|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02762 |
PLN02762 |
pyruvate kinase complex alpha subunit |
93-596 |
0e+00 |
|
pyruvate kinase complex alpha subunit
Pssm-ID: 215407 [Multi-domain] Cd Length: 509 Bit Score: 1071.29 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 93 TDTSGIEVDTVTEAELKENGFRSTRRTKLICTIGPATCGFEQLEALAVGGMNVARLNMCHGTRDWHRGVIRSVRRLNEEK 172
Cdd:PLN02762 1 SDSSGIDVDVVTEAELRENGFRSTRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 173 GFAVAIMMDTEGSEIHMGDLGGEASAKAEDGEVWTFTVRAFDSSRPERTISVSYDGFAEDVRVGDELLVDGGMVRFEVIE 252
Cdd:PLN02762 81 GFAVAVMMDTEGSEIHMGDLGGASSAKAEDGEEWTFTVRKFDGSRPEFTIQVNYDGFAEDVKVGDELVVDGGMVRFEVIE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 253 KIGPDVKCLCTDPGLLLPRANLTFWRDGSLVRERNAMLPTISSKDWLDIDFGIAEGVDFIAVSFVKSAEVINHLKSYLAA 332
Cdd:PLN02762 161 KIGPDVKCKCTDPGLLLPRANLTFWRDGSLVRERNAMLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 333 RSRGGEIGVIAKIESIDSLTNLEEIILASDGAMVARGDLGAQIPLEQVPAAQQRIVQVCRALNKPVIVASQLLESMIEYP 412
Cdd:PLN02762 241 RSRDSDIGVIAKIESLDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 413 TPTRAEVADVSEAVRQRSDALMLSGESAMGQFPDKALTVLRTVSLRIERWWREEKRHESVPLQAIGSSFSDKISEEICNS 492
Cdd:PLN02762 321 TPTRAEVADVSEAVRQRADALMLSGESAMGLYPEKALSVLRSVSLRMELWSREEKRHEALELPQLSSSLSDRISEEICNS 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 493 AAKMANNLGVDAVFVYTTSGHMASLVSRCRPDCPIFAFTTTTSVRRRLNLQWGLIPFRLSFSDDMESNLNKTFSLLKSRG 572
Cdd:PLN02762 401 AAKMANNLGVDAIFVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLDFSDDMESNLNKTFSLLKARG 480
|
490 500
....*....|....*....|....*....
gi 18403597 573 MIKSGDLVIAVSD-----MLQSIQVMNVP 596
Cdd:PLN02762 481 MIKSGDLVIAVSDltpssMLQSIQVRNVP 509
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
117-586 |
1.10e-174 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 503.41 E-value: 1.10e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 117 RRTKLICTIGPATCGFEQLEALAVGGMNVARLNMCHGTRDWHRGVIRSVRRLNEEKGFAVAIMMDTEGSEIHMGDLGGEa 196
Cdd:COG0469 3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEG- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 197 SAKAEDGEVWTFTVRAFDSSrpERTISVSYDGFAEDVRVGDELLVDGGMVRFEVIEKIGPDVKCLCTDPGLL-------L 269
Cdd:COG0469 82 PVELKKGDTFTLTTDDVEGD--AERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLssrkgvnL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 270 PRANLTfwrdgslvrernamLPTISSKDWLDIDFGIAEGVDFIAVSFVKSAEVINHLKSYLaaRSRGGEIGVIAKIESID 349
Cdd:COG0469 160 PGVGLS--------------LPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELL--EEAGGRAPIIAKIEKPE 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 350 SLTNLEEIILASDGAMVARGDLGAQIPLEQVPAAQQRIVQVCRALNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQR 429
Cdd:COG0469 224 AVENLDEIIEASDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDG 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 430 SDALMLSGESAMGQFPDKALTVLRTVSLRIERWwreekRHESVPLQAIGSSFSDKISEEICNSAAKMANNLGVDAVFVYT 509
Cdd:COG0469 304 TDAVMLSGETAVGKYPVEAVETMARIAEEAEKS-----LDYRRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFT 378
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18403597 510 TSGHMASLVSRCRPDCPIFAFTTTTSVRRRLNLQWGLIPFRLSFSDDMESNLNKTFSLLKSRGMIKSGDLVIAVSDM 586
Cdd:COG0469 379 ESGSTARRISRYRPKVPILALTPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGV 455
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
117-584 |
4.73e-143 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 422.84 E-value: 4.73e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 117 RRTKLICTIGPATCGFEQLEALAVGGMNVARLNMCHGTRDWHRGVIRSVRRLNEEKGFAVAIMMDTEGSEIHMGDLGGEA 196
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 197 sAKAEDGEVWTFTVRAFDSSRPERTISVSYDGFAEDVRVGDELLVDGGMVRFEVIEKIGPDVKC-------LCTDPGLLL 269
Cdd:TIGR01064 81 -VKLKKGDKVIITTDDIKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICevlnggtLKSKKGVNL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 270 PRANLTfwrdgslvrernamLPTISSKDWLDIDFGIAEGVDFIAVSFVKSAEVINHLKSYLAARSRGGeIGVIAKIESID 349
Cdd:TIGR01064 160 PGADVD--------------LPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKD-VKIIAKIENQE 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 350 SLTNLEEIILASDGAMVARGDLGAQIPLEQVPAAQQRIVQVCRALNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQR 429
Cdd:TIGR01064 225 GVDNIDEIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDG 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 430 SDALMLSGESAMGQFPDKALTVLRTVSLRIerwwrEEKRH--ESVPLQAIGSSFSDKISEEICNSAAKMANNLGVDAVFV 507
Cdd:TIGR01064 305 TDAVMLSGETAKGKYPVEAVQMMAKIAKEA-----EKALAylTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVV 379
