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Conserved domains on  [gi|18414755|ref|NP_567515|]
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alpha/beta-Hydrolases superfamily protein [Arabidopsis thaliana]

Protein Classification

alpha/beta hydrolase; tannase/feruloyl esterase family alpha/beta hydrolase( domain architecture ID 10791465)

uncharacterized alpha/beta hydrolase; may catalyze the cleavage and formation of ester bonds| tannase/feruloyl esterase family alpha/beta hydrolase similar to Aspergillus oryzae tannase and Aspergillus niger feruloyl esterase B

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02802 PLN02802
triacylglycerol lipase
 8-515 0e+00

triacylglycerol lipase


:

Pssm-ID: 215432  Cd Length: 509  Bit Score: 809.38  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755    8 ADIFHAKRRRFTCNTHTSTLIPTKPLSVSPARK------TNKEHLRNLENVL-------RTSSNSIDHIENVTSRQEKTT 74
Cdd:PLN02802   1 LHLFQARRASFRCQPSPLNPNSTAPPSASSASPaansaaTTRAHLANLEKLLqkpppepRTSSNSPASQVGPGVANEGTT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755   75 KNTSTSSLLGGLNLARIWP-QMKAAVDEMSPKNLKRLQRLLSKSsEERSPKSKLGSKWRELHGLNNWAGLLDPLDENLRR 153
Cdd:PLN02802  81 PNNQRKGLLNALNLSRFWPfARKAAAEEMSPRSLNRLQRLLSKS-EEPSPRGTIASRWRELHGENGWEGLLDPLDENLRR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  154 ELVRYGEFVQAAYHAFHSDP------EGSPRHVALPDGSFKVTKSLYATSSVRLPKWIDDVAPDlRWMTKQTSWVGYVAV 227
Cdd:PLN02802 160 ELVRYGEFVQAAYHAFHSNPamsaeaPGRPRHVALPDRSYRVTKSLFATSSVGLPKWADDVAPD-GWMTQRSSWVGYVAV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  228 CDDPREIRRMGRREIVIALRGTATLLEWSENFRPNLVSMPEPKPDQSDPTRPKVECGFNSLYTTGDQHAPSLAESLVGEI 307
Cdd:PLN02802 239 CDSPREIRRMGRRDIVIALRGTATCLEWAENLRAGLVPMPGDDDDAGDQEQPKVECGFLSLYKTAGAHVPSLSESVVGEV 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  308 SRLVELYAGEELSISVTGHSLGAAIALLAADDIAERVPHAPPVAVFSFGGPRVGNREFADRLDSKGVKVLRVVNSQDVVT 387
Cdd:PLN02802 319 RRLMEKYKGEELSITVTGHSLGAALALLVADELATCVPAAPPVAVFSFGGPRVGNRAFADRLNARGVKVLRVVNAQDVVT 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  388 KVPGIFADNDKQGqsrnngrspggimemvernnpWAYSHVGAELRVDMKMSPYLKPNADVACCHDLEAYLHLVDGFLASN 467
Cdd:PLN02802 399 RVPGIAPREELHK---------------------WAYAHVGAELRLDSKMSPYLRPDADVACCHDLEAYLHLVDGFLGSN 457

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|..
gi 18414755  468 CPFRANAKRSLRKLLDEQRSNVKVLYTGKSLRLNRTFHDNGDV----LPSPS 515
Cdd:PLN02802 458 CPFRANAKRSLLRLLNEQRSNVKKLYTSKARALGLNLERPGDAgsgcLPSPS 509
 
Name Accession Description Interval E-value
PLN02802 PLN02802
triacylglycerol lipase
 8-515 0e+00

triacylglycerol lipase


Pssm-ID: 215432  Cd Length: 509  Bit Score: 809.38  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755    8 ADIFHAKRRRFTCNTHTSTLIPTKPLSVSPARK------TNKEHLRNLENVL-------RTSSNSIDHIENVTSRQEKTT 74
Cdd:PLN02802   1 LHLFQARRASFRCQPSPLNPNSTAPPSASSASPaansaaTTRAHLANLEKLLqkpppepRTSSNSPASQVGPGVANEGTT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755   75 KNTSTSSLLGGLNLARIWP-QMKAAVDEMSPKNLKRLQRLLSKSsEERSPKSKLGSKWRELHGLNNWAGLLDPLDENLRR 153
Cdd:PLN02802  81 PNNQRKGLLNALNLSRFWPfARKAAAEEMSPRSLNRLQRLLSKS-EEPSPRGTIASRWRELHGENGWEGLLDPLDENLRR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  154 ELVRYGEFVQAAYHAFHSDP------EGSPRHVALPDGSFKVTKSLYATSSVRLPKWIDDVAPDlRWMTKQTSWVGYVAV 227
Cdd:PLN02802 160 ELVRYGEFVQAAYHAFHSNPamsaeaPGRPRHVALPDRSYRVTKSLFATSSVGLPKWADDVAPD-GWMTQRSSWVGYVAV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  228 CDDPREIRRMGRREIVIALRGTATLLEWSENFRPNLVSMPEPKPDQSDPTRPKVECGFNSLYTTGDQHAPSLAESLVGEI 307
Cdd:PLN02802 239 CDSPREIRRMGRRDIVIALRGTATCLEWAENLRAGLVPMPGDDDDAGDQEQPKVECGFLSLYKTAGAHVPSLSESVVGEV 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  308 SRLVELYAGEELSISVTGHSLGAAIALLAADDIAERVPHAPPVAVFSFGGPRVGNREFADRLDSKGVKVLRVVNSQDVVT 387
Cdd:PLN02802 319 RRLMEKYKGEELSITVTGHSLGAALALLVADELATCVPAAPPVAVFSFGGPRVGNRAFADRLNARGVKVLRVVNAQDVVT 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  388 KVPGIFADNDKQGqsrnngrspggimemvernnpWAYSHVGAELRVDMKMSPYLKPNADVACCHDLEAYLHLVDGFLASN 467
Cdd:PLN02802 399 RVPGIAPREELHK---------------------WAYAHVGAELRLDSKMSPYLRPDADVACCHDLEAYLHLVDGFLGSN 457

