|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
10-439 |
7.43e-162 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 463.46 E-value: 7.43e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 10 TFAELGVREELVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALLeyvydsePKKGRRPdpa 89
Cdd:COG0513 3 SFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLD-------PSRPRAP--- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 90 fFACVLSPTRELAIQIAEQFEALGADISLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDHMsDTKGFSLKSLKYLV 169
Cdd:COG0513 73 -QALILAPTRELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLI-ERGALDLSGVETLV 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 170 LDEADRLLNEDFEKSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNPVKIEAASKYSTVDTLKQQYRFVAAKYKDC 249
Cdd:COG0513 151 LDEADRMLDMGFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLVDKRDKLE 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 250 YLVYILSEMPESTSMIFTRTCDGTRFLALVLRSLGFRAIPISGQMTQSKRLGALNKFKAGECNILVCTDVASRGLDIPSV 329
Cdd:COG0513 231 LLRRLLRDEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDV 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 330 DVVINYDIPTNSKDYIHRVGRTARAGRSGVGISLVNQYELEWYIQIEKLIGKKLPEYPAEEDEVLSLLERVAEAKKLSAM 409
Cdd:COG0513 311 SHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLLRAIEKLIGQKIEEEELPGFEPVEEKRLERLKPKIKEK 390
|
410 420 430
....*....|....*....|....*....|
gi 18424420 410 NMKESGGRKRRGEDDEESERFLGGNKDRGN 439
Cdd:COG0513 391 LKGKKAGRGGRPGPKGERKARRGKRRRRKR 420
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
10-224 |
2.71e-142 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 405.16 E-value: 2.71e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 10 TFAELGVREELVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALLEYVydsepkkgrrpdPA 89
Cdd:cd17954 1 TFKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLENP------------QR 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 90 FFACVLSPTRELAIQIAEQFEALGADISLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDHMSDTKGFSLKSLKYLV 169
Cdd:cd17954 69 FFALVLAPTRELAQQISEQFEALGSSIGLKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDHLENTKGFSLKSLKFLV 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 18424420 170 LDEADRLLNEDFEKSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNPVKIE 224
Cdd:cd17954 149 MDEADRLLNMDFEPEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNPVKIE 203
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
9-364 |
5.33e-95 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 293.00 E-value: 5.33e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 9 KTFAELGVREELVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALLEYvydsePKkgRRPDP 88
Cdd:PRK11192 1 TTFSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLDF-----PR--RKSGP 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 89 AFFaCVLSPTRELAIQIAEQFEALGADISLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDHMsDTKGFSLKSLKYL 168
Cdd:PRK11192 74 PRI-LILTPTRELAMQVADQARELAKHTHLDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQYI-KEENFDCRAVETL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 169 VLDEADRLLNEDFEKSLNQILEEIPLERKTFLFSATMT-KKVRKLQRACLRNPVKIEAASkySTVDTLK-QQYRFVA--A 244
Cdd:PRK11192 152 ILDEADRMLDMGFAQDIETIAAETRWRKQTLLFSATLEgDAVQDFAERLLNDPVEVEAEP--SRRERKKiHQWYYRAddL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 245 KYKDCYLVYILSEMPESTSMIFTRTCDGTRFLALVLRSLGFRAIPISGQMTQSKRLGALNKFKAGECNILVCTDVASRGL 324
Cdd:PRK11192 230 EHKTALLCHLLKQPEVTRSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDVAARGI 309
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 18424420 325 DIPSVDVVINYDIPTNSKDYIHRVGRTARAGRSGVGISLV 364
Cdd:PRK11192 310 DIDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGTAISLV 349
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
11-418 |
1.34e-91 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 285.16 E-value: 1.34e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 11 FAELGVREELVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALleyvydsepkkgrrpDPAF 90
Cdd:PRK11776 6 FSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKL---------------DVKR 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 91 FAC---VLSPTRELAIQIAEQFEALGADI-SLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDHMSdtKG-FSLKSL 165
Cdd:PRK11776 71 FRVqalVLCPTRELADQVAKEIRRLARFIpNIKVLTLCGGVPMGPQIDSLEHGAHIIVGTPGRILDHLR--KGtLDLDAL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 166 KYLVLDEADRLLNEDFEKSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNPVKIEAASKYSTvDTLKQQYRFVAAK 245
Cdd:PRK11776 149 NTLVLDEADRMLDMGFQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKVESTHDL-PAIEQRFYEVSPD 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 246 YKDCYLVYILSEM-PESTsMIFTRTCDGTRFLALVLRSLGFRAIPISGQMTQSKRLGALNKFKAGECNILVCTDVASRGL 324
Cdd:PRK11776 228 ERLPALQRLLLHHqPESC-VVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGL 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 325 DIPSVDVVINYDIPTNSKDYIHRVGRTARAGRSGVGISLVNQYELEWYIQIEKLIGKKLpeypaeEDEVLSLLERVAEAK 404
Cdd:PRK11776 307 DIKALEAVINYELARDPEVHVHRIGRTGRAGSKGLALSLVAPEEMQRANAIEDYLGRKL------NWEPLPSLSPLSGVP 380
|
410
....*....|....*
gi 18424420 405 KLSAM-NMKESGGRK 418
Cdd:PRK11776 381 LLPEMvTLCIDGGKK 395
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
11-224 |
2.95e-91 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 275.26 E-value: 2.95e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 11 FAELGVREELVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALLEyvydsepkkgrrpDP-A 89
Cdd:cd17955 1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRLSE-------------DPyG 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 90 FFACVLSPTRELAIQIAEQFEALGADISLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDHM--SDTKGFSLKSLKY 167
Cdd:cd17955 68 IFALVLTPTRELAYQIAEQFRALGAPLGLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLrsSDDTTKVLSRVKF 147
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 18424420 168 LVLDEADRLLNEDFEKSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNPVKIE 224
Cdd:cd17955 148 LVLDEADRLLTGSFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKPFFWE 204
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
20-224 |
2.01e-89 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 270.47 E-value: 2.01e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 20 LVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALLEyvydSEPKKGRRPdpafFACVLSPTR 99
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLP----EPKKKGRGP----QALVLAPTR 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 100 ELAIQIAEQFEALGADISLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDHMSDTKgFSLKSLKYLVLDEADRLLNE 179
Cdd:cd00268 73 ELAMQIAEVARKLGKGTGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERGK-LDLSNVKYLVLDEADRMLDM 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 18424420 180 DFEKSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNPVKIE 224
Cdd:cd00268 152 GFEEDVEKILSALPKDRQTLLFSATLPEEVKELAKKFLKNPVRIE 196
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
10-384 |
1.74e-81 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 258.97 E-value: 1.74e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 10 TFAELGVREELVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALLEyvyDSEPKKGRRPDPA 89
Cdd:PRK10590 2 SFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLIT---RQPHAKGRRPVRA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 90 FfacVLSPTRELAIQIAEQFEALGADISLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDhMSDTKGFSLKSLKYLV 169
Cdd:PRK10590 79 L---ILTPTRELAAQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLD-LEHQNAVKLDQVEILV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 170 LDEADRLLNEDFEKSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNPVKIEAASKYSTVDTLKQQYRFVAAKYKDC 249
Cdd:PRK10590 155 LDEADRMLDMGFIHDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTASEQVTQHVHFVDKKRKRE 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 250 YLVYILSEMPESTSMIFTRTCDGTRFLALVLRSLGFRAIPISGQMTQSKRLGALNKFKAGECNILVCTDVASRGLDIPSV 329
Cdd:PRK10590 235 LLSQMIGKGNWQQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEEL 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 18424420 330 DVVINYDIPTNSKDYIHRVGRTARAGRSGVGISLVNQYELEWYIQIEKLIGKKLP 384
Cdd:PRK10590 315 PHVVNYELPNVPEDYVHRIGRTGRAAATGEALSLVCVDEHKLLRDIEKLLKKEIP 369
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
6-395 |
2.54e-81 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 263.63 E-value: 2.54e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 6 EVVKTFAELGVREELVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALleyvyDSEPKKgrr 85
Cdd:PRK11634 3 EFETTFADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNL-----DPELKA--- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 86 pdPAFFacVLSPTRELAIQIAEQFEALGADI-SLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDHMSdtKG-FSLK 163
Cdd:PRK11634 75 --PQIL--VLAPTRELAVQVAEAMTDFSKHMrGVNVVALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLK--RGtLDLS 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 164 SLKYLVLDEADRLLNEDFEKSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNPVKIEAASKYSTVDTLKQQYRFVA 243
Cdd:PRK11634 149 KLSGLVLDEADEMLRMGFIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQEVRIQSSVTTRPDISQSYWTVW 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 244 AKYKDCYLVYILSEMPESTSMIFTRTCDGTRFLALVLRSLGFRAIPISGQMTQSKRLGALNKFKAGECNILVCTDVASRG 323
Cdd:PRK11634 229 GMRKNEALVRFLEAEDFDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARG 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18424420 324 LDIPSVDVVINYDIPTNSKDYIHRVGRTARAGRSGVGISLVNQYELEWYIQIEKLIGKKLPEYPAEEDEVLS 395
Cdd:PRK11634 309 LDVERISLVVNYDIPMDSESYVHRIGRTGRAGRAGRALLFVENRERRLLRNIERTMKLTIPEVELPNAELLG 380
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
3-399 |
9.68e-80 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 255.22 E-value: 9.68e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 3 EENEVVKTFAELGVREELVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALLEyvyDSEPKK 82
Cdd:PRK01297 81 EPQEGKTRFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQ---TPPPKE 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 83 GRRPDPAffACVLSPTRELAIQIAEQFEALGADISLRCAVLVGGIDRMQQTIALGKR-PHVIVATPGRLWDhMSDTKGFS 161
Cdd:PRK01297 158 RYMGEPR--ALIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEARfCDILVATPGRLLD-FNQRGEVH 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 162 LKSLKYLVLDEADRLLNEDFEKSLNQILEEIPL--ERKTFLFSATMTKKVRKLQRACLRNPVKIEAASKYSTVDTLKQQY 239
Cdd:PRK01297 235 LDMVEVMVLDEADRMLDMGFIPQVRQIIRQTPRkeERQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPENVASDTVEQHV 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 240 RFVAAKYKDCYLVYILSEMPESTSMIFTRTCDGTRFLALVLRSLGFRAIPISGQMTQSKRLGALNKFKAGECNILVCTDV 319
Cdd:PRK01297 315 YAVAGSDKYKLLYNLVTQNPWERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDV 394
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 320 ASRGLDIPSVDVVINYDIPTNSKDYIHRVGRTARAGRSGVGISLVNQYELEWYIQIEKLIGKKLP-EYPAeeDEVLSLLE 398
Cdd:PRK01297 395 AGRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISFAGEDDAFQLPEIEELLGRKIScEMPP--AELLKPVP 472
|
.
