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Conserved domains on  [gi|18403467|ref|NP_566714|]
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cupin family protein [Arabidopsis thaliana]

Protein Classification

vicilin family protein( domain architecture ID 14388890)

vicilin family protein is a cupin domain-containing protein similar to 7S seed storage proteins, such as cupincin, beta-conglycinin, vicilin, provicilin, canavalin, convicilin, and conglutin beta, and Ara h 1, a major peanut allergen

CATH:  2.60.120.10
Gene Ontology:  GO:0045735
PubMed:  19478949|14697267|9573603
SCOP:  3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cupin_7S_vicilin-like_N cd02244
7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal ...
 74-253 3.22e-67

7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal domains of plant 7S seed storage proteins such as vicilin, and includes beta-conglycinin, phaseolin, canavalin, conglutin-beta, a chromatin protein in Pisum sativum called P54, and a sucrose binding protein in soybean called SBP. These 7S globulins also include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2, and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The vicilin peptides formed by trypsin or chymotrypsin digestion exhibit antihypertensive effects. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


:

Pssm-ID: 380371  Cd Length: 178  Bit Score: 213.52  E-value: 3.22e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467  74 WFQSKEGFVRVLPKFTKHAPaLFRGIENYRFSLVEMEPTTFFVPHHLDADAVFIVLQGKGVIEFVTDKTKESFHITKGDV 153
Cdd:cd02244   1 VVRTEAGEIRVLERFDGRSR-LLRGIENYRLAFITMEPNTLFLPHHLDADMVFYVHTGRGTITWVDEDKRESYNLERGDV 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467 154 VRIPSGVTNFITNTNQTVPLRLAQITVPVN--NPGNYKDYFPAASQFQQSYFNGFTKEVLSTSFNVPEELLGRLVTRSKe 231
Cdd:cd02244  80 YRIPAGSTFYLVNTDENEKLRIIALFDPVNslTPGPFQSFFGAGGQNPESLLSGFSKEILEAAFNVSEEELERLLSQQK- 158

                       170       180
                ....*....|....*....|..
gi 18403467 232 igQGIIRRISPDQIKELAEHAT 253
Cdd:cd02244 159 --PGPIVKASEEQIRALSRHAS 178
cupin_7S_vicilin-like_C cd02245
7S vicilin seed storage globulin, C-terminal cupin domain; This family contains C-terminal ...
 285-457 4.92e-62

7S vicilin seed storage globulin, C-terminal cupin domain; This family contains C-terminal domain of plant 7S seed storage protein such as vicilin and includes beta-conglycinin, phaseolin, canavalin, conglutin-beta, a chromatin protein in Pisum sativum called P54, and a sucrose binding protein in soybean called SBP. These 7S globulins also include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2 and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The vicilin peptides formed by trypsin or chymotrypsin digestion exhibit antihypertensive effects. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


:

Pssm-ID: 380372  Cd Length: 166  Bit Score: 199.67  E-value: 4.92e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467 285 PIYSNDFGHFHEAHPKNYNQLQDLHIAAAWANMTQGSLFLPHFNSKTTFVTFVENGCARFEMATPYKFqrgqqqwpGQGQ 364
Cdd:cd02245   1 PDFSNQYGWLYEADPEDYKQLKDLDVGVSFVNITQGSMMAPHYNSRATEIAVVVEGEGYVEMVCPHLS--------SQSQ 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467 365 EEEEDMSENVHKVVSRVCKGEVFIVPAGHPFTIL-SQDQDFIAVGFGIYATNSKRTFLAGEENLLSNLNPAATRVTFGVG 443
Cdd:cd02245  73 QGEEEGSGEYQKVRARLSEGDVFVVPAGHPVAQVaSSNENLEFVGFGINAQNNERQFLAGKNNVLRQLDREAKELAFNVP 152

                       170
                ....*....|....
gi 18403467 444 SKVAEKLFTSQNYS 457
Cdd:cd02245 153 AEEVEEVLNAQDES 166
 
Name Accession Description Interval E-value
cupin_7S_vicilin-like_N cd02244
7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal ...
 74-253 3.22e-67

7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal domains of plant 7S seed storage proteins such as vicilin, and includes beta-conglycinin, phaseolin, canavalin, conglutin-beta, a chromatin protein in Pisum sativum called P54, and a sucrose binding protein in soybean called SBP. These 7S globulins also include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2, and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The vicilin peptides formed by trypsin or chymotrypsin digestion exhibit antihypertensive effects. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380371  Cd Length: 178  Bit Score: 213.52  E-value: 3.22e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467  74 WFQSKEGFVRVLPKFTKHAPaLFRGIENYRFSLVEMEPTTFFVPHHLDADAVFIVLQGKGVIEFVTDKTKESFHITKGDV 153
Cdd:cd02244   1 VVRTEAGEIRVLERFDGRSR-LLRGIENYRLAFITMEPNTLFLPHHLDADMVFYVHTGRGTITWVDEDKRESYNLERGDV 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467 154 VRIPSGVTNFITNTNQTVPLRLAQITVPVN--NPGNYKDYFPAASQFQQSYFNGFTKEVLSTSFNVPEELLGRLVTRSKe 231
Cdd:cd02244  80 YRIPAGSTFYLVNTDENEKLRIIALFDPVNslTPGPFQSFFGAGGQNPESLLSGFSKEILEAAFNVSEEELERLLSQQK- 158