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|..
gi 18414755  468 CPFRANAKRSLRKLLDEQRSNVKVLYTGKSLRLNRTFHDNGDV----LPSPS 515
Cdd:PLN02802 458 CPFRANAKRSLLRLLNEQRSNVKKLYTSKARALGLNLERPGDAgsgcLPSPS 509
Lipase_3 cd00519
Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into ...
 151-461 1.89e-36

Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of becoming active at the lipid/water interface, although several examples of lipases have been identified that do not undergo interfacial activation . The active site of a lipase contains a catalytic triad consisting of Ser - His - Asp/Glu, but unlike most serine proteases, the active site is buried inside the structure. A "lid" or "flap" covers the active site, making it inaccessible to solvent and substrates. The lid opens during the process of interfacial activation, allowing the lipid substrate access to the active site.


Pssm-ID: 238287 [Multi-domain]  Cd Length: 229  Bit Score: 134.91  E-value: 1.89e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755 151 LRRELVRYGEFVQAAYHafhsdpegsprhVALPDGSFKVTKSLYATSSVRLPKWIDDvapdlrwMTKQTSWVGYVAVCDD 230
Cdd:cd00519   1 DYEKLKYYAKLAAAAYC------------VDANILAKAVVFADIALLNVFSPDKLLK-------TDKQYDTQGYVAVDHD 61

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755 231 preirrmgRREIVIALRGTATLLEWSENFRPNLVSMPEPKPDQsdptrPKVECGFNSLYTTGDQHAPSLAESLVGEisrl 310
Cdd:cd00519  62 --------RKTIVIAFRGTVSLADWLTDLDFSPVPLDPPLCSG-----GKVHSGFYSAYKSLYNQVLPELKSALKQ---- 124

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755 311 velyaGEELSISVTGHSLG-----------AAIallaaddiaervPHAPPVAVFSFGGPRVGNREFADRLDSKGVKVLRV 379
Cdd:cd00519 125 -----YPDYKIIVTGHSLGgalasllaldlRLR------------GPGSDVTVYTFGQPRVGNAAFAEYLESTKGRVYRV 187

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755 380 VNSQDVVTKVPGIFAdndkqgqsrnngrspggimemverNNPWAYSHVGAELRVDmkmspylkpnadvaccHDLEAYLHL 459
Cdd:cd00519 188 VHGNDIVPRLPPGSL------------------------TPPEGYTHVGTEVWID----------------HLPYFYIDA 227


                ..
gi 18414755 460 VD 461
Cdd:cd00519 228 LC 229
Lipase_3 pfam01764
Lipase (class 3);
243-393 2.90e-33

Lipase (class 3);


Pssm-ID: 396362 [Multi-domain]  Cd Length: 139  Bit Score: 123.14  E-value: 2.90e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755   243 VIALRGTATLLEWSENFRPNLVSMPEPKPDQsdptrPKVECGFNSLYTtgdqhapSLAESLVGEISRLVELYagEELSIS 322
Cdd:pfam01764   1 VVAFRGTNSILDWLTDFDFSLTPFKDFFLGG-----GKVHSGFLSAYT-------SVREQVLAELKRLLEKY--PDYSIV 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18414755   323 VTGHSLGAAIALLAADDIAERVP-HAPPVAVFSFGGPRVGNREFADRLDSKGVK-VLRVVNSQDVVTKVPGIF 393
Cdd:pfam01764  67 VTGHSLGGALASLAALDLVENGLrLSSRVTVVTFGQPRVGNLEFAKLHDSQGPKfSYRVVHQRDIVPRLPPIV 139
Lip2 COG3675
Predicted lipase [Lipid transport and metabolism];
238-462 1.56e-16

Predicted lipase [Lipid transport and metabolism];