gi 18424420 399 R 399
Cdd:PRK01297 473 R 473
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
10-444 |
4.75e-79 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 256.03 E-value: 4.75e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 10 TFAELGVREELVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALLeyvydSEPK-KGRRP-D 87
Cdd:PRK04537 10 TFSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLL-----SRPAlADRKPeD 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 88 PAffACVLSPTRELAIQIAEQFEALGADISLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDHMSDTKGFSLKSLKY 167
Cdd:PRK04537 85 PR--ALILAPTRELAIQIHKDAVKFGADLGLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQHKVVSLHACEI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 168 LVLDEADRLLNEDFEKSLNQILEEIP--LERKTFLFSATMTKKVRKLQRACLRNPVKIEAASKYSTVDTLKQQYRFVAAK 245
Cdd:PRK04537 163 CVLDEADRMFDLGFIKDIRFLLRRMPerGTRQTLLFSATLSHRVLELAYEHMNEPEKLVVETETITAARVRQRIYFPADE 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 246 YKDCYLVYILSEMPESTSMIFTRTcdgTRFLALVLRSL---GFRAIPISGQMTQSKRLGALNKFKAGECNILVCTDVASR 322
Cdd:PRK04537 243 EKQTLLLGLLSRSEGARTMVFVNT---KAFVERVARTLerhGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAAR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 323 GLDIPSVDVVINYDIPTNSKDYIHRVGRTARAGRSGVGISLVNQYELEWYIQIEKLIGKKLPEYP--AEEDEVLSLLERV 400
Cdd:PRK04537 320 GLHIDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISFACERYAMSLPDIEAYIEQKIPVEPvtAELLTPLPRPPRV 399
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 18424420 401 AEAKKLSAMNMKESGG---RKRRGEDDEESERFLGGNKDRGNKERGG 444
Cdd:PRK04537 400 PVEGEEADDEAGDSVGtifREAREQRAAEEQRRGGGRSGPGGGSRSG 446
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
8-362 |
2.24e-77 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 250.85 E-value: 2.24e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 8 VKTFAELGVREELVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPIL-----QALLEYvydsepkk 82
Cdd:PTZ00110 129 VVSFEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAIvhinaQPLLRY-------- 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 83 GRRPdpafFACVLSPTRELAIQIAEQFEALGADISLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDHMsDTKGFSL 162
Cdd:PTZ00110 201 GDGP----IVLVLAPTRELAEQIREQCNKFGASSKIRNTVAYGGVPKRGQIYALRRGVEILIACPGRLIDFL-ESNVTNL 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 163 KSLKYLVLDEADRLLNEDFEKSLNQILEEIPLERKTFLFSATMTKKVRKLQRA-CLRNPVKIEAAS-KYSTVDTLKQQYR 240
Cdd:PTZ00110 276 RRVTYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVQSLARDlCKEEPVHVNVGSlDLTACHNIKQEVF 355
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 241 FVAAKYKDCYLVYILSEMPESTS--MIFTRTCDGTRFLALVLRSLGFRAIPISGQMTQSKRLGALNKFKAGECNILVCTD 318
Cdd:PTZ00110 356 VVEEHEKRGKLKMLLQRIMRDGDkiLIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFKTGKSPIMIATD 435
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 18424420 319 VASRGLDIPSVDVVINYDIPTNSKDYIHRVGRTARAGRSGVGIS 362
Cdd:PTZ00110 436 VASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYT 479
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
9-444 |
2.72e-72 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 234.10 E-value: 2.72e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 9 KTFAELGVREELVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFaipiLQALLEYVYDSEPKKGRRPD- 87
Cdd:PRK04837 8 QKFSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAF----LTATFHYLLSHPAPEDRKVNq 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 88 PAffACVLSPTRELAIQIAEQFEALGADISLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDHMSDtKGFSLKSLKY 167
Cdd:PRK04837 84 PR--ALIMAPTRELAVQIHADAEPLAQATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQ-NHINLGAIQV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 168 LVLDEADRLLNEDFEKSLNQILEEIP--LERKTFLFSATMTKKVRKLQRACLRNPVKIEAASKYSTVDTLKQQYRFVAAK 245
Cdd:PRK04837 161 VVLDEADRMFDLGFIKDIRWLFRRMPpaNQRLNMLFSATLSYRVRELAFEHMNNPEYVEVEPEQKTGHRIKEELFYPSNE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 246 YKDCYLVYILSE-MPEStSMIFTRTCDGTRFLALVLRSLGFRAIPISGQMTQSKRLGALNKFKAGECNILVCTDVASRGL 324
Cdd:PRK04837 241 EKMRLLQTLIEEeWPDR-AIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILEEFTRGDLDILVATDVAARGL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 325 DIPSVDVVINYDIPTNSKDYIHRVGRTARAGRSGVGISLV-NQYELEwYIQIEKLIGKKLP--EYPAEedevlSLLERVA 401
Cdd:PRK04837 320 HIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISLAcEEYALN-LPAIETYIGHSIPvsKYDSD-----ALLTDLP 393
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 18424420 402 EAKKLSAMNmkeSGGRKRRGeddeeserflGGNKDRGNKERGG 444
Cdd:PRK04837 394 KPLRLTRPR---TGNGPRRS----------GAPRNRRRRKRSG 423
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
20-223 |
1.41e-68 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 216.74 E-value: 1.41e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 20 LVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALLeyvydSEPKKGrrpdPAFFACVLSPTR 99
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLL-----YRPKKK----AATRVLVLVPTR 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 100 ELAIQIAEQFEALGADISLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDHMSDTKGFSLKSLKYLVLDEADRLLNE 179
Cdd:cd17947 72 ELAMQCFSVLQQLAQFTDITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDHLRNSPSFDLDSIEILVLDEADRMLEE 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 18424420 180 DFEKSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNPVKI 223
Cdd:cd17947 152 GFADELKEILRLCPRTRQTMLFSATMTDEVKDLAKLSLNKPVRV 195
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
5-394 |
2.40e-66 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 218.16 E-value: 2.40e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 5 NEVVKTFAELGVREELVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALleyvydsepkkgr 84
Cdd:PTZ00424 24 DEIVDSFDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLI------------- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 85 rpDPAFFAC---VLSPTRELAIQIAEQFEALGADISLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDhMSDTKGFS 161
Cdd:PTZ00424 91 --DYDLNACqalILAPTRELAQQIQKVVLALGDYLKVRCHACVGGTVVRDDINKLKAGVHMVVGTPGRVYD-MIDKRHLR 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 162 LKSLKYLVLDEADRLLNEDFEKSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNPVKIEAASKYSTVDTLKQQYRF 241
Cdd:PTZ00424 168 VDDLKLFILDEADEMLSRGFKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKDELTLEGIRQFYVA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 242 V-AAKYKDCYLVYILSEMPESTSMIFTRTCDGTRFLALVLRSLGFRAIPISGQMTQSKRLGALNKFKAGECNILVCTDVA 320
Cdd:PTZ00424 248 VeKEEWKFDTLCDLYETLTITQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLL 327
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18424420 321 SRGLDIPSVDVVINYDIPTNSKDYIHRVGRTARAGRSGVGISLVNQYELEWYIQIEKLIGKKLPEYPAEEDEVL 394
Cdd:PTZ00424 328 ARGIDVQQVSLVINYDLPASPENYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEIERHYNTQIEEMPMEVADYL 401
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
10-223 |
3.96e-60 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 195.22 E-value: 3.96e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 10 TFAELGVREELVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALleyvYDSEPKKGRRpdpa 89
Cdd:cd17959 2 GFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKL----KAHSPTVGAR---- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 90 ffACVLSPTRELAIQIAEQFEALGADISLRCAVLVGGiDRM-QQTIALGKRPHVIVATPGRLWDHMSDTkGFSLKSLKYL 168
Cdd:cd17959 74 --ALILSPTRELALQTLKVTKELGKFTDLRTALLVGG-DSLeEQFEALASNPDIIIATPGRLLHLLVEM-NLKLSSVEYV 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 18424420 169 VLDEADRLLNEDFEKSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNPVKI 223
Cdd:cd17959 150 VFDEADRLFEMGFAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVLI 204
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
235-364 |
1.38e-58 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 188.49 E-value: 1.38e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 235 LKQQYRFVAAKYKDCYL-VYILSEMPESTSMIFTRTCDGTRFLALVLRSLGFRAIPISGQMTQSKRLGALNKFKAGECNI 313
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLlLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 18424420 314 LVCTDVASRGLDIPSVDVVINYDIPTNSKDYIHRVGRTARAGRSGVGISLV 364
Cdd:cd18787 81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
20-221 |
3.58e-58 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 190.10 E-value: 3.58e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 20 LVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALLEYvydsepKKGRRPDPAFFACVLSPTR 99
Cdd:cd17961 5 LLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKA------KAESGEEQGTRALILVPTR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 100 ELAIQIAEQFEALGADIS--LRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDHMSDTKGFSLKSLKYLVLDEADRLL 177
Cdd:cd17961 79 ELAQQVSKVLEQLTAYCRkdVRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLSHLESGSLLLLSTLKYLVIDEADLVL 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 18424420 178 NEDFEKSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNPV 221
Cdd:cd17961 159 SYGYEEDLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPA 202
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
20-228 |
9.03e-58 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 190.14 E-value: 9.03e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 20 LVKACERLGWKNPSKIQAEALPFAL-EGKDVIGLAQTGSGKTGAFAIPILQALLEyvyDSEPKKGRRPDPAFFACVLSPT 98
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPAAIrDGKDVIGAAETGSGKTLAFGIPILERLLS---QKSSNGVGGKQKPLRALILTPT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 99 RELAIQIAEQFEALGADISLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDHMSDTKGF--SLKSLKYLVLDEADRL 176
Cdd:cd17946 78 RELAVQVKDHLKAIAKYTNIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIQEGNEHlaNLKSLRFLVLDEADRM 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18424420 177 LNEDFEKSLNQILEEIPLE-------RKTFLFSATMT-------KKVRKLQRACLRNPVKIEAASK 228
Cdd:cd17946 158 LEKGHFAELEKILELLNKDragkkrkRQTFVFSATLTldhqlplKLNSKKKKKKKEKKQKLELLIE 223
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
33-212 |
1.09e-57 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 187.45 E-value: 1.09e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 33 SKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALleyvydsepkkgRRPDPAFFACVLSPTRELAIQIAEQFEAL 112
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEAL------------DKLDNGPQALVLAPTRELAEQIYEELKKL 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 113 GADISLRCAVLVGGIDRMQQTIALgKRPHVIVATPGRLWDHMSDTKgfSLKSLKYLVLDEADRLLNEDFEKSLNQILEEI 192
