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Conserved domains on  [gi|18414455|ref|NP_567466|]
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Bax inhibitor-1 family protein [Arabidopsis thaliana]

Protein Classification

Bax inhibitor-1 family protein( domain architecture ID 10179630)

Bax inhibitor-1 family protein similar to protein lifeguard 4 (LFG4/GAAP) which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli and to yeast Bax inhibitor Bxi1p which links the unfolded protein response and programmed cell death and mediates mitochondrial-dependent apoptosis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
 16-255 3.06e-101

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


:

Pssm-ID: 198411  Cd Length: 233  Bit Score: 294.13  E-value: 3.06e-101
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455  16 DRSAGKDIDLEMGVGEATLYPglsygENQLRWGFIRKVYGILSAQLLLTTLISAVVVLNPPVNDLLTGSPGILLFLCIVP 95
Cdd:cd10429   2 SRYAEADIPDDFKYGTNVASA-----EPEIRMAFLRKVYSILSVQLLATTAVSALFYLSPSIKTFVQSHPWLFLISLIGS 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455  96 FILIWPLHIYHQKHPVNLILLALFTVSLSFTVGVSCAMTEGRIVLQALILTLSVVGSLTAYTFWAAkkgKDFSFLGPILF 175
Cdd:cd10429  77 LILLIALYWKRHSHPVNLILLSLFTLCEAYTVGLVVSFYDGKIVLQALILTLGVFVGLTAYTFQTK---RDFSSFGALLF 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455 176 TSLIILVVTSFIQMFFPLGPTSVAVYGGFSALVFCGYIVYDTDNLIKRFTYDEYILASVALYLDILNLFLTILRILRQGD 255
Cdd:cd10429 154 ILLWALILLALIFQFFPYSPTFELVYAGLGALLFSGYIVYDTQLIMKRLSPDEYILAAISLYLDIINLFLSILRILAAMN 233
 
Name Accession Description Interval E-value
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
 16-255 3.06e-101

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 294.13  E-value: 3.06e-101
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455  16 DRSAGKDIDLEMGVGEATLYPglsygENQLRWGFIRKVYGILSAQLLLTTLISAVVVLNPPVNDLLTGSPGILLFLCIVP 95
Cdd:cd10429   2 SRYAEADIPDDFKYGTNVASA-----EPEIRMAFLRKVYSILSVQLLATTAVSALFYLSPSIKTFVQSHPWLFLISLIGS 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455  96 FILIWPLHIYHQKHPVNLILLALFTVSLSFTVGVSCAMTEGRIVLQALILTLSVVGSLTAYTFWAAkkgKDFSFLGPILF 175
Cdd:cd10429  77 LILLIALYWKRHSHPVNLILLSLFTLCEAYTVGLVVSFYDGKIVLQALILTLGVFVGLTAYTFQTK---RDFSSFGALLF 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455 176 TSLIILVVTSFIQMFFPLGPTSVAVYGGFSALVFCGYIVYDTDNLIKRFTYDEYILASVALYLDILNLFLTILRILRQGD 255
Cdd:cd10429 154 ILLWALILLALIFQFFPYSPTFELVYAGLGALLFSGYIVYDTQLIMKRLSPDEYILAAISLYLDIINLFLSILRILAAMN 233
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 47-251 2.29e-41

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 140.77  E-value: 2.29e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455    47 WGFIRKVYGILSAQLLLTTLISAVVVLNPPVNDLLTGSPG--ILLFLCIVPFILIWPLHIYHQK-HPVNLILLALFTVSL 123
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLTAAVAYLVLSSPALLFPSLHPPLfwVLIIAPLGLLFGALLLARKRKYsSNVALLLLLAFTLLM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455   124 SFTVGVSCAMTEGRIVLQALILTLSVVGSLTAYTFWAakkGKDFSFLGPILFTSLIILVVTSFIQMFFPlGPTSVAVYGG 203
Cdd:pfam01027  81 GLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTT---KRDLSFLGGFLFAGLIGLIVASLVNIFLP-SSALSLAISY 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 18414455   204 FSALVFCGYIVYDTDNLIKR-FTYDEY--ILASVALYLDILNLFLTILRIL 251
Cdd:pfam01027 157 LGVLLFSGFILYDTQRIIKRyGEYGDYdaILAALSLYLDFINLFLSLLRIL 207
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 49-251 6.54e-34

