|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02782 |
PLN02782 |
Branched-chain amino acid aminotransferase |
13-413 |
0e+00 |
|
Branched-chain amino acid aminotransferase
Pssm-ID: 215418 Cd Length: 403 Bit Score: 824.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 13 NYLLCPSRAFSTRLHSSTRNLSPPSFASIKLQHSSSSVSSN----GGISLTRCNAVSSNSSsTLVTELADIDWDTVGFGL 88
Cdd:PLN02782 1 NYLLCPSRAFSTRLHSSSRRLNFPPPSSLSLRHSNSSVSSNpissKAISLTRCDAVSSSSY-TEVTELADIDWDNLGFGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 89 KPADYMYVMKCNIDGEFSKGELQRFGNIEISPSAGVLNYGQGLFEGLKAYRKKDGNnILLFRPEENAKRMRNGAERMCMP 168
Cdd:PLN02782 80 VPTDYMYIMKCNRDGEFSKGELQRFGNIELSPSAGVLNYGQGLFEGLKAYRKEDGN-ILLFRPEENAIRMRNGAERMCMP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 169 APTVEQFVEAVTETVLANKRWVPPPGKGSLYVRPLLMGTGAVLGLAPAPEYTFIIYVSPVGNYFKEGVAPINLIVENEFH 248
Cdd:PLN02782 159 APTVEQFVEAVKETVLANKRWVPPPGKGSLYIRPLLMGSGAVLGLAPAPEYTFLIYVSPVGNYFKEGVAPINLIVENEFH 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 249 RATPGGTGGVKTIGNYAAVLKAQSIAKAKGYSDVLYLDCIYKRYLEEVSSCNIFIVKDNVISTPEIKGTILPGITRKSMI 328
Cdd:PLN02782 239 RATPGGTGGVKTIGNYAAVLKAQSIAKAKGYSDVLYLDCVHKKYLEEVSSCNIFIVKDNVISTPAIKGTILPGITRKSII 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 329 DVARTQGFQVEERNVTVDELLEADEVFCTGTAVVVSPVGSVTYKGKRVSYGEGTFGTVSKQLYTVLTSLQMGLIEDNMKW 408
Cdd:PLN02782 319 DVARSQGFQVEERNVTVDELLEADEVFCTGTAVVVSPVGSITYKGKRVSYGEGGFGTVSQQLYTVLTSLQMGLIEDNMNW 398
|
....*
gi 18408919 409 TVNLS 413
Cdd:PLN02782 399 TVELS 403
|
|
| BCAT_beta_family |
cd01557 |
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the ... |
117-400 |
4.59e-136 |
|
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two foms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme. The mitochondrial form plays a significant role in skeletal muscle glutamine and alanine synthesis and in interorgan nitrogen metabolism.Members of this subgroup are widely distributed in all three forms of life.
Pssm-ID: 238798 Cd Length: 279 Bit Score: 390.79 E-value: 4.59e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 117 EISPSAGVLNYGQGLFEGLKAYRKKDGNnILLFRPEENAKRMRNGAERMCMPAPTVEQFVEAVTETVLANKRWVPPPGKG 196
Cdd:cd01557 1 SLHPATHALHYGQAVFEGLKAYRTPDGK-IVLFRPDENAERLNRSARRLGLPPFSVEEFIDAIKELVKLDADWVPYGGGA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 197 SLYVRPLLMGTGAVLGLAPAPEYTFIIYVSPVGNYFKEGVAPINLIVEnEFHRATPGGTGGVKTIGNYAAVLKAQSIAKA 276
Cdd:cd01557 80 SLYIRPFIFGTDPQLGVSPALEYLFAVFASPVGAYFKGGEKGVSALVS-SFRRAAPGGPGAAKAGGNYAASLLAQKEAAE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 277 KGYSDVLYLDCIyKRYLEEVSSCNIFIVKDNVISTPEIKGTILPGITRKSMIDVARTQGFQVEERNVTVDELLEADEVFC 356
Cdd:cd01557 159 KGYDQALWLDGA-HGYVAEVGTMNIFFVKDGELITPPLDGSILPGITRDSILELARDLGIKVEERPITRDELYEADEVFA 237
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 18408919 357 TGTAVVVSPVGSVTYKGKRVSYGEGtfGTVSKQLYTVLTSLQMG 400
Cdd:cd01557 238 TGTAAVVTPVGEIDYRGKEPGEGEV--GPVTKKLYDLLTDIQYG 279
|
|
| ilvE_II |
TIGR01123 |
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are ... |
108-412 |
9.34e-127 |
|
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family less similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 233278 Cd Length: 313 Bit Score: 368.32 E-value: 9.34e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 108 GELQRFGNIEISPSAGVLNYGQGLFEGLKAYRKKDGNnILLFRPEENAKRMRNGAERMCMPAPTVEQFVEAVTETVLANK 187
Cdd:TIGR01123 4 GRLTPYGPLHLDPGSTVLHYGQECFEGLKAYRCADGS-IVLFRPDANAARLRRSARRLLMPELPDELFLEALRQLVKANK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 188 RWVPPPGKG-SLYVRPLLMGTGAVLGLAPAPEYTFIIYVSPVGNYFKEGVAPINLIVENEFHRATPGGTGGVKTIGNYAA 266
Cdd:TIGR01123 83 DWVPPYGSGaSLYLRPFVIGTEPNLGVRPAPEYLFYVFASPVGAYFKGGLAPVSIFVTTEYDRAAPGGTGAVKVGGNYAA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 267 VLKAQSIAKAKGYSDVLYLDCIYKRYLEEVSSCNIF-IVKDNVISTPEIKGTILPGITRKSMIDVARTQGFQVEERNVTV 345
Cdd:TIGR01123 163 SLLAQAKAAEQGCDQVVYLDPVEHTYIEEVGAMNFFfITGDGELVTPPLSGSILPGITRDSLLQLAKDLGMEVEERRIDI 242
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18408919 346 DELLEADE----VFCTGTAVVVSPVGSVTYKGKRVSYGEGTFGTVSKQLYTVLTSLQMGLIEDNMKWTVNL 412
Cdd:TIGR01123 243 DELKAFVEageiVFACGTAAVITPVGEIQHGGKEVVFASGQPGEVTKALYDELTDIQYGDFEDPYGWIVEV 313
|
|
| IlvE |
COG0115 |
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ... |
108-404 |
4.69e-96 |
|
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 439885 [Multi-domain] Cd Length: 285 Bit Score: 289.01 E-value: 4.69e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 108 GELQRFGNIEISPSAGVLNYGQGLFEGLKAYrkkDGNnilLFRPEENAKRMRNGAERMCMPAP-TVEQFVEAVTETVLAN 186
Cdd:COG0115 7 GELVPEEEATISVLDRGLHYGDGVFEGIRAY---DGR---LFRLDEHLARLNRSAKRLGIPIPyTEEELLEAIRELVAAN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 187 krwvpppGKGSLYVRPLLMGTGAVLGL-APAPEYTFIIYVSPVGNYFKEGVA-PINLIVEnEFHRATPGGTGGVKTiGNY 264
Cdd:COG0115 81 -------GLEDGYIRPQVTRGVGGRGVfAEEYEPTVIIIASPLPAYPAEAYEkGVRVITS-PYRRAAPGGLGGIKT-GNY 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 265 AAVLKAQSIAKAKGYSDVLYLDciYKRYLEEVSSCNIFIVKDNVISTPEIKGTILPGITRKSMIDVARTQGFQVEERNVT 344
Cdd:COG0115 152 LNNVLAKQEAKEAGADEALLLD--TDGYVAEGSGSNVFIVKDGVLVTPPLSGGILPGITRDSVIELARELGIPVEERPIS 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 345 VDELLEADEVFCTGTAVVVSPVGSVtykgKRVSYGEGTFGTVSKQLYTVLTSLQMGLIED 404
Cdd:COG0115 230 LEELYTADEVFLTGTAAEVTPVTEI----DGRPIGDGKPGPVTRRLRELYTDIVRGEAED 285
|
|
| Aminotran_4 |
pfam01063 |
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ... |
130-369 |
1.53e-43 |
|
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.
