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Conserved domains on  [gi|18422261|ref|NP_568614|]
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Thioredoxin superfamily protein [Arabidopsis thaliana]

Protein Classification

glutathione S-transferase; glutathione S-transferase omega family protein( domain architecture ID 11161787)

glutathione S-transferase catalyzes the conjugation of reduced glutathione to a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress| glutathione S-transferase (GST) omega family protein such as class-omega GSTs, which catalyze the GSH dependent reduction of protein disulfides, dehydroascorbate and monomethylarsonate, activities which are more characteristic of glutaredoxins than GSTs

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF953 pfam06110
Eukaryotic protein of unknown function (DUF953); This family consists of several hypothetical ...
 1-120 5.01e-52

Eukaryotic protein of unknown function (DUF953); This family consists of several hypothetical eukaryotic proteins of unknown function.


:

Pssm-ID: 399247  Cd Length: 119  Bit Score: 160.34  E-value: 5.01e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18422261     1 MTLKKVDANPSTLESslqelksdeTSRSKINFILFLADNDpTTGQSWCPDCVRAEPVIYKTLEEFPEEVKLIRAYAGDRP 80
Cdd:pfam06110   1 MALGFEEFNKSTKES---------ENGSKPIFILFSGSKD-TTGESWCPDCVRAEPVIYEALKEAPEDVHFIRVDVGDRP 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 18422261    81 TWRTPAHPWRVDSRFKLTGVPTLVRWDGDSvkgRLEDHQA 120
Cdd:pfam06110  71 YWRDPANPFRKDPRLKLTGVPTLLRWKGPQ---RLDGHQC 107
 
Name Accession Description Interval E-value
DUF953 pfam06110
Eukaryotic protein of unknown function (DUF953); This family consists of several hypothetical ...
 1-120 5.01e-52

Eukaryotic protein of unknown function (DUF953); This family consists of several hypothetical eukaryotic proteins of unknown function.


Pssm-ID: 399247  Cd Length: 119  Bit Score: 160.34  E-value: 5.01e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18422261     1 MTLKKVDANPSTLESslqelksdeTSRSKINFILFLADNDpTTGQSWCPDCVRAEPVIYKTLEEFPEEVKLIRAYAGDRP 80
Cdd:pfam06110   1 MALGFEEFNKSTKES---------ENGSKPIFILFSGSKD-TTGESWCPDCVRAEPVIYEALKEAPEDVHFIRVDVGDRP 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 18422261    81 TWRTPAHPWRVDSRFKLTGVPTLVRWDGDSvkgRLEDHQA 120
Cdd:pfam06110  71 YWRDPANPFRKDPRLKLTGVPTLLRWKGPQ---RLDGHQC 107
TRP14_like cd02952
Human TRX-related protein 14 (TRP14)-like family; composed of proteins similar to TRP14, a ...
 5-118 4.04e-45

Human TRX-related protein 14 (TRP14)-like family; composed of proteins similar to TRP14, a 14kD cytosolic protein that shows disulfide reductase activity in vitro with a different substrate specificity compared with another human cytosolic protein, TRX1. TRP14 catalyzes the reduction of small disulfide-containing peptides but does not reduce disulfides of ribonucleotide reductase, peroxiredoxin and methionine sulfoxide reductase, which are TRX1 substrates. TRP14 also plays a role in tumor necrosis factor (TNF)-alpha signaling pathways, distinct from that of TRX1. Its depletion promoted TNF-alpha induced activation of c-Jun N-terminal kinase and mitogen-activated protein kinases.


Pssm-ID: 239250  Cd Length: 119  Bit Score: 142.87  E-value: 4.04e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18422261   5 KVDANPSTLESSLQELKSDETsrsKINFILFLADNDPTtGQSWCPDCVRAEPVIYKTLEEFPEEVKLIRAYAGDRPTWRT 84
Cdd:cd02952   1 PLETAVRGYEEFLKLLKSHEG---KPIFILFYGDKDPD-GQSWCPDCVKAEPVVREALKAAPEDCVFIYCDVGDRPYWRD 76

                        90       100       110
                ....*....|....*....|....*....|....
gi 18422261  85 PAHPWRVDSRFKlTGVPTLVRWdgDSVKGRLEDH 118
Cdd:cd02952  77 PNNPFRTDPKLT-TGVPTLLRW--KTPQRLVEDE 107
 
Name Accession Description Interval E-value
DUF953 pfam06110
Eukaryotic protein of unknown function (DUF953); This family consists of several hypothetical ...
 1-120 5.01e-52

Eukaryotic protein of unknown function (DUF953); This family consists of several hypothetical eukaryotic proteins of unknown function.