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18403597 508 YTTSGHMASLVSRCRPDCPIFAFTTTTSVRRRLNLQWGLIPFRL-SFSDDMESNLNKTFSLLKSRGMIKSGDLVIAVS 584
Cdd:TIGR01064 380 LTESGRTARLLSKYRPNAPIIAVTPNERVARQLALYWGVFPFLVdEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQ 457
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
117-584 |
1.75e-129 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 388.21 E-value: 1.75e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 117 RRTKLICTIGPATCGFEQLEALAVGGMNVARLNMCHGTRDWHRGVIRSVRRLNEEKGFAVAIMMDTEGSEIHMGDLGGEA 196
Cdd:cd00288 2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGGK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 197 SAKAEDGEVWTFTVRAFDSSRPERTISVSYDGFAEDVRVGDELLVDGGMVRFEVIEKIGPD-VKCLCTDPGLLLPR--AN 273
Cdd:cd00288 82 DISLKAGDKFLVTTDPAAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGGVLGSRkgVN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 274 LTfwrdGSLVRernamLPTISSKDWLDIDFGIAEGVDFIAVSFVKSAEVINHLKSylAARSRGGEIGVIAKIESIDSLTN 353
Cdd:cd00288 162 LP----GTDVD-----LPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIRE--VLGEKGKDIKIIAKIENQEGVNN 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 354 LEEIILASDGAMVARGDLGAQIPLEQVPAAQQRIVQVCRALNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRSDAL 433
Cdd:cd00288 231 FDEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCV 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 434 MLSGESAMGQFPDKALTVLRTVSLRIERWWREEKR-HESVPLQAIGSSfsdkISEEICNSAAKMANNLGVDAVFVYTTSG 512
Cdd:cd00288 311 MLSGETAKGKYPVEAVKAMARICLEAEKALSHRVLfNEMRRLTPRPTS----TTEAVAMSAVRAAFELGAKAIVVLTTSG 386
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18403597 513 HMASLVSRCRPDCPIFAFTTTTSVRRRLNLQWGLIPF-----RLSFSDDMESNLNKTFSLLKSRGMIKSGDLVIAVS 584
Cdd:cd00288 387 RTARLVSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVlfeepKPGWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQ 463
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
117-460 |
4.18e-99 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 305.45 E-value: 4.18e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 117 RRTKLICTIGPATCGFEQLEALAVGGMNVARLNMCHGTRDWHRGVIRSVRRLNEEKGFAVAIMMDTEGSEIHMGDL-GGE 195
Cdd:pfam00224 2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTkDGK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 196 ASAKAEDGEVWTFTVRA-FDSSRPERTISVSYDGFAEDVRVGDELLVDGGMVRFEVIEKIGP-DVKCLCTDPGLLLPRAN 273
Cdd:pfam00224 82 KDIELKAGDEMIVSTDAkYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDkTLVVEVLNGGVIGSRKG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 274 LTFwrDGSLVRernamLPTISSKDWLDIDFGIAEGVDFIAVSFVKSAEVINHLKSYLAARsrGGEIGVIAKIESIDSLTN 353
Cdd:pfam00224 162 VNL--PGTDVD-----LPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEA--GKNIQIIAKIENQEGVNN 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 354 LEEIILASDGAMVARGDLGAQIPLEQVPAAQQRIVQVCRALNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRSDAL 433
Cdd:pfam00224 233 FDEILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCV 312
|
330 340
....*....|....*....|....*..
gi 18403597 434 MLSGESAMGQFPDKALTVLRTVSLRIE 460
Cdd:pfam00224 313 MLSGETAKGNYPVEAVRMMHEICLEAE 339
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02762 |
PLN02762 |
pyruvate kinase complex alpha subunit |
93-596 |
0e+00 |
|
pyruvate kinase complex alpha subunit
Pssm-ID: 215407 [Multi-domain] Cd Length: 509 Bit Score: 1071.29 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 93 TDTSGIEVDTVTEAELKENGFRSTRRTKLICTIGPATCGFEQLEALAVGGMNVARLNMCHGTRDWHRGVIRSVRRLNEEK 172
Cdd:PLN02762 1 SDSSGIDVDVVTEAELRENGFRSTRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 173 GFAVAIMMDTEGSEIHMGDLGGEASAKAEDGEVWTFTVRAFDSSRPERTISVSYDGFAEDVRVGDELLVDGGMVRFEVIE 252
Cdd:PLN02762 81 GFAVAVMMDTEGSEIHMGDLGGASSAKAEDGEEWTFTVRKFDGSRPEFTIQVNYDGFAEDVKVGDELVVDGGMVRFEVIE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 253 KIGPDVKCLCTDPGLLLPRANLTFWRDGSLVRERNAMLPTISSKDWLDIDFGIAEGVDFIAVSFVKSAEVINHLKSYLAA 332
Cdd:PLN02762 161 KIGPDVKCKCTDPGLLLPRANLTFWRDGSLVRERNAMLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 333 RSRGGEIGVIAKIESIDSLTNLEEIILASDGAMVARGDLGAQIPLEQVPAAQQRIVQVCRALNKPVIVASQLLESMIEYP 412
Cdd:PLN02762 241 RSRDSDIGVIAKIESLDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 413 TPTRAEVADVSEAVRQRSDALMLSGESAMGQFPDKALTVLRTVSLRIERWWREEKRHESVPLQAIGSSFSDKISEEICNS 492
Cdd:PLN02762 321 TPTRAEVADVSEAVRQRADALMLSGESAMGLYPEKALSVLRSVSLRMELWSREEKRHEALELPQLSSSLSDRISEEICNS 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 493 AAKMANNLGVDAVFVYTTSGHMASLVSRCRPDCPIFAFTTTTSVRRRLNLQWGLIPFRLSFSDDMESNLNKTFSLLKSRG 572
Cdd:PLN02762 401 AAKMANNLGVDAIFVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLDFSDDMESNLNKTFSLLKARG 480
|
490 500
....*....|....*....|....*....