Pssm-ID: 395844 [Multi-domain] Cd Length: 221 Bit Score: 151.36 E-value: 1.53e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 130 GLFEGLKAYRKKdgnnilLFRPEENAKRMRNGAERMCMPAPTVEQFVEAVTETVLANKRWVPPpgkgslYVRPLLMGTGA 209
Cdd:pfam01063 1 GVFETLRVYNGK------IFFLDEHLARLRRSAKLLGIPLPFDEEDLRKIIEELLKANGLGVG------RLRLTVSRGPG 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 210 VLGLaPAPEYTFIIYVSPvgnYFKEGVAPINLIVENEFHRATPGGTGGVKTiGNYAAVLKAQSIAKAKGYSDVLYLDciY 289
Cdd:pfam01063 69 GFGL-PTSDPTLAIFVSA---LPPPPESKKKGVISSLVRRNPPSPLPGAKT-LNYLENVLARREAKAQGADDALLLD--E 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 290 KRYLEEVSSCNIFIVKDNVISTPEIKGTILPGITRKSMIDVARTQGFQVEERNVTVDELLEADEVFCTGTAVVVSPVGSV 369
Cdd:pfam01063 142 DGNVTEGSTSNVFLVKGGTLYTPPLESGILPGITRQALLDLAKALGLEVEERPITLADLQEADEAFLTNSLRGVTPVSSI 221
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02782 |
PLN02782 |
Branched-chain amino acid aminotransferase |
13-413 |
0e+00 |
|
Branched-chain amino acid aminotransferase
Pssm-ID: 215418 Cd Length: 403 Bit Score: 824.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 13 NYLLCPSRAFSTRLHSSTRNLSPPSFASIKLQHSSSSVSSN----GGISLTRCNAVSSNSSsTLVTELADIDWDTVGFGL 88
Cdd:PLN02782 1 NYLLCPSRAFSTRLHSSSRRLNFPPPSSLSLRHSNSSVSSNpissKAISLTRCDAVSSSSY-TEVTELADIDWDNLGFGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 89 KPADYMYVMKCNIDGEFSKGELQRFGNIEISPSAGVLNYGQGLFEGLKAYRKKDGNnILLFRPEENAKRMRNGAERMCMP 168
Cdd:PLN02782 80 VPTDYMYIMKCNRDGEFSKGELQRFGNIELSPSAGVLNYGQGLFEGLKAYRKEDGN-ILLFRPEENAIRMRNGAERMCMP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 169 APTVEQFVEAVTETVLANKRWVPPPGKGSLYVRPLLMGTGAVLGLAPAPEYTFIIYVSPVGNYFKEGVAPINLIVENEFH 248
Cdd:PLN02782 159 APTVEQFVEAVKETVLANKRWVPPPGKGSLYIRPLLMGSGAVLGLAPAPEYTFLIYVSPVGNYFKEGVAPINLIVENEFH 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 249 RATPGGTGGVKTIGNYAAVLKAQSIAKAKGYSDVLYLDCIYKRYLEEVSSCNIFIVKDNVISTPEIKGTILPGITRKSMI 328
Cdd:PLN02782 239 RATPGGTGGVKTIGNYAAVLKAQSIAKAKGYSDVLYLDCVHKKYLEEVSSCNIFIVKDNVISTPAIKGTILPGITRKSII 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 329 DVARTQGFQVEERNVTVDELLEADEVFCTGTAVVVSPVGSVTYKGKRVSYGEGTFGTVSKQLYTVLTSLQMGLIEDNMKW 408
Cdd:PLN02782 319 DVARSQGFQVEERNVTVDELLEADEVFCTGTAVVVSPVGSITYKGKRVSYGEGGFGTVSQQLYTVLTSLQMGLIEDNMNW 398
|
....*
gi 18408919 409 TVNLS 413
Cdd:PLN02782 399 TVELS 403
|
|
| PLN03117 |
PLN03117 |
Branched-chain-amino-acid aminotransferase; Provisional |
68-412 |
1.17e-168 |
|
Branched-chain-amino-acid aminotransferase; Provisional
Pssm-ID: 178664 Cd Length: 355 Bit Score: 476.35 E-value: 1.17e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 68 SSSTLVTELAD-----IDWDTVGFGLKPADYMYVMKCNIDGEFSKGELQRFGNIEISPSAGVLNYGQGLFEGLKAYRKKD 142
Cdd:PLN03117 4 SSSPLPTSKADekyanVKWEELGFALVPTDYMYVAKCKQGESFSEGKIVPYGDISISPCAGILNYGQGLFEGLKAYRTED 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 143 GNnILLFRPEENAKRMRNGAERMCMPAPTVEQFVEAVTETVLANKRWVPPPGKGSLYVRPLLMGTGAVLGLAPAPEYTFI 222
Cdd:PLN03117 84 GR-ITLFRPDQNALRMQTGADRLCMTPPSLEQFVEAVKQTVLANKKWVPPPGKGTLYIRPLLIGSGAVLGVAPAPEYTFL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 223 IYVSPVGNYFKEGvAPINLIVENEFHRATPGGTGGVKTIGNYAAVLKAQSIAKAKGYSDVLYLDCIYKRYLEEVSSCNIF 302
Cdd:PLN03117 163 IYASPVGNYHKAS-SGLNLKVDHKHRRAHSGGTGGVKSCTNYSPVVKSLIEAKSSGFSDVLFLDAATGKNIEELSACNIF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 303 IVKDNVISTPEIKGTILPGITRKSMIDVARTQGFQVEERNVTVDELLEADEVFCTGTAVVVSPVGSVTYKGKRVSY--GE 380
Cdd:PLN03117 242 ILKGNIVSTPPTSGTILPGVTRKSISELARDIGYQVEERDVSVDELLEAEEVFCTGTAVVVKAVETVTFHDKKVKYrtGE 321
|
330 340 350
....*....|....*....|....*....|..