Pssm-ID: 399247  Cd Length: 119  Bit Score: 160.34  E-value: 5.01e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18422261     1 MTLKKVDANPSTLESslqelksdeTSRSKINFILFLADNDpTTGQSWCPDCVRAEPVIYKTLEEFPEEVKLIRAYAGDRP 80
Cdd:pfam06110   1 MALGFEEFNKSTKES---------ENGSKPIFILFSGSKD-TTGESWCPDCVRAEPVIYEALKEAPEDVHFIRVDVGDRP 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 18422261    81 TWRTPAHPWRVDSRFKLTGVPTLVRWDGDSvkgRLEDHQA 120
Cdd:pfam06110  71 YWRDPANPFRKDPRLKLTGVPTLLRWKGPQ---RLDGHQC 107
TRP14_like cd02952
Human TRX-related protein 14 (TRP14)-like family; composed of proteins similar to TRP14, a ...
 5-118 4.04e-45

Human TRX-related protein 14 (TRP14)-like family; composed of proteins similar to TRP14, a 14kD cytosolic protein that shows disulfide reductase activity in vitro with a different substrate specificity compared with another human cytosolic protein, TRX1. TRP14 catalyzes the reduction of small disulfide-containing peptides but does not reduce disulfides of ribonucleotide reductase, peroxiredoxin and methionine sulfoxide reductase, which are TRX1 substrates. TRP14 also plays a role in tumor necrosis factor (TNF)-alpha signaling pathways, distinct from that of TRX1. Its depletion promoted TNF-alpha induced activation of c-Jun N-terminal kinase and mitogen-activated protein kinases.


Pssm-ID: 239250  Cd Length: 119  Bit Score: 142.87  E-value: 4.04e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18422261   5 KVDANPSTLESSLQELKSDETsrsKINFILFLADNDPTtGQSWCPDCVRAEPVIYKTLEEFPEEVKLIRAYAGDRPTWRT 84
Cdd:cd02952   1 PLETAVRGYEEFLKLLKSHEG---KPIFILFYGDKDPD-GQSWCPDCVKAEPVVREALKAAPEDCVFIYCDVGDRPYWRD 76

                        90       100       110
                ....*....|....*....|....*....|....
gi 18422261  85 PAHPWRVDSRFKlTGVPTLVRWdgDSVKGRLEDH 118
Cdd:cd02952  77 PNNPFRTDPKLT-TGVPTLLRW--KTPQRLVEDE 107
PGAP4-like_fungal cd22189
uncharacterized fungal proteins similar to Post-GPI attachment to proteins factor 4; This ...
 10-47 1.86e-03

uncharacterized fungal proteins similar to Post-GPI attachment to proteins factor 4; This subfamily contains uncharacterized fungal proteins with similarity to animal post-GPI attachment to proteins factor 4 (PGAP4), also known as post-GPI attachment to proteins GalNAc transferase 4 or transmembrane protein 246 (TMEM246). PGAP4 has been shown to be a Golgi-resident GPI-GalNAc transferase. Many eukaryotic proteins are anchored to the cell surface through glycolipid glycosylphosphatidylinositol (GPI). GPIs have a conserved core but exhibit diverse N-acetylgalactosamine (GalNAc) modifications. PGAP4 knockout cells lose GPI-GalNAc structures. PGAP4 is most likely involved in the initial steps of GPI-GalNAc biosynthesis. In contrast to other Golgi glycotransferases, it contains three transmembrane domains. Proteins from this subfamily contain the putative catalytic site of PGAP4 and may have similar activities.


Pssm-ID: 409190  Cd Length: 375  Bit Score: 36.76  E-value: 1.86e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 18422261  10 PSTLESSLQELKSDEtsRSKINFILFLADNDPTT----GQSW 47
Cdd:cd22189  91 DTTVGSLLDGLTPEE--RADIHLVVLIAHTDPTQhpayGEPW 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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