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Conserved domains on  [gi|30686005|ref|NP_568338|]
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Transducin family protein / WD-40 repeat family protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10078037)

WD40 repeat domain-containing protein similar to Schizosaccharomyces pombe U3 small nucleolar RNA-associated protein 13 (UTP13) and Danio rerio transducin beta-like protein 3

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
67-614 2.42e-70

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 238.27  E-value: 2.42e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005  67 ALSPDDKLLFSAGHSRQIRVWDLETLKCIRSWKGHEGPVMGMACHASGGLLATAGADRKVLVWDVDGGFCTHYFRGHKGV 146
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 147 VSSILFHPDSNknILISGSDDATVRVWDLNAKntekKCLAIMEKHFSAVTSIALSEDGLTLFSAGRDKVVNLWDLHDYSC 226
Cdd:COG2319  81 VLSVAFSPDGR--LLASASADGTVRLWDLATG----LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 227 KATVAtyevleavttvssgtpfasfvasldqkkskkkesdsqatyfitvGERGVVRiwksegsiclyeqkssDITVSSDD 306
Cdd:COG2319 155 LRTLT--------------------------------------------GHSGAVT----------------SVAFSPDG 174

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 307 eeskrgftaaamlpsdhgllcvtadqqfffysvvenveetelvlskrlvgyneeiadmkflgdeeQFLAVATNLEEVRVY 386
Cdd:COG2319 175 -----------------------------------------------------------------KLLASGSDDGTVRLW 189

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 387 DVATMSCSYVLAGHKEVVLSLdtCVSSSGNvLIVTGSKDKTVRLWNATSKSCIGVGTGHNGDILAVAFAKKSfSFFVSGS 466
Cdd:COG2319 190 DLATGKLLRTLTGHTGAVRSV--AFSPDGK-LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDG-RLLASGS 265

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 467 GDRTLKVWSLDGisedseepinLKTRSVVAAHDKDINSVAVARNDSLVCTGSEDRTASIWRLPDLVHVVTLKGHKRRIFS 546
Cdd:COG2319 266 ADGTVRLWDLAT----------GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS 335

                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30686005 547 VEFSTVDQCVMTASGDKTVKIWAISDGSCLKTFEGHTSSVLRASFITDGTQFVSCGADGLLKLWNVNT 614
Cdd:COG2319 336 VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
Utp13 pfam08625
Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex ...
 675-806 1.39e-53

Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex that forms part of a stable particle subunit independent of the U3 small nucleolar ribonucleoprotein that is essential for the initial assembly steps of the 90S pre-ribosome. Pwp2 is capable of interacting directly with the 35 S pre-rRNA 5' end.


:

Pssm-ID: 462540  Cd Length: 139  Bit Score: 182.32  E-value: 1.39e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005   675 QELENAVLDAEYTKAIRLAFELCRPHKVFELFSGLCRKRDSDE------QIVKALQGLEKEEFRLLFEYVREWNTKPKLC 748
Cdd:pfam08625   2 QELQNLLRNKDYREAILLALTLNHPHRLLKLFKALLTSADDEGsitglkELDEVIKTLSDEQLEKLLKYIRDWNTNAKTS 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 30686005   749 HIAQFVLYKTFNILPPTEIVQVKGIGELLEGLIPYSQRHFSRIDRFVRSSFLLDYTLG 806
Cdd:pfam08625  82 HVAQRVLNALLKSYPPEELLELPGLKEILEALIPYTERHFSRLDRLVQESYLLDYTLQ 139
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 614-653 8.77e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


:

Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 8.77e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 30686005    614 TSECIATYDQHEDKVWALAVGKKTEMIATGGGDAVINLWH 653
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
67-614 2.42e-70

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 238.27  E-value: 2.42e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005  67 ALSPDDKLLFSAGHSRQIRVWDLETLKCIRSWKGHEGPVMGMACHASGGLLATAGADRKVLVWDVDGGFCTHYFRGHKGV 146
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 147 VSSILFHPDSNknILISGSDDATVRVWDLNAKntekKCLAIMEKHFSAVTSIALSEDGLTLFSAGRDKVVNLWDLHDYSC 226
Cdd:COG2319  81 VLSVAFSPDGR--LLASASADGTVRLWDLATG----LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 227 KATVAtyevleavttvssgtpfasfvasldqkkskkkesdsqatyfitvGERGVVRiwksegsiclyeqkssDITVSSDD 306
Cdd:COG2319 155 LRTLT--------------------------------------------GHSGAVT----------------SVAFSPDG 174

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 307 eeskrgftaaamlpsdhgllcvtadqqfffysvvenveetelvlskrlvgyneeiadmkflgdeeQFLAVATNLEEVRVY 386
Cdd:COG2319 175 -----------------------------------------------------------------KLLASGSDDGTVRLW 189