gi 18408919 381 GTFGTvskQLYTVLTSLQMGLIEDNMKWTVNL 412
Cdd:PLN03117 322 EALST---KLHLILTNIQMGVVEDKKGWMVEI 350
|
|
| PLN02259 |
PLN02259 |
branched-chain-amino-acid aminotransferase 2 |
75-413 |
1.68e-167 |
|
branched-chain-amino-acid aminotransferase 2
Pssm-ID: 177901 Cd Length: 388 Bit Score: 474.98 E-value: 1.68e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 75 ELADIDWDTVGFGLKPADYMYVMKCNIDGEFSKGELQRFGNIEISPSAGVLNYGQGLFEGLKAYRKKDGNnILLFRPEEN 154
Cdd:PLN02259 52 VYADLDWDNLGFGLNPADYMYVMKCSKDGEFTQGELSPYGNIQLSPSAGVLNYGQAIYEGTKAYRKENGK-LLLFRPDHN 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 155 AKRMRNGAERMCMPAPTVEQFVEAVTETVLANKRWVPPPGKGSLYVRPLLMGTGAVLGLAPAPEYTFIIYVSPVGNYFKE 234
Cdd:PLN02259 131 AIRMKLGAERMLMPSPSVDQFVNAVKQTALANKRWVPPAGKGTLYIRPLLMGSGPILGLGPAPEYTFIVYASPVGNYFKE 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 235 GVAPINLIVENEFHRATPGGTGGVKTIGNYAAVLKAQSIAKAKGYSDVLYLDCIYKRYLEEVSSCNIFIVKDNVISTPEI 314
Cdd:PLN02259 211 GMAALNLYVEEEYVRAAPGGAGGVKSITNYAPVLKALSRAKSRGFSDVLYLDSVKKKYLEEASSCNVFVVKGRTISTPAT 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 315 KGTILPGITRKSMIDVARTQGFQVEERNVTVDELLEADEVFCTGTAVVVSPVGSVTYKGKRVSYgEGTFGTVSKQLYTVL 394
Cdd:PLN02259 291 NGTILEGITRKSVMEIASDQGYQVVEKAVHVDEVMDADEVFCTGTAVVVAPVGTITYQEKRVEY-KTGDESVCQKLRSVL 369
|
330
....*....|....*....
gi 18408919 395 TSLQMGLIEDNMKWTVNLS 413
Cdd:PLN02259 370 VGIQTGLIEDNKGWVTDIN 388
|
|
| PRK13357 |
PRK13357 |
branched-chain amino acid aminotransferase; Provisional |
74-412 |
2.77e-163 |
|
branched-chain amino acid aminotransferase; Provisional
Pssm-ID: 237363 Cd Length: 356 Bit Score: 462.70 E-value: 2.77e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 74 TELADIDWDTVGFGLKPADYMYVMKCNiDGEFSKGELQRFGNIEISPSAGVLNYGQGLFEGLKAYRKKDGNnILLFRPEE 153
Cdd:PRK13357 12 DEKRAIDWANLGFGYVFTDHMVVIDYK-DGKWHDARLVPYGPLELDPAATVLHYGQEIFEGLKAYRHKDGS-IVLFRPDA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 154 NAKRMRNGAERMCMPAPTVEQFVEAVTETVLANKRWVPPPGKG-SLYVRPLLMGTGAVLGLAPAPEYTFIIYVSPVGNYF 232
Cdd:PRK13357 90 NAKRLQRSADRLLMPELPEELFLEAVKQLVKADRDWVPPYGEGaSLYLRPFMIATEPFLGVKPAEEYIFCVIASPVGAYF 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 233 KEGVAPINLIVENEFHRATPGGTGGVKTIGNYAAVLKAQSIAKAKGYSDVLYLDCIYKRYLEEVSSCNIFIVKDNVISTP 312
Cdd:PRK13357 170 KGGVKPVSIWVSDEYDRAAPGGTGAAKVGGNYAASLLAQAEAKEKGCDQVLYLDAVEHTYIEEVGGMNFFFITKDGTVTP 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 313 EIKGTILPGITRKSMIDVARTQGFQVEERNVTVDELLEA------DEVFCTGTAVVVSPVGSVTYKGKRVSYGEGTFGTV 386
Cdd:PRK13357 250 PLSGSILPGITRDSLLQLAEDLGLTVEERPVSIDEWQADaasgefTEAFACGTAAVITPIGGIKYKDKEFVIGDGEVGPV 329
|
330 340
....*....|....*....|....*.