Pssm-ID: 442891 [Multi-domain]  Cd Length: 266  Bit Score: 79.80  E-value: 1.56e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755 238 GRREIVIALRGTATLLEWSENFRPNLVSMPEpkpdqsDPTRPKVECGFNSLYTtgdqhapSLAESLVGEisrLVELYAGE 317
Cdd:COG3675  25 SDDEVIVAFRGTESLTDWLTNLNAAQVPYPF------AKTGGKVHRGFYRALQ-------SLRELLEDA---LRPLSPGK 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755 318 ELSisVTGHSLGaAIALLAADDIAERVPHAPPVAVFSFGGPRVGNREFADRLDSKGVKVLRVVNSQDVVTKVPgifadnd 397
Cdd:COG3675  89 RLY--VTGHSLG-GALATLAAADLERNYIFPVRGLYTFGQPRVGDRSFAKYYNLHVPNSYRIVNNNDIVPLLP------- 158

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18414755 398 kqgqsrnngrsPGgimemvernnPWAYSHVGaelrvdmKMSPYLKPNADVACCHDLEAYLHLVDG 462
Cdd:COG3675 159 -----------PV----------WMGYDHVG-------KLLWLDSLRKDMLTDHSMDNYIHHTDL 195
 
Name Accession Description Interval E-value
PLN02802 PLN02802
triacylglycerol lipase
 8-515 0e+00

triacylglycerol lipase


Pssm-ID: 215432  Cd Length: 509  Bit Score: 809.38  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755    8 ADIFHAKRRRFTCNTHTSTLIPTKPLSVSPARK------TNKEHLRNLENVL-------RTSSNSIDHIENVTSRQEKTT 74
Cdd:PLN02802   1 LHLFQARRASFRCQPSPLNPNSTAPPSASSASPaansaaTTRAHLANLEKLLqkpppepRTSSNSPASQVGPGVANEGTT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755   75 KNTSTSSLLGGLNLARIWP-QMKAAVDEMSPKNLKRLQRLLSKSsEERSPKSKLGSKWRELHGLNNWAGLLDPLDENLRR 153
Cdd:PLN02802  81 PNNQRKGLLNALNLSRFWPfARKAAAEEMSPRSLNRLQRLLSKS-EEPSPRGTIASRWRELHGENGWEGLLDPLDENLRR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  154 ELVRYGEFVQAAYHAFHSDP------EGSPRHVALPDGSFKVTKSLYATSSVRLPKWIDDVAPDlRWMTKQTSWVGYVAV 227
Cdd:PLN02802 160 ELVRYGEFVQAAYHAFHSNPamsaeaPGRPRHVALPDRSYRVTKSLFATSSVGLPKWADDVAPD-GWMTQRSSWVGYVAV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  228 CDDPREIRRMGRREIVIALRGTATLLEWSENFRPNLVSMPEPKPDQSDPTRPKVECGFNSLYTTGDQHAPSLAESLVGEI 307
Cdd:PLN02802 239 CDSPREIRRMGRRDIVIALRGTATCLEWAENLRAGLVPMPGDDDDAGDQEQPKVECGFLSLYKTAGAHVPSLSESVVGEV 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  308 SRLVELYAGEELSISVTGHSLGAAIALLAADDIAERVPHAPPVAVFSFGGPRVGNREFADRLDSKGVKVLRVVNSQDVVT 387
Cdd:PLN02802 319 RRLMEKYKGEELSITVTGHSLGAALALLVADELATCVPAAPPVAVFSFGGPRVGNRAFADRLNARGVKVLRVVNAQDVVT 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  388 KVPGIFADNDKQGqsrnngrspggimemvernnpWAYSHVGAELRVDMKMSPYLKPNADVACCHDLEAYLHLVDGFLASN 467
Cdd:PLN02802 399 RVPGIAPREELHK---------------------WAYAHVGAELRLDSKMSPYLRPDADVACCHDLEAYLHLVDGFLGSN 457

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|..
gi 18414755  468 CPFRANAKRSLRKLLDEQRSNVKVLYTGKSLRLNRTFHDNGDV----LPSPS 515
Cdd:PLN02802 458 CPFRANAKRSLLRLLNEQRSNVKKLYTSKARALGLNLERPGDAgsgcLPSPS 509
PLN02408 PLN02408
phospholipase A1
 133-480 1.44e-130

phospholipase A1


Pssm-ID: 215228  Cd Length: 365  Bit Score: 384.19  E-value: 1.44e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  133 ELHGLNNWAGLLDPLDENLRRELVRYGEFVQAAYHAFHSDPeGSP-------------RHVALPDGSFKVTKSLYATSSV 199
Cdd:PLN02408   2 EYQGIRNWDGLLDPLDDNLRGEILRYGDFVEAAYKSFDFDP-SSPtyatcrfpkstllERSGLPNTGYRLTKHLRATSGI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  200 RLPKWIDDvAPDlrWMTKQTSWVGYVAVCDDPREIRRMGRREIVIALRGTATLLEWSENFRPNLVSMPEPKPDQSDP--- 276
Cdd:PLN02408  81 QLPRWIEK-APS--WVATQSSWIGYVAVCQDKEEIARLGRRDVVIAFRGTATCLEWLENLRATLTRLPNAPTDMNGSgdg 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  277 TRPKVECGFNSLYTTGDQHAPSLAESLVGEISRLVELYAGEELSISVTGHSLGAAIALLAADDIAERVPHAPPVAVFSFG 356
Cdd:PLN02408 158 SGPMVESGFLSLYTSGTAMGPSLQEMVREEIARLLQSYGDEPLSLTITGHSLGAALATLTAYDIKTTFKRAPMVTVISFG 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  357 GPRVGNREFADRLDSKGVKVLRVVNSQDVVTKVPGIFADNDKQ---GQSRNNGRSPGGIMEMVErNNPWAYSHVGAELRV 433
Cdd:PLN02408 238 GPRVGNRSFRRQLEKQGTKVLRIVNSDDVITKVPGFVIDGENDvakKRDVNVAGLPSWIQKRVE-DTQWVYAEVGRELRL 316