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 122.21  E-value: 6.54e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455  49 FIRKVYGILSAQLLLTTLISAVVVLNPPVNDLLTGSPGILLFLCIVPFILIWPLH--IYHQKHPVNLILLALFT----VS 122
Cdd:COG0670  22 VLRNTYGLLALGLLLTALVAYLGMALPGLAALLFGSPGLFWVLLIAPLGLVFLLSklANRANSAAALALLFAYTalmgLT 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455 123 LSFTVGVSCAMTEGRIVLQALILTLSVVGSLTAYtfwAAKKGKDFSFLGPILFTSLIILVVTSFIQMFFPLGPTSVAVYG 202
Cdd:COG0670 102 LSPILLVYTGLSGPASIAQAFGGTAATFGGLSLY---GYTTKRDLSFLGSFLFMGLIGLIIASLVNIFLQSPALSLAISV 178

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 18414455 203 GFsALVFCGYIVYDTDNLIKR-FTYDEYILASVALYLDILNLFLTILRIL 251
Cdd:COG0670 179 AG-VLLFSGLTLYDTQRIKHGyETNKQYIMAALSLYLDFINLFLSLLRLL 227
PRK10447 PRK10447
FtsH protease modulator YccA;
165-251 6.98e-04

FtsH protease modulator YccA;


Pssm-ID: 182469  Cd Length: 219  Bit Score: 39.82  E-value: 6.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455  165 KDFSFLGPILFTSLIILVVTSFIQMFFPLGPTSVAVYGGFsALVFCGYIVYDTDNLIkRFTYDEYILASVALYLDILNLF 244
Cdd:PRK10447 129 KDMSFLGGMLMAGIVVVLIGMVANIFLQLPALHLAISAVF-ILISSGAILFETSNII-HGGETNYIRATVSLYVSLYNIF 206


                 ....*..
gi 18414455  245 LTILRIL 251
Cdd:PRK10447 207 VSLLSIL 213
 
Name Accession Description Interval E-value
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
 16-255 3.06e-101

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 294.13  E-value: 3.06e-101
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455  16 DRSAGKDIDLEMGVGEATLYPglsygENQLRWGFIRKVYGILSAQLLLTTLISAVVVLNPPVNDLLTGSPGILLFLCIVP 95
Cdd:cd10429   2 SRYAEADIPDDFKYGTNVASA-----EPEIRMAFLRKVYSILSVQLLATTAVSALFYLSPSIKTFVQSHPWLFLISLIGS 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455  96 FILIWPLHIYHQKHPVNLILLALFTVSLSFTVGVSCAMTEGRIVLQALILTLSVVGSLTAYTFWAAkkgKDFSFLGPILF 175
Cdd:cd10429  77 LILLIALYWKRHSHPVNLILLSLFTLCEAYTVGLVVSFYDGKIVLQALILTLGVFVGLTAYTFQTK---RDFSSFGALLF 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455 176 TSLIILVVTSFIQMFFPLGPTSVAVYGGFSALVFCGYIVYDTDNLIKRFTYDEYILASVALYLDILNLFLTILRILRQGD 255
Cdd:cd10429 154 ILLWALILLALIFQFFPYSPTFELVYAGLGALLFSGYIVYDTQLIMKRLSPDEYILAAISLYLDIINLFLSILRILAAMN 233
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 47-251 2.29e-41

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 140.77  E-value: 2.29e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455    47 WGFIRKVYGILSAQLLLTTLISAVVVLNPPVNDLLTGSPG--ILLFLCIVPFILIWPLHIYHQK-HPVNLILLALFTVSL 123
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLTAAVAYLVLSSPALLFPSLHPPLfwVLIIAPLGLLFGALLLARKRKYsSNVALLLLLAFTLLM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455   124 SFTVGVSCAMTEGRIVLQALILTLSVVGSLTAYTFWAakkGKDFSFLGPILFTSLIILVVTSFIQMFFPlGPTSVAVYGG 203
Cdd:pfam01027  81 GLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTT---KRDLSFLGGFLFAGLIGLIVASLVNIFLP-SSALSLAISY 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 18414455   204 FSALVFCGYIVYDTDNLIKR-FTYDEY--ILASVALYLDILNLFLTILRIL 251
Cdd:pfam01027 157 LGVLLFSGFILYDTQRIIKRyGEYGDYdaILAALSLYLDFINLFLSLLRIL 207
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 46-251 4.00e-38