gi 18408919 387 SKQLYTVLTSLQMGLIEDNMKWTVNL 412
Cdd:PRK13357 330 TQKLYDELTGIQFGDVEDPHGWIVKV 355
|
|
| PLN02883 |
PLN02883 |
Branched-chain amino acid aminotransferase |
75-413 |
8.07e-141 |
|
Branched-chain amino acid aminotransferase
Pssm-ID: 178471 Cd Length: 384 Bit Score: 406.79 E-value: 8.07e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 75 ELADIDWDTVGFGLKPADYMYVMKCNIDGEFSKGELQRFGNIEISPSAGVLNYGQGLFEGLKAYRKKDGNnILLFRPEEN 154
Cdd:PLN02883 48 EYADVDWDKLGFSLVRTDFMFATKSCRDGNFEQGYLSRYGNIELNPAAGILNYGQGLIEGMKAYRGEDGR-ILLFRPELN 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 155 AKRMRNGAERMCMPAPTVEQFVEAVTETVLANKRWVPPPGKGSLYVRPLLMGTGAVLGLAPAPEYTFIIYVSPVGNYFKE 234
Cdd:PLN02883 127 AMRMKIGAERMCMHSPSVHQFIEGVKQTVLANRRWVPPPGKGSLYLRPLLFGSGASLGVAAAPEYTFLVFGSPVQNYFKE 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 235 GVAPINLIVENEFHRATPGGTGGVKTIGNYAAVLKAQSIAKAKGYSDVLYLDCIYKRYLEEVSSCNIFIVKDNVISTPEI 314
Cdd:PLN02883 207 GTAALNLYVEEVIPRAYLGGTGGVKAISNYGPVLEVMRRAKSRGFSDVLYLDADTGKNIEEVSAANIFLVKGNIIVTPAT 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 315 KGTILPGITRKSMIDVARTQGFQVEERNVTVDELLEADEVFCTGTAVVVSPVGSVTYKGKRVSYGEGTfGTVSKQLYTVL 394
Cdd:PLN02883 287 SGTILGGITRKSIIEIALDLGYKVEERRVPVEELKEAEEVFCTGTAAGVASVGSITFKNTRTEYKVGD-GIVTQQLRSIL 365
|
330
....*....|....*....
gi 18408919 395 TSLQMGLIEDNMKWTVNLS 413
Cdd:PLN02883 366 LGIQTGSIQDTKDWVLQIA 384
|
|
| BCAT_beta_family |
cd01557 |
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the ... |
117-400 |
4.59e-136 |
|
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two foms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme. The mitochondrial form plays a significant role in skeletal muscle glutamine and alanine synthesis and in interorgan nitrogen metabolism.Members of this subgroup are widely distributed in all three forms of life.
Pssm-ID: 238798 Cd Length: 279 Bit Score: 390.79 E-value: 4.59e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 117 EISPSAGVLNYGQGLFEGLKAYRKKDGNnILLFRPEENAKRMRNGAERMCMPAPTVEQFVEAVTETVLANKRWVPPPGKG 196
Cdd:cd01557 1 SLHPATHALHYGQAVFEGLKAYRTPDGK-IVLFRPDENAERLNRSARRLGLPPFSVEEFIDAIKELVKLDADWVPYGGGA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 197 SLYVRPLLMGTGAVLGLAPAPEYTFIIYVSPVGNYFKEGVAPINLIVEnEFHRATPGGTGGVKTIGNYAAVLKAQSIAKA 276
Cdd:cd01557 80 SLYIRPFIFGTDPQLGVSPALEYLFAVFASPVGAYFKGGEKGVSALVS-SFRRAAPGGPGAAKAGGNYAASLLAQKEAAE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 277 KGYSDVLYLDCIyKRYLEEVSSCNIFIVKDNVISTPEIKGTILPGITRKSMIDVARTQGFQVEERNVTVDELLEADEVFC 356
Cdd:cd01557 159 KGYDQALWLDGA-HGYVAEVGTMNIFFVKDGELITPPLDGSILPGITRDSILELARDLGIKVEERPITRDELYEADEVFA 237
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 18408919 357 TGTAVVVSPVGSVTYKGKRVSYGEGtfGTVSKQLYTVLTSLQMG 400
Cdd:cd01557 238 TGTAAVVTPVGEIDYRGKEPGEGEV--GPVTKKLYDLLTDIQYG 279
|
|
| ilvE_II |
TIGR01123 |
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are ... |
108-412 |
9.34e-127 |
|
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family less similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 233278 Cd Length: 313 Bit Score: 368.32 E-value: 9.34e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 108 GELQRFGNIEISPSAGVLNYGQGLFEGLKAYRKKDGNnILLFRPEENAKRMRNGAERMCMPAPTVEQFVEAVTETVLANK 187
Cdd:TIGR01123 4 GRLTPYGPLHLDPGSTVLHYGQECFEGLKAYRCADGS-IVLFRPDANAARLRRSARRLLMPELPDELFLEALRQLVKANK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 188 RWVPPPGKG-SLYVRPLLMGTGAVLGLAPAPEYTFIIYVSPVGNYFKEGVAPINLIVENEFHRATPGGTGGVKTIGNYAA 266
Cdd:TIGR01123 83 DWVPPYGSGaSLYLRPFVIGTEPNLGVRPAPEYLFYVFASPVGAYFKGGLAPVSIFVTTEYDRAAPGGTGAVKVGGNYAA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 267 VLKAQSIAKAKGYSDVLYLDCIYKRYLEEVSSCNIF-IVKDNVISTPEIKGTILPGITRKSMIDVARTQGFQVEERNVTV 345
Cdd:TIGR01123 163 SLLAQAKAAEQGCDQVVYLDPVEHTYIEEVGAMNFFfITGDGELVTPPLSGSILPGITRDSLLQLAKDLGMEVEERRIDI 242
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18408919 346 DELLEADE----VFCTGTAVVVSPVGSVTYKGKRVSYGEGTFGTVSKQLYTVLTSLQMGLIEDNMKWTVNL 412
Cdd:TIGR01123 243 DELKAFVEageiVFACGTAAVITPVGEIQHGGKEVVFASGQPGEVTKALYDELTDIQYGDFEDPYGWIVEV 313
|
|
| IlvE |
COG0115 |
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ... |
108-404 |
4.69e-96 |
|
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 439885 [Multi-domain] Cd Length: 285 Bit Score: 289.01 E-value: 4.69e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 108 GELQRFGNIEISPSAGVLNYGQGLFEGLKAYrkkDGNnilLFRPEENAKRMRNGAERMCMPAP-TVEQFVEAVTETVLAN 186
Cdd:COG0115 7 GELVPEEEATISVLDRGLHYGDGVFEGIRAY---DGR---LFRLDEHLARLNRSAKRLGIPIPyTEEELLEAIRELVAAN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 187 krwvpppGKGSLYVRPLLMGTGAVLGL-APAPEYTFIIYVSPVGNYFKEGVA-PINLIVEnEFHRATPGGTGGVKTiGNY 264
Cdd:COG0115 81 -------GLEDGYIRPQVTRGVGGRGVfAEEYEPTVIIIASPLPAYPAEAYEkGVRVITS-PYRRAAPGGLGGIKT-GNY 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 265 AAVLKAQSIAKAKGYSDVLYLDciYKRYLEEVSSCNIFIVKDNVISTPEIKGTILPGITRKSMIDVARTQGFQVEERNVT 344
Cdd:COG0115 152 LNNVLAKQEAKEAGADEALLLD--TDGYVAEGSGSNVFIVKDGVLVTPPLSGGILPGITRDSVIELARELGIPVEERPIS 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 345 VDELLEADEVFCTGTAVVVSPVGSVtykgKRVSYGEGTFGTVSKQLYTVLTSLQMGLIED 404
Cdd:COG0115 230 LEELYTADEVFLTGTAAEVTPVTEI----DGRPIGDGKPGPVTRRLRELYTDIVRGEAED 285
|
|
| PLPDE_IV |
cd00449 |
PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, ... |
124-394 |
1.10e-94 |
|
PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate lyases (ADCL). BCAT catalyzes the reversible transamination reaction between the L-branched-chain amino and alpha-keto acids. DAAT catalyzes the synthesis of D-glutamic acid and D-alanine, and ADCL converts 4-amino-4-deoxychorismate to p-aminobenzoate and pyruvate. Except for a few enzymes, i. e., Escherichia coli and Salmonella BCATs, which are homohexamers arranged as a double trimer, the class IV PLPDEs are homodimers. Homodimer formation is required for catalytic activity.
