVLTGGRDSVCRVWD 282
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 77-363 1.62e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.86  E-value: 1.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203   77 TAPLKALALPGPKGSKELRKSatEKALVVGPTLPPRDLNNTGNPGKstAILPapgsFSE---RNLSTAALMERMPSRwpr 153
Cdd:PLN00181 407 AAAEKPLARYYSALSENGRSS--EKSSMSNPAKPPDFYINDSRQGG--WIDP----FLEglcKYLSFSKLRVKADLK--- 475

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203  154 pewhapwknyrvlQGHL----GWVRSVAFDPSNEWFCTGSADRTIKIW----------DVATGVLKLTLTGHIGQVrgLA 219
Cdd:PLN00181 476 -------------QGDLlnssNLVCAIGFDRDGEFFATAGVNKKIKIFecesiikdgrDIHYPVVELASRSKLSGI--CW 540

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203  220 VSNRHTYMFSAGDDKQVKCWDLEQNKVIRSYHGHLHGVYCL---ALHPTLdvVLTGGRDSVCRVWDIRTKMQIFVLPHDS 296
Cdd:PLN00181 541 NSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIdysSADPTL--LASGSDDGSVKLWSINQGVSIGTIKTKA 618

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18401203  297 DVFSV-LARPTDPQVITGSHDSTIKFWDLRYGK-SMATITNHKKTVRAMALhPKENDFVSASADNIKKF 363
Cdd:PLN00181 619 NICCVqFPSESGRSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKL 686
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 201-240 1.81e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.81e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 18401203    201 TGVLKLTLTGHIGQVRGLAVSNRHTYMFSAGDDKQVKCWD 240
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
202-240 1.32e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.32e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 18401203   202 GVLKLTLTGHIGQVRGLAVSNRHTYMFSAGDDKQVKCWD 240
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 165-325 2.86e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 43.34  E-value: 2.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203  165 VLQGHLGWVRSVAFDP-SNEWFCTGSADRTIKIWDVATGVLKLTLTGHIGQVRG----LAVSNRH----TYMFSAGDDKQ 235
Cdd:PTZ00421  70 ILLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGhtkkVGIVSFHpsamNVLASAGADMV 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401203  236 VKCWDLEQNK---VIRSyhghlHGVYCLALHPTLDVVL--TGGRDSVCRVWDirtkmqifvlPHDSDVFS---------- 300
Cdd:PTZ00421 150 VNVWDVERGKaveVIKC-----HSDQITSLEWNLDGSLlcTTSKDKKLNIID----------PRDGTIVSsveahasaks 214

                        170       180       190
                 ....*....|....*....|....*....|.
gi 18401203  301 ---VLARPTDPQVITG---SHDSTIKFWDLR 325
Cdd:PTZ00421 215 qrcLWAKRKDLIITLGcskSQQRQIMLWDTR 245
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 294-323 3.98e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 3.98e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 18401203    294 HDSDVFSVLARPTDPQVITGSHDSTIKFWD 323
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
294-323 5.12e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 5.12e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 18401203   294 HDSDVFSVLARPTDPQVITGSHDSTIKFWD 323
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 240-286 5.98e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 38.75  E-value: 5.98e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 18401203 240 DLEQNKVIRSYHGHLHG-VYCLALHPTLDVVLTGGRDSVCRVWDIRTK 286
Cdd:cd22857 251 DLRTGKLLGCFKGKCGGsIRSIARHPELPLIASCGLDRYLRIWDTETR 298
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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