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 387 DVATMSCSYVLAGHKEVVLSLdtCVSSSGNvLIVTGSKDKTVRLWNATSKSCIGVGTGHNGDILAVAFAKKSfSFFVSGS 466
Cdd:COG2319 190 DLATGKLLRTLTGHTGAVRSV--AFSPDGK-LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDG-RLLASGS 265

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 467 GDRTLKVWSLDGisedseepinLKTRSVVAAHDKDINSVAVARNDSLVCTGSEDRTASIWRLPDLVHVVTLKGHKRRIFS 546
Cdd:COG2319 266 ADGTVRLWDLAT----------GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS 335

                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30686005 547 VEFSTVDQCVMTASGDKTVKIWAISDGSCLKTFEGHTSSVLRASFITDGTQFVSCGADGLLKLWNVNT 614
Cdd:COG2319 336 VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 350-652 2.12e-60

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 207.19  E-value: 2.12e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 350 LSKRLVGYNEEIADMKFLGDEEqFLAVATNLEEVRVYDVATMSCSYVLAGHKevvLSLDTCVSSSGNVLIVTGSKDKTVR 429
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGK-LLATGSGDGTIKVWDLETGELLRTLKGHT---GPVRDVAASADGTYLASGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 430 LWNATSKSCIGVGTGHNGDILAVAFAKKSfSFFVSGSGDRTLKVWSLDgisedseepiNLKTRSVVAAHDKDINSVAVAR 509
Cdd:cd00200  77 LWDLETGECVRTLTGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVE----------TGKCLTTLRGHTDWVNSVAFSP 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 510 NDSLVCTGSEDRTASIWRLPDLVHVVTLKGHKRRIFSVEFSTVDQCVMTASGDKTVKIWAISDGSCLKTFEGHTSSVLRA 589
Cdd:cd00200 146 DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV 225

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30686005 590 SFITDGTQFVSCGADGLLKLWNVNTSECIATYDQHEDKVWALAVGKKTEMIATGGGDAVINLW 652
Cdd:cd00200 226 AFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
Utp13 pfam08625
Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex ...
 675-806 1.39e-53

Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex that forms part of a stable particle subunit independent of the U3 small nucleolar ribonucleoprotein that is essential for the initial assembly steps of the 90S pre-ribosome. Pwp2 is capable of interacting directly with the 35 S pre-rRNA 5' end.


Pssm-ID: 462540  Cd Length: 139  Bit Score: 182.32  E-value: 1.39e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005   675 QELENAVLDAEYTKAIRLAFELCRPHKVFELFSGLCRKRDSDE------QIVKALQGLEKEEFRLLFEYVREWNTKPKLC 748
Cdd:pfam08625   2 QELQNLLRNKDYREAILLALTLNHPHRLLKLFKALLTSADDEGsitglkELDEVIKTLSDEQLEKLLKYIRDWNTNAKTS 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 30686005   749 HIAQFVLYKTFNILPPTEIVQVKGIGELLEGLIPYSQRHFSRIDRFVRSSFLLDYTLG 806
Cdd:pfam08625  82 HVAQRVLNALLKSYPPEELLELPGLKEILEALIPYTERHFSRLDRLVQESYLLDYTLQ 139
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 91-130 5.18e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 5.18e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 30686005     91 TLKCIRSWKGHEGPVMGMACHASGGLLATAGADRKVLVWD 130
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
134-174 1.37e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 1.37e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 30686005   134 GFCTHYFRGHKGVVSSILFHPDSNknILISGSDDATVRVWD 174
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK--LLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 100-234 4.88e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.89  E-value: 4.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005  100 GHEGPVMGMACHA-SGGLLATAGADRKVLVWDVDGGFCTH-------YFRGHKGVVSSILFHPdSNKNILISGSDDATVR 171
Cdd:PTZ00421  73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQnisdpivHLQGHTKKVGIVSFHP-SAMNVLASAGADMVVN 151

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30686005  172 VWDLN---AKNTeKKCLAimekhfSAVTSIALSEDGLTLFSAGRDKVVNLWDLHDYSCKATVATYE 234
Cdd:PTZ00421 152 VWDVErgkAVEV-IKCHS------DQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA 210
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 614-653 8.77e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 8.77e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 30686005    614 TSECIATYDQHEDKVWALAVGKKTEMIATGGGDAVINLWH 653
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
615-652 7.40e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 7.40e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 30686005   615 SECIATYDQHEDKVWALAVGKKTEMIATGGGDAVINLW 652
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
67-614 2.42e-70

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 238.27  E-value: 2.42e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005  67 ALSPDDKLLFSAGHSRQIRVWDLETLKCIRSWKGHEGPVMGMACHASGGLLATAGADRKVLVWDVDGGFCTHYFRGHKGV 146
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 147 VSSILFHPDSNknILISGSDDATVRVWDLNAKntekKCLAIMEKHFSAVTSIALSEDGLTLFSAGRDKVVNLWDLHDYSC 226
Cdd:COG2319  81 VLSVAFSPDGR--LLASASADGTVRLWDLATG----LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 227 KATVAtyevleavttvssgtpfasfvasldqkkskkkesdsqatyfitvGERGVVRiwksegsiclyeqkssDITVSSDD 306
Cdd:COG2319 155 LRTLT--------------------------------------------GHSGAVT----------------SVAFSPDG 174