gi 18403597 573 MIKSGDLVIAVSD-----MLQSIQVMNVP 596
Cdd:PLN02762 481 MIKSGDLVIAVSDltpssMLQSIQVRNVP 509
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
117-586 |
1.10e-174 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 503.41 E-value: 1.10e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 117 RRTKLICTIGPATCGFEQLEALAVGGMNVARLNMCHGTRDWHRGVIRSVRRLNEEKGFAVAIMMDTEGSEIHMGDLGGEa 196
Cdd:COG0469 3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEG- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 197 SAKAEDGEVWTFTVRAFDSSrpERTISVSYDGFAEDVRVGDELLVDGGMVRFEVIEKIGPDVKCLCTDPGLL-------L 269
Cdd:COG0469 82 PVELKKGDTFTLTTDDVEGD--AERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLssrkgvnL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 270 PRANLTfwrdgslvrernamLPTISSKDWLDIDFGIAEGVDFIAVSFVKSAEVINHLKSYLaaRSRGGEIGVIAKIESID 349
Cdd:COG0469 160 PGVGLS--------------LPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELL--EEAGGRAPIIAKIEKPE 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 350 SLTNLEEIILASDGAMVARGDLGAQIPLEQVPAAQQRIVQVCRALNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQR 429
Cdd:COG0469 224 AVENLDEIIEASDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDG 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 430 SDALMLSGESAMGQFPDKALTVLRTVSLRIERWwreekRHESVPLQAIGSSFSDKISEEICNSAAKMANNLGVDAVFVYT 509
Cdd:COG0469 304 TDAVMLSGETAVGKYPVEAVETMARIAEEAEKS-----LDYRRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFT 378
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18403597 510 TSGHMASLVSRCRPDCPIFAFTTTTSVRRRLNLQWGLIPFRLSFSDDMESNLNKTFSLLKSRGMIKSGDLVIAVSDM 586
Cdd:COG0469 379 ESGSTARRISRYRPKVPILALTPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGV 455
|
|
| PLN02623 |
PLN02623 |
pyruvate kinase |
115-590 |
3.11e-151 |
|
pyruvate kinase
Pssm-ID: 215334 [Multi-domain] Cd Length: 581 Bit Score: 447.84 E-value: 3.11e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 115 STRRTKLICTIGPATCGFEQLEALAVGGMNVARLNMCHGTRDWHRGVIRSVRRLNEE-KGFAVAIMMDTEGSEIHMGDLg 193
Cdd:PLN02623 108 VRRKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYNAQsKDNVIAIMLDTKGPEVRSGDL- 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 194 gEASAKAEDGEVWTFTVRAFDSSrpERTISVSYDGFAEDVRVGDELLVDGGMVRFEVIEKIGPDVKCLCTDPGLLLPRAN 273
Cdd:PLN02623 187 -PQPIMLEEGQEFTFTIKRGVST--EDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKCEVVDGGELKSRRH 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 274 LTfwrdgslVRERNAMLPTISSKDWLDIDFGIAEGVDFIAVSFVKSAEVINHLKSYLaaRSRGGEIGVIAKIESIDSLTN 353
Cdd:PLN02623 264 LN-------VRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYL--KSCNADIHVIVKIESADSIPN 334
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 354 LEEIILASDGAMVARGDLGAQIPLEQVPAAQQRIVQVCRALNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRSDAL 433
Cdd:PLN02623 335 LHSIITASDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAV 414
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 434 MLSGESAMGQFPDKALTVLRTVSLRIERWWREEkrhESVPlqAIGSSFSDKISEEICNSAAKMANNLGVdAVFVYTTSGH 513
Cdd:PLN02623 415 MLSGETAHGKFPLKAVKVMHTVALRTEATLPEG---TTPP--NLGQAFKNHMSEMFAFHATMMANTLGT-SIIVFTRTGF 488
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18403597 514 MASLVSRCRPDCPIFAFTTTTSVRRRLNLQWGLIPFRLSFSDDMESNLNKTFSLLKSRGMIKSGDLVIAVSDMLQSI 590
Cdd:PLN02623 489 MAILLSHYRPSGTIFAFTNEKRIQQRLALYQGVCPIYMQFSDDAEETFARALSLLLNKGMVKEGEEVALVQSGRQPI 565
|
|
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
117-584 |
7.59e-145 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 426.88 E-value: 7.59e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 117 RRTKLICTIGPATCGFEQLEALAVGGMNVARLNMCHGTRDWHRGVIRSVRRLNEEKGFAVAIMMDTEGSEIHMGdlggea 196
Cdd:PRK05826 4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVG------ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 197 saKAEDGEVW-------TFTVRAFDSSRPERtISVSYDGFAEDVRVGDELLVDGGMVRFEVIEKIGPDVKCLCTDPGLL- 268
Cdd:PRK05826 78 --KFKEGKITlktgdkfTLDTDQKEEGDKER-VGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLs 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 269 ------LPRANLTfwrdgslvrernamLPTISSKDWLDIDFGIAEGVDFIAVSFVKSAEVINHLKSYLAARSrGGEIGVI 342
Cdd:PRK05826 155 nnkginIPGGGLS--------------LPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAG-CPHAKII 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 343 AKIESIDSLTNLEEIILASDGAMVARGDLGAQIPLEQVPAAQQRIVQVCRALNKPVIVASQLLESMIEYPTPTRAEVADV 422
Cdd:PRK05826 220 AKIERAEAVDNIDEIIEASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDV 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 423 SEAVRQRSDALMLSGESAMGQFPDKALTVLRTVSLRIERWwreekRHESVPLQAIGSSFSDkISEEICNSAAKMANNL-G 501
Cdd:PRK05826 300 ANAVLDGTDAVMLSGETAAGKYPVEAVEAMARICKGAEKE-----FSINLSKHRLDRQFDR-IDEAIAMSAMYAANHLkG 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 502 VDAVFVYTTSGHMASLVSRCRPDCPIFAFTTTTSVRRRLNLQWGLIPFRLSFSDDMESNLNKTFSLLKSRGMIKSGDLVI 581
Cdd:PRK05826 374 VKAIVALTESGRTARLISRFRPGAPIFAVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVV 453
|
...