Cdd:pfam00270 69 GKGLGLKVASLLGGDSRKEQLEKL-KGPDILVGTPGRLLDLLQERK--LLKNLKLLVLDEAHRLLDMGFGPDLEEILRRL 145
|
170 180
....*....|....*....|
gi 18424420 193 PLERKTFLFSATMTKKVRKL 212
Cdd:pfam00270 146 PKKRQILLLSATLPRNLEDL 165
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
10-219 |
1.10e-57 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 189.62 E-value: 1.10e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 10 TFAELGVREELVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALLEyvyDSEPKKGRRPDPA 89
Cdd:cd17967 1 SFEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLE---DGPPSVGRGRRKA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 90 F-FACVLSPTRELAIQIAEQFEALGADISLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDHMSDTKgFSLKSLKYL 168
Cdd:cd17967 78 YpSALILAPTRELAIQIYEEARKFSYRSGVRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIERGR-ISLSSIKFL 156
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 18424420 169 VLDEADRLLNEDFEKSLNQILEEIPL----ERKTFLFSATMTKKVRKLQRACLRN 219
Cdd:cd17967 157 VLDEADRMLDMGFEPQIRKIVEHPDMppkgERQTLMFSATFPREIQRLAADFLKN 211
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
22-223 |
1.42e-57 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 188.27 E-value: 1.42e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 22 KACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALleYVYDSEPKKGrrpdpaFFACVLSPTREL 101
Cdd:cd17941 3 KGLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKL--YRERWTPEDG------LGALIISPTREL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 102 AIQIAEQFEALGADISLRCAVLVGGIDRMQQTIALGKRpHVIVATPGRLWDHMSDTKGFSLKSLKYLVLDEADRLLNEDF 181
Cdd:cd17941 75 AMQIFEVLRKVGKYHSFSAGLIIGGKDVKEEKERINRM-NILVCTPGRLLQHMDETPGFDTSNLQMLVLDEADRILDMGF 153
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 18424420 182 EKSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNPVKI 223
Cdd:cd17941 154 KETLDAIVENLPKSRQTLLFSATQTKSVKDLARLSLKNPEYI 195
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
19-218 |
4.70e-56 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 184.71 E-value: 4.70e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 19 ELVKACERLGWKNPSKIQAEALPFALE-GKDVIGLAQTGSGKTGAFAIPILQALLEyvydsEPKKGRRPDPAffACVLSP 97
Cdd:cd17964 4 SLLKALTRMGFETMTPVQQKTLKPILStGDDVLARAKTGTGKTLAFLLPAIQSLLN-----TKPAGRRSGVS--ALIISP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 98 TRELAIQIAEQFEALGADI-SLRCAVLVGGIDRMQQTIALGK-RPHVIVATPGRLWDHMSDTK-GFSLKSLKYLVLDEAD 174
Cdd:cd17964 77 TRELALQIAAEAKKLLQGLrKLRVQSAVGGTSRRAELNRLRRgRPDILVATPGRLIDHLENPGvAKAFTDLDYLVLDEAD 156
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 18424420 175 RLLNEDFEKSLNQILEEIP----LERKTFLFSATMTKKVRKLQRACLR 218
Cdd:cd17964 157 RLLDMGFRPDLEQILRHLPeknaDPRQTLLFSATVPDEVQQIARLTLK 204
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
20-223 |
7.37e-56 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 183.93 E-value: 7.37e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 20 LVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALLEyvydsepKKGRRPDPAFFACVLSPTR 99
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILLK-------RKANLKKGQVGALIISPTR 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 100 ELAIQIAEQFEALGADIS--LRCAVLVGGIDrMQQTIA--LGKRPHVIVATPGRLWDHMS-DTKGFSLKSLKYLVLDEAD 174
Cdd:cd17960 74 ELATQIYEVLQSFLEHHLpkLKCQLLIGGTN-VEEDVKkfKRNGPNILVGTPGRLEELLSrKADKVKVKSLEVLVLDEAD 152
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 18424420 175 RLLNEDFEKSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNPVKI 223
Cdd:cd17960 153 RLLDLGFEADLNRILSKLPKQRRTGLFSATQTDAVEELIKAGLRNPVRV 201
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
20-223 |
3.60e-55 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 182.90 E-value: 3.60e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 20 LVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALLEYVYDSEPKKGRRPdpafFACVLSPTR 99
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLPPLDEETKDDGP----YALILAPTR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 100 ELAIQIAEQFEALGADISLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDHMsDTKGFSLKSLKYLVLDEADRLLNE 179
Cdd:cd17945 77 ELAQQIEEETQKFAKPLGIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCL-ERRLLVLNQCTYVVLDEADRMIDM 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18424420 180 DFEKSLNQILEEIPLE--------------------RKTFLFSATMTKKVRKLQRACLRNPVKI 223
Cdd:cd17945 156 GFEPQVTKILDAMPVSnkkpdteeaeklaasgkhryRQTMMFTATMPPAVEKIAKGYLRRPVVV 219
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
21-220 |
7.44e-55 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 181.40 E-value: 7.44e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 21 VKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILqallEYVYdsepKKGRRPDPAFFACVLSPTRE 100
Cdd:cd17942 2 LKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAI----ELLY----KLKFKPRNGTGVIIISPTRE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 101 LAIQIAEQFEALGADISLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDHMSDTKGFSLKSLKYLVLDEADRLLNED 180
Cdd:cd17942 74 LALQIYGVAKELLKYHSQTFGIVIGGANRKAEAEKLGKGVNILVATPGRLLDHLQNTKGFLYKNLQCLIIDEADRILEIG 153
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 18424420 181 FEKSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNP 220
Cdd:cd17942 154 FEEEMRQIIKLLPKRRQTMLFSATQTRKVEDLARISLKKK 193
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
10-366 |
2.12e-52 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 184.22 E-value: 2.12e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 10 TFAELGVREELVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALLEYVYDsEPKKGRRPdpa 89
Cdd:PLN00206 122 SFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRCCTIRSG-HPSEQRNP--- 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 90 fFACVLSPTRELAIQIAEQFEALGADISLRCAVLVGG------IDRMQQTIALgkrphvIVATPGRLWDHMSdTKGFSLK 163
Cdd:PLN00206 198 -LAMVLTPTRELCVQVEDQAKVLGKGLPFKTALVVGGdampqqLYRIQQGVEL------IVGTPGRLIDLLS-KHDIELD 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 164 SLKYLVLDEADRLLNEDFEKSLNQILEEIPlERKTFLFSATMTKKVRKLQRACLRNPVKIEAASKYSTVDTLKQQYRFVA 243
Cdd:PLN00206 270 NVSVLVLDEVDCMLERGFRDQVMQIFQALS-QPQVLLFSATVSPEVEKFASSLAKDIILISIGNPNRPNKAVKQLAIWVE 348
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 244 AKYKDCYLVYILSE----MPESTSMIFTRTcdGTRFLALVLRSL-GFRAIPISGQMTQSKRLGALNKFKAGECNILVCTD 318
Cdd:PLN00206 349 TKQKKQKLFDILKSkqhfKPPAVVFVSSRL--GADLLANAITVVtGLKALSIHGEKSMKERREVMKSFLVGEVPVIVATG 426
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 18424420 319 VASRGLDIPSVDVVINYDIPTNSKDYIHRVGRTARAGRSGVGISLVNQ 366
Cdd:PLN00206 427 VLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFVNE 474
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
20-223 |
1.01e-50 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 170.63 E-value: 1.01e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 20 LVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPIL-----QALLEyvydsepkkgRRPDPAffACV 94
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIvhinaQPPLE----------RGDGPI--VLV 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 95 LSPTRELAIQIAEQFEALGADISLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDhMSDTKGFSLKSLKYLVLDEAD 174
Cdd:cd17966 69 LAPTRELAQQIQQEANKFGGSSRLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLID-FLDQGKTNLRRVTYLVLDEAD 147
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 18424420 175 RLLNEDFEKSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNPVKI 223
Cdd:cd17966 148 RMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRRLAEDFLKDYIQV 196
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
8-223 |
3.65e-50 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 169.87 E-value: 3.65e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 8 VKTFAELGVREELVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPilqaLLEYVYDSEPKKgrrPD 87
Cdd:cd17953 11 IQKWSQCGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLP----MFRHIKDQRPVK---PG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 88 PAFFACVLSPTRELAIQIAEQFEALGADISLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWD--HMSDTKGFSLKSL 165
Cdd:cd17953 84 EGPIGLIMAPTRELALQIYVECKKFSKALGLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDilTANNGRVTNLRRV 163
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 18424420 166 KYLVLDEADRLLNEDFEKSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNPVKI 223
Cdd:cd17953 164 TYVVLDEADRMFDMGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKPIEI 221
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
13-223 |
3.94e-49 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 166.35 E-value: 3.94e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 13 ELGVREELVKACERLGWKNPSKIQAEA-LPFaLEGKDVIGLAQTGSGKTGAFAIPILQALleyvyDSEPKKGRrpdpaff 91
Cdd:cd17939 1 DMGLSEDLLRGIYAYGFEKPSAIQQRAiVPI-IKGRDVIAQAQSGTGKTATFSIGALQRI-----DTTVRETQ------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 92 ACVLSPTRELAIQIAEQFEALGADISLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDHMSDtKGFSLKSLKYLVLD 171
Cdd:cd17939 68 ALVLAPTRELAQQIQKVVKALGDYMGVKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQR-RSLRTDKIKMFVLD 146
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 18424420 172 EADRLLNEDFEKSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNPVKI 223
Cdd:cd17939 147 EADEMLSRGFKDQIYDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDPVRI 198
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
20-223 |
4.17e-49 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 166.44 E-value: 4.17e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 20 LVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALLEyvyDSEPKKGRRPdpafFACVLSPTR 99
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHIMD---QRELEKGEGP----IAVIVAPTR 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 100 ELAIQIAEQFEALGADISLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDhMSDTKGFSLKSLKYLVLDEADRLLNE 179
Cdd:cd17952 74 ELAQQIYLEAKKFGKAYNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLID-MVKKKATNLQRVTYLVLDEADRMFDM 152
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 18424420 180 DFEKSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNPVKI 223
Cdd:cd17952 153 GFEYQVRSIVGHVRPDRQTLLFSATFKKKIEQLARDILSDPIRV 196
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
11-221 |
1.13e-48 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 165.57 E-value: 1.13e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 11 FAELGVREELVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALLeyvydsepkkgrrpdpaf 90
Cdd:cd17938 1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQIVV------------------ 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 91 fACVLSPTRELAIQIAEQFEALGA---DISLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDHMSDTKgFSLKSLKY 167
Cdd:cd17938 63 -ALILEPSRELAEQTYNCIENFKKyldNPKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGK-LDLSSVRF 140
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18424420 168 LVLDEADRLLNEDFEKSLNQILEEIP------LERKTFLFSATM-TKKVRKLQRACLRNPV 221
Cdd:cd17938 141 FVLDEADRLLSQGNLETINRIYNRIPkitsdgKRLQVIVCSATLhSFEVKKLADKIMHFPT 201
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
25-223 |
5.34e-48 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 163.91 E-value: 5.34e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 25 ERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALLeyvydSEPKKGRRPDPAFfACVLSPTRELAIQ 104
Cdd:cd17949 7 SKMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLL-----SLEPRVDRSDGTL-ALVLVPTRELALQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 105 IAEQFEALgadisLRCA------VLVGGIDRMQQTIALGKRPHVIVATPGRLWDHMSDTKGFSLKSLKYLVLDEADRLLN 178
Cdd:cd17949 81 IYEVLEKL-----LKPFhwivpgYLIGGEKRKSEKARLRKGVNILIATPGRLLDHLKNTQSFDVSNLRWLVLDEADRLLD 155
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 18424420 179 EDFEKSLNQILEEI-------------PLERKTFLFSATMTKKVRKLQRACLRNPVKI 223
Cdd:cd17949 156 MGFEKDITKILELLddkrskaggekskPSRRQTVLVSATLTDGVKRLAGLSLKDPVYI 213
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
11-223 |
1.25e-47 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 162.47 E-value: 1.25e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 11 FAELGVREELVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALleyvydsEPKKgrrpdPAF 90
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKI-------DPKK-----DVI 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 91 FACVLSPTRELAIQIAEQFEALGADISLRCAVLVGG------IDRMQQTIalgkrpHVIVATPGRLWDHMSdtKGFS-LK 163
Cdd:cd17940 69 QALILVPTRELALQTSQVCKELGKHMGVKVMVTTGGtslrddIMRLYQTV------HVLVGTPGRILDLAK--KGVAdLS 140
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 164 SLKYLVLDEADRLLNEDFEKSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNPVKI 223
Cdd:cd17940 141 HCKTLVLDEADKLLSQDFQPIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNPYEI 200
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
25-237 |
2.77e-47 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 161.51 E-value: 2.77e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 25 ERLGWKNPSKIQAEALPFALEG-KDVIGLAQTGSGKTGAFAIPILQALLEYVYDSepkkgrrpdpaffACVLSPTRELAI 103
Cdd:smart00487 2 EKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALKRGKGGR-------------VLVLVPTRELAE 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 104 QIAEQFEALGADISLRCAVLVGGIDRMQQTIALGK-RPHVIVATPGRLWDHMSDtKGFSLKSLKYLVLDEADRLLNEDFE 182
Cdd:smart00487 69 QWAEELKKLGPSLGLKVVGLYGGDSKREQLRKLESgKTDILVTTPGRLLDLLEN-DKLSLSNVDLVILDEAHRLLDGGFG 147
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 18424420 183 KSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNPVKIEaaSKYSTVDTLKQ 237
Cdd:smart00487 148 DQLEKLLKLLPKNVQLLLLSATPPEEIENLLELFLNDPVFID--VGFTPLEPIEQ 200
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
25-223 |
5.05e-46 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 158.14 E-value: 5.05e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 25 ERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALLEyvydsepkkgRRPDPAFFACVLSPTRELAIQ 104
Cdd:cd17957 6 EESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLGK----------PRKKKGLRALILAPTRELASQ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 105 IAEQFEALGADISLRCAVLVGGI-DRMQQTIALGKRPHVIVATPGRLWDHMSDTKgFSLKSLKYLVLDEADRLLNEDFEK 183
Cdd:cd17957 76 IYRELLKLSKGTGLRIVLLSKSLeAKAKDGPKSITKYDILVSTPLRLVFLLKQGP-IDLSSVEYLVLDEADKLFEPGFRE 154
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 18424420 184 SLNQILE--EIPLERKTFlFSATMTKKVRKLQRACLRNPVKI 223
Cdd:cd17957 155 QTDEILAacTNPNLQRSL-FSATIPSEVEELARSVMKDPIRI 195
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
20-220 |
2.43e-45 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 157.41 E-value: 2.43e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 20 LVKACERLGWKNPSKIQAEALPFALEG---------KDVIGLAQTGSGKTGAFAIPILQALLEyvydsepkkgrRPDPAF 90
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAAVIPWLLPSskstppyrpGDLCVSAPTGSGKTLAYVLPIVQALSK-----------RVVPRL 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 91 FACVLSPTRELAIQIAEQFEALGADISLRCAVLVGGIDRMQQTIALGK--------RPHVIVATPGRLWDHMSDTKGFSL 162
Cdd:cd17956 70 RALIVVPTKELVQQVYKVFESLCKGTGLKVVSLSGQKSFKKEQKLLLVdtsgrylsRVDILVATPGRLVDHLNSTPGFTL 149
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18424420 163 KSLKYLVLDEADRLLNEDFEKSLNQILEEI------------------PLERK--TFLFSATMTKKVRKLQRACLRNP 220
Cdd:cd17956 150 KHLRFLVIDEADRLLNQSFQDWLETVMKALgrptapdlgsfgdanlleRSVRPlqKLLFSATLTRDPEKLSSLKLHRP 227
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
20-223 |
5.85e-45 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 155.57 E-value: 5.85e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 20 LVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIP-ILQALleyvyDSEPKKGRRPDPAFFACVLSPT 98
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPlIMFAL-----EQEKKLPFIKGEGPYGLIVCPS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 99 RELAIQ---IAEQF-EALGAD--ISLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDhMSDTKGFSLKSLKYLVLDE 172
Cdd:cd17951 76 RELARQtheVIEYYcKALQEGgyPQLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMD-MLNKKKINLDICRYLCLDE 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 18424420 173 ADRLLNEDFEKSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNPVKI 223
Cdd:cd17951 155 ADRMIDMGFEEDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTV 205
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
8-218 |
1.43e-43 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 153.97 E-value: 1.43e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 8 VKTFAELGVREELVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALL-EYVYDSEPKKGRRP 86
Cdd:cd18052 42 ILTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMMkEGLTASSFSEVQEP 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 87 DpaffACVLSPTRELAIQIAEQFEALGADISLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDHMSDTKgFSLKSLK 166
Cdd:cd18052 122 Q----ALIVAPTRELANQIFLEARKFSYGTCIRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFIGRGK-ISLSKLK 196
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 18424420 167 YLVLDEADRLLNEDFEKSLNQILEE--IPL--ERKTFLFSATMTKKVRKLQRACLR 218
Cdd:cd18052 197 YLILDEADRMLDMGFGPEIRKLVSEpgMPSkeDRQTLMFSATFPEEIQRLAAEFLK 252
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
11-223 |
1.01e-41 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 146.82 E-value: 1.01e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 11 FAELGVREELVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALleyvyDSEpkkgrrpDPAF 90
Cdd:cd18046 1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQI-----DTS-------LKAT 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 91 FACVLSPTRELAIQIAEQFEALGADISLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDhMSDTKGFSLKSLKYLVL 170
Cdd:cd18046 69 QALVLAPTRELAQQIQKVVMALGDYMGIKCHACIGGTSVRDDAQKLQAGPHIVVGTPGRVFD-MINRRYLRTDYIKMFVL 147
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 18424420 171 DEADRLLNEDFEKSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNPVKI 223
Cdd:cd18046 148 DEADEMLSRGFKDQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDPIRI 200
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
20-223 |
2.50e-41 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 145.68 E-value: 2.50e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 20 LVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPilqALLEYVYDSEPKkGRRPDPafFACVLSPTR 99
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLP---GFIHLDLQPIPR-EQRNGP--GVLVLTPTR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 100 ELAIQIAEQFEALGADiSLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDhMSDTKGFSLKSLKYLVLDEADRLLNE 179
Cdd:cd17958 75 ELALQIEAECSKYSYK-GLKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLND-LQMNNVINLKSITYLVLDEADRMLDM 152
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 18424420 180 DFEKSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNPVKI 223
Cdd:cd17958 153 GFEPQIRKILLDIRPDRQTIMTSATWPDGVRRLAQSYLKDPMIV 196
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
8-219 |
4.30e-41 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 146.72 E-value: 4.30e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 8 VKTFAELGVREELVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALLE-----YVYDSEPKK 82
Cdd:cd18051 20 IETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIYEqgpgeSLPSESGYY 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 83 GRR---PdpafFACVLSPTRELAIQIAEQFEALGADISLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDHMSDTKg 159
Cdd:cd18051 100 GRRkqyP----LALVLAPTRELASQIYDEARKFAYRSRVRPCVVYGGADIGQQMRDLERGCHLLVATPGRLVDMLERGK- 174
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18424420 160 FSLKSLKYLVLDEADRLLNEDFEKSLNQILEEIPL----ERKTFLFSATMTKKVRKLQRACLRN 219
Cdd:cd18051 175 IGLDYCKYLVLDEADRMLDMGFEPQIRRIVEQDTMpptgERQTLMFSATFPKEIQMLARDFLDN 238
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
20-224 |
1.95e-39 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 140.48 E-value: 1.95e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 20 LVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALLeyvydsepKKGRRPDpaffACVLSPTR 99
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLD--------LERRHPQ----VLILAPTR 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 100 ELAIQIAEQFEALGADI-SLRCAVLVGGIDRMQQTIALgKRPHVIVATPGRLwDHMSDTKGFSLKSLKYLVLDEADRLLN 178
Cdd:cd17943 69 EIAVQIHDVFKKIGKKLeGLKCEVFIGGTPVKEDKKKL-KGCHIAVGTPGRI-KQLIELGALNVSHVRLFVLDEADKLME 146
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 18424420 179 EDFEKSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNPVKIE 224
Cdd:cd17943 147 GSFQKDVNWIFSSLPKNKQVIAFSATYPKNLDNLLARYMRKPVLVR 192
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
11-224 |
8.00e-39 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 139.40 E-value: 8.00e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 11 FAELGVREELVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALleyvydsepkkgrRPDPAF 90
Cdd:cd17950 4 FRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQL-------------EPVDGQ 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 91 FAC-VLSPTRELAIQIAEQFEALGADI-SLRCAVLVGG--IDRMQQTIAlGKRPHVIVATPGRLWDHMSDtKGFSLKSLK 166
Cdd:cd17950 71 VSVlVICHTRELAFQISNEYERFSKYMpNVKTAVFFGGvpIKKDIEVLK-NKCPHIVVGTPGRILALVRE-KKLKLSHVK 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 18424420 167 YLVLDEADRLLNE-DFEKSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNPVKIE 224