                       170       180
                ....*....|....*....|..
gi 18403467 232 igQGIIRRISPDQIKELAEHAT 253
Cdd:cd02244 159 --PGPIVKASEEQIRALSRHAS 178
cupin_7S_vicilin-like_C cd02245
7S vicilin seed storage globulin, C-terminal cupin domain; This family contains C-terminal ...
 285-457 4.92e-62

7S vicilin seed storage globulin, C-terminal cupin domain; This family contains C-terminal domain of plant 7S seed storage protein such as vicilin and includes beta-conglycinin, phaseolin, canavalin, conglutin-beta, a chromatin protein in Pisum sativum called P54, and a sucrose binding protein in soybean called SBP. These 7S globulins also include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2 and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The vicilin peptides formed by trypsin or chymotrypsin digestion exhibit antihypertensive effects. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380372  Cd Length: 166  Bit Score: 199.67  E-value: 4.92e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467 285 PIYSNDFGHFHEAHPKNYNQLQDLHIAAAWANMTQGSLFLPHFNSKTTFVTFVENGCARFEMATPYKFqrgqqqwpGQGQ 364
Cdd:cd02245   1 PDFSNQYGWLYEADPEDYKQLKDLDVGVSFVNITQGSMMAPHYNSRATEIAVVVEGEGYVEMVCPHLS--------SQSQ 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467 365 EEEEDMSENVHKVVSRVCKGEVFIVPAGHPFTIL-SQDQDFIAVGFGIYATNSKRTFLAGEENLLSNLNPAATRVTFGVG 443
Cdd:cd02245  73 QGEEEGSGEYQKVRARLSEGDVFVVPAGHPVAQVaSSNENLEFVGFGINAQNNERQFLAGKNNVLRQLDREAKELAFNVP 152

                       170
                ....*....|....
gi 18403467 444 SKVAEKLFTSQNYS 457
Cdd:cd02245 153 AEEVEEVLNAQDES 166
Cupin_1 smart00835
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 281-448 2.07e-35

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 214845 [Multi-domain]  Cd Length: 146  Bit Score: 128.94  E-value: 2.07e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467    281 FAIDPIYSNDFGHFHEAHPKNYNQLQDLHIAAAWANMTQGSLFLPHFNSKTTFVTFVENGCARFEMATPYKFqrgqqqwp 360
Cdd:smart00835   1 LEPRPDFSNEGGRLREADPTNFPALNGLGISAARVNLEPGGMLPPHYHPRATELLYVVRGEGRVGVVDPNGN-------- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467    361 gqgqeeeedmsenvHKVVSRVCKGEVFIVPAGHPFTIL-SQDQDFIAVGFGIYATNsKRTFLAGEENLLSNLNPAATRVT 439
Cdd:smart00835  73 --------------KVYDARLREGDVFVVPQGHPHFQVnSGDENLEFVAFNTNDPN-RRFFLAGRNSVLRGLPPEVLAAA 137


                   ....*....
gi 18403467    440 FGVGSKVAE 448
Cdd:smart00835 138 FGVSAEEVR 146
Cupin_1 pfam00190
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 278-448 3.00e-22

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 395138  Cd Length: 151  Bit Score: 92.78  E-value: 3.00e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467   278 FNLFAIDPIYSNDFGHFHEAHPKNYNQLQDLHIAAAWANMTQGSLFLPHFNSKTTFVTFVENGCARFEMATPykfqrgqq 357
Cdd:pfam00190   1 LNLLEPGPTYNPEGGRVTTVNSKNLPGLNTLGISAARVDLAPGGMNPPHWHPNATEILYVLQGRGRVGFVVP-------- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467   358 qwpgqgqeeeEDMSENVHKVVSrvcKGEVFIVPAGHPFTILSQDQD--FIAVGFGIYAtNSKRTFLAGEENLLSNLNPAA 435
Cdd:pfam00190  73 ----------GNGNRVFHKVLR---EGDVFVVPQGLPHFQYNIGDEpaVAFVAFDTNN-PGNQSILAGGFSSLPALPPEV 138

                         170
                  ....*....|...
gi 18403467   436 TRVTFGVGSKVAE 448
Cdd:pfam00190 139 LAKAFQLAGEEVK 151
Cupin_1 smart00835
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 75-222 3.42e-15

