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Conserved domains on  [gi|18416857|ref|NP_568274|]
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THUMP domain-containing protein [Arabidopsis thaliana]

Protein Classification

THUMP domain-containing protein( domain architecture ID 10185044)

THUMP domain-containing protein similar to human THUMP domain-containing protein 1 (THUMPD1) that functions as a tRNA-binding adapter to mediate NAT10-dependent tRNA acetylation

CATH:  3.30.2300.10
Gene Ontology:  GO:0006400|GO:0003723
PubMed:  11295541
SCOP:  4002010

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
THUMP_THUMPD1_like cd11717
THUMP domain-containing protein 1-like; This family contains THUMP domain-only proteins ...
225-359 3.64e-43

THUMP domain-containing protein 1-like; This family contains THUMP domain-only proteins including THUMP domain-containing protein 1 and Saccharomyces cerevisiae Tan1. Tan1 is non essential and has been shown to be required for the formation of the modified nucleoside N(4)-acetylcytidine (ac(4)C) in tRNA. To date, there is no functional information available about THUMPD1. The THUMP domain is named after thiouridine synthases, methylases and PSUSs. The domain consists of about 110 amino acid residues. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


:

Pssm-ID: 212586  Cd Length: 158  Bit Score: 147.34  E-value: 3.64e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18416857 225 GCNGLVFIQMKKrdgDPSPKEIVQHAMTSAAATKKHMSRFILRLLPIEVSCYPSEEEISRAIKPLVEQYFPIETEnPRKF 304
Cdd:cd11717  28 GVKNVVFIKTRP---PVDPVELVEKIFEDAASTKKKRTRFIQRLIPIDVTCKASLEEIEKLAKELLKKHFPTAEP-PKTF 103
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 18416857 305 AVLYGARANTGLDRMKIINTIAKSIPAPHKVDLSNPEMTIVVEIIKTVCLIGVVE 359
Cdd:cd11717 104 AVECKSRNNNKLSRDEVIKAVAELVPEIHKVDLKNPDKVILVEVIKNVCGISVVK 158
 
Name Accession Description Interval E-value
THUMP_THUMPD1_like cd11717
THUMP domain-containing protein 1-like; This family contains THUMP domain-only proteins ...
225-359 3.64e-43

THUMP domain-containing protein 1-like; This family contains THUMP domain-only proteins including THUMP domain-containing protein 1 and Saccharomyces cerevisiae Tan1. Tan1 is non essential and has been shown to be required for the formation of the modified nucleoside N(4)-acetylcytidine (ac(4)C) in tRNA. To date, there is no functional information available about THUMPD1. The THUMP domain is named after thiouridine synthases, methylases and PSUSs. The domain consists of about 110 amino acid residues. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 212586  Cd Length: 158  Bit Score: 147.34  E-value: 3.64e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18416857 225 GCNGLVFIQMKKrdgDPSPKEIVQHAMTSAAATKKHMSRFILRLLPIEVSCYPSEEEISRAIKPLVEQYFPIETEnPRKF 304
Cdd:cd11717  28 GVKNVVFIKTRP---PVDPVELVEKIFEDAASTKKKRTRFIQRLIPIDVTCKASLEEIEKLAKELLKKHFPTAEP-PKTF 103
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 18416857 305 AVLYGARANTGLDRMKIINTIAKSIPAPHKVDLSNPEMTIVVEIIKTVCLIGVVE 359
Cdd:cd11717 104 AVECKSRNNNKLSRDEVIKAVAELVPEIHKVDLKNPDKVILVEVIKNVCGISVVK 158
Tan1 COG1818
tRNA(Ser,Leu) C12 N-acetylase TAN1, contains THUMP domain [Translation, ribosomal structure ...
263-358 2.23e-12

tRNA(Ser,Leu) C12 N-acetylase TAN1, contains THUMP domain [Translation, ribosomal structure and biogenesis]; tRNA(Ser,Leu) C12 N-acetylase TAN1, contains THUMP domain is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441423  Cd Length: 162  Bit Score: 64.53  E-value: 2.23e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18416857 263 RFILRLLPIEVSCYPSEEEISRAIKPLVEQYFP-IETenprkFAVLYGARANTGLDRMKIINTIAKSIPAPHKVDLSNPE 341
Cdd:COG1818  64 RYILRVIPVDRVVKTDLEEIVEAAKELAKKKIPeGET-----FAVRCEKRGKSKLSSREVIRAIGEAIKRGAKVDLENPD 138
                        90
                ....*....|....*..
gi 18416857 342 MTIVVEIIKTVCLIGVV 358
Cdd:COG1818 139 WVVLVEILGDKAGISVL 155
THUMP smart00981
The THUMP domain is named after after thiouridine synthases, methylases and PSUSs; The THUMP ...
278-358 6.06e-06