Pssm-ID: 238254 [Multi-domain] Cd Length: 256 Bit Score: 284.49 E-value: 1.10e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 124 VLNYGQGLFEGLKAYrkkdgnNILLFRPEENAKRMRNGAERMCMPAP-TVEQFVEAVTETVLANKrwvpppgKGSLYVRP 202
Cdd:cd00449 3 GLHYGDGVFEGLRAG------KGRLFRLDEHLDRLNRSAKRLGLPIPyDREELREALKELVAANN-------GASLYIRP 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 203 LLMGTGAVLGLAPAP--EYTFIIYVSPVGNYFKEGVAPINLIVENEFHRATPGGTGGVKTiGNYAAVLKAQSIAKAKGYS 280
Cdd:cd00449 70 LLTRGVGGLGVAPPPspEPTFVVFASPVGAYAKGGEKGVRLITSPDRRRAAPGGTGDAKT-GGNLNSVLAKQEAAEAGAD 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 281 DVLYLDCiyKRYLEEVSSCNIFIVKDNVISTPEIKGTILPGITRKSMIDVARTQGFQVEERNVTVDELLEADEVFCTGTA 360
Cdd:cd00449 149 EALLLDD--NGYVTEGSASNVFIVKDGELVTPPLDGGILPGITRDSVIELAKELGIKVEERPISLDELYAADEVFLTGTA 226
|
250 260 270
....*....|....*....|....*....|....
gi 18408919 361 VVVSPVGSVTYKGKrvsyGEGTFGTVSKQLYTVL 394
Cdd:cd00449 227 AEVTPVTEIDGRGI----GDGKPGPVTRKLRELL 256
|
|
| PRK06606 |
PRK06606 |
branched-chain amino acid transaminase; |
125-408 |
2.76e-50 |
|
branched-chain amino acid transaminase;
Pssm-ID: 235841 Cd Length: 306 Bit Score: 171.87 E-value: 2.76e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 125 LNYGQGLFEGLKAYRKKDGNNIllFRPEENAKRMRNGAERMCMPAP-TVEQFVEAVTETVLANKRwvpppgkGSLYVRPL 203
Cdd:PRK06606 30 LHYGTGVFEGIRAYDTPKGPAI--FRLREHTKRLFNSAKILRMEIPySVDELMEAQREVVRKNNL-------KSAYIRPL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 204 LMgTGAvLGLAPAPEYT---FIIYVSPVGNY-----FKEGvapINLIVeNEFHRATPGGT-GGVKTIGNYAAVLKAQSIA 274
Cdd:PRK06606 101 VF-VGD-EGLGVRPHGLptdVAIAAWPWGAYlgeeaLEKG---IRVKV-SSWTRHAPNSIpTRAKASGNYLNSILAKTEA 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 275 KAKGYSDVLYLDciYKRYLEEVSSCNIFIVKDNVISTPEIKGTILPGITRKSMIDVARTQGFQVEERNVTVDELLEADEV 354
Cdd:PRK06606 175 RRNGYDEALLLD--VEGYVSEGSGENIFIVRDGVLYTPPLTSSILEGITRDTVITLAKDLGIEVIERRITRDELYIADEV 252
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 18408919 355 FCTGTAVVVSPVGSVtykgKRVSYGEGTFGTVSKQLYTVLTSLQMGLIEDNMKW 408
Cdd:PRK06606 253 FFTGTAAEVTPIREV----DGRQIGNGKRGPITEKLQSAYFDIVRGRTEKYAHW 302
|
|
| ilvE_I |
TIGR01122 |
branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are ... |
108-408 |
4.24e-50 |
|
branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family more strongly similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 130192 Cd Length: 298 Bit Score: 171.00 E-value: 4.24e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 108 GELQRFGNIEISPSAGVLNYGQGLFEGLKAYRKKDGNNIllFRPEENAKRMRNGAERMCMPAP-TVEQFVEAVTETVLAN 186
Cdd:TIGR01122 4 GEFVDWEDAKVHVLTHALHYGTGVFEGIRAYDTDKGPAI--FRLKEHIQRLYDSAKIYRMEIPySKEELMEATRETLRKN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 187 krwvpppGKGSLYVRPLLMGTGAVLGLAPAPEYT--FIIYVSPVGNYFKEGVAP--INLIVENeFHRATPGGT-GGVKTI 261
Cdd:TIGR01122 82 -------NLRSAYIRPLVFRGDGDLGLNPRAGYKpdVIIAAWPWGAYLGEEALEkgIDAKVSS-WRRNAPNTIpTAAKAG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 262 GNYAAVLKAQSIAKAKGYSDVLYLDciYKRYLEEVSSCNIFIVKDNVISTPEIKGTILPGITRKSMIDVARTQGFQVEER 341
Cdd:TIGR01122 154 GNYLNSLLAKSEARRHGYDEAILLD--VEGYVAEGSGENIFIVKDGVLFTPPVTSSILPGITRDTVITLAKELGIEVVEQ 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18408919 342 NVTVDELLEADEVFCTGTAVVVSPVGSVtyKGKRVsyGEGTFGTVSKQLYTVLTSLQMGLIEDNMKW 408
Cdd:TIGR01122 232 PISREELYTADEAFFTGTAAEITPIREV--DGRKI--GNGRRGPVTKKLQEAFFDLVTGGTEDYWGW 294
|
|
| Aminotran_4 |
pfam01063 |
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ... |
130-369 |
1.53e-43 |
|
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.