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 214845 [Multi-domain]  Cd Length: 146  Bit Score: 72.70  E-value: 3.42e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467     75 FQSKEGFVRVLpkFTKHAPALfRGIeNYRFSLVEMEPTTFFVPH-HLDADAVFIVLQGKGVIEFVTDKTKE--SFHITKG 151
Cdd:smart00835   7 FSNEGGRLREA--DPTNFPAL-NGL-GISAARVNLEPGGMLPPHyHPRATELLYVVRGEGRVGVVDPNGNKvyDARLREG 82

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18403467    152 DVVRIPSGVTNFITNTNQTvplRLAQITVPVNNPGnyKDYFPAAsqfQQSYFNGFTKEVLSTSFNVPEELL 222
Cdd:smart00835  83 DVFVVPQGHPHFQVNSGDE---NLEFVAFNTNDPN--RRFFLAG---RNSVLRGLPPEVLAAAFGVSAEEV 145
ManC COG0662
Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];
100-181 8.25e-07

Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];


Pssm-ID: 440426 [Multi-domain]  Cd Length: 114  Bit Score: 47.83  E-value: 8.25e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467 100 ENYRFSLVEMEPTTFFVPH-HLDADAVFIVLQGKGVIEFvtdkTKESFHITKGDVVRIPSGVTNFITNTnQTVPLRLAQI 178
Cdd:COG0662  25 ERLSVKRITVPPGAELSLHvHPHRDEFFYVLEGTGEVTI----GDEEVELKAGDSVYIPAGVPHRLRNP-GDEPLELLEV 99


                ...
gi 18403467 179 TVP 181
Cdd:COG0662 100 QAP 102
Cupin_1 pfam00190
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 107-217 1.46e-06

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 395138  Cd Length: 151  Bit Score: 47.71  E-value: 1.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467   107 VEMEPTTFFVPH-HLDADAVFIVLQGKGVIEFVT---DKTKESFHITKGDVVRIPSGVTNFITNTNQTvPLrLAQITVPV 182
Cdd:pfam00190  38 VDLAPGGMNPPHwHPNATEILYVLQGRGRVGFVVpgnGNRVFHKVLREGDVFVVPQGLPHFQYNIGDE-PA-VAFVAFDT 115

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 18403467   183 NNPGNYKDyfpAASQFqqSYFNGFTKEVLSTSFNV 217
Cdd:pfam00190 116 NNPGNQSI---LAGGF--SSLPALPPEVLAKAFQL 145
PLN00212 PLN00212
glutelin; Provisional
 109-238 1.60e-03

glutelin; Provisional


Pssm-ID: 215106 [Multi-domain]  Cd Length: 493  Bit Score: 40.95  E-value: 1.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467  109 MEPTTFFVPHHLDADAVFIVLQGKGVI----------------EFVTDKTKES------------FHitKGDVVRIPSGV 160
Cdd:PLN00212  87 IEPQGLLLPRYSNTPGLVYIIQGRGSMgltfpgcpatyqqqfqQFLTEGQSQSqkfrdehqkihqFR--QGDVVALPAGV 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467  161 TNFITNTNQTvPLrLAQITVPVNNPGN-----YKDYFPAAS--QFQQSY------------FNGFTKEVLSTSFNVPEEL 221
Cdd:PLN00212 165 AHWFYNDGDA-PV-VALYVYDINNNANqleprQREFLLAGNnnRQQQVYgrsieqhsgqniFSGFSTELLSEALGINAQV 242

                        170
                 ....*....|....*..
gi 18403467  222 LGRLVTRSKEIGQgIIR 238
Cdd:PLN00212 243 AKRLQSQNDQRGE-IIR 258
 
Name Accession Description Interval E-value
cupin_7S_vicilin-like_N cd02244
7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal ...
 74-253 3.22e-67

7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal domains of plant 7S seed storage proteins such as vicilin, and includes beta-conglycinin, phaseolin, canavalin, conglutin-beta, a chromatin protein in Pisum sativum called P54, and a sucrose binding protein in soybean called SBP. These 7S globulins also include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2, and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The vicilin peptides formed by trypsin or chymotrypsin digestion exhibit antihypertensive effects. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380371  Cd Length: 178  Bit Score: 213.52  E-value: 3.22e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467  74 WFQSKEGFVRVLPKFTKHAPaLFRGIENYRFSLVEMEPTTFFVPHHLDADAVFIVLQGKGVIEFVTDKTKESFHITKGDV 153
Cdd:cd02244   1 VVRTEAGEIRVLERFDGRSR-LLRGIENYRLAFITMEPNTLFLPHHLDADMVFYVHTGRGTITWVDEDKRESYNLERGDV 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467 154 VRIPSGVTNFITNTNQTVPLRLAQITVPVN--NPGNYKDYFPAASQFQQSYFNGFTKEVLSTSFNVPEELLGRLVTRSKe 231
Cdd:cd02244  80 YRIPAGSTFYLVNTDENEKLRIIALFDPVNslTPGPFQSFFGAGGQNPESLLSGFSKEILEAAFNVSEEELERLLSQQK- 158