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 18414755  434 DMKMSPYLKPNaDVACCHDLEAYLHLVDGFLASNCPFRANAKRSLRK 480
Cdd:PLN02408 317 SSKDSPYLNSI-NVATCHDLKTYLHLVNGFVSSTCPFRATAKRVLGR 362
PLN02761 PLN02761
lipase class 3 family protein
 73-463 3.33e-96

lipase class 3 family protein


Pssm-ID: 215406 [Multi-domain]  Cd Length: 527  Bit Score: 301.58  E-value: 3.33e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755   73 TTKNTSTSSLLgglnlariwPQMKAAVDEMSPKNLKRLQRllsKSSEERSPKSKLGSKWRELHGLNNWAGLLDPLDENLR 152
Cdd:PLN02761  45 SSSCTSISSST---------TQQKQSNKQTHVSDNKREEE---PEEELEEKEVSLREIWREVQGCNNWEGLLDPMNNHLR 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  153 RELVRYGEFVQAAYHAFHSDPE----GS----PRHVAL-----PDGSFKVTKSLYATSSVRLPKWIDDVAPDLRWmTKQT 219
Cdd:PLN02761 113 REIIRYGEFAQACYDSFDFDPHskycGSckyhPSDFFQnldlhLHKGYTITRYLYATSNINLPNFFQKSKLSSIW-SQHA 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  220 SWVGYVAVCDDPREIRRMGRREIVIALRGTATLLEWSENFRPNLVsmpePKPDQSDPTrPKVECGFNSLYTTGDQHAP-- 297
Cdd:PLN02761 192 NWMGYVAVATDEEEVKRLGRRDIVIAWRGTVTYLEWIYDLKDILC----SANFGDDPS-IKIELGFHDLYTKKEDSCKfs 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  298 --SLAESLVGEISRLVELYA----GEELSISVTGHSLGAAIALLAADDIAE-RVPHAP------PVAVFSFGGPRVGNRE 364
Cdd:PLN02761 267 sfSAREQVLAEVKRLVEYYGteeeGHEISITVTGHSLGASLALVSAYDIAElNLNHVPennykiPITVFSFSGPRVGNLR 346

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  365 FADRLDSKGVKVLRVVNSQDVVTKVPGIFADNDKQGQsrnngrspggimEMVERNN--PWAYSHVGAELRVDMKMSPYLK 442
Cdd:PLN02761 347 FKERCDELGVKVLRVVNVHDKVPSVPGIFTNEKFQFQ------------KYVEEKTsfPWSYAHVGVELALDHKKSPFLK 414

                        410       420
                 ....*....|....*....|.
gi 18414755  443 PNADVACCHDLEAYLHLVDGF 463
Cdd:PLN02761 415 PTKDLGCAHNLEALLHLVDGY 435
PLN03037 PLN03037
lipase class 3 family protein; Provisional
 27-478 5.88e-91

lipase class 3 family protein; Provisional


Pssm-ID: 215547  Cd Length: 525  Bit Score: 287.62  E-value: 5.88e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755   27 LIPTKPLSVSPARKTNKEHLRNLENVLRT-----SSNSIDHIENVTSRQEKttKNTSTSSLLGGLNlariwPQMKAAVDE 101
Cdd:PLN03037   4 ALVKTPVTSRKLRRRKTKRVWKLKLAWKAikkavKSHLKKHLLHMKCRKEE--KQLSQVSDGGQLQ-----AERIKKISN 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  102 MSPKNLKRLQRLLSKSSE----------ERSPKSKLGSKWRELHGLNNWAGLLDPLDENLRRELVRYGEFVQAAYHAFHS 171
Cdd:PLN03037  77 HSTKSLAFLLQLPYTADDfidrgdlmtpTRSPRENISKMWREIHGSNNWENLLDPLHPWLRREVVKYGEFVEATYDAFDF 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  172 DPE----GSPRH--------VALPDGSFKVTKSLYATSSVRLPKWIDDVAPDLRWmTKQTSWVGYVAVCDDpREIRRMGR 239
Cdd:PLN03037 157 DPLsefcGSCRYnrhklfeeLGLTKHGYKVTKYIYAMSHVDVPQWFLRSATGETW-SKDSNWMGFVAVSGD-RESQRIGR 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  240 REIVIALRGTATLLEWSENFRPNLVSMPEPKPDQSdpTRPKVECGFNSLYTTGDQ----HAPSLAESLVGEISRLVELYA 315
Cdd:PLN03037 235 RDIVVAWRGTVAPTEWFMDLRTSLEPFDCDGDHGK--NVVKVQSGFLSIYKSKSEltryNKLSASEQVMEEVKRLVNFFK 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  316 --GEELSISVTGHSLGAAIALLAADDIAERVPHAPPVAVFSFGGPRVGNREFADRLDSKGVKVLRVVNSQDVVTKVPGIF 393
Cdd:PLN03037 313 drGEEVSLTITGHSLGGALALLNAYEAARSVPALSNISVISFGAPRVGNLAFKEKLNELGVKVLRVVNKQDIVPKLPGII 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  394 ADndkqgqsrnngRSPGGIMEMVERNNpWAYSHVGAELRVDMKMSPYLKPNADVACCHDLEAYLHLVDGFLASNCPFRAN 473
Cdd:PLN03037 393 FN-----------KILNKLNPITSRLN-WVYRHVGTQLKLDMFSSPYLKRESDLGGAHNLEVYLHLLDGFHGKKLGFRWN 460