Pssm-ID: 395844 [Multi-domain] Cd Length: 221 Bit Score: 151.36 E-value: 1.53e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 130 GLFEGLKAYRKKdgnnilLFRPEENAKRMRNGAERMCMPAPTVEQFVEAVTETVLANKRWVPPpgkgslYVRPLLMGTGA 209
Cdd:pfam01063 1 GVFETLRVYNGK------IFFLDEHLARLRRSAKLLGIPLPFDEEDLRKIIEELLKANGLGVG------RLRLTVSRGPG 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 210 VLGLaPAPEYTFIIYVSPvgnYFKEGVAPINLIVENEFHRATPGGTGGVKTiGNYAAVLKAQSIAKAKGYSDVLYLDciY 289
Cdd:pfam01063 69 GFGL-PTSDPTLAIFVSA---LPPPPESKKKGVISSLVRRNPPSPLPGAKT-LNYLENVLARREAKAQGADDALLLD--E 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 290 KRYLEEVSSCNIFIVKDNVISTPEIKGTILPGITRKSMIDVARTQGFQVEERNVTVDELLEADEVFCTGTAVVVSPVGSV 369
Cdd:pfam01063 142 DGNVTEGSTSNVFLVKGGTLYTPPLESGILPGITRQALLDLAKALGLEVEERPITLADLQEADEAFLTNSLRGVTPVSSI 221
|
|
| D-AAT_like |
cd01558 |
D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes ... |
127-394 |
1.36e-34 |
|
D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-glutamate in addition to other D-amino acids. The enzyme like other members of this superfamily requires PLP as a cofactor. Members of this subgroup are found in all three forms of life.
Pssm-ID: 238799 [Multi-domain] Cd Length: 270 Bit Score: 129.26 E-value: 1.36e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 127 YGQGLFEGLKAYRKKdgnnilLFRPEENAKRMRNGAERMCMPAP-TVEQFVEAVTETVLANKRwvpppGKGSLYVRpLLM 205
Cdd:cd01558 23 FGDGVYEVIRVYNGK------PFALDEHLDRLYRSAKELRIDIPyTREELKELIRELVAKNEG-----GEGDVYIQ-VTR 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 206 GTGAVLGLAPAPEYTFIIYVS-----PVGNYFKEGVAPINLIVENEFHRAtpggtggVKTIGNYAAVLKAQsIAKAKGYS 280
Cdd:cd01558 91 GVGPRGHDFPKCVKPTVVIITqplplPPAELLEKGVRVITVPDIRWLRCD-------IKSLNLLNNVLAKQ-EAKEAGAD 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 281 DVLYLDciYKRYLEEVSSCNIFIVKDNVISTPEIKGTILPGITRKSMIDVARTQGFQVEERNVTVDELLEADEVFCTGTA 360
Cdd:cd01558 163 EAILLD--ADGLVTEGSSSNVFIVKNGVLVTPPLDNGILPGITRATVIELAKELGIPVEERPFSLEELYTADEVFLTSTT 240
|
250 260 270
....*....|....*....|....*....|....
gi 18408919 361 VVVSPVGSVtyKGKRVsyGEGTFGTVSKQLYTVL 394
Cdd:cd01558 241 AEVMPVVEI--DGRPI--GDGKPGPVTKRLREAY 270
|
|
| PRK07544 |
PRK07544 |
branched-chain amino acid aminotransferase; Validated |
125-390 |
6.04e-30 |
|
branched-chain amino acid aminotransferase; Validated
Pssm-ID: 181025 Cd Length: 292 Bit Score: 117.38 E-value: 6.04e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 125 LNYGQGLFEGLKAYrkkdGNNIllFRPEENAKRMRNGAERMCMPAP-TVEQFVEAVTETVLANkrwvpppGKGSLYVRPL 203
Cdd:PRK07544 32 LHYASSVFEGERAY----GGKI--FKLREHSERLRRSAELLDFEIPySVAEIDAAKKETLAAN-------GLTDAYVRPV 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 204 ------LMGTGAvlglaPAPEYTFIIYVSPVGNYF--KEGVAPINLIVeNEFHRATPggtggvKTIGNYAavlKAQSI-- 273
Cdd:PRK07544 99 awrgseMMGVSA-----QQNKIHLAIAAWEWPSYFdpEAKMKGIRLDI-AKWRRPDP------ETAPSAA---KAAGLym 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 274 --------AKAKGYSDVLYLDciYKRYLEEVSSCNIFIVKDNVISTPeIKGTILPGITRKSMIDVARTQGFQVEERNVTV 345
Cdd:PRK07544 164 ictiskhaAEAKGYADALMLD--YRGYVAEATGANIFFVKDGVIHTP-TPDCFLDGITRQTVIELAKRRGIEVVERHIMP 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 18408919 346 DELLEADEVFCTGTAVVVSPVGSVtykgkrvsyGEGTF--GTVSKQL 390
Cdd:PRK07544 241 EELAGFSECFLTGTAAEVTPVSEI---------GEYRFtpGAITRDL 278
|
|
| PRK08320 |
PRK08320 |
branched-chain amino acid aminotransferase; Reviewed |
123-390 |
1.37e-29 |
|
branched-chain amino acid aminotransferase; Reviewed
Pssm-ID: 236238 [Multi-domain] Cd Length: 288 Bit Score: 116.12 E-value: 1.37e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 123 GVLnYGQGLFEGLKAYrkkDGNnilLFRPEENAKRMRNGAERMCMPAP-TVEQFVEAVTETVLANkrwvpppGKGSLYVR 201
Cdd:PRK08320 25 GFL-YGDGVFEGIRAY---NGR---VFRLKEHIDRLYDSAKAIMLEIPlSKEEMTEIVLETLRKN-------NLRDAYIR 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 202 PLLM-GTGAvLGLAP--APEYTFIIYVSPVGNYFKE----GVAPINLIVenefhRATPGGT--GGVKTIgNYAAVLKAQS 272
Cdd:PRK08320 91 LVVSrGVGD-LGLDPrkCPKPTVVCIAEPIGLYPGElyekGLKVITVST-----RRNRPDAlsPQVKSL-NYLNNILAKI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 273 IAKAKGYSDVLYLDciYKRYLEEVSSCNIFIVKDNVISTPEIKGTILPGITRKSMIDVARTQGFQVEERNVTVDELLEAD 352
Cdd:PRK08320 164 EANLAGVDEAIMLN--DEGYVAEGTGDNIFIVKNGKLITPPTYAGALEGITRNAVIEIAKELGIPVREELFTLHDLYTAD 241
|
250 260 270
....*....|....*....|....*....|....*...