gi 18403597 582 AVS 584
Cdd:PRK05826 454 VTS 456
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
117-584 |
4.73e-143 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 422.84 E-value: 4.73e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 117 RRTKLICTIGPATCGFEQLEALAVGGMNVARLNMCHGTRDWHRGVIRSVRRLNEEKGFAVAIMMDTEGSEIHMGDLGGEA 196
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 197 sAKAEDGEVWTFTVRAFDSSRPERTISVSYDGFAEDVRVGDELLVDGGMVRFEVIEKIGPDVKC-------LCTDPGLLL 269
Cdd:TIGR01064 81 -VKLKKGDKVIITTDDIKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICevlnggtLKSKKGVNL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 270 PRANLTfwrdgslvrernamLPTISSKDWLDIDFGIAEGVDFIAVSFVKSAEVINHLKSYLAARSRGGeIGVIAKIESID 349
Cdd:TIGR01064 160 PGADVD--------------LPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKD-VKIIAKIENQE 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 350 SLTNLEEIILASDGAMVARGDLGAQIPLEQVPAAQQRIVQVCRALNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQR 429
Cdd:TIGR01064 225 GVDNIDEIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDG 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 430 SDALMLSGESAMGQFPDKALTVLRTVSLRIerwwrEEKRH--ESVPLQAIGSSFSDKISEEICNSAAKMANNLGVDAVFV 507
Cdd:TIGR01064 305 TDAVMLSGETAKGKYPVEAVQMMAKIAKEA-----EKALAylTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVV 379
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18403597 508 YTTSGHMASLVSRCRPDCPIFAFTTTTSVRRRLNLQWGLIPFRL-SFSDDMESNLNKTFSLLKSRGMIKSGDLVIAVS 584
Cdd:TIGR01064 380 LTESGRTARLLSKYRPNAPIIAVTPNERVARQLALYWGVFPFLVdEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQ 457
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
117-584 |
1.75e-129 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 388.21 E-value: 1.75e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 117 RRTKLICTIGPATCGFEQLEALAVGGMNVARLNMCHGTRDWHRGVIRSVRRLNEEKGFAVAIMMDTEGSEIHMGDLGGEA 196
Cdd:cd00288 2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGGK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 197 SAKAEDGEVWTFTVRAFDSSRPERTISVSYDGFAEDVRVGDELLVDGGMVRFEVIEKIGPD-VKCLCTDPGLLLPR--AN 273
Cdd:cd00288 82 DISLKAGDKFLVTTDPAAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGGVLGSRkgVN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 274 LTfwrdGSLVRernamLPTISSKDWLDIDFGIAEGVDFIAVSFVKSAEVINHLKSylAARSRGGEIGVIAKIESIDSLTN 353
Cdd:cd00288 162 LP----GTDVD-----LPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIRE--VLGEKGKDIKIIAKIENQEGVNN 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 354 LEEIILASDGAMVARGDLGAQIPLEQVPAAQQRIVQVCRALNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRSDAL 433
Cdd:cd00288 231 FDEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCV 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 434 MLSGESAMGQFPDKALTVLRTVSLRIERWWREEKR-HESVPLQAIGSSfsdkISEEICNSAAKMANNLGVDAVFVYTTSG 512
Cdd:cd00288 311 MLSGETAKGKYPVEAVKAMARICLEAEKALSHRVLfNEMRRLTPRPTS----TTEAVAMSAVRAAFELGAKAIVVLTTSG 386
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18403597 513 HMASLVSRCRPDCPIFAFTTTTSVRRRLNLQWGLIPF-----RLSFSDDMESNLNKTFSLLKSRGMIKSGDLVIAVS 584
Cdd:cd00288 387 RTARLVSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVlfeepKPGWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQ 463
|
|
| PRK06247 |
PRK06247 |
pyruvate kinase; Provisional |
114-583 |
2.54e-112 |
|
pyruvate kinase; Provisional
Pssm-ID: 180487 [Multi-domain] Cd Length: 476 Bit Score: 343.83 E-value: 2.54e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 114 RSTRRTKLICTIGPATCGFEQLEALAVGGMNVARLNMCHGTRDWHRGVIRSVRRLNEEKGFAVAIMMDTEGSEIHMGDLG 193
Cdd:PRK06247 2 KRNRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 194 gEASAKAEDGEVWTFTVRAF--DSSRpertISVSYDGFAEDVRVGDELLVDGGMVRFEVIEKIGPDVKCLCTDPGLL--- 268
Cdd:PRK06247 82 -DGKVQLANGQTFRLDVDDApgDHDR----VSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVsdr 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 269 ----LPRANLTfwrdgslvrernamLPTISSKDWLDIDFGIAEGVDFIAVSFVKSAEVINhlksyLAARSRGGEIGVIAK 344
Cdd:PRK06247 157 kgvsLPGTVLS--------------VSALTEKDRADLEFALELGVDWVALSFVQRPEDVE-----EVRKIIGGRVPVMAK 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 345 IESIDSLTNLEEIILASDGAMVARGDLGAQIPLEQVPAAQQRIVQVCRALNKPVIVASQLLESMIEYPTPTRAEVADVSE 424
Cdd:PRK06247 218 IEKPQAIDRLEAIVEASDAIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVAT 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 425 AVRQRSDALMLSGESAMGQFPdkaLTVLRTVSlRIERWWREEKRHES---VPLQAIGSSFSDKISEeicnSAAKMANNLG 501
Cdd:PRK06247 298 AVLDGADAVMLSAETASGKYP---VEAVRTMA-RIIRQVERDPTYPPlihAQRPQPEATKRDAISY----AARDIAERLD 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 502 VDAVFVYTTSGHMASLVSRCRPDCPIFAFTTTTSVRRRLNLQWGLIPF---RLSFSDDMESNLNKTfslLKSRGMIKSGD 578
Cdd:PRK06247 370 LAALVAYTSSGDTALRAARERPPLPILALTPNPETARRLALTWGVHCVvvdDARDTDDMVRRADRI---ALAEGFYKRGD 446
|
....*
gi 18403597 579 LVIAV 583
Cdd:PRK06247 447 RVVIV 451
|
|
| PRK09206 |
PRK09206 |
pyruvate kinase PykF; |
117-587 |
1.78e-107 |
|
pyruvate kinase PykF;
Pssm-ID: 181699 [Multi-domain] Cd Length: 470 Bit Score: 331.25 E-value: 1.78e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 117 RRTKLICTIGPATCGFEQLEALAVGGMNVARLNMCHGTRDWHRGVIRSVRRLNEEKGFAVAIMMDTEGSEIHMGDLGGEA 196
Cdd:PRK09206 2 KKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKLEGGN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 197 SAKAEDGEVWTFTVrafDSS---RPERtISVSYDGFAEDVRVGDELLVDGGMVRFEVIEKIGPDVKCLCTDPGLL----- 268
Cdd:PRK09206 82 DVSLKAGQTFTFTT---DKSvvgNKER-VAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLgenkg 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 269 --LPRANLTfwrdgslvrernamLPTISSKDWLDIDFGIAEGVDFIAVSFVKSAEVINHLKSYLAARsrGGE-IGVIAKI 345
Cdd:PRK09206 158 vnLPGVSIA--------------LPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAH--GGEnIQIISKI 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 346 ESIDSLTNLEEIILASDGAMVARGDLGAQIPLEQVPAAQQRIVQVCRALNKPVIVASQLLESMIEYPTPTRAEVADVSEA 425
Cdd:PRK09206 222 ENQEGLNNFDEILEASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANA 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 426 VRQRSDALMLSGESAMGQFPDKALTVLRTVSLRIERWW--REEKRHESVPLqaigssfsdKISEEICNSAAKMANNLGVD 503
Cdd:PRK09206 302 ILDGTDAVMLSGESAKGKYPLEAVSIMATICERTDRVMnsRLESNNDNRKL---------RITEAVCRGAVETAEKLDAP 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 504 AVFVYTTSGHMASLVSRCRPDCPIFAFTTTTSVRRRLNLQWGLIPFRLSFSDDMESNLNKTFSLLKSRGMIKSGDLVIAV 583
Cdd:PRK09206 373 LIVVATQGGKSARSVRKYFPDATILALTTNEKTARQLVLSKGVVPQLVKEIASTDDFYRLGKELALQSGLAQKGDVVVMV 452
|
....