                 ....*
gi 18414755  474 AKRSL 478
Cdd:PLN03037 461 ARRDL 465
PLN02310 PLN02310
triacylglycerol lipase
 121-478 4.51e-88

triacylglycerol lipase


Pssm-ID: 215176  Cd Length: 405  Bit Score: 276.48  E-value: 4.51e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  121 RSPKSKLGSKWRELHGLNNWAGLLDPLDENLRRELVRYGEFVQAAYHAFHSDPE----GSPRH--------VALPDGSFK 188
Cdd:PLN02310   5 RYLEENMSNKWHEIHGSSNWEHLLDPLHPWLRREILKYGEFAQATYDAFDFDPLseycGSCRYnrhklfetLGLTKHGYK 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  189 VTKSLYATSSVRLPKWIDdvAPDLRWmTKQTSWVGYVAVCDDpREIRRMGRREIVIALRGTATLLEWSENFRPNLVSMpe 268
Cdd:PLN02310  85 VKKYIYALSHVDVPHWLK--RSQATW-SKDSNWMGYVAVSRD-EESQRIGRRDIMVAWRGTVAPSEWFLDLETKLEHI-- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  269 pkpdqsDPTRPKVECGFNSLYTTGDQ----HAPSLAESLVGEISRLVELYA--GEELSISVTGHSLGAAIALLAADDIAE 342
Cdd:PLN02310 159 ------DNTNVKVQEGFLKIYKSKDEstryNKLSASEQVMQEVKRLVNFYRgkGEEVSLTVTGHSLGGALALLNAYEAAT 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  343 RVPHAPpVAVFSFGGPRVGNREFADRLDSKGVKVLRVVNSQDVVTKVPGIFADNDKQGQSRNNGRSpggimemvernnpW 422
Cdd:PLN02310 233 TIPDLF-VSVISFGAPRVGNIAFKEKLNELGVKTLRVVVKQDKVPKLPGLLNKMLNKFHGLTGKLN-------------W 298

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 18414755  423 AYSHVGAELRVDMKMSPYLKPNADVACCHDLEAYLHLVDGFLASNCPFRANAKRSL 478
Cdd:PLN02310 299 VYRHVGTQLKLDAFSSPYLKRESDLSGCHNLELYLHLIDGFHSEDSKFRWNARRDL 354
PLN02753 PLN02753
triacylglycerol lipase
 66-463 1.27e-77

triacylglycerol lipase


Pssm-ID: 178354  Cd Length: 531  Bit Score: 253.10  E-value: 1.27e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755   66 VTSRQEKTTKNTSTSSLLGGLNLARIWPQmKAAVDE--------MSPKNLKRLQRllsKSSEERspksKLGSKWRELHGL 137
Cdd:PLN02753  42 VATRALSRTDESSLSAVISRLERERRERQ-GLLIDEaegagelwLTAEDIRRRDK---KTEEER----RLRDTWRKIQGE 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  138 NNWAGLLDPLDENLRRELVRYGEFVQAAYHAFHSDPE----GSPR--------HVALPDGSFKVTKSLYATSSVRLPKWI 205
Cdd:PLN02753 114 DDWAGLIDPMDPILRSELIRYGEMAQACYDAFDFDPAskycGTSRfsrldffdSLGMIDSGYEVARYLYATSNINLPNFF 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  206 DDVAPDLRWmTKQTSWVGYVAVCDDPREIRRMGRREIVIALRGTATLLEWSENFRPNLVSMPEPKPDQSDPTrPKVECGF 285
Cdd:PLN02753 194 SKSRWSKVW-SKNANWMGYVAVSDDETSRNRLGRRDIAIAWRGTVTKLEWIADLKDYLKPVSENKIRCPDPA-VKVESGF 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  286 NSLYTTGDQHAP----SLAESLVGEISRLVELYAGEE---LSISVTGHSLGAAIALLAADDIAE------RVPHAPPVAV 352
Cdd:PLN02753 272 LDLYTDKDTTCKfakfSAREQILTEVKRLVEEHGDDDdsdLSITVTGHSLGGALAILSAYDIAEmglnrsKKGKVIPVTV 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  353 FSFGGPRVGNREFADRLDSKGVKVLRVVNSQDVVTKVPGIFADNDKqgqsrnngrsPGGIMEMVErNNPWAYSHVGAELR 432
Cdd:PLN02753 352 LTYGGPRVGNVRFKDRMEELGVKVLRVVNVHDVVPKSPGLFLNESR----------PHALMKIAE-GLPWCYSHVGEELA 420