gi 18408919 353 EVFCTGTAVVVSPVgsVTYKGKRVsyGEGTFGTVSKQL 390
Cdd:PRK08320 242 EVFLTGTAAEVIPV--VKVDGRVI--GDGKPGPITKKL 275
|
|
| PRK12479 |
PRK12479 |
branched-chain-amino-acid transaminase; |
127-390 |
3.70e-23 |
|
branched-chain-amino-acid transaminase;
Pssm-ID: 183549 [Multi-domain] Cd Length: 299 Bit Score: 98.49 E-value: 3.70e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 127 YGQGLFEGLKAYrkkdGNNIllFRPEENAKRMRNGAERMCMPAP-TVEQFVEAVTETVLANkrwvpppGKGSLYVRPLLM 205
Cdd:PRK12479 29 YGDGVFEGIRSY----GGNV--FCLKEHVKRLYESAKSILLTIPlTVDEMEEAVLQTLQKN-------EYADAYIRLIVS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 206 GTGAVLGLAP--APEYTFIIYVSPVGNYFKEGVAPINLIVENEFHRATPGGTG-GVKTIGNYAAVLKAQSIAKAkGYSDV 282
Cdd:PRK12479 96 RGKGDLGLDPrsCVKPSVIIIAEQLKLFPQEFYDNGLSVVSVASRRNTPDALDpRIKSMNYLNNVLVKIEAAQA-GVLEA 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 283 LYLDciYKRYLEEVSSCNIFIVKDNVISTPEIKGTILPGITRKSMIDVARTQGFQVEERNVTVDELLEADEVFCTGTAVV 362
Cdd:PRK12479 175 LMLN--QQGYVCEGSGDNVFVVKDGKVLTPPSYLGALEGITRNSVIELCERLSIPCEERPFTRHDVYVADEVFLTGTAAE 252
|
250 260
....*....|....*....|....*...
gi 18408919 363 VSPVgsVTYKGKRVsyGEGTFGTVSKQL 390
Cdd:PRK12479 253 LIPV--VKVDSREI--GDGKPGSVTKQL 276
|
|
| PRK13356 |
PRK13356 |
branched-chain amino acid aminotransferase; |
156-366 |
1.44e-22 |
|
branched-chain amino acid aminotransferase;
Pssm-ID: 237362 Cd Length: 286 Bit Score: 96.56 E-value: 1.44e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 156 KRMRNGAERMCM-PAPTVEQFVEAVTETVlanKRWvppPGKGSLYVRPLLMG-TGAVLGLAPAPEYT---FIIYVSPVGN 230
Cdd:PRK13356 55 ARVNRSAEALGLkPTVSAEEIEALAREGL---KRF---DPDTALYIRPMYWAeDGFASGVAPDPESTrfaLCLEEAPMPE 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 231 yfKEGVApinlIVENEFHRATPG-GTGGVKTIGNYAAVLKAQSIAKAKGYSDVLYLDCIYKryLEEVSSCNIFIVKDNVI 309
Cdd:PRK13356 129 --PTGFS----LTLSPFRRPTLEmAPTDAKAGCLYPNNARALREARSRGFDNALVLDMLGN--VAETATSNVFMVKDGVV 200
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 18408919 310 STPEIKGTILPGITRKSMIDVARTQGFQVEERNVTVDELLEADEVFCTGTAVVVSPV 366
Cdd:PRK13356 201 FTPVPNGTFLNGITRQRVIALLREDGVTVVETTLTYEDFLEADEVFSTGNYSKVVPV 257
|
|
| ADCL_like |
cd01559 |
ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent ... |
127-366 |
2.74e-22 |
|
ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most members of this subgroup are likely to function as dimers. The enzyme from E.Coli, the structure of which is available, is a homodimer that is folded into a small and a larger domain. The coenzyme pyridoxal 5; -phosphate resides at the interface of the two domains that is linked by a flexible loop. Members of this subgroup are found in Eukaryotes and bacteria.
Pssm-ID: 238800 [Multi-domain] Cd Length: 249 Bit Score: 95.07 E-value: 2.74e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 127 YGQGLFEGLKAYrkkDGNNILLfrpEENAKRMRNGAERMCMPAPTVEQFVEAVTETVLANkrwvpPPGKGslYVRPLLMG 206
Cdd:cd01559 6 YGDGVFETMRAL---DGRLFLL---DAHLARLERSARRLGIPEPDLPRLRAALESLLAAN-----DIDEG--RIRLILSR 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 207 TGAVLGLAPA--PEYTFIIYVSPVGNYFKE-GVAPINLIVENEfhraTPGGTGGVKTIgNYA-AVLKAQSIAKAkGYSDV 282
Cdd:cd01559 73 GPGGRGYAPSvcPGPALYVSVIPLPPAWRQdGVRLITCPVRLG----EQPLLAGLKHL-NYLeNVLAKREARDR-GADEA 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 283 LYLDCiyKRYLEEVSSCNIFIVKDNVISTPEIKGTILPGITRKSMIDVARTQGFQVEERNVTVDELLEADEVFCTGTAVV 362
Cdd:cd01559 147 LFLDT--DGRVIEGTASNLFFVKDGELVTPSLDRGGLAGITRQRVIELAAAKGYAVDERPLRLEDLLAADEAFLTNSLLG 224
|
....
