BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins; Elongin-C is also called elongin 15 kDa subunit, RNA polymerase II transcription factor SIII subunit C, SIII p15, or transcription elongation factor B polypeptide 1 (TCEB1). It is a component of SIII (also known as elongin), which is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. It forms a regulatory complex with subunit B or elongin-B (BC) that enhances the activity of the transcriptionally active subunit A. The BC complex also functions as an adaptor protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC (VHL) and the suppressors of cytokine signaling (SOCS) box ubiquitin ligase family. Elongin-C belongs to the BTB/POZ domain family; the domain is a common protein-protein interaction motif of about 100 amino acids.

                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424201  4 TVKLISMEGFEFVIDREAAMVSQTIRSMLTSPGGFSESKDGVVTFPDISTTILEKICQYFYWSLQYSR--GKETEFHIEP 81
Cdd:cd18321  1 YVKLISSDGHEFIVDREAAMVSGTIKAMLSGPGQFAENETNEVRFPEISSHILEKVCEYFYYKVRYTNssTEIPEFPIPP 80

                       90
               ....*....|....*
gi 18424201 82 ELTLELMMAANYLHT 96
Cdd:cd18321 81 EIALELLMAANFLDC 95

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins; Elongin-C is also called elongin 15 kDa subunit, RNA polymerase II transcription factor SIII subunit C, SIII p15, or transcription elongation factor B polypeptide 1 (TCEB1). It is a component of SIII (also known as elongin), which is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. It forms a regulatory complex with subunit B or elongin-B (BC) that enhances the activity of the transcriptionally active subunit A. The BC complex also functions as an adaptor protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC (VHL) and the suppressors of cytokine signaling (SOCS) box ubiquitin ligase family. Elongin-C belongs to the BTB/POZ domain family; the domain is a common protein-protein interaction motif of about 100 amino acids.

                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424201  4 TVKLISMEGFEFVIDREAAMVSQTIRSMLTSPGGFSESKDGVVTFPDISTTILEKICQYFYWSLQYSR--GKETEFHIEP 81
Cdd:cd18321  1 YVKLISSDGHEFIVDREAAMVSGTIKAMLSGPGQFAENETNEVRFPEISSHILEKVCEYFYYKVRYTNssTEIPEFPIPP 80

                       90
               ....*....|....*
gi 18424201 82 ELTLELMMAANYLHT 96
Cdd:cd18321 81 EIALELLMAANFLDC 95

Skp1 family, tetramerization domain;

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 18424201    5 VKLISMEGFEFVIDREAAMVSQTIRSMLTSPGgfseskDGVVTFPDISTTILEKICQY 62
Cdd:pfam03931  3 IVLQSSDGESFEVEEAVARKSKTIKHMIEDDG------DDPIPLPNVTSKILEKVIEY 54

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins; Elongin-C is also called elongin 15 kDa subunit, RNA polymerase II transcription factor SIII subunit C, SIII p15, or transcription elongation factor B polypeptide 1 (TCEB1). It is a component of SIII (also known as elongin), which is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. It forms a regulatory complex with subunit B or elongin-B (BC) that enhances the activity of the transcriptionally active subunit A. The BC complex also functions as an adaptor protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC (VHL) and the suppressors of cytokine signaling (SOCS) box ubiquitin ligase family. Elongin-C belongs to the BTB/POZ domain family; the domain is a common protein-protein interaction motif of about 100 amino acids.

                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424201  4 TVKLISMEGFEFVIDREAAMVSQTIRSMLTSPGGFSESKDGVVTFPDISTTILEKICQYFYWSLQYSR--GKETEFHIEP 81
Cdd:cd18321  1 YVKLISSDGHEFIVDREAAMVSGTIKAMLSGPGQFAENETNEVRFPEISSHILEKVCEYFYYKVRYTNssTEIPEFPIPP 80

                       90
               ....*....|....*
gi 18424201 82 ELTLELMMAANYLHT 96
Cdd:cd18321 81 EIALELLMAANFLDC 95

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins; SKP1 is also called cyclin-A/CDK2-associated protein p19 (p19A), organ of Corti protein 2 (OCP-2), organ of Corti protein II (OCP-II), RNA polymerase II elongation factor-like protein, transcription elongation factor B polypeptide 1-like, or p19skp1. It is an essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SKP1 serves as an adaptor protein that links the F-box protein to CUL1. SKP1 and CUL1 are invariant components of all SCF complexes, while F-box proteins are variable substrate binding modules that determine specificity. SKP1 belongs to the BTB/POZ domain family; the domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424201   4 TVKLISMEGFEFVIDREAAMVSQTIRSMLTSPGGfsesKDGVVTFPDISTTILEKI---CQY-----FYWSLQYSRGKET 75
Cdd:cd18322   1 KIKLQSSDGEIFEVDEEVARQSVTIKNMLEDLGY----DDDPIPLPNVTSKILKKViewCEHhkddpPPEIDLDSEKRTD 76

                        90       100
                ....*....|....*....|....*..
gi 18424201  76 EFH--------IEPELTLELMMAANYL 94
Cdd:cd18322  77 DIPewdaeflkVDQDTLFELILAANYL 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                       10        20        30        40        50        60        70
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18424201 22 AMVSQTIRSMLTSpgGFSESKDGVVTFPDISTTILEKICQYFYWSlqysrgketEFHIEPELTLELMMAANYL 94
Cdd:cd18186 21 AARSPYFRAMFSS--GMKESSSSEIELDDVSPEAFEALLDYIYTG---------ELELSEENVEELLAAADKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18424201  25 SQTIRSMLTSpgGFSESKDGVVTFPDISTTILEKICQYFYwslqysRGKETEFHIEPELTLELMMAAN 92
Cdd:cd18297  35 SDRFKSMLSS--GSTEAQTPVIEIPDIRYDIFQLMMQYLY------TGGVESLDVAQDDALELLRAAS 94