                        410       420       430
                 ....*....|....*....|....*....|.
gi 18414755  433 VDMKMSPYLKPNADVACCHDLEAYLHLVDGF 463
Cdd:PLN02753 421 LDHQNSPFLKPSVDLSTAHNLEAMLHLLDGY 451
PLN02719 PLN02719
triacylglycerol lipase
 114-463 3.59e-77

triacylglycerol lipase


Pssm-ID: 178321  Cd Length: 518  Bit Score: 251.55  E-value: 3.59e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  114 LSKSSEERSPKSKLGSKWRELHGLNNWAGLLDPLDENLRRELVRYGEFVQAAYHAFHSDP--------EGSPRH----VA 181
Cdd:PLN02719  75 IRRRDGEAKESKRLRDTWRKIQGEDDWAGLMDPMDPVLRSELIRYGEMAQACYDAFDFDPfsrycgscRFTRRHlfdsLG 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  182 LPDGSFKVTKSLYATSSVRLPKWIDDVAPDLRWmTKQTSWVGYVAVCDDPREIR-RMGRREIVIALRGTATLLEWSENFR 260
Cdd:PLN02719 155 IIDSGYEVARYLYATSNINLPNFFSKSRWSKVW-SKNANWIGYVAVSDDDEATRcRLGRRDIAIAWRGTVTRLEWIADLK 233

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  261 PNLVSMPEPKPDQSDPTrPKVECGFNSLYTTGDQ----HAPSLAESLVGEISRLVELYA---GEELSISVTGHSLGAAIA 333
Cdd:PLN02719 234 DFLKPVSGNGFRCPDPA-VKAESGFLDLYTDKDTccnfSKFSAREQVLTEVKRLVERYGdeeGEELSITVTGHSLGGALA 312

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  334 LLAADDIAE------RVPHAPPVAVFSFGGPRVGNREFADRLDSKGVKVLRVVNSQDVVTKVPGIFAdndkqgqsrnNGR 407
Cdd:PLN02719 313 VLSAYDVAEmglnrtRKGKVIPVTAFTYGGPRVGNIRFKERIEELGVKVLRVVNEHDVVAKSPGLFL----------NER 382

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 18414755  408 SPGGIMEMVErNNPWAYSHVGAELRVDMKMSPYLKPNADVACCHDLEAYLHLVDGF 463
Cdd:PLN02719 383 APQALMKLAG-GLPWCYSHVGEMLPLDHQKSPFLKPTVDLSTAHNLEALLHLLDGY 437
PLN02571 PLN02571
triacylglycerol lipase
 130-478 3.50e-64

triacylglycerol lipase


Pssm-ID: 215309  Cd Length: 413  Bit Score: 214.37  E-value: 3.50e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  130 KWRELHGLNNWAGLLDPLDENLRRELVRYGEFVQAAYHAFHSDPE----GSPRH--------VALPDGS---FKVTKSLY 194
Cdd:PLN02571  21 RWRHLSGQNHWKGLLDPLDQDLREYIIHYGEMAQATYDTFNIQKAskfaGSSLYakkdffakVGLEKGNpykYKVTKFLY 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  195 ATSSVRLPK-WIDDVAPDLRWmTKQTSWVGYVAVCDDPREIrRMGRREIVIALRGTATLLEWSENFRPNLVSMPEPKPDQ 273
Cdd:PLN02571 101 ATSQIHVPEaFILKSLSREAW-SKESNWMGYVAVATDEGKA-LLGRRDIVIAWRGTVQTLEWVNDFEFNLVSASKIFGES 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  274 SDptRPKVECGFNSLYTTGDQHAP----SLAESLVGEISRLVELYAGEELSISVTGHSLGAAIALLAA--------DDIA 341
Cdd:PLN02571 179 ND--QPKVHQGWYSIYTSDDERSPfnktSARDQVLNEVGRLVEKYKDEEISITICGHSLGAALATLNAvdivangfNRSK 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  342 ERVPHAPPVAVFSFGGPRVGNREFADRLDS-KGVKVLRVVNSQDVVTKVPgifadndkqgqsrnngrspggimemvernn 420
Cdd:PLN02571 257 SRPNKSCPVTAFVFASPRVGDSDFKKLFSGlKDLRVLRVRNLPDVIPNYP------------------------------ 306