gi 18408919 363 VSPV 366
Cdd:cd01559 225 VAPV 228
|
|
| PRK06680 |
PRK06680 |
D-amino acid aminotransferase; Reviewed |
258-390 |
3.76e-20 |
|
D-amino acid aminotransferase; Reviewed
Pssm-ID: 180656 [Multi-domain] Cd Length: 286 Bit Score: 89.60 E-value: 3.76e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 258 VKTIGNYAAVLkAQSIAKAKGYSDVLYLDciyKRYLEEVSSCNIFIV-KDNVISTPEIKGTILPGITRKSMIDVARTQGF 336
Cdd:PRK06680 148 IKSVGLLPNVL-AKQAAKEAGAQEAWMVD---DGFVTEGASSNAWIVtKDGKLVTRPADNFILPGITRHTLIDLAKELGL 223
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 18408919 337 QVEERNVTVDELLEADEVFCTGTAVVVSPVgsVTYKGKRVsyGEGTFGTVSKQL 390
Cdd:PRK06680 224 EVEERPFTLQEAYAAREAFITAASSFVFPV--VQIDGKQI--GNGKPGPIAKRL 273
|
|
| PRK07849 |
PRK07849 |
aminodeoxychorismate lyase; |
128-369 |
3.78e-19 |
|
aminodeoxychorismate lyase;
Pssm-ID: 236114 [Multi-domain] Cd Length: 292 Bit Score: 86.94 E-value: 3.78e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 128 GQGLFEGLKAYrkkDGNNILLfrpEENAKRMRNGAERMCMPAPTVEQFVEAVTetvLANKRWVPPPGKGSL---YVRpll 204
Cdd:PRK07849 38 GDGVFETLLVR---DGRPCNL---EAHLERLARSAALLDLPEPDLDRWRRAVE---LAIEEWRAPEDEAALrlvYSR--- 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 205 mgtgavlGLAPAPEYTFIIYVSPVGNYFK----EGVAPINLivENEFH----RATPGGTGGVKTIgNYAAVLKAQSIAKA 276
Cdd:PRK07849 106 -------GRESGGAPTAWVTVSPVPERVArarrEGVSVITL--DRGYPsdaaERAPWLLAGAKTL-SYAVNMAALRYAAR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 277 KGYSDVLYL--DciyKRYLEEVSScNIFIVKDNVISTPEIKGTILPGITRKSMIDVARTQGFQVEERNVTVDELLEADEV 354
Cdd:PRK07849 176 RGADDVIFTstD---GYVLEGPTS-TVVIATDDRLLTPPPWYGILPGTTQAALFEVAREKGWDCEYRALRPADLFAADGV 251
|
250
....*....|....*
gi 18408919 355 FCTGTAVVVSPVGSV 369
Cdd:PRK07849 252 WLVSSVRLAARVHTL 266
|
|
| PRK07650 |
PRK07650 |
4-amino-4-deoxychorismate lyase; Provisional |
93-395 |
1.47e-13 |
|
4-amino-4-deoxychorismate lyase; Provisional
Pssm-ID: 181067 Cd Length: 283 Bit Score: 70.38 E-value: 1.47e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 93 YMYVmkcniDGEFSKGELQRfgnieISP-SAGVLnYGQGLFEGLKAYrkkDGNNILLfrpEENAKRMRNGAERMCMPAPT 171
Cdd:PRK07650 1 LIYV-----NGQYVEEEEAR-----ISPfDHGYL-YGLGVFETFRIY---NGHPFLL---DDHYDRLNDALDTLQIEWTM 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 172 VEQFVEAVTETVL-ANkrwvpppGKGSLYVR-PLLMGTGAvLGLAPAP--EYTFIIYVSPVgnyfkegvAPINLIVENE- 246
Cdd:PRK07650 64 TKDEVLLILKNLLeKN-------GLENAYVRfNVSAGIGE-IGLQTEMyeEPTVIVYMKPL--------APPGLPAEKEg 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 247 ----FHRATPGGtggvktignyAAVLKAQSiakakgysdvlYLDCIY-KR-----------------YLEE--VSscNIF 302
Cdd:PRK07650 128 vvlkQRRNTPEG----------AFRLKSHH-----------YLNNILgKReigndpnkegiflteegYVAEgiVS--NLF 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 303 IVKDNVISTPEIKGTILPGITRKSMIDVARTQGFQVEERNVTVDELLEADEVFCTGTA---VVVSPVGSVTYKGKrvsyg 379
Cdd:PRK07650 185 WVKGDIVYTPSLETGILNGITRAFVIKVLEELGIEVKEGFYTKEELLSADEVFVTNSIqeiVPLTRIEERDFPGK----- 259
|
330
....*....|....*.
gi 18408919 380 EGTFGTVSKQLYTVLT 395
Cdd:PRK07650 260 VGMVTKRLQNLYEMQR 275
|
|
| PRK06092 |
PRK06092 |
4-amino-4-deoxychorismate lyase; Reviewed |
267-366 |
8.45e-10 |
|
4-amino-4-deoxychorismate lyase; Reviewed
Pssm-ID: 235696 Cd Length: 268 Bit Score: 59.08 E-value: 8.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 267 VLKAQSIAKAkGYSDVLYLDcIYKRYLEEVSScNIFIVKDNVISTPEIKGTILPGITRKSMIDVARTQGFQVEERNVTVD 346
Cdd:PRK06092 148 VLIRAELEQT-EADEALVLD-SEGWVIECCAA-NLFWRKGGVVYTPDLDQCGVAGVMRQFILELLAQSGYPVVEVDASLE 224
|
90 100
....*....|....*....|
gi 18408919 347 ELLEADEVFCTGTAVVVSPV 366
Cdd:PRK06092 225 ELLQADEVFICNSLMPVWPV 244
|
|
| PRK12400 |
PRK12400 |
D-amino acid aminotransferase; Reviewed |
270-406 |
1.86e-06 |
|
D-amino acid aminotransferase; Reviewed
Pssm-ID: 171470 Cd Length: 290 Bit Score: 49.25 E-value: 1.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408919 270 AQSIAKAKGYSDVLYldcIYKRYLEEVSSCNIFIVKDNVISTPEIKGTILPGITRKSMIDVARTQGFQVEERNVTVDELL 349
Cdd:PRK12400 161 AATKAERKGCKEALF---VRNGTVTEGSHSNFFLIKNGTLYTHPANHLILNGIIRQYVLSLAKTLRIPVQEELFSVRDVY 237
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 18408919 350 EADEVFCTGTAVVVSPVGSVtyKGKRVSygEGTFGTVSKQLYtvlTSLQMGLIEDNM 406
Cdd:PRK12400 238 QADECFFTGTTIEILPMTHL--DGTAIQ--DGQVGPITKMLQ---RSFSQSLLQSNM 287
|
|
| |