gi 18403597 584 SDML 587
Cdd:PRK09206 453 SGAL 456
|
|
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
115-581 |
7.12e-106 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 331.12 E-value: 7.12e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 115 STRRTKLICTIGPATCGFEQLEALAVGGMNVARLNMCHGTRDWHRGVIRSVRRLNEEKGFAVAIMMDTEGSEIHMGDLGg 194
Cdd:PRK06354 6 LMRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFE- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 195 EASAKAEDGEVWTFTVRAFDSSrPERtISVSYDGFAEDVRVGDELLVDGGMVRFEV--IEKIGPDVKCLCTDPGLLLPRA 272
Cdd:PRK06354 85 DGPIELKTGDEFILTSREVLGT-QEK-FSVTYDGLADEVPVGSRILLDDGLIELEVeeVDKADGELHCKVLVGGVLSNKK 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 273 NLTFwRDGSLvrernaMLPTISSKDWLDIDFGIAEGVDFIAVSFVKSAEVINHLKSyLAARSRGGEIGVIAKIESIDSLT 352
Cdd:PRK06354 163 GVNF-PGVSL------SLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRE-LIEEHNGKHIPIIAKIEKQEAID 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 353 NLEEIILASDGAMVARGDLGAQIPLEQVPAAQQRIVQVCRALNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRSDA 432
Cdd:PRK06354 235 NIDAILELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDA 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 433 LMLSGESAMGQFPDKALTVLRTVSLRIERwwreekrheSVPLQAIGSSFSDK---ISEEICNSAAKMANNLGVDAVFVYT 509
Cdd:PRK06354 315 VMLSNETAAGDYPVEAVQTMATIAVRIEK---------DLPYRDILSKRPEFtttITNAISQAVSHIALQLDAAAIVTLT 385
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18403597 510 TSGHMASLVSRCRPDCPIFAFTTTTSVRRRLNLQWGLIPF---RLSFSDDMesnLNKTFSLLKSRGMIKSGDLVI 581
Cdd:PRK06354 386 KSGATARNVSKYRPKTPILAVTPNESVARRLQLVWGVTPLlvlDAPSTDET---FDAAINVAQESGLLKQGDLVV 457
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
117-460 |
4.18e-99 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 305.45 E-value: 4.18e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 117 RRTKLICTIGPATCGFEQLEALAVGGMNVARLNMCHGTRDWHRGVIRSVRRLNEEKGFAVAIMMDTEGSEIHMGDL-GGE 195
Cdd:pfam00224 2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTkDGK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 196 ASAKAEDGEVWTFTVRA-FDSSRPERTISVSYDGFAEDVRVGDELLVDGGMVRFEVIEKIGP-DVKCLCTDPGLLLPRAN 273
Cdd:pfam00224 82 KDIELKAGDEMIVSTDAkYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDkTLVVEVLNGGVIGSRKG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 274 LTFwrDGSLVRernamLPTISSKDWLDIDFGIAEGVDFIAVSFVKSAEVINHLKSYLAARsrGGEIGVIAKIESIDSLTN 353
Cdd:pfam00224 162 VNL--PGTDVD-----LPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEA--GKNIQIIAKIENQEGVNN 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 354 LEEIILASDGAMVARGDLGAQIPLEQVPAAQQRIVQVCRALNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRSDAL 433
Cdd:pfam00224 233 FDEILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCV 312
|
330 340
....*....|....*....|....*..
gi 18403597 434 MLSGESAMGQFPDKALTVLRTVSLRIE 460
Cdd:pfam00224 313 MLSGETAKGNYPVEAVRMMHEICLEAE 339
|
|
| PTZ00066 |
PTZ00066 |
pyruvate kinase; Provisional |
84-590 |
4.49e-91 |
|
pyruvate kinase; Provisional
Pssm-ID: 173361 [Multi-domain] Cd Length: 513 Bit Score: 290.12 E-value: 4.49e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 84 RSVVATAVTTDTSG----IEVDTVTEaELKENGFRStRRTKLICTIGPATCGFEQLEALAVGGMNVARLNMCHGTRDWHR 159
Cdd:PTZ00066 3 RLASTSSVMGCSLGkatnISLDKILE-PISDNDLRQ-KKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 160 GVIRSVRRLNEEKGFA-VAIMMDTEGSEIHMGDLGGEASAKAEDGEVWTFTVRaFDSSRPERTISVSYDGFAEDVRVGDE 238
Cdd:PTZ00066 81 KTLNNVREAAKARPNAnLGILLDTKGPEIRTGFLKNHKPITLKEGQTLKITTD-YTFLGDETCISCSYKKLPQSVKVGNI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 239 LLVDGGMVRFEVIEkIGPD---VKCLCTdpglllpranltfwrdgSLVRERNAM--------LPTISSKDWLDI-DFGIA 306
Cdd:PTZ00066 160 ILIADGSLSCKVLE-VHDDyiiTKVLNN-----------------ATIGERKNMnlpgvkveLPVIGEKDKNDIlNFAIP 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 307 EGVDFIAVSFVKSAEVINHLKSYLAARSRggEIGVIAKIESIDSLTNLEEIILASDGAMVARGDLGAQIPLEQVPAAQQR 386
Cdd:PTZ00066 222 MGCDFIALSFVQSADDVRLCRQLLGERGR--HIKIIPKIENIEGLINFDEILAESDGIMVARGDLGMEIPPEKVFLAQKM 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 387 IVQVCRALNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRSDALMLSGESAMGQFPDKALTVLRTVSLRIERWwree 466
Cdd:PTZ00066 300 MISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETANGKFPVEAVNIMAKICFEAETC---- 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 467 kRHESVPLQAIGSSFSDKIS--EEICNSAAKMANNLGVDAVFVYTTSGHMASLVSRCRPDCPIFAFTTTTSVRRRLNLQW 544
Cdd:PTZ00066 376 -IDYRVLYHAIHLAVPTPVSvqEAVARSAVETAEDINAKLIIALTETGNTARLISKYRPSCTILALSASPSVVKSLSVAR 454
|
490 500 510 520
....*....|....*....|....*....|....*....|....*.