Cdd:cd17950 149 HFVLDECDKMLEQlDMRRDVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPLEIF 207
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
25-223 |
1.11e-38 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 138.84 E-value: 1.11e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 25 ERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALLEYVydsepkkgRRPdpafFACVLSPTRELAIQ 104
Cdd:cd17962 6 KKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCLTEH--------RNP----SALILTPTRELAVQ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 105 IAEQFEALGADI-SLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDHMSDTKgFSLKSLKYLVLDEADRLLNEDFEK 183
Cdd:cd17962 74 IEDQAKELMKGLpPMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQSS-VELDNIKIVVVDEADTMLKMGFQQ 152
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 18424420 184 SLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNPVKI 223
Cdd:cd17962 153 QVLDILENISHDHQTILVSATIPRGIEQLAGQLLQNPVRI 192
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
8-223 |
2.36e-36 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 133.98 E-value: 2.36e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 8 VKTFAELGVREELVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPilqALLEYVYDSEPKKGRRPd 87
Cdd:cd18049 23 VLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLP---AIVHINHQPFLERGDGP- 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 88 pafFACVLSPTRELAIQIAEQFEALGADISLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDHMSDTKGfSLKSLKY 167
Cdd:cd18049 99 ---ICLVLAPTRELAQQVQQVAAEYGRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKT-NLRRCTY 174
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 18424420 168 LVLDEADRLLNEDFEKSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNPVKI 223
Cdd:cd18049 175 LVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHI 230
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
18-223 |
1.08e-35 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 130.77 E-value: 1.08e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 18 EELVKACERLGWKNPSKIQAEALPFALEG--KDVIGLAQTGSGKTGAFAIpilqALLEYVydsepkKGRRPDPAffACVL 95
Cdd:cd17963 3 PELLKGLYAMGFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVL----AMLSRV------DPTLKSPQ--ALCL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 96 SPTRELAIQIAEQFEALGADISLRCAVLVGGID-RMQQTIalgkRPHVIVATPGRLWDHMsDTKGFSLKSLKYLVLDEAD 174
Cdd:cd17963 71 APTRELARQIGEVVEKMGKFTGVKVALAVPGNDvPRGKKI----TAQIVIGTPGTVLDWL-KKRQLDLKKIKILVLDEAD 145
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 18424420 175 RLLNED-FEKSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNPVKI 223
Cdd:cd17963 146 VMLDTQgHGDQSIRIKRMLPRNCQILLFSATFPDSVRKFAEKIAPNANTI 195
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
29-223 |
3.52e-35 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 131.67 E-value: 3.52e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 29 WKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPilqALLEYVYDSEPKKGRRPdpafFACVLSPTRELAIQIAEQ 108
Cdd:cd18050 82 FKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLP---AIVHINHQPYLERGDGP----ICLVLAPTRELAQQVQQV 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 109 FEALGADISLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDHMSDTKGfSLKSLKYLVLDEADRLLNEDFEKSLNQI 188
Cdd:cd18050 155 ADDYGKSSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKT-NLRRCTYLVLDEADRMLDMGFEPQIRKI 233
|
170 180 190
....*....|....*....|....*....|....*
gi 18424420 189 LEEIPLERKTFLFSATMTKKVRKLQRACLRNPVKI 223
Cdd:cd18050 234 VDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYVQI 268
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
247-355 |
3.63e-34 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 123.47 E-value: 3.63e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 247 KDCYLVYILSEMPESTSMIFTRTCDGTRfLALVLRSLGFRAIPISGQMTQSKRLGALNKFKAGECNILVCTDVASRGLDI 326
Cdd:pfam00271 2 KLEALLELLKKERGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDL 80
|
90 100
....*....|....*....|....*....
gi 18424420 327 PSVDVVINYDIPTNSKDYIHRVGRTARAG 355
Cdd:pfam00271 81 PDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
11-223 |
6.77e-34 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 126.04 E-value: 6.77e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 11 FAELGVREELVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALLEYVYDSEpkkgrrpdpaf 90
Cdd:cd18045 1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQ----------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 91 fACVLSPTRELAIQIAEQFEALGADISLRCAVLVGG------IDRMQQTIalgkrpHVIVATPGRLWDhMSDTKGFSLKS 164
Cdd:cd18045 70 -ALILSPTRELAVQIQKVLLALGDYMNVQCHACIGGtsvgddIRKLDYGQ------HIVSGTPGRVFD-MIRRRSLRTRH 141
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 18424420 165 LKYLVLDEADRLLNEDFEKSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNPVKI 223
Cdd:cd18045 142 IKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDPIRI 200
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
20-212 |
1.84e-32 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 123.25 E-value: 1.84e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 20 LVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALLEYvydsePKKGRRPDPAFFACVLSPTR 99
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRY-----KLLAEGPFNAPRGLVITPSR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 100 ELAIQIAEQFEALGADISLRCAVLVGGidRMQQTIALGKRPHV--IVATPGRLWdHMSDTKGFSLKSLKYLVLDEADRLL 177
Cdd:cd17948 76 ELAEQIGSVAQSLTEGLGLKVKVITGG--RTKRQIRNPHFEEVdiLVATPGALS-KLLTSRIYSLEQLRHLVLDEADTLL 152
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 18424420 178 NEDFEKSLNQILEEIPLE-----------RKT--FLFSATMTKKVRKL 212
Cdd:cd17948 153 DDSFNEKLSHFLRRFPLAsrrsentdgldPGTqlVLVSATMPSGVGEV 200
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
274-355 |
3.94e-30 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 111.92 E-value: 3.94e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 274 RFLALVLRSLGFRAIPISGQMTQSKRLGALNKFKAGECNILVCTDVASRGLDIPSVDVVINYDIPTNSKDYIHRVGRTAR 353
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
..
gi 18424420 354 AG 355
Cdd:smart00490 81 AG 82
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
35-233 |
5.52e-29 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 112.63 E-value: 5.52e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 35 IQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALLEyvyDSEP-KKGRRPDpaffACVLSPTRELAIQIAEQFEALG 113
Cdd:cd17944 16 IQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLQE---DQQPrKRGRAPK----VLVLAPTRELANQVTKDFKDIT 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 114 ADISLRCavLVGGIDRMQQTIALGKRPHVIVATPGRLWDHMSDTKgFSLKSLKYLVLDEADRLLNEDFEKSLNQIL---- 189
Cdd:cd17944 89 RKLSVAC--FYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGR-LDLTKLKHVVLDEVDQMLDMGFAEQVEEILsvsy 165
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 18424420 190 ----EEIPlerKTFLFSATMTKKVRKLQRACLRnpvkieaaSKYSTVD 233
Cdd:cd17944 166 kkdsEDNP---QTLLFSATCPDWVYNVAKKYMK--------SQYEQVD 202
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
8-209 |
1.55e-21 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 92.78 E-value: 1.55e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 8 VKTFAELGVREELVKACERLGWKNPSKIQAEALPFALEG--KDVIGLAQTGSGKTGAFAIpilqALLEYVYDSEpkkgrr 85
Cdd:cd18048 17 VKSFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVL----AMLSRVDALK------ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 86 pdpAFFACV-LSPTRELAIQIAEQFEALG---ADISLRCAVLVGGIDRMQQTIAlgkrpHVIVATPGRLWDHMSDTKGFS 161
Cdd:cd18048 87 ---LYPQCLcLSPTFELALQTGKVVEEMGkfcVGIQVIYAIRGNRPGKGTDIEA-----QIVIGTPGTVLDWCFKLRLID 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 18424420 162 LKSLKYLVLDEADRLLN-EDFEKSLNQILEEIPLERKTFLFSATMTKKV 209
Cdd:cd18048 159 VTNISVFVLDEADVMINvQGHSDHSVRVKRSMPKECQMLLFSATFEDSV 207
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
46-204 |
3.05e-21 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 89.77 E-value: 3.05e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 46 GKDVIGLAQTGSGKTGAFAIPILQALLEYvydsepkkgrrpdpAFFACVLSPTRELAIQIAEQFEALgADISLRCAVLVG 125
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLLLLKK--------------GKKVLVLVPTKALALQTAERLREL-FGPGIRVAVLVG 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 126 GIDRMQQTIALGKRPHVIVATPGRLWDHMSDTKGFSLKSLKYLVLDEADRLLNEDFEKSLN--QILEEIPLERKTFLFSA 203
Cdd:cd00046 66 GSSAEEREKNKLGDADIIIATPDMLLNLLLREDRLFLKDLKLIIVDEAHALLIDSRGALILdlAVRKAGLKNAQVILLSA 145
|
.
gi 18424420 204 T 204
Cdd:cd00046 146 T 146
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
254-355 |
1.25e-20 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 94.80 E-value: 1.25e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 254 ILSEMPESTSMIFTR---TCDgtrflALV--LRSLGFRAIPISGQ--------MTQSKRLGALNKFKAGECNILVCTDVA 320
Cdd:COG1111 347 QLGTNPDSRIIVFTQyrdTAE-----MIVefLSEPGIKAGRFVGQaskegdkgLTQKEQIEILERFRAGEFNVLVATSVA 421
|
90 100 110
....*....|....*....|....*....|....*.
gi 18424420 321 SRGLDIPSVDVVINYD-IPTNSKdYIHRVGRTARAG 355
Cdd:COG1111 422 EEGLDIPEVDLVIFYEpVPSEIR-SIQRKGRTGRKR 456
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
9-220 |
1.28e-19 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 86.70 E-value: 1.28e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 9 KTFAELGVREELVKACERLGWKNPSKIQAEALPFALEG--KDVIGLAQTGSGKTGAFAIpilqALLEYVydsepkkgrrp 86
Cdd:cd18047 1 KSFEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVL----AMLSQV----------- 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 87 DPA--FFACV-LSPTRELAIQIAEQFEALGA---DISLRCAVLVggiDRMQQTIALgkRPHVIVATPGRLWDHMSDTKGF 160
Cdd:cd18047 66 EPAnkYPQCLcLSPTYELALQTGKVIEQMGKfypELKLAYAVRG---NKLERGQKI--SEQIVIGTPGTVLDWCSKLKFI 140
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18424420 161 SLKSLKYLVLDEADRLL-NEDFEKSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNP 220
Cdd:cd18047 141 DPKKIKVFVLDEADVMIaTQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDP 201
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
53-214 |
2.37e-16 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 78.57 E-value: 2.37e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 53 AQTGSGKTGAFAIPILQAL----LEYVYDSEPKKGRRPDPAFF-ACVLSPTRELAIQIAEQFEALGADISLRCAVLVGGI 127
Cdd:cd17965 68 AETGSGKTLAYLAPLLDYLkrqeQEPFEEAEEEYESAKDTGRPrSVILVPTHELVEQVYSVLKKLSHTVKLGIKTFSSGF 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 128 DRMQQTIALG--KRPHVIVATPGRLwDHMSDTKGFSLKSLKYLVLDEADRLLNEDFEKSLNQILEEIPLERKTFLFSATM 205
Cdd:cd17965 148 GPSYQRLQLAfkGRIDILVTTPGKL-ASLAKSRPKILSRVTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSATI 226
|
....*....