                       170       180
                ....*....|....*....|..
gi 18403467 232 igQGIIRRISPDQIKELAEHAT 253
Cdd:cd02244 159 --PGPIVKASEEQIRALSRHAS 178
cupin_7S_vicilin-like_C cd02245
7S vicilin seed storage globulin, C-terminal cupin domain; This family contains C-terminal ...
 285-457 4.92e-62

7S vicilin seed storage globulin, C-terminal cupin domain; This family contains C-terminal domain of plant 7S seed storage protein such as vicilin and includes beta-conglycinin, phaseolin, canavalin, conglutin-beta, a chromatin protein in Pisum sativum called P54, and a sucrose binding protein in soybean called SBP. These 7S globulins also include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2 and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The vicilin peptides formed by trypsin or chymotrypsin digestion exhibit antihypertensive effects. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380372  Cd Length: 166  Bit Score: 199.67  E-value: 4.92e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467 285 PIYSNDFGHFHEAHPKNYNQLQDLHIAAAWANMTQGSLFLPHFNSKTTFVTFVENGCARFEMATPYKFqrgqqqwpGQGQ 364
Cdd:cd02245   1 PDFSNQYGWLYEADPEDYKQLKDLDVGVSFVNITQGSMMAPHYNSRATEIAVVVEGEGYVEMVCPHLS--------SQSQ 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467 365 EEEEDMSENVHKVVSRVCKGEVFIVPAGHPFTIL-SQDQDFIAVGFGIYATNSKRTFLAGEENLLSNLNPAATRVTFGVG 443
Cdd:cd02245  73 QGEEEGSGEYQKVRARLSEGDVFVVPAGHPVAQVaSSNENLEFVGFGINAQNNERQFLAGKNNVLRQLDREAKELAFNVP 152

                       170
                ....*....|....
gi 18403467 444 SKVAEKLFTSQNYS 457
Cdd:cd02245 153 AEEVEEVLNAQDES 166
Cupin_1 smart00835
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 281-448 2.07e-35

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 214845 [Multi-domain]  Cd Length: 146  Bit Score: 128.94  E-value: 2.07e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467    281 FAIDPIYSNDFGHFHEAHPKNYNQLQDLHIAAAWANMTQGSLFLPHFNSKTTFVTFVENGCARFEMATPYKFqrgqqqwp 360
Cdd:smart00835   1 LEPRPDFSNEGGRLREADPTNFPALNGLGISAARVNLEPGGMLPPHYHPRATELLYVVRGEGRVGVVDPNGN-------- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467    361 gqgqeeeedmsenvHKVVSRVCKGEVFIVPAGHPFTIL-SQDQDFIAVGFGIYATNsKRTFLAGEENLLSNLNPAATRVT 439
Cdd:smart00835  73 --------------KVYDARLREGDVFVVPQGHPHFQVnSGDENLEFVAFNTNDPN-RRFFLAGRNSVLRGLPPEVLAAA 137


                   ....*....
gi 18403467    440 FGVGSKVAE 448
Cdd:smart00835 138 FGVSAEEVR 146
Cupin_1 pfam00190
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 278-448 3.00e-22

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 395138  Cd Length: 151  Bit Score: 92.78  E-value: 3.00e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467   278 FNLFAIDPIYSNDFGHFHEAHPKNYNQLQDLHIAAAWANMTQGSLFLPHFNSKTTFVTFVENGCARFEMATPykfqrgqq 357
Cdd:pfam00190   1 LNLLEPGPTYNPEGGRVTTVNSKNLPGLNTLGISAARVDLAPGGMNPPHWHPNATEILYVLQGRGRVGFVVP-------- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467   358 qwpgqgqeeeEDMSENVHKVVSrvcKGEVFIVPAGHPFTILSQDQD--FIAVGFGIYAtNSKRTFLAGEENLLSNLNPAA 435
Cdd:pfam00190  73 ----------GNGNRVFHKVLR---EGDVFVVPQGLPHFQYNIGDEpaVAFVAFDTNN-PGNQSILAGGFSSLPALPPEV 138

                         170
                  ....*....|...
gi 18403467   436 TRVTFGVGSKVAE 448
Cdd:pfam00190 139 LAKAFQLAGEEVK 151
Cupin_1 smart00835
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 75-222 3.42e-15