gi 18403597 545 GLIPFRLSFSDDMESNLNKTFSLLKSRGMIKSGDLVIAVSDMLQSI 590
Cdd:PTZ00066 455 GVTTYVVNSFQGTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEV 500
|
|
| PLN02461 |
PLN02461 |
Probable pyruvate kinase |
110-596 |
8.33e-90 |
|
Probable pyruvate kinase
Pssm-ID: 215255 [Multi-domain] Cd Length: 511 Bit Score: 286.87 E-value: 8.33e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 110 ENGFRSTRRTKLICTIGPATCGFEQLEALAVGGMNVARLNMCHGTRDWHRGVIRSVRRLNEEKGFAVAIMMDTEGSEIHM 189
Cdd:PLN02461 14 PADGLRRPKTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRT 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 190 GDL-GGEASAKAEDGEVWTFTvrafDSSRP--ERTISVSYDGFAEDVRVGDELLVDGGMVRFEVIE--KIGPDVKCLCTD 264
Cdd:PLN02461 94 GFLkDGKPVQLKQGQEITITT----DYSIKgdENMIAMSYKKLAVDVKPGSVILCADGTITLTVLScdVEAGTVRCRCEN 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 265 PGLLLPRANLTFwrDGSLVRernamLPTISSKDWLDI-DFGIAEGVDFIAVSFVKSAEVINHLKSYLAARSRggEIGVIA 343
Cdd:PLN02461 170 SAMLGERKNVNL--PGVVVD-----LPTLTEKDKEDIlQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAK--SILLIS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 344 KIESIDSLTNLEEIILASDGAMVARGDLGAQIPLEQVPAAQQRIVQVCRALNKPVIVASQLLESMIEYPTPTRAEVADVS 423
Cdd:PLN02461 241 KVENQEGLDNFDDILAESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 424 EAVRQRSDALMLSGESAMGQFPDKALTVLRTVSLRIERW------WREEKRHESVPLQAIgssfsdkisEEICNSAAKMA 497
Cdd:PLN02461 321 NAVLDGTDCVMLSGETAAGAYPELAVKTMARICREAEASldygalFKEIMRSAPLPMSPL---------ESLASSAVRTA 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 498 NNLGVDAVFVYTTSGHMASLVSRCRPDCPIF----------AFTTTTSVR---RRLNLQWGLIPF------RLSFSDDME 558
Cdd:PLN02461 392 NKVKASLIVVLTRGGTTARLVAKYRPAVPILsvvvpeittdSFDWSCSDEapaRHSLIYRGLIPVlaegsaKATDSESTE 471
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 18403597 559 SNLNKTFSLLKSRGMIKSGDLVIAVSDMLQS--IQVMNVP 596
Cdd:PLN02461 472 EILEAAIEHAKKKGLCKPGDSVVALHRIGGAsvIKILTVK 511
|
|
| PTZ00300 |
PTZ00300 |
pyruvate kinase; Provisional |
143-583 |
5.33e-83 |
|
pyruvate kinase; Provisional
Pssm-ID: 140321 [Multi-domain] Cd Length: 454 Bit Score: 267.30 E-value: 5.33e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 143 MNVARLNMCHGTRDWHRGVIRSVRRLNEEKGFAVAIMMDTEGSEIHMGDLGGEASAKAEDGEVWTFTVRAFDSSRPERTI 222
Cdd:PTZ00300 1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGGEAVMERGATCYVTTDPAFADKGTKDKF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 223 SVSYDGFAEDVRVGDELLVDGGMVRFEVIEKIGPD-VKCLCTDPGLLLPRANLTFwrDGSLVRernamLPTISSKDWLDI 301
Cdd:PTZ00300 81 YIDYQNLSKVVRPGGYIYIDDGILILHVQSHEDEQtLKCTVTNAHTISDRRGVNL--PGCDVD-----LPAVSAKDCADL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 302 DFGIAEGVDFIAVSFVKSAEVINHLKSYLAARsrGGEIGVIAKIESIDSLTNLEEIILASDGAMVARGDLGAQIPLEQVP 381
Cdd:PTZ00300 154 QFGVEQGVDMIFASFIRSAEQVGEVRKALGAK--GGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVV 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 382 AAQQRIVQVCRALNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRSDALMLSGESAMGQFPDKALTVLRTVSLRIER 461
Cdd:PTZ00300 232 VAQKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQS 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 462 WWREEKRHESV-PLQAIGSSfsdkISEEICNSAAKMANNLGVDAVFVYTTSGHMASLVSRCRPDCPIFAFTTTTSVRRRL 540
Cdd:PTZ00300 312 AVNEYVFFNSIkKLQPIPMS----AEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQL 387
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 18403597 541 NLQWGL--IPF---RLSFSDDMESNLNKTFSLLKSRGMIKSGDLVIAV 583
Cdd:PTZ00300 388 NITQGVesVFFdaeRLGHDEGKEQRVAMGVGFAKSKGYVQSGDLMVVV 435
|
|
| PRK06739 |
PRK06739 |
pyruvate kinase; Validated |
122-456 |
6.27e-73 |
|
pyruvate kinase; Validated
Pssm-ID: 180676 [Multi-domain] Cd Length: 352 Bit Score: 237.54 E-value: 6.27e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 122 ICTIGPATCGFEQLEALAVGGMNVARLNMCHGTRDWHRGVIRSVRRLNEekgfAVAIMMDTEGSEIHMGDLGGEaSAKAE 201
Cdd:PRK06739 6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSLDD----SIKILGDVQGPKIRLGEIKGE-QITLQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 202 DGEVWTFTVRAFDSSRPErtISVSYDGFAEDVRVGDELLVDGGMVRFeVIEKIGPD-----VKC---LCTDPGLLLPran 273
Cdd:PRK06739 81 AGDSFILHTQPVTGSSTE--ASVDYEGIANDVKVGSRILMNDGEVEL-IVEKVSTDkietkVKTggnISSHKGVNLP--- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 274 ltfwrdGSLVRernamLPTISSKDWLDIDFGIAEGVDFIAVSFVKSAEVINHLKSYLAARSRGGEiGVIAKIESIDSLTN 353
Cdd:PRK06739 155 ------GAIVR-----LPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSP-NLIAKIETMEAIEN 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 354 LEEIILASDGAMVARGDLGAQIPLEQVPAAQQRIVQVCRALNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRSDAL 433
Cdd:PRK06739 223 FQDICKEADGIMIARGDLGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAV 302
|
330 340
....*....|....*....|...