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 307 eeskrgftaaamlpsdhgllcvtadqqfffysvvenveetelvlskrlvgyneeiadmkflgdeeQFLAVATNLEEVRVY 386
Cdd:COG2319 175 -----------------------------------------------------------------KLLASGSDDGTVRLW 189

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 387 DVATMSCSYVLAGHKEVVLSLdtCVSSSGNvLIVTGSKDKTVRLWNATSKSCIGVGTGHNGDILAVAFAKKSfSFFVSGS 466
Cdd:COG2319 190 DLATGKLLRTLTGHTGAVRSV--AFSPDGK-LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDG-RLLASGS 265

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 467 GDRTLKVWSLDGisedseepinLKTRSVVAAHDKDINSVAVARNDSLVCTGSEDRTASIWRLPDLVHVVTLKGHKRRIFS 546
Cdd:COG2319 266 ADGTVRLWDLAT----------GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS 335

                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30686005 547 VEFSTVDQCVMTASGDKTVKIWAISDGSCLKTFEGHTSSVLRASFITDGTQFVSCGADGLLKLWNVNT 614
Cdd:COG2319 336 VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
372-656 1.57e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 216.70  E-value: 1.57e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 372 QFLAVATNLEEVRVYDVATMSCSYVLAGHKEVVLSLdtCVSSSGNvLIVTGSKDKTVRLWNATSKSCIGVGTGHNGDILA 451
Cdd:COG2319  91 RLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSV--AFSPDGK-TLASGSADGTVRLWDLATGKLLRTLTGHSGAVTS 167

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 452 VAFAKKSfSFFVSGSGDRTLKVWSLDgisedseepiNLKTRSVVAAHDKDINSVAVARNDSLVCTGSEDRTASIWRLPDL 531
Cdd:COG2319 168 VAFSPDG-KLLASGSDDGTVRLWDLA----------TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG 236

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 532 VHVVTLKGHKRRIFSVEFSTVDQCVMTASGDKTVKIWAISDGSCLKTFEGHTSSVLRASFITDGTQFVSCGADGLLKLWN 611
Cdd:COG2319 237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD 316

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 30686005 612 VNTSECIATYDQHEDKVWALAVGKKTEMIATGGGDAVINLWHDST 656
Cdd:COG2319 317 LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT 361
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 350-652 2.12e-60

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 207.19  E-value: 2.12e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 350 LSKRLVGYNEEIADMKFLGDEEqFLAVATNLEEVRVYDVATMSCSYVLAGHKevvLSLDTCVSSSGNVLIVTGSKDKTVR 429
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGK-LLATGSGDGTIKVWDLETGELLRTLKGHT---GPVRDVAASADGTYLASGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 430 LWNATSKSCIGVGTGHNGDILAVAFAKKSfSFFVSGSGDRTLKVWSLDgisedseepiNLKTRSVVAAHDKDINSVAVAR 509
Cdd:cd00200  77 LWDLETGECVRTLTGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVE----------TGKCLTTLRGHTDWVNSVAFSP 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 510 NDSLVCTGSEDRTASIWRLPDLVHVVTLKGHKRRIFSVEFSTVDQCVMTASGDKTVKIWAISDGSCLKTFEGHTSSVLRA 589
Cdd:cd00200 146 DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV 225

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30686005 590 SFITDGTQFVSCGADGLLKLWNVNTSECIATYDQHEDKVWALAVGKKTEMIATGGGDAVINLW 652
Cdd:cd00200 226 AFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
27-478 9.36e-60

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 209.00  E-value: 9.36e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005  27 VSSDGSFIACACGDV-INIVDSTDSSVKSTIEGESDTLTALALSPDDKLLFSAGHSRQIRVWDLETLKCIRSWKGHEGPV 105
Cdd:COG2319  86 FSPDGRLLASASADGtVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAV 165

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 106 MGMACHASGGLLATAGADRKVLVWDVDGGFCTHYFRGHKGVVSSILFHPDSnkNILISGSDDATVRVWDLNAknteKKCL 185
Cdd:COG2319 166 TSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG--KLLASGSADGTVRLWDLAT----GKLL 239

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 186 AIMEKHFSAVTSIALSEDGLTLFSAGRDKVVNLWDLHDYSCKATVAtyevleavttvssgtpfasfvasldqkkskkkes 265
Cdd:COG2319 240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT---------------------------------- 285

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 266 dsqatyfitvGERGVVRiwksegsiclyeqkssDITVSSDDeeskrgftaaamlpsdhgllcvtadqqfffysvvenvee 345
Cdd:COG2319 286 ----------GHSGGVN----------------SVAFSPDG--------------------------------------- 300