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 18414755  421 PWAYSHVGAELRVDMKMSPYLKPNADVACCHDLEAYLHLVDGFLASNCPFRANAKRSL 478
Cdd:PLN02571 307 LIGYSDVGEELPIDTRKSKYLKSPGNLSTWHNLEAYLHGVAGTQGSKGGFRLEVNRDI 364
PLN02454 PLN02454
triacylglycerol lipase
 131-478 8.28e-63

triacylglycerol lipase


Pssm-ID: 215249  Cd Length: 414  Bit Score: 210.85  E-value: 8.28e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  131 WRELHGLNNWAGLLDPLDENLRRELVRYGEFVQAAYHAFHSDPE----GSPRH--------VALPDGS-FKVTKSLYATS 197
Cdd:PLN02454   9 WPELLGSANWDGLLDPLDLSLRELILRCGDFCQATYDSFNNDQNskycGASRYgkssffdkVMLEAASdYEVAAFLYATA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  198 SVRLPKWIDDVAPDLRWMTKQTSWVGYVAVCDDPREiRRMGRREIVIALRGTATLLEWSENFRPNLVSMPEPKP------ 271
Cdd:PLN02454  89 RVSLPEAFLLHSMSRESWDRESNWIGYIAVTSDERT-KALGRREIYVAWRGTTRNYEWVDVLGAKLTSADPLLPgpeqdg 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  272 ---------DQSDPTRPKVECGFNSLYTTGDQHAP----SLAESLVGEISRLVELYAGEELSISVTGHSLGAAIALLAAD 338
Cdd:PLN02454 168 vvsgsssdsDDDDEKGPKVMLGWLTIYTSDDPRSPftklSARSQLLAKIKELLERYKDEKLSIVLTGHSLGASLATLAAF 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  339 DIAER--VPHAPPVAVFSFGGPRVGNREFADRLDS-KGVKVLRVVNSQDVVTkvpgifadndkqgqsrnngRSPGGIMem 415
Cdd:PLN02454 248 DIVENgvSGADIPVTAIVFGSPQVGNKEFNDRFKEhPNLKILHVRNTIDLIP-------------------HYPGGLL-- 306

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18414755  416 vernnpwAYSHVGAELRVDMKMSPYLKPNADVACCHDLEAYLHLVDGFLASNCPFRANAKRSL 478
Cdd:PLN02454 307 -------GYVNTGTELVIDTRKSPFLKDSKNPGDWHNLQAMLHVVAGWNGKKGEFELKVKRSL 362
PLN02324 PLN02324
triacylglycerol lipase
 127-478 4.49e-58

triacylglycerol lipase


Pssm-ID: 177958  Cd Length: 415  Bit Score: 198.32  E-value: 4.49e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  127 LGSKWRELHGLNNWAGLLDPLDENLRRELVRYGEFVQAAYHAFHSDPEGS-------------PRHVALPDGSF--KVTK 191
Cdd:PLN02324   5 IPKRWKVLSGQNKWKGLLDPLDPDLRRYIIHYGEMSQVGYDAFNWDRKSKyagdcyysknelfARTGFLKANPFryEVTK 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  192 SLYATSSVRLPKW--IDDVAPDLRwmTKQTSWVGYVAVCDDPREiRRMGRREIVIALRGTATLLEWSENFRPNLVSMPEP 269
Cdd:PLN02324  85 YIYATASIKLPICfiVKSLSKDAS--RVQTNWMGYIAVATDQGK-AMLGRRDIVVAWRGTLQPYEWANDFDFPLESAISV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  270 KPDQSDPTRPKVECGFNSLYTTGDQHAP----SLAESLVGEISRLVELYAGEELSISVTGHSLGAAIA---------LLA 336
Cdd:PLN02324 162 FPVTDPKDNPRIGSGWLDIYTASDSRSPydttSAQEQVQGELKRLLELYKNEEISITFTGHSLGAVMSvlsaadlvyGKK 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755  337 ADDIAERVPHAPPVAVFSFGGPRVGNREFADRLDS-KGVKVLRVVNSQDVVTKVPGIFadndkqgqsrnngrspggimem 415
Cdd:PLN02324 242 NKINISLQKKQVPITVFAFGSPRIGDHNFKNLVDSlQPLNILRIVNVPDVAPHYPLLL---------------------- 299

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18414755  416 vernnpwaYSHVGAELRVDMKMSPYLKPNADVACCHDLEAYLHLVDGFLASNCPFRANAKRSL 478
Cdd:PLN02324 300 --------YTEIGEVLEINTLNSTYLKRSLNFRNYHNLEAYLHGVAGMQDTQGEFKLEINRDI 354
Lipase_3 cd00519
Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into ...
 151-461 1.89e-36

Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of becoming active at the lipid/water interface, although several examples of lipases have been identified that do not undergo interfacial activation . The active site of a lipase contains a catalytic triad consisting of Ser - His - Asp/Glu, but unlike most serine proteases, the active site is buried inside the structure. A "lid" or "flap" covers the active site, making it inaccessible to solvent and substrates. The lid opens during the process of interfacial activation, allowing the lipid substrate access to the active site.