gi 18424420 206 TKKVRKLQR 214
Cdd:cd17965 227 PKEFDKTLR 235
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
254-358 |
4.62e-16 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 80.69 E-value: 4.62e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 254 ILSEMPESTSMIFTRTCDGTRFLALVLRSLGFRAIPISGQ--------MTQSKRLGALNKFKAGECNILVCTDVASRGLD 325
Cdd:PRK13766 359 QLGKNPDSRIIVFTQYRDTAEKIVDLLEKEGIKAVRFVGQaskdgdkgMSQKEQIEILDKFRAGEFNVLVSTSVAEEGLD 438
|
90 100 110
....*....|....*....|....*....|....
gi 18424420 326 IPSVDVVINYD-IPTNSKdYIHRVGRTARaGRSG 358
Cdd:PRK13766 439 IPSVDLVIFYEpVPSEIR-SIQRKGRTGR-QEEG 470
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
15-361 |
9.37e-16 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 79.88 E-value: 9.37e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 15 GVREELVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALLEyvydsepkkgrrpDPAFFACV 94
Cdd:COG1205 40 WLPPELRAALKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEALLE-------------DPGATALY 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 95 LSPTRELAiqiAEQFEAL-----GADISLRCAVLVGGIDRmQQTIALGKRPHVIVATP-----GrLWDHMSDTKGFsLKS 164
Cdd:COG1205 107 LYPTKALA---RDQLRRLrelaeALGLGVRVATYDGDTPP-EERRWIREHPDIVLTNPdmlhyG-LLPHHTRWARF-FRN 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 165 LKYLVLDEA---------------DRLLnedfekslnQILEEI---PlerkTFLF-SATMT-----------KKVR---- 210
Cdd:COG1205 181 LRYVVIDEAhtyrgvfgshvanvlRRLR---------RICRHYgsdP----QFILaSATIGnpaehaerltgRPVTvvde 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 211 ------KLQRACLRNPVKIEAASKYSTVDTLKQQYRFVAAKYKdcylvyilsempestSMIFTRTCDGTRFLALVLR--- 281
Cdd:COG1205 248 dgsprgERTFVLWNPPLVDDGIRRSALAEAARLLADLVREGLR---------------TLVFTRSRRGAELLARYARral 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 282 ---SLGFRAIPISGQMTQSKRLGALNKFKAGECNILVCTDVASRGLDIPSVDVVINYDIPTNSKDYIHRVGRTARAGRSG 358
Cdd:COG1205 313 repDLADRVAAYRAGYLPEERREIERGLRSGELLGVVSTNALELGIDIGGLDAVVLAGYPGTRASFWQQAGRAGRRGQDS 392
|
...
gi 18424420 359 VGI 361
Cdd:COG1205 393 LVV 395
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
36-431 |
1.68e-15 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 78.91 E-value: 1.68e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 36 QAEAL-----PFALEGKDVIGLAQTGSGKTGAFAipilqALLEYVYDSEPkkgrrpdpaffACVLSPTRELAIQIAEQFE 110
Cdd:COG1061 85 QQEALeallaALERGGGRGLVVAPTGTGKTVLAL-----ALAAELLRGKR-----------VLVLVPRRELLEQWAEELR 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 111 ALgadisLRCAVLVGGIDRmqqtialgKRPHVIVATPGRLWDHMSDTKGFSLKSLkyLVLDEADRLLNEDFEKslnqILE 190
Cdd:COG1061 149 RF-----LGDPLAGGGKKD--------SDAPITVATYQSLARRAHLDELGDRFGL--VIIDEAHHAGAPSYRR----ILE 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 191 EIPlERKTFLFSAT------------------MTKKVRKLQRA-CLRNP----VKIEAASKYSTVDTLKQQYRFV---AA 244
Cdd:COG1061 210 AFP-AAYRLGLTATpfrsdgreillflfdgivYEYSLKEAIEDgYLAPPeyygIRVDLTDERAEYDALSERLREAlaaDA 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 245 KYKDCYLVYILSEMPESTS-MIFTRTCDGTRFLALVLRSLGFRAIPISGQMTQSKRLGALNKFKAGECNILVCTDVASRG 323
Cdd:COG1061 289 ERKDKILRELLREHPDDRKtLVFCSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEG 368
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 324 LDIPSVDVVINYDiPTNSK-DYIHRVGRTARA---GRSGVGISLVNQYELEWYIQIEKLIGKKLPEYpAEEDEVLSLLER 399
Cdd:COG1061 369 VDVPRLDVAILLR-PTGSPrEFIQRLGRGLRPapgKEDALVYDFVGNDVPVLEELAKDLRDLAGYRV-EFLDEEESEELA 446
|
410 420 430
....*....|....*....|....*....|..
gi 18424420 400 VAEAKKLSAMNMKESGGRKRRGEDDEESERFL 431
Cdd:COG1061 447 LLIAVKPALEVKGELEEELLEELELLEDALLL 478
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
293-354 |
1.71e-15 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 73.01 E-value: 1.71e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18424420 293 QMTQSKRLGALNKFKAGECNILVCTDVASRGLDIPSVDVVINYDIPTNSKDYIHRVGRtARA 354
Cdd:cd18802 73 LMTQRKQKETLDKFRDGELNLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGR-ARA 133
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
36-173 |
3.78e-13 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 67.61 E-value: 3.78e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 36 QAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALLEyvydsepKKGRRpdpaffACVLSPTRELAIQIAEQFEALGAD 115
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEALLR-------DPGSR------ALYLYPTKALAQDQLRSLRELLEQ 71
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18424420 116 I--SLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLwDHM----SDTKGFSLKSLKYLVLDEA 173
Cdd:cd17923 72 LglGIRVATYDGDTPREERRAIIRNPPRILLTNPDML-HYAllphHDRWARFLRNLRYVVLDEA 134
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
256-358 |
5.33e-13 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 66.23 E-value: 5.33e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 256 SEMPESTSMIFTRTCDGTRFLA--LVLRSLGFRAIPISGQ--------MTQSKRLGALNKFKAGECNILVCTDVASRGLD 325
Cdd:cd18801 26 QEGSDTRVIIFSEFRDSAEEIVnfLSKIRPGIRATRFIGQasgksskgMSQKEQKEVIEQFRKGGYNVLVATSIGEEGLD 105
|
90 100 110
....*....|....*....|....*....|...
gi 18424420 326 IPSVDVVINYDIPTNSKDYIHRVGRTARaGRSG 358
Cdd:cd18801 106 IGEVDLIICYDASPSPIRMIQRMGRTGR-KRQG 137
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
312-365 |
1.15e-10 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 57.33 E-value: 1.15e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 18424420 312 NILVCTDVASRGLDIPSVDVVINYDIPTNSKDYIHRVGRTARAGRSGVGISLVN 365
Cdd:cd18785 24 EILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDEGEVILFV 77
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
16-173 |
4.62e-08 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 55.29 E-value: 4.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 16 VREELVKACERLGWK--NPSkiQAEALPFAL-EGKDVIGLAQTGSGKTGAFAIPILQALLeyvydsepKKGRrpdpaffA 92
Cdd:COG1204 7 PLEKVIEFLKERGIEelYPP--QAEALEAGLlEGKNLVVSAPTASGKTLIAELAILKALL--------NGGK-------A 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 93 CVLSPTRELAIQIAEQFEALGADISLRCAVLVGGIDRmqqTIALGKRPHVIVATPGRLwDHMSDTKGFSLKSLKYLVLDE 172
Cdd:COG1204 70 LYIVPLRALASEKYREFKRDFEELGIKVGVSTGDYDS---DDEWLGRYDILVATPEKL-DSLLRNGPSWLRDVDLVVVDE 145
|
.
gi 18424420 173 A 173
Cdd:COG1204 146 A 146
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
46-172 |
4.83e-08 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 52.59 E-value: 4.83e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 46 GKDVIGLAQTGSGKTGAFAIPILQALLeyvydsepkkgRRPDPAFFACVLSPTRELAIQIAEQFEALGADISL--RCAVL 123
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSLA-----------DEPEKGVQVLYISPLKALINDQERRLEEPLDEIDLeiPVAVR 69
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 18424420 124 VGGIDRMQQTIALGKRPHVIVATPGRLWDHMSDTKGFS-LKSLKYLVLDE 172
Cdd:cd17922 70 HGDTSQSEKAKQLKNPPGILITTPESLELLLVNKKLRElFAGLRYVVVDE 119
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
34-204 |
6.21e-08 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 52.26 E-value: 6.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 34 KIQAEAL-PFALEGKDVIGLAQTGSGKTGAFAIPILQALLEYvydsepkKGRrpdpaffACVLSPTRELAIQIAEQFEAL 112
Cdd:cd17921 4 PIQREALrALYLSGDSVLVSAPTSSGKTLIAELAILRALATS-------GGK-------AVYIAPTRALVNQKEADLRER 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 113 GADISLRCAVLVGGIDRMQQTIAlgkRPHVIVATPGRlWDHMSDT-KGFSLKSLKYLVLDEADRLLNEDFEKSLNQILEE 191
Cdd:cd17921 70 FGPLGKNVGLLTGDPSVNKLLLA---EADILVATPEK-LDLLLRNgGERLIQDVRLVVVDEAHLIGDGERGVVLELLLSR 145
|
170
....*....|....*.
gi 18424420 192 IPLERKT--FLF-SAT 204
Cdd:cd17921 146 LLRINKNarFVGlSAT 161
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
251-349 |
2.49e-07 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 49.78 E-value: 2.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 251 LVYILSEMPEST--SMIFTRTcdgTRFLALV---LRSLGFRAIPISGQMTQSKRLGALNKFKA--GECNILVCTDVASRG 323
Cdd:cd18793 16 LLELLEELREPGekVLIFSQF---TDTLDILeeaLRERGIKYLRLDGSTSSKERQKLVDRFNEdpDIRVFLLSTKAGGVG 92
|
90 100 110
....*....|....*....|....*....|..