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 346 telvlskrlvgyneeiadmkflgdeeQFLAVATNLEEVRVYDVATMSCSYVLAGHKEVVLSLdtCVSSSGNvLIVTGSKD 425
Cdd:COG2319 301 --------------------------KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGK-TLASGSDD 351

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|...
gi 30686005 426 KTVRLWNATSKSCIGVGTGHNGDILAVAFAKKSfSFFVSGSGDRTLKVWSLDG 478
Cdd:COG2319 352 GTVRLWDLATGELLRTLTGHTGAVTSVAFSPDG-RTLASGSADGTVRLWDLAT 403
Utp13 pfam08625
Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex ...
 675-806 1.39e-53

Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex that forms part of a stable particle subunit independent of the U3 small nucleolar ribonucleoprotein that is essential for the initial assembly steps of the 90S pre-ribosome. Pwp2 is capable of interacting directly with the 35 S pre-rRNA 5' end.


Pssm-ID: 462540  Cd Length: 139  Bit Score: 182.32  E-value: 1.39e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005   675 QELENAVLDAEYTKAIRLAFELCRPHKVFELFSGLCRKRDSDE------QIVKALQGLEKEEFRLLFEYVREWNTKPKLC 748
Cdd:pfam08625   2 QELQNLLRNKDYREAILLALTLNHPHRLLKLFKALLTSADDEGsitglkELDEVIKTLSDEQLEKLLKYIRDWNTNAKTS 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 30686005   749 HIAQFVLYKTFNILPPTEIVQVKGIGELLEGLIPYSQRHFSRIDRFVRSSFLLDYTLG 806
Cdd:pfam08625  82 HVAQRVLNALLKSYPPEELLELPGLKEILEALIPYTERHFSRLDRLVQESYLLDYTLQ 139
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 94-527 1.83e-50

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 179.45  E-value: 1.83e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005  94 CIRSWKGHEGPVMGMACHASGGLLATAGADRKVLVWDVDGGFCTHYFRGHKGVVSSILFHPDSNKniLISGSDDATVRVW 173
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY--LASGSSDKTIRLW 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 174 DLNAknteKKCLAIMEKHFSAVTSIALSEDGLTLFSAGRDKVVNLWDLHDYSCKATVatyevleavttvssgtpfasfva 253
Cdd:cd00200  79 DLET----GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL----------------------- 131

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 254 sldqkkskkkesdsqatyfitvgergvvriwksegsiclyeqkssditvssddeeskRGFTAAAMlpsdhgllCVtadqq 333
Cdd:cd00200 132 ---------------------------------------------------------RGHTDWVN--------SV----- 141

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 334 fffysvvenveetelvlskrlvgyneeiadmKFLGDeEQFLAVATNLEEVRVYDVATMSCSYVLAGHKEVVLSLdtCVSS 413
Cdd:cd00200 142 -------------------------------AFSPD-GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSV--AFSP 187

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 414 SGNVLIVTGSkDKTVRLWNATSKSCIGVGTGHNGDILAVAFAKKSfSFFVSGSGDRTLKVWSLDgisedseepiNLKTRS 493
Cdd:cd00200 188 DGEKLLSSSS-DGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG-YLLASGSEDGTIRVWDLR----------TGECVQ 255

                       410       420       430
                ....*....|....*....|....*....|....
gi 30686005 494 VVAAHDKDINSVAVARNDSLVCTGSEDRTASIWR 527
Cdd:cd00200 256 TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 53-475 1.35e-49

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 176.76  E-value: 1.35e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005  53 KSTIEGESDTLTALALSPDDKLLFSAGHSRQIRVWDLETLKCIRSWKGHEGPVMGMACHASGGLLATAGADRKVLVWDVD 132
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 133 GGFCTHYFRGHKGVVSSILFHPDSnkNILISGSDDATVRVWDLNakntEKKCLAIMEKHFSAVTSIALSEDGLTLFSAGR 212
Cdd:cd00200  82 TGECVRTLTGHTSYVSSVAFSPDG--RILSSSSRDKTIKVWDVE----TGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQ 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 213 DKVVNLWDLHDYSCKATvatyevleavttvssgtpfasfvasldqkkskkkesdsqatyfitvgergvvriwksegsicl 292
Cdd:cd00200 156 DGTIKLWDLRTGKCVAT--------------------------------------------------------------- 172

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 293 yeqkssditvssddeeskrgftaaamlpsdhgllcvtadqqfffysvvenveetelvlskrLVGYNEEIADMKFLGDEEQ 372
Cdd:cd00200 173 -------------------------------------------------------------LTGHTGEVNSVAFSPDGEK 191

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 373 FLAVATNLeEVRVYDVATMSCSYVLAGHKEVVLSLDTcvsSSGNVLIVTGSKDKTVRLWNATSKSCIGVGTGHNGDILAV 452
Cdd:cd00200 192 LLSSSSDG-TIKLWDLSTGKCLGTLRGHENGVNSVAF---SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSL 267