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 214845 [Multi-domain]  Cd Length: 146  Bit Score: 72.70  E-value: 3.42e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467     75 FQSKEGFVRVLpkFTKHAPALfRGIeNYRFSLVEMEPTTFFVPH-HLDADAVFIVLQGKGVIEFVTDKTKE--SFHITKG 151
Cdd:smart00835   7 FSNEGGRLREA--DPTNFPAL-NGL-GISAARVNLEPGGMLPPHyHPRATELLYVVRGEGRVGVVDPNGNKvyDARLREG 82

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18403467    152 DVVRIPSGVTNFITNTNQTvplRLAQITVPVNNPGnyKDYFPAAsqfQQSYFNGFTKEVLSTSFNVPEELL 222
Cdd:smart00835  83 DVFVVPQGHPHFQVNSGDE---NLEFVAFNTNDPN--RRFFLAG---RNSVLRGLPPEVLAAAFGVSAEEV 145
cupin_11S_legumin_N cd02242
11S legumin seed storage globulin, N-terminal cupin domain; This family contains the ...
 110-238 3.46e-13

11S legumin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal domains of 11S legumin seed storage proteins that supply nutrition for seed germination, such as glycinin and legumin, including many common food allergens such as the peanut major allergen Ara h 3, almond allergen Pru du 6, Pecan allergen Car i 4, hazelnut nut allergen Cor a 9, Brazil nut allergen Ber e 2, cashew allergen Ana o 2, pistachio allergen Pis v 2/5, and walnut allergen Jug n/r 4. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). They are synthesized as propeptides in the endoplasmic reticulum and transported to the secretory vesicles as a homotrimer. The propeptides are processed as they are sorted in the secretory vesicles. The homotrimer binds another homotrimer to form a homohexamer with 32-point symmetry formed by a face-to-face stacking of the two trimers. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380369  Cd Length: 209  Bit Score: 68.38  E-value: 3.46e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467 110 EPTTFFVPHHLDADAVFIVLQGKGVIEFVTDKTKESF---------------------HITKGDVVRIPSGVTNFITNTN 168
Cdd:cd02242  43 EPRGLLLPSYSNAPKLAYVLQGRGIVGVVFPGCPETFqssqqsqgqgqrfrdqhqkvrRIRKGDVIAVPAGVVHWWYNDG 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467 169 QTvPLRLaqITV-PVNNPGNYKD----YFPAASQFQQSY-------------FNGFTKEVLSTSFNVPEELLGRLVtRSK 230
Cdd:cd02242 123 DS-DLVI--VFLgDTSNNANQLDgnfrRFFLAGNPQQEQqgqgqeqsgggniFSGFSTEFLAEAFGVDEETARKLQ-GSQ 198


                ....*...
gi 18403467 231 EIGQGIIR 238
Cdd:cd02242 199 DQRGLIVK 206
cupin_7S_11S_C cd20285
7S and 11S seed storage globulin, C-terminal cupin domain; This family contains the C-terminal ...
 292-422 1.33e-12

7S and 11S seed storage globulin, C-terminal cupin domain; This family contains the C-terminal cupin domains of 7S and 11S seed storage proteins. The 7S globulins include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2, and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The 11S globulins include many common food allergens such as the peanut major allergen Ara h 3, almond allergen Pru du 6, pecan allergen Car i 4, hazelnut nut allergen Cor a 9, Brazil nut allergen Ber e 2, cashew allergen Ana o 2, pistachio allergen Pis v 2/5, and walnut allergen Jug n/r 4. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380420  Cd Length: 109  Bit Score: 64.17  E-value: 1.33e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467 292 GHFHEAHPKNYNQLQDLHIAAAWANMTQGSLFLPHFNSKTTFVTFVENGCARFEMATPykfqrgqqqwpgqgqEEEEDMS 371
Cdd:cd20285   1 GNVTERTSNDFPILKSLNLLASSISLEEGAMFVPHYYSKAIVILVVNEGRAHIQVVGP---------------KGYESYD 65

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 18403467 372 ENVHkvvsrvcKGEVFIVPAGHPFTILSQDQDFIAVGFGIYATNSKRTFLA 422
Cdd:cd20285  66 AELS-------KGDVFVVPAAFPVAIKSTSHNVEFTGFGTNANNNNRNLLA 109
ManC COG0662
Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];
100-181 8.25e-07

Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];


Pssm-ID: 440426 [Multi-domain]  Cd Length: 114  Bit Score: 47.83  E-value: 8.25e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467 100 ENYRFSLVEMEPTTFFVPH-HLDADAVFIVLQGKGVIEFvtdkTKESFHITKGDVVRIPSGVTNFITNTnQTVPLRLAQI 178
Cdd:COG0662  25 ERLSVKRITVPPGAELSLHvHPHRDEFFYVLEGTGEVTI----GDEEVELKAGDSVYIPAGVPHRLRNP-GDEPLELLEV 99