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 132.67  E-value: 4.00e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455  46 RWGFIRKVYGILSAQLLLTTLISAVVVLNPPVNDLLTGSPGILLFLCIVPFILIWPLHI---YHQKHPVNLILLALFTVS 122
Cdd:cd10428   8 RRAFIRKVYSILTIQLLVTVAVIALFTFHDPVKKFVRKNPWLYYVSYIVFFITYIALACcegLRRRFPWNLILLGIFTLA 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455 123 LSFTVGVSCAMTEGRIVLQALILTLSVVGSLTAYtfwAAKKGKDFSFLGPILFTSLIILVVTSFIQMFFPlGPTSVAVYG 202
Cdd:cd10428  88 MSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLF---AFQTKYDFTSCGGVLFVLSIVLLIFGIVAIFFY-VKWLHIVYA 163

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 18414455 203 GFSALVFCGYIVYDTDNLIKRFTY----DEYILASVALYLDILNLFLTILRIL 251
Cdd:cd10428 164 SLGALLFSLYLAVDTQLLMGGRKYelspEEYIFAALNIYVDIVNIFLYILQLI 216
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 49-251 6.54e-34

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 122.21  E-value: 6.54e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455  49 FIRKVYGILSAQLLLTTLISAVVVLNPPVNDLLTGSPGILLFLCIVPFILIWPLH--IYHQKHPVNLILLALFT----VS 122
Cdd:COG0670  22 VLRNTYGLLALGLLLTALVAYLGMALPGLAALLFGSPGLFWVLLIAPLGLVFLLSklANRANSAAALALLFAYTalmgLT 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455 123 LSFTVGVSCAMTEGRIVLQALILTLSVVGSLTAYtfwAAKKGKDFSFLGPILFTSLIILVVTSFIQMFFPLGPTSVAVYG 202
Cdd:COG0670 102 LSPILLVYTGLSGPASIAQAFGGTAATFGGLSLY---GYTTKRDLSFLGSFLFMGLIGLIIASLVNIFLQSPALSLAISV 178

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 18414455 203 GFsALVFCGYIVYDTDNLIKR-FTYDEYILASVALYLDILNLFLTILRIL 251
Cdd:COG0670 179 AG-VLLFSGLTLYDTQRIKHGyETNKQYIMAALSLYLDFINLFLSLLRLL 227
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 49-251 1.17e-27

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 105.34  E-value: 1.17e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455  49 FIRKVYGILSAQLLLTTLISAVVVLNPPVndLLTGSPGILLFLCIVPFILIWPLH--IYHQKHPVNLILLALFTVSLSFT 126
Cdd:cd10432   5 FMKKVYGLMAAGLLLTAVGAYVGASTPAL--LLIAGSPLMWVLLIAELALVFGLSfrINKMSVATALPLFFAFAALTGLT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455 127 VGVSCAMTEGRIVLQALILTLSVVGSLTAYtfwAAKKGKDFSFLGPILFTSLIILVVTSFIQMFFPLGPTSVAVYGGfSA 206
Cdd:cd10432  83 LSPILLVYTGASIAQAFFTTAATFGGLSLY---GYTTKKDLSFLGSFLFMGLIGLIIASLVNIFLQSSALQFAISAI-GV 158

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 18414455 207 LVFCGYIVYDTDNLIKR-------FTYDEYILASVALYLDILNLFLTILRIL 251
Cdd:cd10432 159 LIFSGLIAYDTQRIKRMyeagggeSGYKDAIMGALSLYLDFINLFLFLLRLF 210
BI-1-like cd06181
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
 49-251 9.98e-25

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198409  Cd Length: 202  Bit Score: 97.48  E-value: 9.98e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455  49 FIRKVYGILSAQLLLTTLISAVVVLNPPVNDLLTGspgiLLFLCIVPFILIWPLHIYHQKHPVNLILLALFTVSLSFTVG 128
Cdd:cd06181   5 FLRKVYMILALQLLLTAATATAFTVCDPGWYWSPA----LMGLLTSMLALMATAAMIRAKMPVNLILLFGFTGLMGYVVG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455 129 VSCAMTEGRIVLQALILTLSVVGSLTAYTFWAAKkgkDFSFLGPILFTSLIILVVTSFIQMFFPL-GPTSVAVYGGfsAL 207
Cdd:cd06181  81 PLLFFYGPTILLRALGGTALVFFGLTVYALQARK---DFLFLGGPLMAGLGFLLLSFLLNTFFYSpWLHLVAAAVG--LV 155

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 18414455 208 VFCGYIVYDTDNLIKR--FTYDEYILASVALYLDILNLFLTILRIL 251
Cdd:cd06181 156 LFCGFLLYDTQLIIHKaeVGPEDYINACISLYLDIINIFIRLLTIL 201
YccA_like cd10433
YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small ...
 50-251 1.73e-16

YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198415  Cd Length: 205  Bit Score: 75.31  E-value: 1.73e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455  50 IRKVYGILSAQLLLTTLISAVVVLNppvndlltGSPGILLFLCIVPFI-LIWPLHIYHQKhPVNLILLALFTVSLSFTVG 128
Cdd:cd10433   7 LRNTYMLLSMTLAFSALGAGVSMAG--------GSPIMGLLLTLVGAYgLLFLIEKTRNS-AWGIVLVFAFTGFMGYTLG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455 129 ----VSCAMTEG-RIVLQALILTLSVVGSLTAYtfwAAKKGKDFSFLGPILFTSLIILVVTSFIQMFFPLGPTSVAVYGG 203
Cdd:cd10433  78 pilnMYLALPNGgQIIMTALGGTAAIFFGLSAY---ALTTKKDFSFLGGFLFVGAIVLLLAAVANIFLQIPALSLAISAA 154

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 18414455 204 FsALVFCGYIVYDTDNLIKRfTYDEYILASVALYLDILNLFLTILRIL 251
Cdd:cd10433 155 F-VLFSSGFILYDTSRIIHG-GETNYIMATVSLYVSIYNLFVSLLNLL 200
GHITM cd10431
Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in ...
 50-256 4.31e-11

Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in mammalian cells and expression has also been observed in various cancer cell lines. A cytoprotective function has been suggested. It is closely related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect.


Pssm-ID: 198413  Cd Length: 264  Bit Score: 61.24  E-value: 4.31e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455  50 IRKVYGILSAQLLLTTLISAVVVLNPPVNDLLTGSPGILLFLCIVPFI---LIWPLHIYHQKHPVNLILLALFTVSLSFT 126
Cdd:cd10431  44 IHSTYMYFGGSLGLTALAAVALSRSPALMRLMAAGPWLAIGATLAAMIgsgMLVRSYTYPENPGAKHLAWLGHSGVQGAV 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455 127 VGVSCAMTeGRIVLQALILTLSVVGSLtAYTFWAAKKGKdFSFLGPILFTSLIILVVTSFIQMFFPL------GPTSVAV 200
Cdd:cd10431 124 LAPLCFLG-GPLLIRAALYTAGIVGGL-STVAACAPSEK-FLYMGGPLAIGLGVVFASSLGSMFLPPttalgaGLYSVSL 200

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18414455 201 YGGFsaLVFCGYIVYDTDNLIKRFTYDEY--------ILASVALYLDILNLFLTILRILRQGDN 256
Cdd:cd10431 201 YGGL--VLFGGFLLYDTQKIIKRAETHPLygvrkydpINASMSIYMDTINIFIRLVTILAGGGN 262
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 52-256 4.71e-11

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 60.70  E-value: 4.71e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455  52 KVYGILSAQLLLTTLISAVVVLnppvnDLLTGSPGILLFLCIVPFILIWPlhIYHQKHPVNLILLALFT----VSLSFTV 127
Cdd:cd10430  14 KVYLTLAVALLAAAVGAYVHMV-----INIGGLLTGLLSLGLSLWLAFTP--STGKNEPKRLGLLLGFAfltgASLGPLL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455 128 GVSCAMTEgRIVLQALILTLSVVGSLTAYTFWAAKKgkDFSFLGPILFTSLIILVVTSFIQMFFplgpTSVAV-----YG 202
Cdd:cd10430  87 DLVIAINP-SIIVTAFLGTAVIFACFSLAALLAKRR--EYLYLGGLLSSALSILLLVSLANIFG----GSKFLfqaelYL 159

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 18414455 203 GFsaLVFCGYIVYDTDNLIKRFT--YDEYILASVALYLDILNLFLTILRILRQGDN 256
Cdd:cd10430 160 GL--LVFCGFVLFDTQMIIEKAEngDRDYIWHALDLFVDFVALFRRLLIILAKKEK 213
PRK10447 PRK10447
FtsH protease modulator YccA;
165-251 6.98e-04

FtsH protease modulator YccA;


Pssm-ID: 182469  Cd Length: 219  Bit Score: 39.82  E-value: 6.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414455  165 KDFSFLGPILFTSLIILVVTSFIQMFFPLGPTSVAVYGGFsALVFCGYIVYDTDNLIkRFTYDEYILASVALYLDILNLF 244
Cdd:PRK10447 129 KDMSFLGGMLMAGIVVVLIGMVANIFLQLPALHLAISAVF-ILISSGAILFETSNII-HGGETNYIRATVSLYVSLYNIF 206


                 ....*..
gi 18414455  245 LTILRIL 251
Cdd:PRK10447 207 VSLLSIL 213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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