                       410       420
                ....*....|....*....|...
gi 30686005 453 AFAKKSfSFFVSGSGDRTLKVWS 475
Cdd:cd00200 268 AWSPDG-KRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 28-229 1.03e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 165.97  E-value: 1.03e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005  28 SSDGSFIACACGD-VINIVDSTDSSVKSTIEGESDTLTALALSPDDKLLFSAGHSRQIRVWDLETLKCIRSWKGHEGPVM 106
Cdd:cd00200  18 SPDGKLLATGSGDgTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVS 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 107 GMACHASGGLLATAGADRKVLVWDVDGGFCTHYFRGHKGVVSSILFHPDsnKNILISGSDDATVRVWDLNAknteKKCLA 186
Cdd:cd00200  98 SVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD--GTFVASSSQDGTIKLWDLRT----GKCVA 171

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 30686005 187 IMEKHFSAVTSIALSEDGLTLFSAGRDKVVNLWDLHDYSCKAT 229
Cdd:cd00200 172 TLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT 214
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 28-229 1.60e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 162.50  E-value: 1.60e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005  28 SSDGSFIACACGD-VINIVDSTDSSVKSTIEGESDTLTALALSPDDKLLFSAGHSRQIRVWDLETLKCIRSWKGHEGPVM 106
Cdd:cd00200  60 SADGTYLASGSSDkTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVN 139

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 107 GMACHASGGLLATAGADRKVLVWDVDGGFCTHYFRGHKGVVSSILFHPDSNKniLISGSDDATVRVWDLNAknteKKCLA 186
Cdd:cd00200 140 SVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEK--LLSSSSDGTIKLWDLST----GKCLG 213

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 30686005 187 IMEKHFSAVTSIALSEDGLTLFSAGRDKVVNLWDLHDYSCKAT 229
Cdd:cd00200 214 TLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT 256
WD40 COG2319
WD40 repeat [General function prediction only];
418-652 5.67e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.90  E-value: 5.67e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 418 LIVTGSKDKTVRLWNATSKSCIGVGTGHNGDILAVAFAKkSFSFFVSGSGDRTLKVWSLDGISEdseepinlktRSVVAA 497
Cdd:COG2319   8 ALAAASADLALALLAAALGALLLLLLGLAAAVASLAASP-DGARLAAGAGDLTLLLLDAAAGAL----------LATLLG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 498 HDKDINSVAVARNDSLVCTGSEDRTASIWRLPDLVHVVTLKGHKRRIFSVEFSTVDQCVMTASGDKTVKIWAISDGSCLK 577
Cdd:COG2319  77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR 156

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30686005 578 TFEGHTSSVLRASFITDGTQFVSCGADGLLKLWNVNTSECIATYDQHEDKVWALAVGKKTEMIATGGGDAVINLW 652
Cdd:COG2319 157 TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 27-220 8.43e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.91  E-value: 8.43e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005  27 VSSDGSFIACACGDvinivdstdssvkstiegesdtltalalspddkllfsaghsRQIRVWDLETLKCIRSWKGHEGPVM 106
Cdd:cd00200 143 FSPDGTFVASSSQD-----------------------------------------GTIKLWDLRTGKCVATLTGHTGEVN 181

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 107 GMACHASGGLLATAGADRKVLVWDVDGGFCTHYFRGHKGVVSSILFHPDSnkNILISGSDDATVRVWDLNAknteKKCLA 186
Cdd:cd00200 182 SVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG--YLLASGSEDGTIRVWDLRT----GECVQ 255

                       170       180       190
                ....*....|....*....|....*....|....
gi 30686005 187 IMEKHFSAVTSIALSEDGLTLFSAGRDKVVNLWD 220
Cdd:cd00200 256 TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 533-653 1.73e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.28  E-value: 1.73e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 533 HVVTLKGHKRRIFSVEFSTVDQCVMTASGDKTVKIWAISDGSCLKTFEGHTSSVLRASFITDGTQFVSCGADGLLKLWNV 612
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 30686005 613 NTSECIATYDQHEDKVWALAVGKKTEMIATGGGDAVINLWH 653
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD 121
WD40 COG2319
WD40 repeat [General function prediction only];
466-656 1.69e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.78  E-value: 1.69e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 466 SGDRTLKVWSLDGISEDSEEPINLKTRSVVAAHDKDINSVAVARNDSLVCTGSEDRTASIWRLPDLVHVVTLKGHKRRIF 545
Cdd:COG2319   3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 546 SVEFSTVDQCVMTASGDKTVKIWAISDGSCLKTFEGHTSSVLRASFITDGTQFVSCGADGLLKLWNVNTSECIATYDQHE 625
Cdd:COG2319  83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                       170       180       190
                ....*....|....*....|....*....|.
gi 30686005 626 DKVWALAVGKKTEMIATGGGDAVINLWHDST 656
Cdd:COG2319 163 GAVTSVAFSPDGKLLASGSDDGTVRLWDLAT 193
WD40 COG2319
WD40 repeat [General function prediction only];
506-656 3.45e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.66  E-value: 3.45e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 506 AVARNDSLVCTGSEDRTASIWRLPDLVHVVTLKGHKRRIFSVEFSTVDQCVMTASGDKTVKIWAISDGSCLKTFEGHTSS 585
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30686005 586 VLRASFITDGTQFVSCGADGLLKLWNVNTSECIATYDQHEDKVWALAVGKKTEMIATGGGDAVINLWHDST 656
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-130 5.66e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.46  E-value: 5.66e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005  11 RCSRSLKQFYGGGPFI-VSSDGSFIACACGD-VINIVDSTDSSVKSTIEGESDTLTALALSPDDKLLFSAGHSRQIRVWD 88
Cdd:cd00200 168 KCVATLTGHTGEVNSVaFSPDGEKLLSSSSDgTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD 247