                ...
gi 18403467 179 TVP 181
Cdd:COG0662 100 QAP 102
Cupin_1 pfam00190
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 107-217 1.46e-06

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 395138  Cd Length: 151  Bit Score: 47.71  E-value: 1.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467   107 VEMEPTTFFVPH-HLDADAVFIVLQGKGVIEFVT---DKTKESFHITKGDVVRIPSGVTNFITNTNQTvPLrLAQITVPV 182
Cdd:pfam00190  38 VDLAPGGMNPPHwHPNATEILYVLQGRGRVGFVVpgnGNRVFHKVLREGDVFVVPQGLPHFQYNIGDE-PA-VAFVAFDT 115

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 18403467   183 NNPGNYKDyfpAASQFqqSYFNGFTKEVLSTSFNV 217
Cdd:pfam00190 116 NNPGNQSI---LAGGF--SSLPALPPEVLAKAFQL 145
OxdD COG2140
Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily [Carbohydrate ...
 103-191 4.00e-06

Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily [Carbohydrate transport and metabolism]; Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 441743 [Multi-domain]  Cd Length: 115  Bit Score: 45.73  E-value: 4.00e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467 103 RFSLVEMEPTTFFVPH-HLDADAVFIVLQGKGVIEFVTDKTK-ESFHITKGDVVRIPSGVTNFITNTNQTvPLRLAQITv 180
Cdd:COG2140   4 AGGLTVLEPGGVREEHwHPNAAEWYYVLSGEARMTVQDPPGRaRTVDVGPGDVVYVPPGYGHYIINTGDE-PLVFLAVF- 81

                        90
                ....*....|.
gi 18403467 181 pvnNPGNYKDY 191
Cdd:COG2140  82 ---DDDAGSDY 89
cupin_PA3510-like cd02225
Pseudomonas aeruginosa PA3510 and related proteins, cupin domain; This family includes ...
 90-160 9.44e-06

Pseudomonas aeruginosa PA3510 and related proteins, cupin domain; This family includes bacterial proteins homologous to PA3510, a Pseudomonas aeruginosa protein of unknown function with a beta-barrel fold that belongs to the cupin superfamily.


Pssm-ID: 380354  Cd Length: 150  Bit Score: 45.34  E-value: 9.44e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18403467  90 KHAPALFRGIENYRFSLVEMEPTTFFVPHHLDADAVFIVLQGKGVIEFVTDKTKESFHITKGDVVRIPSGV 160
Cdd:cd02225  41 KHDDPNIIPAEHFTLSTMRLPPGQGGALHTHEVEEVFFVLQGRLTVFWEDEGEEHERELGPRDMISVPAGV 111
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
95-182 1.14e-05

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 44.07  E-value: 1.14e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467  95 LFRGIENYRFSLVEMEPTTFFVPHHLDADAVFIVLQGKGviEFVTDktKESFHITKGDVVRIPSGVTNFITNTNQTvPLR 174
Cdd:COG1917  16 LADGEDELEVVRVTFEPGARTPWHSHPGEELIYVLEGEG--EVEVG--GEEYELKPGDVVFIPPGVPHAFRNLGDE-PAV 90


                ....*...
gi 18403467 175 LAQITVPV 182
Cdd:COG1917  91 LLVVFSPG 98
cupin_MJ1618 cd02214
Methanocaldococcus jannaschii MJ1618 and related proteins, cupin domain; This family includes ...
 103-181 1.53e-05

Methanocaldococcus jannaschii MJ1618 and related proteins, cupin domain; This family includes bacterial and archaeal proteins homologous to MJ1618, a Methanocaldococcus jannaschii protein of unknown function with a cupin beta barrel domain. The active site of members of the cupin superfamily is generally located at the center of a conserved barrel and usually includes a metal ion.


Pssm-ID: 380344 [Multi-domain]  Cd Length: 100  Bit Score: 43.66  E-value: 1.53e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467 103 RFSL--VEMEPTTFFVPHHL-DADAVFIVLQGKGVIEfvTDKtkESFHITKGDVVRIPSGVTNFITNTNQTvPLRLAQIT 179
Cdd:cd02214  18 RYSLahARVPPGESTLPHRLkGSEEVYYILEGEGTME--IDG--EPREVGPGDAVLIPPGAVQRIENTGEE-DLVFLCIC 92


                ..
gi 18403467 180 VP 181
Cdd:cd02214  93 SP 94
cupin_RmlC-like cd02208
RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP ...
 104-170 1.67e-05

RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP (deoxythymidine diphosphates)-4-dehydrorhamnose 3,5-epimerase)-like cupins. RmlC is a dTDP-sugar isomerase involved in the synthesis of L-rhamnose, a saccharide required for the virulence of some pathogenic bacteria. Cupins are a functionally diverse superfamily originally discovered based on the highly conserved motif found in germin and germin-like proteins. This conserved motif forms a beta-barrel fold found in all of the cupins, giving rise to the name cupin ('cupa' is the Latin term for small barrel). The active site of members of this superfamily is generally located at the center of a conserved barrel and usually includes a metal ion. The different functional classes in this superfamily include single domain bacterial isomerases and epimerases involved in the modification of cell wall carbohydrates, two domain bicupins such as the desiccation-tolerant seed storage globulins, and multidomain nuclear transcription factors involved in legume root nodulation.