The THUMP domain is named after after thiouridine synthases, methylases and PSUSs; The THUMP domain consists of about 110 amino acid residues. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterised RNA-binding domains. It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 214952 [Multi-domain]  Cd Length: 83  Bit Score: 43.80  E-value: 6.06e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18416857    278 SEEEISRAIKPLVEQYFPIEteNPRKFAV-LYGARANTGLDRMKIINTIAKSIPA---PHKVDLSNPEMTIVVEIIKTVC 353
Cdd:smart00981   1 DLEDLYETALELIRWEKIFK--EGKTFAVrAKRRGKNHEFTSLEVKRAIGDKLLEktgGRKVDLKNPDVVIRVELRKDKA 78

                   ....*
gi 18416857    354 LIGVV 358
Cdd:smart00981  79 YLSID 83
THUMP pfam02926
THUMP domain; The THUMP domain is named after after thiouridine synthases, methylases and ...
254-358 2.03e-05

THUMP domain; The THUMP domain is named after after thiouridine synthases, methylases and PSUSs. The THUMP domain consists of about 110 amino acid residues. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterized RNA-binding domains. It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 460749  Cd Length: 143  Bit Score: 43.97  E-value: 2.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18416857   254 AAATKKHMSRFILRLLPIEVSCYPSEEEISRAIKPLVEqyfPIETENPRKFAV-LYGARANTGLDRMKIINTIAKSI--P 330
Cdd:pfam02926  38 ELLKEALEKAPGIERFPVAETCEADLEDILELAKEIIK---DKFKKEGETFAVrVKRRGKNHEFTSLEINREVGKAIveK 114
                          90       100
                  ....*....|....*....|....*...
gi 18416857   331 APHKVDLSNPEMTIVVEIIKTVCLIGVV 358
Cdd:pfam02926 115 TGLKVDLENPDIVVHVEIIKDKAYISID 142
 
Name Accession Description Interval E-value
THUMP_THUMPD1_like cd11717
THUMP domain-containing protein 1-like; This family contains THUMP domain-only proteins ...
225-359 3.64e-43

THUMP domain-containing protein 1-like; This family contains THUMP domain-only proteins including THUMP domain-containing protein 1 and Saccharomyces cerevisiae Tan1. Tan1 is non essential and has been shown to be required for the formation of the modified nucleoside N(4)-acetylcytidine (ac(4)C) in tRNA. To date, there is no functional information available about THUMPD1. The THUMP domain is named after thiouridine synthases, methylases and PSUSs. The domain consists of about 110 amino acid residues. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 212586  Cd Length: 158  Bit Score: 147.34  E-value: 3.64e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18416857 225 GCNGLVFIQMKKrdgDPSPKEIVQHAMTSAAATKKHMSRFILRLLPIEVSCYPSEEEISRAIKPLVEQYFPIETEnPRKF 304
Cdd:cd11717  28 GVKNVVFIKTRP---PVDPVELVEKIFEDAASTKKKRTRFIQRLIPIDVTCKASLEEIEKLAKELLKKHFPTAEP-PKTF 103
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 18416857 305 AVLYGARANTGLDRMKIINTIAKSIPAPHKVDLSNPEMTIVVEIIKTVCLIGVVE 359
Cdd:cd11717 104 AVECKSRNNNKLSRDEVIKAVAELVPEIHKVDLKNPDKVILVEVIKNVCGISVVK 158
Tan1 COG1818
tRNA(Ser,Leu) C12 N-acetylase TAN1, contains THUMP domain [Translation, ribosomal structure ...
263-358 2.23e-12