Pssm-ID: 238287 [Multi-domain]  Cd Length: 229  Bit Score: 134.91  E-value: 1.89e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755 151 LRRELVRYGEFVQAAYHafhsdpegsprhVALPDGSFKVTKSLYATSSVRLPKWIDDvapdlrwMTKQTSWVGYVAVCDD 230
Cdd:cd00519   1 DYEKLKYYAKLAAAAYC------------VDANILAKAVVFADIALLNVFSPDKLLK-------TDKQYDTQGYVAVDHD 61

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755 231 preirrmgRREIVIALRGTATLLEWSENFRPNLVSMPEPKPDQsdptrPKVECGFNSLYTTGDQHAPSLAESLVGEisrl 310
Cdd:cd00519  62 --------RKTIVIAFRGTVSLADWLTDLDFSPVPLDPPLCSG-----GKVHSGFYSAYKSLYNQVLPELKSALKQ---- 124

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755 311 velyaGEELSISVTGHSLG-----------AAIallaaddiaervPHAPPVAVFSFGGPRVGNREFADRLDSKGVKVLRV 379
Cdd:cd00519 125 -----YPDYKIIVTGHSLGgalasllaldlRLR------------GPGSDVTVYTFGQPRVGNAAFAEYLESTKGRVYRV 187

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755 380 VNSQDVVTKVPGIFAdndkqgqsrnngrspggimemverNNPWAYSHVGAELRVDmkmspylkpnadvaccHDLEAYLHL 459
Cdd:cd00519 188 VHGNDIVPRLPPGSL------------------------TPPEGYTHVGTEVWID----------------HLPYFYIDA 227


                ..
gi 18414755 460 VD 461
Cdd:cd00519 228 LC 229
Lipase_3 pfam01764
Lipase (class 3);
243-393 2.90e-33

Lipase (class 3);


Pssm-ID: 396362 [Multi-domain]  Cd Length: 139  Bit Score: 123.14  E-value: 2.90e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755   243 VIALRGTATLLEWSENFRPNLVSMPEPKPDQsdptrPKVECGFNSLYTtgdqhapSLAESLVGEISRLVELYagEELSIS 322
Cdd:pfam01764   1 VVAFRGTNSILDWLTDFDFSLTPFKDFFLGG-----GKVHSGFLSAYT-------SVREQVLAELKRLLEKY--PDYSIV 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18414755   323 VTGHSLGAAIALLAADDIAERVP-HAPPVAVFSFGGPRVGNREFADRLDSKGVK-VLRVVNSQDVVTKVPGIF 393
Cdd:pfam01764  67 VTGHSLGGALASLAALDLVENGLrLSSRVTVVTFGQPRVGNLEFAKLHDSQGPKfSYRVVHQRDIVPRLPPIV 139
Lip2 COG3675
Predicted lipase [Lipid transport and metabolism];
238-462 1.56e-16

Predicted lipase [Lipid transport and metabolism];


Pssm-ID: 442891 [Multi-domain]  Cd Length: 266  Bit Score: 79.80  E-value: 1.56e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755 238 GRREIVIALRGTATLLEWSENFRPNLVSMPEpkpdqsDPTRPKVECGFNSLYTtgdqhapSLAESLVGEisrLVELYAGE 317
Cdd:COG3675  25 SDDEVIVAFRGTESLTDWLTNLNAAQVPYPF------AKTGGKVHRGFYRALQ-------SLRELLEDA---LRPLSPGK 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755 318 ELSisVTGHSLGaAIALLAADDIAERVPHAPPVAVFSFGGPRVGNREFADRLDSKGVKVLRVVNSQDVVTKVPgifadnd 397
Cdd:COG3675  89 RLY--VTGHSLG-GALATLAAADLERNYIFPVRGLYTFGQPRVGDRSFAKYYNLHVPNSYRIVNNNDIVPLLP------- 158

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18414755 398 kqgqsrnngrsPGgimemvernnPWAYSHVGaelrvdmKMSPYLKPNADVACCHDLEAYLHLVDG 462
Cdd:COG3675 159 -----------PV----------WMGYDHVG-------KLLWLDSLRKDMLTDHSMDNYIHHTDL 195
Lipase cd00741
Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and ...
 283-464 1.10e-12

Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of becoming active at the lipid/water interface, although several examples of lipases have been identified that do not undergo interfacial activation . The active site of a lipase contains a catalytic triad consisting of Ser - His - Asp/Glu, but unlike most serine proteases, the active site is buried inside the structure. A "lid" or "flap" covers the active site, making it inaccessible to solvent and substrates. The lid opens during the process of interfacial activation, allowing the lipid substrate access to the active site.


Pssm-ID: 238382 [Multi-domain]  Cd Length: 153  Bit Score: 65.60  E-value: 1.10e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755 283 CGFNSLYTTGDQHAPSLAESLvgeisrlveLYAGEELSISVTGHSLG-----------AAIALLaaddiaervphaPPVA 351
Cdd:cd00741   1 KGFYKAARSLANLVLPLLKSA---------LAQYPDYKIHVTGHSLGgalaglagldlRGRGLG------------RLVR 59

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18414755 352 VFSFGGPRVGNREFA-DRLD-SKGVKVLRVVNSQDVVTKVPGifadndkqgqsrnngrspggimemvernNPWAYSHVGA 429
Cdd:cd00741  60 VYTFGPPRVGNAAFAeDRLDpSDALFVDRIVNDNDIVPRLPP----------------------------GGEGYPHGGA 111

                       170       180       190
                ....*....|....*....|....*....|....*
gi 18414755 430 ELRVDMKMSPYLKPNADVACCHDLEAYLHLVDGFL 464
Cdd:cd00741 112 EFYINGGKSQPGCCKNVLEAVDIDFGNIGLSGNGL 146
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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