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 30686005  89 LETLKCIRSWKGHEGPVMGMACHASGGLLATAGADRKVLVWD 130
Cdd:cd00200 248 LRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 91-130 5.18e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 5.18e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 30686005     91 TLKCIRSWKGHEGPVMGMACHASGGLLATAGADRKVLVWD 130
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 572-611 7.37e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 7.37e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 30686005    572 DGSCLKTFEGHTSSVLRASFITDGTQFVSCGADGLLKLWN 611
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 136-174 9.79e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.85  E-value: 9.79e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 30686005    136 CTHYFRGHKGVVSSILFHPDSNknILISGSDDATVRVWD 174
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGK--YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
134-174 1.37e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 1.37e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 30686005   134 GFCTHYFRGHKGVVSSILFHPDSNknILISGSDDATVRVWD 174
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK--LLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
573-611 9.27e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 9.27e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 30686005   573 GSCLKTFEGHTSSVLRASFITDGTQFVSCGADGLLKLWN 611
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
93-130 2.07e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 2.07e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 30686005    93 KCIRSWKGHEGPVMGMACHASGGLLATAGADRKVLVWD 130
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 100-234 4.88e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.89  E-value: 4.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005  100 GHEGPVMGMACHA-SGGLLATAGADRKVLVWDVDGGFCTH-------YFRGHKGVVSSILFHPdSNKNILISGSDDATVR 171
Cdd:PTZ00421  73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQnisdpivHLQGHTKKVGIVSFHP-SAMNVLASAGADMVVN 151

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30686005  172 VWDLN---AKNTeKKCLAimekhfSAVTSIALSEDGLTLFSAGRDKVVNLWDLHDYSCKATVATYE 234
Cdd:PTZ00421 152 VWDVErgkAVEV-IKCHS------DQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA 210
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 447-615 9.02e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 49.70  E-value: 9.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005  447 GDIL-------AVAFAKKSfSFFVSGSGDRTLKVWSLDGISEDSEE---PI-NLKTRSVVAAhdkdinsvaVARND---S 512
Cdd:PLN00181 477 GDLLnssnlvcAIGFDRDG-EFFATAGVNKKIKIFECESIIKDGRDihyPVvELASRSKLSG---------ICWNSyikS 546

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005  513 LVCTGSEDRTASIWRLPDLVHVVTLKGHKRRIFSVEFSTVDQCVM-TASGDKTVKIWAISDGSCLKTFE----------- 580
Cdd:PLN00181 547 QVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIKtkaniccvqfp 626

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30686005  581 --------------------------------GHTSSVLRASFItDGTQFVSCGADGLLKLWNVNTS 615
Cdd:PLN00181 627 sesgrslafgsadhkvyyydlrnpklplctmiGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSMS 692
PTZ00421 PTZ00421
coronin; Provisional
 58-230 1.50e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 48.35  E-value: 1.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005   58 GESDTLTALALSP-DDKLLFSAGHSRQIRVWDL-------ETLKCIRSWKGHEGPVMGMACHASG-GLLATAGADRKVLV 128
Cdd:PTZ00421  73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAmNVLASAGADMVVNV 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005  129 WDVDGGFCTHYFRGHKGVVSSILFHPDSnkNILISGSDDATVRVWDlnakNTEKKCLAIMEKHFSAVTSIAL----SEDG 204
Cdd:PTZ00421 153 WDVERGKAVEVIKCHSDQITSLEWNLDG--SLLCTTSKDKKLNIID----PRDGTIVSSVEAHASAKSQRCLwakrKDLI 226

                        170       180
                 ....*....|....*....|....*..
gi 30686005  205 LTL-FSAGRDKVVNLWDLHDYSCKATV 230
Cdd:PTZ00421 227 ITLgCSKSQQRQIMLWDTRKMASPYST 253
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 383-600 1.85e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.54  E-value: 1.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005  383 VRVYDVATMSCSYVLAGHKEVVLSLDtcVSSSGNVLIVTGSKDKTVRLWNATSKSCIG-VGTGHNgdILAVAFAKKSFSF 461
Cdd:PLN00181 557 VQVWDVARSQLVTEMKEHEKRVWSID--YSSADPTLLASGSDDGSVKLWSINQGVSIGtIKTKAN--ICCVQFPSESGRS 632