gi 18424420 324 LDIPSVDVVINYDIPTNSK------DYIHRVG 349
Cdd:cd18793 93 LNLTAANRVILYDPWWNPAveeqaiDRAHRIG 124
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
185-409 |
4.59e-07 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 52.07 E-value: 4.59e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 185 LNQILEEIPlERKTFLFSATMTKKVRK--LQRACLRNPVKIEaaskySTVD----TLKQQYRFVAAKYKdcYLVYILSEM 258
Cdd:COG0514 157 LGELRERLP-NVPVLALTATATPRVRAdiAEQLGLEDPRVFV-----GSFDrpnlRLEVVPKPPDDKLA--QLLDFLKEH 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 259 PESTSMIFTRTCDGTRFLALVLRSLGFRAIPISGQMTQSKRLGALNKFKAGECNILVCTdVA-SRGLDIPSVDVVINYDI 337
Cdd:COG0514 229 PGGSGIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVAT-IAfGMGIDKPDVRFVIHYDL 307
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18424420 338 PTNSKDYIHRVGRTARAGRSGVGISLvnqYELEWYIQIEKLIGKKLPEYpaeedevlslLERVAEAKKLSAM 409
Cdd:COG0514 308 PKSIEAYYQEIGRAGRDGLPAEALLL---YGPEDVAIQRFFIEQSPPDE----------ERKRVERAKLDAM 366
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
30-173 |
8.15e-07 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 49.57 E-value: 8.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 30 KNPSKIQAEALPFALEgKDVIGLAQTGSGKTgAFAIPILQALLEYVY-DSEPKKgrrpdPAFFacvLSPTRELAIQiaeQ 108
Cdd:cd18034 1 FTPRSYQLELFEAALK-RNTIVVLPTGSGKT-LIAVMLIKEMGELNRkEKNPKK-----RAVF---LVPTVPLVAQ---Q 67
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 109 FEALGADISLRCAVLVGGIDRMQQTIALGK----RPHVIVATPGRLWDHMSdtKGF-SLKSLKYLVLDEA 173
Cdd:cd18034 68 AEAIRSHTDLKVGEYSGEMGVDKWTKERWKeeleKYDVLVMTAQILLDALR--HGFlSLSDINLLIFDEC 135
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
251-358 |
1.05e-06 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 47.97 E-value: 1.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 251 LVYILSEMPESTSMIFTRTCDGTRFLALVLRSLGFRAIPISGQMTQSKRLGALNKFKAGECNILVCTDVASRGLDIPSVD 330
Cdd:cd18794 21 LKRIKVEHLGGSGIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVATVAFGMGIDKPDVR 100
|
90 100
....*....|....*....|....*...
gi 18424420 331 VVINYDIPTNSKDYIHRVGrtaRAGRSG 358
Cdd:cd18794 101 FVIHYSLPKSMESYYQESG---RAGRDG 125
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
34-172 |
3.07e-06 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 47.74 E-value: 3.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 34 KIQAEALPFALEG-KDVIGLAQTGSGKTGAFAIPILQALLEyvYDSEPKKGRRpdpaffACVLSPTRELAIQIA----EQ 108
Cdd:cd18023 4 RIQSEVFPDLLYSdKNFVVSAPTGSGKTVLFELAILRLLKE--RNPLPWGNRK------VVYIAPIKALCSEKYddwkEK 75
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18424420 109 FEALGadisLRCAVLVG-----GIDRMQQTialgkrpHVIVATPGRlWDHMS---DTKGFSLKSLKYLVLDE 172
Cdd:cd18023 76 FGPLG----LSCAELTGdtemdDTFEIQDA-------DIILTTPEK-WDSMTrrwRDNGNLVQLVALVLIDE 135
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
266-351 |
3.10e-06 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 49.45 E-value: 3.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 266 FTRTCDgtrFLALVLRSLGFRAIPISGQMTQSKRLGALNKFKAG-ECN-ILVCTDVASRGLDIPSVDVVINYDIPTN--- 340
Cdd:COG0553 558 FTDTLD---LLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGpEAPvFLISLKAGGEGLNLTAADHVIHYDLWWNpav 634
|
90
....*....|....
gi 18424420 341 ---SKDYIHRVGRT 351
Cdd:COG0553 635 eeqAIDRAHRIGQT 648
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
210-358 |
9.72e-06 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 45.32 E-value: 9.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 210 RKLQRACLRNPVKIEAAskystvdtlkqqyRFVAAKYKDcylvyilsempESTSMIFTRTCDGTRFLALVLRslgfraIP 289
Cdd:cd18789 23 RKRRLLAAMNPNKLRAL-------------EELLKRHEQ-----------GDKIIVFTDNVEALYRYAKRLL------KP 72
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18424420 290 -ISGQMTQSKRLGALNKFKAGECNILVCTDVASRGLDIPSVDVVINYDIPTNSK-DYIHRVGRTARAGRSG 358
Cdd:cd18789 73 fITGETPQSEREEILQNFREGEYNTLVVSKVGDEGIDLPEANVAIQISGHGGSRrQEAQRLGRILRPKKGG 143
|
|
| SF2_C_RecG_TRCF |
cd18792 |
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family ... |
292-336 |
1.44e-05 |
|
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family contains recombination factor RecG and transcription-repair coupling factor TrcF. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350179 [Multi-domain] Cd Length: 160 Bit Score: 44.95 E-value: 1.44e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 18424420 292 GQMTQSKRLGALNKFKAGECNILVCTDVASRGLDIPSVDVVINYD 336
Cdd:cd18792 68 GKMTEDEKEAVMLEFREGEYDILVSTTVIEVGIDVPNANTMIIED 112
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
29-172 |
2.53e-05 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 46.63 E-value: 2.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 29 WKNPSKIQAEALPFALEGKDVIGLAQTGSGKT-GAFaIPILQALLEyvydsEPKKGRRPDPAFfacVL--SPTRELAIQI 105
Cdd:COG1201 22 FGAPTPPQREAWPAIAAGESTLLIAPTGSGKTlAAF-LPALDELAR-----RPRPGELPDGLR---VLyiSPLKALANDI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 106 AEQFEALGADISLRCAVLVGGI------------DRMQQtiaLGKRPHVIVATP--------GRLWDHMsdtkgfsLKSL 165
Cdd:COG1201 93 ERNLRAPLEEIGEAAGLPLPEIrvgvrtgdtpasERQRQ---RRRPPHILITTPeslallltSPDAREL-------LRGV 162
|
....*..
gi 18424420 166 KYLVLDE 172
Cdd:COG1201 163 RTVIVDE 169
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
261-363 |
3.42e-05 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 43.79 E-value: 3.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 261 STSMIFTRTCDGTRFLALVLRSLGFR-----AIPIS-GQMTQSKRLGALNKFKAGECNILVCTDVASRGLDIPSVDVVIN 334
Cdd:cd18796 39 KSTLVFTNTRSQAERLAQRLRELCPDrvppdFIALHhGSLSRELREEVEAALKRGDLKVVVATSSLELGIDIGDVDLVIQ 118
|
90 100
....*....|....*....|....*....
gi 18424420 335 YDIPTNSKDYIHRVGrtaRAGRSGVGISL 363
Cdd:cd18796 119 IGSPKSVARLLQRLG---RSGHRPGAASK 144
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
25-221 |
4.38e-05 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 44.45 E-value: 4.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 25 ERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPilqALLEyvydsepkKGrrpdpafFACVLSPTRELaiq 104
Cdd:cd17920 6 EVFGYDEFRPGQLEAINAVLAGRDVLVVMPTGGGKSLCYQLP---ALLL--------DG-------VTLVVSPLISL--- 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 105 IAEQFEALgADISLRCAVLVGGIDRMQQTIALGKRP----HVIVATPGRLWdhMSDTKGF-----SLKSLKYLVLDEADR 175
Cdd:cd17920 65 MQDQVDRL-QQLGIRAAALNSTLSPEEKREVLLRIKngqyKLLYVTPERLL--SPDFLELlqrlpERKRLALIVVDEAHC 141
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 18424420 176 LLN--EDFEKSLNQI------LEEIPLerktFLFSATMTKKVRK--LQRACLRNPV 221
Cdd:cd17920 142 VSQwgHDFRPDYLRLgrlrraLPGVPI----LALTATATPEVREdiLKRLGLRNPV 193
|
|
| SF2_C_reverse_gyrase |
cd18798 |
C-terminal helicase domain of the reverse gyrase; Reverse gyrase modifies the topological ... |
274-364 |
6.84e-05 |
|
C-terminal helicase domain of the reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350185 [Multi-domain] Cd Length: 174 Bit Score: 43.45 E-value: 6.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 274 RFLALVLRSLGFRAIPISgqmtqSKRLGALNKFKAGECNILVctDVAS------RGLDIP-SVDVVINYDIPTNSkdYIH 346
Cdd:cd18798 41 EELKEFLERHGIKAELAL-----SSTEKNLEKFEEGEIDVLI--GVASyygvlvRGIDLPeRIKYAIFYGVPVTT--YIQ 111
|
90 100
....*....|....*....|
gi 18424420 347 RVGRTAR--AGRSGVGISLV 364
Cdd:cd18798 112 ASGRTSRlyAGGLTKGLSVV 131
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
55-204 |
1.23e-04 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 41.91 E-value: 1.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 55 TGSGKTgafaiPILQALLEYvydsepkkgRRPDPAFFACvlsPTRELAIQIAEQFEALGADISLRcavLVGGIDRMQQTI 134
Cdd:cd17926 27 TGSGKT-----LTALALIAY---------LKELRTLIVV---PTDALLDQWKERFEDFLGDSSIG---LIGGGKKKDFDD 86
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 135 ALgkrphVIVATPGRLWDHMSDTKGFSLKSLkYLVLDEADRLLNEDFEKSLnqileEIPLERKTFLFSAT 204
Cdd:cd17926 87 AN-----VVVATYQSLSNLAEEEKDLFDQFG-LLIVDEAHHLPAKTFSEIL-----KELNAKYRLGLTAT 145
|
|
| PLN03137 |
PLN03137 |
ATP-dependent DNA helicase; Q4-like; Provisional |
246-379 |
1.66e-04 |
|
ATP-dependent DNA helicase; Q4-like; Provisional
Pssm-ID: 215597 [Multi-domain] Cd Length: 1195 Bit Score: 44.12 E-value: 1.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 246 YKDCYLVYILSEMpestsmiftrTCDGtrfLALVLRSLGFRAIPISGQMTQSKRLGALNKFKAGECNILVCTDVASRGLD 325
Cdd:PLN03137 679 FDECGIIYCLSRM----------DCEK---VAERLQEFGHKAAFYHGSMDPAQRAFVQKQWSKDEINIICATVAFGMGIN 745
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 18424420 326 IPSVDVVINYDIPTNSKDYIHRVGrtaRAGRSGVGISLVNQYELEWYIQIEKLI 379
Cdd:PLN03137 746 KPDVRFVIHHSLPKSIEGYHQECG---RAGRDGQRSSCVLYYSYSDYIRVKHMI 796
|
|
| SF2_C_EcoAI-like |
cd18799 |
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family ... |
264-353 |
1.91e-04 |
|
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family is composed of helicase restriction enzymes, including the HsdR subunit of restriction-modification enzymes such as Escherichia coli type I restriction enzyme EcoAI R protein (R.EcoAI). The EcoAI enzyme recognizes 5'-GAGN(7)GTCA-3'. The HsdR or R subunit is required for both nuclease and ATPase activities, but not for modification. These proteins are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350186 [Multi-domain] Cd Length: 116 Bit Score: 41.01 E-value: 1.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 264 MIFTRTCDGTRFLALVLRSLGFRAIPISGQMTQSKR-LGALNKFKAGE--CNILVCTDVASRGLDIPSVDVVInYDIPTN 340
Cdd:cd18799 10 LIFCVSIEHAEFMAEAFNEAGIDAVALNSDYSDRERgDEALILLFFGElkPPILVTVDLLTTGVDIPEVDNVV-FLRPTE 88
|
90
....*....|....