tRNA(Ser,Leu) C12 N-acetylase TAN1, contains THUMP domain [Translation, ribosomal structure and biogenesis]; tRNA(Ser,Leu) C12 N-acetylase TAN1, contains THUMP domain is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441423  Cd Length: 162  Bit Score: 64.53  E-value: 2.23e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18416857 263 RFILRLLPIEVSCYPSEEEISRAIKPLVEQYFP-IETenprkFAVLYGARANTGLDRMKIINTIAKSIPAPHKVDLSNPE 341
Cdd:COG1818  64 RYILRVIPVDRVVKTDLEEIVEAAKELAKKKIPeGET-----FAVRCEKRGKSKLSSREVIRAIGEAIKRGAKVDLENPD 138
                        90
                ....*....|....*..
gi 18416857 342 MTIVVEIIKTVCLIGVV 358
Cdd:COG1818 139 WVVLVEILGDKAGISVL 155
THUMP smart00981
The THUMP domain is named after after thiouridine synthases, methylases and PSUSs; The THUMP ...
278-358 6.06e-06

The THUMP domain is named after after thiouridine synthases, methylases and PSUSs; The THUMP domain consists of about 110 amino acid residues. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterised RNA-binding domains. It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 214952 [Multi-domain]  Cd Length: 83  Bit Score: 43.80  E-value: 6.06e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18416857    278 SEEEISRAIKPLVEQYFPIEteNPRKFAV-LYGARANTGLDRMKIINTIAKSIPA---PHKVDLSNPEMTIVVEIIKTVC 353
Cdd:smart00981   1 DLEDLYETALELIRWEKIFK--EGKTFAVrAKRRGKNHEFTSLEVKRAIGDKLLEktgGRKVDLKNPDVVIRVELRKDKA 78

                   ....*
gi 18416857    354 LIGVV 358
Cdd:smart00981  79 YLSID 83
THUMP cd11688
THUMP domain, predicted to bind RNA; The THUMP domain is named after THioUridine synthases, ...
198-356 6.94e-06

THUMP domain, predicted to bind RNA; The THUMP domain is named after THioUridine synthases, RNA Methyltransferases and Pseudo-uridine synthases. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 212583  Cd Length: 148  Bit Score: 45.56  E-value: 6.94e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18416857 198 KSIDKLIEAELKELGDkSKRRFMKLDPGCNGLVFIqmkKRDGDPSPKEIVQhamtsaaatkkhMSRFILRLLPIEVSCYP 277
Cdd:cd11688   7 KGLEEILAAELYELLE-VRGFDAEIQVVPHGRVHF---KTDTDEAVYQLVM------------WSRLISRIMPPLGECKA 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18416857 278 SEEEISRAIKPLVEQYFPIETEnprKFAVLYGARANTGLDRMKIINTIAKSIPAPH--KVDLSNPEMTIVVEIIKTVCLI 355
Cdd:cd11688  71 DLEDLYETALEINEPEMGNEGA---KFAVRARRRNKTILNSQEIAMKVGDAIVDAFnpEVDLDNPDIVVNVEVHKEIASI 147

                .
gi 18416857 356 G 356
Cdd:cd11688 148 A 148
THUMP pfam02926
THUMP domain; The THUMP domain is named after after thiouridine synthases, methylases and ...
254-358 2.03e-05

THUMP domain; The THUMP domain is named after after thiouridine synthases, methylases and PSUSs. The THUMP domain consists of about 110 amino acid residues. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterized RNA-binding domains. It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 460749  Cd Length: 143  Bit Score: 43.97  E-value: 2.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18416857   254 AAATKKHMSRFILRLLPIEVSCYPSEEEISRAIKPLVEqyfPIETENPRKFAV-LYGARANTGLDRMKIINTIAKSI--P 330
Cdd:pfam02926  38 ELLKEALEKAPGIERFPVAETCEADLEDILELAKEIIK---DKFKKEGETFAVrVKRRGKNHEFTSLEINREVGKAIveK 114
                          90       100
                  ....*....|....*....|....*...
gi 18416857   331 APHKVDLSNPEMTIVVEIIKTVCLIGVV 358
Cdd:pfam02926 115 TGLKVDLENPDIVVHVEIIKDKAYISID 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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