gi 18403597 434 MLSGESAMGQFPDKALTVLRTVS 456
Cdd:PRK06739 303 MLSAESASGEHPIESVSTLRLVS 325
|
|
| PLN02765 |
PLN02765 |
pyruvate kinase |
119-581 |
8.95e-62 |
|
pyruvate kinase
Pssm-ID: 215409 [Multi-domain] Cd Length: 526 Bit Score: 212.99 E-value: 8.95e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 119 TKLICTIGPATCGFEQLEALAVGGMNVARLNMCHGTRDWH-------RGVIRSVRRLneekgfaVAIMMDTEGSEIHMGD 191
Cdd:PLN02765 30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHqetlenlKIAVKNTKKL-------CAVMLDTVGPELQVIN 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 192 LGGEASAKAEDGEVwTFTVrafDSSRP--ERTISVSYDGFAEDVRVGDELLV--------DGGMVRFEVIEKIGPDVKCL 261
Cdd:PLN02765 103 KTEKPISLKAGNTV-TLTP---DQSKEasSEVLPINFPGLAKAVKPGDTIFVgqylftgsETTSVWLEVDEVKGDDVVCT 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 262 CTDPGLLlprANLTFWRDGSLVRERnamLPTISSKDWLDI-DFGIAEGVDFIAVSFVKSAEVINHLKSYLAARSrGGEIG 340
Cdd:PLN02765 179 VKNSATL---AGSLFTLHVSQVRID---LPTLSEKDKEVIsTWGVPNKIDFLSLSYTRHAEDVREAREFLSSLG-LSQTQ 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 341 VIAKIESIDSLTNLEEIILASDGAMVARGDLGAQIPLEQVPAAQQRIVQVCRALNKPVIVaSQLLESMIEYPTPTRAEVA 420
Cdd:PLN02765 252 IFAKIENVEGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEAT 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 421 DVSEAVRQRSDALMLSGESAMGQFPDKALTVLRTVSLRIERWWREEKRHESVpLQAIGSSFSDkiSEEICNSAAKMANNL 500
Cdd:PLN02765 331 DVANAVLDGADAILLGAETLRGLYPVETISTVGRICAEAEKVFNQDLYFKKT-VKYVGEPMSH--LESIASSAVRAAIKV 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 501 GVDAVFVYTTSGHMASLVSRCRPDCPIFA--------------FTTTTSVRRRLnLQWGLIPF-------RLSFSDDMES 559
Cdd:PLN02765 408 KASVIIVFTSSGRAARLIAKYRPTMPVLSvviprlktnqlkwsFTGAFQARQCL-IVRGLFPMladprhsAESTSATNES 486
|
490 500
....*....|....*....|..
gi 18403597 560 NLNKTFSLLKSRGMIKSGDLVI 581
Cdd:PLN02765 487 VLKVALDHGKAAGVIKSHDRVV 508
|
|
| PRK08187 |
PRK08187 |
pyruvate kinase; Validated |
114-461 |
2.69e-37 |
|
pyruvate kinase; Validated
Pssm-ID: 236178 Cd Length: 493 Bit Score: 144.77 E-value: 2.69e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 114 RSTRRTKLICTI-GPATCGFEQLEALAVGGMNVARLNMCHGTRDWHRGVIRSVRRLNEEKGFAVAIMMDTEGSEIHMGDL 192
Cdd:PRK08187 130 PAARRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRTGAV 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 193 GGEAS-AKAEDGE-VWTFTVRAFDSSRPERT-ISVSYDGFAEDVRVGDELLVDGGMVRfEVIEKIGPDvkclctdpGLLL 269
Cdd:PRK08187 210 AGPLGkTRLYTGDrLALVAQGPPRRIDEEHFqVTCTLPEILARLAVGARVWIDDGKLG-ARVERVGPG--------GALL 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 270 praNLTFWRD-GSLVRERNAM--------LPTISSKDWLDIDFgIAEGVDFIAVSFVKSAEVINHLKSYLAARSRGGE-- 338
Cdd:PRK08187 281 ---EVTHARPkGLKLKPEKGLnfpdtaldLPALTEKDRADLDF-VARHADLVGYSFVQSPGDVEALQAALAARRPDDWrk 356
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 339 IGVIAKIESIDSLTNLEEIILASDG-----AMVARGDLGAQIPLEQVPAAQQRIVQVCRALNKPVIVASQLLESMIEYPT 413
Cdd:PRK08187 357 LGLVLKIETPRAVANLPELIVQAAGrqpfgVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGL 436
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 18403597 414 PTRAEVADVseAVRQRSDALMLSgesaMGQFPDKALTVLRTVSLRIER 461
Cdd:PRK08187 437 PSRAEMTDA--AMAARAECVMLN----KGPYLVEAVTFLDDLLARMDG 478
|
|
| PK_C |
pfam02887 |
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ... |
487-584 |
9.02e-29 |
|
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.