Pssm-ID: 380338 [Multi-domain]  Cd Length: 73  Bit Score: 42.86  E-value: 1.67e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18403467 104 FSLVEMEPTTFFVPH-HLDADAVFIVLQGKGVIEFVTDKTkesFHITKGDVVRIPSGVTNFITNTNQT 170
Cdd:cd02208   1 ISVVTLPPGTSSPPHwHPEQDEIFYVLSGEGELTLDDGET---VELKAGDIVLIPPGVPHSFVNTSDE 65
cupin_DddK cd06988
Dimethylsulfoniopropionate lyase DddK and related proteins, cupin domain; This family includes ...
 117-168 1.90e-05

Dimethylsulfoniopropionate lyase DddK and related proteins, cupin domain; This family includes mostly bacterial proteins homologous to dimethylsulfoniopropionate lyase DddK from marine bacterium Pelagibacter. DddK cleaves dimethylsulfoniopropionate (DMSP), the organic osmolyte and antioxidant produced in marine environments, and yields acrylate and the climate-active gas dimethyl sulfide (DMS). DddK contains a double-stranded beta-helical motif which utilizes various divalent metal ions as cofactors for catalytic activity; however, nickel, an abundant metal ion in marine environments, confers the highest DMSP lyase activity. Also included in this family is Plu4264, a Photorhabdus luminescens manganese-containing cupin shown to have similar metal binding site to TM1287 decarboxylase, but two very different substrate binding pockets. The Plu4264 binding pocket shows a cavity and substrate entry point more than twice as large as and more hydrophobic than TM1287, suggesting that Plu4264 accepts a substrate that is significantly larger than that of TM1287, a putative oxalate decarboxylase. Thus, the function of Plu4264 could be similar to that of TM1287 but with a larger, less charged substrate. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380393 [Multi-domain]  Cd Length: 76  Bit Score: 42.61  E-value: 1.90e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 18403467 117 PHHLDADAVFIVLQGKGVIEfVTDKTKEsfhITKGDVVRIPSGVTNFITNTN 168
Cdd:cd06988  17 PHSHHEYEIFIVISGKGIVV-VDGEREP---VKAGDVVYIPPGTEHYVKNDG 64
cupin_yp_001338853-like cd07008
Klebsiella pneumoniae yp_001338853.1 and related proteins, cupin domain; This family includes ...
 109-179 9.74e-04

Klebsiella pneumoniae yp_001338853.1 and related proteins, cupin domain; This family includes bacterial proteins homologous to Klebsiella pneumoniae yp_001338853.1, an uncharacterized conserved protein with double-stranded beta-helix domain. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380411 [Multi-domain]  Cd Length: 101  Bit Score: 38.39  E-value: 9.74e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18403467 109 MEPTTFFVPH-HLDADAVFIVLQGKGviEFVTDkTKESFHITKGDVVRIPSGVTNFITNTNQtVPLRLAQIT 179
Cdd:cd07008  34 VKPGQEIAAHiHPHGQDTWIVLSGEG--EYLLG-DGQTVPIKAGDIVIAPAGQVHGARNTGD-EPLVFVSVV 101
PLN00212 PLN00212
glutelin; Provisional
 109-238 1.60e-03

glutelin; Provisional


Pssm-ID: 215106 [Multi-domain]  Cd Length: 493  Bit Score: 40.95  E-value: 1.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467  109 MEPTTFFVPHHLDADAVFIVLQGKGVI----------------EFVTDKTKES------------FHitKGDVVRIPSGV 160
Cdd:PLN00212  87 IEPQGLLLPRYSNTPGLVYIIQGRGSMgltfpgcpatyqqqfqQFLTEGQSQSqkfrdehqkihqFR--QGDVVALPAGV 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467  161 TNFITNTNQTvPLrLAQITVPVNNPGN-----YKDYFPAAS--QFQQSY------------FNGFTKEVLSTSFNVPEEL 221
Cdd:PLN00212 165 AHWFYNDGDA-PV-VALYVYDINNNANqleprQREFLLAGNnnRQQQVYgrsieqhsgqniFSGFSTELLSEALGINAQV 242

                        170
                 ....*....|....*..
gi 18403467  222 LGRLVTRSKEIGQgIIR 238
Cdd:PLN00212 243 AKRLQSQNDQRGE-IIR 258
Cupin_2 pfam07883
Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ( ...
 106-160 2.33e-03

Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).