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005  462 FVSGSGDRTLKVWSLdgisEDSEEPInlktrSVVAAHDKDINSVAVARNDSLVcTGSEDRTASIWRLPDLVHVV------ 535
Cdd:PLN00181 633 LAFGSADHKVYYYDL----RNPKLPL-----CTMIGHSKTVSYVRFVDSSTLV-SSSTDNTLKLWDLSMSISGInetplh 702

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30686005  536 TLKGHKRRIFSVEFSTVDQCVMTASGDKTVKIWAISDGSCLKTFEGHTSSVLRASFITDGTQFVS 600
Cdd:PLN00181 703 SFMGHTNVKNFVGLSVSDGYIATGSETNEVFVYHKAFPMPVLSYKFKTIDPVSGLEVDDASQFIS 767
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 182-220 1.93e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 1.93e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 30686005    182 KKCLAIMEKHFSAVTSIALSEDGLTLFSAGRDKVVNLWD 220
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
182-220 2.46e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 2.46e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 30686005   182 KKCLAIMEKHFSAVTSIALSEDGLTLFSAGRDKVVNLWD 220
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 534-568 3.04e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 3.04e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 30686005    534 VVTLKGHKRRIFSVEFSTVDQCVMTASGDKTVKIW 568
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 390-432 3.59e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 3.59e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 30686005    390 TMSCSYVLAGHKEVVLSLdtCVSSSGNvLIVTGSKDKTVRLWN 432
Cdd:smart00320   1 SGELLKTLKGHTGPVTSV--AFSPDGK-YLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 510-644 4.96e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.81  E-value: 4.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005  510 NDSLVCTGSEDRTASIWRLPD-------LVHVVTLKGHKRRIFSVEFSTVDQCVMTASG-DKTVKIWAISDGSCLKTFEG 581
Cdd:PTZ00421  87 DPQKLFTASEDGTIMGWGIPEegltqniSDPIVHLQGHTKKVGIVSFHPSAMNVLASAGaDMVVNVWDVERGKAVEVIKC 166

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30686005  582 HTSSVLRASFITDGTQFVSCGADGLLKLWNVNTSECIATYDQHEDK-----VWAlavgKKTEMIATGG 644
Cdd:PTZ00421 167 HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAksqrcLWA----KRKDLIITLG 230
WD40 pfam00400
WD domain, G-beta repeat;
534-568 6.07e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 6.07e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 30686005   534 VVTLKGHKRRIFSVEFSTVDQCVMTASGDKTVKIW 568
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 435-475 1.09e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 1.09e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 30686005    435 SKSCIGVGTGHNGDILAVAFAKKSfSFFVSGSGDRTLKVWS 475
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 49-88 1.16e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 1.16e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 30686005     49 DSSVKSTIEGESDTLTALALSPDDKLLFSAGHSRQIRVWD 88
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
39-213 1.93e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.91  E-value: 1.93e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005  39 GDVINIVDSTDSSVKSTIEGESDTLTALALSPDDKLLF-SAGHSRQIRVWDLETLKCIRSWKGHEGPvMGMACHASGG-L 116
Cdd:COG3391  46 GAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYvANSGSGRVSVIDLATGKVVATIPVGGGP-RGLAVDPDGGrL 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 117 LATAGADRKVLVWDVDGGFCTHYFRGHKGvVSSILFHPDSNKnILISGSDDAT----VRVWDLNAKNTEKKclaImeKHF 192
Cdd:COG3391 125 YVADSGNGRVSVIDTATGKVVATIPVGAG-PHGIAVDPDGKR-LYVANSGSNTvsviVSVIDTATGKVVAT---I--PVG 197

                       170       180
                ....*....|....*....|.
gi 30686005 193 SAVTSIALSEDGLTLFSAGRD 213
Cdd:COG3391 198 GGPVGVAVSPDGRRLYVANRG 218
WD40 pfam00400
WD domain, G-beta repeat;
436-475 2.01e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 2.01e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 30686005   436 KSCIGVGTGHNGDILAVAFAKKSfSFFVSGSGDRTLKVWS 475
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
391-432 2.24e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 2.24e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 30686005   391 MSCSYVLAGHKEVVLSLdtCVSSSGNvLIVTGSKDKTVRLWN 432
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSL--AFSPDGK-LLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 60-221 2.57e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.69  E-value: 2.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005   60 SDTLTALALSPDDKLLFSAGHSRQIRVWDLETLkcIRSWKGHEGPVMGMACHAS-GGL---------LATAGADRKVLVW 129
Cdd:PLN00181 483 SNLVCAIGFDRDGEFFATAGVNKKIKIFECESI--IKDGRDIHYPVVELASRSKlSGIcwnsyiksqVASSNFEGVVQVW 560