Pssm-ID: 460738 [Multi-domain] Cd Length: 114 Bit Score: 110.26 E-value: 9.02e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 487 EEICNSAAKMANNLGVDAVFVYTTSGHMASLVSRCRPDCPIFAFTTTTSVRRRLNLQWGLIPFRLSFSDDMESNLNKTFS 566
Cdd:pfam02887 1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTDEMLRRAVK 80
|
90
....*....|....*...
gi 18403597 567 LLKSRGMIKSGDLVIAVS 584
Cdd:pfam02887 81 VAKEAGLVKKGDLVVITA 98
|
|
| PRK14725 |
PRK14725 |
pyruvate kinase; Provisional |
218-461 |
3.15e-28 |
|
pyruvate kinase; Provisional
Pssm-ID: 237804 Cd Length: 608 Bit Score: 119.28 E-value: 3.15e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 218 PERTISVSYDGFAEDVRVGDELLVD----GGMVR------FEV-IEKIGPDVKCLCTDPGLLLPRANLTfwrdgslvrer 286
Cdd:PRK14725 358 PPARISCTLPEAFRAARVGERVWFDdgkiGAVVVkveadeVELrITHARPGGSKLKAGKGINLPDSHLP----------- 426
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 287 namLPTISSKDWLDIDFgIAEGVDFIAVSFVKSAEVINHLKSYLAARsRGGEIGVIAKIESIDSLTNLEEIILA-----S 361
Cdd:PRK14725 427 ---LPALTDKDLEDLAF-VAKHADIVALSFVRSPEDVRLLLDALEKL-GADDLGVVLKIETRRAFENLPRILLEamrhpR 501
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 362 DGAMVARGDLGAQIPLEQVPAAQQRIVQVCRALNKPVIVASQLLESMIEYPTPTRAEVADVseAVRQRSDALMLSgesaM 441
Cdd:PRK14725 502 FGVMIARGDLAVEVGFERLAEVQEEILWLCEAAHVPVIWATQVLESLAKKGLPSRAEITDA--AMALRAECVMLN----K 575
|
250 260
....*....|....*....|
gi 18403597 442 GQFPDKALTVLRTVSLRIER 461
Cdd:PRK14725 576 GPHIVEAVRVLDDILRRMEE 595
|
|
| PykA2 |
COG3848 |
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms]; |
391-581 |
2.01e-23 |
|
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
Pssm-ID: 443058 Cd Length: 321 Bit Score: 101.13 E-value: 2.01e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 391 CRALNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRSDALMLSGESAMGQFPDKALTVLRTVSLRIERwwrEEKRHE 470
Cdd:COG3848 2 CNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEE---DLEYRE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 471 SVPLQAIGSSFSdkISEEICNSAAKMANNLGVDAVFVYTTSGHMASLVSRCRPDCPIFAFTTTTSVRRRLNLQWGLIPFR 550
Cdd:COG3848 79 QRVPRAKESSTT--ITDAISHAVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLL 156
|
170 180 190
....*....|....*....|....*....|.
gi 18403597 551 LSFSDDMESNLNKTFSLLKSRGMIKSGDLVI 581
Cdd:COG3848 157 VEESASTDEMFAVAVALALEAGLVKDGDLVV 187
|
|
| HpcH |
COG3836 |
2-keto-3-deoxy-L-rhamnonate aldolase RhmA [Carbohydrate transport and metabolism]; |
326-398 |
5.48e-05 |
|
2-keto-3-deoxy-L-rhamnonate aldolase RhmA [Carbohydrate transport and metabolism];
Pssm-ID: 443047 [Multi-domain] Cd Length: 237 Bit Score: 44.72 E-value: 5.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 326 LKSYLAARSRggEIGVIAKIESIDSLTNLEEIilAS----DGAMVARGDLGA------QIPLEQVPAAQQRIVQVCRALN 395
Cdd:COG3836 131 VADYLARAND--ETLVIVQIETAEAVENLDEI--AAvpgvDGVFIGPADLSAslghpgQPDHPEVQAAIERVIAAARAAG 206
|
...
gi 18403597 396 KPV 398
Cdd:COG3836 207 KPA 209
|
|
| CitE |
COG2301 |
Citrate lyase beta subunit [Carbohydrate transport and metabolism]; |
293-399 |
5.88e-05 |
|
Citrate lyase beta subunit [Carbohydrate transport and metabolism];
Pssm-ID: 441876 Cd Length: 288 Bit Score: 45.14 E-value: 5.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 293 ISSKDWL-DIDFGIAEGVDFIAVSFVKSAEVINHLKSYLAARSR-GGEIGVIAKIESIDSLTNLEEIILASDG--AMVA- 367
Cdd:COG2301 72 LDTPWGLdDLAALVGAGLDGIVLPKVESAEDVRALAALLTELEAeGGSIPLMALIETARGLLNAAEIAAASPRveALVFg 151
|
90 100 110
....*....|....*....|....*....|....*...
gi 18403597 368 ----RGDLGAQIPLEQVP--AAQQRIVQVCRALNKPVI 399
Cdd:COG2301 152 aedlAADLGARRTRDGDEllYARSRIVLAARAAGLAAI 189
|
|
| HpcH_HpaI |
pfam03328 |
HpcH/HpaI aldolase/citrate lyase family; This family includes 2,4-dihydroxyhept-2-ene-1, ... |
308-393 |
2.74e-03 |
|
HpcH/HpaI aldolase/citrate lyase family; This family includes 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase and 4-hydroxy-2-oxovalerate aldolase.
Pssm-ID: 427247 [Multi-domain] Cd Length: 221 Bit Score: 39.64 E-value: 2.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403597 308 GVDFIAVSFVKSAEVINHLKSYLAARSRG-----GEIGVIAKIESIDSLTNLEEiILASDGAM-VARG--DLGAQIPLEQ 379
Cdd:pfam03328 84 GAQVVLVPKVETAEDARAAVSAIRYPPKGirranGNTCLLAQIESALGVLNADE-IAAVEGVDgIFLGaeDLSADLGTLR 162
|
90 100
....*....|....*....|
gi 18403597 380 VP------AAQQRIVQVCRA 393
Cdd:pfam03328 163 SPggpevlYARERIVTAARA 182
|
|
| |