Pssm-ID: 462300 [Multi-domain]  Cd Length: 71  Bit Score: 36.47  E-value: 2.33e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 18403467   106 LVEMEPTTFFVPH-HLDADAVFIVLQGKGviEFVTDktKESFHITKGDVVRIPSGV 160
Cdd:pfam07883   2 LVTLPPGESSPPHrHPGEDEFFYVLEGEG--ELTVD--GEEVVLKAGDSVYFPAGV 53
EutQ COG4766
Ethanolamine utilization protein EutQ, cupin superfamily (function unknown) [Amino acid ...
 108-183 2.94e-03

Ethanolamine utilization protein EutQ, cupin superfamily (function unknown) [Amino acid transport and metabolism];


Pssm-ID: 443798  Cd Length: 123  Bit Score: 37.66  E-value: 2.94e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18403467 108 EMEPTTFfvPHHLDADAVFIVLqgKGVIEFVTDKtkESFHITKGDVVRIPSGVTNFITNTNQTvplRLAQITVPVN 183
Cdd:COG4766  55 RLEKTTF--PWTLTYDEVDYVL--EGTLTIEIDG--ETVTAGPGDVIYIPKGSSITFSTPEKA---RFFYVTYPAN 121
cupin_OxDC-like cd20306
Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and ...
 61-220 4.88e-03

Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and eukaryotic cupin domains of proteins homologous to oxalate decarboxylase (OxDC; EC 4.1.1.2) such as MSMEG_2254, a putative OxDC from Mycobacterium smegmatis. OxDC is a manganese-dependent bicupin that catalyzes the conversion of oxalate to formate and carbon dioxide, utilizing dioxygen as a cofactor. It is evolutionarily related to oxalate oxidase (OxOx or germin; EC 1.2.3.4) which, in contrast, converts oxalate and dioxygen to carbon dioxide and hydrogen peroxide. OxDC is classified as a bicupin because it contains two cupin folds with each domain containing one manganese binding site, with four manganese binding residues (three histidines and one glutamate) conserved as well as a number of hydrophobic residues.


Pssm-ID: 380440 [Multi-domain]  Cd Length: 151  Bit Score: 37.57  E-value: 4.88e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467  61 NHPYHFRKRSFSdwFQSKEGFVRVLpkFTKHAPALfrgiENYRFSLVEMEPTTFFVPH-HLDADAVFIVLQGKGVIEFV- 138
Cdd:cd20306   1 PHLFSLEDSNPF--FESEGGSIRQA--TADQLPVL----KGLSIYRLRLSPGGIREPHwHPNANELGYVISGEARVSILd 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403467 139 TDKTKESFHITKGDVVRIPSGVTNFITNTNQTvPLRLAQItvpVNNPgnykdyFPAASQFQQSyFNGFTKEVLSTSFNVP 218
Cdd:cd20306  73 PTGSLDTFTVKPGQVVFIPQGWLHWIENVGDE-EAHLLIF---FNHE------TPEDIGLSDS-LRATPPEVLGNTYGVD 141


                ..
gi 18403467 219 EE 220
Cdd:cd20306 142 AF 143
cupin_Bh2720-like cd02223
Bacillus halodurans Bh2720 and related proteins, cupin domain; This family includes bacterial, ...
 119-187 6.71e-03

Bacillus halodurans Bh2720 and related proteins, cupin domain; This family includes bacterial, archaeal, and eukaryotic proteins similar to Bh2720, a Bacillus halodurans protein of unknown function with a cupin beta-barrel fold.


Pssm-ID: 380352 [Multi-domain]  Cd Length: 98  Bit Score: 35.98  E-value: 6.71e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18403467 119 HLDADAVFIVLQGKGVIeFVTDKTKEsfhITKGDVVRIPSGVTNFITNTNQtVPLRLAQITVPVNNPGN 187
Cdd:cd02223  29 HDDVDQFLRIEEGEGKA-IMGGFESE---VKDGDAIIVPAGTWHNVINTGN-EPLKLYTIYAPPEHPDG 92
cupin_YdbB-like cd02226
Bacillus subtilis YdbB and related proteins, cupin domain; This family includes bacterial ...
 115-160 7.17e-03

Bacillus subtilis YdbB and related proteins, cupin domain; This family includes bacterial proteins homologous to YdbB, a Bacillus subtilis protein of unknown function. It also includes protein Nmb1881 From Neisseria meningitidis, also of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380355 [Multi-domain]  Cd Length: 94  Bit Score: 35.88  E-value: 7.17e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 18403467 115 FVPH-HLDADAVFIVLQGKGVIEFvtdkTKESFHITKGDVVRIPSGV 160
Cdd:cd02226  35 FVWHkHDDEDELFLVLEGELTIDF----RDRDVTLGPGEFFVVPKGV 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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