gi 18424420 341 SKD-YIHRVGRTAR 353
Cdd:cd18799 89 SRTlFLQMLGRGLR 102
|
|
| SF2_C_TRCF |
cd18810 |
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair ... |
292-355 |
2.88e-04 |
|
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair coupling factor (TrcF) dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. TrcF is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350197 [Multi-domain] Cd Length: 151 Bit Score: 41.18 E-value: 2.88e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18424420 292 GQMTQSKRLGALNKFKAGECNILVCTDVASRGLDIPSVDVVINYDIPTNSKDYIH----RVGRTARAG 355
Cdd:cd18810 59 GQMTENELEEVMLEFAKGEYDILVCTTIIESGIDIPNANTIIIERADKFGLAQLYqlrgRVGRSKERA 126
|
|
| SF2_C_RecG |
cd18811 |
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a ... |
231-350 |
3.84e-04 |
|
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. RecG helps process Holliday junction intermediates to mature products by catalyzing branch migration. It is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350198 [Multi-domain] Cd Length: 159 Bit Score: 40.79 E-value: 3.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 231 TVDTLKQQYRFV---AAKYKDCYLVYILSEmpESTSMIFTRTCDGTRFLALVLRSlGFRAIPISGQMTQSKRLGALNKFK 307
Cdd:cd18811 8 FHTRLDKVYEFVreeIAKGRQAYVIYPLIE--ESEKLDLKAAVAMYEYLKERFRP-ELNVGLLHGRLKSDEKDAVMAEFR 84
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 18424420 308 AGECNILVCTDVASRGLDIPSVDVVINYDIPTNSKDYIH----RVGR 350
Cdd:cd18811 85 EGEVDILVSTTVIEVGVDVPNATVMVIEDAERFGLSQLHqlrgRVGR 131
|
|
| PRK05580 |
PRK05580 |
primosome assembly protein PriA; Validated |
303-361 |
6.72e-04 |
|
primosome assembly protein PriA; Validated
Pssm-ID: 235514 [Multi-domain] Cd Length: 679 Bit Score: 42.07 E-value: 6.72e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18424420 303 LNKFKAGECNILVCTDVASRGLDIPSVD--VVINYDIPTNSKDY---------IHRV-GRTARAGRSGVGI 361
Cdd:PRK05580 473 LAQFARGEADILIGTQMLAKGHDFPNVTlvGVLDADLGLFSPDFrasertfqlLTQVaGRAGRAEKPGEVL 543
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
36-350 |
8.57e-04 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 41.80 E-value: 8.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 36 QAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALLEYvydsePKKGRRPDPAFfaCV-LSPTRELA--IQ-------- 104
Cdd:PRK13767 37 QRYAIPLIHEGKNVLISSPTGSGKTLAAFLAIIDELFRL-----GREGELEDKVY--CLyVSPLRALNndIHrnleeplt 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 105 -IAEQFEALGADIS-LRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDHMSDTKgFS--LKSLKYLVLDEADRL---- 176
Cdd:PRK13767 110 eIREIAKERGEELPeIRVAIRTGDTSSYEKQKMLKKPPHILITTPESLAILLNSPK-FRekLRTVKWVIVDEIHSLaenk 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 177 -----------LNEDFEKSLNQI--------LEEI----------PLERKTFLFSATMTKKVrKLQRAClrnPVK--IEA 225
Cdd:PRK13767 189 rgvhlslslerLEELAGGEFVRIglsatiepLEEVakflvgyeddGEPRDCEIVDARFVKPF-DIKVIS---PVDdlIHT 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 226 ASK------YSTVDTLKQQYRfvaakykdcylvyilsempesTSMIFTRTCDGTRFLALVLRSLGFRAIPIS------GQ 293
Cdd:PRK13767 265 PAEeisealYETLHELIKEHR---------------------TTLIFTNTRSGAERVLYNLRKRFPEEYDEDnigahhSS 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 18424420 294 MTQSKRLGALNKFKAGECNILVCTDVASRGLDIPSVDVVINYDIPTNSKDYIHRVGR 350
Cdd:PRK13767 324 LSREVRLEVEEKLKRGELKVVVSSTSLELGIDIGYIDLVVLLGSPKSVSRLLQRIGR 380
|
|
| SF2_C_priA |
cd18804 |
C-terminal helicase domain of ATP-dependent helicase PriA; PriA, also known as replication ... |
303-358 |
8.93e-04 |
|
C-terminal helicase domain of ATP-dependent helicase PriA; PriA, also known as replication factor Y or primosomal protein N', is a 3'-->5' DNA helicase that acts to remodel stalled replication forks and as a specificity factor for origin-independent assembly of a new replisome at the stalled fork. PriA is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350191 [Multi-domain] Cd Length: 238 Bit Score: 40.69 E-value: 8.93e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18424420 303 LNKFKAGECNILVCTDVASRGLDIPSVD--VVINYDIPTNSKDY---------IHRV-GRTARAGRSG 358
Cdd:cd18804 137 LDQFERGEIDILIGTQMIAKGLDFPNVTlvGILNADSGLNSPDFraserafqlLTQVsGRAGRGDKPG 204
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
36-358 |
1.16e-03 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 41.24 E-value: 1.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 36 QAEALPFALEGKDVIGLAQTGSGKTGAFAIPILqalleyVYDSepkkgrrpdpafFACVLSPTRELAIQIAEQFEALGAD 115
Cdd:PRK11057 30 QQEIIDAVLSGRDCLVVMPTGGGKSLCYQIPAL------VLDG------------LTLVVSPLISLMKDQVDQLLANGVA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 116 islrCAVLVGGIDRMQQ-TIALGKRP---HVIVATPGRLW-----DHMSDTKgfslksLKYLVLDEADRL--LNEDFE-- 182
Cdd:PRK11057 92 ----AACLNSTQTREQQlEVMAGCRTgqiKLLYIAPERLMmdnflEHLAHWN------PALLAVDEAHCIsqWGHDFRpe 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 183 -KSLNQILEEIPlERKTFLFSATMTKKVRK--LQRACLRNPVkIEAAS------KYSTVDTLK---QQYRFVAAKYKDCY 250
Cdd:PRK11057 162 yAALGQLRQRFP-TLPFMALTATADDTTRQdiVRLLGLNDPL-IQISSfdrpniRYTLVEKFKpldQLMRYVQEQRGKSG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 251 LVYILSEmpESTSMIFTRtcdgtrflalvLRSLGFRAIPISGQMTQSKRLGALNKFKAGECNILVCTDVASRGLDIPSVD 330
Cdd:PRK11057 240 IIYCNSR--AKVEDTAAR-----------LQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVR 306
|
330 340
....*....|....*....|....*...
gi 18424420 331 VVINYDIPTNSKDYIHrvgRTARAGRSG 358
Cdd:PRK11057 307 FVVHFDIPRNIESYYQ---ETGRAGRDG 331
|
|
| DEXHc_ASCC3_1 |
cd18020 |
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
53-180 |
1.29e-03 |
|
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350778 [Multi-domain] Cd Length: 199 Bit Score: 40.11 E-value: 1.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 53 AQTGSGKTGAFAIPILQALLEYVYDsepkKGRRPDPAFFACVLSPTRELAIQIAEQFEALGADISLRCAVLVGGidrMQQ 132
Cdd:cd18020 24 APTGAGKTNIAMLTILHEIRQHVNQ----GGVIKKDDFKIVYIAPMKALAAEMVEKFSKRLAPLGIKVKELTGD---MQL 96
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 18424420 133 TIALGKRPHVIVATPGRlWDHMS--DTKGFSLKSL-KYLVLDEAdRLLNED 180
Cdd:cd18020 97 TKKEIAETQIIVTTPEK-WDVVTrkSSGDVALSQLvRLLIIDEV-HLLHDD 145
|
|
| mfd |
TIGR00580 |
transcription-repair coupling factor (mfd); All proteins in this family for which functions ... |
292-333 |
1.80e-03 |
|
transcription-repair coupling factor (mfd); All proteins in this family for which functions are known are DNA-dependent ATPases that function in the process of transcription-coupled DNA repair in which the repair of the transcribed strand of actively transcribed genes is repaired at a higher rate than the repair of non-transcribed regions of the genome and than the non-transcribed strand of the same gene. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). This family is closely related to the RecG and UvrB families. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273152 [Multi-domain] Cd Length: 926 Bit Score: 40.80 E-value: 1.80e-03
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 18424420 292 GQMTQSKRLGALNKFKAGECNILVCTDVASRGLDIPSVDVVI 333
Cdd:TIGR00580 694 GQMTENELEEVMLEFYKGEFQVLVCTTIIETGIDIPNANTII 735
|
|
| DEXHc_Hef |
cd18035 |
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs ... |
43-175 |
2.54e-03 |
|
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. All archaea encode a protein of the XPF/MUS81/FANCM family of endonucleases. It exists in two forms: a long form, referred as Hef which consists of an N-terminal helicase fused to a C-terminal nuclease and is specific to euryarchaea and a short form, referred as XPF which lacks the helicase domain and is specific to crenarchaea and thaumarchaea. Hef has the unique feature of having both active helicase and nuclease domains. This domain configuration is highly similar with the human FANCM, a possible ortholog of archaeal Hef proteins. Hef is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350793 [Multi-domain] Cd Length: 181 Bit Score: 38.65 E-value: 2.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424420 43 ALEGKDVIgLAQTGSGKTgAFAIPILQALLEyvydsepKKGRRpdpaffACVLSPTRELAIQIAEQFEALgADISLRCAV 122
Cdd:cd18035 14 ALNGNTLI-VLPTGLGKT-IIAILVAADRLT-------KKGGK------VLILAPSRPLVEQHAENLKRV-LNIPDKITS 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 18424420 123 LVGGIDRMQQTiALGKRPHVIVATPGRLWDHMSDTKgFSLKSLKYLVLDEADR 175
Cdd:cd18035 78 LTGEVKPEERA-ERWDASKIIVATPQVIENDLLAGR-ITLDDVSLLIFDEAHH 128
|
|
| |