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005  130 DVDGGFCTHYFRGHKGVVSSILFhPDSNKNILISGSDDATVRVWDLNA-------KNTEKKC------------------ 184
Cdd:PLN00181 561 DVARSQLVTEMKEHEKRVWSIDY-SSADPTLLASGSDDGSVKLWSINQgvsigtiKTKANICcvqfpsesgrslafgsad 639

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 30686005  185 --------------LAIMEKHFSAVTSIALSeDGLTLFSAGRDKVVNLWDL 221
Cdd:PLN00181 640 hkvyyydlrnpklpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDL 689
PTZ00420 PTZ00420
coronin; Provisional
 107-223 2.66e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.56  E-value: 2.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005  107 GMAChaSGGLLATAgadrkvlvWDVDGGFCTHYFRGH-----------KGVVSSIL---FHPdSNKNILISGSDDATVRV 172
Cdd:PTZ00420  33 GIAC--SSGFVAVP--------WEVEGGGLIGAIRLEnqmrkppviklKGHTSSILdlqFNP-CFSEILASGSEDLTIRV 101

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 30686005  173 WDL--NAKNTE--KKCLAIMEKHFSAVTSIALSE-DGLTLFSAGRDKVVNLWDLHD 223
Cdd:PTZ00420 102 WEIphNDESVKeiKDPQCILKGHKKKISIIDWNPmNYYIMCSSGFDSFVNIWDIEN 157
WD40 pfam00400
WD domain, G-beta repeat;
50-88 4.42e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 4.42e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 30686005    50 SSVKSTIEGESDTLTALALSPDDKLLFSAGHSRQIRVWD 88
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 614-653 8.77e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 8.77e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 30686005    614 TSECIATYDQHEDKVWALAVGKKTEMIATGGGDAVINLWH 653
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 67-208 1.24e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 41.80  E-value: 1.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005  67 ALSPDDKLLFSAGHSRQIRVWDLETLKcIRSWKGHEGPVMGMACHASGGLLAtAGADRKVLVWDVDGG----FCTHYFRG 142
Cdd:COG3386  14 VWDPDGRLYWVDIPGGRIHRYDPDGGA-VEVFAEPSGRPNGLAFDPDGRLLV-ADHGRGLVRFDPADGevtvLADEYGKP 91

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30686005 143 HK----GVVssilfhpDSNKNILIS--GSDDATVRVWDLNAKNTekkcLAIMEKHFSAVTSIALSEDGLTLF 208
Cdd:COG3386  92 LNrpndGVV-------DPDGRLYFTdmGEYLPTGALYRVDPDGS----LRVLADGLTFPNGIAFSPDGRTLY 152
WD40 pfam00400
WD domain, G-beta repeat;
490-526 2.45e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 2.45e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 30686005   490 KTRSVVAAHDKDINSVAVARNDSLVCTGSEDRTASIW 526
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
23-245 3.14e-03

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 40.66  E-value: 3.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005  23 GPFIVSSDGSFIACACGDvinivdsTDSSVKS-TIEGESDTLTAL-------------ALSPDDKLLFSA-GHSRQIRVW 87
Cdd:COG2706  48 SFLALSPDGRFLYAVNEV-------DDGGVSAfRIDPADGTLTLLntvssggaspchlSVDPDGRFLFVAnYGGGSVSVF 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005  88 DLE---TLKCIRSWKGHEG--PVM----GMACHA-----SGGLLATA--GADRkVLVWDVDGGfcTHYFRGHKGVVSS-- 149
Cdd:COG2706 121 PIDadgSLGEPVQVIQHEGsgPNPerqeGPHAHSvvfdpDGRFLYVPdlGTDR-IYVYRLDPA--TGKLPEPPEVSLPpg 197

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30686005 150 -----ILFHPDsNKNILISGSDDATVRVWDLNAKN---TEKKCLAIMEKHFSAVTS---IALSEDGLTLFSAGRDkvvnl 218
Cdd:COG2706 198 sgprhLAFHPN-GRFAYVINELDSTVSVYAYDAATgtlTLIQTVSTLPEDFTGENWaadIHISPDGRFLYVSNRG----- 271

                       250       260       270
                ....*....|....*....|....*....|...
gi 30686005 219 wdlHDysckaTVATYEV------LEAVTTVSSG 245
Cdd:COG2706 272 ---HN-----SIAVFAIdadggkLTLVGHVPTG 296
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 488-526 4.04e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 4.04e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 30686005    488 NLKTRSVVAAHDKDINSVAVARNDSLVCTGSEDRTASIW 526
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
615-652 7.40e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 7.40e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 30686005   615 SECIATYDQHEDKVWALAVGKKTEMIATGGGDAVINLW 652
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 63-134 7.43e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 39.52  E-value: 7.43e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30686005  63 LTALALSPDDKLLFSAGHSRQIRVWDLETLKCIRSWKGHEGPVMGM-ACHASGGLLATAGADRKVLVWDVDGG 134
Cdd:cd22857 226 IKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCFKGKCGGSIRSiARHPELPLIASCGLDRYLRIWDTETR 298
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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